| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 11 | Jose Ramirez | 28 | 3B | B | 120 | 152 | 552 | 111 | 147 | 32 | 5 | 36 | 103 | 27 | 4 | 72 | 87 | 7 | 0 | 5 | 10 | 13 | 297 | 636 | 73 | 74 | .266 | .355 | .538 | .893 | .444 | .272 | .256 | 11.32 | 13.68 | 1.21 | 15.33 | 2009- UDFA -CLE | premium | premium | premium | MLB | 2013-2025 | 2011-2025 | 2021 |
| 1 | Amed Rosario | 25 | SS | R | 101 | 141 | 550 | 77 | 155 | 25 | 6 | 11 | 57 | 13 | 0 | 31 | 120 | 3 | 0 | 4 | 0 | 12 | 225 | 588 | 42 | 113 | .282 | .321 | .409 | .730 | .207 | .127 | .340 | 5.27 | 20.41 | 3.87 | 50.00 | 2012- UDFA -NYN | premium | premium | premium | MLB | 2017-2025 | 2013-2025 | 2021 |
| 32 | Franmil Reyes | 25 | DH | R | 113 | 115 | 418 | 57 | 106 | 18 | 2 | 30 | 85 | 4 | 1 | 43 | 149 | 2 | 0 | 3 | 3 | 13 | 218 | 466 | 50 | 56 | .254 | .324 | .522 | .846 | .378 | .268 | .314 | 9.23 | 31.97 | 3.47 | 13.93 | 2011- UDFA -SDN | premium | premium | premium | MLB | 2018-2023 | 2012-2025 | 2021 |
| 7 | Cesar Hernandez | 31 | 2B | B | 96 | 96 | 376 | 60 | 87 | 17 | 2 | 18 | 47 | 0 | 0 | 38 | 90 | 4 | 0 | 2 | 0 | 6 | 162 | 420 | 37 | 50 | .231 | .307 | .431 | .738 | .301 | .200 | .256 | 9.05 | 21.43 | 2.37 | 20.89 | 2006- UDFA -PHI | premium | premium | premium | MLB | 2013-2022 | 2009-2023 | 2021 |
| 10 | Harold Ramirez | 26 | LF-RF | R | 96 | 99 | 339 | 33 | 91 | 21 | 1 | 7 | 41 | 3 | 1 | 14 | 56 | 5 | 0 | 3 | 1 | 10 | 135 | 361 | 29 | 62 | .268 | .305 | .398 | .703 | .177 | .130 | .301 | 3.88 | 15.51 | 4.00 | 48.43 | 2011- UDFA -PIT | premium | premium | premium | MLB | 2019-2024 | 2012-2025 | 2021 |
| 4 | Bradley Zimmer | 28 | CF-RF | L | 96 | 99 | 299 | 44 | 68 | 9 | 1 | 8 | 35 | 15 | 3 | 30 | 122 | 15 | 0 | 4 | 0 | 3 | 103 | 348 | 18 | 50 | .227 | .325 | .344 | .669 | .258 | .117 | .347 | 8.62 | 35.06 | 4.07 | 37.38 | 2014- 1- 21-CLE | premium | premium | premium | MLB | 2017-2022 | 2012-2023 | 2021 |
| 17 | Austin Hedges | 28 | C | R | 72 | 88 | 286 | 32 | 51 | 7 | 0 | 10 | 31 | 1 | 0 | 15 | 87 | 1 | 7 | 3 | 1 | 7 | 88 | 312 | 17 | 34 | .178 | .220 | .308 | .528 | .185 | .130 | .214 | 4.81 | 27.88 | 5.80 | 28.60 | 2011- 2- 82-SDN | premium | premium | premium | MLB | 2015-2025 | 2011-2025 | 2021 |
| 9 | Eddie Rosario | 29 | LF | L | 101 | 78 | 283 | 29 | 72 | 15 | 1 | 7 | 46 | 9 | 2 | 17 | 47 | 1 | 2 | 3 | 0 | 3 | 110 | 306 | 23 | 49 | .254 | .296 | .389 | .685 | .219 | .135 | .280 | 5.56 | 15.36 | 2.76 | 40.43 | 2010- 4- 135-MIN | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 |
| 44 | Bobby Bradley | 25 | 1B | L | 100 | 74 | 245 | 36 | 51 | 10 | 0 | 16 | 41 | 0 | 0 | 25 | 99 | 6 | 0 | 3 | 1 | 3 | 109 | 279 | 26 | 25 | .208 | .294 | .445 | .739 | .339 | .237 | .263 | 8.96 | 35.48 | 3.96 | 15.31 | 2014- 3- 97-CLE | premium | premium | premium | MLB | 2019-2022 | 2014-2025 | 2021 |
| 7 | Myles Straw | 26 | CF | R | 100 | 60 | 239 | 42 | 68 | 16 | 0 | 2 | 14 | 13 | 1 | 29 | 50 | 0 | 0 | 0 | 0 | 6 | 90 | 268 | 18 | 50 | .285 | .362 | .377 | .739 | .264 | .092 | .353 | 10.82 | 18.66 | 1.72 | 119.50 | 2015- 12- 349-HOU | premium | premium | premium | MLB | 2018-2025 | 2014-2025 | 2021 |
| 2 | Yu Chang | 25 | 1B | R | 94 | 89 | 237 | 32 | 54 | 14 | 3 | 9 | 39 | 1 | 0 | 11 | 69 | 2 | 0 | 1 | 0 | 4 | 101 | 251 | 26 | 28 | .228 | .267 | .426 | .693 | .249 | .198 | .281 | 4.38 | 27.49 | 6.27 | 26.33 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2019-2023 | 2014-2024 | 2021 |
| 22 | Josh Naylor | 24 | RF | L | 96 | 69 | 233 | 28 | 59 | 13 | 0 | 7 | 21 | 1 | 0 | 14 | 45 | 2 | 0 | 0 | 1 | 7 | 93 | 249 | 20 | 39 | .253 | .301 | .399 | .700 | .210 | .146 | .287 | 5.62 | 18.07 | 3.21 | 33.29 | 2015- 1- 12-MIA | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 |
| 35 | Oscar Mercado | 26 | LF | R | 94 | 72 | 214 | 27 | 48 | 11 | 1 | 6 | 19 | 7 | 1 | 21 | 42 | 2 | 1 | 0 | 0 | 1 | 79 | 238 | 18 | 30 | .224 | .300 | .369 | .669 | .271 | .145 | .253 | 8.82 | 17.65 | 2.00 | 35.67 | 2013- 2- 57-SLN | premium | premium | premium | MLB | 2019-2023 | 2013-2025 | 2021 |
| 6 | Owen Miller | 24 | 2B-1B | R | 77 | 60 | 191 | 17 | 39 | 8 | 0 | 4 | 18 | 2 | 0 | 9 | 54 | 1 | 0 | 1 | 0 | 7 | 59 | 202 | 12 | 27 | .204 | .243 | .309 | .552 | .162 | .105 | .261 | 4.46 | 26.73 | 6.00 | 47.75 | 2018- 3- 84-SDN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 0 | Andres Gimenez | 22 | SS-2B | L | 91 | 68 | 188 | 23 | 41 | 10 | 0 | 5 | 16 | 11 | 0 | 11 | 54 | 7 | 1 | 3 | 0 | 1 | 66 | 210 | 15 | 26 | .218 | .282 | .351 | .633 | .250 | .133 | .273 | 5.24 | 25.71 | 4.91 | 37.60 | 2015- UDFA -NYN | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 |
| 55 | Roberto Perez | 32 | C | R | 80* | 44 | 141 | 13 | 21 | 3 | 0 | 7 | 17 | 1 | 0 | 17 | 56 | 1 | 2 | 0 | 0 | 1 | 45 | 161 | 10 | 11 | .149 | .245 | .319 | .564 | .298 | .170 | .179 | 10.56 | 34.78 | 3.29 | 20.14 | 2008- 33-1011-CLE | premium | premium | premium | MLB | 2014-2023 | 2009-2025 | 2021 |
| 28 | Ernie Clement | 25 | 2B-3B | R | 86* | 40 | 121 | 16 | 28 | 4 | 0 | 3 | 9 | 0 | 1 | 7 | 19 | 2 | 3 | 0 | 0 | 3 | 41 | 133 | 7 | 21 | .231 | .285 | .339 | .624 | .157 | .108 | .253 | 5.26 | 14.29 | 2.71 | 40.33 | 2017- 4- 132-CLE | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 5 | Jake Bauers | 25 | 1B | L | 82 | 43 | 100 | 7 | 19 | 3 | 0 | 2 | 6 | 0 | 1 | 12 | 27 | 0 | 0 | 0 | 1 | 0 | 28 | 112 | 5 | 14 | .190 | .277 | .280 | .557 | .200 | .090 | .239 | 10.71 | 24.11 | 2.25 | 50.00 | 2013- 7- 208-SDN | premium | premium | premium | MLB | 2018-2025 | 2013-2025 | 2021 |
| 8 | Jordan Luplow | 27 | CF-RF | R | 106* | 36 | 98 | 12 | 17 | 5 | 0 | 7 | 20 | 0 | 2 | 21 | 31 | 2 | 0 | 0 | 0 | 1 | 43 | 121 | 12 | 5 | .173 | .331 | .439 | .770 | .459 | .266 | .167 | 17.36 | 25.62 | 1.48 | 14.00 | 2014- 3- 100-PIT | premium | premium | premium | MLB | 2017-2023 | 2012-2025 | 2021 |
| 23 | Daniel Johnson | 25 | RF | L | 30 | 77 | 9 | 17 | 0 | 0 | 4 | 5 | 1 | 0 | 4 | 27 | 0 | 0 | 0 | 0 | 0 | 29 | 81 | 4 | 13 | .221 | .259 | .377 | .636 | .221 | .156 | .283 | 4.94 | 33.33 | 6.75 | 19.25 | 2016- 5- 154-WAS | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 | |
| 46 | Rene Rivera | 37 | C | R | 21 | 55 | 6 | 13 | 3 | 0 | 2 | 9 | 0 | 0 | 4 | 24 | 1 | 3 | 0 | 0 | 2 | 22 | 63 | 5 | 8 | .236 | .300 | .400 | .700 | .236 | .164 | .379 | 6.35 | 38.10 | 6.00 | 27.50 | 2001- 2- 49-SEA | premium | premium | premium | MLB | 2004-2021 | 2001-2021 | 2021 | |
| 40 | Wilson Ramos | 33 | C | R | 88* | 9 | 31 | 3 | 7 | 0 | 0 | 2 | 7 | 0 | 0 | 3 | 7 | 0 | 0 | 1 | 0 | 1 | 13 | 35 | 2 | 5 | .226 | .286 | .419 | .705 | .290 | .193 | .217 | 8.57 | 20.00 | 2.33 | 15.50 | 2004- UDFA -MIN | premium | premium | premium | MLB | 2010-2021 | 2006-2023 | 2021 |
| 50 | Ryan Lavarnway | 33 | C | R | 9 | 28 | 2 | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 10 | 0 | 1 | 0 | 0 | 0 | 10 | 30 | 3 | 4 | .250 | .276 | .357 | .633 | .143 | .107 | .389 | 3.33 | 33.33 | 10.00 | 0.00 | 2008- 6- 202-BOS | premium | premium | premium | MLB | 2011-2021 | 2006-2023 | 2021 | |
| 18 | Ben Gamel | 29 | CF | L | 100 | 11 | 14 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 1 | 2 | 17 | 1 | 0 | .071 | .235 | .143 | .378 | .286 | .072 | .125 | 17.65 | 35.29 | 2.00 | 0.00 | 2010- 10- 325-NYA | premium | premium | premium | MLB | 2016-2024 | 2010-2025 | 2021 |
| 57 | Shane Bieber | 26 | P | R | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2016- 4- 122-CLE | premium | premium | premium | MLB | 2018-2025 | 2014-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 47 | Cal Quantrill | 26 | P | L | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | .500 | .500 | .500 | 1.000 | .000 | .000 | .500 | 0.00 | 0.00 | 0.00 | 0.00 | 2016- 1- 8-SDN | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 | |
| 49 | Eli Morgan | 25 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2017- 8- 252-CLE | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 | |
| 24 | Triston McKenzie | 23 | P | R | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | .500 | .500 | .500 | 1.000 | .000 | .000 | .500 | 0.00 | 0.00 | 0.00 | 0.00 | 2015- 1- 42-CLE | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 | |
| 88 | Phil Maton | 28 | P | R | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2015- 20- 597-SDN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 | |
| 43 | Aaron Civale | 26 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .500 | .000 | .500 | 1.000 | .000 | .000 | 50.00 | 50.00 | 1.00 | 0.00 | 2016- 3- 92-CLE | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 | |
| 36 | J.C. Mejia | 24 | P | R | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2014-2025 | 2021 | |
| 31 | Sam Hentges | 24 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2014- 4- 128-CLE | premium | premium | premium | MLB | 2021-2024 | 2014-2024 | 2021 | |
| 54 | Logan Allen | 24 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2015- 8- 231-BOS | premium | premium | premium | MLB | 2019-2024 | 2015-2024 | 2021 | |
| Totals: | 1619 | 5332 | 717 | 1269 | 248 | 22 | 203 | 686 | 109 | 17 | 453 | 1387 | 64 | 20 | 36 | 18 | 105 | 2170 | 5905 | 473 | 796 | .238 | .303 | .407 | .710 | .271 | .169 | .282 | 7.67 | 23.49 | 3.06 | 26.27 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 57 | Shane Bieber | 26 | R | 7 | 4 | 3.17 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 96.2 | 84 | 36 | 34 | 11 | 33 | 134 | 5 | 0 | 4 | 1.21 | 7.82 | 1.02 | 3.07 | 12.48 | 3.35 | 4.06 | 2016- 4- 122-CLE | premium | premium | premium | MLB | 2018-2025 | 2014-2025 | 2021 |
| 30 | Kyle Nelson | 24 | L | 0 | 0 | 9.31 | 10 | 0 | 0 | 0 | 10 | 4 | 0 | 9.2 | 10 | 10 | 10 | 0 | 8 | 8 | 0 | 0 | 2 | 1.86 | 9.31 | 0.00 | 7.45 | 7.45 | 9.31 | 1.00 | 2017- 15- 462-CLE | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 49 | Eli Morgan | 25 | R | 5 | 7 | 5.34 | 18 | 18 | 0 | 0 | 0 | 0 | 0 | 89.1 | 90 | 54 | 53 | 20 | 22 | 81 | 0 | 1 | 4 | 1.25 | 9.07 | 2.01 | 2.22 | 8.16 | 5.44 | 3.68 | 2017- 8- 252-CLE | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 27 | Bryan Shaw | 33 | R | 6 | 7 | 3.49 | 81 | 0 | 0 | 0 | 81 | 10 | 2 | 77.1 | 69 | 33 | 30 | 10 | 38 | 71 | 6 | 0 | 1 | 1.38 | 8.03 | 1.16 | 4.42 | 8.26 | 3.84 | 1.87 | 2008- 2- 73-ARI | premium | premium | premium | MLB | 2011-2024 | 2006-2025 | 2021 |
| 48 | Emmanuel Clase | 23 | R | 4 | 5 | 1.29 | 71 | 0 | 0 | 0 | 71 | 51 | 24 | 69.2 | 51 | 18 | 10 | 2 | 16 | 74 | 3 | 1 | 0 | 0.96 | 6.59 | 0.26 | 2.07 | 9.56 | 2.33 | 4.63 | 2015- UDFA -SDN | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 |
| 31 | Sam Hentges | 24 | L | 1 | 4 | 6.68 | 30 | 12 | 0 | 0 | 18 | 6 | 0 | 68.2 | 90 | 54 | 51 | 10 | 32 | 68 | 11 | 0 | 0 | 1.78 | 11.80 | 1.31 | 4.19 | 8.91 | 7.08 | 2.13 | 2014- 4- 128-CLE | premium | premium | premium | MLB | 2021-2024 | 2014-2024 | 2021 |
| 37 | Trevor Stephan | 25 | R | 3 | 1 | 4.41 | 43 | 0 | 0 | 0 | 43 | 13 | 1 | 63.1 | 58 | 32 | 31 | 15 | 31 | 75 | 0 | 0 | 3 | 1.41 | 8.24 | 2.13 | 4.41 | 10.66 | 4.55 | 2.42 | 2017- 3- 92-NYA | premium | premium | premium | MLB | 2021-2023 | 2015-2025 | 2021 |
| 62 | Nick Wittgren | 30 | R | 2 | 9 | 5.05 | 60 | 1 | 0 | 0 | 59 | 13 | 1 | 62.1 | 61 | 38 | 35 | 13 | 17 | 61 | 2 | 0 | 2 | 1.25 | 8.81 | 1.88 | 2.45 | 8.81 | 5.49 | 3.59 | 2012- 9- 287-MIA | premium | premium | premium | MLB | 2016-2023 | 2011-2024 | 2021 |
| 65 | Francisco Perez | 23 | L | 0 | 0 | 4.05 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 6.2 | 6 | 3 | 3 | 0 | 3 | 5 | 0 | 0 | 0 | 1.35 | 8.10 | 0.00 | 4.05 | 6.75 | 4.05 | 1.67 | 2014- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2015-2024 | 2021 |
| 26 | Anthony Gose | 30 | L | 0 | 0 | 1.35 | 6 | 0 | 0 | 0 | 6 | 0 | 0 | 6.2 | 2 | 1 | 1 | 0 | 2 | 9 | 0 | 0 | 0 | 0.60 | 2.70 | 0.00 | 2.70 | 12.15 | 1.35 | 4.50 | 2008- 2- 51-PHI | premium | premium | premium | MLB | 2012-2024 | 2008-2025 | 2021 |
| 99 | James Karinchak | 25 | R | 7 | 4 | 4.07 | 60 | 0 | 0 | 0 | 60 | 26 | 11 | 55.1 | 35 | 27 | 25 | 9 | 32 | 78 | 3 | 0 | 2 | 1.21 | 5.69 | 1.46 | 5.20 | 12.69 | 4.39 | 2.44 | 2017- 9- 282-CLE | premium | premium | premium | MLB | 2019-2023 | 2015-2025 | 2021 |
| 36 | J.C. Mejia | 24 | R | 1 | 7 | 8.25 | 17 | 11 | 0 | 0 | 6 | 1 | 0 | 52.1 | 60 | 48 | 48 | 13 | 24 | 47 | 2 | 2 | 3 | 1.61 | 10.32 | 2.24 | 4.13 | 8.08 | 8.25 | 1.96 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2014-2025 | 2021 |
| 54 | Logan Allen | 24 | L | 2 | 7 | 6.26 | 14 | 11 | 0 | 0 | 3 | 1 | 0 | 50.1 | 58 | 39 | 35 | 12 | 17 | 37 | 4 | 0 | 4 | 1.49 | 10.37 | 2.15 | 3.04 | 6.62 | 6.97 | 2.18 | 2015- 8- 231-BOS | premium | premium | premium | MLB | 2019-2024 | 2015-2024 | 2021 |
| 53 | Blake Parker | 36 | R | 2 | 1 | 3.09 | 47 | 0 | 0 | 0 | 47 | 13 | 0 | 43.2 | 43 | 15 | 15 | 5 | 14 | 37 | 1 | 0 | 2 | 1.31 | 8.86 | 1.03 | 2.89 | 7.63 | 3.09 | 2.64 | 2006- 16- 479-CHN | premium | premium | premium | MLB | 2012-2021 | 2004-2022 | 2021 |
| 88 | Phil Maton | 28 | R | 2 | 0 | 4.57 | 38 | 1 | 0 | 0 | 37 | 3 | 0 | 41.1 | 36 | 21 | 21 | 4 | 20 | 61 | 0 | 0 | 3 | 1.35 | 7.84 | 0.87 | 4.35 | 13.28 | 4.57 | 3.05 | 2015- 20- 597-SDN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 |
| 52 | Nick Sandlin | 24 | R | 1 | 1 | 2.94 | 34 | 0 | 0 | 0 | 34 | 4 | 0 | 33.2 | 21 | 15 | 11 | 2 | 17 | 48 | 1 | 0 | 4 | 1.13 | 5.61 | 0.53 | 4.54 | 12.83 | 4.01 | 2.82 | 2018- 2- 67-CLE | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 39 | Oliver Perez | 39 | L | 0 | 1 | 0.00 | 5 | 0 | 0 | 0 | 5 | 3 | 0 | 3.2 | 5 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 1.64 | 12.27 | 0.00 | 2.45 | 9.82 | 2.45 | 4.00 | 1999- UDFA -SDN | premium | premium | premium | MLB | 2002-2022 | 1999-2023 | 2021 |
| 63 | Justin Garza | 27 | R | 2 | 1 | 4.71 | 21 | 0 | 0 | 0 | 21 | 6 | 0 | 28.2 | 27 | 16 | 15 | 5 | 18 | 29 | 0 | 0 | 0 | 1.57 | 8.48 | 1.57 | 5.65 | 9.10 | 5.02 | 1.61 | 2015- 8- 244-CLE | premium | premium | premium | MLB | 2021-2025 | 2013-2025 | 2021 |
| 47 | Cal Quantrill | 26 | R | 8 | 3 | 2.89 | 40 | 22 | 0 | 0 | 18 | 2 | 0 | 149.2 | 129 | 55 | 48 | 16 | 47 | 121 | 3 | 0 | 9 | 1.18 | 7.76 | 0.96 | 2.83 | 7.28 | 3.31 | 2.57 | 2016- 1- 8-SDN | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 34 | Zach Plesac | 26 | R | 10 | 6 | 4.67 | 25 | 25 | 0 | 0 | 0 | 0 | 0 | 142.2 | 137 | 79 | 74 | 23 | 34 | 100 | 5 | 1 | 7 | 1.20 | 8.64 | 1.45 | 2.14 | 6.31 | 4.98 | 2.94 | 2016- 12- 362-CLE | premium | premium | premium | MLB | 2019-2024 | 2014-2025 | 2021 |
| 43 | Aaron Civale | 26 | R | 12 | 5 | 3.84 | 21 | 21 | 0 | 0 | 0 | 0 | 0 | 124.1 | 108 | 56 | 53 | 23 | 31 | 99 | 3 | 1 | 4 | 1.12 | 7.82 | 1.66 | 2.24 | 7.17 | 4.05 | 3.19 | 2016- 3- 92-CLE | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 24 | Triston McKenzie | 23 | R | 5 | 9 | 4.95 | 25 | 24 | 0 | 0 | 1 | 0 | 0 | 120.0 | 84 | 66 | 66 | 21 | 58 | 136 | 2 | 2 | 3 | 1.18 | 6.30 | 1.58 | 4.35 | 10.20 | 4.95 | 2.34 | 2015- 1- 42-CLE | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 46 | Alex Young | 27 | L | 0 | 0 | 7.84 | 10 | 0 | 0 | 0 | 10 | 5 | 0 | 10.1 | 15 | 9 | 9 | 1 | 7 | 5 | 1 | 0 | 2 | 2.13 | 13.06 | 0.87 | 6.10 | 4.35 | 7.84 | 0.71 | 2015- 2- 43-ARI | premium | premium | premium | MLB | 2019-2024 | 2013-2024 | 2021 |
| 23 | DJ Johnson | 31 | R | 0 | 0 | 5.40 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.2 | 2 | 1 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 1.20 | 10.80 | 5.40 | 0.00 | 16.20 | 5.40 | 0.00 | 2010- UDFA -TBA | premium | premium | premium | MLB | 2018-2021 | 2010-2025 | 2021 |
| Totals: | 80 | 82 | 4.34 | 697 | 162 | 0 | 0 | 162 | 535 | 39 | 1408.0 | 1281 | 727 | 679 | 216 | 522 | 1391 | 52 | 8 | 59 | 1.28 | 8.19 | 1.38 | 3.34 | 8.89 | 4.65 | 2.66 | premium | premium | premium |