| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 10 | Michael Young | 33 | 3B | R | 104 | 157 | 656 | 99 | 186 | 36 | 3 | 21 | 91 | 4 | 2 | 50 | 115 | 1 | 0 | 11 | 4 | 21 | 291 | 718 | 60 | 126 | .284 | .330 | .444 | .774 | .239 | .160 | .311 | 6.96 | 16.02 | 2.30 | 31.24 | 1997- 5- 149-TOR | premium | premium | premium | MLB | 2000-2013 | 1995-2013 | 2010 |
| 27 | Vladimir Guerrero | 35 | DH | R | 113 | 152 | 593 | 83 | 178 | 27 | 1 | 29 | 115 | 4 | 5 | 35 | 60 | 9 | 0 | 6 | 5 | 19 | 294 | 643 | 57 | 121 | .300 | .345 | .496 | .841 | .253 | .196 | .292 | 5.44 | 9.33 | 1.71 | 20.45 | 1993- UDFA -MON | premium | premium | premium | MLB | 1996-2011 | 1994-2012 | 2010 |
| 1 | Elvis Andrus | 21 | SS | R | 92 | 148 | 588 | 88 | 156 | 15 | 3 | 0 | 35 | 32 | 15 | 64 | 96 | 5 | 17 | 0 | 0 | 6 | 177 | 674 | 18 | 138 | .265 | .342 | .301 | .643 | .173 | .036 | .317 | 9.50 | 14.24 | 1.50 | 0.00 | 2005- UDFA -ATL | premium | premium | premium | MLB | 2009-2023 | 2005-2023 | 2010 |
| 32 | Josh Hamilton | 29 | LF | L | 139 | 133 | 518 | 95 | 186 | 40 | 3 | 32 | 100 | 8 | 1 | 43 | 95 | 5 | 1 | 4 | 5 | 11 | 328 | 571 | 75 | 111 | .359 | .411 | .633 | 1.044 | .371 | .274 | .390 | 7.53 | 16.64 | 2.21 | 16.19 | 1999- 1- 1-TBA | premium | premium | premium | MLB | 2007-2015 | 1999-2016 | 2010 |
| 29 | Julio Borbon | 24 | CF | L | 90 | 137 | 438 | 60 | 121 | 11 | 4 | 3 | 42 | 15 | 7 | 19 | 59 | 2 | 8 | 1 | 0 | 5 | 149 | 468 | 18 | 103 | .276 | .309 | .340 | .649 | .126 | .064 | .313 | 4.06 | 12.61 | 3.11 | 146.00 | 2007- 1- 35-TEX | premium | premium | premium | MLB | 2009-2016 | 2005-2018 | 2010 |
| 7 | David Murphy | 28 | LF-RF | L | 111 | 138 | 419 | 54 | 122 | 26 | 2 | 12 | 65 | 14 | 2 | 45 | 71 | 0 | 0 | 3 | 2 | 6 | 188 | 467 | 40 | 82 | .291 | .358 | .449 | .807 | .294 | .158 | .324 | 9.64 | 15.20 | 1.58 | 34.92 | 2003- 1- 17-BOS | premium | premium | premium | MLB | 2006-2015 | 2001-2016 | 2010 |
| 17 | Nelson Cruz | 29 | RF | R | 127 | 108 | 399 | 60 | 127 | 31 | 3 | 22 | 78 | 17 | 4 | 38 | 81 | 1 | 1 | 6 | 5 | 12 | 230 | 445 | 56 | 71 | .318 | .374 | .576 | .950 | .386 | .258 | .348 | 8.54 | 18.20 | 2.13 | 18.14 | 1998- UDFA -NYN | premium | premium | premium | MLB | 2005-2023 | 2001-2023 | 2010 |
| 5 | Ian Kinsler | 28 | 2B | R | 111 | 103 | 391 | 73 | 112 | 20 | 1 | 9 | 45 | 15 | 5 | 56 | 57 | 7 | 2 | 4 | 2 | 11 | 161 | 460 | 30 | 82 | .286 | .382 | .412 | .794 | .294 | .126 | .313 | 12.17 | 12.39 | 1.02 | 43.44 | 2003- 17- 496-TEX | premium | premium | premium | MLB | 2006-2019 | 2002-2021 | 2010 |
| 20 | Matt Treanor | 34 | C | R | 83 | 82 | 237 | 22 | 50 | 6 | 1 | 5 | 27 | 1 | 2 | 22 | 43 | 5 | 4 | 4 | 0 | 4 | 73 | 272 | 12 | 38 | .211 | .287 | .308 | .595 | .186 | .097 | .233 | 8.09 | 15.81 | 1.95 | 47.40 | 1994- 4- 107-KCA | premium | premium | premium | MLB | 2004-2012 | 1994-2012 | 2010 |
| 12 | Justin Smoak | 23 | 1B | B | 94 | 70 | 235 | 29 | 49 | 10 | 0 | 8 | 34 | 1 | 0 | 38 | 57 | 0 | 0 | 2 | 4 | 6 | 83 | 275 | 18 | 31 | .209 | .316 | .353 | .669 | .311 | .144 | .238 | 13.82 | 20.73 | 1.50 | 29.38 | 2008- 1- 11-TEX | premium | premium | premium | MLB | 2010-2020 | 2006-2021 | 2010 |
| 11 | Bengie Molina | 35 | C | R | 86 | 57 | 175 | 10 | 42 | 6 | 1 | 2 | 19 | 0 | 0 | 10 | 15 | 1 | 5 | 4 | 0 | 7 | 56 | 195 | 9 | 33 | .240 | .279 | .320 | .599 | .137 | .080 | .247 | 5.13 | 7.69 | 1.50 | 87.50 | 1993- UDFA -CAL | premium | premium | premium | MLB | 1998-2010 | 1993-2010 | 2010 |
| 3 | Andres Blanco | 26 | 2B | B | 93* | 68 | 166 | 17 | 46 | 10 | 1 | 0 | 13 | 0 | 2 | 11 | 24 | 3 | 3 | 2 | 1 | 0 | 58 | 185 | 11 | 35 | .277 | .330 | .349 | .679 | .127 | .072 | .319 | 5.95 | 12.97 | 2.18 | 0.00 | 2000- UDFA -KCA | premium | premium | premium | MLB | 2004-2017 | 2002-2019 | 2010 |
| 18 | Mitch Moreland | 24 | 1B | L | 111* | 47 | 145 | 20 | 37 | 4 | 0 | 9 | 25 | 3 | 1 | 25 | 36 | 1 | 0 | 2 | 5 | 3 | 68 | 173 | 13 | 24 | .255 | .364 | .469 | .833 | .400 | .214 | .275 | 14.45 | 20.81 | 1.44 | 16.11 | 2007- 17- 530-TEX | premium | premium | premium | MLB | 2010-2021 | 2005-2021 | 2010 |
| 19 | Chris Davis | 24 | 1B | L | 80* | 45 | 120 | 7 | 23 | 9 | 0 | 1 | 4 | 3 | 0 | 15 | 40 | 0 | 0 | 1 | 3 | 3 | 35 | 136 | 10 | 13 | .192 | .279 | .292 | .571 | .250 | .100 | .275 | 11.03 | 29.41 | 2.67 | 120.00 | 2006- 5- 148-TEX | premium | premium | premium | MLB | 2008-2020 | 2006-2020 | 2010 |
| 8 | Jorge Cantu | 28 | 1B | R | 95 | 30 | 98 | 9 | 23 | 4 | 1 | 1 | 2 | 0 | 0 | 6 | 19 | 0 | 1 | 0 | 0 | 4 | 32 | 105 | 6 | 17 | .235 | .279 | .327 | .606 | .153 | .092 | .282 | 5.71 | 18.10 | 3.17 | 98.00 | 1998- UDFA -TBA | premium | premium | premium | MLB | 2004-2011 | 1999-2022 | 2010 |
| 14 | Joaquin Arias | 25 | 2B | R | 83* | 50 | 98 | 18 | 27 | 5 | 1 | 0 | 9 | 1 | 0 | 2 | 17 | 0 | 1 | 0 | 0 | 2 | 34 | 101 | 6 | 21 | .276 | .290 | .347 | .637 | .102 | .071 | .333 | 1.98 | 16.83 | 8.50 | 0.00 | 2001- UDFA -NYA | premium | premium | premium | MLB | 2006-2015 | 2002-2015 | 2010 |
| 2 | Taylor Teagarden | 26 | C | R | 28 | 71 | 10 | 11 | 1 | 0 | 4 | 6 | 0 | 0 | 8 | 34 | 2 | 4 | 0 | 0 | 0 | 24 | 85 | 5 | 6 | .155 | .259 | .338 | .597 | .296 | .183 | .212 | 9.41 | 40.00 | 4.25 | 17.75 | 2005- 3- 99-TEX | premium | premium | premium | MLB | 2008-2015 | 2003-2015 | 2010 | |
| 51 | Max Ramirez | 25 | C | R | 28 | 69 | 8 | 15 | 3 | 0 | 2 | 8 | 0 | 0 | 12 | 22 | 2 | 0 | 2 | 0 | 3 | 24 | 85 | 5 | 10 | .217 | .341 | .348 | .689 | .304 | .131 | .277 | 14.12 | 25.88 | 1.83 | 34.50 | 2002- UDFA -ATL | premium | premium | premium | MLB | 2008-2010 | 2004-2018 | 2010 | |
| 21 | Jeff Francoeur | 26 | RF | R | 92 | 15 | 53 | 9 | 18 | 2 | 0 | 2 | 11 | 0 | 1 | 1 | 5 | 1 | 0 | 1 | 0 | 2 | 26 | 56 | 4 | 14 | .340 | .357 | .491 | .848 | .151 | .151 | .340 | 1.79 | 8.93 | 5.00 | 26.50 | 2002- 1- 23-ATL | premium | premium | premium | MLB | 2005-2016 | 2002-2016 | 2010 |
| 15 | Cristian Guzman | 32 | 2B | B | 89 | 15 | 46 | 4 | 7 | 1 | 0 | 0 | 1 | 0 | 0 | 3 | 10 | 0 | 1 | 0 | 0 | 2 | 8 | 50 | 1 | 6 | .152 | .204 | .174 | .378 | .087 | .022 | .194 | 6.00 | 20.00 | 3.33 | 0.00 | 1994- UDFA -NYA | premium | premium | premium | MLB | 1999-2010 | 1996-2010 | 2010 |
| 25 | Ryan Garko | 29 | 1B-DH | R | 15 | 33 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 3 | 4 | 0 | 2 | 0 | 1 | 1 | 3 | 38 | 0 | 3 | .091 | .167 | .091 | .258 | .091 | .000 | .103 | 7.89 | 10.53 | 1.33 | 0.00 | 2003- 3- 78-CLE | premium | premium | premium | MLB | 2005-2010 | 2000-2012 | 2010 | |
| 23 | Craig Gentry | 26 | CF-LF | R | 20 | 33 | 4 | 7 | 0 | 0 | 0 | 3 | 1 | 0 | 1 | 11 | 0 | 0 | 1 | 0 | 1 | 7 | 35 | 0 | 7 | .212 | .229 | .212 | .441 | .061 | .000 | .304 | 2.86 | 31.43 | 11.00 | 0.00 | 2006- 10- 298-TEX | premium | premium | premium | MLB | 2009-2018 | 2005-2019 | 2010 | |
| 6 | Esteban German | 32 | 2B | R | 13 | 13 | 5 | 3 | 0 | 0 | 0 | 1 | 4 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 16 | 0 | 3 | .231 | .375 | .231 | .606 | .462 | .000 | .273 | 18.75 | 12.50 | 0.67 | 0.00 | 1996- UDFA -OAK | premium | premium | premium | MLB | 2002-2011 | 1998-2015 | 2010 | |
| 48 | Colby Lewis | 30 | P | R | 2 | 7 | 1 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 8 | 0 | 2 | .286 | .286 | .286 | .572 | .000 | .000 | .400 | 0.00 | 25.00 | 0.00 | 0.00 | 1999- 1- 38-TEX | premium | premium | premium | MLB | 2002-2016 | 1999-2016 | 2010 | |
| 12 | Alex Cora | 34 | 2B-3B | L | 77* | 4 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 0 | 2 | .286 | .286 | .286 | .572 | .000 | .000 | .286 | 0.00 | 0.00 | 0.00 | 0.00 | 1996- 3- 88-LAN | premium | premium | premium | MLB | 1998-2011 | 1994-2011 | 2010 |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 41 | Brandon Boggs | 27 | RF | B | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | .000 | .125 | .000 | .125 | .143 | .000 | .000 | 12.50 | 50.00 | 4.00 | 0.00 | 2004- 4- 111-TEX | premium | premium | premium | MLB | 2008-2011 | 2002-2015 | 2010 | |
| 39 | Scott Feldman | 27 | P | L | 2 | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 1 | 0 | .167 | .167 | .333 | .500 | .167 | .166 | .333 | 0.00 | 50.00 | 0.00 | 0.00 | 2003- 30- 886-TEX | premium | premium | premium | MLB | 2005-2017 | 2003-2017 | 2010 | |
| 21 | Jarrod Saltalamacchia | 25 | C | B | 2 | 5 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 1 | .200 | .200 | .200 | .400 | .000 | .000 | .250 | 0.00 | 20.00 | 0.00 | 0.00 | 2003- 1- 36-ATL | premium | premium | premium | MLB | 2007-2018 | 2003-2018 | 2010 | |
| 36 | C.J. Wilson | 29 | P | L | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 20.00 | 0.00 | 0.00 | 2001- 5- 141-TEX | premium | premium | premium | MLB | 2005-2015 | 2001-2016 | 2010 | |
| 35 | Tommy Hunter | 23 | P | R | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2007- 1- 54-TEX | premium | premium | premium | MLB | 2008-2023 | 2006-2023 | 2010 | |
| 40 | Rich Harden | 28 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2000- 17- 510-OAK | premium | premium | premium | MLB | 2003-2011 | 2001-2011 | 2010 | |
| 54 | Matt Harrison | 24 | P | L | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 2003- 3- 97-ATL | premium | premium | premium | MLB | 2008-2015 | 2003-2015 | 2010 | |
| 64 | Alexi Ogando | 26 | P | R | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1.000 | 1.000 | 1.000 | 2.000 | .000 | .000 | 1.000 | 0.00 | 0.00 | 0.00 | 0.00 | 2002- UDFA -OAK | premium | premium | premium | MLB | 2010-2018 | 2003-2018 | 2010 | |
| 57 | Dustin Nippert | 29 | P | R | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 0.00 | 0.00 | 0.00 | 2002- 15- 459-ARI | premium | premium | premium | MLB | 2005-2010 | 2002-2010 | 2010 | |
| Totals: | 1683 | 5635 | 787 | 1556 | 268 | 25 | 162 | 740 | 123 | 48 | 511 | 986 | 45 | 53 | 54 | 37 | 129 | 2360 | 6298 | 455 | 1101 | .276 | .338 | .419 | .757 | .247 | .143 | .307 | 8.11 | 15.66 | 1.93 | 34.78 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 40 | Rich Harden | 28 | R | 5 | 5 | 5.58 | 20 | 18 | 0 | 0 | 2 | 0 | 0 | 92.0 | 91 | 61 | 57 | 18 | 62 | 75 | 4 | 0 | 9 | 1.66 | 8.90 | 1.76 | 6.07 | 7.34 | 5.97 | 1.21 | 2000- 17- 510-OAK | premium | premium | premium | MLB | 2003-2011 | 2001-2011 | 2010 |
| 59 | Clay Rapada | 29 | L | 0 | 0 | 4.00 | 13 | 0 | 0 | 0 | 13 | 2 | 0 | 9.0 | 6 | 4 | 4 | 2 | 7 | 5 | 0 | 0 | 0 | 1.44 | 6.00 | 2.00 | 7.00 | 5.00 | 4.00 | 0.71 | 2002- UDFA -CHN | premium | premium | premium | MLB | 2007-2013 | 2002-2015 | 2010 |
| 54 | Matt Harrison | 24 | L | 3 | 2 | 4.71 | 37 | 6 | 0 | 0 | 31 | 9 | 2 | 78.1 | 80 | 45 | 41 | 10 | 39 | 46 | 4 | 0 | 2 | 1.52 | 9.19 | 1.15 | 4.48 | 5.29 | 5.17 | 1.18 | 2003- 3- 97-ATL | premium | premium | premium | MLB | 2008-2015 | 2003-2015 | 2010 |
| 68 | Omar Beltre | 28 | R | 0 | 1 | 9.00 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 7.0 | 9 | 7 | 7 | 3 | 7 | 9 | 0 | 0 | 2 | 2.29 | 11.57 | 3.86 | 9.00 | 11.57 | 9.00 | 1.29 | 2000- UDFA -TEX | premium | premium | premium | MLB | 2010-2010 | 2000-2011 | 2010 |
| 30 | Neftali Feliz | 22 | R | 4 | 3 | 2.73 | 70 | 0 | 0 | 0 | 70 | 59 | 40 | 69.1 | 43 | 21 | 21 | 5 | 18 | 71 | 5 | 0 | 5 | 0.88 | 5.58 | 0.65 | 2.34 | 9.22 | 2.73 | 3.94 | 2005- UDFA -ATL | premium | premium | premium | MLB | 2009-2021 | 2006-2025 | 2010 |
| 56 | Darren O'Day | 27 | R | 6 | 2 | 2.03 | 72 | 0 | 0 | 0 | 72 | 14 | 0 | 62.0 | 43 | 15 | 14 | 5 | 12 | 45 | 0 | 0 | 5 | 0.89 | 6.24 | 0.73 | 1.74 | 6.53 | 2.18 | 3.75 | 2006- UDFA -ANA | premium | premium | premium | MLB | 2008-2022 | 2003-2022 | 2010 |
| 28 | Darren Oliver | 39 | L | 1 | 2 | 2.48 | 64 | 0 | 0 | 0 | 64 | 7 | 1 | 61.2 | 53 | 20 | 17 | 4 | 15 | 65 | 0 | 0 | 2 | 1.10 | 7.74 | 0.58 | 2.19 | 9.49 | 2.92 | 4.33 | 1988- 3- 63-TEX | premium | premium | premium | MLB | 1993-2013 | 1988-2013 | 2010 |
| 45 | Derek Holland | 23 | L | 3 | 4 | 4.08 | 14 | 10 | 0 | 0 | 4 | 2 | 0 | 57.1 | 55 | 30 | 26 | 6 | 24 | 54 | 0 | 1 | 4 | 1.38 | 8.63 | 0.94 | 3.77 | 8.48 | 4.71 | 2.25 | 2006- 25- 748-TEX | premium | premium | premium | MLB | 2009-2021 | 2007-2023 | 2010 |
| 57 | Dustin Nippert | 29 | R | 4 | 5 | 4.29 | 38 | 2 | 0 | 0 | 36 | 7 | 0 | 56.2 | 61 | 28 | 27 | 7 | 34 | 47 | 3 | 0 | 5 | 1.68 | 9.69 | 1.11 | 5.40 | 7.46 | 4.45 | 1.38 | 2002- 15- 459-ARI | premium | premium | premium | MLB | 2005-2010 | 2002-2010 | 2010 |
| 50 | Frank Francisco | 30 | R | 6 | 4 | 3.76 | 56 | 0 | 0 | 0 | 56 | 20 | 2 | 52.2 | 49 | 23 | 22 | 5 | 18 | 60 | 2 | 1 | 1 | 1.27 | 8.37 | 0.85 | 3.08 | 10.25 | 3.93 | 3.33 | 1996- UDFA -BOS | premium | premium | premium | MLB | 2004-2014 | 1999-2014 | 2010 |
| 64 | Alexi Ogando | 26 | R | 4 | 1 | 1.30 | 44 | 0 | 0 | 0 | 44 | 12 | 0 | 41.2 | 31 | 6 | 6 | 2 | 16 | 39 | 3 | 0 | 1 | 1.13 | 6.70 | 0.43 | 3.46 | 8.42 | 1.30 | 2.44 | 2002- UDFA -OAK | premium | premium | premium | MLB | 2010-2018 | 2003-2018 | 2010 |
| 49 | Chris Ray | 28 | R | 2 | 0 | 3.41 | 35 | 0 | 0 | 0 | 35 | 6 | 1 | 31.2 | 24 | 12 | 12 | 4 | 16 | 16 | 1 | 0 | 0 | 1.26 | 6.82 | 1.14 | 4.55 | 4.55 | 3.41 | 1.00 | 2003- 3- 74-BAL | premium | premium | premium | MLB | 2005-2011 | 2001-2012 | 2010 |
| 49 | Mark Lowe | 27 | R | 0 | 0 | 12.00 | 3 | 0 | 0 | 0 | 3 | 1 | 0 | 3.0 | 7 | 4 | 4 | 1 | 1 | 5 | 0 | 0 | 0 | 2.67 | 21.00 | 3.00 | 3.00 | 15.00 | 12.00 | 5.00 | 2004- 5- 153-SEA | premium | premium | premium | MLB | 2006-2016 | 2002-2019 | 2010 |
| 52 | Doug Mathis | 27 | R | 1 | 1 | 6.04 | 13 | 0 | 0 | 0 | 13 | 7 | 0 | 22.1 | 30 | 15 | 15 | 7 | 11 | 10 | 0 | 0 | 0 | 1.84 | 12.09 | 2.82 | 4.43 | 4.03 | 6.04 | 0.91 | 2005- 13- 399-TEX | premium | premium | premium | MLB | 2008-2010 | 2005-2014 | 2010 |
| 36 | C.J. Wilson | 29 | L | 15 | 8 | 3.35 | 33 | 33 | 3 | 0 | 0 | 0 | 0 | 204.0 | 161 | 83 | 76 | 10 | 93 | 170 | 7 | 1 | 10 | 1.25 | 7.10 | 0.44 | 4.10 | 7.50 | 3.66 | 1.83 | 2001- 5- 141-TEX | premium | premium | premium | MLB | 2005-2015 | 2001-2016 | 2010 |
| 48 | Colby Lewis | 30 | R | 12 | 13 | 3.72 | 32 | 32 | 1 | 0 | 0 | 0 | 0 | 201.0 | 174 | 90 | 83 | 21 | 65 | 196 | 9 | 0 | 6 | 1.19 | 7.79 | 0.94 | 2.91 | 8.78 | 4.03 | 3.02 | 1999- 1- 38-TEX | premium | premium | premium | MLB | 2002-2016 | 1999-2016 | 2010 |
| 62 | Michael Kirkman | 23 | L | 0 | 0 | 1.65 | 14 | 0 | 0 | 0 | 14 | 2 | 0 | 16.1 | 9 | 3 | 3 | 0 | 10 | 16 | 0 | 0 | 0 | 1.16 | 4.96 | 0.00 | 5.51 | 8.82 | 1.65 | 1.60 | 2005- 5- 159-TEX | premium | premium | premium | MLB | 2010-2016 | 2005-2016 | 2010 |
| 39 | Scott Feldman | 27 | R | 7 | 11 | 5.48 | 29 | 22 | 0 | 0 | 7 | 2 | 0 | 141.1 | 181 | 98 | 86 | 18 | 45 | 75 | 11 | 0 | 5 | 1.60 | 11.53 | 1.15 | 2.87 | 4.78 | 6.24 | 1.67 | 2003- 30- 886-TEX | premium | premium | premium | MLB | 2005-2017 | 2003-2017 | 2010 |
| 35 | Tommy Hunter | 23 | R | 13 | 4 | 3.73 | 23 | 22 | 1 | 0 | 1 | 0 | 0 | 128.0 | 126 | 55 | 53 | 21 | 33 | 68 | 1 | 0 | 3 | 1.24 | 8.86 | 1.48 | 2.32 | 4.78 | 3.87 | 2.06 | 2007- 1- 54-TEX | premium | premium | premium | MLB | 2008-2023 | 2006-2023 | 2010 |
| 33 | Cliff Lee | 31 | L | 4 | 6 | 3.98 | 15 | 15 | 2 | 0 | 0 | 0 | 0 | 108.2 | 103 | 53 | 48 | 11 | 12 | 96 | 1 | 0 | 1 | 1.06 | 8.53 | 0.91 | 0.99 | 7.95 | 4.39 | 8.00 | 2000- 4- 105-MON | premium | premium | premium | MLB | 2002-2014 | 2000-2014 | 2010 |
| 46 | Pedro Strop | 25 | R | 0 | 0 | 10.12 | 15 | 0 | 0 | 0 | 15 | 5 | 0 | 10.2 | 17 | 12 | 12 | 2 | 11 | 11 | 5 | 1 | 1 | 2.62 | 14.34 | 1.69 | 9.28 | 9.28 | 10.12 | 1.00 | 2002- UDFA -COL | premium | premium | premium | MLB | 2009-2021 | 2003-2023 | 2010 |
| 58 | Guillermo Moscoso | 26 | R | 0 | 0 | 27.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0.2 | 2 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 1 | 6.00 | 27.00 | 0.00 | 27.00 | 27.00 | 27.00 | 1.00 | 2002- UDFA -DET | premium | premium | premium | MLB | 2009-2013 | 2005-2022 | 2010 |
| Totals: | 90 | 72 | 3.93 | 643 | 162 | 7 | 0 | 155 | 481 | 46 | 1455.1 | 1355 | 687 | 636 | 162 | 551 | 1181 | 56 | 4 | 63 | 1.31 | 8.38 | 1.00 | 3.41 | 7.30 | 4.25 | 2.14 | premium | premium | premium |