| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 13 | Gabriel Arias | 21 | SS | R | 107 | 115 | 436 | 64 | 124 | 29 | 3 | 13 | 55 | 5 | 1 | 39 | 110 | 5 | 0 | 3 | 0 | 10 | 198 | 483 | 45 | 79 | .284 | .348 | .454 | .802 | .268 | .170 | .351 | 8.07 | 22.77 | 2.82 | 33.54 | 2016- UDFA -SDN | premium | premium | premium | MLB | 2022-2025 | 2017-2025 | 2021 |
| 10,95 | Nolan Jones | 23 | 3B | L | 107 | 99 | 341 | 60 | 81 | 25 | 1 | 13 | 48 | 10 | 2 | 59 | 122 | 5 | 0 | 2 | 1 | 7 | 147 | 407 | 39 | 42 | .238 | .356 | .431 | .787 | .390 | .193 | .327 | 14.50 | 29.98 | 2.07 | 26.23 | 2016- 2- 55-CLE | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 24 | Connor Marabell | 27 | LF | L | 103 | 99 | 337 | 41 | 98 | 23 | 2 | 8 | 49 | 4 | 4 | 18 | 65 | 6 | 0 | 2 | 0 | 9 | 149 | 363 | 33 | 65 | .291 | .336 | .442 | .778 | .205 | .151 | .338 | 4.96 | 17.91 | 3.61 | 42.13 | 2015- 25- 754-CLE | premium | premium | premium | AAA | 2013-2021 | 2021 | |
| 45 | Oscar Gonzalez | 23 | RF | R | 106 | 72 | 290 | 39 | 78 | 12 | 1 | 18 | 42 | 0 | 1 | 11 | 76 | 4 | 0 | 0 | 0 | 4 | 146 | 305 | 31 | 47 | .269 | .305 | .503 | .808 | .269 | .234 | .306 | 3.61 | 24.92 | 6.91 | 16.11 | 2014- UDFA -CLE | premium | premium | premium | MLB | 2022-2025 | 2015-2025 | 2021 |
| 38 | Trenton Brooks | 25 | 1B | L | 99 | 79 | 289 | 42 | 73 | 23 | 0 | 8 | 37 | 2 | 0 | 31 | 67 | 1 | 2 | 2 | 1 | 4 | 120 | 325 | 31 | 42 | .253 | .325 | .415 | .740 | .277 | .162 | .301 | 9.54 | 20.62 | 2.16 | 36.13 | 2016- 17- 512-CLE | premium | premium | premium | MLB | 2024-2025 | 2014-2025 | 2021 |
| 10 | Daniel Johnson | 25 | RF-CF | L | 102 | 72 | 279 | 36 | 62 | 16 | 2 | 14 | 39 | 7 | 1 | 35 | 106 | 3 | 0 | 1 | 0 | 1 | 124 | 318 | 32 | 30 | .222 | .314 | .444 | .758 | .369 | .222 | .300 | 11.01 | 33.33 | 3.03 | 19.93 | 2016- 5- 154-WAS | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 7 | Alex Call | 26 | CF | R | 98 | 66 | 231 | 34 | 53 | 8 | 0 | 10 | 27 | 3 | 3 | 33 | 38 | 4 | 0 | 1 | 0 | 5 | 91 | 269 | 18 | 35 | .229 | .335 | .394 | .729 | .307 | .165 | .234 | 12.27 | 14.13 | 1.15 | 23.10 | 2016- 3- 86-CHA | premium | premium | premium | MLB | 2022-2025 | 2014-2025 | 2021 |
| 1,6 | Andres Gimenez | 22 | SS-2B | L | 111 | 52 | 209 | 30 | 60 | 13 | 1 | 10 | 31 | 8 | 4 | 12 | 55 | 6 | 5 | 1 | 1 | 1 | 105 | 233 | 24 | 36 | .287 | .342 | .502 | .844 | .292 | .215 | .345 | 5.15 | 23.61 | 4.58 | 20.90 | 2015- UDFA -NYN | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 |
| 6 | Owen Miller | 24 | 2B | R | 114 | 48 | 182 | 25 | 54 | 12 | 1 | 7 | 22 | 0 | 0 | 21 | 52 | 2 | 0 | 1 | 0 | 6 | 89 | 206 | 20 | 34 | .297 | .374 | .489 | .863 | .308 | .192 | .379 | 10.19 | 25.24 | 2.48 | 26.00 | 2018- 3- 84-SDN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 36 | Ryan Lavarnway | 33 | C | R | 112 | 49 | 177 | 29 | 46 | 7 | 0 | 13 | 40 | 0 | 0 | 20 | 54 | 1 | 0 | 0 | 1 | 3 | 92 | 198 | 20 | 26 | .260 | .338 | .520 | .858 | .373 | .260 | .300 | 10.10 | 27.27 | 2.70 | 13.62 | 2008- 6- 202-BOS | premium | premium | premium | MLB | 2011-2021 | 2006-2023 | 2021 |
| 12 | Tyler Krieger | 27 | 2B | B | 63 | 60 | 172 | 16 | 29 | 6 | 0 | 2 | 9 | 1 | 2 | 10 | 57 | 2 | 0 | 0 | 0 | 3 | 41 | 184 | 8 | 21 | .169 | .223 | .238 | .461 | .122 | .069 | .239 | 5.43 | 30.98 | 5.70 | 86.00 | 2015- 4- 124-CLE | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 2 | Oscar Mercado | 26 | CF-LF | R | 99 | 45 | 171 | 29 | 37 | 13 | 1 | 5 | 23 | 9 | 1 | 23 | 32 | 6 | 1 | 2 | 0 | 2 | 67 | 203 | 19 | 18 | .216 | .327 | .392 | .719 | .357 | .176 | .235 | 11.33 | 15.76 | 1.39 | 34.20 | 2013- 2- 57-SLN | premium | premium | premium | MLB | 2019-2023 | 2013-2025 | 2021 |
| 8 | Gavin Collins | 25 | C | R | 84 | 50 | 148 | 16 | 27 | 3 | 0 | 5 | 22 | 1 | 1 | 19 | 44 | 6 | 0 | 1 | 0 | 2 | 45 | 174 | 8 | 19 | .182 | .299 | .304 | .603 | .250 | .122 | .220 | 10.92 | 25.29 | 2.32 | 29.60 | 2016- 13- 392-CLE | premium | premium | premium | AAA | 2014-2025 | 2021 | |
| 1,10 | Ernie Clement | 25 | 3B-SS | R | 90 | 33 | 124 | 11 | 31 | 12 | 1 | 1 | 10 | 2 | 1 | 9 | 22 | 0 | 2 | 3 | 0 | 2 | 48 | 138 | 14 | 17 | .250 | .294 | .387 | .681 | .218 | .137 | .288 | 6.52 | 15.94 | 2.44 | 124.00 | 2017- 4- 132-CLE | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 1 | Richie Palacios | 24 | 2B | L | 120 | 37 | 113 | 19 | 33 | 9 | 1 | 1 | 12 | 10 | 0 | 25 | 28 | 4 | 2 | 1 | 0 | 1 | 47 | 145 | 11 | 22 | .292 | .434 | .416 | .850 | .434 | .124 | .376 | 17.24 | 19.31 | 1.12 | 113.00 | 2018- 3- 103-CLE | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 6 | Andruw Monasterio | 24 | 3B | R | 109* | 33 | 111 | 23 | 31 | 12 | 0 | 1 | 10 | 1 | 0 | 18 | 37 | 1 | 0 | 0 | 0 | 2 | 46 | 130 | 13 | 18 | .279 | .385 | .414 | .799 | .306 | .135 | .411 | 13.85 | 28.46 | 2.06 | 111.00 | 2014- UDFA -CHN | premium | premium | premium | MLB | 2023-2025 | 2015-2025 | 2021 |
| 2 | Steven Kwan | 23 | CF | L | 121* | 26 | 103 | 23 | 32 | 3 | 1 | 5 | 13 | 2 | 0 | 14 | 8 | 1 | 2 | 0 | 0 | 1 | 52 | 120 | 9 | 23 | .311 | .398 | .505 | .903 | .350 | .194 | .300 | 11.67 | 6.67 | 0.57 | 20.60 | 2018- 5- 163-CLE | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 44 | Bobby Bradley | 25 | 1B | L | 98* | 26 | 97 | 16 | 19 | 1 | 0 | 9 | 19 | 0 | 0 | 7 | 35 | 3 | 0 | 2 | 0 | 0 | 47 | 109 | 10 | 9 | .196 | .266 | .485 | .751 | .361 | .289 | .182 | 6.42 | 32.11 | 5.00 | 10.78 | 2014- 3- 97-CLE | premium | premium | premium | MLB | 2019-2022 | 2014-2025 | 2021 |
| 44 | Will Benson | 23 | LF-CF | L | 79* | 27 | 93 | 7 | 15 | 5 | 1 | 3 | 9 | 0 | 2 | 14 | 42 | 0 | 0 | 0 | 1 | 2 | 31 | 107 | 9 | 6 | .161 | .271 | .333 | .604 | .301 | .172 | .250 | 13.08 | 39.25 | 3.00 | 31.00 | 2016- 1- 14-CLE | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 29 | Mike Rivera | 25 | C | R | 74* | 23 | 74 | 4 | 17 | 3 | 0 | 0 | 8 | 0 | 0 | 4 | 18 | 0 | 0 | 0 | 0 | 5 | 20 | 78 | 3 | 14 | .230 | .269 | .270 | .539 | .095 | .040 | .304 | 5.13 | 23.08 | 4.50 | 0.00 | 2017- 6- 192-CLE | premium | premium | premium | AAA | 2015-2022 | 2021 | |
| 11 | Bradley Zimmer | 28 | RF-CF | L | 109* | 18 | 60 | 9 | 16 | 3 | 0 | 1 | 8 | 4 | 2 | 10 | 26 | 5 | 0 | 0 | 0 | 0 | 22 | 75 | 4 | 12 | .267 | .413 | .367 | .780 | .300 | .100 | .455 | 13.33 | 34.67 | 2.60 | 60.00 | 2014- 1- 21-CLE | premium | premium | premium | MLB | 2017-2022 | 2012-2023 | 2021 |
| 40 | Wilson Ramos | 33 | C | R | 16 | 60 | 6 | 19 | 3 | 0 | 3 | 9 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 4 | 31 | 61 | 6 | 13 | .317 | .328 | .517 | .845 | .217 | .200 | .314 | 1.64 | 9.84 | 6.00 | 20.00 | 2004- UDFA -MIN | premium | premium | premium | MLB | 2010-2021 | 2006-2023 | 2021 | |
| 2 | Yu Chang | 25 | 3B-SS | R | 15 | 59 | 9 | 19 | 5 | 0 | 4 | 13 | 1 | 2 | 5 | 19 | 2 | 0 | 0 | 0 | 1 | 36 | 66 | 9 | 10 | .322 | .394 | .610 | 1.004 | .356 | .288 | .417 | 7.58 | 28.79 | 3.80 | 14.75 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2019-2023 | 2014-2024 | 2021 | |
| 8,65 | Roberto Perez | 32 | C | R | 9 | 24 | 3 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 6 | 7 | 0 | 0 | 1 | 0 | 1 | 3 | 31 | 0 | 3 | .125 | .290 | .125 | .415 | .250 | .000 | .167 | 19.35 | 22.58 | 1.17 | 0.00 | 2008- 33-1011-CLE | premium | premium | premium | MLB | 2014-2023 | 2009-2025 | 2021 | |
| 46 | Jordan Luplow | 27 | LF | R | 8 | 23 | 6 | 6 | 4 | 0 | 2 | 7 | 0 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 1 | 16 | 28 | 6 | 0 | .261 | .393 | .696 | 1.089 | .652 | .435 | .235 | 17.86 | 14.29 | 0.80 | 11.50 | 2014- 3- 100-PIT | premium | premium | premium | MLB | 2017-2023 | 2012-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 36 | Bryan Lavastida | 22 | C | R | 7 | 19 | 2 | 3 | 0 | 0 | 1 | 3 | 0 | 0 | 2 | 10 | 0 | 0 | 0 | 0 | 1 | 6 | 21 | 1 | 2 | .158 | .238 | .316 | .554 | .263 | .158 | .250 | 9.52 | 47.62 | 5.00 | 19.00 | 2018- 15- 463-CLE | premium | premium | premium | MLB | 2022-2022 | 2018-2025 | 2021 | |
| 46 | Angel Lopez | 24 | C-P | R | 5 | 13 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 13 | 2 | 0 | .154 | .154 | .308 | .462 | .154 | .154 | .286 | 0.00 | 46.15 | 0.00 | 0.00 | 2017- 13- 402-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | ||
| 22 | Franmil Reyes | 25 | DH | R | 4 | 12 | 1 | 4 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 7 | 12 | 1 | 3 | .333 | .333 | .583 | .916 | .250 | .250 | .333 | 0.00 | 16.67 | 0.00 | 12.00 | 2011- UDFA -SDN | premium | premium | premium | MLB | 2018-2023 | 2012-2025 | 2021 | |
| - | Jose Fermin | 22 | 2B | R | 4 | 11 | 4 | 4 | 1 | 0 | 1 | 2 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 8 | 12 | 2 | 2 | .364 | .417 | .727 | 1.144 | .455 | .363 | .500 | 8.33 | 33.33 | 4.00 | 11.00 | 2015- UDFA -CLE | premium | premium | premium | MLB | 2023-2025 | 2016-2025 | 2021 | |
| 28 | Ben Gamel | 29 | LF | L | 1 | 5 | 1 | 3 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 5 | 1 | 2 | .600 | .600 | .800 | 1.400 | .400 | .200 | .600 | 0.00 | 0.00 | 0.00 | 0.00 | 2010- 10- 325-NYA | premium | premium | premium | MLB | 2016-2024 | 2010-2025 | 2021 | |
| 46 | Gianpaul Gonzalez | 25 | C | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2014- 20- 608-CLE | premium | premium | premium | AAA | 2014-2021 | 2021 | ||
| Totals: | 1199 | 4264 | 605 | 1079 | 254 | 16 | 159 | 574 | 71 | 27 | 452 | 1153 | 67 | 14 | 23 | 5 | 79 | 1842 | 4820 | 429 | 650 | .253 | .333 | .432 | .764 | .295 | .179 | .309 | 9.38 | 23.92 | 2.55 | 26.82 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 27 | Alex Young | 27 | L | 0 | 0 | 5.00 | 8 | 0 | 0 | 0 | 8 | 2 | 0 | 9.0 | 8 | 5 | 5 | 1 | 4 | 7 | 2 | 0 | 0 | 1.33 | 8.00 | 1.00 | 4.00 | 7.00 | 5.00 | 1.75 | 2015- 2- 43-ARI | premium | premium | premium | MLB | 2019-2024 | 2013-2024 | 2021 |
| 29 | Ben Krauth | 27 | L | 1 | 0 | 3.00 | 5 | 1 | 0 | 0 | 4 | 1 | 0 | 9.0 | 7 | 3 | 3 | 0 | 5 | 9 | 1 | 0 | 0 | 1.33 | 7.00 | 0.00 | 5.00 | 9.00 | 3.00 | 1.80 | 2016- 16- 482-CLE | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 11 | Heath Fillmyer | 27 | R | 4 | 7 | 6.18 | 21 | 16 | 0 | 0 | 5 | 0 | 0 | 83.0 | 85 | 57 | 57 | 17 | 37 | 79 | 3 | 2 | 3 | 1.47 | 9.22 | 1.84 | 4.01 | 8.57 | 6.18 | 2.14 | 2014- 5- 162-OAK | premium | premium | premium | MLB | 2018-2019 | 2013-2022 | 2021 |
| 39 | Kevin Herget | 30 | R | 7 | 5 | 4.48 | 28 | 7 | 0 | 0 | 21 | 8 | 2 | 80.1 | 82 | 49 | 40 | 18 | 23 | 85 | 0 | 0 | 4 | 1.31 | 9.19 | 2.02 | 2.58 | 9.52 | 5.49 | 3.70 | 2013- 39-1175-SLN | premium | premium | premium | MLB | 2022-2025 | 2013-2025 | 2021 |
| 34 | Matt Koch | 30 | R | 4 | 2 | 5.83 | 34 | 4 | 0 | 0 | 30 | 3 | 0 | 63.1 | 62 | 42 | 41 | 11 | 29 | 52 | 6 | 0 | 5 | 1.44 | 8.81 | 1.56 | 4.12 | 7.39 | 5.97 | 1.79 | 2012- 3- 107-NYN | premium | premium | premium | MLB | 2016-2024 | 2010-2024 | 2021 |
| 17 | Kyle Dowdy | 28 | R | 4 | 4 | 4.80 | 39 | 0 | 0 | 0 | 39 | 12 | 1 | 60.0 | 55 | 41 | 32 | 9 | 40 | 63 | 6 | 0 | 3 | 1.58 | 8.25 | 1.35 | 6.00 | 9.45 | 6.15 | 1.58 | 2015- 12- 370-DET | premium | premium | premium | MLB | 2019-2022 | 2012-2023 | 2021 |
| 46 | Manuel Alvarez | 25 | R | 0 | 2 | 16.20 | 8 | 1 | 0 | 0 | 7 | 1 | 0 | 6.2 | 7 | 15 | 12 | 0 | 14 | 8 | 3 | 0 | 5 | 3.15 | 9.45 | 0.00 | 18.90 | 10.80 | 20.25 | 0.57 | 2017- UDFA -CLE | premium | premium | premium | AAA | 2018-2025 | 2021 | |
| 28 | James Karinchak | 25 | R | 1 | 1 | 3.00 | 7 | 0 | 0 | 0 | 7 | 2 | 0 | 6.0 | 3 | 2 | 2 | 1 | 3 | 9 | 1 | 0 | 0 | 1.00 | 4.50 | 1.50 | 4.50 | 13.50 | 3.00 | 3.00 | 2017- 9- 282-CLE | premium | premium | premium | MLB | 2019-2023 | 2015-2025 | 2021 |
| 41 | Danny Young | 27 | L | 2 | 2 | 4.47 | 40 | 0 | 0 | 0 | 40 | 12 | 0 | 52.1 | 52 | 30 | 26 | 9 | 26 | 58 | 4 | 1 | 4 | 1.49 | 8.94 | 1.55 | 4.47 | 9.97 | 5.16 | 2.23 | 2015- 8- 242-TOR | premium | premium | premium | MLB | 2022-2025 | 2013-2025 | 2021 |
| 23 | Robert Broom | 24 | R | 2 | 3 | 5.29 | 45 | 3 | 0 | 0 | 42 | 15 | 2 | 49.1 | 45 | 29 | 29 | 9 | 23 | 52 | 2 | 0 | 14 | 1.38 | 8.21 | 1.64 | 4.20 | 9.49 | 5.29 | 2.26 | 2018- 10- 313-CLE | premium | premium | premium | AAA | 2016-2022 | 2021 | |
| 22 | Logan Allen | 24 | L | 2 | 3 | 7.95 | 12 | 11 | 0 | 0 | 1 | 1 | 0 | 48.2 | 61 | 43 | 43 | 9 | 29 | 52 | 5 | 0 | 4 | 1.85 | 11.28 | 1.66 | 5.36 | 9.62 | 7.95 | 1.79 | 2015- 8- 231-BOS | premium | premium | premium | MLB | 2019-2024 | 2015-2024 | 2021 |
| 43 | Jordan Stephens | 28 | R | 3 | 0 | 4.72 | 37 | 0 | 0 | 0 | 37 | 17 | 6 | 47.2 | 55 | 30 | 25 | 10 | 20 | 48 | 1 | 0 | 3 | 1.57 | 10.38 | 1.89 | 3.78 | 9.06 | 5.66 | 2.40 | 2015- 5- 142-CHA | premium | premium | premium | AAA | 2012-2022 | 2021 | |
| 48 | Zach Draper | 26 | L | 0 | 0 | 8.31 | 4 | 0 | 0 | 0 | 4 | 2 | 0 | 4.1 | 6 | 4 | 4 | 1 | 4 | 4 | 1 | 0 | 0 | 2.31 | 12.46 | 2.08 | 8.31 | 8.31 | 8.31 | 1.00 | 2017- 30- 912-CLE | premium | premium | premium | AAA | 2014-2022 | 2021 | |
| 49 | Sam Hentges | 24 | L | 0 | 0 | 6.23 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 4.1 | 1 | 3 | 3 | 0 | 2 | 6 | 1 | 0 | 1 | 0.69 | 2.08 | 0.00 | 4.15 | 12.46 | 6.23 | 3.00 | 2014- 4- 128-CLE | premium | premium | premium | MLB | 2021-2024 | 2014-2024 | 2021 |
| 51 | Tanner Tully | 26 | L | 0 | 3 | 5.08 | 9 | 6 | 0 | 0 | 3 | 0 | 0 | 39.0 | 42 | 23 | 22 | 4 | 14 | 33 | 2 | 0 | 0 | 1.44 | 9.69 | 0.92 | 3.23 | 7.62 | 5.31 | 2.36 | 2016- 26- 782-CLE | premium | premium | premium | MLB | 2022-2022 | 2014-2025 | 2021 |
| 35 | Cody Morris | 24 | R | 2 | 2 | 1.72 | 9 | 8 | 0 | 0 | 1 | 1 | 0 | 36.2 | 25 | 11 | 7 | 1 | 12 | 52 | 1 | 1 | 0 | 1.01 | 6.14 | 0.25 | 2.95 | 12.76 | 2.70 | 4.33 | 2018- 7- 223-CLE | premium | premium | premium | MLB | 2022-2023 | 2017-2024 | 2021 |
| 44 | Brad Peacock | 33 | R | 0 | 4 | 7.68 | 11 | 10 | 0 | 0 | 1 | 0 | 0 | 34.0 | 39 | 30 | 29 | 6 | 14 | 38 | 0 | 0 | 5 | 1.56 | 10.32 | 1.59 | 3.71 | 10.06 | 7.94 | 2.71 | 2006- 41-1231-WAS | premium | premium | premium | MLB | 2011-2021 | 2007-2022 | 2021 |
| 27 | Anthony Gose | 30 | L | 6 | 1 | 3.55 | 28 | 1 | 0 | 0 | 27 | 7 | 2 | 33.0 | 20 | 14 | 13 | 4 | 28 | 49 | 1 | 0 | 0 | 1.45 | 5.45 | 1.09 | 7.64 | 13.36 | 3.82 | 1.75 | 2008- 2- 51-PHI | premium | premium | premium | MLB | 2012-2024 | 2008-2025 | 2021 |
| 46 | Angel Lopez | 24 | R | 0 | 0 | 3.00 | 3 | 0 | 0 | 0 | 3 | 3 | 0 | 3.0 | 4 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 2.00 | 12.00 | 0.00 | 6.00 | 3.00 | 3.00 | 0.50 | 2017- 13- 402-CLE | premium | premium | premium | AAA | 2017-2022 | 2021 | |
| 48 | Francisco Perez | 23 | L | 1 | 0 | 3.12 | 19 | 0 | 0 | 0 | 19 | 5 | 1 | 26.0 | 20 | 9 | 9 | 2 | 20 | 36 | 3 | 0 | 2 | 1.54 | 6.92 | 0.69 | 6.92 | 12.46 | 3.12 | 1.80 | 2014- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2015-2024 | 2021 |
| 26 | Kyle Nelson | 24 | L | 0 | 1 | 6.66 | 25 | 0 | 0 | 0 | 25 | 2 | 1 | 25.2 | 23 | 22 | 19 | 1 | 20 | 30 | 1 | 0 | 0 | 1.68 | 8.06 | 0.35 | 7.01 | 10.52 | 7.71 | 1.50 | 2017- 15- 462-CLE | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 40 | J.C. Mejia | 24 | R | 1 | 3 | 6.75 | 10 | 6 | 0 | 0 | 4 | 0 | 0 | 25.1 | 24 | 19 | 19 | 8 | 16 | 27 | 2 | 0 | 3 | 1.58 | 8.53 | 2.84 | 5.68 | 9.59 | 6.75 | 1.69 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2021-2023 | 2014-2025 | 2021 |
| 65 | Cam Hill | 27 | R | 1 | 1 | 8.03 | 24 | 1 | 0 | 0 | 23 | 1 | 0 | 24.2 | 33 | 22 | 22 | 3 | 16 | 18 | 2 | 0 | 6 | 1.99 | 12.04 | 1.09 | 5.84 | 6.57 | 8.03 | 1.13 | 2014- 17- 518-CLE | premium | premium | premium | MLB | 2020-2020 | 2013-2024 | 2021 |
| 50 | Zack Godley | 31 | R | 1 | 2 | 6.00 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 24.0 | 30 | 19 | 16 | 5 | 11 | 18 | 3 | 0 | 4 | 1.71 | 11.25 | 1.88 | 4.13 | 6.75 | 7.13 | 1.64 | 2013- 10- 288-CHN | premium | premium | premium | MLB | 2015-2021 | 2011-2023 | 2021 |
| 32 | Justin Garza | 27 | R | 1 | 1 | 1.59 | 14 | 0 | 0 | 0 | 14 | 3 | 1 | 22.2 | 8 | 5 | 4 | 2 | 13 | 31 | 1 | 0 | 0 | 0.93 | 3.18 | 0.79 | 5.16 | 12.31 | 1.99 | 2.38 | 2015- 8- 244-CLE | premium | premium | premium | MLB | 2021-2025 | 2013-2025 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 29 | Eli Morgan | 25 | R | 0 | 1 | 4.03 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 22.1 | 20 | 10 | 10 | 1 | 11 | 21 | 1 | 1 | 1 | 1.39 | 8.06 | 0.40 | 4.43 | 8.46 | 4.03 | 1.91 | 2017- 8- 252-CLE | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 45 | Dalbert Siri | 25 | R | 2 | 1 | 7.06 | 15 | 0 | 0 | 0 | 15 | 0 | 0 | 21.2 | 23 | 17 | 17 | 5 | 9 | 23 | 3 | 1 | 5 | 1.48 | 9.55 | 2.08 | 3.74 | 9.55 | 7.06 | 2.56 | 2014- UDFA -CLE | premium | premium | premium | AAA | 2015-2021 | 2021 | |
| 35 | DJ Johnson | 31 | R | 1 | 2 | 3.32 | 21 | 0 | 0 | 0 | 21 | 15 | 6 | 21.2 | 24 | 10 | 8 | 3 | 11 | 35 | 4 | 0 | 2 | 1.62 | 9.97 | 1.25 | 4.57 | 14.54 | 4.15 | 3.18 | 2010- UDFA -TBA | premium | premium | premium | MLB | 2018-2021 | 2010-2025 | 2021 |
| 40 | Triston McKenzie | 23 | R | 1 | 1 | 2.95 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 21.1 | 18 | 8 | 7 | 5 | 12 | 23 | 0 | 0 | 0 | 1.41 | 7.59 | 2.11 | 5.06 | 9.70 | 3.38 | 1.92 | 2015- 1- 42-CLE | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 74 | Scott Moss | 26 | L | 1 | 5 | 7.08 | 9 | 7 | 0 | 0 | 2 | 0 | 0 | 20.1 | 20 | 16 | 16 | 2 | 15 | 29 | 0 | 0 | 1 | 1.72 | 8.85 | 0.89 | 6.64 | 12.84 | 7.08 | 1.93 | 2016- 4- 108-CIN | premium | premium | premium | AAA | 2016-2022 | 2021 | |
| 15 | Shane Bieber | 26 | R | 0 | 0 | 3.37 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2.2 | 3 | 1 | 1 | 0 | 1 | 3 | 0 | 0 | 0 | 1.50 | 10.12 | 0.00 | 3.37 | 10.12 | 3.37 | 3.00 | 2016- 4- 122-CLE | premium | premium | premium | MLB | 2018-2025 | 2014-2025 | 2021 |
| 30 | Juan Hillman | 24 | L | 0 | 0 | 11.57 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2.1 | 5 | 3 | 3 | 0 | 2 | 2 | 0 | 0 | 0 | 3.00 | 19.29 | 0.00 | 7.71 | 7.71 | 11.57 | 1.00 | 2015- 2- 59-CLE | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 29 | Nathan Ocker | 24 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 2.0 | 1 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 1.00 | 4.50 | 0.00 | 4.50 | 13.50 | 0.00 | 3.00 | 2019- 29- 880-CLE | premium | premium | premium | AAA | 2016-2022 | 2021 | |
| 49 | Juan Mota | 25 | R | 2 | 2 | 6.86 | 17 | 0 | 0 | 0 | 17 | 5 | 0 | 19.2 | 17 | 17 | 15 | 3 | 17 | 25 | 4 | 1 | 2 | 1.73 | 7.78 | 1.37 | 7.78 | 11.44 | 7.78 | 1.47 | 2015- UDFA -CLE | premium | premium | premium | AAA | 2016-2021 | 2021 | |
| 15 | Kirk McCarty | 25 | L | 9 | 6 | 5.01 | 24 | 24 | 0 | 0 | 0 | 0 | 0 | 124.0 | 117 | 73 | 69 | 25 | 44 | 104 | 2 | 0 | 3 | 1.30 | 8.49 | 1.81 | 3.19 | 7.55 | 5.30 | 2.36 | 2017- 7- 222-CLE | premium | premium | premium | MLB | 2022-2022 | 2015-2022 | 2021 |
| 40 | Adam Scott | 25 | L | 0 | 3 | 6.00 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 12.0 | 12 | 9 | 8 | 2 | 10 | 12 | 1 | 0 | 0 | 1.83 | 9.00 | 1.50 | 7.50 | 9.00 | 6.75 | 1.20 | 2018- 4- 133-CLE | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 38 | Blake Parker | 36 | R | 0 | 0 | 0.00 | 12 | 0 | 0 | 0 | 12 | 8 | 4 | 11.0 | 2 | 0 | 0 | 0 | 5 | 15 | 1 | 0 | 0 | 0.64 | 1.64 | 0.00 | 4.09 | 12.27 | 0.00 | 3.00 | 2006- 16- 479-CHN | premium | premium | premium | MLB | 2012-2021 | 2004-2022 | 2021 |
| Totals: | 59 | 68 | 5.22 | 563 | 127 | 0 | 0 | 127 | 436 | 26 | 1099.0 | 1059 | 692 | 637 | 177 | 563 | 1160 | 68 | 7 | 81 | 1.48 | 8.67 | 1.45 | 4.61 | 9.50 | 5.67 | 2.06 | premium | premium | premium |