| 2022-04-05 | April | Toledo Mud Hens | Vis | L | 0-5 | boxscore | 10,522 | 2:35 | 0-1 | Fifth Third Field | Toledo,Ohio |
| 2022-04-06 | April | Toledo Mud Hens | Vis | W | 6-3 | boxscore | 2,103 | 3:05 | 1-1 | Fifth Third Field | Toledo,Ohio |
| 2022-04-07 | April | Toledo Mud Hens | Vis | W | 8-5 | boxscore | 2,146 | 3:48 | 2-1 | Fifth Third Field | Toledo,Ohio |
| 2022-04-08 | April | Toledo Mud Hens | Vis | W | 7-4 | boxscore | 2,756 | 3:26 | 3-1 | Fifth Third Field | Toledo,Ohio |
| 2022-04-09 | April | Toledo Mud Hens | Vis | W | 9-0 | boxscore | 3,387 | 2:44 | 4-1 | Fifth Third Field | Toledo,Ohio |
| 2022-04-10 | April | Toledo Mud Hens | Vis | L | 1-2 | boxscore | 3,750 | 2:36 | 4-2 | Fifth Third Field | Toledo,Ohio |
| 2022-04-12 | April | Buffalo Bisons | Home | L | 4-6 | boxscore | 8,170 | 3:17 | 4-3 | Frontier Field | Rochester,New York |
| 2022-04-14 | April | Buffalo Bisons | Home | L | 1-10 | boxscore | 2,902 | 3:10 | 4-4 | Frontier Field | Rochester,New York |
| 2022-04-15 | April | Buffalo Bisons | Home | W | 3-2 | boxscore | 0 | 1:53 | 5-4 | Frontier Field | Rochester,New York |
| 2022-04-15 | April | Buffalo Bisons | Home | L | 4-9 | boxscore | 3,709 | 2:27 | 5-5 | Frontier Field | Rochester,New York |
| 2022-04-16 | April | Buffalo Bisons | Home | W | 11-10 | boxscore | 2,920 | 3:34 | 6-5 | Frontier Field | Rochester,New York |
| 2022-04-17 | April | Buffalo Bisons | Home | W | 8-1 | boxscore | 2,462 | 2:17 | 7-5 | Frontier Field | Rochester,New York |
| 2022-04-19 | April | Lehigh Valley IronPigs | Vis | L | 1-6 | boxscore | 4,354 | 2:32 | 7-6 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-20 | April | Lehigh Valley IronPigs | Vis | L | 4-12 | boxscore | 4,798 | 2:48 | 7-7 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-21 | April | Lehigh Valley IronPigs | Vis | W | 6-5 | boxscore | 5,015 | 2:57 | 8-7 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-22 | April | Lehigh Valley IronPigs | Vis | W | 4-3 | boxscore | 8,181 | 2:51 | 9-7 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-23 | April | Lehigh Valley IronPigs | Vis | L | 8-10 | boxscore | 6,889 | 2:55 | 9-8 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-24 | April | Lehigh Valley IronPigs | Vis | L | 1-10 | boxscore | 7,501 | 3:01 | 9-9 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-04-26 | April | Syracuse Mets | Home | W | 10-9 | boxscore | 2,664 | 2:43 | 10-9 | Frontier Field | Rochester,New York |
| 2022-04-28 | April | Syracuse Mets | Home | W | 13-6 | boxscore | 2,586 | 3:00 | 11-9 | Frontier Field | Rochester,New York |
| 2022-04-29 | April | Syracuse Mets | Home | L | 4-6 | boxscore | 3,595 | 2:30 | 11-10 | Frontier Field | Rochester,New York |
| 2022-04-30 | April | Syracuse Mets | Home | W | 3-0 | boxscore | 0 | 1:42 | 12-10 | Frontier Field | Rochester,New York |
| 2022-04-30 | April | Syracuse Mets | Home | L | 2-4 | boxscore | 4,229 | 2:05 | 12-11 | Frontier Field | Rochester,New York |
| 2022-05-01 | May | Syracuse Mets | Home | W | 8-3 | boxscore | 3,837 | 2:48 | 13-11 | Frontier Field | Rochester,New York |
| 2022-05-03 | May | Scranton/Wilkes-Barre RailRiders | Home | W | 2-0 | boxscore | 2,801 | 2:03 | 14-11 | Frontier Field | Rochester,New York |
| 2022-05-05 | May | Scranton/Wilkes-Barre RailRiders | Home | W | 2-0 | boxscore | 4,416 | 2:15 | 15-11 | Frontier Field | Rochester,New York |
| 2022-05-06 | May | Scranton/Wilkes-Barre RailRiders | Home | L | 7-8 | boxscore | 4,444 | 3:13 | 15-12 | Frontier Field | Rochester,New York |
| 2022-05-07 | May | Scranton/Wilkes-Barre RailRiders | Home | W | 9-2 | boxscore | 0 | 2:02 | 16-12 | Frontier Field | Rochester,New York |
| 2022-05-07 | May | Scranton/Wilkes-Barre RailRiders | Home | W | 7-6 | boxscore | 5,624 | 2:49 | 17-12 | Frontier Field | Rochester,New York |
| 2022-05-08 | May | Scranton/Wilkes-Barre RailRiders | Home | W | 2-1 | boxscore | 4,574 | 2:45 | 18-12 | Frontier Field | Rochester,New York |
| 2022-05-10 | May | Worcester Red Sox | Vis | W | 8-2 | boxscore | 6,071 | 2:32 | 19-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-11 | May | Worcester Red Sox | Vis | W | 3-2 | boxscore | 7,476 | 2:33 | 20-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-12 | May | Worcester Red Sox | Vis | W | 6-2 | boxscore | 6,730 | 2:32 | 21-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-13 | May | Worcester Red Sox | Vis | W | 6-4 | boxscore | 9,188 | 2:34 | 22-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-14 | May | Worcester Red Sox | Vis | W | 9-5 | boxscore | 9,042 | 3:17 | 23-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-15 | May | Worcester Red Sox | Vis | W | 7-4 | boxscore | 9,134 | 3:25 | 24-12 | Polar Park | Worcester,Massachusetts |
| 2022-05-17 | May | Lehigh Valley IronPigs | Home | L | 5-11 | boxscore | 3,181 | 2:56 | 24-13 | Frontier Field | Rochester,New York |
| 2022-05-18 | May | Lehigh Valley IronPigs | Home | L | 1-3 | boxscore | 3,197 | 2:53 | 24-14 | Frontier Field | Rochester,New York |
| 2022-05-19 | May | Lehigh Valley IronPigs | Home | W | 10-9 | boxscore | 6,386 | 2:54 | 25-14 | Frontier Field | Rochester,New York |
| 2022-05-20 | May | Lehigh Valley IronPigs | Home | L | 2-10 | boxscore | 7,831 | 2:34 | 25-15 | Frontier Field | Rochester,New York |
| 2022-05-21 | May | Lehigh Valley IronPigs | Home | W | 1-0 | boxscore | 9,168 | 1:37 | 26-15 | Frontier Field | Rochester,New York |
| 2022-05-22 | May | Lehigh Valley IronPigs | Home | L | 2-4 | boxscore | 4,672 | 2:29 | 26-16 | Frontier Field | Rochester,New York |
| 2022-05-24 | May | Syracuse Mets | Vis | W | 5-4 | boxscore | 3,761 | 2:26 | 27-16 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-25 | May | Syracuse Mets | Vis | L | 3-7 | boxscore | 10,815 | 2:28 | 27-17 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-26 | May | Syracuse Mets | Vis | W | 9-7 | boxscore | 5,188 | 3:04 | 28-17 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-27 | May | Syracuse Mets | Vis | W | 7-2 | boxscore | 3,591 | 2:36 | 29-17 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-28 | May | Syracuse Mets | Vis | W | 8-0 | boxscore | 6,019 | 2:14 | 30-17 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-29 | May | Syracuse Mets | Vis | W | 7-3 | boxscore | 7,022 | 2:41 | 31-17 | NBT Bank Stadium | Syracuse,New York |
| 2022-05-30 | May | Buffalo Bisons | Home | L | 5-7 | boxscore | 8,978 | 2:47 | 31-18 | Frontier Field | Rochester,New York |
| 2022-06-02 | June | Buffalo Bisons | Home | W | 6-1 | boxscore | 5,249 | 2:28 | 32-18 | Frontier Field | Rochester,New York |
| 2022-06-03 | June | Buffalo Bisons | Home | W | 2-1 | boxscore | 10,510 | 2:21 | 33-18 | Frontier Field | Rochester,New York |
| 2022-06-04 | June | Buffalo Bisons | Home | W | 5-1 | boxscore | 0 | 1:47 | 34-18 | Frontier Field | Rochester,New York |
| 2022-06-04 | June | Buffalo Bisons | Home | L | 0-13 | boxscore | 10,635 | 2:15 | 34-19 | Frontier Field | Rochester,New York |
| 2022-06-05 | June | Buffalo Bisons | Home | W | 11-2 | boxscore | 8,948 | 2:33 | 35-19 | Frontier Field | Rochester,New York |
| 2022-06-07 | June | St. Paul Saints | Vis | L | 6-10 | boxscore | 5,072 | 2:35 | 35-20 | CHS Field | St. Paul,Minnesota |
| 2022-06-08 | June | St. Paul Saints | Vis | L | 2-12 | boxscore | 5,513 | 2:48 | 35-21 | CHS Field | St. Paul,Minnesota |
| 2022-06-09 | June | St. Paul Saints | Vis | L | 3-4 | boxscore | 5,626 | 2:19 | 35-22 | CHS Field | St. Paul,Minnesota |
| 2022-06-10 | June | St. Paul Saints | Vis | L | 4-6 | boxscore | 9,061 | 2:43 | 35-23 | CHS Field | St. Paul,Minnesota |
| 2022-06-11 | June | St. Paul Saints | Vis | L | 7-11 | boxscore | 8,364 | 3:21 | 35-24 | CHS Field | St. Paul,Minnesota |
| 2022-06-12 | June | St. Paul Saints | Vis | L | 1-5 | boxscore | 8,325 | 2:23 | 35-25 | CHS Field | St. Paul,Minnesota |
| 2022-06-14 | June | Scranton/Wilkes-Barre RailRiders | Vis | L | 0-7 | boxscore | 4,099 | 2:26 | 35-26 | PNC Field | Moosic,Pennsylvania |
| 2022-06-15 | June | Scranton/Wilkes-Barre RailRiders | Vis | L | 6-10 | boxscore | 3,425 | 2:49 | 35-27 | PNC Field | Moosic,Pennsylvania |
| 2022-06-16 | June | Scranton/Wilkes-Barre RailRiders | Vis | W | 3-1 | boxscore | 3,644 | 2:34 | 36-27 | PNC Field | Moosic,Pennsylvania |
| 2022-06-17 | June | Scranton/Wilkes-Barre RailRiders | Vis | W | 7-6 | boxscore | 5,202 | 3:02 | 37-27 | PNC Field | Moosic,Pennsylvania |
| 2022-06-18 | June | Scranton/Wilkes-Barre RailRiders | Vis | L | 0-3 | boxscore | 6,148 | 2:07 | 37-28 | PNC Field | Moosic,Pennsylvania |
| 2022-06-19 | June | Scranton/Wilkes-Barre RailRiders | Vis | L | 4-5 | boxscore | 6,344 | 2:35 | 37-29 | PNC Field | Moosic,Pennsylvania |
| 2022-06-21 | June | Syracuse Mets | Home | L | 2-3 | boxscore | 6,502 | 2:40 | 37-30 | Frontier Field | Rochester,New York |
| 2022-06-22 | June | Syracuse Mets | Home | W | 4-2 | boxscore | 4,973 | 2:39 | 38-30 | Frontier Field | Rochester,New York |
| 2022-06-23 | June | Syracuse Mets | Home | W | 10-9 | boxscore | 5,893 | 3:28 | 39-30 | Frontier Field | Rochester,New York |
| 2022-06-24 | June | Syracuse Mets | Home | L | 2-3 | boxscore | 8,220 | 3:12 | 39-31 | Frontier Field | Rochester,New York |
| 2022-06-25 | June | Syracuse Mets | Home | L | 4-5 | boxscore | 8,316 | 2:42 | 39-32 | Frontier Field | Rochester,New York |
| 2022-06-26 | June | Syracuse Mets | Home | W | 2-1 | boxscore | 5,203 | 2:24 | 40-32 | Frontier Field | Rochester,New York |
| 2022-06-28 | June | Worcester Red Sox | Home | L | 2-4 | boxscore | 6,805 | 2:36 | 40-33 | Frontier Field | Rochester,New York |
| 2022-06-29 | June | Worcester Red Sox | Home | L | 5-6 | boxscore | 5,070 | 3:15 | 40-34 | Frontier Field | Rochester,New York |
| 2022-06-30 | June | Worcester Red Sox | Home | L | 6-8 | boxscore | 6,575 | 2:22 | 40-35 | Frontier Field | Rochester,New York |
| 2022-07-01 | July | Worcester Red Sox | Home | L | 4-5 | boxscore | 5,202 | 2:44 | 40-36 | Frontier Field | Rochester,New York |
| 2022-07-02 | July | Worcester Red Sox | Home | L | 0-10 | boxscore | 6,547 | 2:39 | 40-37 | Frontier Field | Rochester,New York |
| 2022-07-03 | July | Worcester Red Sox | Home | W | 9-8 | boxscore | 10,063 | 3:02 | 41-37 | Frontier Field | Rochester,New York |
| 2022-07-04 | July | Lehigh Valley IronPigs | Vis | L | 1-5 | boxscore | 8,405 | 2:26 | 41-38 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-06 | July | Lehigh Valley IronPigs | Vis | W | 4-0 | boxscore | 6,272 | 2:28 | 42-38 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-07 | July | Lehigh Valley IronPigs | Vis | W | 11-2 | boxscore | 6,897 | 2:54 | 43-38 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-08 | July | Lehigh Valley IronPigs | Vis | L | 5-6 | boxscore | 8,411 | 3:05 | 43-39 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-09 | July | Lehigh Valley IronPigs | Vis | L | 1-9 | boxscore | 9,088 | 2:58 | 43-40 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-10 | July | Lehigh Valley IronPigs | Vis | W | 2-0 | boxscore | 6,245 | 2:40 | 44-40 | Coca-Cola Park | Allentown,Pennsylvania |
| 2022-07-12 | July | Omaha Storm Chasers | Home | W | 5-2 | boxscore | 6,790 | 2:49 | 45-40 | Frontier Field | Rochester,New York |
| 2022-07-13 | July | Omaha Storm Chasers | Home | L | 1-6 | boxscore | 7,388 | 2:52 | 45-41 | Frontier Field | Rochester,New York |
| 2022-07-14 | July | Omaha Storm Chasers | Home | W | 4-1 | boxscore | 5,151 | 2:10 | 46-41 | Frontier Field | Rochester,New York |
| 2022-07-15 | July | Omaha Storm Chasers | Home | W | 3-0 | boxscore | 7,216 | 2:13 | 47-41 | Frontier Field | Rochester,New York |
| 2022-07-16 | July | Omaha Storm Chasers | Home | L | 1-4 | boxscore | 8,616 | 2:35 | 47-42 | Frontier Field | Rochester,New York |
| 2022-07-17 | July | Omaha Storm Chasers | Home | L | 7-13 | boxscore | 4,981 | 2:56 | 47-43 | Frontier Field | Rochester,New York |
| 2022-07-22 | July | Buffalo Bisons | Vis | L | 0-3 | boxscore | 13,741 | 2:33 | 47-44 | Sahlen Field | Buffalo,New York |
| 2022-07-23 | July | Buffalo Bisons | Vis | L | 9-10 | boxscore | 8,821 | 3:30 | 47-45 | Sahlen Field | Buffalo,New York |
| 2022-07-24 | July | Buffalo Bisons | Vis | L | 0-1 | boxscore | 5,947 | 2:11 | 47-46 | Sahlen Field | Buffalo,New York |
| 2022-07-26 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 5-12 | boxscore | 7,475 | 3:00 | 47-47 | Frontier Field | Rochester,New York |
| 2022-07-27 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 4-7 | boxscore | 8,906 | 3:01 | 47-48 | Frontier Field | Rochester,New York |
| 2022-07-29 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 6-8 | boxscore | 5,986 | 2:43 | 47-50 | Frontier Field | Rochester,New York |
| 2022-07-29 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 9-10 | boxscore | 9,207 | 2:16 | 47-50 | Frontier Field | Rochester,New York |
| 2022-07-30 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 4-7 | boxscore | 8,950 | 2:46 | 47-51 | Frontier Field | Rochester,New York |
| 2022-07-31 | July | Scranton/Wilkes-Barre RailRiders | Home | L | 2-9 | boxscore | 7,377 | 2:47 | 47-52 | Frontier Field | Rochester,New York |
| 2022-08-02 | August | Columbus Clippers | Vis | L | 0-2 | boxscore | 10,100 | 2:22 | 47-53 | Huntington Park | Columbus,Ohio |
| 2022-08-03 | August | Columbus Clippers | Vis | L | 2-3 | boxscore | 8,282 | 2:57 | 47-54 | Huntington Park | Columbus,Ohio |
| 2022-08-04 | August | Columbus Clippers | Vis | L | 5-6 | boxscore | 8,256 | 2:53 | 47-55 | Huntington Park | Columbus,Ohio |
| 2022-08-05 | August | Columbus Clippers | Vis | L | 5-8 | boxscore | 8,008 | 2:59 | 47-56 | Huntington Park | Columbus,Ohio |
| 2022-08-06 | August | Columbus Clippers | Vis | L | 1-3 | boxscore | 9,048 | 2:12 | 47-57 | Huntington Park | Columbus,Ohio |
| 2022-08-07 | August | Columbus Clippers | Vis | L | 2-3 | boxscore | 9,538 | 2:20 | 47-58 | Huntington Park | Columbus,Ohio |
| 2022-08-09 | August | Norfolk Tides | Home | L | 4-11 | boxscore | 7,215 | 2:57 | 47-59 | Frontier Field | Rochester,New York |
| 2022-08-10 | August | Norfolk Tides | Home | L | 8-9 | boxscore | 6,892 | 3:21 | 47-60 | Frontier Field | Rochester,New York |
| 2022-08-11 | August | Norfolk Tides | Home | W | 5-4 | boxscore | 5,359 | 2:28 | 48-60 | Frontier Field | Rochester,New York |
| 2022-08-12 | August | Norfolk Tides | Home | W | 12-5 | boxscore | 8,556 | 3:07 | 49-60 | Frontier Field | Rochester,New York |
| 2022-08-13 | August | Norfolk Tides | Home | W | 5-1 | boxscore | 8,210 | 2:18 | 50-60 | Frontier Field | Rochester,New York |
| 2022-08-14 | August | Norfolk Tides | Home | L | 7-12 | boxscore | 6,569 | 3:06 | 50-61 | Frontier Field | Rochester,New York |
| 2022-08-16 | August | Worcester Red Sox | Vis | W | 4-1 | boxscore | 7,449 | 2:28 | 51-61 | Polar Park | Worcester,Massachusetts |
| 2022-08-17 | August | Worcester Red Sox | Vis | L | 1-2 | boxscore | 7,292 | 3:09 | 51-62 | Polar Park | Worcester,Massachusetts |
| 2022-08-18 | August | Worcester Red Sox | Vis | L | 8-9 | boxscore | 7,110 | 3:06 | 51-63 | Polar Park | Worcester,Massachusetts |
| 2022-08-19 | August | Worcester Red Sox | Vis | L | 3-9 | boxscore | 7,949 | 3:09 | 51-64 | Polar Park | Worcester,Massachusetts |
| 2022-08-20 | August | Worcester Red Sox | Vis | W | 5-1 | boxscore | 7,690 | 2:16 | 52-64 | Polar Park | Worcester,Massachusetts |
| 2022-08-21 | August | Worcester Red Sox | Vis | W | 3-2 | boxscore | 7,611 | 2:34 | 53-64 | Polar Park | Worcester,Massachusetts |
| 2022-08-23 | August | Indianapolis Indians | Vis | L | 2-3 | boxscore | 6,433 | 2:23 | 53-65 | Victory Field | Indianapolis,Indiana |
| 2022-08-24 | August | Indianapolis Indians | Vis | W | 3-1 | boxscore | 4,408 | 2:20 | 54-65 | Victory Field | Indianapolis,Indiana |
| 2022-08-25 | August | Indianapolis Indians | Vis | L | 4-14 | boxscore | 5,575 | 2:58 | 54-66 | Victory Field | Indianapolis,Indiana |
| 2022-08-26 | August | Indianapolis Indians | Vis | L | 1-9 | boxscore | 8,959 | 2:43 | 54-67 | Victory Field | Indianapolis,Indiana |
| 2022-08-27 | August | Indianapolis Indians | Vis | L | 3-5 | boxscore | 8,147 | 3:01 | 54-68 | Victory Field | Indianapolis,Indiana |
| 2022-08-28 | August | Indianapolis Indians | Vis | W | 5-2 | boxscore | 7,798 | 2:30 | 55-68 | Victory Field | Indianapolis,Indiana |
| 2022-08-30 | August | Toledo Mud Hens | Home | L | 0-3 | boxscore | 5,474 | 2:42 | 55-69 | Frontier Field | Rochester,New York |
| 2022-08-31 | August | Toledo Mud Hens | Home | L | 4-5 | boxscore | 5,242 | 2:23 | 55-70 | Frontier Field | Rochester,New York |
| 2022-09-01 | September | Toledo Mud Hens | Home | W | 17-0 | boxscore | 5,649 | 3:02 | 56-70 | Frontier Field | Rochester,New York |
| 2022-09-02 | September | Toledo Mud Hens | Home | L | 4-5 | boxscore | 6,191 | 2:49 | 56-71 | Frontier Field | Rochester,New York |
| 2022-09-03 | September | Toledo Mud Hens | Home | L | 2-5 | boxscore | 6,219 | 2:31 | 56-72 | Frontier Field | Rochester,New York |
| 2022-09-04 | September | Toledo Mud Hens | Home | L | 3-6 | boxscore | 5,276 | 3:17 | 56-73 | Frontier Field | Rochester,New York |
| 2022-09-06 | September | Syracuse Mets | Vis | W | 3-2 | boxscore | 2,221 | 2:43 | 57-73 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-07 | September | Syracuse Mets | Vis | W | 15-8 | boxscore | 2,441 | 2:58 | 58-73 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-08 | September | Syracuse Mets | Vis | L | 1-2 | boxscore | 4,652 | 2:26 | 58-74 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-09 | September | Syracuse Mets | Vis | L | 3-8 | boxscore | 5,788 | 2:34 | 58-75 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-10 | September | Syracuse Mets | Vis | L | 4-5 | boxscore | 6,266 | 2:42 | 58-76 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-11 | September | Syracuse Mets | Vis | W | 7-2 | boxscore | 3,694 | 2:37 | 59-76 | NBT Bank Stadium | Syracuse,New York |
| 2022-09-13 | September | Lehigh Valley IronPigs | Home | W | 5-3 | boxscore | 3,658 | 2:43 | 60-76 | Frontier Field | Rochester,New York |
| 2022-09-14 | September | Lehigh Valley IronPigs | Home | W | 10-3 | boxscore | 4,086 | 2:39 | 61-76 | Frontier Field | Rochester,New York |
| 2022-09-15 | September | Lehigh Valley IronPigs | Home | W | 2-1 | boxscore | 5,760 | 3:07 | 62-76 | Frontier Field | Rochester,New York |
| 2022-09-16 | September | Lehigh Valley IronPigs | Home | W | 5-1 | boxscore | 7,629 | 2:44 | 63-76 | Frontier Field | Rochester,New York |
| 2022-09-17 | September | Lehigh Valley IronPigs | Home | L | 3-4 | boxscore | 8,774 | 2:35 | 63-77 | Frontier Field | Rochester,New York |
| 2022-09-18 | September | Lehigh Valley IronPigs | Home | W | 12-2 | boxscore | 6,327 | 2:44 | 64-77 | Frontier Field | Rochester,New York |
| 2022-09-20 | September | Buffalo Bisons | Vis | L | 2-3 | boxscore | 5,266 | 2:47 | 64-78 | Sahlen Field | Buffalo,New York |
| 2022-09-21 | September | Buffalo Bisons | Vis | W | 7-3 | boxscore | 4,112 | 2:41 | 65-78 | Sahlen Field | Buffalo,New York |
| 2022-09-22 | September | Buffalo Bisons | Vis | L | 2-10 | boxscore | 4,285 | 2:57 | 65-79 | Sahlen Field | Buffalo,New York |
| 2022-09-23 | September | Buffalo Bisons | Vis | W | 5-2 | boxscore | 9,668 | 2:45 | 66-79 | Sahlen Field | Buffalo,New York |
| 2022-09-24 | September | Buffalo Bisons | Vis | W | 7-4 | boxscore | 7,194 | 2:44 | 67-79 | Sahlen Field | Buffalo,New York |
| 2022-09-26 | September | Worcester Red Sox | Home | L | 1-6 | boxscore | 5,196 | 1:36 | 67-80 | Frontier Field | Rochester,New York |
| 2022-09-27 | September | Worcester Red Sox | Home | L | 6-8 | boxscore | 4,913 | 2:53 | 67-81 | Frontier Field | Rochester,New York |
| 148 record(s) |