| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 16 | Marco Scutaro | 34 | SS | R | 99 | 150 | 632 | 92 | 174 | 38 | 0 | 11 | 56 | 5 | 4 | 53 | 71 | 3 | 4 | 3 | 1 | 13 | 245 | 695 | 49 | 125 | .275 | .333 | .388 | .721 | .198 | .113 | .295 | 7.63 | 10.22 | 1.34 | 57.45 | 1994- UDFA -CLE | premium | premium | premium | MLB | 2002-2014 | 1996-2014 | 2010 |
| 29 | Adrian Beltre | 31 | 3B | R | 122 | 154 | 589 | 84 | 189 | 49 | 2 | 28 | 102 | 2 | 1 | 40 | 82 | 5 | 0 | 7 | 10 | 25 | 326 | 641 | 79 | 110 | .321 | .365 | .553 | .918 | .302 | .232 | .331 | 6.24 | 12.79 | 2.05 | 21.04 | 1994- UDFA -LAN | premium | premium | premium | MLB | 1998-2018 | 1996-2018 | 2010 |
| 34 | David Ortiz | 34 | DH | L | 119 | 145 | 518 | 86 | 140 | 36 | 1 | 32 | 102 | 0 | 1 | 82 | 145 | 2 | 0 | 4 | 14 | 12 | 274 | 606 | 69 | 71 | .270 | .370 | .529 | .899 | .415 | .259 | .313 | 13.53 | 23.93 | 1.77 | 16.19 | 1992- UDFA -SEA | premium | premium | premium | MLB | 1997-2016 | 1994-2016 | 2010 |
| 41 | Victor Martinez | 31 | C | B | 114 | 127 | 493 | 64 | 149 | 32 | 1 | 20 | 79 | 1 | 0 | 40 | 52 | 0 | 0 | 5 | 5 | 17 | 243 | 538 | 53 | 96 | .302 | .351 | .493 | .844 | .274 | .191 | .303 | 7.43 | 9.67 | 1.30 | 24.65 | 1996- UDFA -CLE | premium | premium | premium | MLB | 2002-2018 | 1999-2018 | 2010 |
| 7 | J.D. Drew | 34 | RF | L | 108 | 139 | 478 | 69 | 122 | 24 | 2 | 22 | 68 | 3 | 1 | 60 | 105 | 4 | 0 | 4 | 3 | 12 | 216 | 546 | 48 | 74 | .255 | .341 | .452 | .793 | .326 | .197 | .282 | 10.99 | 19.23 | 1.75 | 21.73 | 1998- 1- 5-SLN | premium | premium | premium | MLB | 1998-2011 | 1995-2011 | 2010 |
| 20 | Kevin Youkilis | 31 | 1B | R | 131 | 102 | 362 | 77 | 111 | 26 | 5 | 19 | 62 | 4 | 1 | 58 | 67 | 10 | 0 | 5 | 3 | 4 | 204 | 435 | 50 | 61 | .307 | .411 | .564 | .975 | .425 | .257 | .327 | 13.33 | 15.40 | 1.16 | 19.05 | 2001- 8- 243-BOS | premium | premium | premium | MLB | 2004-2013 | 1998-2014 | 2010 |
| 22 | Bill Hall | 30 | LF-2B | R | 107 | 119 | 344 | 44 | 85 | 16 | 1 | 18 | 46 | 9 | 1 | 34 | 104 | 1 | 2 | 1 | 0 | 4 | 157 | 382 | 35 | 50 | .247 | .316 | .456 | .772 | .331 | .209 | .300 | 8.90 | 27.23 | 3.06 | 19.11 | 1998- 6- 176-MIL | premium | premium | premium | MLB | 2002-2012 | 1998-2014 | 2010 |
| 54 | Darnell McDonald | 31 | CF | R | 106 | 117 | 319 | 40 | 86 | 18 | 3 | 9 | 34 | 9 | 1 | 30 | 85 | 2 | 12 | 0 | 1 | 5 | 137 | 363 | 30 | 56 | .270 | .336 | .429 | .765 | .279 | .159 | .342 | 8.26 | 23.42 | 2.83 | 35.44 | 1997- 1- 26-BAL | premium | premium | premium | MLB | 2004-2013 | 1998-2013 | 2010 |
| 15 | Dustin Pedroia | 26 | 2B | R | 117 | 75 | 302 | 53 | 87 | 24 | 1 | 12 | 41 | 9 | 1 | 37 | 38 | 4 | 2 | 6 | 1 | 7 | 149 | 351 | 37 | 50 | .288 | .367 | .493 | .860 | .354 | .205 | .291 | 10.54 | 10.83 | 1.03 | 25.17 | 2004- 2- 65-BOS | premium | premium | premium | MLB | 2006-2019 | 2002-2019 | 2010 |
| 25 | Mike Lowell | 36 | 1B | R | 93 | 73 | 218 | 23 | 52 | 13 | 0 | 5 | 26 | 0 | 0 | 23 | 34 | 0 | 0 | 3 | 1 | 9 | 80 | 244 | 18 | 34 | .239 | .307 | .367 | .674 | .234 | .128 | .258 | 9.43 | 13.93 | 1.48 | 43.60 | 1995- 20- 562-NYA | premium | premium | premium | MLB | 1998-2010 | 1993-2010 | 2010 |
| 12 | Jed Lowrie | 26 | 2B-SS | B | 123* | 55 | 171 | 31 | 49 | 14 | 0 | 9 | 24 | 1 | 1 | 25 | 25 | 1 | 0 | 0 | 0 | 2 | 90 | 197 | 23 | 26 | .287 | .381 | .526 | .907 | .386 | .239 | .292 | 12.69 | 12.69 | 1.00 | 19.00 | 2005- 1- 45-BOS | premium | premium | premium | MLB | 2008-2022 | 2003-2022 | 2010 |
| 55 | Ryan Kalish | 22 | CF | L | 100* | 53 | 163 | 26 | 41 | 11 | 1 | 4 | 24 | 10 | 1 | 12 | 38 | 1 | 2 | 1 | 0 | 5 | 66 | 179 | 16 | 25 | .252 | .305 | .405 | .710 | .282 | .153 | .303 | 6.70 | 21.23 | 3.17 | 40.75 | 2006- 9- 283-BOS | premium | premium | premium | MLB | 2010-2016 | 2006-2016 | 2010 |
| 23 | Mike Cameron | 37 | CF | R | 100* | 48 | 162 | 24 | 42 | 11 | 0 | 4 | 15 | 0 | 1 | 14 | 44 | 3 | 0 | 1 | 0 | 3 | 65 | 180 | 15 | 27 | .259 | .328 | .401 | .729 | .222 | .142 | .330 | 7.78 | 24.44 | 3.14 | 40.50 | 1991- 18- 488-CHA | premium | premium | premium | MLB | 1995-2011 | 1991-2011 | 2010 |
| 60 | Daniel Nava | 27 | LF | B | 100* | 60 | 161 | 23 | 39 | 14 | 1 | 1 | 26 | 1 | 1 | 19 | 46 | 8 | 0 | 0 | 1 | 5 | 58 | 188 | 16 | 23 | .242 | .351 | .360 | .711 | .236 | .118 | .333 | 10.11 | 24.47 | 2.42 | 161.00 | 2008- UDFA -BOS | premium | premium | premium | MLB | 2010-2017 | 2006-2019 | 2010 |
| 32 | Jeremy Hermida | 26 | LF | L | 86 | 52 | 158 | 14 | 32 | 8 | 0 | 5 | 27 | 1 | 0 | 12 | 45 | 0 | 0 | 1 | 0 | 0 | 55 | 171 | 13 | 19 | .203 | .257 | .348 | .605 | .228 | .145 | .248 | 7.02 | 26.32 | 3.75 | 31.60 | 2002- 1- 11-MIA | premium | premium | premium | MLB | 2005-2012 | 2002-2015 | 2010 |
| 33 | Jason Varitek | 38 | C | B | 102* | 39 | 112 | 18 | 26 | 6 | 0 | 7 | 16 | 0 | 0 | 10 | 35 | 0 | 0 | 1 | 2 | 1 | 53 | 123 | 13 | 13 | .232 | .293 | .473 | .766 | .330 | .241 | .268 | 8.13 | 28.46 | 3.50 | 16.00 | 1994- 1- 14-SEA | premium | premium | premium | MLB | 1997-2011 | 1991-2011 | 2010 |
| 3 | Eric Patterson | 27 | LF-CF | L | 95* | 45 | 84 | 13 | 19 | 3 | 3 | 2 | 7 | 5 | 1 | 7 | 31 | 1 | 1 | 0 | 0 | 1 | 34 | 93 | 8 | 11 | .226 | .293 | .405 | .698 | .310 | .179 | .333 | 7.53 | 33.33 | 4.43 | 42.00 | 2004- 8- 246-CHN | premium | premium | premium | MLB | 2007-2011 | 2002-2015 | 2010 |
| 2 | Jacoby Ellsbury | 26 | CF | L | 18 | 78 | 10 | 15 | 4 | 0 | 0 | 5 | 7 | 1 | 4 | 9 | 1 | 0 | 0 | 0 | 0 | 19 | 83 | 4 | 11 | .192 | .241 | .244 | .485 | .179 | .052 | .217 | 4.82 | 10.84 | 2.25 | 0.00 | 2005- 1- 23-BOS | premium | premium | premium | MLB | 2007-2017 | 2003-2017 | 2010 | |
| 46 | Josh Reddick | 23 | RF | L | 29 | 62 | 5 | 12 | 3 | 1 | 1 | 5 | 1 | 0 | 1 | 15 | 0 | 0 | 0 | 0 | 1 | 20 | 63 | 5 | 7 | .194 | .206 | .323 | .529 | .161 | .129 | .239 | 1.59 | 23.81 | 15.00 | 62.00 | 2006- 17- 523-BOS | premium | premium | premium | MLB | 2009-2021 | 2007-2022 | 2010 | |
| 36 | Kevin Cash | 32 | C | R | 70* | 29 | 60 | 1 | 8 | 1 | 0 | 0 | 1 | 0 | 0 | 6 | 16 | 1 | 1 | 0 | 0 | 2 | 9 | 68 | 1 | 7 | .133 | .224 | .150 | .374 | .117 | .017 | .182 | 8.82 | 23.53 | 2.67 | 0.00 | 1999- UDFA -TOR | premium | premium | premium | MLB | 2002-2010 | 1997-2011 | 2010 |
| 56 | Yamaico Navarro | 22 | SS | R | 20 | 42 | 4 | 6 | 0 | 0 | 0 | 5 | 0 | 0 | 2 | 17 | 0 | 0 | 2 | 1 | 0 | 6 | 46 | 0 | 6 | .143 | .174 | .143 | .317 | .048 | .000 | .222 | 4.35 | 36.96 | 8.50 | 0.00 | 2005- UDFA -BOS | premium | premium | premium | MLB | 2010-2013 | 2007-2025 | 2010 | |
| 44 | Lars Anderson | 22 | 1B | L | 18 | 35 | 4 | 7 | 1 | 0 | 0 | 4 | 0 | 0 | 7 | 8 | 0 | 0 | 1 | 0 | 1 | 8 | 43 | 1 | 6 | .200 | .326 | .229 | .555 | .229 | .029 | .250 | 16.28 | 18.60 | 1.14 | 0.00 | 2006- 18- 553-BOS | premium | premium | premium | MLB | 2010-2012 | 2007-2016 | 2010 | |
| 44 | Jonathan Van Every | 30 | CF-RF | L | 21 | 19 | 6 | 4 | 1 | 0 | 1 | 1 | 0 | 0 | 2 | 9 | 0 | 0 | 0 | 0 | 0 | 8 | 21 | 2 | 2 | .211 | .286 | .421 | .707 | .316 | .210 | .333 | 9.52 | 42.86 | 4.50 | 19.00 | 2000- 29- 876-CLE | premium | premium | premium | MLB | 2008-2010 | 2001-2011 | 2010 | |
| 39 | Jarrod Saltalamacchia | 25 | C | B | 10 | 19 | 2 | 3 | 3 | 0 | 0 | 1 | 0 | 0 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 6 | 25 | 3 | 0 | .158 | .360 | .316 | .676 | .474 | .158 | .200 | 24.00 | 16.00 | 0.67 | 0.00 | 2003- 1- 36-ATL | premium | premium | premium | MLB | 2007-2018 | 2003-2018 | 2010 | |
| 32 | Felipe Lopez | 30 | 2B-3B | B | 92 | 4 | 15 | 2 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 7 | 16 | 1 | 3 | .267 | .313 | .467 | .780 | .267 | .200 | .300 | 6.25 | 25.00 | 4.00 | 15.00 | 1998- 1- 8-TOR | premium | premium | premium | MLB | 2001-2011 | 1998-2011 | 2010 |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 68 | Dusty Brown | 28 | C | R | 7 | 12 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4 | 12 | 1 | 2 | .250 | .250 | .333 | .583 | .083 | .083 | .300 | 0.00 | 16.67 | 0.00 | 0.00 | 2000- 35-1052-BOS | premium | premium | premium | MLB | 2009-2011 | 2001-2014 | 2010 | |
| 44 | Gustavo Molina | 28 | C | R | 4 | 7 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 | 1 | .143 | .143 | .143 | .286 | .000 | .000 | .200 | 0.00 | 28.57 | 0.00 | 0.00 | 2000- UDFA -CHA | premium | premium | premium | MLB | 2007-2011 | 2000-2017 | 2010 | |
| 30 | Ryan Shealy | 30 | 1B | R | 5 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 28.57 | 0.00 | 0.00 | 2002- 11- 321-COL | premium | premium | premium | MLB | 2005-2010 | 1999-2011 | 2010 | |
| 40 | John Lackey | 31 | P | R | 3 | 5 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 6 | 1 | 1 | .400 | .400 | .600 | 1.000 | .200 | .200 | .500 | 0.00 | 16.67 | 0.00 | 0.00 | 1999- 2- 68-ANA | premium | premium | premium | MLB | 2002-2017 | 1998-2017 | 2010 | |
| 13 | Niuman Romero | 25 | 2B-1B | B | 2 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2002- UDFA -CLE | premium | premium | premium | MLB | 2009-2010 | 2005-2022 | 2010 | |
| 49 | Tim Wakefield | 43 | P | R | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .200 | .000 | .200 | .250 | .000 | .000 | 14.29 | 28.57 | 2.00 | 0.00 | 1988- 8- 200-PIT | premium | premium | premium | MLB | 1992-2011 | 1988-2011 | 2010 | |
| 18 | Daisuke Matsuzaka | 29 | P | R | 2 | 4 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 5 | 0 | 2 | .500 | .500 | .500 | 1.000 | .000 | .000 | .500 | 0.00 | 0.00 | 0.00 | 0.00 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2014 | 1999-2021 | 2010 | |
| 13 | Angel Sanchez | 26 | SS | R | 91 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2001- 11- 325-KCA | premium | premium | premium | MLB | 2006-2013 | 2001-2016 | 2010 |
| 31 | Jon Lester | 26 | P | L | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .200 | .000 | .200 | .333 | .000 | .000 | 16.67 | 33.33 | 2.00 | 0.00 | 2002- 2- 57-BOS | premium | premium | premium | MLB | 2006-2021 | 2002-2021 | 2010 | |
| 11 | Clay Buchholz | 25 | P | L | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1.000 | 1.000 | 1.000 | 2.000 | .000 | .000 | 1.000 | 0.00 | 0.00 | 0.00 | 0.00 | 2005- 1- 42-BOS | premium | premium | premium | MLB | 2007-2019 | 2004-2019 | 2010 | |
| Totals: | 1731 | 5646 | 818 | 1511 | 358 | 22 | 211 | 782 | 68 | 17 | 587 | 1140 | 47 | 29 | 46 | 43 | 130 | 2546 | 6355 | 591 | 920 | .268 | .339 | .451 | .790 | .296 | .183 | .299 | 9.24 | 17.94 | 1.94 | 26.76 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 46 | Joe Nelson | 35 | R | 0 | 0 | 9.72 | 8 | 0 | 0 | 0 | 8 | 4 | 0 | 8.1 | 14 | 9 | 9 | 2 | 6 | 9 | 0 | 0 | 0 | 2.40 | 15.12 | 2.16 | 6.48 | 9.72 | 9.72 | 1.50 | 1996- 4- 122-ATL | premium | premium | premium | MLB | 2001-2010 | 1996-2010 | 2010 |
| 51 | Daniel Bard | 25 | R | 1 | 2 | 1.93 | 73 | 0 | 0 | 0 | 73 | 12 | 3 | 74.2 | 45 | 18 | 16 | 6 | 30 | 76 | 2 | 0 | 2 | 1.00 | 5.42 | 0.72 | 3.62 | 9.16 | 2.17 | 2.53 | 2006- 1- 28-BOS | premium | premium | premium | MLB | 2009-2023 | 2004-2025 | 2010 |
| 58 | Jonathan Papelbon | 29 | R | 5 | 7 | 3.90 | 65 | 0 | 0 | 0 | 65 | 53 | 37 | 67.0 | 57 | 34 | 29 | 7 | 28 | 76 | 4 | 0 | 2 | 1.27 | 7.66 | 0.94 | 3.76 | 10.21 | 4.57 | 2.71 | 2003- 4- 114-BOS | premium | premium | premium | MLB | 2005-2016 | 2001-2016 | 2010 |
| 48 | Scott Atchison | 34 | R | 2 | 3 | 4.50 | 43 | 1 | 0 | 0 | 42 | 8 | 0 | 60.0 | 58 | 37 | 30 | 9 | 19 | 41 | 4 | 0 | 1 | 1.28 | 8.70 | 1.35 | 2.85 | 6.15 | 5.55 | 2.16 | 1998- 49-1424-SEA | premium | premium | premium | MLB | 2004-2015 | 1995-2015 | 2010 |
| 68 | Robert Coello | 25 | R | 0 | 0 | 4.76 | 6 | 0 | 0 | 0 | 6 | 2 | 0 | 5.2 | 4 | 3 | 3 | 0 | 5 | 5 | 1 | 0 | 0 | 1.59 | 6.35 | 0.00 | 7.94 | 7.94 | 4.76 | 1.00 | 2004- 20- 588-CIN | premium | premium | premium | MLB | 2010-2013 | 2007-2015 | 2010 |
| 37 | Hideki Okajima | 34 | L | 4 | 4 | 4.50 | 56 | 0 | 0 | 0 | 56 | 12 | 0 | 46.0 | 59 | 24 | 23 | 6 | 20 | 33 | 2 | 0 | 0 | 1.72 | 11.54 | 1.17 | 3.91 | 6.46 | 4.70 | 1.65 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2013 | 1995-2015 | 2010 |
| 17 | Manny Delcarmen | 28 | R | 3 | 2 | 4.70 | 48 | 0 | 0 | 0 | 48 | 9 | 0 | 44.0 | 33 | 24 | 23 | 7 | 28 | 32 | 0 | 0 | 1 | 1.39 | 6.75 | 1.43 | 5.73 | 6.55 | 4.91 | 1.14 | 2000- 2- 62-BOS | premium | premium | premium | MLB | 2005-2010 | 2001-2018 | 2010 |
| 56 | Ramon Ramirez | 28 | R | 0 | 3 | 4.46 | 44 | 0 | 0 | 0 | 44 | 17 | 2 | 42.1 | 39 | 21 | 21 | 6 | 16 | 31 | 4 | 1 | 0 | 1.30 | 8.29 | 1.28 | 3.40 | 6.59 | 4.46 | 1.94 | 1996- UDFA -TEX | premium | premium | premium | MLB | 2006-2014 | 2002-2022 | 2010 |
| 53 | Rich Hill | 30 | L | 1 | 0 | 0.00 | 6 | 0 | 0 | 0 | 6 | 0 | 0 | 4.0 | 5 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 1.50 | 11.25 | 0.00 | 2.25 | 6.75 | 0.00 | 3.00 | 2002- 4- 112-CHN | premium | premium | premium | MLB | 2005-2025 | 2000-2025 | 2010 |
| 61 | Felix Doubront | 22 | L | 2 | 2 | 4.32 | 12 | 3 | 0 | 0 | 9 | 5 | 2 | 25.0 | 27 | 16 | 12 | 3 | 10 | 23 | 3 | 0 | 1 | 1.48 | 9.72 | 1.08 | 3.60 | 8.28 | 5.76 | 2.30 | 2004- UDFA -BOS | premium | premium | premium | MLB | 2010-2015 | 2006-2025 | 2010 |
| 40 | John Lackey | 31 | R | 14 | 11 | 4.40 | 33 | 33 | 0 | 0 | 0 | 0 | 0 | 215.0 | 233 | 114 | 105 | 18 | 72 | 156 | 3 | 0 | 9 | 1.42 | 9.75 | 0.75 | 3.01 | 6.53 | 4.77 | 2.17 | 1999- 2- 68-ANA | premium | premium | premium | MLB | 2002-2017 | 1998-2017 | 2010 |
| 31 | Jon Lester | 26 | L | 19 | 9 | 3.25 | 32 | 32 | 2 | 0 | 0 | 0 | 0 | 208.0 | 167 | 81 | 75 | 14 | 83 | 225 | 6 | 0 | 10 | 1.20 | 7.23 | 0.61 | 3.59 | 9.74 | 3.50 | 2.71 | 2002- 2- 57-BOS | premium | premium | premium | MLB | 2006-2021 | 2002-2021 | 2010 |
| 30 | Boof Bonser | 28 | R | 0 | 0 | 18.00 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 2.0 | 6 | 4 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 4.00 | 27.00 | 0.00 | 9.00 | 0.00 | 18.00 | 0.00 | 2000- 1- 21-SFN | premium | premium | premium | MLB | 2006-2010 | 2000-2014 | 2010 |
| 11 | Clay Buchholz | 25 | R | 17 | 7 | 2.33 | 28 | 28 | 1 | 1 | 0 | 0 | 0 | 173.2 | 142 | 55 | 45 | 9 | 67 | 120 | 7 | 1 | 5 | 1.20 | 7.36 | 0.47 | 3.47 | 6.22 | 2.85 | 1.79 | 2005- 1- 42-BOS | premium | premium | premium | MLB | 2007-2019 | 2004-2019 | 2010 |
| 18 | Daisuke Matsuzaka | 29 | R | 9 | 6 | 4.69 | 25 | 25 | 0 | 0 | 0 | 0 | 0 | 153.2 | 137 | 84 | 80 | 13 | 74 | 133 | 4 | 0 | 8 | 1.37 | 8.02 | 0.76 | 4.33 | 7.79 | 4.92 | 1.80 | 2006- UDFA -BOS | premium | premium | premium | MLB | 2007-2014 | 1999-2021 | 2010 |
| 64 | Michael Bowden | 23 | R | 0 | 1 | 4.70 | 14 | 0 | 0 | 0 | 14 | 7 | 0 | 15.1 | 20 | 8 | 8 | 2 | 4 | 13 | 2 | 0 | 0 | 1.57 | 11.74 | 1.17 | 2.35 | 7.63 | 4.70 | 3.25 | 2005- 1- 47-BOS | premium | premium | premium | MLB | 2008-2013 | 2005-2021 | 2010 |
| 49 | Tim Wakefield | 43 | R | 4 | 10 | 5.34 | 32 | 19 | 0 | 0 | 13 | 10 | 0 | 140.0 | 153 | 92 | 83 | 19 | 36 | 84 | 11 | 1 | 5 | 1.35 | 9.84 | 1.22 | 2.31 | 5.40 | 5.91 | 2.33 | 1988- 8- 200-PIT | premium | premium | premium | MLB | 1992-2011 | 1988-2011 | 2010 |
| 60 | Scott Schoeneweis | 36 | L | 1 | 0 | 7.90 | 15 | 0 | 0 | 0 | 15 | 6 | 0 | 13.2 | 19 | 12 | 12 | 2 | 10 | 13 | 1 | 0 | 0 | 2.12 | 12.51 | 1.32 | 6.59 | 8.56 | 7.90 | 1.30 | 1996- 3- 85-CAL | premium | premium | premium | MLB | 1999-2010 | 1993-2010 | 2010 |
| 62 | Dustin Richardson | 26 | L | 0 | 0 | 4.15 | 26 | 0 | 0 | 0 | 26 | 4 | 0 | 13.0 | 15 | 6 | 6 | 2 | 14 | 12 | 0 | 0 | 1 | 2.23 | 10.38 | 1.38 | 9.69 | 8.31 | 4.15 | 0.86 | 2006- 5- 163-BOS | premium | premium | premium | MLB | 2009-2010 | 2005-2019 | 2010 |
| 19 | Josh Beckett | 30 | R | 6 | 6 | 5.78 | 21 | 21 | 0 | 0 | 0 | 0 | 0 | 127.2 | 151 | 89 | 82 | 20 | 45 | 116 | 3 | 0 | 8 | 1.54 | 10.64 | 1.41 | 3.17 | 8.18 | 6.27 | 2.58 | 1999- 1- 2-MIA | premium | premium | premium | MLB | 2001-2014 | 2000-2014 | 2010 |
| 59 | Robert Manuel | 26 | R | 1 | 0 | 4.26 | 10 | 0 | 0 | 0 | 10 | 6 | 0 | 12.2 | 10 | 6 | 6 | 5 | 7 | 5 | 0 | 0 | 0 | 1.34 | 7.11 | 3.55 | 4.97 | 3.55 | 4.26 | 0.71 | 2005- UDFA -NYN | premium | premium | premium | MLB | 2009-2010 | 2005-2011 | 2010 |
| 43 | Matt Fox | 27 | R | 0 | 0 | 10.80 | 3 | 0 | 0 | 0 | 3 | 1 | 0 | 1.2 | 4 | 2 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 3.00 | 21.60 | 0.00 | 5.40 | 0.00 | 10.80 | 0.00 | 2004- 1- 35-MIN | premium | premium | premium | MLB | 2010-2010 | 2002-2013 | 2010 |
| 53 | Fernando Cabrera | 28 | R | 0 | 0 | 20.25 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.1 | 2 | 3 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 3.00 | 13.50 | 6.75 | 13.50 | 0.00 | 20.25 | 0.00 | 1999- 10- 317-CLE | premium | premium | premium | MLB | 2004-2010 | 2000-2013 | 2010 |
| 22 | Bill Hall | 30 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1998- 6- 176-MIL | premium | premium | premium | MLB | 2002-2012 | 1998-2014 | 2010 |
| 44 | Jonathan Van Every | 30 | L | 0 | 0 | 18.00 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1.0 | 2 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 2.00 | 18.00 | 9.00 | 0.00 | 9.00 | 18.00 | 0.00 | 2000- 29- 876-CLE | premium | premium | premium | MLB | 2008-2010 | 2001-2011 | 2010 |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| Totals: | 89 | 73 | 4.20 | 605 | 162 | 3 | 1 | 159 | 443 | 44 | 1456.2 | 1402 | 744 | 679 | 152 | 580 | 1207 | 58 | 3 | 53 | 1.36 | 8.66 | 0.94 | 3.58 | 7.46 | 4.60 | 2.08 | premium | premium | premium |