| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 23 | Mason Martin | 22 | 1B | L | 106 | 112 | 414 | 62 | 100 | 29 | 2 | 22 | 75 | 0 | 2 | 38 | 161 | 12 | 0 | 7 | 2 | 3 | 199 | 471 | 53 | 47 | .242 | .318 | .481 | .799 | .326 | .239 | .328 | 8.07 | 34.18 | 4.24 | 18.82 | 2017- 17- 508-PIT | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 5 | Cal Mitchell | 22 | RF | L | 101 | 108 | 382 | 43 | 107 | 19 | 1 | 12 | 61 | 6 | 7 | 24 | 71 | 7 | 0 | 5 | 1 | 6 | 164 | 418 | 32 | 75 | .280 | .330 | .429 | .759 | .209 | .149 | .313 | 5.74 | 16.99 | 2.96 | 31.83 | 2017- 2- 50-PIT | premium | premium | premium | MLB | 2022-2023 | 2017-2025 | 2021 |
| 2 | Ji Hwan Bae | 21 | 2B | L | 106 | 83 | 320 | 63 | 89 | 12 | 5 | 7 | 31 | 20 | 8 | 38 | 83 | 4 | 0 | 3 | 0 | 3 | 132 | 365 | 24 | 65 | .278 | .359 | .413 | .772 | .291 | .135 | .352 | 10.41 | 22.74 | 2.18 | 45.71 | 2018- UDFA -PIT | premium | premium | premium | MLB | 2022-2025 | 2018-2025 | 2021 |
| 32 | Rodolfo Castro | 22 | 3B-2B | R | 96 | 72 | 285 | 43 | 69 | 14 | 1 | 12 | 47 | 7 | 4 | 19 | 72 | 4 | 0 | 4 | 1 | 6 | 121 | 312 | 27 | 42 | .242 | .295 | .425 | .720 | .260 | .183 | .278 | 6.09 | 23.08 | 3.79 | 23.75 | 2015- UDFA -PIT | premium | premium | premium | MLB | 2021-2023 | 2016-2025 | 2021 |
| 13 | Oneil Cruz | 22 | SS | L | 120 | 62 | 250 | 51 | 73 | 15 | 5 | 12 | 40 | 18 | 3 | 20 | 64 | 1 | 0 | 1 | 0 | 3 | 134 | 272 | 32 | 41 | .292 | .346 | .536 | .882 | .384 | .244 | .349 | 7.35 | 23.53 | 3.20 | 20.83 | 2015- UDFA -LAN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 12 | Josh Bissonette | 24 | 3B | R | 83 | 71 | 231 | 28 | 53 | 10 | 0 | 1 | 21 | 1 | 1 | 24 | 51 | 1 | 1 | 2 | 0 | 8 | 66 | 259 | 11 | 42 | .229 | .302 | .286 | .588 | .160 | .057 | .287 | 9.27 | 19.69 | 2.13 | 231.00 | 2019- 31- 934-PIT | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 6 | Daniel Amaral | 24 | CF-LF | R | 93 | 68 | 220 | 32 | 48 | 12 | 0 | 7 | 22 | 9 | 4 | 24 | 62 | 3 | 0 | 1 | 0 | 7 | 81 | 248 | 19 | 29 | .218 | .302 | .368 | .670 | .282 | .150 | .270 | 9.68 | 25.00 | 2.58 | 31.43 | 2018- 14- 414-PIT | premium | premium | premium | AA | 2016-2025 | 2021 | |
| 24 | Canaan Smith-Njigba | 22 | LF | L | 114 | 66 | 219 | 35 | 60 | 11 | 0 | 6 | 40 | 13 | 1 | 45 | 66 | 1 | 0 | 1 | 1 | 5 | 89 | 266 | 17 | 43 | .274 | .398 | .406 | .804 | .393 | .132 | .365 | 16.92 | 24.81 | 1.47 | 36.50 | 2017- 4- 122-NYA | premium | premium | premium | MLB | 2022-2023 | 2017-2024 | 2021 |
| 36 | Arden Pabst | 26 | C | R | 74 | 61 | 206 | 21 | 40 | 7 | 0 | 7 | 28 | 0 | 0 | 7 | 73 | 0 | 0 | 1 | 0 | 0 | 68 | 214 | 14 | 26 | .194 | .220 | .330 | .550 | .170 | .136 | .260 | 3.27 | 34.11 | 10.43 | 29.43 | 2016- 12- 375-PIT | premium | premium | premium | AAA | 2014-2023 | 2021 | |
| 14 | Jonah Davis | 23 | CF | L | 98 | 60 | 190 | 29 | 40 | 7 | 3 | 8 | 19 | 4 | 6 | 26 | 95 | 5 | 0 | 0 | 0 | 2 | 77 | 221 | 18 | 22 | .211 | .321 | .405 | .726 | .321 | .194 | .368 | 11.76 | 42.99 | 3.65 | 23.75 | 2018- 15- 444-PIT | premium | premium | premium | AA | 2016-2024 | 2021 | |
| 10 | Brendt Citta | 24 | 1B | R | 103 | 47 | 160 | 16 | 47 | 9 | 2 | 2 | 23 | 0 | 1 | 10 | 36 | 3 | 0 | 0 | 1 | 9 | 66 | 173 | 13 | 34 | .294 | .347 | .413 | .760 | .175 | .119 | .369 | 5.78 | 20.81 | 3.60 | 80.00 | 2018- 38-1134-PIT | premium | premium | premium | AAA | 2016-2022 | 2021 | |
| 39 | Jack Suwinski | 22 | LF | L | 104 | 45 | 151 | 21 | 38 | 9 | 0 | 4 | 21 | 4 | 2 | 25 | 51 | 2 | 1 | 3 | 0 | 2 | 59 | 182 | 13 | 25 | .252 | .359 | .391 | .750 | .318 | .139 | .343 | 13.74 | 28.02 | 2.04 | 37.75 | 2016- 15- 444-SDN | premium | premium | premium | MLB | 2022-2025 | 2016-2025 | 2021 |
| 52 | Connor Kaiser | 24 | SS | R | 84 | 48 | 149 | 25 | 29 | 7 | 0 | 4 | 14 | 0 | 0 | 17 | 42 | 1 | 0 | 1 | 0 | 1 | 48 | 168 | 11 | 18 | .195 | .280 | .322 | .602 | .242 | .127 | .240 | 10.12 | 25.00 | 2.47 | 37.25 | 2018- 3- 86-PIT | premium | premium | premium | MLB | 2023-2025 | 2016-2025 | 2021 |
| 14 | Matt Fraizer | 23 | CF | L | 112 | 37 | 132 | 20 | 38 | 12 | 3 | 3 | 18 | 1 | 2 | 13 | 34 | 2 | 0 | 2 | 0 | 3 | 65 | 149 | 18 | 20 | .288 | .356 | .492 | .848 | .295 | .204 | .361 | 8.72 | 22.82 | 2.62 | 44.00 | 2019- 3- 95-PIT | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 32 | Diego Castillo | 23 | SS-2B | R | 111 | 28 | 110 | 11 | 31 | 3 | 0 | 5 | 16 | 1 | 2 | 10 | 9 | 0 | 1 | 0 | 1 | 2 | 49 | 121 | 8 | 23 | .282 | .342 | .445 | .787 | .245 | .163 | .271 | 8.26 | 7.44 | 0.90 | 22.00 | 2014- UDFA -NYA | premium | premium | premium | MLB | 2022-2024 | 2015-2025 | 2021 |
| 38 | Jason Delay | 26 | C | R | 17 | 60 | 1 | 7 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 23 | 0 | 0 | 0 | 0 | 2 | 9 | 60 | 2 | 5 | .117 | .117 | .150 | .267 | .033 | .033 | .189 | 0.00 | 38.33 | 0.00 | 0.00 | 2017- 4- 118-PIT | premium | premium | premium | MLB | 2022-2024 | 2014-2025 | 2021 | |
| 7 | Carter Bins | 22 | C | R | 16 | 55 | 4 | 11 | 2 | 0 | 0 | 6 | 0 | 0 | 10 | 19 | 1 | 0 | 0 | 0 | 0 | 13 | 66 | 2 | 9 | .200 | .333 | .236 | .569 | .218 | .036 | .306 | 15.15 | 28.79 | 1.90 | 0.00 | 2019- 11- 336-SEA | premium | premium | premium | AAA | 2017-2024 | 2021 | ||
| 48 | Grant Koch | 24 | C | R | 16 | 54 | 4 | 7 | 2 | 0 | 1 | 4 | 0 | 0 | 2 | 13 | 0 | 0 | 0 | 0 | 0 | 12 | 56 | 3 | 4 | .130 | .161 | .222 | .383 | .130 | .092 | .150 | 3.57 | 23.21 | 6.50 | 54.00 | 2018- 5- 144-PIT | premium | premium | premium | MLB | 2024-2024 | 2016-2024 | 2021 | |
| 7 | Jesus Valdez | 23 | 3B | R | 13 | 41 | 3 | 7 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 13 | 0 | 0 | 0 | 0 | 0 | 10 | 42 | 1 | 6 | .171 | .190 | .244 | .434 | .098 | .073 | .222 | 2.38 | 30.95 | 13.00 | 41.00 | 2017- UDFA -LAN | premium | premium | premium | AAA | 2018-2025 | 2021 | ||
| 19 | Raul Hernandez | 25 | C | R | 10 | 35 | 4 | 8 | 1 | 0 | 1 | 4 | 0 | 0 | 1 | 9 | 0 | 0 | 0 | 0 | 2 | 12 | 36 | 2 | 6 | .229 | .250 | .343 | .593 | .143 | .114 | .280 | 2.78 | 25.00 | 9.00 | 35.00 | 2014- UDFA -PIT | premium | premium | premium | AA | 2015-2021 | 2021 | ||
| 37 | Deon Stafford | 25 | LF-RF | R | 14 | 31 | 5 | 5 | 1 | 0 | 2 | 3 | 0 | 0 | 2 | 11 | 0 | 0 | 0 | 0 | 0 | 12 | 33 | 3 | 2 | .161 | .212 | .387 | .599 | .290 | .226 | .167 | 6.06 | 33.33 | 5.50 | 15.50 | 2017- 5- 148-PIT | premium | premium | premium | AA | 2015-2022 | 2021 | ||
| 7 | Bligh Madris | 25 | RF-LF | L | 10 | 26 | 2 | 5 | 0 | 0 | 0 | 1 | 0 | 0 | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 5 | 33 | 0 | 5 | .192 | .364 | .192 | .556 | .269 | .000 | .250 | 21.21 | 18.18 | 0.86 | 0.00 | 2017- 9- 268-PIT | premium | premium | premium | MLB | 2022-2024 | 2015-2025 | 2021 | |
| 32 | Chase Murray | 23 | LF | L | 9 | 25 | 1 | 8 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 9 | 26 | 1 | 7 | .320 | .346 | .360 | .706 | .080 | .040 | .421 | 3.85 | 23.08 | 6.00 | 0.00 | 2019- 13- 394-PIT | premium | premium | premium | AA | 2017-2021 | 2021 | ||
| 37 | Ethan Paul | 24 | 2B | L | 8 | 23 | 4 | 5 | 1 | 0 | 0 | 1 | 2 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 6 | 27 | 1 | 4 | .217 | .333 | .261 | .594 | .304 | .044 | .313 | 14.81 | 25.93 | 1.75 | 0.00 | 2019- 9- 274-PIT | premium | premium | premium | AAA | 2016-2021 | 2021 | ||
| 76 | Dylan Busby | 25 | 3B-1B | R | 3 | 11 | 3 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 1 | 5 | 12 | 1 | 1 | .182 | .250 | .455 | .705 | .364 | .273 | .143 | 8.33 | 25.00 | 3.00 | 11.00 | 2017- 3- 88-PIT | premium | premium | premium | AAA | 2015-2022 | 2021 | ||
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| - | Joe Jimenez | 23 | C | R | 2 | 6 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 8 | 1 | 0 | .167 | .375 | .667 | 1.042 | .833 | .500 | .000 | 25.00 | 12.50 | 0.50 | 6.00 | 2020- UDFA -PIT | premium | premium | premium | AA | 2017-2021 | 2021 | ||
| 25 | Jeffrey Passantino | 25 | P | R | 3 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2 | 4 | 0 | 2 | .500 | .500 | .500 | 1.000 | .000 | .000 | .667 | 0.00 | 25.00 | 0.00 | 0.00 | 2017- 40-1215-CHN | premium | premium | premium | AAA | 2015-2022 | 2021 | ||
| 44 | Osvaldo Bido | 25 | P | R | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2017- UDFA -PIT | premium | premium | premium | MLB | 2023-2025 | 2017-2025 | 2021 | |
| 50 | Roansy Contreras | 21 | P | R | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2016- UDFA -NYA | premium | premium | premium | MLB | 2021-2025 | 2017-2025 | 2021 | |
| 15 | Travis MacGregor | 23 | P | R | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2016- 2- 68-PIT | premium | premium | premium | AAA | 2016-2025 | 2021 | ||
| 30 | Noe Toribio | 21 | P | R | 2 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 1 | .250 | .250 | .250 | .500 | .000 | .000 | .333 | 0.00 | 25.00 | 0.00 | 0.00 | 2016- UDFA -PIT | premium | premium | premium | AAA | 2017-2024 | 2021 | ||
| 19 | Cam Vieaux | 27 | P | L | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2016- 6- 195-PIT | premium | premium | premium | MLB | 2022-2022 | 2014-2025 | 2021 | |
| - | Claudio Finol | 21 | 3B | R | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2016- UDFA -CIN | premium | premium | premium | AA | 2017-2025 | 2021 | ||
| 38 | Max Kranick | 23 | P | R | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | .500 | .500 | .500 | 1.000 | .000 | .000 | 1.000 | 0.00 | 50.00 | 0.00 | 0.00 | 2016- 11- 345-PIT | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 | |
| 47 | Oddy Nunez | 24 | P | L | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2015- UDFA -PIT | premium | premium | premium | AA | 2015-2025 | 2021 | ||
| 77 | John O'Reilly | 25 | P | R | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2018- UDFA -PIT | premium | premium | premium | AAA | 2015-2024 | 2021 | ||
| 28 | Cam Alldred | 24 | P | L | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2018- 24- 714-PIT | premium | premium | premium | MLB | 2022-2022 | 2016-2025 | 2021 | |
| 43 | Brad Case | 24 | P | R | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2018- 17- 504-PIT | premium | premium | premium | AAA | 2018-2025 | 2021 | ||
| 3 | Trey McGough | 23 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2019- 24- 724-PIT | premium | premium | premium | AAA | 2017-2025 | 2021 | ||
| 34 | Will Gardner | 25 | P | R | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2018- 21- 624-PIT | premium | premium | premium | AA | 2015-2021 | 2021 | ||
| Totals: | 1123 | 3820 | 535 | 932 | 186 | 22 | 119 | 504 | 86 | 43 | 371 | 1102 | 47 | 6 | 31 | 7 | 66 | 1519 | 4275 | 327 | 605 | .244 | .316 | .398 | .714 | .262 | .154 | .309 | 8.68 | 25.78 | 2.97 | 32.10 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 3 | Trey McGough | 23 | L | 6 | 5 | 3.41 | 18 | 18 | 1 | 0 | 0 | 0 | 0 | 95.0 | 89 | 39 | 36 | 7 | 21 | 77 | 4 | 0 | 1 | 1.16 | 8.43 | 0.66 | 1.99 | 7.29 | 3.69 | 3.67 | 2019- 24- 724-PIT | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 44 | Osvaldo Bido | 25 | R | 4 | 8 | 5.09 | 21 | 19 | 0 | 0 | 2 | 0 | 0 | 93.2 | 95 | 61 | 53 | 13 | 33 | 91 | 5 | 2 | 8 | 1.37 | 9.13 | 1.25 | 3.17 | 8.74 | 5.86 | 2.76 | 2017- UDFA -PIT | premium | premium | premium | MLB | 2023-2025 | 2017-2025 | 2021 |
| 15 | Travis MacGregor | 23 | R | 4 | 9 | 6.25 | 22 | 21 | 0 | 0 | 1 | 0 | 0 | 90.2 | 92 | 69 | 63 | 13 | 41 | 88 | 10 | 0 | 10 | 1.47 | 9.13 | 1.29 | 4.07 | 8.74 | 6.85 | 2.15 | 2016- 2- 68-PIT | premium | premium | premium | AAA | 2016-2025 | 2021 | |
| 25 | Jeffrey Passantino | 25 | R | 1 | 8 | 4.62 | 18 | 15 | 0 | 0 | 3 | 1 | 1 | 76.0 | 77 | 41 | 39 | 12 | 20 | 74 | 1 | 0 | 2 | 1.28 | 9.12 | 1.42 | 2.37 | 8.76 | 4.86 | 3.70 | 2017- 40-1215-CHN | premium | premium | premium | AAA | 2015-2022 | 2021 | |
| 31 | Omar Cruz | 22 | L | 3 | 4 | 3.44 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 70.2 | 70 | 32 | 27 | 6 | 22 | 60 | 5 | 0 | 6 | 1.30 | 8.92 | 0.76 | 2.80 | 7.64 | 4.08 | 2.73 | 2017- UDFA -SDN | premium | premium | premium | MLB | 2025-2025 | 2018-2025 | 2021 |
| 43 | Brad Case | 24 | R | 2 | 3 | 5.24 | 28 | 2 | 0 | 0 | 26 | 4 | 0 | 67.0 | 80 | 41 | 39 | 13 | 21 | 57 | 3 | 0 | 4 | 1.51 | 10.75 | 1.75 | 2.82 | 7.66 | 5.51 | 2.71 | 2018- 17- 504-PIT | premium | premium | premium | AAA | 2018-2025 | 2021 | |
| 50 | Roansy Contreras | 21 | R | 3 | 2 | 2.65 | 12 | 12 | 0 | 0 | 0 | 0 | 0 | 54.1 | 37 | 21 | 16 | 5 | 12 | 76 | 1 | 0 | 3 | 0.90 | 6.13 | 0.83 | 1.99 | 12.59 | 3.48 | 6.33 | 2016- UDFA -NYA | premium | premium | premium | MLB | 2021-2025 | 2017-2025 | 2021 |
| 28 | Cam Alldred | 24 | L | 4 | 0 | 2.53 | 28 | 0 | 0 | 0 | 28 | 5 | 1 | 53.1 | 33 | 17 | 15 | 5 | 23 | 49 | 3 | 0 | 5 | 1.05 | 5.57 | 0.84 | 3.88 | 8.27 | 2.87 | 2.13 | 2018- 24- 714-PIT | premium | premium | premium | MLB | 2022-2022 | 2016-2025 | 2021 |
| 30 | Noe Toribio | 21 | R | 2 | 2 | 4.32 | 14 | 8 | 0 | 0 | 6 | 1 | 0 | 50.0 | 46 | 29 | 24 | 5 | 13 | 40 | 3 | 0 | 7 | 1.18 | 8.28 | 0.90 | 2.34 | 7.20 | 5.22 | 3.08 | 2016- UDFA -PIT | premium | premium | premium | AAA | 2017-2024 | 2021 | |
| 47 | Oddy Nunez | 24 | L | 2 | 1 | 8.32 | 28 | 0 | 0 | 0 | 28 | 4 | 1 | 44.1 | 48 | 43 | 41 | 5 | 37 | 51 | 11 | 0 | 11 | 1.92 | 9.74 | 1.02 | 7.51 | 10.35 | 8.73 | 1.38 | 2015- UDFA -PIT | premium | premium | premium | AA | 2015-2025 | 2021 | |
| 19 | Cam Vieaux | 27 | L | 5 | 1 | 3.68 | 17 | 5 | 0 | 0 | 12 | 0 | 0 | 44.0 | 35 | 21 | 18 | 5 | 16 | 44 | 4 | 0 | 3 | 1.16 | 7.16 | 1.02 | 3.27 | 9.00 | 4.30 | 2.75 | 2016- 6- 195-PIT | premium | premium | premium | MLB | 2022-2022 | 2014-2025 | 2021 |
| 17 | Shea Murray | 27 | R | 4 | 3 | 4.12 | 37 | 0 | 0 | 0 | 37 | 18 | 4 | 43.2 | 41 | 25 | 20 | 3 | 38 | 51 | 8 | 0 | 8 | 1.81 | 8.45 | 0.62 | 7.83 | 10.51 | 5.15 | 1.34 | 2017- 18- 538-PIT | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 34 | Will Gardner | 25 | R | 2 | 5 | 7.71 | 33 | 0 | 0 | 0 | 33 | 15 | 0 | 42.0 | 38 | 39 | 36 | 7 | 29 | 43 | 4 | 1 | 5 | 1.60 | 8.14 | 1.50 | 6.21 | 9.21 | 8.36 | 1.48 | 2018- 21- 624-PIT | premium | premium | premium | AA | 2015-2021 | 2021 | |
| - | Alex Manasa | 23 | R | 0 | 0 | 15.75 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 4.0 | 15 | 10 | 7 | 2 | 0 | 1 | 0 | 0 | 0 | 3.75 | 33.75 | 4.50 | 0.00 | 2.25 | 22.50 | 0.00 | 2017- 11- 328-PIT | premium | premium | premium | AAA | 2017-2022 | 2021 | |
| 77 | John O'Reilly | 25 | R | 3 | 3 | 5.09 | 22 | 0 | 0 | 0 | 22 | 13 | 3 | 35.1 | 47 | 24 | 20 | 1 | 8 | 22 | 2 | 0 | 1 | 1.56 | 11.97 | 0.25 | 2.04 | 5.60 | 6.11 | 2.75 | 2018- UDFA -PIT | premium | premium | premium | AAA | 2015-2024 | 2021 | |
| 26 | Cristofer Melendez | 23 | R | 3 | 3 | 4.41 | 28 | 0 | 0 | 0 | 28 | 23 | 7 | 32.2 | 21 | 21 | 16 | 2 | 18 | 39 | 7 | 0 | 4 | 1.19 | 5.79 | 0.55 | 4.96 | 10.74 | 5.79 | 2.17 | 2014- UDFA -HOU | premium | premium | premium | AAA | 2015-2025 | 2021 | |
| 46 | Steven Jennings | 22 | R | 3 | 0 | 6.67 | 13 | 0 | 0 | 0 | 13 | 2 | 0 | 29.2 | 40 | 23 | 22 | 4 | 11 | 20 | 0 | 1 | 1 | 1.72 | 12.13 | 1.21 | 3.34 | 6.07 | 6.98 | 1.82 | 2017- 2- 42-PIT | premium | premium | premium | AAA | 2017-2025 | 2021 | |
| 53 | Hunter Stratton | 24 | R | 2 | 0 | 1.42 | 20 | 0 | 0 | 0 | 20 | 17 | 7 | 25.1 | 16 | 4 | 4 | 1 | 13 | 44 | 3 | 0 | 1 | 1.14 | 5.68 | 0.36 | 4.62 | 15.63 | 1.42 | 3.38 | 2017- 16- 478-PIT | premium | premium | premium | MLB | 2023-2025 | 2017-2025 | 2021 |
| 37 | Nathan Kirby | 27 | L | 1 | 0 | 6.52 | 17 | 0 | 0 | 0 | 17 | 4 | 1 | 19.1 | 19 | 18 | 14 | 1 | 15 | 37 | 1 | 0 | 2 | 1.76 | 8.84 | 0.47 | 6.98 | 17.22 | 8.38 | 2.47 | 2015- 1- 40-MIL | premium | premium | premium | AAA | 2013-2022 | 2021 | |
| 49 | Yerry De los Santos | 23 | R | 3 | 2 | 2.04 | 12 | 0 | 0 | 0 | 12 | 8 | 2 | 17.2 | 11 | 6 | 4 | 2 | 6 | 19 | 1 | 0 | 4 | 0.96 | 5.60 | 1.02 | 3.06 | 9.68 | 3.06 | 3.17 | 2014- UDFA -PIT | premium | premium | premium | MLB | 2022-2025 | 2015-2025 | 2021 |
| 38 | Max Kranick | 23 | R | 1 | 0 | 4.02 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 15.2 | 14 | 7 | 7 | 2 | 2 | 16 | 0 | 0 | 0 | 1.02 | 8.04 | 1.15 | 1.15 | 9.19 | 4.02 | 8.00 | 2016- 11- 345-PIT | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 36 | Arden Pabst | 26 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2016- 12- 375-PIT | premium | premium | premium | AAA | 2014-2023 | 2021 | |
| Totals: | 58 | 59 | 4.67 | 408 | 117 | 1 | 0 | 116 | 291 | 27 | 1004.2 | 964 | 591 | 521 | 114 | 399 | 999 | 76 | 4 | 86 | 1.36 | 8.64 | 1.02 | 3.57 | 8.95 | 5.29 | 2.50 | premium | premium | premium |