| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 30 | Jesus Aguilar | 26 | 1B | R | 111 | 137 | 515 | 62 | 127 | 26 | 0 | 30 | 92 | 0 | 0 | 53 | 110 | 4 | 1 | 5 | 2 | 20 | 243 | 578 | 56 | 71 | .247 | .319 | .472 | .791 | .328 | .225 | .255 | 9.17 | 19.03 | 2.08 | 17.17 | 2007- UDFA -CLE | premium | premium | premium | MLB | 2014-2023 | 2010-2024 | 2016 |
| 23 | Gio Urshela | 24 | 3B | R | 95 | 117 | 468 | 54 | 128 | 24 | 1 | 8 | 57 | 0 | 0 | 15 | 58 | 1 | 1 | 6 | 0 | 11 | 178 | 491 | 33 | 95 | .274 | .294 | .380 | .674 | .139 | .106 | .294 | 3.05 | 11.81 | 3.87 | 58.50 | 2008- UDFA -CLE | premium | premium | premium | MLB | 2015-2025 | 2009-2025 | 2016 |
| 13 | Ronny Rodriguez | 24 | 2B | R | 97 | 116 | 450 | 58 | 116 | 24 | 5 | 10 | 59 | 4 | 4 | 22 | 88 | 2 | 10 | 4 | 1 | 5 | 180 | 488 | 39 | 77 | .258 | .293 | .400 | .693 | .191 | .142 | .298 | 4.51 | 18.03 | 4.00 | 45.00 | 2010- UDFA -CLE | premium | premium | premium | MLB | 2018-2019 | 2011-2024 | 2016 |
| 11 | Erik Gonzalez | 24 | SS | R | 108 | 104 | 429 | 62 | 127 | 31 | 1 | 11 | 53 | 12 | 10 | 19 | 88 | 3 | 7 | 2 | 2 | 8 | 193 | 460 | 43 | 84 | .296 | .329 | .450 | .779 | .203 | .154 | .349 | 4.13 | 19.13 | 4.63 | 39.00 | 2008- UDFA -CLE | premium | premium | premium | MLB | 2016-2022 | 2010-2024 | 2016 |
| 2 | Joey Butler | 30 | LF-RF | R | 96 | 118 | 413 | 54 | 99 | 15 | 2 | 8 | 42 | 4 | 1 | 45 | 106 | 3 | 2 | 1 | 2 | 9 | 142 | 464 | 25 | 74 | .240 | .318 | .344 | .662 | .220 | .104 | .303 | 9.70 | 22.84 | 2.36 | 51.63 | 2008- 15- 453-TEX | premium | premium | premium | MLB | 2013-2015 | 2007-2017 | 2016 |
| 27 | Yandy Diaz | 24 | 3B-RF | R | 122 | 95 | 360 | 53 | 117 | 22 | 3 | 7 | 44 | 5 | 1 | 47 | 70 | 1 | 2 | 6 | 1 | 7 | 166 | 416 | 32 | 85 | .325 | .399 | .461 | .860 | .278 | .136 | .381 | 11.30 | 16.83 | 1.49 | 51.43 | 2013- UDFA -CLE | premium | premium | premium | MLB | 2017-2025 | 2014-2025 | 2016 |
| 7 | Collin Cowgill | 30 | CF-RF | R | 93 | 103 | 359 | 46 | 84 | 17 | 1 | 4 | 30 | 7 | 2 | 34 | 85 | 7 | 5 | 2 | 0 | 4 | 115 | 407 | 22 | 62 | .234 | .311 | .320 | .631 | .195 | .086 | .294 | 8.35 | 20.88 | 2.50 | 89.75 | 2008- 5- 168-ARI | premium | premium | premium | MLB | 2011-2016 | 2005-2019 | 2016 |
| 25 | Adam Moore | 32 | C | R | 98 | 86 | 299 | 35 | 74 | 14 | 0 | 7 | 31 | 0 | 0 | 26 | 63 | 4 | 0 | 0 | 1 | 16 | 109 | 329 | 21 | 53 | .247 | .316 | .365 | .681 | .204 | .118 | .293 | 7.90 | 19.15 | 2.42 | 42.71 | 2006- 6- 171-SEA | premium | premium | premium | MLB | 2009-2018 | 2005-2019 | 2016 |
| 29 | Guillermo Quiroz | 34 | C | R | 108 | 75 | 273 | 41 | 72 | 17 | 0 | 11 | 38 | 0 | 0 | 16 | 68 | 5 | 1 | 2 | 0 | 10 | 122 | 297 | 28 | 44 | .264 | .314 | .447 | .761 | .242 | .183 | .311 | 5.39 | 22.90 | 4.25 | 24.82 | 1998- UDFA -TOR | premium | premium | premium | MLB | 2004-2014 | 1999-2016 | 2016 |
| 9 | Michael Choice | 26 | LF-RF | R | 107 | 71 | 252 | 33 | 62 | 11 | 0 | 14 | 39 | 0 | 1 | 14 | 81 | 8 | 0 | 2 | 0 | 0 | 115 | 276 | 25 | 37 | .246 | .304 | .456 | .760 | .262 | .210 | .302 | 5.07 | 29.35 | 5.79 | 18.00 | 2010- 1- 10-OAK | premium | premium | premium | MLB | 2013-2015 | 2008-2021 | 2016 |
| 15 | Yhoxian Medina | 26 | 2B-SS | R | 95 | 67 | 222 | 28 | 57 | 13 | 1 | 3 | 20 | 5 | 2 | 8 | 32 | 6 | 5 | 2 | 0 | 2 | 81 | 243 | 17 | 40 | .257 | .298 | .365 | .663 | .158 | .108 | .286 | 3.29 | 13.17 | 4.00 | 74.00 | 2011- 38-1148-CLE | premium | premium | premium | AAA | 2012-2019 | 2016 | |
| 6 | Bradley Zimmer | 23 | CF | L | 99* | 37 | 128 | 18 | 31 | 5 | 0 | 1 | 9 | 5 | 1 | 21 | 56 | 0 | 1 | 0 | 0 | 1 | 39 | 150 | 6 | 25 | .242 | .349 | .305 | .654 | .258 | .063 | .423 | 14.00 | 37.33 | 2.67 | 128.00 | 2014- 1- 21-CLE | premium | premium | premium | MLB | 2017-2022 | 2012-2023 | 2016 |
| 8 | Robbie Grossman | 26 | CF-LF | B | 116* | 34 | 117 | 14 | 30 | 5 | 0 | 6 | 13 | 3 | 1 | 21 | 25 | 0 | 1 | 0 | 2 | 2 | 53 | 139 | 11 | 19 | .256 | .370 | .453 | .823 | .393 | .197 | .279 | 15.11 | 17.99 | 1.19 | 19.50 | 2008- 6- 174-PIT | premium | premium | premium | MLB | 2013-2024 | 2008-2024 | 2016 |
| 7 | Michael Martinez | 33 | 2B | B | 111* | 27 | 104 | 12 | 30 | 8 | 1 | 2 | 12 | 2 | 2 | 9 | 21 | 1 | 0 | 0 | 1 | 1 | 46 | 114 | 11 | 19 | .288 | .351 | .442 | .793 | .240 | .154 | .346 | 7.89 | 18.42 | 2.33 | 52.00 | 2005- UDFA -WAS | premium | premium | premium | MLB | 2011-2017 | 2006-2024 | 2016 |
| 6 | Bryson Myles | 26 | LF-RF | R | 95* | 33 | 94 | 10 | 22 | 4 | 1 | 1 | 9 | 5 | 0 | 8 | 25 | 2 | 0 | 1 | 0 | 1 | 31 | 105 | 6 | 16 | .234 | .305 | .330 | .635 | .234 | .096 | .304 | 7.62 | 23.81 | 3.13 | 94.00 | 2011- 6- 188-CLE | premium | premium | premium | AAA | 2011-2016 | 2016 | |
| 9 | Eric Stamets | 24 | SS | R | 67* | 22 | 73 | 7 | 12 | 0 | 1 | 1 | 9 | 1 | 0 | 3 | 28 | 3 | 1 | 3 | 0 | 0 | 17 | 83 | 2 | 10 | .164 | .220 | .233 | .453 | .123 | .069 | .234 | 3.61 | 33.73 | 9.33 | 73.00 | 2012- 6- 207-ANA | premium | premium | premium | MLB | 2019-2019 | 2010-2022 | 2016 |
| 7 | Tyler Naquin | 25 | CF | L | 17 | 70 | 6 | 20 | 3 | 1 | 1 | 8 | 1 | 2 | 8 | 15 | 0 | 0 | 1 | 0 | 1 | 28 | 79 | 5 | 15 | .286 | .354 | .400 | .754 | .214 | .114 | .345 | 10.13 | 18.99 | 1.88 | 70.00 | 2012- 1- 15-CLE | premium | premium | premium | MLB | 2016-2023 | 2010-2025 | 2016 | |
| 45 | Anthony Recker | 32 | C | R | 111 | 19 | 61 | 10 | 15 | 5 | 0 | 2 | 10 | 1 | 0 | 14 | 17 | 1 | 0 | 0 | 0 | 1 | 26 | 76 | 7 | 8 | .246 | .395 | .426 | .821 | .426 | .180 | .310 | 18.42 | 22.37 | 1.21 | 30.50 | 2005- 18- 551-OAK | premium | premium | premium | MLB | 2011-2017 | 2002-2018 | 2016 |
| 8 | Jordan Smith | 25 | RF | L | 17 | 53 | 6 | 10 | 3 | 0 | 1 | 3 | 2 | 0 | 5 | 13 | 0 | 1 | 0 | 1 | 1 | 16 | 59 | 4 | 6 | .189 | .259 | .302 | .561 | .245 | .113 | .231 | 8.47 | 22.03 | 2.60 | 53.00 | 2011- 9- 278-CLE | premium | premium | premium | AAA | 2012-2018 | 2016 | ||
| 11 | Todd Hankins | 25 | 3B-LF | R | 7 | 28 | 7 | 9 | 1 | 1 | 0 | 2 | 3 | 0 | 1 | 11 | 0 | 0 | 0 | 0 | 0 | 12 | 29 | 2 | 7 | .321 | .345 | .429 | .774 | .250 | .108 | .529 | 3.45 | 37.93 | 11.00 | 0.00 | 2011- 15- 458-CLE | premium | premium | premium | AAA | 2010-2018 | 2016 | ||
| 8 | Abraham Almonte | 27 | CF | B | 7 | 27 | 6 | 12 | 2 | 1 | 1 | 4 | 2 | 0 | 5 | 4 | 1 | 0 | 0 | 0 | 1 | 19 | 33 | 4 | 8 | .444 | .545 | .704 | 1.249 | .519 | .260 | .500 | 15.15 | 12.12 | 0.80 | 27.00 | 2005- UDFA -NYA | premium | premium | premium | MLB | 2013-2023 | 2007-2025 | 2016 | |
| 8 | Clint Frazier | 21 | RF-LF | R | 93* | 5 | 21 | 2 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 7 | 21 | 1 | 4 | .238 | .238 | .333 | .571 | .095 | .095 | .333 | 0.00 | 28.57 | 0.00 | 0.00 | 2013- 1- 5-CLE | premium | premium | premium | MLB | 2017-2023 | 2013-2024 | 2016 |
| 10 | Jeremy Lucas | 25 | 1B-C | R | 4 | 16 | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 5 | 16 | 1 | 3 | .250 | .250 | .313 | .563 | .063 | .063 | .364 | 0.00 | 31.25 | 0.00 | 0.00 | 2012- 12- 383-CLE | premium | premium | premium | AAA | 2010-2017 | 2016 | ||
| 25 | Ordomar Valdez | 22 | 3B-2B | B | 3 | 9 | 2 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 10 | 0 | 1 | .111 | .100 | .111 | .211 | .000 | .000 | .125 | 0.00 | 20.00 | 0.00 | 0.00 | 2010- UDFA -CLE | premium | premium | premium | AAA | 2011-2017 | 2016 | ||
| 50 | Michael Brantley | 29 | LF | L | 3 | 9 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 11 | 1 | 0 | .111 | .182 | .222 | .404 | .222 | .111 | .111 | 9.09 | 9.09 | 1.00 | 0.00 | 2005- 7- 205-MIL | premium | premium | premium | MLB | 2009-2023 | 2005-2023 | 2016 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 2 | Lonnie Chisenhall | 27 | RF | L | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 11 | 0 | 0 | .000 | .182 | .000 | .182 | .250 | .000 | .000 | 18.18 | 27.27 | 1.50 | 0.00 | 2008- 1- 29-CLE | premium | premium | premium | MLB | 2011-2018 | 2007-2019 | 2016 | |
| 7 | Bobby Ison | 22 | LF-CF | L | 2 | 7 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 | 1 | .143 | .143 | .143 | .286 | .000 | .000 | .333 | 0.00 | 57.14 | 0.00 | 0.00 | 2014- 21- 638-CLE | premium | premium | premium | AAA | 2012-2016 | 2016 | ||
| 10 | Alex Lavisky | 25 | C | R | 2 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 8 | 0 | 1 | .167 | .286 | .167 | .453 | .167 | .000 | .167 | 12.50 | 0.00 | 0.00 | 0.00 | 2010- 8- 240-CLE | premium | premium | premium | AAA | 2010-2016 | 2016 | ||
| 8 | Roberto Perez | 27 | C | R | 2 | 5 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 7 | 1 | 1 | .400 | .571 | .600 | 1.171 | .600 | .200 | .500 | 28.57 | 14.29 | 0.50 | 0.00 | 2008- 33-1011-CLE | premium | premium | premium | MLB | 2014-2023 | 2009-2025 | 2016 | |
| 49 | Alex Monsalve | 24 | C | R | 1 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 0 | 1 | .250 | .250 | .250 | .500 | .000 | .000 | .333 | 0.00 | 25.00 | 0.00 | 0.00 | 2008- UDFA -CLE | premium | premium | premium | AAA | 2010-2017 | 2016 | ||
| 8 | Ivan Castillo | 21 | SS-2B | B | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 25.00 | 0.00 | 0.00 | 2011- UDFA -CLE | premium | premium | premium | MLB | 2021-2021 | 2012-2025 | 2016 | |
| Totals: | 1337 | 4883 | 631 | 1270 | 253 | 21 | 129 | 592 | 62 | 27 | 400 | 1088 | 52 | 39 | 41 | 13 | 104 | 1952 | 5415 | 403 | 867 | .260 | .320 | .400 | .720 | .229 | .140 | .308 | 7.39 | 20.09 | 2.72 | 37.85 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 39 | Mike Clevinger | 25 | R | 11 | 1 | 3.00 | 17 | 17 | 1 | 0 | 0 | 0 | 0 | 93.0 | 78 | 32 | 31 | 8 | 35 | 97 | 8 | 0 | 1 | 1.22 | 7.55 | 0.77 | 3.39 | 9.39 | 3.10 | 2.77 | 2011- 4- 135-ANA | premium | premium | premium | MLB | 2016-2025 | 2010-2025 | 2016 |
| 28 | Adam Plutko | 24 | R | 6 | 5 | 4.10 | 15 | 15 | 0 | 0 | 0 | 0 | 0 | 90.0 | 87 | 42 | 41 | 8 | 34 | 67 | 1 | 1 | 0 | 1.34 | 8.70 | 0.80 | 3.40 | 6.70 | 4.20 | 1.97 | 2013- 11- 321-CLE | premium | premium | premium | MLB | 2016-2021 | 2011-2025 | 2016 |
| 38 | Will Roberts | 25 | R | 6 | 6 | 4.70 | 16 | 15 | 0 | 0 | 1 | 0 | 0 | 88.0 | 89 | 46 | 46 | 12 | 38 | 42 | 6 | 0 | 3 | 1.44 | 9.10 | 1.23 | 3.89 | 4.30 | 4.70 | 1.11 | 2011- 5- 158-CLE | premium | premium | premium | AAA | 2009-2016 | 2016 | |
| 36 | TJ House | 26 | L | 5 | 3 | 3.98 | 33 | 12 | 0 | 0 | 21 | 3 | 1 | 72.1 | 89 | 44 | 32 | 6 | 43 | 50 | 5 | 0 | 2 | 1.82 | 11.07 | 0.75 | 5.35 | 6.22 | 5.47 | 1.16 | 2008- 16- 501-CLE | premium | premium | premium | MLB | 2014-2017 | 2009-2019 | 2016 |
| 35 | Josh Martin | 26 | R | 2 | 5 | 3.41 | 47 | 0 | 0 | 0 | 47 | 15 | 3 | 66.0 | 57 | 26 | 25 | 4 | 23 | 60 | 4 | 0 | 4 | 1.21 | 7.77 | 0.55 | 3.14 | 8.18 | 3.55 | 2.61 | 2012- 10- 323-CLE | premium | premium | premium | AAA | 2009-2023 | 2016 | |
| 41 | Ross Detwiler | 30 | L | 2 | 4 | 4.60 | 12 | 12 | 0 | 0 | 0 | 0 | 0 | 62.2 | 64 | 33 | 32 | 6 | 21 | 41 | 3 | 0 | 3 | 1.36 | 9.19 | 0.86 | 3.02 | 5.89 | 4.74 | 1.95 | 2007- 1- 6-WAS | premium | premium | premium | MLB | 2007-2022 | 2005-2022 | 2016 |
| 8 | Nick Pasquale | 25 | R | 1 | 0 | 0.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 6.2 | 2 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 2 | 0.75 | 2.70 | 0.00 | 4.05 | 2.70 | 0.00 | 0.67 | 2012- 20- 623-CLE | premium | premium | premium | AAA | 2012-2018 | 2016 | |
| 28 | Michael Peoples | 24 | R | 1 | 0 | 3.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 6.0 | 4 | 2 | 2 | 0 | 2 | 3 | 0 | 0 | 0 | 1.00 | 6.00 | 0.00 | 3.00 | 4.50 | 3.00 | 1.50 | 2012- 14- 443-CLE | premium | premium | premium | AAA | 2012-2022 | 2016 | |
| 34 | Shawn Morimando | 23 | L | 5 | 2 | 3.51 | 11 | 11 | 0 | 0 | 0 | 0 | 0 | 59.0 | 64 | 26 | 23 | 5 | 21 | 46 | 1 | 0 | 2 | 1.44 | 9.76 | 0.76 | 3.20 | 7.02 | 3.97 | 2.19 | 2011- 19- 578-CLE | premium | premium | premium | MLB | 2016-2021 | 2011-2021 | 2016 |
| 40 | Jeff Johnson | 26 | R | 4 | 1 | 2.87 | 48 | 0 | 0 | 0 | 48 | 13 | 2 | 53.1 | 45 | 22 | 17 | 3 | 24 | 57 | 6 | 0 | 3 | 1.29 | 7.59 | 0.51 | 4.05 | 9.62 | 3.71 | 2.38 | 2011- 10- 308-CLE | premium | premium | premium | AAA | 2009-2024 | 2016 | |
| 11 | Cole Sulser | 26 | R | 0 | 0 | 1.69 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 5.1 | 3 | 1 | 1 | 0 | 0 | 7 | 0 | 0 | 0 | 0.56 | 5.06 | 0.00 | 0.00 | 11.81 | 1.69 | 0.00 | 2013- 25- 741-CLE | premium | premium | premium | MLB | 2019-2025 | 2009-2025 | 2016 |
| 22 | D.J. Brown | 25 | R | 0 | 0 | 7.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5.0 | 9 | 4 | 4 | 2 | 3 | 3 | 0 | 0 | 0 | 2.40 | 16.20 | 3.60 | 5.40 | 5.40 | 7.20 | 1.00 | 2012- 39-1193-CLE | premium | premium | premium | AAA | 2010-2018 | 2016 | |
| 10 | David Speer | 23 | L | 1 | 0 | 10.80 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 5.0 | 9 | 6 | 6 | 0 | 2 | 3 | 1 | 0 | 0 | 2.20 | 16.20 | 0.00 | 3.60 | 5.40 | 10.80 | 1.50 | 2014- 27- 818-CLE | premium | premium | premium | AAA | 2011-2019 | 2016 | |
| 43 | Shawn Armstrong | 25 | R | 3 | 1 | 1.84 | 47 | 0 | 0 | 0 | 47 | 22 | 9 | 49.0 | 27 | 11 | 10 | 0 | 29 | 72 | 3 | 0 | 3 | 1.14 | 4.96 | 0.00 | 5.33 | 13.22 | 2.02 | 2.48 | 2011- 18- 548-CLE | premium | premium | premium | MLB | 2015-2025 | 2009-2025 | 2016 |
| 46 | Jarrett Grube | 34 | R | 0 | 3 | 4.43 | 11 | 7 | 0 | 0 | 4 | 0 | 0 | 44.2 | 48 | 25 | 22 | 7 | 10 | 37 | 3 | 0 | 3 | 1.30 | 9.67 | 1.41 | 2.01 | 7.46 | 5.04 | 3.70 | 2004- 10- 290-COL | premium | premium | premium | MLB | 2014-2014 | 2003-2017 | 2016 |
| 39 | Shawn Haviland | 30 | R | 2 | 2 | 3.40 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 42.1 | 41 | 16 | 16 | 4 | 10 | 30 | 1 | 0 | 0 | 1.20 | 8.72 | 0.85 | 2.13 | 6.38 | 3.40 | 3.00 | 2008- 33- 994-OAK | premium | premium | premium | AAA | 2005-2017 | 2016 | |
| 22 | Austin Adams | 29 | R | 2 | 4 | 4.54 | 34 | 0 | 0 | 0 | 34 | 25 | 8 | 37.2 | 44 | 21 | 19 | 1 | 9 | 41 | 6 | 1 | 1 | 1.41 | 10.51 | 0.24 | 2.15 | 9.80 | 5.02 | 4.56 | 2009- 5- 155-CLE | premium | premium | premium | MLB | 2014-2019 | 2009-2022 | 2016 |
| 45 | Cody Anderson | 25 | R | 0 | 2 | 3.62 | 13 | 6 | 0 | 0 | 7 | 4 | 1 | 32.1 | 32 | 15 | 13 | 4 | 10 | 40 | 2 | 1 | 2 | 1.30 | 8.91 | 1.11 | 2.78 | 11.13 | 4.18 | 4.00 | 2011- 14- 428-CLE | premium | premium | premium | MLB | 2015-2019 | 2011-2019 | 2016 |
| 8 | Kyle Crockett | 24 | L | 1 | 1 | 3.90 | 29 | 0 | 0 | 0 | 29 | 3 | 0 | 30.0 | 29 | 13 | 13 | 2 | 11 | 26 | 0 | 0 | 1 | 1.33 | 8.70 | 0.60 | 3.30 | 7.80 | 3.90 | 2.36 | 2013- 4- 111-CLE | premium | premium | premium | MLB | 2014-2018 | 2011-2018 | 2016 |
| 41 | Jordan Cooper | 27 | R | 1 | 0 | 3.00 | 3 | 0 | 0 | 0 | 3 | 1 | 0 | 3.0 | 3 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 1.33 | 9.00 | 0.00 | 3.00 | 6.00 | 3.00 | 2.00 | 2010- 9- 270-CLE | premium | premium | premium | AAA | 2009-2018 | 2016 | |
| 10 | Perci Garner | 27 | R | 2 | 0 | 1.63 | 18 | 0 | 0 | 0 | 18 | 9 | 5 | 27.2 | 15 | 5 | 5 | 1 | 11 | 23 | 1 | 0 | 0 | 0.94 | 4.88 | 0.33 | 3.58 | 7.48 | 1.63 | 2.09 | 2010- 2- 77-PHI | premium | premium | premium | MLB | 2016-2016 | 2009-2017 | 2016 |
| 44 | Ben Heller | 24 | R | 2 | 2 | 2.49 | 28 | 0 | 0 | 0 | 28 | 13 | 5 | 25.1 | 20 | 7 | 7 | 1 | 7 | 25 | 2 | 1 | 4 | 1.07 | 7.11 | 0.36 | 2.49 | 8.88 | 2.49 | 3.57 | 2013- 22- 651-CLE | premium | premium | premium | MLB | 2016-2024 | 2013-2024 | 2016 |
| 46 | Nick Maronde | 26 | L | 0 | 0 | 4.24 | 17 | 2 | 0 | 0 | 15 | 3 | 1 | 23.1 | 25 | 12 | 11 | 1 | 11 | 16 | 0 | 0 | 0 | 1.54 | 9.64 | 0.39 | 4.24 | 6.17 | 4.63 | 1.45 | 2011- 3- 104-ANA | premium | premium | premium | MLB | 2012-2014 | 2009-2016 | 2016 |
| 48 | Joe Colon | 26 | R | 0 | 1 | 0.82 | 20 | 0 | 0 | 0 | 20 | 5 | 0 | 22.0 | 8 | 4 | 2 | 0 | 12 | 21 | 1 | 0 | 1 | 0.91 | 3.27 | 0.00 | 4.91 | 8.59 | 1.64 | 1.75 | 2009- 12- 365-CLE | premium | premium | premium | MLB | 2016-2016 | 2009-2018 | 2016 |
| 36 | Cam Hill | 22 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2.2 | 2 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1.12 | 6.75 | 0.00 | 3.37 | 6.75 | 0.00 | 2.00 | 2014- 17- 518-CLE | premium | premium | premium | MLB | 2020-2020 | 2013-2024 | 2016 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 15 | Yhoxian Medina | 26 | R | 0 | 1 | 7.71 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 2.1 | 2 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1.29 | 7.71 | 3.86 | 3.86 | 0.00 | 7.71 | 0.00 | 2011- 38-1148-CLE | premium | premium | premium | AAA | 2012-2019 | 2016 | |
| 8 | Matt Whitehouse | 25 | L | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2.1 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 1 | 0 | 1.29 | 0.00 | 0.00 | 11.57 | 11.57 | 0.00 | 1.00 | 2013- 19- 561-CLE | premium | premium | premium | AAA | 2010-2019 | 2016 | |
| 45 | Zach McAllister | 28 | R | 0 | 0 | 4.50 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 2.0 | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1.50 | 13.50 | 0.00 | 0.00 | 4.50 | 4.50 | 0.00 | 2006- 3- 104-NYA | premium | premium | premium | MLB | 2011-2023 | 2006-2023 | 2016 |
| 0 | Tom Gorzelanny | 33 | L | 1 | 1 | 3.37 | 19 | 0 | 0 | 0 | 19 | 3 | 1 | 18.2 | 13 | 8 | 7 | 0 | 11 | 19 | 1 | 0 | 1 | 1.29 | 6.27 | 0.00 | 5.30 | 9.16 | 3.86 | 1.73 | 2003- 2- 45-PIT | premium | premium | premium | MLB | 2005-2016 | 2002-2017 | 2016 |
| 50 | Tommy Hunter | 29 | R | 2 | 1 | 3.00 | 14 | 2 | 0 | 0 | 12 | 2 | 1 | 15.0 | 14 | 5 | 5 | 2 | 2 | 10 | 0 | 0 | 0 | 1.07 | 8.40 | 1.20 | 1.20 | 6.00 | 3.00 | 5.00 | 2007- 1- 54-TEX | premium | premium | premium | MLB | 2008-2023 | 2006-2023 | 2016 |
| 12 | Ryan Merritt | 24 | L | 11 | 8 | 3.70 | 24 | 24 | 2 | 1 | 0 | 0 | 0 | 143.1 | 156 | 67 | 59 | 15 | 23 | 92 | 2 | 0 | 6 | 1.25 | 9.80 | 0.94 | 1.44 | 5.78 | 4.21 | 4.00 | 2011- 16- 488-CLE | premium | premium | premium | MLB | 2016-2017 | 2011-2019 | 2016 |
| 44 | Craig Stammen | 32 | R | 0 | 3 | 5.54 | 10 | 0 | 0 | 0 | 10 | 5 | 0 | 13.0 | 16 | 8 | 8 | 2 | 2 | 11 | 0 | 0 | 0 | 1.38 | 11.08 | 1.38 | 1.38 | 7.62 | 5.54 | 5.50 | 2005- 12- 354-WAS | premium | premium | premium | MLB | 2009-2022 | 2003-2022 | 2016 |
| 58 | Felipe Paulino | 32 | R | 1 | 1 | 2.77 | 10 | 0 | 0 | 0 | 10 | 2 | 0 | 13.0 | 5 | 5 | 4 | 1 | 5 | 10 | 2 | 0 | 0 | 0.77 | 3.46 | 0.69 | 3.46 | 6.92 | 3.46 | 2.00 | 2001- UDFA -HOU | premium | premium | premium | MLB | 2007-2014 | 2003-2019 | 2016 |
| 17 | Toru Murata | 31 | R | 9 | 4 | 3.78 | 33 | 10 | 0 | 0 | 23 | 7 | 4 | 102.1 | 102 | 47 | 43 | 7 | 24 | 62 | 5 | 0 | 3 | 1.23 | 8.97 | 0.62 | 2.11 | 5.45 | 4.13 | 2.58 | 2010- UDFA -CLE | premium | premium | premium | MLB | 2015-2015 | 2011-2021 | 2016 |
| 41 | Tyler Olson | 26 | L | 1 | 0 | 5.91 | 9 | 0 | 0 | 0 | 9 | 3 | 0 | 10.2 | 12 | 9 | 7 | 1 | 6 | 10 | 1 | 0 | 1 | 1.69 | 10.12 | 0.84 | 5.06 | 8.44 | 7.59 | 1.67 | 2013- 7- 207-SEA | premium | premium | premium | MLB | 2015-2019 | 2009-2021 | 2016 |
| 38 | Colt Hynes | 31 | L | 0 | 0 | 13.50 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.1 | 3 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 2.25 | 20.25 | 6.75 | 0.00 | 6.75 | 13.50 | 0.00 | 2007- 31- 956-SDN | premium | premium | premium | MLB | 2013-2015 | 2006-2017 | 2016 |
| 12 | Argenis Angulo | 22 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.1 | 1 | 0 | 0 | 0 | 3 | 3 | 1 | 0 | 0 | 3.00 | 6.75 | 0.00 | 20.25 | 20.25 | 0.00 | 1.00 | 2014- 19- 578-CLE | premium | premium | premium | AAA | 2013-2022 | 2016 | |
| 45 | Anthony Recker | 32 | R | 0 | 0 | 54.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0.2 | 5 | 4 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 10.50 | 67.50 | 0.00 | 27.00 | 0.00 | 54.00 | 0.00 | 2005- 18- 551-OAK | premium | premium | premium | MLB | 2011-2017 | 2002-2018 | 2016 |
| Totals: | 82 | 62 | 3.67 | 561 | 144 | 3 | 1 | 141 | 417 | 41 | 1278.1 | 1226 | 572 | 521 | 105 | 453 | 1035 | 66 | 5 | 46 | 1.31 | 8.63 | 0.74 | 3.19 | 7.29 | 4.03 | 2.28 | premium | premium | premium |