| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 6 | Jonathan India | 24 | 2B | R | 115 | 150 | 532 | 98 | 143 | 34 | 2 | 21 | 69 | 12 | 3 | 71 | 141 | 23 | 1 | 4 | 1 | 13 | 244 | 631 | 57 | 86 | .269 | .376 | .459 | .835 | .340 | .190 | .326 | 11.25 | 22.35 | 1.99 | 25.33 | 2018- 1- 5-CIN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 2 | Nick Castellanos | 29 | RF | R | 125 | 138 | 531 | 95 | 164 | 38 | 1 | 34 | 100 | 3 | 1 | 41 | 121 | 7 | 0 | 6 | 5 | 16 | 306 | 585 | 73 | 91 | .309 | .362 | .576 | .938 | .348 | .267 | .340 | 7.01 | 20.68 | 2.95 | 15.62 | 2010- 1- 44-DET | premium | premium | premium | MLB | 2013-2025 | 2010-2025 | 2021 |
| 7 | Eugenio Suarez | 29 | 3B | R | 97 | 145 | 505 | 71 | 100 | 23 | 0 | 31 | 79 | 0 | 1 | 56 | 171 | 8 | 0 | 5 | 0 | 14 | 216 | 574 | 54 | 46 | .198 | .286 | .428 | .714 | .339 | .230 | .224 | 9.76 | 29.79 | 3.05 | 16.29 | 2008- UDFA -DET | premium | premium | premium | MLB | 2014-2025 | 2011-2025 | 2021 |
| 17 | Kyle Farmer | 30 | SS | R | 100 | 147 | 483 | 60 | 127 | 22 | 2 | 16 | 63 | 2 | 3 | 22 | 97 | 18 | 1 | 5 | 1 | 16 | 201 | 529 | 40 | 87 | .263 | .316 | .416 | .732 | .197 | .153 | .296 | 4.16 | 18.34 | 4.41 | 30.19 | 2013- 8- 244-LAN | premium | premium | premium | MLB | 2017-2025 | 2010-2025 | 2021 |
| 19 | Joey Votto | 37 | 1B | L | 125 | 129 | 448 | 73 | 119 | 23 | 1 | 36 | 99 | 1 | 0 | 77 | 127 | 4 | 0 | 4 | 6 | 7 | 252 | 533 | 60 | 59 | .266 | .375 | .563 | .938 | .471 | .297 | .287 | 14.45 | 23.83 | 1.65 | 12.44 | 2002- 2- 44-CIN | premium | premium | premium | MLB | 2007-2023 | 2002-2024 | 2021 |
| 33 | Jesse Winker | 27 | LF | L | 128 | 110 | 423 | 77 | 129 | 32 | 1 | 24 | 71 | 1 | 0 | 53 | 75 | 9 | 0 | 0 | 1 | 14 | 235 | 485 | 57 | 72 | .305 | .394 | .556 | .950 | .378 | .251 | .324 | 10.93 | 15.46 | 1.42 | 17.63 | 2012- 1- 49-CIN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 |
| 12 | Tyler Naquin | 30 | CF | L | 109 | 127 | 411 | 52 | 111 | 24 | 2 | 19 | 70 | 5 | 3 | 35 | 106 | 5 | 0 | 3 | 1 | 9 | 196 | 454 | 45 | 66 | .270 | .333 | .477 | .810 | .297 | .207 | .318 | 7.71 | 23.35 | 3.03 | 21.63 | 2012- 1- 15-CLE | premium | premium | premium | MLB | 2016-2023 | 2010-2025 | 2021 |
| 37 | Tyler Stephenson | 24 | C | R | 109 | 132 | 350 | 56 | 100 | 21 | 0 | 10 | 45 | 0 | 0 | 41 | 75 | 6 | 0 | 5 | 1 | 11 | 151 | 402 | 31 | 69 | .286 | .366 | .431 | .797 | .263 | .145 | .333 | 10.20 | 18.66 | 1.83 | 35.00 | 2015- 1- 11-CIN | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 16 | Tucker Barnhart | 30 | C | L | 95 | 116 | 348 | 41 | 86 | 21 | 0 | 7 | 48 | 0 | 0 | 29 | 100 | 8 | 0 | 3 | 1 | 8 | 128 | 388 | 28 | 58 | .247 | .317 | .368 | .685 | .204 | .121 | .324 | 7.47 | 25.77 | 3.45 | 49.71 | 2009- 10- 299-CIN | premium | premium | premium | MLB | 2014-2025 | 2009-2025 | 2021 |
| 9 | Mike Moustakas | 32 | 3B | L | 90 | 62 | 183 | 21 | 38 | 12 | 0 | 6 | 22 | 0 | 0 | 18 | 46 | 2 | 0 | 3 | 0 | 6 | 68 | 206 | 18 | 20 | .208 | .282 | .372 | .654 | .262 | .164 | .239 | 8.74 | 22.33 | 2.56 | 30.50 | 2007- 1- 2-KCA | premium | premium | premium | MLB | 2011-2023 | 2007-2023 | 2021 |
| 44 | Aristides Aquino | 27 | LF-RF | R | 96 | 84 | 174 | 25 | 33 | 6 | 1 | 10 | 23 | 2 | 2 | 27 | 75 | 1 | 0 | 2 | 2 | 0 | 71 | 204 | 17 | 16 | .190 | .299 | .408 | .707 | .374 | .218 | .253 | 13.24 | 36.76 | 2.78 | 17.40 | 2011- UDFA -CIN | premium | premium | premium | MLB | 2018-2022 | 2011-2025 | 2021 |
| 4 | Shogo Akiyama | 33 | CF | L | 75* | 88 | 162 | 16 | 33 | 8 | 0 | 0 | 12 | 2 | 3 | 14 | 40 | 4 | 1 | 1 | 1 | 1 | 41 | 182 | 8 | 25 | .204 | .282 | .253 | .535 | .130 | .049 | .268 | 7.69 | 21.98 | 2.86 | 0.00 | 2020- UDFA -CIN | premium | premium | premium | MLB | 2020-2021 | 2011-2025 | 2021 |
| 32 | Max Schrock | 26 | LF | L | 104* | 53 | 125 | 19 | 36 | 7 | 2 | 3 | 14 | 1 | 1 | 8 | 24 | 0 | 0 | 1 | 1 | 0 | 56 | 134 | 12 | 24 | .288 | .328 | .448 | .776 | .224 | .160 | .333 | 5.97 | 17.91 | 3.00 | 41.67 | 2015- 13- 404-WAS | premium | premium | premium | MLB | 2020-2022 | 2013-2023 | 2021 |
| 15 | Nick Senzel | 26 | CF | R | 86* | 36 | 111 | 18 | 28 | 4 | 0 | 1 | 8 | 2 | 5 | 12 | 16 | 0 | 0 | 1 | 0 | 3 | 35 | 124 | 5 | 23 | .252 | .323 | .315 | .638 | .144 | .063 | .284 | 9.68 | 12.90 | 1.33 | 111.00 | 2016- 1- 2-CIN | premium | premium | premium | MLB | 2019-2024 | 2014-2025 | 2021 |
| 0 | Alex Blandino | 28 | 1B-3B | R | 43 | 70 | 9 | 14 | 4 | 0 | 0 | 5 | 1 | 0 | 8 | 28 | 4 | 0 | 0 | 0 | 0 | 18 | 82 | 4 | 10 | .200 | .317 | .257 | .574 | .186 | .057 | .333 | 9.76 | 34.15 | 3.50 | 0.00 | 2014- 1- 29-CIN | premium | premium | premium | MLB | 2018-2021 | 2012-2024 | 2021 | |
| 27 | Mike Freeman | 33 | SS-1B | L | 37 | 59 | 6 | 11 | 0 | 0 | 0 | 3 | 1 | 1 | 5 | 20 | 1 | 0 | 0 | 1 | 1 | 11 | 65 | 0 | 11 | .186 | .262 | .186 | .448 | .085 | .000 | .282 | 7.69 | 30.77 | 4.00 | 0.00 | 2010- 11- 331-ARI | premium | premium | premium | MLB | 2016-2021 | 2007-2021 | 2021 | |
| 30 | Tyler Mahle | 26 | P | R | 32 | 55 | 1 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 19 | 0 | 7 | 0 | 0 | 2 | 3 | 66 | 0 | 3 | .055 | .119 | .055 | .174 | .073 | .000 | .083 | 6.06 | 28.79 | 4.75 | 0.00 | 2013- 7- 225-CIN | premium | premium | premium | MLB | 2017-2025 | 2013-2025 | 2021 | |
| 22 | Wade Miley | 34 | P | L | 28 | 54 | 9 | 10 | 3 | 0 | 0 | 3 | 0 | 0 | 3 | 13 | 0 | 2 | 0 | 0 | 0 | 13 | 59 | 3 | 7 | .185 | .228 | .241 | .469 | .111 | .056 | .244 | 5.08 | 22.03 | 4.33 | 0.00 | 2008- 1- 43-ARI | premium | premium | premium | MLB | 2011-2025 | 2006-2025 | 2021 | |
| 38 | Jose Barrero | 23 | SS-CF | R | 21 | 50 | 4 | 10 | 4 | 1 | 0 | 3 | 1 | 0 | 3 | 17 | 3 | 0 | 0 | 0 | 2 | 16 | 56 | 5 | 5 | .200 | .286 | .320 | .606 | .200 | .120 | .303 | 5.36 | 30.36 | 5.67 | 0.00 | 2017- UDFA -CIN | premium | premium | premium | MLB | 2020-2025 | 2018-2025 | 2021 | |
| 58 | Luis Castillo | 28 | P | R | 30 | 49 | 1 | 8 | 2 | 0 | 0 | 2 | 0 | 0 | 1 | 23 | 0 | 9 | 0 | 0 | 1 | 10 | 59 | 2 | 6 | .163 | .180 | .204 | .384 | .061 | .041 | .308 | 1.69 | 38.98 | 23.00 | 0.00 | 2012- UDFA -SFN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 | |
| 26 | Delino DeShields | 28 | CF | R | 25 | 47 | 4 | 12 | 5 | 0 | 1 | 6 | 2 | 1 | 9 | 11 | 0 | 2 | 0 | 0 | 0 | 20 | 58 | 6 | 6 | .255 | .375 | .426 | .801 | .383 | .171 | .314 | 15.52 | 18.97 | 1.22 | 47.00 | 2010- 1- 8-HOU | premium | premium | premium | MLB | 2015-2021 | 2010-2025 | 2021 | |
| 54 | Sonny Gray | 31 | P | R | 24 | 41 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 10 | 0 | 1 | 0 | 0 | 1 | 6 | 43 | 0 | 6 | .146 | .167 | .146 | .313 | .024 | .000 | .194 | 2.33 | 23.26 | 10.00 | 0.00 | 2011- 1- 18-OAK | premium | premium | premium | MLB | 2013-2025 | 2009-2025 | 2021 | |
| 53 | Vladimir Gutierrez | 25 | P | R | 21 | 33 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 14 | 0 | 7 | 0 | 0 | 0 | 3 | 42 | 0 | 3 | .091 | .143 | .091 | .234 | .061 | .000 | .158 | 4.76 | 33.33 | 7.00 | 0.00 | 2016- UDFA -CIN | premium | premium | premium | MLB | 2021-2024 | 2017-2025 | 2021 | |
| 29 | TJ Friedl | 25 | CF-LF | L | 14 | 31 | 9 | 9 | 1 | 0 | 1 | 2 | 0 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 0 | 13 | 36 | 2 | 7 | .290 | .361 | .419 | .780 | .258 | .129 | .276 | 11.11 | 5.56 | 0.50 | 31.00 | 2016- UDFA -CIN | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 | |
| 26 | Scott Heineman | 28 | CF | R | 19 | 30 | 5 | 3 | 0 | 0 | 2 | 3 | 0 | 0 | 3 | 15 | 1 | 0 | 0 | 0 | 1 | 9 | 34 | 2 | 1 | .100 | .206 | .300 | .506 | .300 | .200 | .077 | 8.82 | 44.12 | 5.00 | 15.00 | 2015- 11- 318-TEX | premium | premium | premium | MLB | 2019-2021 | 2012-2022 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 3 | Asdrubal Cabrera | 35 | 3B-1B | B | 94 | 20 | 26 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 3 | 7 | 1 | 0 | 1 | 0 | 2 | 2 | 31 | 0 | 2 | .077 | .194 | .077 | .271 | .115 | .000 | .100 | 9.68 | 22.58 | 2.33 | 0.00 | 2002- UDFA -SEA | premium | premium | premium | MLB | 2007-2021 | 2004-2021 | 2021 |
| 28 | Alejo Lopez | 25 | 3B-2B | B | 14 | 23 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 6 | 23 | 0 | 6 | .261 | .261 | .261 | .522 | .000 | .000 | .333 | 0.00 | 21.74 | 0.00 | 0.00 | 2015- 27- 805-CIN | premium | premium | premium | MLB | 2021-2023 | 2015-2025 | 2021 | |
| 34 | Mark Payton | 29 | RF | L | 24 | 22 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 4 | 24 | 0 | 4 | .182 | .250 | .182 | .432 | .091 | .000 | .267 | 8.33 | 29.17 | 3.50 | 0.00 | 2014- 7- 212-NYA | premium | premium | premium | MLB | 2020-2022 | 2011-2025 | 2021 | |
| 23 | Jeff Hoffman | 28 | P | R | 30 | 15 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 2 | 16 | 0 | 2 | .133 | .133 | .133 | .266 | .000 | .000 | .167 | 0.00 | 18.75 | 0.00 | 0.00 | 2014- 1- 9-TOR | premium | premium | premium | MLB | 2016-2025 | 2012-2025 | 2021 | |
| 64 | Tony Santillan | 24 | P | R | 26 | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 8 | 1 | 0 | .143 | .143 | .286 | .429 | .143 | .143 | .200 | 0.00 | 25.00 | 0.00 | 0.00 | 2015- 2- 49-CIN | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 | |
| 52 | Reiver Sanmartin | 25 | P | L | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 83.33 | 0.00 | 0.00 | 2015- UDFA -TEX | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 | |
| 87 | Jose De Leon | 28 | P | R | 9 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 5 | 0 | 1 | .250 | .250 | .250 | .500 | .000 | .000 | .500 | 0.00 | 40.00 | 0.00 | 0.00 | 2013- 24- 724-LAN | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 | |
| 70 | Tejay Antone | 27 | P | R | 22 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | .000 | .250 | .000 | .250 | .333 | .000 | .000 | 20.00 | 60.00 | 3.00 | 0.00 | 2014- 5- 155-CIN | premium | premium | premium | MLB | 2020-2024 | 2013-2025 | 2021 | |
| 43 | Cionel Perez | 25 | P | R | 23 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2016- UDFA -HOU | premium | premium | premium | MLB | 2018-2025 | 2017-2025 | 2021 | |
| 41 | Carson Fulmer | 27 | P | R | 19 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2015- 1- 8-CHA | premium | premium | premium | MLB | 2016-2025 | 2013-2025 | 2021 | |
| 39 | Lucas Sims | 27 | P | R | 44 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2012- 1- 21-ATL | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 | |
| 48 | Sal Romano | 27 | P | L | 13 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2011- 23- 715-CIN | premium | premium | premium | MLB | 2017-2021 | 2012-2025 | 2021 | |
| 68 | Ryan Hendrix | 26 | P | R | 33 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2016- 5- 138-CIN | premium | premium | premium | MLB | 2021-2022 | 2014-2025 | 2021 | |
| 53 | Heath Hembree | 32 | P | R | 42 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2010- 5- 168-SFN | premium | premium | premium | MLB | 2013-2023 | 2008-2024 | 2021 | |
| 21 | Michael Lorenzen | 29 | P | R | 26 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2013- 1- 38-CIN | premium | premium | premium | MLB | 2015-2025 | 2011-2025 | 2021 | |
| 51 | R.J. Alaniz | 30 | P | R | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2009- UDFA -HOU | premium | premium | premium | MLB | 2019-2021 | 2010-2025 | 2021 | |
| Totals: | 2161 | 5423 | 786 | 1352 | 295 | 13 | 222 | 756 | 36 | 24 | 553 | 1425 | 105 | 35 | 45 | 22 | 129 | 2339 | 6161 | 530 | 822 | .249 | .328 | .431 | .759 | .286 | .182 | .296 | 8.98 | 23.13 | 2.58 | 24.43 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 75 | Ashton Goudeau | 28 | R | 0 | 0 | 4.00 | 5 | 0 | 0 | 0 | 5 | 2 | 0 | 9.0 | 8 | 4 | 4 | 1 | 9 | 5 | 0 | 0 | 0 | 1.89 | 8.00 | 1.00 | 9.00 | 5.00 | 4.00 | 0.56 | 2012- 27- 823-KCA | premium | premium | premium | MLB | 2020-2022 | 2012-2025 | 2021 |
| 23 | Jeff Hoffman | 28 | R | 3 | 5 | 4.56 | 31 | 11 | 0 | 0 | 20 | 7 | 0 | 73.0 | 70 | 41 | 37 | 12 | 45 | 79 | 9 | 0 | 5 | 1.58 | 8.63 | 1.48 | 5.55 | 9.74 | 5.05 | 1.76 | 2014- 1- 9-TOR | premium | premium | premium | MLB | 2016-2025 | 2012-2025 | 2021 |
| 48 | Michael Feliz | 28 | R | 0 | 0 | 16.20 | 9 | 0 | 0 | 0 | 9 | 5 | 1 | 6.2 | 13 | 12 | 12 | 2 | 4 | 9 | 1 | 0 | 0 | 2.55 | 17.55 | 2.70 | 5.40 | 12.15 | 16.20 | 2.25 | 2010- UDFA -HOU | premium | premium | premium | MLB | 2015-2022 | 2010-2025 | 2021 |
| 46 | Cam Bedrosian | 29 | R | 0 | 0 | 11.12 | 6 | 0 | 0 | 0 | 6 | 2 | 0 | 5.2 | 10 | 7 | 7 | 2 | 6 | 7 | 0 | 0 | 0 | 2.82 | 15.88 | 3.18 | 9.53 | 11.12 | 11.12 | 1.17 | 2010- 1- 29-ANA | premium | premium | premium | MLB | 2014-2021 | 2010-2024 | 2021 |
| 50 | Amir Garrett | 29 | L | 0 | 4 | 6.04 | 63 | 0 | 0 | 0 | 63 | 22 | 7 | 47.2 | 46 | 34 | 32 | 9 | 29 | 61 | 5 | 1 | 0 | 1.57 | 8.69 | 1.70 | 5.48 | 11.52 | 6.42 | 2.10 | 2011- 22- 685-CIN | premium | premium | premium | MLB | 2017-2024 | 2012-2025 | 2021 |
| 39 | Lucas Sims | 27 | R | 5 | 3 | 4.40 | 47 | 0 | 0 | 0 | 47 | 13 | 7 | 47.0 | 34 | 26 | 23 | 6 | 18 | 76 | 2 | 1 | 4 | 1.11 | 6.51 | 1.15 | 3.45 | 14.55 | 4.98 | 4.22 | 2012- 1- 21-ATL | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 |
| 64 | Tony Santillan | 24 | R | 1 | 3 | 2.91 | 26 | 4 | 0 | 0 | 22 | 5 | 0 | 43.1 | 34 | 15 | 14 | 7 | 21 | 56 | 1 | 0 | 7 | 1.27 | 7.06 | 1.45 | 4.36 | 11.63 | 3.12 | 2.67 | 2015- 2- 49-CIN | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 53 | Heath Hembree | 32 | R | 2 | 7 | 6.38 | 45 | 0 | 0 | 0 | 45 | 16 | 8 | 42.1 | 32 | 33 | 30 | 10 | 19 | 68 | 1 | 0 | 2 | 1.20 | 6.80 | 2.13 | 4.04 | 14.46 | 7.02 | 3.58 | 2010- 5- 168-SFN | premium | premium | premium | MLB | 2013-2023 | 2008-2024 | 2021 |
| 52 | Edgar Garcia | 24 | R | 0 | 1 | 16.62 | 5 | 0 | 0 | 0 | 5 | 1 | 0 | 4.1 | 10 | 10 | 8 | 2 | 1 | 4 | 1 | 0 | 0 | 2.54 | 20.77 | 4.15 | 2.08 | 8.31 | 20.77 | 4.00 | 2014- UDFA -PHI | premium | premium | premium | MLB | 2019-2021 | 2014-2024 | 2021 |
| 62 | Sean Doolittle | 34 | L | 3 | 1 | 4.46 | 45 | 0 | 0 | 0 | 45 | 11 | 1 | 38.1 | 40 | 21 | 19 | 6 | 18 | 41 | 0 | 0 | 1 | 1.51 | 9.39 | 1.41 | 4.23 | 9.63 | 4.93 | 2.28 | 2007- 1- 41-OAK | premium | premium | premium | MLB | 2012-2022 | 2005-2023 | 2021 |
| 70 | Tejay Antone | 27 | R | 2 | 0 | 2.14 | 23 | 0 | 0 | 0 | 23 | 4 | 3 | 33.2 | 17 | 8 | 8 | 3 | 13 | 42 | 1 | 0 | 3 | 0.89 | 4.54 | 0.80 | 3.48 | 11.23 | 2.14 | 3.23 | 2014- 5- 155-CIN | premium | premium | premium | MLB | 2020-2024 | 2013-2025 | 2021 |
| 68 | Ryan Hendrix | 26 | R | 5 | 1 | 5.97 | 36 | 0 | 0 | 0 | 36 | 9 | 0 | 31.2 | 33 | 23 | 21 | 8 | 16 | 35 | 6 | 0 | 1 | 1.55 | 9.38 | 2.27 | 4.55 | 9.95 | 6.54 | 2.19 | 2016- 5- 138-CIN | premium | premium | premium | MLB | 2021-2022 | 2014-2025 | 2021 |
| 47 | Brad Brach | 35 | R | 1 | 2 | 6.30 | 35 | 0 | 0 | 0 | 35 | 5 | 1 | 30.0 | 30 | 26 | 21 | 5 | 18 | 33 | 2 | 0 | 1 | 1.60 | 9.00 | 1.50 | 5.40 | 9.90 | 7.80 | 1.83 | 2008- 42-1275-SDN | premium | premium | premium | MLB | 2011-2021 | 2005-2022 | 2021 |
| 0 | Alex Blandino | 28 | R | 0 | 0 | 9.82 | 4 | 0 | 0 | 0 | 4 | 2 | 0 | 3.2 | 4 | 5 | 4 | 1 | 4 | 1 | 0 | 0 | 0 | 2.18 | 9.82 | 2.45 | 9.82 | 2.45 | 12.27 | 0.25 | 2014- 1- 29-CIN | premium | premium | premium | MLB | 2018-2021 | 2012-2024 | 2021 |
| 55 | Dauri Moreta | 25 | R | 0 | 0 | 2.45 | 4 | 0 | 0 | 0 | 4 | 3 | 0 | 3.2 | 2 | 1 | 1 | 1 | 1 | 4 | 0 | 0 | 0 | 0.82 | 4.91 | 2.45 | 2.45 | 9.82 | 2.45 | 4.00 | 2015- UDFA -CIN | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 21 | Michael Lorenzen | 29 | R | 1 | 2 | 5.59 | 27 | 0 | 0 | 0 | 27 | 5 | 4 | 29.0 | 26 | 18 | 18 | 2 | 14 | 21 | 5 | 0 | 1 | 1.38 | 8.07 | 0.62 | 4.34 | 6.52 | 5.59 | 1.50 | 2013- 1- 38-CIN | premium | premium | premium | MLB | 2015-2025 | 2011-2025 | 2021 |
| 85 | Luis Cessa | 29 | R | 2 | 1 | 2.05 | 24 | 0 | 0 | 0 | 24 | 2 | 0 | 26.1 | 24 | 7 | 6 | 3 | 2 | 23 | 1 | 0 | 0 | 0.99 | 8.20 | 1.03 | 0.68 | 7.86 | 2.39 | 11.50 | 2008- UDFA -NYN | premium | premium | premium | MLB | 2016-2023 | 2010-2025 | 2021 |
| 41 | Carson Fulmer | 27 | R | 0 | 0 | 6.66 | 20 | 0 | 0 | 0 | 20 | 5 | 0 | 25.2 | 26 | 20 | 19 | 3 | 13 | 24 | 2 | 0 | 3 | 1.52 | 9.12 | 1.05 | 4.56 | 8.42 | 7.01 | 1.85 | 2015- 1- 8-CHA | premium | premium | premium | MLB | 2016-2025 | 2013-2025 | 2021 |
| 43 | Cionel Perez | 25 | L | 1 | 2 | 6.38 | 25 | 0 | 0 | 0 | 25 | 5 | 0 | 24.0 | 21 | 21 | 17 | 5 | 20 | 25 | 1 | 0 | 0 | 1.71 | 7.88 | 1.88 | 7.50 | 9.38 | 7.88 | 1.25 | 2016- UDFA -HOU | premium | premium | premium | MLB | 2018-2025 | 2017-2025 | 2021 |
| 48 | Mychal Givens | 31 | R | 1 | 1 | 4.22 | 23 | 0 | 0 | 0 | 23 | 13 | 8 | 21.1 | 18 | 11 | 10 | 2 | 13 | 20 | 0 | 1 | 0 | 1.45 | 7.59 | 0.84 | 5.48 | 8.44 | 4.64 | 1.54 | 2009- 2- 54-BAL | premium | premium | premium | MLB | 2015-2023 | 2010-2024 | 2021 |
| 77 | Art Warren | 28 | R | 3 | 0 | 1.29 | 26 | 0 | 0 | 0 | 26 | 6 | 0 | 21.0 | 11 | 3 | 3 | 1 | 8 | 34 | 0 | 0 | 1 | 0.90 | 4.71 | 0.43 | 3.43 | 14.57 | 1.29 | 4.25 | 2015- 23- 695-SEA | premium | premium | premium | MLB | 2019-2022 | 2012-2025 | 2021 |
| 48 | Sal Romano | 27 | R | 0 | 0 | 5.23 | 14 | 0 | 0 | 0 | 14 | 5 | 0 | 20.2 | 20 | 14 | 12 | 4 | 9 | 12 | 0 | 1 | 0 | 1.40 | 8.71 | 1.74 | 3.92 | 5.23 | 6.10 | 1.33 | 2011- 23- 715-CIN | premium | premium | premium | MLB | 2017-2021 | 2012-2025 | 2021 |
| 51 | R.J. Alaniz | 30 | R | 0 | 0 | 3.37 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 2.2 | 1 | 1 | 1 | 1 | 3 | 3 | 0 | 0 | 1 | 1.50 | 3.37 | 3.37 | 10.12 | 10.12 | 3.37 | 1.00 | 2009- UDFA -HOU | premium | premium | premium | MLB | 2019-2021 | 2010-2025 | 2021 |
| 58 | Luis Castillo | 28 | R | 8 | 16 | 3.98 | 33 | 33 | 0 | 0 | 0 | 0 | 0 | 187.2 | 181 | 94 | 83 | 19 | 75 | 192 | 1 | 1 | 7 | 1.36 | 8.68 | 0.91 | 3.60 | 9.21 | 4.51 | 2.56 | 2012- UDFA -SFN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 |
| 30 | Tyler Mahle | 26 | R | 13 | 6 | 3.75 | 33 | 33 | 0 | 0 | 0 | 0 | 0 | 180.0 | 158 | 78 | 75 | 24 | 64 | 210 | 4 | 0 | 10 | 1.23 | 7.90 | 1.20 | 3.20 | 10.50 | 3.90 | 3.28 | 2013- 7- 225-CIN | premium | premium | premium | MLB | 2017-2025 | 2013-2025 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 87 | Jose De Leon | 28 | R | 0 | 1 | 8.35 | 9 | 2 | 0 | 0 | 7 | 1 | 0 | 18.1 | 22 | 17 | 17 | 4 | 11 | 33 | 3 | 0 | 2 | 1.80 | 10.80 | 1.96 | 5.40 | 16.20 | 8.35 | 3.00 | 2013- 24- 724-LAN | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 22 | Wade Miley | 34 | L | 12 | 7 | 3.37 | 28 | 28 | 1 | 1 | 0 | 0 | 0 | 163.0 | 166 | 64 | 61 | 17 | 50 | 125 | 2 | 0 | 3 | 1.33 | 9.17 | 0.94 | 2.76 | 6.90 | 3.53 | 2.50 | 2008- 1- 43-ARI | premium | premium | premium | MLB | 2011-2025 | 2006-2025 | 2021 |
| 34 | Justin Wilson | 33 | L | 0 | 0 | 2.81 | 21 | 0 | 0 | 0 | 21 | 6 | 0 | 16.0 | 14 | 5 | 5 | 1 | 7 | 14 | 1 | 0 | 0 | 1.31 | 7.88 | 0.56 | 3.94 | 7.88 | 2.81 | 2.00 | 2008- 5- 144-PIT | premium | premium | premium | MLB | 2012-2025 | 2006-2025 | 2021 |
| 35 | Josh Osich | 32 | L | 2 | 0 | 5.02 | 17 | 0 | 0 | 0 | 17 | 3 | 1 | 14.1 | 15 | 9 | 8 | 4 | 5 | 9 | 0 | 0 | 0 | 1.40 | 9.42 | 2.51 | 3.14 | 5.65 | 5.65 | 1.80 | 2011- 6- 207-SFN | premium | premium | premium | MLB | 2015-2021 | 2008-2021 | 2021 |
| 54 | Sonny Gray | 31 | R | 7 | 9 | 4.19 | 26 | 26 | 0 | 0 | 0 | 0 | 0 | 135.1 | 115 | 67 | 63 | 19 | 50 | 155 | 9 | 0 | 8 | 1.22 | 7.65 | 1.26 | 3.33 | 10.31 | 4.46 | 3.10 | 2011- 1- 18-OAK | premium | premium | premium | MLB | 2013-2025 | 2009-2025 | 2021 |
| 53 | Vladimir Gutierrez | 25 | R | 9 | 6 | 4.74 | 22 | 22 | 0 | 0 | 0 | 0 | 0 | 114.0 | 115 | 61 | 60 | 20 | 46 | 88 | 3 | 2 | 4 | 1.41 | 9.08 | 1.58 | 3.63 | 6.95 | 4.82 | 1.91 | 2016- UDFA -CIN | premium | premium | premium | MLB | 2021-2024 | 2017-2025 | 2021 |
| 52 | Reiver Sanmartin | 25 | L | 2 | 0 | 1.54 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 11.2 | 12 | 2 | 2 | 0 | 2 | 11 | 1 | 1 | 0 | 1.20 | 9.26 | 0.00 | 1.54 | 8.49 | 1.54 | 5.50 | 2015- UDFA -TEX | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 32 | Max Schrock | 26 | R | 0 | 0 | 0.00 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 1.2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 5.40 | 0.00 | 0.00 | 2015- 13- 404-WAS | premium | premium | premium | MLB | 2020-2022 | 2013-2023 | 2021 |
| 57 | Riley O'Brien | 26 | R | 0 | 1 | 13.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1.1 | 2 | 2 | 2 | 2 | 3 | 2 | 0 | 0 | 0 | 3.75 | 13.50 | 13.50 | 20.25 | 13.50 | 13.50 | 0.67 | 2017- 8- 229-TBA | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 27 | Mike Freeman | 33 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0.1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 27.00 | 0.00 | 0.00 | 2010- 11- 331-ARI | premium | premium | premium | MLB | 2016-2021 | 2007-2021 | 2021 |
| Totals: | 83 | 79 | 4.41 | 741 | 162 | 1 | 1 | 161 | 579 | 41 | 1434.1 | 1330 | 760 | 703 | 206 | 617 | 1524 | 62 | 8 | 64 | 1.36 | 8.35 | 1.29 | 3.87 | 9.56 | 4.77 | 2.47 | premium | premium | premium |