| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 9 | Jake Cronenworth | 27 | 2B | L | 108 | 152 | 567 | 94 | 151 | 33 | 7 | 21 | 71 | 4 | 3 | 55 | 90 | 10 | 3 | 3 | 6 | 8 | 261 | 638 | 61 | 90 | .266 | .340 | .460 | .800 | .293 | .194 | .283 | 8.62 | 14.11 | 1.64 | 27.00 | 2015- 7- 208-TBA | premium | premium | premium | MLB | 2020-2025 | 2013-2025 | 2021 |
| 13 | Manny Machado | 28 | 3B | R | 112 | 153 | 564 | 92 | 157 | 31 | 2 | 28 | 106 | 12 | 3 | 63 | 102 | 2 | 0 | 11 | 10 | 10 | 276 | 640 | 61 | 96 | .278 | .347 | .489 | .836 | .339 | .211 | .290 | 9.84 | 15.94 | 1.62 | 20.14 | 2010- 1- 3-BAL | premium | premium | premium | MLB | 2012-2025 | 2010-2025 | 2021 |
| 30 | Eric Hosmer | 31 | 1B | L | 101 | 151 | 509 | 53 | 137 | 28 | 0 | 12 | 65 | 5 | 4 | 48 | 99 | 5 | 1 | 2 | 2 | 13 | 201 | 565 | 40 | 97 | .269 | .337 | .395 | .732 | .222 | .126 | .313 | 8.50 | 17.52 | 2.06 | 42.42 | 2008- 1- 3-KCA | premium | premium | premium | MLB | 2011-2023 | 2008-2023 | 2021 |
| 23 | Fernando Tatis | 22 | SS | R | 130 | 130 | 478 | 99 | 135 | 31 | 0 | 42 | 97 | 25 | 4 | 62 | 153 | 2 | 0 | 4 | 6 | 5 | 292 | 546 | 73 | 62 | .282 | .364 | .611 | .975 | .502 | .329 | .324 | 11.36 | 28.02 | 2.47 | 11.38 | 2015- UDFA -CHA | premium | premium | premium | MLB | 2019-2025 | 2016-2025 | 2021 |
| 28 | Tommy Pham | 33 | LF | R | 101 | 155 | 475 | 74 | 109 | 24 | 2 | 15 | 49 | 14 | 6 | 78 | 128 | 4 | 0 | 4 | 3 | 10 | 182 | 561 | 41 | 68 | .229 | .340 | .383 | .723 | .335 | .154 | .280 | 13.90 | 22.82 | 1.64 | 31.67 | 2006- 16- 496-SLN | premium | premium | premium | MLB | 2014-2025 | 2006-2025 | 2021 |
| 2 | Trent Grisham | 24 | CF | L | 102 | 132 | 462 | 61 | 112 | 28 | 3 | 15 | 62 | 13 | 5 | 54 | 119 | 6 | 1 | 4 | 2 | 10 | 191 | 527 | 46 | 66 | .242 | .327 | .413 | .740 | .305 | .171 | .292 | 10.25 | 22.58 | 2.20 | 30.80 | 2015- 1- 15-MIL | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 |
| 5 | Wil Myers | 30 | RF | R | 105 | 146 | 442 | 56 | 113 | 24 | 2 | 17 | 63 | 8 | 5 | 54 | 141 | 0 | 0 | 4 | 2 | 9 | 192 | 500 | 43 | 70 | .256 | .334 | .434 | .768 | .308 | .178 | .333 | 10.80 | 28.20 | 2.61 | 26.00 | 2009- 3- 91-KCA | premium | premium | premium | MLB | 2013-2023 | 2009-2023 | 2021 |
| 10 | Jurickson Profar | 28 | LF-RF | B | 92 | 137 | 353 | 47 | 80 | 17 | 2 | 4 | 33 | 10 | 5 | 49 | 65 | 6 | 1 | 2 | 1 | 12 | 113 | 411 | 23 | 57 | .227 | .329 | .320 | .649 | .246 | .093 | .266 | 11.92 | 15.82 | 1.33 | 88.25 | 2009- UDFA -TEX | premium | premium | premium | MLB | 2012-2025 | 2010-2025 | 2021 |
| 17 | Victor Caratini | 27 | C | B | 87 | 116 | 313 | 33 | 71 | 9 | 0 | 7 | 39 | 2 | 0 | 35 | 82 | 4 | 0 | 4 | 8 | 13 | 101 | 356 | 16 | 55 | .227 | .309 | .323 | .632 | .214 | .096 | .281 | 9.83 | 23.03 | 2.34 | 44.71 | 2013- 2- 65-ATL | premium | premium | premium | MLB | 2017-2025 | 2013-2025 | 2021 |
| 7 | Ha-Seong Kim | 25 | SS-3B | R | 86 | 117 | 267 | 27 | 54 | 12 | 2 | 8 | 34 | 6 | 1 | 22 | 71 | 4 | 2 | 3 | 1 | 6 | 94 | 298 | 22 | 32 | .202 | .270 | .352 | .622 | .251 | .150 | .241 | 7.38 | 23.83 | 3.23 | 33.38 | 2020- UDFA -SDN | premium | premium | premium | MLB | 2021-2025 | 2021-2025 | 2021 |
| 26 | Adam Frazier | 29 | 2B | L | 108 | 57 | 191 | 25 | 51 | 8 | 1 | 1 | 11 | 5 | 1 | 13 | 23 | 4 | 3 | 0 | 1 | 4 | 64 | 211 | 10 | 41 | .267 | .327 | .335 | .662 | .157 | .068 | .299 | 6.16 | 10.90 | 1.77 | 191.00 | 2013- 6- 179-PIT | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 26 | Austin Nola | 31 | C | R | 99* | 56 | 173 | 15 | 47 | 12 | 0 | 2 | 29 | 0 | 1 | 14 | 19 | 5 | 0 | 2 | 0 | 2 | 65 | 194 | 14 | 33 | .272 | .340 | .376 | .716 | .179 | .104 | .292 | 7.22 | 9.79 | 1.36 | 86.50 | 2012- 5- 167-MIA | premium | premium | premium | MLB | 2019-2025 | 2009-2025 | 2021 |
| 26 | Jorge Mateo | 26 | CF-3B | R | 93 | 57 | 87 | 10 | 18 | 4 | 0 | 2 | 6 | 5 | 0 | 2 | 27 | 3 | 1 | 0 | 0 | 1 | 28 | 93 | 6 | 12 | .207 | .250 | .322 | .572 | .195 | .115 | .276 | 2.15 | 29.03 | 13.50 | 43.50 | 2012- UDFA -NYA | premium | premium | premium | MLB | 2020-2025 | 2012-2025 | 2021 |
| 48 | Webster Rivas | 30 | C | R | 24 | 68 | 8 | 15 | 2 | 0 | 2 | 4 | 0 | 0 | 8 | 16 | 0 | 1 | 0 | 0 | 6 | 23 | 77 | 4 | 11 | .221 | .303 | .338 | .641 | .235 | .117 | .260 | 10.39 | 20.78 | 2.00 | 34.00 | 2009- UDFA -LAN | premium | premium | premium | MLB | 2021-2021 | 2010-2025 | 2021 | |
| 11 | Yu Darvish | 34 | P | R | 29 | 53 | 2 | 5 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 25 | 1 | 1 | 0 | 0 | 2 | 7 | 55 | 2 | 3 | .094 | .111 | .132 | .243 | .038 | .038 | .179 | 0.00 | 45.45 | 0.00 | 0.00 | 2012- UDFA -TEX | premium | premium | premium | MLB | 2012-2025 | 2005-2025 | 2021 | |
| 44 | Joe Musgrove | 28 | P | R | 36 | 51 | 2 | 7 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 23 | 0 | 4 | 1 | 0 | 0 | 9 | 57 | 2 | 5 | .137 | .151 | .176 | .327 | .059 | .039 | .241 | 1.75 | 40.35 | 23.00 | 0.00 | 2011- 1- 46-TOR | premium | premium | premium | MLB | 2016-2024 | 2011-2024 | 2021 | |
| 24 | Brian O'Grady | 29 | RF | L | 32 | 51 | 8 | 8 | 3 | 0 | 2 | 9 | 0 | 0 | 8 | 17 | 0 | 1 | 1 | 0 | 1 | 17 | 61 | 5 | 3 | .157 | .267 | .333 | .600 | .333 | .176 | .182 | 13.11 | 27.87 | 2.13 | 25.50 | 2014- 8- 245-CIN | premium | premium | premium | MLB | 2019-2021 | 2011-2025 | 2021 | |
| 6 | Jake Marisnick | 30 | LF | R | 92 | 34 | 48 | 4 | 9 | 1 | 0 | 0 | 2 | 1 | 0 | 2 | 22 | 3 | 1 | 0 | 0 | 2 | 10 | 54 | 1 | 8 | .188 | .264 | .208 | .472 | .083 | .020 | .346 | 3.70 | 40.74 | 11.00 | 0.00 | 2009- 3- 104-TOR | premium | premium | premium | MLB | 2013-2023 | 2010-2025 | 2021 |
| 16 | Tucupita Marcano | 21 | 2B-RF | L | 25 | 44 | 7 | 8 | 1 | 0 | 0 | 3 | 0 | 1 | 6 | 9 | 0 | 0 | 0 | 0 | 2 | 9 | 50 | 1 | 7 | .182 | .280 | .205 | .485 | .136 | .023 | .229 | 12.00 | 18.00 | 1.50 | 0.00 | 2016- UDFA -SDN | premium | premium | premium | MLB | 2021-2023 | 2017-2023 | 2021 | |
| 59 | Chris Paddack | 25 | P | R | 23 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 26 | 1 | 5 | 0 | 0 | 0 | 1 | 42 | 0 | 1 | .029 | .081 | .029 | .110 | .029 | .000 | .111 | 2.38 | 61.90 | 26.00 | 0.00 | 2015- 8- 236-MIA | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 | |
| 21 | Luis Campusano | 22 | C | R | 11 | 34 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 11 | 0 | 0 | 0 | 0 | 2 | 3 | 38 | 0 | 3 | .088 | .184 | .088 | .272 | .118 | .000 | .130 | 10.53 | 28.95 | 2.75 | 0.00 | 2017- 2- 39-SDN | premium | premium | premium | MLB | 2020-2025 | 2017-2025 | 2021 | |
| 4 | Blake Snell | 28 | P | L | 25 | 34 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 0 | 3 | 0 | 0 | 1 | 4 | 37 | 0 | 4 | .118 | .118 | .118 | .236 | .000 | .000 | .235 | 0.00 | 45.95 | 0.00 | 0.00 | 2011- 1- 52-TBA | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 | |
| 40 | Ryan Weathers | 21 | P | R | 30 | 27 | 3 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 7 | 28 | 1 | 3 | .148 | .179 | .259 | .438 | .148 | .111 | .158 | 3.57 | 25.00 | 7.00 | 27.00 | 2018- 1- 7-SDN | premium | premium | premium | MLB | 2021-2025 | 2018-2025 | 2021 | |
| 74 | Nabil Crismatt | 26 | P | R | 43 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 54.55 | 0.00 | 0.00 | 2012- UDFA -NYN | premium | premium | premium | MLB | 2020-2025 | 2012-2025 | 2021 | |
| 73 | Reiss Knehr | 24 | P | L | 12 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 0 | 8 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 62.50 | 0.00 | 0.00 | 2018- 20- 591-SDN | premium | premium | premium | MLB | 2021-2023 | 2016-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 22 | John Andreoli | 31 | LF-RF | R | 7 | 6 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 1 | 0 | .167 | .286 | .333 | .619 | .333 | .166 | .333 | 14.29 | 42.86 | 3.00 | 0.00 | 2011- 17- 519-CHN | premium | premium | premium | MLB | 2018-2021 | 2009-2022 | 2021 | |
| 29 | Dinelson Lamet | 28 | P | R | 21 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .143 | .000 | .143 | .167 | .000 | .000 | 14.29 | 85.71 | 6.00 | 0.00 | 2014- UDFA -SDN | premium | premium | premium | MLB | 2017-2024 | 2014-2025 | 2021 | |
| 34 | Craig Stammen | 37 | P | R | 64 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 7 | 0 | 1 | .200 | .200 | .200 | .400 | .000 | .000 | .500 | 0.00 | 42.86 | 0.00 | 0.00 | 2005- 12- 354-WAS | premium | premium | premium | MLB | 2009-2022 | 2003-2022 | 2021 | |
| 18 | Patrick Kivlehan | 31 | RF | R | 5 | 4 | 3 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 8 | 0 | 1 | .250 | .500 | .250 | .750 | .500 | .000 | .500 | 25.00 | 37.50 | 1.50 | 0.00 | 2012- 4- 131-SEA | premium | premium | premium | MLB | 2016-2021 | 2012-2023 | 2021 | |
| 72 | Daniel Camarena | 28 | P | L | 6 | 3 | 1 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 1 | 0 | .333 | .333 | 1.333 | 1.666 | 1.000 | 1.000 | .000 | 0.00 | 66.67 | 0.00 | 3.00 | 2011- 20- 629-NYA | premium | premium | premium | MLB | 2021-2021 | 2012-2025 | 2021 | |
| 47 | Nick Ramirez | 31 | P | L | 12 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 33.33 | 0.00 | 0.00 | 2011- 4- 131-MIL | premium | premium | premium | MLB | 2019-2024 | 2009-2025 | 2021 | |
| 37 | Miguel Diaz | 26 | P | R | 23 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 33.33 | 0.00 | 0.00 | 2011- UDFA -MIL | premium | premium | premium | MLB | 2017-2024 | 2012-2025 | 2021 | |
| 61 | Ivan Castillo | 26 | 3B-2B | B | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 1 | .333 | .500 | .333 | .833 | .333 | .000 | .333 | 25.00 | 0.00 | 0.00 | 0.00 | 2011- UDFA -CLE | premium | premium | premium | MLB | 2021-2021 | 2012-2025 | 2021 | |
| 14 | Emilio Pagan | 30 | P | L | 64 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2013- 10- 297-SEA | premium | premium | premium | MLB | 2017-2025 | 2010-2025 | 2021 | |
| 49 | Jake Arrieta | 35 | P | R | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 0 | 1 | .500 | .500 | .500 | 1.000 | .000 | .000 | .500 | 0.00 | 0.00 | 0.00 | 0.00 | 2007- 5- 159-BAL | premium | premium | premium | MLB | 2010-2021 | 2006-2021 | 2021 | |
| 60 | Pedro Avila | 24 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2014- UDFA -WAS | premium | premium | premium | MLB | 2019-2024 | 2015-2025 | 2021 | |
| 50 | Adrian Morejon | 22 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2016- UDFA -SDN | premium | premium | premium | MLB | 2019-2025 | 2017-2025 | 2021 | |
| 38 | Vince Velasquez | 29 | P | R | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .500 | .000 | .500 | 1.000 | .000 | .000 | 25.00 | 0.00 | 0.00 | 0.00 | 2010- 2- 58-HOU | premium | premium | premium | MLB | 2015-2023 | 2010-2025 | 2021 | |
| 33 | Mark Melancon | 36 | P | R | 59 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2006- 9- 284-NYA | premium | premium | premium | MLB | 2009-2022 | 2004-2023 | 2021 | |
| Totals: | 2162 | 5384 | 729 | 1305 | 273 | 21 | 180 | 695 | 110 | 39 | 586 | 1324 | 61 | 36 | 46 | 42 | 121 | 2160 | 6113 | 474 | 831 | .242 | .321 | .401 | .722 | .281 | .159 | .287 | 9.59 | 21.66 | 2.26 | 29.91 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 40 | Ryan Weathers | 21 | L | 4 | 7 | 5.32 | 30 | 18 | 0 | 0 | 12 | 1 | 1 | 94.2 | 101 | 57 | 56 | 20 | 30 | 72 | 2 | 1 | 3 | 1.38 | 9.60 | 1.90 | 2.85 | 6.85 | 5.42 | 2.40 | 2018- 1- 7-SDN | premium | premium | premium | MLB | 2021-2025 | 2018-2025 | 2021 |
| 72 | Daniel Camarena | 28 | L | 0 | 1 | 9.64 | 6 | 0 | 0 | 0 | 6 | 2 | 0 | 9.1 | 16 | 12 | 10 | 2 | 3 | 7 | 0 | 0 | 0 | 2.04 | 15.43 | 1.93 | 2.89 | 6.75 | 11.57 | 2.33 | 2011- 20- 629-NYA | premium | premium | premium | MLB | 2021-2021 | 2012-2025 | 2021 |
| 34 | Craig Stammen | 37 | R | 6 | 3 | 3.06 | 67 | 4 | 0 | 0 | 63 | 4 | 1 | 88.1 | 79 | 31 | 30 | 13 | 13 | 83 | 3 | 0 | 3 | 1.04 | 8.05 | 1.32 | 1.32 | 8.46 | 3.16 | 6.38 | 2005- 12- 354-WAS | premium | premium | premium | MLB | 2009-2022 | 2003-2022 | 2021 |
| 74 | Nabil Crismatt | 26 | R | 3 | 1 | 3.76 | 45 | 0 | 0 | 0 | 45 | 14 | 0 | 81.1 | 87 | 40 | 34 | 10 | 24 | 71 | 3 | 0 | 8 | 1.36 | 9.63 | 1.11 | 2.66 | 7.86 | 4.43 | 2.96 | 2012- UDFA -NYN | premium | premium | premium | MLB | 2020-2025 | 2012-2025 | 2021 |
| 43 | Aaron Northcraft | 31 | R | 1 | 0 | 2.25 | 5 | 0 | 0 | 0 | 5 | 3 | 0 | 8.0 | 5 | 2 | 2 | 1 | 8 | 5 | 0 | 0 | 0 | 1.63 | 5.63 | 1.13 | 9.00 | 5.63 | 2.25 | 0.63 | 2009- 10- 298-ATL | premium | premium | premium | MLB | 2021-2021 | 2009-2022 | 2021 |
| 45 | Ross Detwiler | 35 | L | 1 | 0 | 2.57 | 7 | 0 | 0 | 0 | 7 | 4 | 0 | 7.0 | 3 | 2 | 2 | 2 | 5 | 6 | 1 | 0 | 1 | 1.14 | 3.86 | 2.57 | 6.43 | 7.71 | 2.57 | 1.20 | 2007- 1- 6-WAS | premium | premium | premium | MLB | 2007-2022 | 2005-2022 | 2021 |
| 33 | Mark Melancon | 36 | R | 4 | 3 | 2.23 | 64 | 0 | 0 | 0 | 64 | 53 | 39 | 64.2 | 54 | 21 | 16 | 4 | 25 | 59 | 3 | 0 | 1 | 1.22 | 7.52 | 0.56 | 3.48 | 8.21 | 2.92 | 2.36 | 2006- 9- 284-NYA | premium | premium | premium | MLB | 2009-2022 | 2004-2023 | 2021 |
| 14 | Emilio Pagan | 30 | R | 4 | 3 | 4.83 | 67 | 0 | 0 | 0 | 67 | 10 | 0 | 63.1 | 56 | 35 | 34 | 16 | 18 | 69 | 0 | 0 | 2 | 1.17 | 7.96 | 2.27 | 2.56 | 9.81 | 4.97 | 3.83 | 2013- 10- 297-SEA | premium | premium | premium | MLB | 2017-2025 | 2010-2025 | 2021 |
| 55 | Matt Strahm | 29 | L | 0 | 1 | 8.10 | 6 | 1 | 0 | 0 | 5 | 0 | 0 | 6.2 | 15 | 6 | 6 | 0 | 1 | 4 | 0 | 0 | 0 | 2.40 | 20.25 | 0.00 | 1.35 | 5.40 | 8.10 | 4.00 | 2012- 21- 643-KCA | premium | premium | premium | MLB | 2016-2025 | 2012-2025 | 2021 |
| 25 | Tim Hill | 31 | L | 6 | 6 | 3.62 | 78 | 0 | 0 | 0 | 78 | 10 | 1 | 59.2 | 51 | 34 | 24 | 9 | 23 | 56 | 1 | 0 | 6 | 1.24 | 7.69 | 1.36 | 3.47 | 8.45 | 5.13 | 2.43 | 2014- 32- 963-KCA | premium | premium | premium | MLB | 2018-2025 | 2013-2025 | 2021 |
| 36 | Pierce Johnson | 30 | R | 3 | 4 | 3.22 | 63 | 2 | 0 | 0 | 61 | 7 | 0 | 58.2 | 47 | 21 | 21 | 6 | 27 | 77 | 6 | 0 | 1 | 1.26 | 7.21 | 0.92 | 4.14 | 11.81 | 3.22 | 2.85 | 2012- 1- 43-CHN | premium | premium | premium | MLB | 2017-2025 | 2010-2025 | 2021 |
| 54 | Austin Adams | 30 | R | 3 | 2 | 4.10 | 65 | 0 | 0 | 0 | 65 | 18 | 0 | 52.2 | 28 | 28 | 24 | 1 | 35 | 76 | 4 | 0 | 24 | 1.20 | 4.78 | 0.17 | 5.98 | 12.99 | 4.78 | 2.17 | 2012- 8- 267-ANA | premium | premium | premium | MLB | 2017-2024 | 2010-2025 | 2021 |
| 45 | Taylor Williams | 29 | R | 0 | 0 | 1.69 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 5.1 | 3 | 1 | 1 | 0 | 3 | 6 | 0 | 0 | 2 | 1.13 | 5.06 | 0.00 | 5.06 | 10.13 | 1.69 | 2.00 | 2013- 4- 122-MIL | premium | premium | premium | MLB | 2017-2021 | 2011-2025 | 2021 |
| 67 | James Norwood | 27 | R | 0 | 0 | 0.00 | 5 | 0 | 0 | 0 | 5 | 2 | 0 | 5.0 | 6 | 0 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 1.80 | 10.80 | 0.00 | 5.40 | 5.40 | 0.00 | 1.00 | 2014- 7- 199-CHN | premium | premium | premium | MLB | 2018-2022 | 2012-2023 | 2021 |
| 29 | Dinelson Lamet | 28 | R | 2 | 4 | 4.40 | 22 | 9 | 0 | 0 | 13 | 1 | 0 | 47.0 | 48 | 24 | 23 | 6 | 22 | 57 | 3 | 0 | 2 | 1.49 | 9.19 | 1.15 | 4.21 | 10.91 | 4.60 | 2.59 | 2014- UDFA -SDN | premium | premium | premium | MLB | 2017-2024 | 2014-2025 | 2021 |
| 37 | Miguel Diaz | 26 | R | 3 | 1 | 3.64 | 25 | 2 | 0 | 0 | 23 | 10 | 1 | 42.0 | 31 | 19 | 17 | 8 | 19 | 46 | 0 | 0 | 0 | 1.19 | 6.64 | 1.71 | 4.07 | 9.86 | 4.07 | 2.42 | 2011- UDFA -MIL | premium | premium | premium | MLB | 2017-2024 | 2012-2025 | 2021 |
| 64 | Shaun Anderson | 26 | R | 0 | 0 | 5.79 | 5 | 0 | 0 | 0 | 5 | 1 | 0 | 4.2 | 6 | 3 | 3 | 0 | 2 | 4 | 0 | 0 | 0 | 1.71 | 11.57 | 0.00 | 3.86 | 7.71 | 5.79 | 2.00 | 2016- 3- 88-BOS | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 50 | Adrian Morejon | 22 | L | 0 | 0 | 3.86 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 4.2 | 5 | 2 | 2 | 2 | 2 | 3 | 0 | 0 | 0 | 1.50 | 9.64 | 3.86 | 3.86 | 5.79 | 3.86 | 1.50 | 2016- UDFA -SDN | premium | premium | premium | MLB | 2019-2025 | 2017-2025 | 2021 |
| 60 | Pedro Avila | 24 | R | 0 | 1 | 2.25 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.0 | 4 | 2 | 1 | 1 | 3 | 5 | 0 | 0 | 0 | 1.75 | 9.00 | 2.25 | 6.75 | 11.25 | 4.50 | 1.67 | 2014- UDFA -WAS | premium | premium | premium | MLB | 2019-2024 | 2015-2025 | 2021 |
| 8 | Javy Guerra | 25 | R | 0 | 0 | 4.91 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 3.2 | 4 | 2 | 2 | 0 | 2 | 3 | 0 | 0 | 0 | 1.64 | 9.82 | 0.00 | 4.91 | 7.36 | 4.91 | 1.50 | 2012- UDFA -BOS | premium | premium | premium | MLB | 2018-2023 | 2013-2025 | 2021 |
| 71 | Mason Thompson | 23 | R | 0 | 0 | 3.00 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 3.0 | 4 | 1 | 1 | 0 | 1 | 2 | 2 | 0 | 0 | 1.67 | 12.00 | 0.00 | 3.00 | 6.00 | 3.00 | 2.00 | 2016- 3- 85-SDN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 73 | Reiss Knehr | 24 | R | 1 | 2 | 4.97 | 12 | 5 | 0 | 0 | 7 | 1 | 0 | 29.0 | 23 | 16 | 16 | 2 | 20 | 20 | 3 | 0 | 2 | 1.48 | 7.14 | 0.62 | 6.21 | 6.21 | 4.97 | 1.00 | 2018- 20- 591-SDN | premium | premium | premium | MLB | 2021-2023 | 2016-2025 | 2021 |
| 15 | Drew Pomeranz | 32 | L | 1 | 0 | 1.75 | 27 | 0 | 0 | 0 | 27 | 2 | 0 | 25.2 | 19 | 6 | 5 | 2 | 10 | 30 | 1 | 0 | 0 | 1.13 | 6.66 | 0.70 | 3.51 | 10.52 | 2.10 | 3.00 | 2010- 1- 5-CLE | premium | premium | premium | MLB | 2011-2025 | 2008-2025 | 2021 |
| 47 | Nick Ramirez | 31 | L | 1 | 1 | 5.75 | 13 | 0 | 0 | 0 | 13 | 5 | 0 | 20.1 | 23 | 15 | 13 | 2 | 7 | 14 | 0 | 0 | 0 | 1.48 | 10.18 | 0.89 | 3.10 | 6.20 | 6.64 | 2.00 | 2011- 4- 131-MIL | premium | premium | premium | MLB | 2019-2024 | 2009-2025 | 2021 |
| 18 | Daniel Hudson | 34 | R | 1 | 2 | 5.21 | 23 | 0 | 0 | 0 | 23 | 6 | 0 | 19.0 | 17 | 13 | 11 | 4 | 9 | 27 | 2 | 0 | 0 | 1.37 | 8.05 | 1.89 | 4.26 | 12.79 | 6.16 | 3.00 | 2008- 5- 150-CHA | premium | premium | premium | MLB | 2009-2024 | 2006-2024 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 44 | Joe Musgrove | 28 | R | 11 | 9 | 3.18 | 32 | 31 | 2 | 2 | 1 | 1 | 0 | 181.1 | 142 | 68 | 64 | 22 | 54 | 203 | 3 | 0 | 18 | 1.08 | 7.05 | 1.09 | 2.68 | 10.08 | 3.38 | 3.76 | 2011- 1- 46-TOR | premium | premium | premium | MLB | 2016-2024 | 2011-2024 | 2021 |
| 11 | Yu Darvish | 34 | R | 8 | 11 | 4.22 | 30 | 30 | 0 | 0 | 0 | 0 | 0 | 166.1 | 138 | 81 | 78 | 28 | 44 | 199 | 9 | 0 | 8 | 1.09 | 7.47 | 1.52 | 2.38 | 10.77 | 4.38 | 4.52 | 2012- UDFA -TEX | premium | premium | premium | MLB | 2012-2025 | 2005-2025 | 2021 |
| 4 | Blake Snell | 28 | L | 7 | 6 | 4.20 | 27 | 27 | 0 | 0 | 0 | 0 | 0 | 128.2 | 101 | 61 | 60 | 16 | 69 | 170 | 7 | 1 | 3 | 1.32 | 7.06 | 1.12 | 4.83 | 11.89 | 4.27 | 2.46 | 2011- 1- 52-TBA | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 38 | Vince Velasquez | 29 | R | 0 | 3 | 8.53 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 12.2 | 15 | 13 | 12 | 6 | 4 | 16 | 0 | 0 | 0 | 1.50 | 10.66 | 4.26 | 2.84 | 11.37 | 9.24 | 4.00 | 2010- 2- 58-HOU | premium | premium | premium | MLB | 2015-2023 | 2010-2025 | 2021 |
| 49 | Jake Arrieta | 35 | R | 0 | 3 | 10.95 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 12.1 | 18 | 16 | 15 | 3 | 5 | 9 | 0 | 0 | 2 | 1.86 | 13.14 | 2.19 | 3.65 | 6.57 | 11.68 | 1.80 | 2007- 5- 159-BAL | premium | premium | premium | MLB | 2010-2021 | 2006-2021 | 2021 |
| 59 | Chris Paddack | 25 | R | 7 | 7 | 5.07 | 23 | 22 | 0 | 0 | 1 | 0 | 0 | 108.1 | 115 | 67 | 61 | 15 | 22 | 99 | 2 | 0 | 1 | 1.26 | 9.55 | 1.25 | 1.83 | 8.22 | 5.57 | 4.50 | 2015- 8- 236-MIA | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 |
| 27 | Keone Kela | 28 | R | 2 | 2 | 5.06 | 12 | 0 | 0 | 0 | 12 | 2 | 0 | 10.2 | 11 | 8 | 6 | 3 | 3 | 13 | 2 | 0 | 0 | 1.31 | 9.28 | 2.53 | 2.53 | 10.97 | 6.75 | 4.33 | 2012- 12- 396-TEX | premium | premium | premium | MLB | 2015-2021 | 2012-2025 | 2021 |
| 57 | Dan Altavilla | 28 | R | 0 | 0 | 6.75 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 1.1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0.75 | 6.75 | 6.75 | 0.00 | 13.50 | 6.75 | 0.00 | 2014- 5- 141-SEA | premium | premium | premium | MLB | 2016-2025 | 2012-2025 | 2021 |
| 9 | Jake Cronenworth | 27 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1.50 | 13.50 | 0.00 | 0.00 | 13.50 | 0.00 | 0.00 | 2015- 7- 208-TBA | premium | premium | premium | MLB | 2020-2025 | 2013-2025 | 2021 |
| Totals: | 79 | 83 | 4.10 | 786 | 162 | 2 | 2 | 160 | 624 | 43 | 1430.0 | 1277 | 708 | 651 | 205 | 516 | 1517 | 57 | 2 | 87 | 1.25 | 8.04 | 1.29 | 3.25 | 9.55 | 4.46 | 2.94 | premium | premium | premium |