| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 28 | Junior Sanquintin | 19 | 1B | B | 100 | 47 | 176 | 35 | 44 | 11 | 1 | 8 | 36 | 4 | 0 | 14 | 59 | 2 | 0 | 3 | 0 | 4 | 81 | 195 | 20 | 24 | .250 | .308 | .460 | .768 | .313 | .210 | .321 | 7.18 | 30.26 | 4.21 | 22.00 | 2018- UDFA -CLE | premium | premium | premium | A+ | 2019-2023 | 2021 | |
| 23 | Luis Durango | 18 | CF | L | 112 | 46 | 156 | 37 | 48 | 6 | 0 | 3 | 20 | 28 | 7 | 18 | 31 | 7 | 1 | 2 | 0 | 5 | 63 | 184 | 9 | 39 | .308 | .399 | .404 | .803 | .346 | .096 | .363 | 9.78 | 16.85 | 1.72 | 52.00 | 2019- UDFA -CLE | premium | premium | premium | A+ | 2021-2025 | 2021 | |
| 10 | Dayan Frias | 19 | SS-3B | B | 119 | 42 | 152 | 32 | 49 | 12 | 3 | 4 | 24 | 3 | 2 | 27 | 38 | 3 | 0 | 6 | 2 | 1 | 79 | 188 | 19 | 30 | .322 | .420 | .520 | .940 | .382 | .198 | .388 | 14.36 | 20.21 | 1.41 | 38.00 | 2018- UDFA -CLE | premium | premium | premium | AAA | 2019-2025 | 2021 | |
| 13 | Isaiah Greene | 19 | CF-LF | L | 106 | 43 | 152 | 31 | 44 | 9 | 0 | 1 | 16 | 5 | 4 | 35 | 42 | 1 | 1 | 2 | 1 | 1 | 56 | 191 | 10 | 34 | .289 | .421 | .368 | .789 | .316 | .079 | .387 | 18.32 | 21.99 | 1.20 | 152.00 | 2020- 2- 69-NYN | premium | premium | premium | A+ | 2021-2024 | 2021 | |
| 16 | Jose Devers | 18 | 3B-2B | R | 84 | 43 | 146 | 24 | 31 | 3 | 0 | 3 | 23 | 6 | 3 | 20 | 49 | 2 | 0 | 2 | 0 | 2 | 43 | 170 | 6 | 25 | .212 | .312 | .295 | .607 | .240 | .083 | .292 | 11.76 | 28.82 | 2.45 | 48.67 | 2019- UDFA -CLE | premium | premium | premium | A+ | 2021-2025 | 2021 | |
| 4 | Milan Tolentino | 19 | SS-3B | L | 112 | 32 | 123 | 27 | 37 | 4 | 1 | 6 | 31 | 3 | 1 | 10 | 40 | 3 | 0 | 2 | 0 | 0 | 61 | 138 | 11 | 26 | .301 | .362 | .496 | .858 | .293 | .195 | .392 | 7.25 | 28.99 | 4.00 | 20.50 | 2020- 4- 124-CLE | premium | premium | premium | AAA | 2021-2025 | 2021 | |
| 9 | Skeiling Rodriguez | 20 | RF-LF | L | 111 | 34 | 117 | 25 | 34 | 7 | 2 | 5 | 24 | 1 | 2 | 11 | 27 | 1 | 0 | 0 | 0 | 1 | 60 | 129 | 14 | 20 | .291 | .357 | .513 | .870 | .308 | .222 | .341 | 8.53 | 20.93 | 2.45 | 23.40 | 2017- UDFA -CLE | premium | premium | premium | A | 2018-2022 | 2021 | |
| 27 | Jose Pastrano | 18 | 2B | B | 93 | 32 | 102 | 19 | 23 | 8 | 2 | 0 | 14 | 2 | 2 | 20 | 28 | 1 | 0 | 1 | 1 | 3 | 35 | 124 | 10 | 13 | .225 | .355 | .343 | .698 | .314 | .118 | .307 | 16.13 | 22.58 | 1.40 | 0.00 | 2019- UDFA -CLE | premium | premium | premium | A | 2021-2024 | 2021 | |
| 48 | Jorge Burgos | 18 | RF-LF | L | 124 | 31 | 102 | 25 | 36 | 11 | 0 | 0 | 14 | 4 | 1 | 18 | 26 | 3 | 0 | 0 | 0 | 0 | 47 | 123 | 11 | 25 | .353 | .463 | .461 | .924 | .314 | .108 | .474 | 14.63 | 21.14 | 1.44 | 0.00 | 2019- UDFA -CLE | premium | premium | premium | AA | 2019-2025 | 2021 | |
| 24 | Jordan Brown | 19 | LF | R | 69 | 26 | 91 | 10 | 14 | 3 | 0 | 2 | 13 | 0 | 2 | 11 | 38 | 2 | 0 | 1 | 0 | 1 | 23 | 105 | 5 | 9 | .154 | .257 | .253 | .510 | .198 | .099 | .231 | 10.48 | 36.19 | 3.45 | 45.50 | 2019- 6- 190-CLE | premium | premium | premium | A | 2019-2023 | 2021 | |
| 70 | Richard Paz | 20 | C | L | 136 | 26 | 89 | 18 | 32 | 5 | 1 | 6 | 25 | 0 | 0 | 11 | 16 | 6 | 0 | 4 | 0 | 0 | 57 | 110 | 12 | 20 | .360 | .445 | .640 | 1.085 | .404 | .280 | .366 | 10.00 | 14.55 | 1.45 | 14.83 | 2018- UDFA -CLE | premium | premium | premium | A+ | 2018-2024 | 2021 | |
| 35 | Victor Planchart | 20 | C | B | 116 | 28 | 87 | 18 | 24 | 9 | 1 | 3 | 16 | 0 | 0 | 14 | 16 | 3 | 0 | 1 | 0 | 0 | 44 | 105 | 13 | 11 | .276 | .390 | .506 | .896 | .391 | .230 | .304 | 13.33 | 15.24 | 1.14 | 29.00 | 2017- UDFA -CLE | premium | premium | premium | A+ | 2018-2023 | 2021 | |
| 41 | Micael Ramirez | 22 | C-1B | R | 146 | 17 | 56 | 15 | 24 | 11 | 0 | 0 | 13 | 1 | 1 | 11 | 2 | 2 | 1 | 1 | 0 | 1 | 35 | 71 | 11 | 13 | .429 | .529 | .625 | 1.154 | .393 | .196 | .436 | 15.49 | 2.82 | 0.18 | 0.00 | 2017- UDFA -CLE | premium | premium | premium | AAA | 2017-2024 | 2021 | |
| 32 | Jesus Lara | 19 | 2B | R | 93 | 19 | 52 | 11 | 9 | 2 | 0 | 2 | 8 | 0 | 1 | 11 | 15 | 3 | 0 | 0 | 0 | 0 | 17 | 66 | 4 | 5 | .173 | .348 | .327 | .675 | .346 | .154 | .200 | 16.67 | 22.73 | 1.36 | 26.00 | 2018- UDFA -CLE | premium | premium | premium | Rk | 2019-2021 | 2021 | |
| 11 | Michael Cooper | 21 | 1B | L | 79* | 15 | 47 | 8 | 9 | 3 | 0 | 1 | 8 | 0 | 1 | 6 | 10 | 1 | 0 | 2 | 0 | 0 | 15 | 56 | 4 | 5 | .191 | .286 | .319 | .605 | .234 | .128 | .211 | 10.71 | 17.86 | 1.67 | 47.00 | 2017- 33-1002-CLE | premium | premium | premium | A- | 2017-2021 | 2021 | |
| 41 | Connor Kokx | 21 | CF-RF | R | 116* | 15 | 42 | 9 | 10 | 1 | 1 | 1 | 4 | 5 | 1 | 6 | 11 | 8 | 0 | 0 | 0 | 0 | 16 | 56 | 3 | 7 | .238 | .429 | .381 | .810 | .381 | .143 | .300 | 10.71 | 19.64 | 1.83 | 42.00 | 2021- 12- 366-CLE | premium | premium | premium | AA | 2019-2024 | 2021 | |
| 60 | Jake Fox | 18 | 2B-SS | L | 128* | 13 | 42 | 10 | 17 | 1 | 0 | 0 | 6 | 7 | 0 | 6 | 9 | 0 | 0 | 1 | 0 | 0 | 18 | 49 | 1 | 16 | .405 | .469 | .429 | .898 | .333 | .024 | .500 | 12.24 | 18.37 | 1.50 | 0.00 | 2021- 3- 95-CLE | premium | premium | premium | AA | 2021-2025 | 2021 | |
| 54 | Julian Escobedo | 23 | CF | L | 119* | 8 | 30 | 5 | 9 | 1 | 0 | 2 | 9 | 2 | 1 | 4 | 8 | 0 | 0 | 0 | 0 | 1 | 16 | 34 | 3 | 6 | .300 | .382 | .533 | .915 | .400 | .233 | .350 | 11.76 | 23.53 | 2.00 | 15.00 | 2019- 17- 520-CLE | premium | premium | premium | AA | 2017-2025 | 2021 | |
| 33 | Sterling Romero | 19 | RF-LF | L | 10 | 27 | 3 | 7 | 2 | 1 | 1 | 4 | 0 | 0 | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 14 | 29 | 4 | 3 | .259 | .310 | .519 | .829 | .333 | .260 | .333 | 6.90 | 27.59 | 4.00 | 27.00 | 2018- UDFA -CLE | premium | premium | premium | Rk | 2019-2022 | 2021 | ||
| 1 | Carson Tucker | 19 | SS | R | 6 | 20 | 6 | 3 | 0 | 0 | 1 | 3 | 1 | 1 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 6 | 25 | 1 | 2 | .150 | .320 | .300 | .620 | .400 | .150 | .133 | 20.00 | 16.00 | 0.80 | 20.00 | 2020- 1- 23-CLE | premium | premium | premium | A | 2021-2025 | 2021 | ||
| 15 | Micah Pries | 23 | 1B-LF | L | 5 | 17 | 4 | 8 | 0 | 1 | 3 | 6 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 19 | 18 | 4 | 4 | .471 | .500 | 1.118 | 1.618 | .706 | .647 | .455 | 5.56 | 16.67 | 3.00 | 5.67 | 2019- 13- 400-CLE | premium | premium | premium | AAA | 2017-2025 | 2021 | ||
| 4 | Will Bartlett | 20 | 1B | R | 5 | 17 | 1 | 4 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 5 | 17 | 1 | 3 | .235 | .235 | .294 | .529 | .059 | .059 | .444 | 0.00 | 47.06 | 0.00 | 0.00 | 2019- 9- 280-CLE | premium | premium | premium | A+ | 2019-2023 | 2021 | ||
| 44 | Jhonkensy Noel | 19 | 3B | R | 6 | 15 | 1 | 3 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 4 | 1 | 0 | 0 | 0 | 0 | 4 | 17 | 1 | 2 | .200 | .294 | .267 | .561 | .067 | .067 | .273 | 5.88 | 23.53 | 4.00 | 0.00 | 2017- UDFA -CLE | premium | premium | premium | MLB | 2024-2025 | 2018-2025 | 2021 | |
| - | Michael Amditis | 23 | C | R | 4 | 12 | 2 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 13 | 0 | 3 | .250 | .308 | .250 | .558 | .083 | .000 | .429 | 7.69 | 38.46 | 5.00 | 0.00 | 2019- 21- 640-CLE | premium | premium | premium | AA | 2017-2023 | 2021 | ||
| 17 | Zac Fascia | 22 | C | L | 1 | 3 | 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 1 | 1.000 | 1.000 | 1.667 | 2.667 | .667 | .667 | 1.000 | 0.00 | 0.00 | 0.00 | 0.00 | 2018- 37-1100-NYN | premium | premium | premium | AAA | 2018-2024 | 2021 | ||
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 17 | Jordan Luplow | 27 | RF-CF | R | 3 | 3 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 | 1 | .333 | .714 | .333 | 1.047 | 1.333 | .000 | .333 | 57.14 | 0.00 | 0.00 | 0.00 | 2014- 3- 100-PIT | premium | premium | premium | MLB | 2017-2023 | 2012-2025 | 2021 | |
| 15 | Seth Caddell | 22 | C | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2021- UDFA -CLE | premium | premium | premium | AAA | 2018-2023 | 2021 | ||
| Totals: | 558 | 1878 | 381 | 526 | 113 | 14 | 52 | 321 | 72 | 31 | 267 | 498 | 49 | 3 | 28 | 4 | 20 | 823 | 2225 | 179 | 347 | .280 | .379 | .438 | .817 | .322 | .158 | .350 | 12.00 | 22.38 | 1.87 | 36.12 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 66 | Will Dion | 21 | L | 0 | 0 | 0.00 | 4 | 3 | 0 | 0 | 1 | 0 | 0 | 9.0 | 1 | 1 | 0 | 0 | 3 | 18 | 0 | 0 | 0 | 0.44 | 1.00 | 0.00 | 3.00 | 18.00 | 1.00 | 6.00 | 2021- 9- 276-CLE | premium | premium | premium | AAA | 2019-2025 | 2021 | |
| 69 | Hugo Villalobos | 19 | R | 2 | 1 | 6.00 | 6 | 0 | 0 | 0 | 6 | 5 | 1 | 9.0 | 10 | 6 | 6 | 1 | 2 | 9 | 1 | 0 | 2 | 1.33 | 10.00 | 1.00 | 2.00 | 9.00 | 6.00 | 4.50 | 2019- UDFA -CLE | premium | premium | premium | A | 2019-2023 | 2021 | |
| 46 | Jhon Vergara | 21 | R | 0 | 0 | 10.80 | 4 | 2 | 0 | 0 | 2 | 0 | 0 | 8.1 | 12 | 11 | 10 | 2 | 4 | 8 | 0 | 0 | 2 | 1.92 | 12.96 | 2.16 | 4.32 | 8.64 | 11.88 | 2.00 | 2017- UDFA -CLE | premium | premium | premium | Rk | 2018-2022 | 2021 | |
| 54 | Aaron Davenport | 20 | R | 1 | 0 | 3.18 | 3 | 2 | 0 | 0 | 1 | 0 | 0 | 5.2 | 3 | 3 | 2 | 2 | 2 | 11 | 2 | 0 | 0 | 0.88 | 4.76 | 3.18 | 3.18 | 17.47 | 4.76 | 5.50 | 2021- 6- 186-CLE | premium | premium | premium | AAA | 2019-2025 | 2021 | |
| 39 | Jacob Forrester | 25 | R | 1 | 1 | 3.38 | 4 | 0 | 0 | 0 | 4 | 3 | 1 | 5.1 | 6 | 2 | 2 | 0 | 4 | 10 | 1 | 0 | 0 | 1.88 | 10.13 | 0.00 | 6.75 | 16.88 | 3.38 | 2.50 | 2019- 37-1120-CLE | premium | premium | premium | A | 2015-2021 | 2021 | |
| 63 | Alaska Abney | 21 | R | 0 | 0 | 0.00 | 4 | 0 | 0 | 0 | 4 | 2 | 1 | 5.0 | 3 | 0 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 1.20 | 5.40 | 0.00 | 5.40 | 10.80 | 0.00 | 2.00 | 2021- 15- 456-CLE | premium | premium | premium | AA | 2019-2025 | 2021 | |
| 59 | Allan Hernandez | 20 | R | 0 | 0 | 7.20 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 5.0 | 5 | 4 | 4 | 3 | 2 | 7 | 1 | 0 | 0 | 1.40 | 9.00 | 5.40 | 3.60 | 12.60 | 7.20 | 3.50 | 2019- 12- 370-CLE | premium | premium | premium | AA | 2019-2025 | 2021 | |
| 44 | Joey Cantillo | 21 | L | 0 | 0 | 0.00 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 5.0 | 2 | 0 | 0 | 0 | 1 | 7 | 1 | 0 | 0 | 0.60 | 3.60 | 0.00 | 1.80 | 12.60 | 0.00 | 7.00 | 2017- 16- 468-SDN | premium | premium | premium | MLB | 2024-2025 | 2017-2025 | 2021 |
| 37 | Cody Morris | 24 | R | 0 | 0 | 2.08 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.1 | 2 | 2 | 1 | 1 | 1 | 12 | 1 | 0 | 0 | 0.69 | 4.15 | 2.08 | 2.08 | 24.92 | 4.15 | 12.00 | 2018- 7- 223-CLE | premium | premium | premium | MLB | 2022-2023 | 2017-2024 | 2021 |
| 43 | Matt Turner | 21 | L | 0 | 0 | 0.00 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 4.0 | 1 | 0 | 0 | 0 | 1 | 8 | 0 | 0 | 0 | 0.50 | 2.25 | 0.00 | 2.25 | 18.00 | 0.00 | 8.00 | 2017- 11- 342-CLE | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 64 | Steven Perez | 20 | L | 2 | 0 | 6.52 | 13 | 6 | 0 | 0 | 7 | 2 | 1 | 38.2 | 39 | 34 | 28 | 7 | 16 | 47 | 3 | 0 | 6 | 1.42 | 9.08 | 1.63 | 3.72 | 10.94 | 7.91 | 2.94 | 2018- UDFA -CLE | premium | premium | premium | AA | 2018-2025 | 2021 | |
| 58 | Tomas Reyes | 21 | L | 3 | 1 | 5.97 | 12 | 4 | 0 | 0 | 8 | 0 | 0 | 37.2 | 40 | 26 | 25 | 3 | 14 | 33 | 3 | 1 | 3 | 1.43 | 9.56 | 0.72 | 3.35 | 7.88 | 6.21 | 2.36 | 2018- UDFA -CLE | premium | premium | premium | A | 2018-2023 | 2021 | |
| 49 | Diarlin Jimenez | 21 | R | 3 | 1 | 6.68 | 17 | 0 | 0 | 0 | 17 | 2 | 0 | 31.0 | 36 | 27 | 23 | 9 | 13 | 28 | 9 | 1 | 3 | 1.58 | 10.45 | 2.61 | 3.77 | 8.13 | 7.84 | 2.15 | 2016- UDFA -CLE | premium | premium | premium | Rk | 2017-2021 | 2021 | |
| 55 | Elmson Candelario | 20 | R | 3 | 2 | 3.77 | 10 | 8 | 0 | 0 | 2 | 1 | 0 | 31.0 | 27 | 20 | 13 | 4 | 15 | 34 | 10 | 0 | 5 | 1.35 | 7.84 | 1.16 | 4.35 | 9.87 | 5.81 | 2.27 | 2019- UDFA -CLE | premium | premium | premium | Rk | 2021-2023 | 2021 | |
| 45 | Alonzo Richardson | 18 | R | 1 | 3 | 8.42 | 12 | 8 | 0 | 0 | 4 | 0 | 0 | 31.0 | 45 | 30 | 29 | 8 | 18 | 35 | 8 | 1 | 3 | 2.03 | 13.06 | 2.32 | 5.23 | 10.16 | 8.71 | 1.94 | premium | premium | premium | AAA | 2021-2025 | 2021 | ||
| 65 | Adrian Rodriguez | 20 | R | 2 | 2 | 7.71 | 19 | 0 | 0 | 0 | 19 | 1 | 0 | 30.1 | 38 | 28 | 26 | 8 | 17 | 30 | 5 | 2 | 2 | 1.81 | 11.27 | 2.37 | 5.04 | 8.90 | 8.31 | 1.76 | 2019- UDFA -CLE | premium | premium | premium | Rk | 2019-2022 | 2021 | |
| 50 | Juan Mateo | 28 | R | 4 | 1 | 5.10 | 22 | 0 | 0 | 0 | 22 | 11 | 0 | 30.0 | 28 | 25 | 17 | 2 | 12 | 27 | 6 | 0 | 6 | 1.33 | 8.40 | 0.60 | 3.60 | 8.10 | 7.50 | 2.25 | 2020- UDFA -CLE | premium | premium | premium | A | 2019-2025 | 2021 | |
| 38 | Daniel Figueroa | 20 | R | 2 | 2 | 3.81 | 20 | 0 | 0 | 0 | 20 | 5 | 1 | 28.1 | 34 | 19 | 12 | 4 | 15 | 35 | 7 | 0 | 3 | 1.73 | 10.80 | 1.27 | 4.76 | 11.12 | 6.04 | 2.33 | 2018- UDFA -CLE | premium | premium | premium | Rk | 2018-2023 | 2021 | |
| 39 | Reny Artiles | 19 | R | 1 | 1 | 4.94 | 9 | 8 | 0 | 0 | 1 | 0 | 0 | 27.1 | 30 | 15 | 15 | 4 | 12 | 43 | 3 | 0 | 0 | 1.54 | 9.88 | 1.32 | 3.95 | 14.16 | 4.94 | 3.58 | 2018- UDFA -CLE | premium | premium | premium | A | 2019-2024 | 2021 | |
| 51 | Samuel Vasquez | 21 | R | 0 | 4 | 8.33 | 12 | 7 | 0 | 0 | 5 | 1 | 0 | 27.0 | 33 | 31 | 25 | 3 | 23 | 22 | 6 | 0 | 5 | 2.07 | 11.00 | 1.00 | 7.67 | 7.33 | 10.33 | 0.96 | 2018- UDFA -CLE | premium | premium | premium | AA | 2018-2025 | 2021 | |
| 52 | Elvis Jerez | 21 | R | 2 | 0 | 2.05 | 20 | 0 | 0 | 0 | 20 | 12 | 1 | 22.0 | 8 | 6 | 5 | 1 | 18 | 44 | 3 | 0 | 2 | 1.18 | 3.27 | 0.41 | 7.36 | 18.00 | 2.45 | 2.44 | 2018- UDFA -CLE | premium | premium | premium | A+ | 2019-2023 | 2021 | |
| 44 | Adam Scott | 25 | L | 0 | 1 | 16.87 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2.2 | 5 | 5 | 5 | 2 | 2 | 5 | 0 | 0 | 0 | 2.62 | 16.87 | 6.75 | 6.75 | 16.87 | 16.87 | 2.50 | 2018- 4- 133-CLE | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 56 | Raymond Burgos | 22 | L | 0 | 0 | 3.86 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 2.1 | 2 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 1.71 | 7.71 | 0.00 | 7.71 | 7.71 | 3.86 | 1.00 | 2016- 18- 542-CLE | premium | premium | premium | MLB | 2024-2024 | 2018-2025 | 2021 |
| - | Eric Mock | 24 | R | 1 | 0 | 0.00 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2.1 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 15.43 | 0.00 | 0.00 | 2019- 25- 760-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | |
| 37 | Serafino Brito | 24 | R | 1 | 0 | 4.50 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2.0 | 5 | 1 | 1 | 0 | 0 | 3 | 1 | 0 | 0 | 2.50 | 22.50 | 0.00 | 0.00 | 13.50 | 4.50 | 0.00 | 2019- 28- 850-CLE | premium | premium | premium | A+ | 2016-2022 | 2021 | |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 47 | Wardquelin Vasquez | 19 | R | 0 | 1 | 2.50 | 11 | 1 | 0 | 0 | 10 | 3 | 0 | 18.0 | 11 | 5 | 5 | 1 | 7 | 24 | 1 | 1 | 0 | 1.00 | 5.50 | 0.50 | 3.50 | 12.00 | 2.50 | 3.43 | 2019- UDFA -CLE | premium | premium | premium | A | 2018-2025 | 2021 | |
| 61 | Euclides Lopez | 20 | R | 1 | 1 | 11.94 | 19 | 0 | 0 | 0 | 19 | 4 | 0 | 17.1 | 22 | 26 | 23 | 0 | 30 | 17 | 10 | 0 | 7 | 3.00 | 11.42 | 0.00 | 15.58 | 8.83 | 13.50 | 0.57 | 2018- UDFA -CLE | premium | premium | premium | Rk | 2018-2021 | 2021 | |
| 69 | Victor Soteldo | 19 | R | 1 | 0 | 3.21 | 10 | 0 | 0 | 0 | 10 | 0 | 0 | 14.0 | 15 | 5 | 5 | 0 | 4 | 12 | 5 | 0 | 0 | 1.36 | 9.64 | 0.00 | 2.57 | 7.71 | 3.21 | 3.00 | 2017- UDFA -CLE | premium | premium | premium | Rk | 2021-2023 | 2021 | |
| 62 | Luis D. Garcia | 21 | R | 1 | 1 | 5.73 | 7 | 0 | 0 | 0 | 7 | 0 | 0 | 11.0 | 14 | 7 | 7 | 3 | 3 | 6 | 0 | 1 | 1 | 1.55 | 11.45 | 2.45 | 2.45 | 4.91 | 5.73 | 2.00 | 2016- UDFA -CLE | premium | premium | premium | Rk | 2017-2021 | 2021 | |
| 54 | Yeury Gervacio | 21 | L | 1 | 0 | 0.00 | 8 | 0 | 0 | 0 | 8 | 4 | 1 | 10.1 | 2 | 1 | 0 | 0 | 2 | 15 | 2 | 0 | 0 | 0.39 | 1.74 | 0.00 | 1.74 | 13.06 | 0.87 | 7.50 | 2017- UDFA -NYN | premium | premium | premium | A | 2018-2025 | 2021 | |
| 52 | Damon Casetta-Stubbs | 21 | R | 1 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 9.00 | 0.00 | 0.00 | 2018- 11- 328-SEA | premium | premium | premium | A+ | 2018-2023 | 2021 | |
| 35 | Victor Planchart | 20 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1.0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1.00 | 0.00 | 0.00 | 9.00 | 9.00 | 0.00 | 1.00 | 2017- UDFA -CLE | premium | premium | premium | A+ | 2018-2023 | 2021 | |
| Totals: | 34 | 23 | 5.47 | 265 | 57 | 0 | 0 | 57 | 208 | 8 | 477.0 | 479 | 341 | 290 | 68 | 247 | 564 | 90 | 7 | 50 | 1.52 | 9.04 | 1.28 | 4.66 | 10.64 | 6.43 | 2.28 | premium | premium | premium |