| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 7 | Jonathan Schoop | 29 | 1B | R | 103 | 156 | 623 | 85 | 173 | 30 | 1 | 22 | 84 | 2 | 0 | 37 | 133 | 6 | 0 | 8 | 0 | 15 | 271 | 674 | 53 | 120 | .278 | .320 | .435 | .755 | .220 | .157 | .317 | 5.49 | 19.73 | 3.59 | 28.32 | 2008- UDFA -BAL | premium | premium | premium | MLB | 2013-2023 | 2010-2025 | 2021 |
| 46 | Jeimer Candelario | 27 | 3B | B | 109 | 149 | 557 | 75 | 151 | 42 | 3 | 16 | 67 | 0 | 0 | 65 | 135 | 4 | 0 | 0 | 1 | 10 | 247 | 626 | 61 | 90 | .271 | .351 | .443 | .794 | .289 | .172 | .333 | 10.38 | 21.57 | 2.08 | 34.81 | 2010- UDFA -CHN | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 8 | Robbie Grossman | 31 | LF-RF | B | 108 | 156 | 557 | 88 | 133 | 23 | 3 | 23 | 67 | 20 | 5 | 98 | 155 | 8 | 2 | 6 | 3 | 8 | 231 | 671 | 49 | 84 | .239 | .357 | .415 | .772 | .379 | .176 | .286 | 14.61 | 23.10 | 1.58 | 24.22 | 2008- 6- 174-PIT | premium | premium | premium | MLB | 2013-2024 | 2008-2024 | 2021 |
| 24 | Miguel Cabrera | 38 | DH-1B | R | 97 | 130 | 472 | 48 | 121 | 16 | 0 | 15 | 75 | 0 | 0 | 40 | 118 | 5 | 0 | 9 | 0 | 21 | 182 | 526 | 31 | 90 | .256 | .316 | .386 | .702 | .214 | .130 | .305 | 7.60 | 22.43 | 2.95 | 31.47 | 1999- UDFA -MIA | premium | premium | premium | MLB | 2003-2023 | 2000-2023 | 2021 |
| 9 | Willi Castro | 24 | 2B | B | 86 | 125 | 413 | 56 | 91 | 15 | 6 | 9 | 38 | 9 | 4 | 23 | 109 | 8 | 3 | 3 | 1 | 5 | 145 | 450 | 30 | 61 | .220 | .273 | .351 | .624 | .199 | .131 | .275 | 5.11 | 24.22 | 4.74 | 45.89 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 60 | Akil Baddoo | 22 | CF-LF | L | 106 | 124 | 413 | 60 | 107 | 20 | 7 | 13 | 55 | 18 | 4 | 45 | 122 | 0 | 0 | 3 | 1 | 5 | 180 | 461 | 40 | 67 | .259 | .330 | .436 | .766 | .320 | .177 | .335 | 9.76 | 26.46 | 2.71 | 31.77 | 2016- 2- 74-MIN | premium | premium | premium | MLB | 2021-2025 | 2016-2025 | 2021 |
| 13 | Eric Haase | 28 | C | R | 101 | 98 | 351 | 48 | 81 | 12 | 1 | 22 | 61 | 2 | 0 | 26 | 119 | 2 | 0 | 2 | 0 | 11 | 161 | 381 | 35 | 46 | .231 | .286 | .459 | .745 | .308 | .228 | .278 | 6.82 | 31.23 | 4.58 | 15.95 | 2011- 7- 218-CLE | premium | premium | premium | MLB | 2018-2025 | 2011-2025 | 2021 |
| 30 | Harold Castro | 27 | SS-2B | L | 92 | 106 | 315 | 35 | 89 | 13 | 1 | 3 | 37 | 1 | 1 | 14 | 72 | 1 | 4 | 5 | 0 | 7 | 113 | 339 | 17 | 72 | .283 | .310 | .359 | .669 | .121 | .076 | .351 | 4.13 | 21.24 | 5.14 | 105.00 | 2011- UDFA -DET | premium | premium | premium | MLB | 2018-2023 | 2012-2025 | 2021 |
| 28 | Niko Goodrum | 29 | SS | B | 91 | 90 | 290 | 39 | 62 | 11 | 2 | 9 | 33 | 14 | 5 | 29 | 107 | 4 | 0 | 2 | 0 | 6 | 104 | 325 | 22 | 40 | .214 | .292 | .359 | .651 | .276 | .145 | .301 | 8.92 | 32.92 | 3.69 | 32.22 | 2010- 2- 71-MIN | premium | premium | premium | MLB | 2017-2024 | 2010-2025 | 2021 |
| 22 | Victor Reyes | 26 | RF | B | 96 | 76 | 209 | 26 | 54 | 10 | 4 | 5 | 22 | 5 | 1 | 8 | 55 | 0 | 2 | 1 | 0 | 2 | 87 | 220 | 19 | 35 | .258 | .284 | .416 | .700 | .215 | .158 | .327 | 3.64 | 25.00 | 6.88 | 41.80 | 2011- UDFA -ATL | premium | premium | premium | MLB | 2018-2022 | 2012-2023 | 2021 |
| 15 | Nomar Mazara | 26 | RF | L | 83* | 50 | 165 | 12 | 35 | 5 | 2 | 3 | 19 | 0 | 0 | 15 | 45 | 0 | 0 | 1 | 0 | 4 | 53 | 181 | 10 | 25 | .212 | .276 | .321 | .597 | .200 | .109 | .271 | 8.29 | 24.86 | 3.00 | 55.00 | 2011- UDFA -TEX | premium | premium | premium | MLB | 2016-2022 | 2012-2025 | 2021 |
| 59 | Zack Short | 26 | SS | R | 74* | 61 | 156 | 21 | 22 | 4 | 0 | 6 | 20 | 2 | 0 | 22 | 59 | 0 | 0 | 6 | 1 | 4 | 44 | 184 | 10 | 12 | .141 | .239 | .282 | .521 | .295 | .141 | .165 | 11.96 | 32.07 | 2.68 | 26.00 | 2016- 17- 524-CHN | premium | premium | premium | MLB | 2021-2025 | 2014-2025 | 2021 |
| 54 | Derek Hill | 25 | CF | R | 97* | 49 | 139 | 19 | 36 | 3 | 3 | 3 | 14 | 6 | 3 | 10 | 42 | 1 | 0 | 0 | 0 | 2 | 54 | 150 | 9 | 27 | .259 | .313 | .388 | .701 | .223 | .129 | .351 | 6.67 | 28.00 | 4.20 | 46.33 | 2014- 1- 23-DET | premium | premium | premium | MLB | 2020-2025 | 2014-2025 | 2021 |
| 40 | Wilson Ramos | 33 | C | R | 88* | 35 | 120 | 12 | 24 | 5 | 0 | 6 | 13 | 0 | 0 | 6 | 29 | 0 | 0 | 0 | 0 | 1 | 47 | 126 | 11 | 13 | .200 | .238 | .392 | .630 | .242 | .192 | .212 | 4.76 | 23.02 | 4.83 | 20.00 | 2004- UDFA -MIN | premium | premium | premium | MLB | 2010-2021 | 2006-2023 | 2021 |
| 34 | Jake Rogers | 26 | C | R | 108* | 38 | 113 | 17 | 27 | 5 | 3 | 6 | 17 | 1 | 0 | 11 | 46 | 0 | 3 | 0 | 0 | 0 | 56 | 127 | 14 | 13 | .239 | .306 | .496 | .802 | .363 | .257 | .344 | 8.66 | 36.22 | 4.18 | 18.83 | 2016- 3- 97-HOU | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| 41 | Daz Cameron | 24 | RF-CF | R | 92* | 35 | 103 | 16 | 20 | 5 | 0 | 4 | 13 | 6 | 0 | 10 | 38 | 2 | 0 | 0 | 0 | 2 | 37 | 115 | 9 | 11 | .194 | .278 | .359 | .637 | .320 | .165 | .262 | 8.70 | 33.04 | 3.80 | 25.75 | 2015- 1- 37-HOU | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 21 | JaCoby Jones | 29 | CF | R | 63* | 36 | 100 | 9 | 17 | 2 | 0 | 2 | 9 | 2 | 2 | 5 | 42 | 0 | 0 | 0 | 0 | 2 | 25 | 105 | 4 | 13 | .170 | .210 | .250 | .460 | .130 | .080 | .268 | 4.76 | 40.00 | 8.40 | 50.00 | 2013- 3- 87-PIT | premium | premium | premium | MLB | 2016-2021 | 2011-2022 | 2021 |
| 17 | Grayson Greiner | 28 | C | R | 31 | 72 | 7 | 17 | 4 | 0 | 1 | 7 | 0 | 0 | 9 | 31 | 0 | 1 | 0 | 0 | 0 | 24 | 82 | 5 | 12 | .236 | .321 | .333 | .654 | .222 | .097 | .400 | 10.98 | 37.80 | 3.44 | 72.00 | 2014- 3- 99-DET | premium | premium | premium | MLB | 2018-2022 | 2012-2023 | 2021 | |
| 19 | Isaac Paredes | 22 | 2B-3B | R | 23 | 72 | 7 | 15 | 3 | 1 | 1 | 5 | 0 | 0 | 10 | 11 | 1 | 0 | 2 | 1 | 4 | 23 | 85 | 5 | 10 | .208 | .306 | .319 | .625 | .250 | .111 | .226 | 11.76 | 12.94 | 1.10 | 72.00 | 2015- UDFA -CHN | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 | |
| 64 | Dustin Garneau | 33 | C | R | 20 | 62 | 9 | 13 | 5 | 0 | 6 | 11 | 0 | 0 | 3 | 18 | 1 | 0 | 2 | 0 | 2 | 36 | 68 | 11 | 2 | .210 | .250 | .581 | .831 | .419 | .371 | .175 | 4.41 | 26.47 | 6.00 | 10.33 | 2009- 19- 571-COL | premium | premium | premium | MLB | 2015-2022 | 2006-2022 | 2021 | |
| 55 | Renato Nunez | 27 | 1B-DH | R | 14 | 53 | 7 | 10 | 3 | 0 | 4 | 7 | 0 | 0 | 1 | 16 | 1 | 0 | 0 | 0 | 2 | 25 | 55 | 7 | 3 | .189 | .218 | .472 | .690 | .302 | .283 | .182 | 1.82 | 29.09 | 16.00 | 13.25 | 2010- UDFA -OAK | premium | premium | premium | MLB | 2016-2021 | 2011-2025 | 2021 | |
| 74 | Jacob Robson | 26 | LF | L | 4 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 57.14 | 0.00 | 0.00 | 2016- 8- 235-DET | premium | premium | premium | MLB | 2021-2021 | 2013-2025 | 2021 | |
| 41 | Matthew Boyd | 30 | P | L | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 5 | 0 | 1 | .333 | .500 | .333 | .833 | .333 | .000 | .500 | 20.00 | 20.00 | 1.00 | 0.00 | 2013- 6- 175-TOR | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 | |
| 70 | Tyler Alexander | 26 | P | R | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 2015- 2- 65-DET | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 | |
| 12 | Casey Mize | 24 | P | R | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .333 | .000 | .333 | .500 | .000 | .000 | 33.33 | 33.33 | 1.00 | 0.00 | 2018- 1- 1-DET | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 29 | Tarik Skubal | 24 | P | R | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 66.67 | 0.00 | 0.00 | 2018- 9- 255-DET | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 | |
| 25 | Matt Manning | 23 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2016- 1- 9-DET | premium | premium | premium | MLB | 2021-2024 | 2016-2025 | 2021 | |
| 51 | Rony Garcia | 23 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2015- UDFA -NYA | premium | premium | premium | MLB | 2020-2022 | 2016-2023 | 2021 | |
| 58 | Wily Peralta | 32 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .500 | .000 | .500 | 1.000 | .000 | .000 | 50.00 | 0.00 | 0.00 | 0.00 | 2005- UDFA -MIL | premium | premium | premium | MLB | 2012-2022 | 2006-2025 | 2021 | |
| 40 | Drew Hutchison | 30 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2009- 15- 460-TOR | premium | premium | premium | MLB | 2012-2022 | 2010-2024 | 2021 | |
| 62 | Jose Urena | 29 | P | R | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2008- UDFA -MIA | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 | |
| Totals: | 1622 | 5376 | 697 | 1299 | 236 | 37 | 179 | 675 | 88 | 25 | 490 | 1514 | 44 | 17 | 50 | 8 | 113 | 2146 | 5977 | 452 | 847 | .242 | .308 | .399 | .707 | .260 | .158 | .300 | 8.20 | 25.33 | 3.09 | 30.03 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 58 | Wily Peralta | 32 | R | 4 | 5 | 3.07 | 19 | 18 | 0 | 0 | 1 | 0 | 0 | 93.2 | 87 | 41 | 32 | 12 | 38 | 58 | 1 | 0 | 4 | 1.33 | 8.36 | 1.15 | 3.65 | 5.57 | 3.94 | 1.53 | 2005- UDFA -MIL | premium | premium | premium | MLB | 2012-2022 | 2006-2025 | 2021 |
| 25 | Matt Manning | 23 | R | 4 | 7 | 5.80 | 18 | 18 | 0 | 0 | 0 | 0 | 0 | 85.1 | 96 | 59 | 55 | 10 | 33 | 57 | 1 | 0 | 3 | 1.51 | 10.13 | 1.05 | 3.48 | 6.01 | 6.22 | 1.73 | 2016- 1- 9-DET | premium | premium | premium | MLB | 2021-2024 | 2016-2025 | 2021 |
| 41 | Matthew Boyd | 30 | L | 3 | 8 | 3.89 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 78.2 | 77 | 37 | 34 | 9 | 23 | 67 | 4 | 0 | 7 | 1.27 | 8.81 | 1.03 | 2.63 | 7.67 | 4.23 | 2.91 | 2013- 6- 175-TOR | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 |
| 32 | Michael Fulmer | 28 | R | 5 | 6 | 2.97 | 52 | 4 | 0 | 0 | 48 | 21 | 14 | 69.2 | 69 | 27 | 23 | 7 | 20 | 73 | 2 | 0 | 5 | 1.28 | 8.91 | 0.90 | 2.58 | 9.43 | 3.49 | 3.65 | 2011- 1- 44-NYN | premium | premium | premium | MLB | 2016-2025 | 2011-2025 | 2021 |
| 36 | Kyle Funkhouser | 27 | R | 7 | 4 | 3.42 | 57 | 2 | 0 | 0 | 55 | 7 | 1 | 68.1 | 58 | 32 | 26 | 6 | 38 | 63 | 9 | 1 | 3 | 1.40 | 7.64 | 0.79 | 5.00 | 8.30 | 4.21 | 1.66 | 2016- 4- 115-DET | premium | premium | premium | MLB | 2020-2021 | 2013-2025 | 2021 |
| 65 | Gregory Soto | 26 | L | 6 | 3 | 3.39 | 62 | 0 | 0 | 0 | 62 | 38 | 18 | 63.2 | 46 | 30 | 24 | 7 | 40 | 76 | 11 | 1 | 1 | 1.35 | 6.50 | 0.99 | 5.65 | 10.74 | 4.24 | 1.90 | 2012- UDFA -DET | premium | premium | premium | MLB | 2019-2025 | 2013-2025 | 2021 |
| 67 | Jose Cisnero | 32 | R | 4 | 4 | 3.65 | 67 | 0 | 0 | 0 | 67 | 11 | 4 | 61.2 | 51 | 34 | 25 | 6 | 31 | 62 | 4 | 0 | 4 | 1.33 | 7.44 | 0.88 | 4.52 | 9.05 | 4.96 | 2.00 | 2007- UDFA -HOU | premium | premium | premium | MLB | 2013-2024 | 2009-2024 | 2021 |
| 56 | Spencer Turnbull | 28 | R | 4 | 2 | 2.88 | 9 | 9 | 1 | 1 | 0 | 0 | 0 | 50.0 | 37 | 18 | 16 | 2 | 12 | 44 | 0 | 0 | 5 | 0.98 | 6.66 | 0.36 | 2.16 | 7.92 | 3.24 | 3.67 | 2014- 2- 63-DET | premium | premium | premium | MLB | 2018-2025 | 2012-2025 | 2021 |
| 71 | Miguel Del Pozo | 28 | L | 0 | 0 | 3.38 | 5 | 0 | 0 | 0 | 5 | 1 | 0 | 5.1 | 8 | 2 | 2 | 0 | 2 | 4 | 0 | 0 | 0 | 1.88 | 13.50 | 0.00 | 3.38 | 6.75 | 3.38 | 2.00 | 2010- UDFA -MIA | premium | premium | premium | MLB | 2019-2021 | 2011-2023 | 2021 |
| 50 | Julio Teheran | 30 | R | 1 | 0 | 1.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 1.40 | 7.20 | 1.80 | 5.40 | 5.40 | 1.80 | 1.00 | 2007- UDFA -ATL | premium | premium | premium | MLB | 2011-2024 | 2008-2025 | 2021 |
| 49 | Derek Holland | 34 | L | 3 | 2 | 5.07 | 39 | 1 | 0 | 0 | 38 | 12 | 0 | 49.2 | 58 | 29 | 28 | 6 | 20 | 51 | 2 | 0 | 1 | 1.57 | 10.51 | 1.09 | 3.62 | 9.24 | 5.26 | 2.55 | 2006- 25- 748-TEX | premium | premium | premium | MLB | 2009-2021 | 2007-2023 | 2021 |
| 77 | Joe Jimenez | 26 | R | 6 | 1 | 5.96 | 52 | 0 | 0 | 0 | 52 | 12 | 1 | 45.1 | 34 | 33 | 30 | 6 | 35 | 57 | 6 | 0 | 8 | 1.52 | 6.75 | 1.19 | 6.95 | 11.32 | 6.55 | 1.63 | 2013- UDFA -DET | premium | premium | premium | MLB | 2017-2024 | 2013-2024 | 2021 |
| 33 | Bryan Garcia | 26 | R | 3 | 2 | 7.55 | 39 | 0 | 0 | 0 | 39 | 10 | 2 | 39.1 | 48 | 38 | 33 | 10 | 25 | 32 | 7 | 0 | 2 | 1.86 | 10.98 | 2.29 | 5.72 | 7.32 | 8.69 | 1.28 | 2016- 6- 175-DET | premium | premium | premium | MLB | 2019-2022 | 2014-2024 | 2021 |
| 44 | Daniel Norris | 28 | L | 1 | 3 | 5.89 | 38 | 0 | 0 | 0 | 38 | 10 | 1 | 36.2 | 38 | 25 | 24 | 4 | 15 | 40 | 3 | 0 | 2 | 1.45 | 9.33 | 0.98 | 3.68 | 9.82 | 6.14 | 2.67 | 2011- 2- 74-TOR | premium | premium | premium | MLB | 2014-2023 | 2012-2023 | 2021 |
| 57 | Alex Lange | 25 | R | 1 | 3 | 4.04 | 36 | 0 | 0 | 0 | 36 | 6 | 1 | 35.2 | 37 | 18 | 16 | 5 | 16 | 39 | 6 | 0 | 3 | 1.49 | 9.34 | 1.26 | 4.04 | 9.84 | 4.54 | 2.44 | 2017- 1- 30-CHN | premium | premium | premium | MLB | 2021-2025 | 2015-2025 | 2021 |
| 45 | Buck Farmer | 30 | R | 0 | 0 | 6.37 | 36 | 0 | 0 | 0 | 36 | 8 | 0 | 35.1 | 40 | 25 | 25 | 9 | 21 | 37 | 2 | 0 | 5 | 1.73 | 10.19 | 2.29 | 5.35 | 9.42 | 6.37 | 1.76 | 2013- 5- 156-DET | premium | premium | premium | MLB | 2014-2024 | 2010-2025 | 2021 |
| 73 | Drew Carlton | 25 | R | 0 | 0 | 4.91 | 4 | 0 | 0 | 0 | 4 | 1 | 0 | 3.2 | 6 | 2 | 2 | 1 | 4 | 1 | 0 | 0 | 0 | 2.73 | 14.73 | 2.45 | 9.82 | 2.45 | 4.91 | 0.25 | 2017- 32- 965-DET | premium | premium | premium | MLB | 2021-2023 | 2015-2023 | 2021 |
| 51 | Rony Garcia | 23 | R | 0 | 0 | 2.45 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 3.2 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | 0 | 0 | 0.82 | 2.45 | 2.45 | 4.91 | 4.91 | 2.45 | 1.00 | 2015- UDFA -NYA | premium | premium | premium | MLB | 2020-2022 | 2016-2023 | 2021 |
| 66 | Erasmo Ramirez | 31 | R | 1 | 1 | 5.74 | 17 | 0 | 0 | 0 | 17 | 3 | 0 | 26.2 | 24 | 17 | 17 | 4 | 5 | 20 | 0 | 0 | 1 | 1.09 | 8.10 | 1.35 | 1.69 | 6.75 | 5.74 | 4.00 | 2007- UDFA -SEA | premium | premium | premium | MLB | 2012-2025 | 2010-2025 | 2021 |
| 40 | Drew Hutchison | 30 | R | 3 | 1 | 2.11 | 9 | 2 | 0 | 0 | 7 | 0 | 0 | 21.1 | 20 | 11 | 5 | 1 | 11 | 10 | 1 | 0 | 0 | 1.45 | 8.44 | 0.42 | 4.64 | 4.22 | 4.64 | 0.91 | 2009- 15- 460-TOR | premium | premium | premium | MLB | 2012-2022 | 2010-2024 | 2021 |
| 30 | Harold Castro | 27 | R | 0 | 0 | 0.00 | 3 | 0 | 0 | 0 | 3 | 3 | 0 | 2.2 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 1.12 | 0.00 | 0.00 | 10.12 | 0.00 | 0.00 | 0.00 | 2011- UDFA -DET | premium | premium | premium | MLB | 2018-2023 | 2012-2025 | 2021 |
| 63 | Ian Krol | 30 | L | 0 | 0 | 4.34 | 18 | 0 | 0 | 0 | 18 | 7 | 0 | 18.2 | 23 | 10 | 9 | 2 | 8 | 18 | 1 | 1 | 0 | 1.66 | 11.09 | 0.96 | 3.86 | 8.68 | 4.82 | 2.25 | 2009- 7- 213-OAK | premium | premium | premium | MLB | 2013-2021 | 2009-2025 | 2021 |
| 12 | Casey Mize | 24 | R | 7 | 9 | 3.71 | 30 | 30 | 1 | 0 | 0 | 0 | 0 | 150.1 | 130 | 64 | 62 | 24 | 41 | 118 | 7 | 0 | 11 | 1.14 | 7.78 | 1.44 | 2.45 | 7.06 | 3.83 | 2.88 | 2018- 1- 1-DET | premium | premium | premium | MLB | 2020-2025 | 2016-2025 | 2021 |
| 29 | Tarik Skubal | 24 | L | 8 | 12 | 4.34 | 31 | 29 | 0 | 0 | 2 | 1 | 0 | 149.1 | 141 | 76 | 72 | 35 | 47 | 164 | 4 | 0 | 6 | 1.26 | 8.50 | 2.11 | 2.83 | 9.88 | 4.58 | 3.49 | 2018- 9- 255-DET | premium | premium | premium | MLB | 2020-2025 | 2015-2025 | 2021 |
| 70 | Tyler Alexander | 26 | L | 2 | 4 | 3.81 | 41 | 15 | 0 | 0 | 26 | 7 | 0 | 106.1 | 106 | 47 | 45 | 16 | 28 | 87 | 2 | 0 | 4 | 1.26 | 8.97 | 1.35 | 2.37 | 7.36 | 3.98 | 3.11 | 2015- 2- 65-DET | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 62 | Jose Urena | 29 | R | 4 | 8 | 5.81 | 26 | 18 | 0 | 0 | 8 | 1 | 0 | 100.2 | 119 | 70 | 65 | 14 | 42 | 67 | 4 | 0 | 4 | 1.60 | 10.64 | 1.25 | 3.75 | 5.99 | 6.26 | 1.60 | 2008- UDFA -MIA | premium | premium | premium | MLB | 2015-2025 | 2010-2025 | 2021 |
| 68 | Jason Foley | 25 | R | 0 | 0 | 2.61 | 11 | 0 | 0 | 0 | 11 | 1 | 0 | 10.1 | 8 | 3 | 3 | 1 | 5 | 6 | 3 | 0 | 3 | 1.26 | 6.97 | 0.87 | 4.35 | 5.23 | 2.61 | 1.20 | 2016- UDFA -DET | premium | premium | premium | MLB | 2021-2024 | 2014-2025 | 2021 |
| 37 | Beau Burrows | 24 | R | 0 | 0 | 21.60 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.2 | 2 | 4 | 4 | 0 | 2 | 3 | 0 | 0 | 0 | 2.40 | 10.80 | 0.00 | 10.80 | 16.20 | 21.60 | 1.50 | 2015- 1- 22-DET | premium | premium | premium | MLB | 2020-2021 | 2015-2025 | 2021 |
| 34 | Jake Rogers | 26 | R | 0 | 0 | 18.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.0 | 2 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 3.00 | 18.00 | 0.00 | 9.00 | 0.00 | 18.00 | 0.00 | 2016- 3- 97-HOU | premium | premium | premium | MLB | 2019-2025 | 2014-2025 | 2021 |
| Totals: | 77 | 85 | 4.32 | 739 | 162 | 2 | 1 | 160 | 577 | 42 | 1419.2 | 1370 | 756 | 681 | 199 | 571 | 1259 | 80 | 3 | 82 | 1.37 | 8.69 | 1.26 | 3.62 | 7.98 | 4.79 | 2.20 | premium | premium | premium |