| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 46 | Aderlin Rodriguez | 29 | 1B-3B | R | 121 | 116 | 434 | 67 | 126 | 26 | 3 | 29 | 94 | 1 | 1 | 42 | 127 | 7 | 0 | 0 | 2 | 14 | 245 | 483 | 58 | 68 | .290 | .362 | .565 | .927 | .371 | .275 | .349 | 8.70 | 26.29 | 3.02 | 14.97 | 2008- UDFA -NYN | premium | premium | premium | AAA | 2009-2025 | 2021 | |
| 23 | Kody Clemens | 25 | 2B | L | 102 | 97 | 369 | 66 | 91 | 15 | 6 | 18 | 59 | 4 | 1 | 36 | 94 | 2 | 0 | 6 | 0 | 4 | 172 | 413 | 39 | 52 | .247 | .312 | .466 | .778 | .325 | .219 | .278 | 8.72 | 22.76 | 2.61 | 20.50 | 2018- 3- 79-DET | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 20 | Christin Stewart | 27 | RF-LF | L | 113 | 89 | 303 | 51 | 77 | 13 | 5 | 21 | 58 | 2 | 1 | 33 | 100 | 6 | 0 | 0 | 5 | 2 | 163 | 342 | 39 | 38 | .254 | .339 | .538 | .877 | .396 | .284 | .308 | 9.65 | 29.24 | 3.03 | 14.43 | 2015- 1- 34-DET | premium | premium | premium | MLB | 2018-2020 | 2013-2022 | 2021 |
| 3 | JaCoby Jones | 29 | CF | R | 91 | 73 | 269 | 31 | 62 | 14 | 0 | 7 | 26 | 1 | 2 | 28 | 103 | 4 | 0 | 0 | 0 | 4 | 97 | 301 | 21 | 41 | .230 | .312 | .361 | .673 | .230 | .131 | .346 | 9.30 | 34.22 | 3.68 | 38.43 | 2013- 3- 87-PIT | premium | premium | premium | MLB | 2016-2021 | 2011-2022 | 2021 |
| 29 | Renato Nunez | 27 | 1B | R | 115 | 74 | 265 | 59 | 77 | 14 | 2 | 20 | 64 | 1 | 0 | 31 | 76 | 11 | 0 | 4 | 0 | 7 | 155 | 311 | 36 | 41 | .291 | .383 | .585 | .968 | .415 | .294 | .329 | 9.97 | 24.44 | 2.45 | 13.25 | 2010- UDFA -OAK | premium | premium | premium | MLB | 2016-2021 | 2011-2025 | 2021 |
| 39 | Yariel Gonzalez | 27 | 3B | B | 102 | 78 | 263 | 45 | 68 | 10 | 0 | 14 | 51 | 0 | 2 | 27 | 65 | 1 | 0 | 4 | 1 | 7 | 120 | 295 | 24 | 44 | .259 | .325 | .456 | .781 | .293 | .197 | .287 | 9.15 | 22.03 | 2.41 | 18.79 | 2016- UDFA -SLN | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 9 | Isaac Paredes | 22 | 3B-2B | R | 114 | 72 | 253 | 39 | 67 | 10 | 2 | 11 | 42 | 0 | 0 | 56 | 47 | 2 | 0 | 4 | 0 | 11 | 114 | 315 | 23 | 44 | .265 | .397 | .451 | .848 | .407 | .186 | .281 | 17.78 | 14.92 | 0.84 | 23.00 | 2015- UDFA -CHN | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 |
| 24 | Jacob Robson | 26 | LF-CF | L | 106 | 78 | 239 | 37 | 62 | 10 | 3 | 5 | 28 | 15 | 9 | 46 | 104 | 3 | 0 | 0 | 0 | 1 | 93 | 288 | 18 | 44 | .259 | .385 | .389 | .774 | .347 | .130 | .438 | 15.97 | 36.11 | 2.26 | 47.80 | 2016- 8- 235-DET | premium | premium | premium | MLB | 2021-2021 | 2013-2025 | 2021 |
| 7 | Cole Peterson | 25 | SS | L | 76 | 58 | 171 | 23 | 34 | 8 | 4 | 0 | 13 | 7 | 2 | 14 | 29 | 2 | 1 | 3 | 1 | 2 | 50 | 191 | 12 | 22 | .199 | .263 | .292 | .555 | .205 | .093 | .234 | 7.33 | 15.18 | 2.07 | 0.00 | 2017- 13- 395-DET | premium | premium | premium | AAA | 2015-2021 | 2021 | |
| 47 | Juan Centeno | 31 | C | L | 94 | 53 | 166 | 15 | 46 | 9 | 1 | 1 | 17 | 0 | 0 | 14 | 25 | 0 | 1 | 0 | 0 | 2 | 60 | 181 | 11 | 35 | .277 | .333 | .361 | .694 | .169 | .084 | .321 | 7.73 | 13.81 | 1.79 | 166.00 | 2007- 32- 991-NYN | premium | premium | premium | MLB | 2013-2019 | 2007-2024 | 2021 |
| 18 | Daz Cameron | 24 | CF | R | 114 | 39 | 162 | 33 | 48 | 11 | 2 | 6 | 23 | 7 | 3 | 15 | 39 | 3 | 0 | 1 | 0 | 2 | 81 | 181 | 19 | 29 | .296 | .365 | .500 | .865 | .321 | .204 | .356 | 8.29 | 21.55 | 2.60 | 27.00 | 2015- 1- 37-HOU | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 12 | Riley Greene | 20 | RF-LF | L | 126 | 40 | 159 | 36 | 49 | 9 | 3 | 8 | 30 | 4 | 0 | 22 | 51 | 3 | 0 | 1 | 1 | 3 | 88 | 185 | 20 | 29 | .308 | .400 | .553 | .953 | .409 | .245 | .406 | 11.89 | 27.57 | 2.32 | 19.88 | 2019- 1- 5-DET | premium | premium | premium | MLB | 2022-2025 | 2019-2025 | 2021 |
| 8 | Zack Short | 26 | SS | R | 114 | 46 | 157 | 30 | 37 | 7 | 0 | 9 | 29 | 2 | 1 | 33 | 47 | 7 | 0 | 1 | 0 | 1 | 71 | 198 | 16 | 21 | .236 | .389 | .452 | .841 | .433 | .216 | .275 | 16.67 | 23.74 | 1.42 | 17.44 | 2016- 17- 524-CHN | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 7 | Spencer Torkelson | 21 | 1B | R | 114 | 40 | 147 | 35 | 35 | 8 | 1 | 11 | 27 | 1 | 0 | 23 | 36 | 4 | 0 | 3 | 1 | 5 | 78 | 177 | 20 | 15 | .238 | .350 | .531 | .881 | .456 | .293 | .233 | 12.99 | 20.34 | 1.57 | 13.36 | 2020- 1- 1-DET | premium | premium | premium | MLB | 2022-2025 | 2018-2025 | 2021 |
| 13 | Ryan Kreidler | 23 | SS | R | 122 | 41 | 135 | 28 | 41 | 8 | 0 | 7 | 22 | 5 | 2 | 24 | 39 | 1 | 0 | 2 | 1 | 1 | 70 | 162 | 15 | 26 | .304 | .407 | .519 | .926 | .415 | .215 | .374 | 14.81 | 24.07 | 1.63 | 19.29 | 2019- 4- 112-DET | premium | premium | premium | MLB | 2022-2025 | 2017-2025 | 2021 |
| 24 | Derek Hill | 25 | CF-LF | R | 117 | 34 | 125 | 21 | 40 | 5 | 3 | 4 | 15 | 4 | 1 | 10 | 39 | 2 | 3 | 1 | 0 | 2 | 63 | 141 | 12 | 28 | .320 | .377 | .504 | .881 | .288 | .184 | .434 | 7.09 | 27.66 | 3.90 | 31.25 | 2014- 1- 23-DET | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 4 | Grayson Greiner | 28 | C | R | 78 | 33 | 119 | 9 | 24 | 6 | 0 | 1 | 9 | 0 | 0 | 13 | 49 | 1 | 0 | 1 | 0 | 2 | 33 | 134 | 7 | 17 | .202 | .284 | .277 | .561 | .185 | .075 | .329 | 9.70 | 36.57 | 3.77 | 119.00 | 2014- 3- 99-DET | premium | premium | premium | MLB | 2018-2022 | 2012-2023 | 2021 |
| 49 | Brady Policelli | 26 | C | R | 53* | 37 | 109 | 9 | 11 | 3 | 0 | 2 | 13 | 1 | 0 | 11 | 41 | 0 | 1 | 0 | 0 | 4 | 20 | 121 | 5 | 6 | .101 | .183 | .183 | .366 | .193 | .082 | .136 | 9.09 | 33.88 | 3.73 | 54.50 | 2016- 13- 385-DET | premium | premium | premium | AAA | 2014-2022 | 2021 | |
| 29 | Josh Lester | 26 | RF | L | 101* | 25 | 88 | 9 | 19 | 4 | 0 | 7 | 13 | 0 | 0 | 7 | 19 | 0 | 0 | 0 | 0 | 1 | 44 | 95 | 11 | 8 | .216 | .274 | .500 | .774 | .364 | .284 | .194 | 7.37 | 20.00 | 2.71 | 12.57 | 2015- 13- 400-DET | premium | premium | premium | MLB | 2022-2023 | 2013-2025 | 2021 |
| 16 | Victor Reyes | 26 | CF-LF | B | 135* | 20 | 78 | 13 | 30 | 7 | 2 | 1 | 10 | 5 | 2 | 10 | 17 | 2 | 0 | 1 | 0 | 2 | 44 | 91 | 10 | 20 | .385 | .462 | .564 | 1.026 | .346 | .179 | .475 | 10.99 | 18.68 | 1.70 | 78.00 | 2011- UDFA -ATL | premium | premium | premium | MLB | 2018-2022 | 2012-2023 | 2021 |
| - | Niko Goodrum | 29 | SS-CF | B | 14 | 54 | 7 | 10 | 0 | 0 | 0 | 2 | 1 | 0 | 7 | 16 | 0 | 0 | 1 | 0 | 1 | 10 | 62 | 0 | 10 | .185 | .274 | .185 | .459 | .148 | .000 | .256 | 11.29 | 25.81 | 2.29 | 0.00 | 2010- 2- 71-MIN | premium | premium | premium | MLB | 2017-2024 | 2010-2025 | 2021 | |
| 13 | Dustin Garneau | 33 | C | R | 17 | 51 | 8 | 9 | 1 | 0 | 4 | 9 | 0 | 0 | 7 | 20 | 1 | 0 | 1 | 0 | 1 | 22 | 60 | 5 | 4 | .176 | .283 | .431 | .714 | .392 | .255 | .179 | 11.67 | 33.33 | 2.86 | 12.75 | 2009- 19- 571-COL | premium | premium | premium | MLB | 2015-2022 | 2006-2022 | 2021 | |
| 2 | Dylan Rosa | 25 | RF | R | 19 | 50 | 8 | 12 | 5 | 1 | 0 | 2 | 0 | 0 | 1 | 19 | 2 | 0 | 0 | 0 | 2 | 19 | 53 | 6 | 6 | .240 | .283 | .380 | .663 | .160 | .140 | .387 | 1.89 | 35.85 | 19.00 | 0.00 | 2017- 18- 545-DET | premium | premium | premium | AAA | 2015-2023 | 2021 | ||
| 49 | Chris Proctor | 24 | RF | L | 15 | 34 | 6 | 7 | 0 | 0 | 0 | 3 | 0 | 0 | 1 | 13 | 0 | 0 | 0 | 0 | 0 | 7 | 35 | 0 | 7 | .206 | .229 | .206 | .435 | .029 | .000 | .333 | 2.86 | 37.14 | 13.00 | 0.00 | 2018- 13- 375-DET | premium | premium | premium | AAA | 2016-2024 | 2021 | ||
| 22 | Daniel Pinero | 27 | 2B-3B | R | 11 | 30 | 6 | 6 | 4 | 0 | 1 | 5 | 0 | 0 | 6 | 9 | 1 | 0 | 1 | 0 | 0 | 13 | 38 | 5 | 1 | .200 | .342 | .433 | .775 | .433 | .233 | .238 | 15.79 | 23.68 | 1.50 | 30.00 | 2016- 9- 265-DET | premium | premium | premium | AAA | 2014-2021 | 2021 | ||
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 8 | Jon Rosoff | 26 | C | L | 10 | 24 | 4 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 6 | 12 | 1 | 1 | 0 | 0 | 1 | 2 | 32 | 0 | 2 | .083 | .290 | .083 | .373 | .292 | .000 | .167 | 18.75 | 37.50 | 2.00 | 0.00 | 2018- UDFA -DET | premium | premium | premium | AAA | 2015-2022 | 2021 | ||
| 18 | Eric Haase | 28 | C-LF | R | 7 | 23 | 3 | 8 | 3 | 0 | 1 | 5 | 1 | 0 | 5 | 10 | 0 | 0 | 0 | 0 | 1 | 14 | 28 | 4 | 4 | .348 | .464 | .609 | 1.073 | .522 | .261 | .583 | 17.86 | 35.71 | 2.00 | 23.00 | 2011- 7- 218-CLE | premium | premium | premium | MLB | 2018-2025 | 2011-2025 | 2021 | |
| 13 | Willi Castro | 24 | 2B | B | 5 | 23 | 7 | 9 | 2 | 0 | 1 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 14 | 23 | 3 | 6 | .391 | .391 | .609 | 1.000 | .304 | .218 | .400 | 0.00 | 8.70 | 0.00 | 23.00 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 | |
| 21 | Akil Baddoo | 22 | LF-CF | L | 4 | 14 | 2 | 2 | 1 | 0 | 0 | 2 | 1 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 18 | 1 | 1 | .143 | .333 | .214 | .547 | .429 | .071 | .222 | 22.22 | 27.78 | 1.25 | 0.00 | 2016- 2- 74-MIN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 | |
| 5 | Nomar Mazara | 26 | RF | L | 3 | 12 | 2 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 5 | 13 | 1 | 1 | .167 | .231 | .417 | .648 | .333 | .250 | .111 | 7.69 | 15.38 | 2.00 | 12.00 | 2011- UDFA -TEX | premium | premium | premium | MLB | 2016-2022 | 2012-2025 | 2021 | |
| 7 | Jake Rogers | 26 | C | R | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .250 | .000 | .250 | .333 | .000 | .000 | 25.00 | 75.00 | 3.00 | 0.00 | 2016- 3- 97-HOU | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 | |
| Totals: | 1249 | 4329 | 710 | 1111 | 213 | 38 | 190 | 677 | 66 | 27 | 534 | 1258 | 66 | 7 | 35 | 12 | 83 | 1970 | 4971 | 441 | 670 | .257 | .345 | .455 | .800 | .331 | .198 | .316 | 10.74 | 25.31 | 2.36 | 22.78 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 30 | Ricardo Pinto | 27 | R | 11 | 3 | 4.63 | 18 | 17 | 0 | 0 | 1 | 0 | 0 | 95.1 | 100 | 55 | 49 | 13 | 40 | 82 | 6 | 3 | 7 | 1.47 | 9.44 | 1.23 | 3.78 | 7.74 | 5.19 | 2.05 | 2011- UDFA -PHI | premium | premium | premium | MLB | 2017-2024 | 2014-2025 | 2021 |
| 50 | Pedro Payano | 26 | R | 5 | 7 | 5.12 | 19 | 18 | 0 | 0 | 1 | 0 | 0 | 95.0 | 91 | 58 | 54 | 12 | 54 | 81 | 4 | 0 | 8 | 1.53 | 8.62 | 1.14 | 5.12 | 7.67 | 5.49 | 1.50 | 2012- UDFA -TEX | premium | premium | premium | MLB | 2019-2019 | 2012-2025 | 2021 |
| 16 | Matthew Boyd | 30 | L | 0 | 0 | 0.00 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 9.1 | 5 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | 0.54 | 4.82 | 0.00 | 0.00 | 10.61 | 0.00 | 0.00 | 2013- 6- 175-TOR | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 |
| 53 | Mark Leiter | 30 | R | 8 | 4 | 3.34 | 17 | 15 | 0 | 0 | 2 | 0 | 0 | 89.0 | 67 | 38 | 33 | 10 | 23 | 110 | 5 | 0 | 8 | 1.01 | 6.78 | 1.01 | 2.33 | 11.12 | 3.84 | 4.78 | 2013- 22- 661-PHI | premium | premium | premium | MLB | 2017-2025 | 2010-2025 | 2021 |
| 10 | Drew Hutchison | 30 | R | 8 | 3 | 3.77 | 19 | 19 | 0 | 0 | 0 | 0 | 0 | 88.1 | 78 | 42 | 37 | 8 | 41 | 89 | 7 | 1 | 6 | 1.35 | 7.95 | 0.82 | 4.18 | 9.07 | 4.28 | 2.17 | 2009- 15- 460-TOR | premium | premium | premium | MLB | 2012-2022 | 2010-2024 | 2021 |
| 18 | Erasmo Ramirez | 31 | R | 1 | 0 | 3.38 | 5 | 0 | 0 | 0 | 5 | 0 | 0 | 8.0 | 4 | 3 | 3 | 0 | 3 | 10 | 4 | 0 | 0 | 0.88 | 4.50 | 0.00 | 3.38 | 11.25 | 3.38 | 3.33 | 2007- UDFA -SEA | premium | premium | premium | MLB | 2012-2025 | 2010-2025 | 2021 |
| 35 | Logan Shore | 26 | R | 7 | 3 | 3.95 | 16 | 15 | 0 | 0 | 1 | 0 | 0 | 73.0 | 65 | 32 | 32 | 6 | 30 | 64 | 5 | 0 | 2 | 1.30 | 8.01 | 0.74 | 3.70 | 7.89 | 3.95 | 2.13 | 2016- 2- 47-OAK | premium | premium | premium | AAA | 2014-2023 | 2021 | |
| 33 | Joe Navilhon | 27 | R | 0 | 0 | 8.22 | 6 | 0 | 0 | 0 | 6 | 1 | 0 | 7.2 | 12 | 8 | 7 | 0 | 4 | 6 | 3 | 0 | 1 | 2.09 | 14.09 | 0.00 | 4.70 | 7.04 | 9.39 | 1.50 | 2016- 21- 625-DET | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 21 | A.J. Ladwig | 28 | R | 0 | 0 | 0.00 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 7.0 | 3 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0.43 | 3.86 | 0.00 | 0.00 | 6.43 | 0.00 | 0.00 | 2014- 11- 340-DET | premium | premium | premium | MLB | 2022-2022 | 2012-2022 | 2021 |
| 32 | Nolan Blackwood | 26 | R | 5 | 0 | 4.92 | 37 | 2 | 0 | 0 | 35 | 8 | 1 | 60.1 | 62 | 40 | 33 | 5 | 23 | 51 | 4 | 2 | 2 | 1.41 | 9.25 | 0.75 | 3.43 | 7.61 | 5.97 | 2.22 | 2016- 14- 412-OAK | premium | premium | premium | AAA | 2014-2025 | 2021 | |
| 41 | Locke St. John | 28 | L | 4 | 0 | 2.58 | 36 | 5 | 0 | 0 | 31 | 8 | 2 | 59.1 | 53 | 17 | 17 | 4 | 25 | 75 | 2 | 0 | 2 | 1.31 | 8.04 | 0.61 | 3.79 | 11.38 | 2.58 | 3.00 | 2014- 32- 970-DET | premium | premium | premium | MLB | 2019-2022 | 2014-2022 | 2021 |
| 18 | Drew Carlton | 25 | R | 3 | 3 | 2.92 | 33 | 2 | 0 | 0 | 31 | 11 | 4 | 52.1 | 46 | 22 | 17 | 5 | 10 | 49 | 1 | 0 | 0 | 1.07 | 7.91 | 0.86 | 1.72 | 8.43 | 3.78 | 4.90 | 2017- 32- 965-DET | premium | premium | premium | MLB | 2021-2023 | 2015-2023 | 2021 |
| 5 | Angel De Jesus | 24 | R | 3 | 4 | 4.21 | 35 | 2 | 0 | 0 | 33 | 11 | 5 | 51.1 | 32 | 27 | 24 | 7 | 32 | 62 | 4 | 1 | 9 | 1.25 | 5.61 | 1.23 | 5.61 | 10.87 | 4.73 | 1.94 | 2016- UDFA -DET | premium | premium | premium | MLB | 2022-2022 | 2016-2025 | 2021 |
| 31 | Wladimir Pinto | 23 | R | 3 | 4 | 4.62 | 37 | 3 | 0 | 0 | 34 | 13 | 4 | 50.2 | 38 | 32 | 26 | 9 | 35 | 60 | 7 | 0 | 4 | 1.44 | 6.75 | 1.60 | 6.22 | 10.66 | 5.68 | 1.71 | 2014- UDFA -DET | premium | premium | premium | AAA | 2016-2024 | 2021 | |
| 18 | Ethan DeCaster | 26 | R | 0 | 0 | 7.71 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 4.2 | 7 | 4 | 4 | 0 | 2 | 5 | 0 | 0 | 1 | 1.93 | 13.50 | 0.00 | 3.86 | 9.64 | 7.71 | 2.50 | 2018- 18- 525-DET | premium | premium | premium | AAA | 2015-2021 | 2021 | |
| 18 | Derek Holland | 34 | L | 0 | 0 | 6.75 | 4 | 1 | 0 | 0 | 3 | 0 | 0 | 4.0 | 5 | 3 | 3 | 2 | 3 | 4 | 0 | 0 | 2 | 2.00 | 11.25 | 4.50 | 6.75 | 9.00 | 6.75 | 1.33 | 2006- 25- 748-TEX | premium | premium | premium | MLB | 2009-2021 | 2007-2023 | 2021 |
| 37 | Miguel Del Pozo | 28 | L | 1 | 3 | 2.82 | 34 | 0 | 0 | 0 | 34 | 16 | 4 | 38.1 | 22 | 12 | 12 | 6 | 16 | 54 | 5 | 0 | 2 | 0.99 | 5.17 | 1.41 | 3.76 | 12.68 | 2.82 | 3.38 | 2010- UDFA -MIA | premium | premium | premium | MLB | 2019-2021 | 2011-2023 | 2021 |
| 43 | Nivaldo Rodriguez | 24 | R | 2 | 1 | 4.93 | 13 | 5 | 0 | 0 | 8 | 1 | 0 | 34.2 | 40 | 25 | 19 | 6 | 12 | 19 | 2 | 0 | 0 | 1.50 | 10.38 | 1.56 | 3.12 | 4.93 | 6.49 | 1.58 | 2016- UDFA -HOU | premium | premium | premium | MLB | 2020-2021 | 2016-2023 | 2021 |
| 45 | Jason Foley | 25 | R | 1 | 1 | 4.41 | 32 | 0 | 0 | 0 | 32 | 9 | 2 | 34.2 | 34 | 18 | 17 | 5 | 19 | 36 | 5 | 0 | 4 | 1.53 | 8.83 | 1.30 | 4.93 | 9.35 | 4.67 | 1.89 | 2016- UDFA -DET | premium | premium | premium | MLB | 2021-2024 | 2014-2025 | 2021 |
| 25 | Matt Manning | 23 | R | 1 | 3 | 8.07 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 32.1 | 40 | 29 | 29 | 11 | 10 | 36 | 2 | 0 | 0 | 1.55 | 11.13 | 3.06 | 2.78 | 10.02 | 8.07 | 3.60 | 2016- 1- 9-DET | premium | premium | premium | MLB | 2021-2024 | 2016-2025 | 2021 |
| 12 | Robbie Ross | 32 | L | 2 | 8 | 7.03 | 27 | 1 | 0 | 0 | 26 | 13 | 2 | 32.0 | 40 | 29 | 25 | 6 | 10 | 26 | 0 | 0 | 4 | 1.56 | 11.25 | 1.69 | 2.81 | 7.31 | 8.16 | 2.60 | 2008- 2- 57-TEX | premium | premium | premium | MLB | 2012-2017 | 2009-2023 | 2021 |
| 22 | Jose Urena | 29 | R | 0 | 0 | 0.00 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0.33 | 0.00 | 0.00 | 3.00 | 6.00 | 0.00 | 2.00 | 2008- UDFA -MIA | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 |
| 48 | Will Vest | 26 | R | 1 | 3 | 4.91 | 23 | 0 | 0 | 0 | 23 | 11 | 2 | 25.2 | 27 | 14 | 14 | 3 | 8 | 25 | 0 | 0 | 0 | 1.36 | 9.47 | 1.05 | 2.81 | 8.77 | 4.91 | 3.13 | 2017- 12- 365-DET | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 21 | Ian Krol | 30 | L | 2 | 0 | 2.45 | 20 | 1 | 0 | 0 | 19 | 9 | 4 | 25.2 | 20 | 8 | 7 | 4 | 12 | 31 | 2 | 0 | 2 | 1.25 | 7.01 | 1.40 | 4.21 | 10.87 | 2.81 | 2.58 | 2009- 7- 213-OAK | premium | premium | premium | MLB | 2013-2021 | 2009-2025 | 2021 |
| 6 | Bryan Garcia | 26 | R | 0 | 1 | 5.40 | 19 | 0 | 0 | 0 | 19 | 7 | 1 | 23.1 | 25 | 15 | 14 | 3 | 8 | 19 | 4 | 0 | 2 | 1.41 | 9.64 | 1.16 | 3.09 | 7.33 | 5.79 | 2.38 | 2016- 6- 175-DET | premium | premium | premium | MLB | 2019-2022 | 2014-2024 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 33 | Alex Lange | 25 | R | 2 | 1 | 4.57 | 19 | 0 | 0 | 0 | 19 | 1 | 1 | 21.2 | 22 | 12 | 11 | 0 | 17 | 27 | 7 | 0 | 0 | 1.80 | 9.14 | 0.00 | 7.06 | 11.22 | 4.98 | 1.59 | 2017- 1- 30-CHN | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 49 | Henry Martinez | 27 | R | 2 | 0 | 6.20 | 14 | 0 | 0 | 0 | 14 | 3 | 0 | 20.1 | 22 | 14 | 14 | 2 | 12 | 23 | 3 | 0 | 0 | 1.67 | 9.74 | 0.89 | 5.31 | 10.18 | 6.20 | 1.92 | 2013- UDFA -CLE | premium | premium | premium | AAA | 2014-2022 | 2021 | |
| 58 | Gerson Moreno | 25 | R | 0 | 0 | 6.75 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2.2 | 2 | 2 | 2 | 0 | 5 | 5 | 0 | 0 | 1 | 2.62 | 6.75 | 0.00 | 16.87 | 16.87 | 6.75 | 1.00 | 2012- UDFA -DET | premium | premium | premium | AAA | 2013-2025 | 2021 | |
| 18 | Elvin Rodriguez | 23 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2.0 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0.50 | 4.50 | 0.00 | 0.00 | 13.50 | 0.00 | 0.00 | 2014- UDFA -ANA | premium | premium | premium | MLB | 2022-2025 | 2015-2025 | 2021 |
| 58 | Michael Fulmer | 28 | R | 0 | 0 | 0.00 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 2.0 | 1 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 1.50 | 4.50 | 0.00 | 9.00 | 9.00 | 0.00 | 1.00 | 2011- 1- 44-NYN | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 19 | Brad Bass | 25 | R | 0 | 0 | 0.00 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2.0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1.00 | 4.50 | 0.00 | 4.50 | 9.00 | 0.00 | 2.00 | 2017- 7- 215-DET | premium | premium | premium | AAA | 2015-2021 | 2021 | |
| 38 | Wily Peralta | 32 | R | 1 | 0 | 2.75 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 19.2 | 15 | 6 | 6 | 2 | 8 | 21 | 1 | 0 | 1 | 1.17 | 6.86 | 0.92 | 3.66 | 9.61 | 2.75 | 2.63 | 2005- UDFA -MIL | premium | premium | premium | MLB | 2012-2022 | 2006-2025 | 2021 |
| 51 | Rony Garcia | 23 | R | 0 | 1 | 3.20 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 19.2 | 13 | 7 | 7 | 4 | 10 | 24 | 0 | 0 | 3 | 1.17 | 5.95 | 1.83 | 4.58 | 10.98 | 3.20 | 2.40 | 2015- UDFA -NYA | premium | premium | premium | MLB | 2020-2022 | 2016-2023 | 2021 |
| 33 | Beau Burrows | 24 | R | 1 | 1 | 6.23 | 9 | 1 | 0 | 0 | 8 | 0 | 0 | 17.1 | 21 | 12 | 12 | 4 | 6 | 17 | 1 | 0 | 0 | 1.56 | 10.90 | 2.08 | 3.12 | 8.83 | 6.23 | 2.83 | 2015- 1- 22-DET | premium | premium | premium | MLB | 2020-2021 | 2015-2025 | 2021 |
| 26 | Buck Farmer | 30 | R | 0 | 2 | 3.97 | 9 | 0 | 0 | 0 | 9 | 4 | 0 | 11.1 | 11 | 5 | 5 | 0 | 4 | 7 | 1 | 0 | 1 | 1.32 | 8.74 | 0.00 | 3.18 | 5.56 | 3.97 | 1.75 | 2013- 5- 156-DET | premium | premium | premium | MLB | 2014-2024 | 2010-2025 | 2021 |
| 17 | Joe Jimenez | 26 | R | 0 | 0 | 9.00 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1.0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1.00 | 9.00 | 9.00 | 0.00 | 9.00 | 9.00 | 0.00 | 2013- UDFA -DET | premium | premium | premium | MLB | 2017-2024 | 2013-2024 | 2021 |
| 8 | Jon Rosoff | 26 | R | 0 | 0 | 27.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0.1 | 2 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 6.00 | 54.00 | 0.00 | 0.00 | 0.00 | 27.00 | 0.00 | 2018- UDFA -DET | premium | premium | premium | AAA | 2015-2022 | 2021 | |
| Totals: | 74 | 56 | 4.28 | 539 | 130 | 0 | 0 | 130 | 409 | 33 | 1125.0 | 1028 | 591 | 535 | 138 | 486 | 1144 | 88 | 7 | 72 | 1.35 | 8.22 | 1.10 | 3.89 | 9.15 | 4.73 | 2.35 | premium | premium | premium |