| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 27 | Jose Altuve | 31 | 2B | R | 113 | 146 | 601 | 117 | 167 | 32 | 1 | 31 | 83 | 5 | 3 | 66 | 91 | 4 | 1 | 6 | 3 | 9 | 294 | 678 | 64 | 103 | .278 | .350 | .489 | .839 | .324 | .211 | .280 | 9.73 | 13.42 | 1.38 | 19.39 | 2007- UDFA -HOU | premium | premium | premium | MLB | 2011-2025 | 2008-2025 | 2021 |
| 1 | Carlos Correa | 26 | SS | R | 115 | 148 | 555 | 104 | 155 | 34 | 1 | 26 | 92 | 0 | 0 | 75 | 116 | 4 | 0 | 6 | 2 | 16 | 269 | 640 | 61 | 94 | .279 | .366 | .485 | .851 | .341 | .206 | .308 | 11.72 | 18.13 | 1.55 | 21.35 | 2012- 1- 1-HOU | premium | premium | premium | MLB | 2015-2025 | 2012-2025 | 2021 |
| 44 | Yordan Alvarez | 24 | DH | L | 118 | 144 | 537 | 92 | 149 | 35 | 1 | 33 | 104 | 1 | 0 | 50 | 145 | 8 | 0 | 3 | 3 | 16 | 285 | 598 | 69 | 80 | .277 | .346 | .531 | .877 | .348 | .254 | .320 | 8.36 | 24.25 | 2.90 | 16.27 | 2016- UDFA -LAN | premium | premium | premium | MLB | 2019-2025 | 2016-2025 | 2021 |
| 10 | Yuli Gurriel | 37 | 1B | R | 115 | 143 | 530 | 83 | 169 | 31 | 0 | 15 | 81 | 1 | 1 | 59 | 68 | 4 | 0 | 12 | 2 | 16 | 245 | 605 | 46 | 123 | .319 | .383 | .462 | .845 | .255 | .143 | .336 | 9.75 | 11.24 | 1.15 | 35.33 | 2016- UDFA -HOU | premium | premium | premium | MLB | 2016-2025 | 2016-2025 | 2021 |
| 30 | Kyle Tucker | 24 | RF | L | 123 | 140 | 506 | 83 | 149 | 37 | 3 | 30 | 92 | 14 | 2 | 53 | 90 | 1 | 0 | 5 | 5 | 10 | 282 | 565 | 70 | 79 | .294 | .359 | .557 | .916 | .391 | .263 | .304 | 9.38 | 15.93 | 1.70 | 16.87 | 2015- 1- 5-HOU | premium | premium | premium | MLB | 2018-2025 | 2015-2025 | 2021 |
| 23 | Michael Brantley | 34 | LF | L | 110 | 121 | 469 | 68 | 146 | 29 | 3 | 8 | 47 | 1 | 0 | 33 | 53 | 5 | 0 | 1 | 1 | 11 | 205 | 508 | 40 | 106 | .311 | .362 | .437 | .799 | .198 | .126 | .337 | 6.50 | 10.43 | 1.61 | 58.63 | 2005- 7- 205-MIL | premium | premium | premium | MLB | 2009-2023 | 2005-2023 | 2021 |
| 15 | Martin Maldonado | 34 | C | R | 82 | 125 | 373 | 40 | 64 | 10 | 1 | 12 | 36 | 0 | 0 | 47 | 127 | 5 | 0 | 1 | 1 | 9 | 112 | 426 | 23 | 41 | .172 | .272 | .300 | .572 | .255 | .128 | .221 | 11.03 | 29.81 | 2.70 | 31.08 | 2004- 27- 803-ANA | premium | premium | premium | MLB | 2011-2025 | 2004-2025 | 2021 |
| 2 | Alex Bregman | 27 | 3B | R | 106 | 91 | 348 | 54 | 94 | 17 | 0 | 12 | 55 | 1 | 0 | 44 | 53 | 4 | 0 | 4 | 4 | 13 | 147 | 400 | 29 | 65 | .270 | .355 | .422 | .777 | .282 | .152 | .286 | 11.00 | 13.25 | 1.20 | 29.00 | 2015- 1- 2-HOU | premium | premium | premium | MLB | 2016-2025 | 2013-2025 | 2021 |
| 7 | Myles Straw | 26 | CF | R | 100 | 98 | 325 | 44 | 85 | 13 | 1 | 2 | 34 | 17 | 5 | 38 | 71 | 2 | 1 | 4 | 0 | 7 | 106 | 370 | 16 | 69 | .262 | .339 | .326 | .665 | .218 | .064 | .324 | 10.27 | 19.19 | 1.87 | 162.50 | 2015- 12- 349-HOU | premium | premium | premium | MLB | 2018-2025 | 2014-2025 | 2021 |
| 16 | Aledmys Diaz | 30 | 3B-LF | R | 98 | 84 | 294 | 28 | 76 | 19 | 0 | 8 | 45 | 0 | 1 | 16 | 62 | 9 | 0 | 0 | 3 | 7 | 119 | 319 | 27 | 49 | .259 | .317 | .405 | .722 | .197 | .146 | .304 | 5.02 | 19.44 | 3.88 | 36.75 | 2014- UDFA -SLN | premium | premium | premium | MLB | 2016-2024 | 2014-2025 | 2021 |
| 20 | Chas McCormick | 26 | LF-CF | R | 104 | 108 | 284 | 47 | 73 | 12 | 0 | 14 | 50 | 4 | 2 | 25 | 104 | 4 | 0 | 7 | 0 | 5 | 127 | 320 | 26 | 47 | .257 | .319 | .447 | .766 | .285 | .190 | .341 | 7.81 | 32.50 | 4.16 | 20.29 | 2017- 21- 631-HOU | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 18 | Jason Castro | 34 | C | L | 110* | 66 | 149 | 22 | 35 | 7 | 0 | 8 | 21 | 0 | 0 | 25 | 54 | 3 | 2 | 0 | 1 | 4 | 66 | 179 | 15 | 20 | .235 | .356 | .443 | .799 | .376 | .208 | .310 | 13.97 | 30.17 | 2.16 | 18.63 | 2008- 1- 10-HOU | premium | premium | premium | MLB | 2010-2022 | 2006-2022 | 2021 |
| 6 | Jake Meyers | 25 | CF | R | 105* | 49 | 146 | 22 | 38 | 8 | 0 | 6 | 28 | 3 | 0 | 10 | 50 | 4 | 2 | 1 | 0 | 0 | 64 | 163 | 14 | 24 | .260 | .323 | .438 | .761 | .267 | .178 | .352 | 6.13 | 30.67 | 5.00 | 24.33 | 2017- 13- 391-HOU | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 13 | Abraham Toro | 24 | 3B | B | 96 | 35 | 109 | 17 | 23 | 1 | 0 | 6 | 20 | 3 | 1 | 9 | 21 | 3 | 0 | 1 | 0 | 1 | 42 | 122 | 7 | 16 | .211 | .287 | .385 | .672 | .275 | .174 | .205 | 7.38 | 17.21 | 2.33 | 18.17 | 2016- 5- 157-HOU | premium | premium | premium | MLB | 2019-2025 | 2016-2025 | 2021 |
| 9 | Robel Garcia | 28 | 3B-SS | B | 61* | 46 | 106 | 8 | 16 | 3 | 0 | 1 | 8 | 0 | 0 | 8 | 42 | 1 | 1 | 1 | 0 | 2 | 22 | 117 | 4 | 12 | .151 | .216 | .208 | .424 | .132 | .057 | .234 | 6.84 | 35.90 | 5.25 | 106.00 | 2010- UDFA -CHN | premium | premium | premium | MLB | 2019-2021 | 2010-2023 | 2021 |
| 28 | Taylor Jones | 27 | 1B-LF | R | 90* | 35 | 102 | 11 | 25 | 8 | 1 | 2 | 16 | 0 | 0 | 4 | 29 | 0 | 0 | 2 | 0 | 5 | 41 | 108 | 11 | 14 | .245 | .269 | .402 | .671 | .196 | .157 | .315 | 3.70 | 26.85 | 7.25 | 51.00 | 2016- 19- 577-HOU | premium | premium | premium | MLB | 2020-2022 | 2013-2023 | 2021 |
| 26 | Jose Siri | 25 | RF-CF | R | 21 | 46 | 10 | 14 | 0 | 1 | 4 | 9 | 3 | 1 | 1 | 17 | 2 | 0 | 0 | 0 | 0 | 28 | 49 | 5 | 9 | .304 | .347 | .609 | .956 | .370 | .305 | .400 | 2.04 | 34.69 | 17.00 | 11.50 | 2012- UDFA -CIN | premium | premium | premium | MLB | 2021-2025 | 2013-2025 | 2021 | |
| 11 | Garrett Stubbs | 28 | C | L | 18 | 34 | 2 | 6 | 2 | 0 | 0 | 3 | 0 | 0 | 2 | 7 | 0 | 2 | 0 | 0 | 0 | 8 | 38 | 2 | 4 | .176 | .222 | .235 | .457 | .118 | .059 | .222 | 5.26 | 18.42 | 3.50 | 0.00 | 2015- 8- 229-HOU | premium | premium | premium | MLB | 2019-2025 | 2012-2025 | 2021 | |
| 12 | Marwin Gonzalez | 32 | 3B | B | 82 | 14 | 34 | 5 | 6 | 0 | 0 | 3 | 8 | 0 | 0 | 1 | 8 | 1 | 0 | 0 | 0 | 3 | 15 | 36 | 3 | 3 | .176 | .222 | .441 | .663 | .294 | .265 | .130 | 2.78 | 22.22 | 8.00 | 11.33 | 2005- UDFA -CHN | premium | premium | premium | MLB | 2012-2022 | 2006-2024 | 2021 |
| 13 | Jacob Wilson | 30 | 3B | R | 6 | 13 | 2 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 5 | 14 | 2 | 0 | .154 | .214 | .385 | .599 | .308 | .231 | .182 | 7.14 | 14.29 | 2.00 | 0.00 | 2012- 10- 330-SLN | premium | premium | premium | MLB | 2021-2021 | 2009-2021 | 2021 | |
| 77 | Luis Garcia | 24 | P | R | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 16.67 | 0.00 | 0.00 | 2017- UDFA -HOU | premium | premium | premium | MLB | 2020-2025 | 2017-2025 | 2021 | |
| 6 | Alex De Goti | 26 | 2B | R | 2 | 6 | 2 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 0 | 2 | .333 | .429 | .333 | .762 | .167 | .000 | .500 | 14.29 | 28.57 | 2.00 | 0.00 | 2016- 15- 457-HOU | premium | premium | premium | MLB | 2021-2021 | 2013-2025 | 2021 | |
| 31 | Ronnie Dawson | 26 | DH | L | 3 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 0 | 1 | .200 | .333 | .200 | .533 | .200 | .000 | .200 | 16.67 | 0.00 | 0.00 | 0.00 | 2016- 2- 61-HOU | premium | premium | premium | MLB | 2021-2022 | 2014-2025 | 2021 | |
| 43 | Lance McCullers | 27 | P | L | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 75.00 | 0.00 | 0.00 | 2012- 1- 41-HOU | premium | premium | premium | MLB | 2015-2025 | 2012-2025 | 2021 | |
| 59 | Framber Valdez | 27 | P | R | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2015- UDFA -HOU | premium | premium | premium | MLB | 2018-2025 | 2015-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 65 | Jose Urquidy | 26 | P | R | 2 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 1 | .250 | .250 | .250 | .500 | .000 | .000 | 1.000 | 0.00 | 75.00 | 0.00 | 0.00 | 2015- UDFA -HOU | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 | |
| 21 | Zack Greinke | 37 | P | R | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2002- 1- 6-KCA | premium | premium | premium | MLB | 2004-2023 | 2002-2023 | 2021 | |
| 17 | Jake Odorizzi | 31 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2008- 1- 32-MIL | premium | premium | premium | MLB | 2012-2022 | 2008-2024 | 2021 | |
| Totals: | 1655 | 5593 | 863 | 1496 | 299 | 14 | 221 | 834 | 53 | 16 | 569 | 1222 | 64 | 9 | 54 | 25 | 136 | 2486 | 6289 | 534 | 962 | .267 | .339 | .444 | .783 | .285 | .177 | .303 | 9.05 | 19.43 | 2.15 | 25.31 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 48 | Enoli Paredes | 25 | R | 0 | 0 | 6.23 | 12 | 0 | 0 | 0 | 12 | 1 | 0 | 8.2 | 7 | 10 | 6 | 0 | 17 | 15 | 1 | 0 | 2 | 2.77 | 7.27 | 0.00 | 17.65 | 15.58 | 10.38 | 0.88 | 2014- UDFA -HOU | premium | premium | premium | MLB | 2020-2024 | 2016-2025 | 2021 |
| 68 | Nivaldo Rodriguez | 24 | R | 0 | 0 | 2.45 | 4 | 0 | 0 | 0 | 4 | 4 | 0 | 7.1 | 4 | 2 | 2 | 2 | 4 | 3 | 0 | 0 | 3 | 1.09 | 4.91 | 2.45 | 4.91 | 3.68 | 2.45 | 0.75 | 2016- UDFA -HOU | premium | premium | premium | MLB | 2020-2021 | 2016-2023 | 2021 |
| 45 | Ryne Stanek | 29 | R | 3 | 5 | 3.42 | 72 | 0 | 0 | 0 | 72 | 13 | 2 | 68.1 | 46 | 32 | 26 | 8 | 37 | 83 | 6 | 0 | 5 | 1.21 | 6.06 | 1.05 | 4.87 | 10.93 | 4.21 | 2.24 | 2013- 1- 29-TBA | premium | premium | premium | MLB | 2017-2025 | 2011-2025 | 2021 |
| 55 | Ryan Pressly | 32 | R | 5 | 3 | 2.25 | 64 | 0 | 0 | 0 | 64 | 49 | 26 | 64.0 | 49 | 19 | 16 | 4 | 13 | 81 | 3 | 0 | 0 | 0.97 | 6.89 | 0.56 | 1.83 | 11.39 | 2.67 | 6.23 | 2007- 11- 354-BOS | premium | premium | premium | MLB | 2013-2025 | 2008-2025 | 2021 |
| 47 | Rafael Montero | 30 | R | 0 | 1 | 0.00 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 6.0 | 3 | 1 | 0 | 0 | 2 | 5 | 0 | 0 | 0 | 0.83 | 4.50 | 0.00 | 3.00 | 7.50 | 1.50 | 2.50 | 2011- UDFA -NYN | premium | premium | premium | MLB | 2014-2025 | 2011-2025 | 2021 |
| 64 | Brandon Bielak | 25 | R | 3 | 4 | 4.50 | 28 | 2 | 0 | 0 | 26 | 6 | 1 | 50.0 | 48 | 29 | 25 | 5 | 21 | 46 | 4 | 0 | 3 | 1.38 | 8.64 | 0.90 | 3.78 | 8.28 | 5.22 | 2.19 | 2017- 11- 331-HOU | premium | premium | premium | MLB | 2020-2024 | 2015-2025 | 2021 |
| 39 | Josh James | 28 | R | 0 | 0 | 5.40 | 5 | 0 | 0 | 0 | 5 | 5 | 0 | 5.0 | 4 | 3 | 3 | 1 | 2 | 8 | 2 | 0 | 0 | 1.20 | 7.20 | 1.80 | 3.60 | 14.40 | 5.40 | 4.00 | 2014- 34-1006-HOU | premium | premium | premium | MLB | 2018-2021 | 2012-2024 | 2021 |
| 58 | Brooks Raley | 33 | L | 2 | 3 | 4.78 | 58 | 0 | 0 | 0 | 58 | 9 | 2 | 49.0 | 43 | 30 | 26 | 6 | 16 | 65 | 1 | 1 | 3 | 1.20 | 7.90 | 1.10 | 2.94 | 11.94 | 5.51 | 4.06 | 2009- 6- 200-CHN | premium | premium | premium | MLB | 2012-2025 | 2008-2025 | 2021 |
| 62 | Blake Taylor | 25 | L | 4 | 4 | 3.16 | 51 | 0 | 0 | 0 | 51 | 10 | 0 | 42.2 | 38 | 19 | 15 | 6 | 22 | 41 | 5 | 0 | 0 | 1.41 | 8.02 | 1.27 | 4.64 | 8.65 | 4.01 | 1.86 | 2013- 2- 51-PIT | premium | premium | premium | MLB | 2020-2022 | 2013-2024 | 2021 |
| 63 | Tyler Ivey | 25 | R | 0 | 0 | 7.71 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.2 | 6 | 4 | 4 | 1 | 1 | 3 | 1 | 0 | 0 | 1.50 | 11.57 | 1.93 | 1.93 | 5.79 | 7.71 | 3.00 | 2017- 3- 91-HOU | premium | premium | premium | MLB | 2021-2021 | 2016-2025 | 2021 |
| 52 | Pedro Baez | 33 | R | 0 | 0 | 2.08 | 4 | 0 | 0 | 0 | 4 | 3 | 0 | 4.1 | 2 | 1 | 1 | 1 | 1 | 5 | 1 | 0 | 0 | 0.69 | 4.15 | 2.08 | 2.08 | 10.38 | 2.08 | 5.00 | 2007- UDFA -LAN | premium | premium | premium | MLB | 2014-2022 | 2007-2022 | 2021 |
| 66 | Bryan Abreu | 24 | R | 3 | 3 | 5.75 | 31 | 0 | 0 | 0 | 31 | 3 | 1 | 36.0 | 35 | 26 | 23 | 4 | 18 | 36 | 4 | 0 | 3 | 1.47 | 8.75 | 1.00 | 4.50 | 9.00 | 6.50 | 2.00 | 2013- UDFA -HOU | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 61 | Seth Martinez | 26 | R | 0 | 0 | 15.00 | 3 | 0 | 0 | 0 | 3 | 3 | 0 | 3.0 | 5 | 5 | 5 | 0 | 3 | 3 | 0 | 0 | 0 | 2.67 | 15.00 | 0.00 | 9.00 | 9.00 | 15.00 | 1.00 | 2016- 17- 502-OAK | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 88 | Phil Maton | 28 | R | 4 | 0 | 4.97 | 27 | 0 | 0 | 0 | 27 | 2 | 0 | 25.1 | 28 | 15 | 14 | 2 | 12 | 24 | 0 | 0 | 3 | 1.58 | 9.95 | 0.71 | 4.26 | 8.53 | 5.33 | 2.00 | 2015- 20- 597-SDN | premium | premium | premium | MLB | 2017-2025 | 2012-2025 | 2021 |
| 49 | Kendall Graveman | 30 | R | 1 | 1 | 3.13 | 23 | 0 | 0 | 0 | 23 | 3 | 0 | 23.0 | 20 | 8 | 8 | 1 | 12 | 27 | 1 | 0 | 5 | 1.39 | 7.83 | 0.39 | 4.70 | 10.57 | 3.13 | 2.25 | 2013- 8- 235-TOR | premium | premium | premium | MLB | 2014-2025 | 2010-2025 | 2021 |
| 43 | Joe Smith | 37 | R | 1 | 1 | 7.48 | 27 | 0 | 0 | 0 | 27 | 10 | 0 | 21.2 | 35 | 18 | 18 | 4 | 4 | 17 | 2 | 0 | 3 | 1.80 | 14.54 | 1.66 | 1.66 | 7.06 | 7.48 | 4.25 | 2006- 3- 94-NYN | premium | premium | premium | MLB | 2007-2022 | 2004-2022 | 2021 |
| 93 | Yimi Garcia | 30 | R | 1 | 2 | 5.48 | 23 | 0 | 0 | 0 | 23 | 8 | 0 | 21.1 | 18 | 15 | 13 | 3 | 5 | 25 | 0 | 0 | 0 | 1.08 | 7.59 | 1.27 | 2.11 | 10.55 | 6.33 | 5.00 | 2009- UDFA -LAN | premium | premium | premium | MLB | 2014-2025 | 2010-2025 | 2021 |
| 51 | Austin Pruitt | 31 | R | 0 | 1 | 6.75 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 2.2 | 3 | 2 | 2 | 2 | 0 | 1 | 0 | 0 | 1 | 1.12 | 10.12 | 6.75 | 0.00 | 3.37 | 6.75 | 0.00 | 2013- 9- 278-TBA | premium | premium | premium | MLB | 2017-2024 | 2012-2024 | 2021 |
| 69 | Ryan Hartman | 27 | L | 0 | 0 | 3.86 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 2.1 | 3 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 1.29 | 11.57 | 3.86 | 0.00 | 7.71 | 3.86 | 0.00 | 2016- 9- 277-HOU | premium | premium | premium | MLB | 2021-2021 | 2013-2023 | 2021 |
| 70 | Andre Scrubb | 26 | R | 1 | 1 | 5.03 | 18 | 0 | 0 | 0 | 18 | 5 | 0 | 19.2 | 15 | 11 | 11 | 5 | 14 | 21 | 2 | 0 | 0 | 1.47 | 6.86 | 2.29 | 6.41 | 9.61 | 5.03 | 1.50 | 2016- 8- 251-LAN | premium | premium | premium | MLB | 2020-2021 | 2014-2025 | 2021 |
| 21 | Zack Greinke | 37 | R | 11 | 6 | 4.16 | 30 | 29 | 1 | 0 | 1 | 0 | 0 | 171.0 | 164 | 82 | 79 | 30 | 36 | 120 | 3 | 0 | 2 | 1.17 | 8.63 | 1.58 | 1.89 | 6.32 | 4.32 | 3.33 | 2002- 1- 6-KCA | premium | premium | premium | MLB | 2004-2023 | 2002-2023 | 2021 |
| 72 | Kent Emanuel | 29 | L | 1 | 0 | 2.55 | 10 | 0 | 0 | 0 | 10 | 5 | 0 | 17.2 | 12 | 5 | 5 | 4 | 4 | 13 | 0 | 0 | 1 | 0.91 | 6.11 | 2.04 | 2.04 | 6.62 | 2.55 | 3.25 | 2013- 3- 74-HOU | premium | premium | premium | MLB | 2021-2024 | 2011-2025 | 2021 |
| 43 | Lance McCullers | 27 | R | 13 | 5 | 3.16 | 28 | 28 | 0 | 0 | 0 | 0 | 0 | 162.1 | 122 | 59 | 57 | 13 | 76 | 185 | 7 | 0 | 10 | 1.22 | 6.76 | 0.72 | 4.21 | 10.26 | 3.27 | 2.43 | 2012- 1- 41-HOU | premium | premium | premium | MLB | 2015-2025 | 2012-2025 | 2021 |
| 77 | Luis Garcia | 24 | R | 11 | 8 | 3.30 | 30 | 28 | 0 | 0 | 2 | 1 | 0 | 155.1 | 132 | 62 | 57 | 19 | 50 | 167 | 9 | 1 | 3 | 1.17 | 7.65 | 1.10 | 2.90 | 9.68 | 3.59 | 3.34 | 2017- UDFA -HOU | premium | premium | premium | MLB | 2020-2025 | 2017-2025 | 2021 |
| 71 | Peter Solomon | 24 | R | 1 | 0 | 1.29 | 6 | 0 | 0 | 0 | 6 | 3 | 0 | 14.0 | 10 | 2 | 2 | 0 | 8 | 10 | 2 | 0 | 0 | 1.29 | 6.43 | 0.00 | 5.14 | 6.43 | 1.29 | 1.25 | 2017- 4- 121-HOU | premium | premium | premium | MLB | 2021-2023 | 2015-2025 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 59 | Framber Valdez | 27 | L | 11 | 6 | 3.14 | 22 | 22 | 1 | 0 | 0 | 0 | 0 | 134.2 | 110 | 52 | 47 | 12 | 58 | 125 | 9 | 2 | 11 | 1.25 | 7.35 | 0.80 | 3.88 | 8.35 | 3.48 | 2.16 | 2015- UDFA -HOU | premium | premium | premium | MLB | 2018-2025 | 2015-2025 | 2021 |
| 61 | Ralph Garza | 27 | R | 1 | 2 | 4.09 | 9 | 0 | 0 | 0 | 9 | 8 | 0 | 11.0 | 11 | 6 | 5 | 2 | 7 | 14 | 1 | 0 | 0 | 1.64 | 9.00 | 1.64 | 5.73 | 11.45 | 4.91 | 2.00 | 2015- 26- 769-HOU | premium | premium | premium | MLB | 2021-2022 | 2013-2025 | 2021 |
| 65 | Jose Urquidy | 26 | R | 8 | 3 | 3.62 | 20 | 20 | 0 | 0 | 0 | 0 | 0 | 107.0 | 87 | 43 | 43 | 17 | 19 | 90 | 2 | 0 | 2 | 0.99 | 7.32 | 1.43 | 1.60 | 7.57 | 3.62 | 4.74 | 2015- UDFA -HOU | premium | premium | premium | MLB | 2019-2025 | 2015-2025 | 2021 |
| 17 | Jake Odorizzi | 31 | R | 6 | 7 | 4.21 | 24 | 23 | 0 | 0 | 1 | 0 | 0 | 104.2 | 97 | 51 | 49 | 16 | 34 | 91 | 0 | 0 | 3 | 1.25 | 8.34 | 1.38 | 2.92 | 7.82 | 4.39 | 2.68 | 2008- 1- 32-MIL | premium | premium | premium | MLB | 2012-2022 | 2008-2024 | 2021 |
| 53 | Cristian Javier | 24 | R | 4 | 1 | 3.55 | 36 | 9 | 0 | 0 | 27 | 5 | 2 | 101.1 | 67 | 41 | 40 | 16 | 53 | 130 | 6 | 0 | 7 | 1.18 | 5.95 | 1.42 | 4.71 | 11.55 | 3.64 | 2.45 | 2015- UDFA -HOU | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 9 | Robel Garcia | 28 | R | 0 | 0 | 36.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1.0 | 5 | 4 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 5.00 | 45.00 | 18.00 | 0.00 | 0.00 | 36.00 | 0.00 | 2010- UDFA -CHN | premium | premium | premium | MLB | 2019-2021 | 2010-2023 | 2021 |
| Totals: | 95 | 67 | 3.78 | 674 | 162 | 2 | 0 | 160 | 512 | 34 | 1445.0 | 1229 | 658 | 607 | 187 | 549 | 1456 | 72 | 4 | 70 | 1.23 | 7.65 | 1.16 | 3.42 | 9.07 | 4.10 | 2.65 | premium | premium | premium |