| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 12 | Bo Naylor | 21 | C | L | 87 | 87 | 313 | 41 | 59 | 13 | 1 | 10 | 44 | 10 | 0 | 37 | 112 | 3 | 1 | 1 | 1 | 3 | 104 | 355 | 24 | 35 | .188 | .280 | .332 | .612 | .294 | .144 | .255 | 10.42 | 31.55 | 3.03 | 31.30 | 2018- 1- 29-CLE | premium | premium | premium | MLB | 2022-2026 | 2018-2026 | 2021 |
| 1 | Jose Fermin | 22 | 3B-2B | R | 97 | 84 | 295 | 40 | 76 | 15 | 2 | 6 | 39 | 4 | 4 | 23 | 38 | 10 | 4 | 3 | 0 | 8 | 113 | 335 | 23 | 53 | .258 | .329 | .383 | .712 | .203 | .125 | .276 | 6.87 | 11.34 | 1.65 | 49.17 | 2015- UDFA -CLE | premium | premium | premium | MLB | 2023-2026 | 2016-2026 | 2021 |
| 6 | Andruw Monasterio | 24 | 3B-2B | R | 110 | 74 | 265 | 49 | 77 | 14 | 4 | 7 | 51 | 6 | 4 | 30 | 76 | 4 | 0 | 5 | 0 | 3 | 120 | 304 | 25 | 52 | .291 | .365 | .453 | .818 | .283 | .162 | .374 | 9.87 | 25.00 | 2.53 | 37.86 | 2014- UDFA -CHN | premium | premium | premium | MLB | 2023-2026 | 2015-2026 | 2021 |
| 29 | Will Benson | 23 | RF-CF | L | 116 | 80 | 262 | 63 | 58 | 13 | 5 | 14 | 42 | 14 | 3 | 60 | 104 | 5 | 1 | 2 | 1 | 0 | 123 | 330 | 32 | 26 | .221 | .374 | .469 | .843 | .519 | .248 | .301 | 18.18 | 31.52 | 1.73 | 18.71 | 2016- 1- 14-CLE | premium | premium | premium | MLB | 2022-2026 | 2016-2026 | 2021 |
| 2 | Chris Roller | 24 | LF-CF | R | 79 | 70 | 246 | 25 | 50 | 12 | 2 | 1 | 27 | 14 | 4 | 23 | 72 | 5 | 1 | 4 | 2 | 2 | 69 | 279 | 15 | 35 | .203 | .281 | .280 | .561 | .211 | .077 | .277 | 8.24 | 25.81 | 3.13 | 246.00 | 2017- 30- 910-LAN | premium | premium | premium | MLB | 2024-2024 | 2016-2025 | 2021 |
| 9 | Richie Palacios | 24 | 2B | L | 120 | 66 | 244 | 53 | 73 | 24 | 3 | 6 | 36 | 10 | 3 | 33 | 42 | 4 | 0 | 2 | 0 | 5 | 121 | 283 | 33 | 40 | .299 | .389 | .496 | .885 | .361 | .197 | .338 | 11.66 | 14.84 | 1.27 | 40.67 | 2018- 3- 103-CLE | premium | premium | premium | MLB | 2022-2026 | 2016-2026 | 2021 |
| 17 | Marcos Gonzalez | 21 | 1B-3B | R | 91 | 61 | 205 | 26 | 46 | 11 | 0 | 7 | 19 | 0 | 2 | 17 | 75 | 2 | 0 | 1 | 0 | 0 | 78 | 225 | 18 | 28 | .224 | .289 | .380 | .669 | .229 | .156 | .315 | 7.56 | 33.33 | 4.41 | 29.29 | 2016- UDFA -CLE | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 13 | Jonathan Engelmann | 24 | 1B | R | 95 | 58 | 198 | 30 | 44 | 9 | 1 | 7 | 23 | 1 | 2 | 22 | 66 | 4 | 0 | 1 | 0 | 3 | 76 | 225 | 17 | 27 | .222 | .311 | .384 | .695 | .268 | .162 | .294 | 9.78 | 29.33 | 3.00 | 28.29 | 2018- 31- 943-CLE | premium | premium | premium | AAA | 2016-2022 | 2021 | |
| 4 | Steven Kwan | 23 | CF-LF | L | 127 | 51 | 193 | 42 | 65 | 12 | 3 | 7 | 31 | 4 | 2 | 22 | 23 | 3 | 2 | 1 | 0 | 2 | 104 | 221 | 22 | 43 | .337 | .411 | .539 | .950 | .326 | .202 | .354 | 9.95 | 10.41 | 1.05 | 27.57 | 2018- 5- 163-CLE | premium | premium | premium | MLB | 2022-2026 | 2016-2026 | 2021 |
| 39 | Oscar Gonzalez | 23 | RF-LF | R | 129 | 49 | 188 | 31 | 62 | 12 | 0 | 13 | 41 | 1 | 0 | 11 | 36 | 0 | 0 | 0 | 1 | 2 | 113 | 199 | 25 | 37 | .330 | .367 | .601 | .968 | .335 | .271 | .353 | 5.53 | 18.09 | 3.27 | 14.46 | 2014- UDFA -CLE | premium | premium | premium | MLB | 2022-2025 | 2015-2025 | 2021 |
| 9 | Brayan Rocchio | 20 | SS | B | 116 | 44 | 184 | 34 | 54 | 13 | 4 | 6 | 30 | 7 | 4 | 13 | 41 | 6 | 0 | 0 | 0 | 2 | 93 | 203 | 23 | 31 | .293 | .360 | .505 | .865 | .299 | .212 | .350 | 6.40 | 20.20 | 3.15 | 30.67 | 2017- UDFA -CLE | premium | premium | premium | MLB | 2023-2026 | 2018-2026 | 2021 |
| 68 | Tyler Freeman | 22 | SS | R | 114 | 41 | 164 | 26 | 53 | 14 | 2 | 2 | 19 | 4 | 2 | 8 | 21 | 6 | 0 | 2 | 0 | 1 | 77 | 180 | 18 | 35 | .323 | .372 | .470 | .842 | .207 | .147 | .357 | 4.44 | 11.67 | 2.63 | 82.00 | 2017- 2- 71-CLE | premium | premium | premium | MLB | 2022-2026 | 2017-2026 | 2021 |
| 8 | Alex Call | 26 | CF | R | 122 | 43 | 155 | 34 | 48 | 13 | 1 | 5 | 23 | 12 | 2 | 21 | 26 | 1 | 0 | 3 | 0 | 2 | 78 | 180 | 19 | 29 | .310 | .389 | .503 | .892 | .394 | .193 | .339 | 11.67 | 14.44 | 1.24 | 31.00 | 2016- 3- 86-CHA | premium | premium | premium | MLB | 2022-2026 | 2014-2026 | 2021 |
| 7 | Will Brennan | 23 | CF-LF | L | 101 | 40 | 150 | 28 | 42 | 6 | 0 | 2 | 20 | 2 | 2 | 18 | 29 | 5 | 1 | 3 | 0 | 0 | 54 | 177 | 8 | 34 | .280 | .369 | .360 | .729 | .200 | .080 | .328 | 10.17 | 16.38 | 1.61 | 75.00 | 2019- 8- 250-CLE | premium | premium | premium | MLB | 2022-2026 | 2017-2026 | 2021 |
| 22 | Ike Freeman | 23 | 2B-1B | R | 75 | 41 | 122 | 19 | 23 | 4 | 0 | 1 | 10 | 0 | 1 | 13 | 43 | 2 | 3 | 0 | 0 | 4 | 30 | 140 | 5 | 18 | .189 | .277 | .246 | .523 | .156 | .057 | .282 | 9.29 | 30.71 | 3.31 | 122.00 | 2019- 14- 430-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | |
| 10 | Bryan Lavastida | 22 | C | R | 112* | 29 | 103 | 16 | 30 | 7 | 1 | 3 | 17 | 2 | 3 | 12 | 28 | 2 | 1 | 1 | 0 | 2 | 48 | 119 | 11 | 19 | .291 | .373 | .466 | .839 | .282 | .175 | .370 | 10.08 | 23.53 | 2.33 | 34.33 | 2018- 15- 463-CLE | premium | premium | premium | MLB | 2022-2022 | 2018-2026 | 2021 |
| 10 | Mike Rivera | 25 | C | R | 78* | 26 | 86 | 11 | 14 | 3 | 0 | 3 | 15 | 0 | 0 | 10 | 25 | 2 | 0 | 3 | 0 | 2 | 26 | 101 | 6 | 8 | .163 | .257 | .302 | .559 | .256 | .139 | .180 | 9.90 | 24.75 | 2.50 | 28.67 | 2017- 6- 192-CLE | premium | premium | premium | AAA | 2015-2022 | 2021 | |
| 29 | George Valera | 20 | RF-LF | L | 102* | 23 | 86 | 6 | 23 | 3 | 0 | 3 | 22 | 1 | 0 | 11 | 30 | 0 | 0 | 3 | 0 | 1 | 35 | 100 | 6 | 17 | .267 | .340 | .407 | .747 | .279 | .140 | .357 | 11.00 | 30.00 | 2.73 | 28.67 | 2017- UDFA -CLE | premium | premium | premium | MLB | 2025-2026 | 2018-2026 | 2021 |
| 75 | Daniel Schneemann | 24 | SS | L | 106* | 25 | 82 | 7 | 22 | 3 | 0 | 3 | 17 | 3 | 1 | 9 | 20 | 1 | 0 | 0 | 0 | 0 | 34 | 92 | 6 | 16 | .268 | .348 | .415 | .763 | .280 | .147 | .322 | 9.78 | 21.74 | 2.22 | 27.33 | 2018- 33-1003-CLE | premium | premium | premium | MLB | 2024-2026 | 2016-2026 | 2021 |
| 39 | Clark Scolamiero | 25 | RF-LF | L | 73* | 27 | 81 | 9 | 11 | 4 | 0 | 2 | 6 | 4 | 1 | 8 | 41 | 3 | 1 | 0 | 0 | 1 | 21 | 93 | 6 | 5 | .136 | .239 | .259 | .498 | .259 | .123 | .237 | 8.60 | 44.09 | 5.13 | 40.50 | 2017- 22- 672-CLE | premium | premium | premium | AA | 2015-2021 | 2021 | |
| 10 | Josh Rolette | 25 | 1B | L | 64* | 24 | 80 | 7 | 13 | 4 | 0 | 1 | 10 | 0 | 1 | 6 | 31 | 0 | 1 | 1 | 0 | 1 | 20 | 88 | 5 | 8 | .163 | .218 | .250 | .468 | .150 | .087 | .245 | 6.82 | 35.23 | 5.17 | 80.00 | 2017- 39-1182-CLE | premium | premium | premium | AA | 2016-2022 | 2021 | |
| 6 | Victor Nova | 21 | 3B | L | 85* | 23 | 79 | 10 | 19 | 3 | 0 | 0 | 5 | 0 | 1 | 10 | 25 | 0 | 1 | 0 | 0 | 0 | 22 | 90 | 3 | 16 | .241 | .326 | .278 | .604 | .152 | .037 | .352 | 11.11 | 27.78 | 2.50 | 0.00 | 2017- UDFA -SDN | premium | premium | premium | AAA | 2018-2024 | 2021 | |
| 13 | Trenton Brooks | 25 | 1B | L | 127* | 23 | 71 | 14 | 19 | 3 | 1 | 4 | 19 | 1 | 0 | 20 | 18 | 3 | 0 | 2 | 1 | 2 | 36 | 96 | 8 | 11 | .268 | .438 | .507 | .945 | .535 | .239 | .294 | 20.83 | 18.75 | 0.90 | 17.75 | 2016- 17- 512-CLE | premium | premium | premium | MLB | 2024-2025 | 2014-2025 | 2021 |
| 22 | Angel Lopez | 24 | C | R | 6 | 18 | 1 | 4 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 5 | 1 | 0 | 0 | 0 | 1 | 5 | 20 | 1 | 3 | .222 | .300 | .278 | .578 | .111 | .056 | .308 | 5.00 | 25.00 | 5.00 | 0.00 | 2017- 13- 402-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | ||
| - | Roberto Perez | 32 | C | R | 6 | 14 | 1 | 5 | 2 | 0 | 0 | 3 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 2 | 7 | 15 | 2 | 3 | .357 | .400 | .500 | .900 | .214 | .143 | .455 | 6.67 | 20.00 | 3.00 | 0.00 | 2008- 33-1011-CLE | premium | premium | premium | MLB | 2014-2023 | 2009-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| - | Austen Wade | 25 | RF | L | 4 | 13 | 1 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 13 | 1 | 1 | .154 | .154 | .231 | .385 | .000 | .077 | .250 | 0.00 | 38.46 | 0.00 | 0.00 | 2017- 5- 162-CLE | premium | premium | premium | AA | 2015-2021 | 2021 | ||
| 8 | Eric Rodriguez | 22 | C | R | 5 | 11 | 2 | 2 | 0 | 0 | 1 | 3 | 0 | 0 | 1 | 5 | 1 | 0 | 0 | 0 | 0 | 5 | 13 | 1 | 1 | .182 | .308 | .455 | .763 | .364 | .273 | .200 | 7.69 | 38.46 | 5.00 | 11.00 | 2018- 21- 643-CLE | premium | premium | premium | AAA | 2018-2023 | 2021 | ||
| - | Franmil Reyes | 25 | DH | R | 3 | 7 | 2 | 3 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 9 | 7 | 2 | 1 | .429 | .429 | 1.286 | 1.715 | .857 | .857 | .500 | 0.00 | 42.86 | 0.00 | 3.50 | 2011- UDFA -SDN | premium | premium | premium | MLB | 2018-2023 | 2012-2025 | 2021 | |
| - | Ernie Clement | 25 | SS | R | 2 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 1 | 0 | .143 | .143 | .286 | .429 | .143 | .143 | .250 | 0.00 | 42.86 | 0.00 | 0.00 | 2017- 4- 132-CLE | premium | premium | premium | MLB | 2021-2026 | 2015-2026 | 2021 | |
| Totals: | 1115 | 3922 | 628 | 998 | 220 | 30 | 116 | 577 | 100 | 43 | 440 | 1046 | 73 | 17 | 38 | 6 | 49 | 1626 | 4490 | 366 | 632 | .254 | .338 | .415 | .752 | .287 | .160 | .315 | 9.80 | 23.30 | 2.38 | 33.81 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 11 | Juan Hillman | 24 | L | 10 | 4 | 3.77 | 21 | 20 | 1 | 1 | 1 | 0 | 0 | 107.1 | 110 | 49 | 45 | 16 | 32 | 85 | 6 | 0 | 12 | 1.32 | 9.22 | 1.34 | 2.68 | 7.13 | 4.11 | 2.66 | 2015- 2- 59-CLE | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 32 | Thomas Ponticelli | 24 | R | 7 | 5 | 3.09 | 27 | 12 | 0 | 0 | 15 | 6 | 0 | 87.1 | 73 | 38 | 30 | 8 | 33 | 77 | 7 | 0 | 7 | 1.21 | 7.52 | 0.82 | 3.40 | 7.94 | 3.92 | 2.33 | 2018- 12- 373-CLE | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 30 | Tanner Tully | 26 | L | 6 | 3 | 2.68 | 17 | 12 | 0 | 0 | 5 | 1 | 1 | 74.0 | 81 | 26 | 22 | 6 | 18 | 64 | 4 | 0 | 5 | 1.34 | 9.85 | 0.73 | 2.19 | 7.78 | 3.16 | 3.56 | 2016- 26- 782-CLE | premium | premium | premium | MLB | 2022-2022 | 2014-2025 | 2021 |
| 15 | Logan Allen | 22 | L | 4 | 0 | 2.85 | 12 | 10 | 0 | 0 | 2 | 1 | 0 | 60.0 | 40 | 20 | 19 | 9 | 13 | 76 | 2 | 0 | 3 | 0.88 | 6.00 | 1.35 | 1.95 | 11.40 | 3.00 | 5.85 | 2020- 2- 56-CLE | premium | premium | premium | MLB | 2023-2026 | 2018-2026 | 2021 |
| 36 | Dakody Clemmer | 25 | R | 3 | 2 | 3.40 | 35 | 0 | 0 | 0 | 35 | 8 | 0 | 50.1 | 32 | 28 | 19 | 2 | 33 | 62 | 3 | 1 | 11 | 1.29 | 5.72 | 0.36 | 5.90 | 11.09 | 5.01 | 1.88 | 2016- 19- 572-CLE | premium | premium | premium | AA | 2015-2022 | 2021 | |
| 27 | Adam Scott | 25 | L | 3 | 2 | 3.49 | 11 | 11 | 0 | 0 | 0 | 0 | 0 | 49.0 | 39 | 21 | 19 | 5 | 18 | 60 | 2 | 0 | 3 | 1.16 | 7.16 | 0.92 | 3.31 | 11.02 | 3.86 | 3.33 | 2018- 4- 133-CLE | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 38 | Jake Miednik | 25 | L | 2 | 0 | 3.12 | 32 | 0 | 0 | 0 | 32 | 7 | 1 | 43.1 | 39 | 20 | 15 | 6 | 20 | 55 | 0 | 0 | 2 | 1.36 | 8.10 | 1.25 | 4.15 | 11.42 | 4.15 | 2.75 | 2018- 20- 613-CLE | premium | premium | premium | AA | 2017-2025 | 2021 | |
| 26 | Aaron Pinto | 24 | R | 3 | 1 | 2.30 | 25 | 0 | 0 | 0 | 25 | 10 | 5 | 43.0 | 31 | 11 | 11 | 5 | 13 | 67 | 3 | 0 | 1 | 1.02 | 6.49 | 1.05 | 2.72 | 14.02 | 2.30 | 5.15 | 2018- 24- 733-CLE | premium | premium | premium | AAA | 2015-2022 | 2021 | |
| 34 | Skylar Arias | 24 | L | 7 | 2 | 6.92 | 36 | 0 | 0 | 0 | 36 | 5 | 0 | 40.1 | 35 | 33 | 31 | 2 | 35 | 53 | 7 | 0 | 12 | 1.74 | 7.81 | 0.45 | 7.81 | 11.83 | 7.36 | 1.51 | 2016- 24- 722-CLE | premium | premium | premium | AA | 2016-2025 | 2021 | |
| 27 | Alex Royalty | 24 | R | 1 | 2 | 4.95 | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 40.0 | 39 | 26 | 22 | 4 | 14 | 37 | 4 | 0 | 1 | 1.33 | 8.78 | 0.90 | 3.15 | 8.33 | 5.85 | 2.64 | 2018- 8- 253-CLE | premium | premium | premium | AA | 2016-2022 | 2021 | |
| 46 | Nic Enright | 24 | R | 3 | 4 | 4.31 | 23 | 0 | 0 | 0 | 23 | 12 | 2 | 39.2 | 28 | 21 | 19 | 5 | 10 | 56 | 4 | 0 | 1 | 0.96 | 6.35 | 1.13 | 2.27 | 12.71 | 4.76 | 5.60 | 2019- 20- 610-CLE | premium | premium | premium | MLB | 2025-2025 | 2016-2025 | 2021 |
| 45 | Nick Mikolajchak | 23 | R | 2 | 5 | 3.18 | 30 | 0 | 0 | 0 | 30 | 23 | 8 | 39.2 | 34 | 17 | 14 | 7 | 9 | 57 | 1 | 0 | 0 | 1.08 | 7.71 | 1.59 | 2.04 | 12.93 | 3.86 | 6.33 | 2019- 11- 340-CLE | premium | premium | premium | AAA | 2017-2026 | 2021 | |
| 48 | Konnor Pilkington | 23 | L | 3 | 2 | 2.33 | 8 | 7 | 0 | 0 | 1 | 0 | 0 | 38.2 | 25 | 11 | 10 | 2 | 18 | 49 | 2 | 0 | 2 | 1.11 | 5.82 | 0.47 | 4.19 | 11.41 | 2.56 | 2.72 | 2018- 3- 81-CHA | premium | premium | premium | MLB | 2022-2025 | 2016-2026 | 2021 |
| 44 | Manuel Alvarez | 25 | R | 1 | 0 | 5.70 | 28 | 0 | 0 | 0 | 28 | 10 | 3 | 36.1 | 32 | 23 | 23 | 4 | 30 | 51 | 11 | 1 | 2 | 1.71 | 7.93 | 0.99 | 7.43 | 12.63 | 5.70 | 1.70 | 2017- UDFA -CLE | premium | premium | premium | AAA | 2018-2025 | 2021 | |
| 47 | Peyton Battenfield | 23 | R | 2 | 1 | 3.28 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 35.2 | 24 | 13 | 13 | 4 | 7 | 36 | 0 | 0 | 2 | 0.87 | 6.06 | 1.01 | 1.77 | 9.08 | 3.28 | 5.14 | 2019- 9- 286-HOU | premium | premium | premium | MLB | 2023-2023 | 2017-2024 | 2021 |
| 48 | Juan Mota | 25 | R | 2 | 1 | 4.20 | 23 | 0 | 0 | 0 | 23 | 14 | 5 | 30.0 | 26 | 18 | 14 | 2 | 18 | 49 | 5 | 0 | 2 | 1.47 | 7.80 | 0.60 | 5.40 | 14.70 | 5.40 | 2.72 | 2015- UDFA -CLE | premium | premium | premium | AAA | 2016-2021 | 2021 | |
| 41 | Ben Krauth | 27 | L | 3 | 2 | 4.66 | 20 | 0 | 0 | 0 | 20 | 5 | 2 | 29.0 | 23 | 17 | 15 | 5 | 13 | 37 | 0 | 0 | 2 | 1.24 | 7.14 | 1.55 | 4.03 | 11.48 | 5.28 | 2.85 | 2016- 16- 482-CLE | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 41 | Shane McCarthy | 24 | R | 0 | 2 | 5.02 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 28.2 | 22 | 18 | 16 | 4 | 13 | 28 | 1 | 0 | 0 | 1.22 | 6.91 | 1.26 | 4.08 | 8.79 | 5.65 | 2.15 | 2018- 18- 553-CLE | premium | premium | premium | AA | 2015-2023 | 2021 | |
| 46 | Francisco Perez | 23 | L | 3 | 0 | 0.67 | 11 | 0 | 0 | 0 | 11 | 4 | 2 | 27.0 | 8 | 2 | 2 | 0 | 9 | 46 | 0 | 0 | 0 | 0.63 | 2.67 | 0.00 | 3.00 | 15.33 | 0.67 | 5.11 | 2014- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2015-2024 | 2021 |
| 33 | Zach Draper | 26 | L | 0 | 2 | 6.43 | 7 | 3 | 0 | 0 | 4 | 0 | 0 | 21.0 | 25 | 18 | 15 | 5 | 7 | 18 | 0 | 0 | 0 | 1.52 | 10.71 | 2.14 | 3.00 | 7.71 | 7.71 | 2.57 | 2017- 30- 912-CLE | premium | premium | premium | AAA | 2014-2022 | 2021 | |
| 47 | Cody Morris | 24 | R | 0 | 0 | 1.35 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 20.0 | 14 | 3 | 3 | 1 | 7 | 29 | 2 | 0 | 2 | 1.05 | 6.30 | 0.45 | 3.15 | 13.05 | 1.35 | 4.14 | 2018- 7- 223-CLE | premium | premium | premium | MLB | 2022-2023 | 2017-2024 | 2021 |
| 75 | Eli Lingos | 25 | L | 3 | 1 | 4.95 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 20.0 | 22 | 11 | 11 | 0 | 9 | 16 | 1 | 0 | 1 | 1.55 | 9.90 | 0.00 | 4.05 | 7.20 | 4.95 | 1.78 | 2018- 22- 673-CLE | premium | premium | premium | AAA | 2015-2023 | 2021 | |
| 37 | Kyle Marman | 24 | R | 4 | 0 | 5.85 | 20 | 0 | 0 | 0 | 20 | 9 | 1 | 20.0 | 20 | 15 | 13 | 4 | 13 | 20 | 4 | 0 | 0 | 1.65 | 9.00 | 1.80 | 5.85 | 9.00 | 6.75 | 1.54 | 2018- 13- 403-CLE | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 47 | Eric Mock | 24 | R | 0 | 1 | 4.67 | 5 | 3 | 0 | 0 | 2 | 0 | 0 | 17.1 | 17 | 10 | 9 | 4 | 7 | 20 | 2 | 0 | 1 | 1.38 | 8.83 | 2.08 | 3.63 | 10.38 | 5.19 | 2.86 | 2019- 25- 760-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | |
| 30 | Joey Cantillo | 21 | L | 0 | 2 | 4.50 | 5 | 1 | 0 | 0 | 4 | 0 | 0 | 8.0 | 8 | 4 | 4 | 0 | 10 | 12 | 0 | 0 | 0 | 2.25 | 9.00 | 0.00 | 11.25 | 13.50 | 4.50 | 1.20 | 2017- 16- 468-SDN | premium | premium | premium | MLB | 2024-2026 | 2017-2026 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| - | Aaron Civale | 26 | R | 1 | 0 | 1.29 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 7.0 | 4 | 2 | 1 | 0 | 3 | 8 | 0 | 0 | 0 | 1.00 | 5.14 | 0.00 | 3.86 | 10.29 | 2.57 | 2.67 | 2016- 3- 92-CLE | premium | premium | premium | MLB | 2019-2026 | 2014-2026 | 2021 |
| 15 | Zach Plesac | 26 | R | 0 | 1 | 5.79 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4.2 | 5 | 4 | 3 | 1 | 2 | 6 | 0 | 0 | 0 | 1.50 | 9.64 | 1.93 | 3.86 | 11.57 | 7.71 | 3.00 | 2016- 12- 362-CLE | premium | premium | premium | MLB | 2019-2024 | 2014-2025 | 2021 |
| 11 | Xzavion Curry | 22 | R | 0 | 0 | 3.86 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.2 | 6 | 2 | 2 | 2 | 0 | 5 | 0 | 0 | 0 | 1.29 | 11.57 | 3.86 | 0.00 | 9.64 | 3.86 | 0.00 | 2019- 7- 220-CLE | premium | premium | premium | MLB | 2022-2025 | 2017-2026 | 2021 |
| - | Shane Bieber | 26 | R | 0 | 0 | 8.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3.1 | 3 | 3 | 3 | 2 | 1 | 4 | 0 | 0 | 0 | 1.20 | 8.10 | 5.40 | 2.70 | 10.80 | 8.10 | 4.00 | 2016- 4- 122-CLE | premium | premium | premium | MLB | 2018-2025 | 2014-2026 | 2021 |
| 30 | Alec Wisely | 23 | R | 0 | 1 | 23.14 | 3 | 0 | 0 | 0 | 3 | 2 | 1 | 2.1 | 6 | 6 | 6 | 1 | 2 | 4 | 1 | 0 | 0 | 3.43 | 23.14 | 3.86 | 7.71 | 15.43 | 23.14 | 2.00 | 2019- 34-1030-CLE | premium | premium | premium | AA | 2016-2021 | 2021 | |
| - | Andrew Misiaszek | 23 | L | 0 | 0 | 27.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.1 | 5 | 4 | 4 | 0 | 1 | 1 | 1 | 0 | 0 | 4.50 | 33.75 | 0.00 | 6.75 | 6.75 | 27.00 | 1.00 | 2019- 32- 970-CLE | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 32 | Justin Garza | 27 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 2.00 | 0.00 | 0.00 | 18.00 | 9.00 | 0.00 | 0.50 | 2015- 8- 244-CLE | premium | premium | premium | MLB | 2021-2025 | 2013-2025 | 2021 |
| 39 | Clark Scolamiero | 25 | L | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 9.00 | 0.00 | 0.00 | 2017- 22- 672-CLE | premium | premium | premium | AA | 2015-2021 | 2021 | |
| Totals: | 73 | 46 | 3.78 | 442 | 119 | 1 | 1 | 118 | 323 | 31 | 1031.0 | 876 | 494 | 433 | 116 | 420 | 1190 | 73 | 2 | 72 | 1.26 | 7.65 | 1.01 | 3.67 | 10.39 | 4.31 | 2.83 | premium | premium | premium |