| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 7 | Craig Biggio | 40 | 2B | R | 95 | 145 | 548 | 79 | 135 | 33 | 0 | 21 | 62 | 3 | 2 | 40 | 84 | 9 | 5 | 5 | 1 | 15 | 231 | 607 | 54 | 81 | .246 | .306 | .422 | .728 | .250 | .176 | .254 | 6.59 | 13.84 | 2.10 | 26.10 | 1987- 1- 22-HOU | premium | premium | premium | MLB | 1988-2007 | 1985-2007 | 2006 |
| 17 | Lance Berkman | 30 | 1B | B | 129 | 152 | 536 | 95 | 169 | 29 | 0 | 45 | 136 | 3 | 2 | 98 | 106 | 4 | 0 | 8 | 22 | 11 | 333 | 646 | 74 | 95 | .315 | .420 | .621 | 1.041 | .491 | .306 | .316 | 15.17 | 16.41 | 1.08 | 11.91 | 1997- 1- 16-HOU | premium | premium | premium | MLB | 1999-2013 | 1995-2013 | 2006 |
| 1 | Willy Taveras | 24 | CF | R | 92 | 149 | 529 | 83 | 147 | 19 | 5 | 1 | 30 | 33 | 9 | 34 | 88 | 11 | 11 | 2 | 0 | 6 | 179 | 587 | 25 | 122 | .278 | .333 | .338 | .671 | .170 | .060 | .330 | 5.79 | 14.99 | 2.59 | 529.00 | 1999- UDFA -CLE | premium | premium | premium | MLB | 2004-2010 | 2000-2019 | 2006 |
| 28 | Adam Everett | 29 | SS | R | 83 | 150 | 514 | 52 | 123 | 28 | 6 | 6 | 59 | 9 | 6 | 34 | 71 | 4 | 10 | 4 | 5 | 5 | 181 | 566 | 40 | 83 | .239 | .290 | .352 | .642 | .185 | .113 | .265 | 6.01 | 12.54 | 2.09 | 85.67 | 1998- 1- 12-BOS | premium | premium | premium | MLB | 2001-2011 | 1996-2011 | 2006 |
| 11 | Brad Ausmus | 37 | C | R | 81 | 139 | 439 | 37 | 101 | 16 | 1 | 2 | 39 | 3 | 1 | 45 | 71 | 6 | 9 | 3 | 2 | 21 | 125 | 502 | 19 | 82 | .230 | .308 | .285 | .593 | .162 | .055 | .268 | 8.96 | 14.14 | 1.58 | 219.50 | 1987- 48-1152-NYA | premium | premium | premium | MLB | 1993-2010 | 1988-2010 | 2006 |
| 4 | Preston Wilson | 31 | LF | R | 96 | 102 | 390 | 40 | 105 | 22 | 2 | 9 | 55 | 6 | 2 | 22 | 94 | 2 | 0 | 3 | 2 | 18 | 158 | 417 | 33 | 72 | .269 | .309 | .405 | .714 | .203 | .136 | .331 | 5.28 | 22.54 | 4.27 | 43.33 | 1992- 1- 9-NYN | premium | premium | premium | MLB | 1998-2007 | 1993-2009 | 2006 |
| 14 | Morgan Ensberg | 30 | 3B | R | 111 | 127 | 387 | 67 | 91 | 17 | 1 | 23 | 58 | 1 | 4 | 101 | 96 | 4 | 0 | 3 | 7 | 3 | 179 | 495 | 41 | 50 | .235 | .396 | .463 | .859 | .481 | .228 | .251 | 20.40 | 19.39 | 0.95 | 16.83 | 1998- 9- 272-HOU | premium | premium | premium | MLB | 2000-2008 | 1995-2008 | 2006 |
| 26 | Mike Lamb | 30 | 1B-3B | L | 106 | 126 | 381 | 70 | 117 | 22 | 3 | 12 | 45 | 2 | 4 | 35 | 55 | 0 | 0 | 5 | 6 | 10 | 181 | 421 | 37 | 80 | .307 | .361 | .475 | .836 | .255 | .168 | .329 | 8.31 | 13.06 | 1.57 | 31.75 | 1997- 7- 227-TEX | premium | premium | premium | MLB | 2000-2010 | 1995-2011 | 2006 |
| 2 | Chris Burke | 26 | 2B-CF | R | 102 | 123 | 366 | 58 | 101 | 23 | 1 | 9 | 40 | 11 | 1 | 27 | 77 | 14 | 4 | 2 | 0 | 6 | 153 | 413 | 33 | 68 | .276 | .347 | .418 | .765 | .243 | .142 | .326 | 6.54 | 18.64 | 2.85 | 40.67 | 2001- 1- 10-HOU | premium | premium | premium | MLB | 2004-2009 | 1999-2010 | 2006 |
| 16 | Jason Lane | 29 | RF | R | 94 | 112 | 288 | 44 | 58 | 10 | 0 | 15 | 45 | 1 | 2 | 49 | 75 | 2 | 2 | 4 | 0 | 6 | 113 | 345 | 25 | 33 | .201 | .318 | .392 | .710 | .358 | .191 | .213 | 14.20 | 21.74 | 1.53 | 19.20 | 1999- 6- 203-HOU | premium | premium | premium | MLB | 2002-2014 | 1998-2015 | 2006 |
| 9 | Aubrey Huff | 29 | RF-3B | L | 104 | 68 | 224 | 31 | 56 | 10 | 1 | 13 | 38 | 0 | 0 | 26 | 39 | 7 | 0 | 4 | 3 | 7 | 107 | 261 | 24 | 32 | .250 | .341 | .478 | .819 | .344 | .228 | .244 | 9.96 | 14.94 | 1.50 | 17.23 | 1998- 5- 162-TBA | premium | premium | premium | MLB | 2000-2012 | 1997-2012 | 2006 |
| 30 | Luke Scott | 28 | LF | L | 132 | 65 | 214 | 31 | 72 | 19 | 6 | 10 | 37 | 2 | 1 | 30 | 43 | 4 | 0 | 1 | 4 | 2 | 133 | 249 | 35 | 37 | .336 | .426 | .621 | 1.047 | .430 | .285 | .383 | 12.05 | 17.27 | 1.43 | 21.40 | 2001- 9- 277-CLE | premium | premium | premium | MLB | 2005-2013 | 2000-2015 | 2006 |
| 58,13 | Eric Munson | 28 | C | L | 81* | 53 | 141 | 10 | 28 | 6 | 0 | 5 | 19 | 0 | 0 | 11 | 32 | 3 | 0 | 1 | 1 | 2 | 49 | 156 | 11 | 17 | .199 | .269 | .348 | .617 | .227 | .149 | .219 | 7.05 | 20.51 | 2.91 | 28.20 | 1999- 1- 3-DET | premium | premium | premium | MLB | 2000-2009 | 1997-2011 | 2006 |
| 19 | Orlando Palmeiro | 37 | LF-RF | L | 81* | 103 | 119 | 12 | 30 | 6 | 1 | 0 | 17 | 0 | 1 | 6 | 17 | 1 | 2 | 0 | 0 | 2 | 38 | 128 | 7 | 23 | .252 | .294 | .319 | .613 | .109 | .067 | .294 | 4.69 | 13.28 | 2.83 | 0.00 | 1991- 33- 870-CAL | premium | premium | premium | MLB | 1995-2007 | 1990-2007 | 2006 |
| 10 | Eric Bruntlett | 28 | 2B-SS | R | 93* | 73 | 119 | 11 | 33 | 8 | 0 | 0 | 10 | 3 | 1 | 13 | 21 | 1 | 2 | 1 | 1 | 2 | 41 | 136 | 8 | 25 | .277 | .351 | .345 | .696 | .193 | .068 | .333 | 9.56 | 15.44 | 1.62 | 0.00 | 2000- 9- 277-HOU | premium | premium | premium | MLB | 2003-2009 | 1997-2010 | 2006 |
| 44 | Roy Oswalt | 28 | P | R | 33 | 66 | 3 | 10 | 1 | 0 | 1 | 8 | 0 | 0 | 4 | 15 | 0 | 20 | 0 | 0 | 2 | 14 | 90 | 2 | 8 | .152 | .200 | .212 | .412 | .121 | .060 | .180 | 4.44 | 16.67 | 3.75 | 66.00 | 1996- 23- 684-HOU | premium | premium | premium | MLB | 2001-2013 | 1997-2013 | 2006 | |
| 21 | Andy Pettitte | 34 | P | L | 36 | 62 | 4 | 12 | 3 | 0 | 1 | 5 | 0 | 0 | 1 | 19 | 0 | 10 | 0 | 0 | 0 | 18 | 73 | 4 | 8 | .194 | .206 | .290 | .496 | .113 | .096 | .262 | 1.37 | 26.03 | 19.00 | 62.00 | 1990- 22- 594-NYA | premium | premium | premium | MLB | 1995-2013 | 1991-2013 | 2006 | |
| 51 | Wandy Rodriguez | 27 | P | B | 28 | 37 | 4 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 10 | 0 | 5 | 0 | 0 | 0 | 3 | 43 | 0 | 3 | .081 | .105 | .081 | .186 | .027 | .000 | .111 | 2.33 | 23.26 | 10.00 | 0.00 | 1999- UDFA -HOU | premium | premium | premium | MLB | 2005-2015 | 2001-2015 | 2006 | |
| 39 | Taylor Buchholz | 24 | P | R | 21 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11 | 0 | 4 | 0 | 0 | 0 | 1 | 35 | 0 | 1 | .033 | .065 | .033 | .098 | .033 | .000 | .053 | 2.86 | 31.43 | 11.00 | 0.00 | 2000- 6- 175-PHI | premium | premium | premium | MLB | 2006-2011 | 2000-2011 | 2006 | |
| 22 | Roger Clemens | 43 | P | R | 18 | 27 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 11 | 1 | 7 | 0 | 0 | 0 | 3 | 38 | 1 | 1 | .074 | .194 | .111 | .305 | .148 | .037 | .125 | 7.89 | 28.95 | 3.67 | 0.00 | 1983- 1- 19-BOS | premium | premium | premium | MLB | 1984-2007 | 1982-2012 | 2006 | |
| 46 | Humberto Quintero | 26 | C | R | 11 | 21 | 2 | 7 | 2 | 0 | 0 | 2 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 2 | 9 | 22 | 2 | 5 | .333 | .364 | .429 | .793 | .143 | .096 | .389 | 4.55 | 13.64 | 3.00 | 0.00 | 1997- UDFA -CHA | premium | premium | premium | MLB | 2003-2014 | 1999-2016 | 2006 | |
| 64 | Fernando Nieve | 23 | P | R | 38 | 16 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 8 | 0 | 5 | 0 | 0 | 0 | 2 | 23 | 0 | 2 | .125 | .222 | .125 | .347 | .125 | .000 | .250 | 8.70 | 34.78 | 4.00 | 0.00 | 1999- UDFA -HOU | premium | premium | premium | MLB | 2006-2010 | 2001-2018 | 2006 | |
| 53 | Jason Hirsh | 24 | P | R | 9 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 2 | 0 | 0 | 0 | 0 | 17 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 52.94 | 0.00 | 0.00 | 2003- 2- 59-HOU | premium | premium | premium | MLB | 2006-2008 | 2003-2013 | 2006 | |
| 41 | Brandon Backe | 28 | P | R | 9 | 14 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 1 | 2 | 15 | 0 | 2 | .143 | .200 | .143 | .343 | .071 | .000 | .250 | 6.67 | 40.00 | 6.00 | 0.00 | 1998- 18- 552-TBA | premium | premium | premium | MLB | 2002-2009 | 1998-2009 | 2006 | |
| 59 | J.R. House | 26 | C-1B | R | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 9 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 22.22 | 0.00 | 0.00 | 1999- 5- 152-PIT | premium | premium | premium | MLB | 2003-2008 | 1999-2011 | 2006 | |
| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 52 | Charlton Jimerson | 26 | RF | R | 17 | 6 | 2 | 2 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5 | 6 | 1 | 1 | .333 | .333 | .833 | 1.166 | .833 | .500 | .500 | 0.00 | 50.00 | 0.00 | 6.00 | 2001- 5- 146-HOU | premium | premium | premium | MLB | 2006-2008 | 1998-2010 | 2006 | |
| 23 | Joe McEwing | 33 | 2B | R | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 33.33 | 0.00 | 0.00 | 1992- 28- 783-SLN | premium | premium | premium | MLB | 1998-2006 | 1992-2007 | 2006 | |
| 43 | Chris Sampson | 28 | P | R | 12 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 28.57 | 0.00 | 0.00 | 1999- 8- 263-HOU | premium | premium | premium | MLB | 2006-2010 | 1999-2011 | 2006 | |
| 58 | Dave Borkowski | 29 | P | R | 37 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 20.00 | 0.00 | 0.00 | 1995- 11- 294-DET | premium | premium | premium | MLB | 1999-2008 | 1995-2009 | 2006 | |
| 37 | Matt Albers | 23 | P | L | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 75.00 | 0.00 | 0.00 | 2001- 23- 686-HOU | premium | premium | premium | MLB | 2006-2019 | 2002-2019 | 2006 | |
| 56 | Hector Gimenez | 23 | C | B | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 50.00 | 0.00 | 0.00 | 1999- UDFA -HOU | premium | premium | premium | MLB | 2006-2013 | 2002-2016 | 2006 | |
| 45 | Mike Gallo | 29 | P | L | 23 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | .000 | .000 | .000 | .000 | .000 | .000 | .000 | 0.00 | 100.00 | 0.00 | 0.00 | 1999- 5- 173-HOU | premium | premium | premium | MLB | 2003-2006 | 1997-2010 | 2006 | |
| Totals: | 1996 | 5521 | 735 | 1407 | 275 | 27 | 174 | 708 | 79 | 36 | 585 | 1076 | 73 | 100 | 46 | 54 | 122 | 2258 | 6325 | 476 | 931 | .255 | .332 | .409 | .741 | .268 | .154 | .286 | 9.25 | 17.01 | 1.84 | 31.73 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 64 | Fernando Nieve | 23 | R | 3 | 3 | 4.20 | 40 | 11 | 0 | 0 | 29 | 11 | 0 | 96.1 | 87 | 46 | 45 | 18 | 41 | 70 | 1 | 0 | 0 | 1.33 | 8.13 | 1.68 | 3.83 | 6.54 | 4.30 | 1.71 | 1999- UDFA -HOU | premium | premium | premium | MLB | 2006-2010 | 2001-2018 | 2006 |
| 50 | Chad Qualls | 27 | R | 7 | 3 | 3.76 | 81 | 0 | 0 | 0 | 81 | 13 | 0 | 88.2 | 76 | 38 | 37 | 10 | 28 | 56 | 0 | 0 | 0 | 1.17 | 7.71 | 1.02 | 2.84 | 5.68 | 3.86 | 2.00 | 2000- 2- 67-HOU | premium | premium | premium | MLB | 2004-2017 | 1999-2017 | 2006 |
| 54 | Brad Lidge | 29 | R | 1 | 5 | 5.28 | 78 | 0 | 0 | 0 | 78 | 52 | 32 | 75.0 | 69 | 47 | 44 | 10 | 36 | 104 | 11 | 0 | 6 | 1.40 | 8.28 | 1.20 | 4.32 | 12.48 | 5.64 | 2.89 | 1998- 1- 17-HOU | premium | premium | premium | MLB | 2002-2012 | 1996-2012 | 2006 |
| 35 | Dan Wheeler | 28 | R | 3 | 5 | 2.52 | 75 | 0 | 0 | 0 | 75 | 25 | 9 | 71.1 | 58 | 22 | 20 | 5 | 24 | 68 | 0 | 0 | 0 | 1.15 | 7.32 | 0.63 | 3.03 | 8.58 | 2.78 | 2.83 | 1996- 34-1024-TBA | premium | premium | premium | MLB | 1999-2012 | 1997-2013 | 2006 |
| 58 | Dave Borkowski | 29 | R | 3 | 2 | 4.69 | 40 | 0 | 0 | 0 | 40 | 12 | 0 | 71.0 | 70 | 38 | 37 | 8 | 23 | 52 | 2 | 0 | 0 | 1.31 | 8.87 | 1.01 | 2.92 | 6.59 | 4.82 | 2.26 | 1995- 11- 294-DET | premium | premium | premium | MLB | 1999-2008 | 1995-2009 | 2006 |
| 36 | Russ Springer | 37 | R | 1 | 1 | 3.47 | 72 | 0 | 0 | 0 | 72 | 17 | 0 | 59.2 | 46 | 23 | 23 | 10 | 16 | 46 | 2 | 0 | 0 | 1.04 | 6.94 | 1.51 | 2.41 | 6.94 | 3.47 | 2.88 | 1989- 7- 181-NYA | premium | premium | premium | MLB | 1992-2010 | 1987-2010 | 2006 |
| 47 | Trever Miller | 33 | L | 2 | 3 | 3.02 | 70 | 0 | 0 | 0 | 70 | 14 | 1 | 50.2 | 42 | 17 | 17 | 7 | 13 | 56 | 1 | 0 | 0 | 1.09 | 7.46 | 1.24 | 2.31 | 9.95 | 3.02 | 4.31 | 1991- 1- 41-DET | premium | premium | premium | MLB | 1996-2011 | 1991-2011 | 2006 |
| 38 | Ezequiel Astacio | 26 | R | 2 | 0 | 11.12 | 6 | 0 | 0 | 0 | 6 | 2 | 0 | 5.2 | 7 | 7 | 7 | 2 | 6 | 6 | 0 | 0 | 0 | 2.29 | 11.12 | 3.18 | 9.53 | 9.53 | 11.12 | 1.00 | 1998- UDFA -PHI | premium | premium | premium | MLB | 2005-2006 | 2001-2011 | 2006 |
| 53 | Jason Hirsh | 24 | R | 3 | 4 | 6.04 | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 44.2 | 48 | 32 | 30 | 11 | 22 | 29 | 4 | 0 | 3 | 1.57 | 9.67 | 2.22 | 4.43 | 5.84 | 6.45 | 1.32 | 2003- 2- 59-HOU | premium | premium | premium | MLB | 2006-2008 | 2003-2013 | 2006 |
| 41 | Brandon Backe | 28 | R | 3 | 2 | 3.77 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 43.0 | 43 | 18 | 18 | 4 | 18 | 19 | 2 | 0 | 3 | 1.42 | 9.00 | 0.84 | 3.77 | 3.98 | 3.77 | 1.06 | 1998- 18- 552-TBA | premium | premium | premium | MLB | 2002-2009 | 1998-2009 | 2006 |
| 43 | Chris Sampson | 28 | R | 2 | 1 | 2.12 | 12 | 3 | 0 | 0 | 9 | 0 | 0 | 34.0 | 25 | 10 | 8 | 3 | 5 | 15 | 0 | 0 | 0 | 0.88 | 6.62 | 0.79 | 1.32 | 3.97 | 2.65 | 3.00 | 1999- 8- 263-HOU | premium | premium | premium | MLB | 2006-2010 | 1999-2011 | 2006 |
| 44 | Roy Oswalt | 28 | R | 15 | 8 | 2.98 | 33 | 32 | 2 | 0 | 1 | 1 | 0 | 220.2 | 220 | 76 | 73 | 18 | 38 | 166 | 1 | 1 | 0 | 1.17 | 8.97 | 0.73 | 1.55 | 6.77 | 3.10 | 4.37 | 1996- 23- 684-HOU | premium | premium | premium | MLB | 2001-2013 | 1997-2013 | 2006 |
| 21 | Andy Pettitte | 34 | L | 14 | 13 | 4.20 | 36 | 35 | 2 | 1 | 1 | 1 | 0 | 214.1 | 238 | 114 | 100 | 27 | 70 | 178 | 2 | 1 | 0 | 1.44 | 9.99 | 1.13 | 2.94 | 7.47 | 4.79 | 2.54 | 1990- 22- 594-NYA | premium | premium | premium | MLB | 1995-2013 | 1991-2013 | 2006 |
| 45 | Mike Gallo | 29 | L | 1 | 2 | 6.06 | 23 | 0 | 0 | 0 | 23 | 7 | 0 | 16.1 | 28 | 11 | 11 | 3 | 7 | 7 | 4 | 0 | 2 | 2.14 | 15.43 | 1.65 | 3.86 | 3.86 | 6.06 | 1.00 | 1999- 5- 173-HOU | premium | premium | premium | MLB | 2003-2006 | 1997-2010 | 2006 |
| 37 | Matt Albers | 23 | R | 0 | 2 | 6.00 | 4 | 2 | 0 | 0 | 2 | 0 | 0 | 15.0 | 17 | 10 | 10 | 1 | 7 | 11 | 0 | 0 | 0 | 1.60 | 10.20 | 0.60 | 4.20 | 6.60 | 6.00 | 1.57 | 2001- 23- 686-HOU | premium | premium | premium | MLB | 2006-2019 | 2002-2019 | 2006 |
| 51 | Wandy Rodriguez | 27 | L | 9 | 10 | 5.64 | 30 | 24 | 0 | 0 | 6 | 1 | 0 | 135.2 | 154 | 96 | 85 | 17 | 63 | 98 | 6 | 0 | 0 | 1.60 | 10.22 | 1.13 | 4.18 | 6.50 | 6.37 | 1.56 | 1999- UDFA -HOU | premium | premium | premium | MLB | 2005-2015 | 2001-2015 | 2006 |
| 22 | Roger Clemens | 43 | R | 7 | 6 | 2.30 | 19 | 19 | 0 | 0 | 0 | 0 | 0 | 113.1 | 89 | 34 | 29 | 7 | 29 | 102 | 3 | 0 | 4 | 1.04 | 7.07 | 0.56 | 2.30 | 8.10 | 2.70 | 3.52 | 1983- 1- 19-BOS | premium | premium | premium | MLB | 1984-2007 | 1982-2012 | 2006 |
| 39 | Taylor Buchholz | 24 | R | 6 | 10 | 5.89 | 22 | 19 | 1 | 1 | 3 | 1 | 0 | 113.0 | 107 | 80 | 74 | 21 | 34 | 77 | 5 | 0 | 3 | 1.25 | 8.52 | 1.67 | 2.71 | 6.13 | 6.37 | 2.26 | 2000- 6- 175-PHI | premium | premium | premium | MLB | 2006-2011 | 2000-2011 | 2006 |
| 56 | Philip Barzilla | 27 | L | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 | 27.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2001- 4- 116-HOU | premium | premium | premium | MLB | 2006-2006 | 2000-2010 | 2006 |
| Totals: | 82 | 80 | 4.09 | 659 | 162 | 5 | 2 | 157 | 497 | 42 | 1468.2 | 1425 | 719 | 668 | 182 | 480 | 1160 | 44 | 2 | 21 | 1.30 | 8.73 | 1.12 | 2.94 | 7.11 | 4.41 | 2.42 | premium | premium | premium |