| # | player | age | pos | ba | tbc+ | g | ab | r | h | 2b | 3b | hr | rbi | sb | cs | bb | so | hbp | sh | sf | ibb | gdp | tb | pa | xbh | 1b | avg | obp | slg | ops | seca | iso | babip | bb% | so% | so/bb | ab/hr | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 12 | Pat Osborn | 24 | 3B | R | 104 | 129 | 478 | 66 | 137 | 18 | 1 | 10 | 63 | 14 | 4 | 37 | 66 | 7 | 2 | 1 | 0 | 18 | 187 | 525 | 29 | 108 | .287 | .346 | .391 | .737 | .203 | .104 | .315 | 7.05 | 12.57 | 1.78 | 47.80 | 2002- 2- 72-CLE | premium | premium | premium | AA | 2000-2013 | 2005 | |
| 9 | Eider Torres | 22 | 2B | B | 102 | 108 | 452 | 73 | 129 | 27 | 5 | 6 | 57 | 33 | 9 | 16 | 66 | 11 | 19 | 5 | 0 | 5 | 184 | 503 | 38 | 91 | .285 | .322 | .407 | .729 | .210 | .122 | .319 | 3.18 | 13.12 | 4.13 | 75.33 | 2000- UDFA -CLE | premium | premium | premium | MLB | 2008-2008 | 2002-2010 | 2005 |
| 13 | Ivan Ochoa | 22 | SS | R | 93 | 126 | 422 | 46 | 112 | 13 | 6 | 2 | 30 | 16 | 12 | 30 | 81 | 12 | 8 | 3 | 0 | 7 | 143 | 475 | 21 | 91 | .265 | .330 | .339 | .669 | .154 | .074 | .322 | 6.32 | 17.05 | 2.70 | 211.00 | 2000- UDFA -CLE | premium | premium | premium | MLB | 2008-2008 | 2001-2011 | 2005 |
| 17 | Jonathan Van Every | 25 | OF | L | 117 | 118 | 389 | 71 | 95 | 14 | 2 | 27 | 64 | 16 | 6 | 66 | 155 | 7 | 3 | 1 | 5 | 3 | 194 | 466 | 43 | 52 | .244 | .363 | .499 | .862 | .450 | .255 | .327 | 14.16 | 33.26 | 2.35 | 14.41 | 2000- 29- 876-CLE | premium | premium | premium | MLB | 2008-2010 | 2001-2011 | 2005 |
| 24 | Franklin Gutierrez | 22 | OF | R | 103 | 95 | 383 | 70 | 100 | 25 | 2 | 11 | 42 | 14 | 4 | 30 | 77 | 7 | 1 | 5 | 1 | 7 | 162 | 426 | 38 | 62 | .261 | .322 | .423 | .745 | .266 | .162 | .297 | 7.04 | 18.08 | 2.57 | 34.82 | 2000- UDFA -LAN | premium | premium | premium | MLB | 2005-2017 | 2001-2017 | 2005 |
| 7 | Shaun Larkin | 25 | 1B | L | 109 | 90 | 331 | 48 | 85 | 24 | 4 | 13 | 55 | 0 | 2 | 38 | 48 | 2 | 3 | 3 | 0 | 8 | 156 | 377 | 41 | 44 | .257 | .334 | .471 | .805 | .323 | .214 | .264 | 10.08 | 12.73 | 1.26 | 25.46 | 2002- 9- 274-CLE | premium | premium | premium | AAA | 2000-2007 | 2005 | |
| 23 | Javi Herrera | 24 | C | R | 89 | 98 | 328 | 45 | 74 | 20 | 0 | 6 | 36 | 3 | 3 | 18 | 78 | 14 | 7 | 0 | 0 | 6 | 112 | 367 | 26 | 48 | .226 | .294 | .341 | .635 | .171 | .115 | .279 | 4.90 | 21.25 | 4.33 | 54.67 | 2003- 2- 48-CLE | premium | premium | premium | AAA | 2001-2008 | 2005 | |
| 4 | Ben Francisco | 23 | OF | R | 114 | 83 | 323 | 45 | 99 | 19 | 7 | 7 | 46 | 15 | 4 | 24 | 59 | 2 | 2 | 1 | 1 | 4 | 153 | 352 | 33 | 66 | .307 | .357 | .474 | .831 | .276 | .167 | .357 | 6.82 | 16.76 | 2.46 | 46.14 | 2002- 5- 154-CLE | premium | premium | premium | MLB | 2007-2013 | 2001-2015 | 2005 |
| 20 | Brad Snyder | 23 | OF | L | 118 | 75 | 304 | 56 | 85 | 21 | 5 | 16 | 54 | 5 | 3 | 25 | 94 | 6 | 1 | 1 | 4 | 3 | 164 | 337 | 42 | 43 | .280 | .345 | .539 | .884 | .349 | .259 | .354 | 7.42 | 27.89 | 3.76 | 19.00 | 2003- 1- 18-CLE | premium | premium | premium | MLB | 2010-2014 | 2001-2017 | 2005 |
| 16 | Jose Morban | 25 | 2B-OF | B | 99 | 65 | 254 | 35 | 63 | 11 | 2 | 9 | 33 | 10 | 8 | 24 | 79 | 1 | 5 | 2 | 0 | 3 | 105 | 286 | 22 | 41 | .248 | .313 | .413 | .726 | .268 | .165 | .321 | 8.39 | 27.62 | 3.29 | 28.22 | 1996- UDFA -TEX | premium | premium | premium | MLB | 2003-2003 | 1999-2009 | 2005 |
| 22 | Ryan Mulhern | 24 | 1B | R | 131 | 67 | 244 | 40 | 76 | 18 | 3 | 15 | 46 | 4 | 2 | 28 | 64 | 3 | 0 | 2 | 1 | 8 | 145 | 277 | 36 | 40 | .311 | .386 | .594 | .980 | .406 | .283 | .365 | 10.11 | 23.10 | 2.29 | 16.27 | 2003- 11- 318-CLE | premium | premium | premium | AAA | 2001-2013 | 2005 | |
| 22 | Jason Cooper | 24 | OF | L | 114 | 57 | 205 | 41 | 52 | 9 | 2 | 11 | 42 | 3 | 2 | 30 | 67 | 6 | 0 | 4 | 1 | 5 | 98 | 245 | 22 | 30 | .254 | .359 | .478 | .837 | .376 | .224 | .313 | 12.24 | 27.35 | 2.23 | 18.64 | 2002- 3- 82-CLE | premium | premium | premium | AAA | 2000-2011 | 2005 | |
| 6 | Scott Youngbauer | 26 | 1B | B | 106 | 41 | 153 | 13 | 33 | 4 | 1 | 5 | 19 | 3 | 1 | 11 | 40 | 2 | 4 | 1 | 0 | 0 | 54 | 171 | 10 | 23 | .216 | .275 | .353 | .628 | .222 | .137 | .257 | 6.43 | 23.39 | 3.64 | 30.60 | 2000- 10- 295-PHI | premium | premium | premium | AAA | 1998-2007 | 2005 | |
| 10 | Michael Aubrey | 23 | 1B | L | 107* | 28 | 106 | 17 | 30 | 5 | 1 | 4 | 20 | 1 | 0 | 7 | 18 | 3 | 0 | 3 | 2 | 3 | 49 | 119 | 10 | 20 | .283 | .336 | .462 | .798 | .255 | .179 | .299 | 5.88 | 15.13 | 2.57 | 26.50 | 2003- 1- 11-CLE | premium | premium | premium | MLB | 2008-2009 | 2001-2011 | 2005 |
| 15 | Armando Camacaro | 26 | C | R | 96* | 34 | 105 | 12 | 27 | 3 | 0 | 3 | 13 | 3 | 2 | 6 | 25 | 4 | 2 | 1 | 0 | 3 | 39 | 118 | 6 | 21 | .257 | .319 | .371 | .690 | .181 | .114 | .308 | 5.08 | 21.19 | 4.17 | 35.00 | premium | premium | premium | AAA | 2001-2009 | 2005 | ||
| 6 | Anthony Lunetta | 24 | 2B-SS | R | 79* | 34 | 103 | 18 | 23 | 3 | 0 | 1 | 10 | 1 | 1 | 6 | 25 | 3 | 0 | 1 | 1 | 1 | 29 | 113 | 4 | 19 | .223 | .283 | .282 | .565 | .117 | .059 | .282 | 5.31 | 22.12 | 4.17 | 103.00 | 2003- 9- 258-CLE | premium | premium | premium | AA | 2000-2005 | 2005 | |
| 28 | Nathan Panther | 23 | OF | L | 103* | 22 | 80 | 13 | 22 | 3 | 1 | 1 | 6 | 1 | 1 | 10 | 15 | 1 | 0 | 0 | 0 | 2 | 30 | 91 | 5 | 17 | .275 | .363 | .375 | .738 | .225 | .100 | .328 | 10.99 | 16.48 | 1.50 | 80.00 | 2002- 15- 454-CLE | premium | premium | premium | AAA | 2002-2008 | 2005 | |
| 8 | J.J. Sherrill | 24 | OF | B | 21 | 60 | 8 | 15 | 3 | 2 | 1 | 5 | 0 | 2 | 6 | 16 | 1 | 1 | 2 | 1 | 0 | 25 | 70 | 6 | 9 | .250 | .319 | .417 | .736 | .233 | .167 | .311 | 8.57 | 22.86 | 2.67 | 60.00 | 1998- 23- 693-CLE | premium | premium | premium | AA | 1999-2013 | 2005 | ||
| 32 | Javier Cardona | 29 | C | R | 15 | 52 | 7 | 15 | 3 | 0 | 3 | 13 | 0 | 0 | 5 | 9 | 0 | 1 | 1 | 0 | 2 | 27 | 59 | 6 | 9 | .288 | .345 | .519 | .864 | .327 | .231 | .293 | 8.47 | 15.25 | 1.80 | 17.33 | 1994- 23- 641-DET | premium | premium | premium | MLB | 2000-2002 | 1994-2005 | 2005 | |
| - | Warren Morris | 31 | 2B | L | 5 | 22 | 1 | 2 | 1 | 0 | 0 | 2 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 3 | 23 | 1 | 1 | .091 | .130 | .136 | .266 | .136 | .045 | .111 | 4.35 | 17.39 | 4.00 | 0.00 | 1996- 5- 143-TEX | premium | premium | premium | MLB | 1999-2003 | 1994-2005 | 2005 | |
| - | Clayton McCullough | 25 | C | L | 4 | 11 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 12 | 0 | 1 | .091 | .167 | .091 | .258 | .182 | .000 | .167 | 8.33 | 41.67 | 5.00 | 0.00 | 2002- 22- 664-CLE | premium | premium | premium | AAA | 1999-2005 | 2005 | ||
| 24 | Trevor Crowe | 21 | OF | B | 3 | 10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 10 | 0 | 1 | .100 | .100 | .100 | .200 | .000 | .000 | .143 | 0.00 | 30.00 | 0.00 | 0.00 | 2005- 1- 14-CLE | premium | premium | premium | MLB | 2009-2013 | 2003-2014 | 2005 | |
| - | Travis Hafner | 28 | DH | L | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | .000 | .182 | .000 | .182 | .111 | .000 | .000 | 9.09 | 0.00 | 0.00 | 0.00 | 1996- 31- 923-TEX | premium | premium | premium | MLB | 2002-2013 | 1997-2018 | 2005 | |
| Totals: | 1321 | 4824 | 726 | 1276 | 244 | 44 | 151 | 657 | 144 | 66 | 420 | 1094 | 93 | 59 | 37 | 17 | 89 | 2061 | 5433 | 439 | 837 | .265 | .333 | .427 | .760 | .266 | .163 | .311 | 7.73 | 20.14 | 2.60 | 31.95 | premium | premium | premium |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| 37 | Roberto Hernandez | 24 | R | 6 | 5 | 4.07 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 90.2 | 100 | 46 | 41 | 7 | 20 | 57 | 2 | 0 | 8 | 1.32 | 9.93 | 0.69 | 1.99 | 5.66 | 4.57 | 2.85 | 2000- UDFA -CLE | premium | premium | premium | MLB | 2006-2016 | 2002-2016 | 2005 |
| - | Adam Hanson | 23 | R | 1 | 0 | 8.00 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 9.0 | 7 | 9 | 8 | 1 | 8 | 2 | 4 | 0 | 3 | 1.67 | 7.00 | 1.00 | 8.00 | 2.00 | 9.00 | 0.25 | 2003- 42-1247-CLE | premium | premium | premium | AAA | 2001-2007 | 2005 | |
| - | CC Sabathia | 24 | L | 0 | 1 | 1.00 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 9.0 | 4 | 3 | 1 | 0 | 2 | 9 | 1 | 0 | 1 | 0.67 | 4.00 | 0.00 | 2.00 | 9.00 | 3.00 | 4.50 | 1998- 1- 20-CLE | premium | premium | premium | MLB | 2001-2019 | 1998-2019 | 2005 |
| 55 | Jeremy Sowers | 22 | L | 5 | 1 | 2.08 | 13 | 13 | 0 | 0 | 0 | 0 | 0 | 82.1 | 74 | 25 | 19 | 8 | 9 | 70 | 2 | 0 | 3 | 1.01 | 8.09 | 0.87 | 0.98 | 7.65 | 2.73 | 7.78 | 2004- 1- 6-CLE | premium | premium | premium | MLB | 2006-2009 | 2002-2013 | 2005 |
| 39 | Rafael Perez | 23 | L | 4 | 3 | 1.75 | 15 | 8 | 0 | 0 | 7 | 3 | 1 | 66.2 | 53 | 22 | 13 | 5 | 12 | 46 | 3 | 0 | 2 | 0.97 | 7.15 | 0.67 | 1.62 | 6.21 | 2.97 | 3.83 | 2002- UDFA -CLE | premium | premium | premium | MLB | 2006-2012 | 2003-2017 | 2005 |
| 33 | Victor Kleine | 25 | L | 1 | 6 | 4.40 | 27 | 5 | 0 | 0 | 22 | 16 | 0 | 61.1 | 63 | 33 | 30 | 6 | 24 | 38 | 4 | 0 | 6 | 1.42 | 9.24 | 0.88 | 3.52 | 5.58 | 4.84 | 1.58 | 2000- 7- 216-CLE | premium | premium | premium | AAA | 2000-2007 | 2005 | |
| 28 | J.D. Martin | 22 | R | 3 | 1 | 2.38 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 56.2 | 42 | 17 | 15 | 3 | 8 | 63 | 1 | 0 | 3 | 0.88 | 6.67 | 0.48 | 1.27 | 10.01 | 2.70 | 7.88 | 2001- 1- 35-CLE | premium | premium | premium | MLB | 2009-2010 | 2001-2019 | 2005 |
| 27 | Chris Cooper | 26 | L | 4 | 1 | 2.08 | 43 | 0 | 0 | 0 | 43 | 28 | 8 | 56.1 | 50 | 19 | 13 | 3 | 18 | 60 | 2 | 0 | 1 | 1.21 | 7.99 | 0.48 | 2.88 | 9.59 | 3.04 | 3.33 | 2001- 35-1057-CLE | premium | premium | premium | AAA | 2000-2009 | 2005 | |
| 40 | Travis Foley | 22 | R | 6 | 2 | 3.86 | 36 | 0 | 0 | 0 | 36 | 9 | 1 | 53.2 | 53 | 30 | 23 | 5 | 26 | 40 | 7 | 1 | 0 | 1.47 | 8.89 | 0.84 | 4.36 | 6.71 | 5.03 | 1.54 | 2001- 4- 127-CLE | premium | premium | premium | AAA | 2001-2007 | 2005 | |
| - | Derrick Van Dusen | 24 | L | 1 | 0 | 1.69 | 4 | 0 | 0 | 0 | 4 | 2 | 0 | 5.1 | 6 | 1 | 1 | 1 | 2 | 4 | 0 | 0 | 0 | 1.50 | 10.13 | 1.69 | 3.38 | 6.75 | 1.69 | 2.00 | 2000- 5- 146-SEA | premium | premium | premium | AA | 2000-2007 | 2005 | |
| 29 | Jake Brooks | 27 | R | 0 | 0 | 5.06 | 6 | 0 | 0 | 0 | 6 | 2 | 0 | 5.1 | 4 | 3 | 3 | 0 | 1 | 2 | 1 | 1 | 2 | 0.94 | 6.75 | 0.00 | 1.69 | 3.38 | 5.06 | 2.00 | 1997- 23- 687-ANA | premium | premium | premium | AAA | 1998-2007 | 2005 | |
| - | Aaron Laffey | 20 | L | 1 | 0 | 3.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5.0 | 8 | 2 | 2 | 0 | 2 | 6 | 1 | 0 | 0 | 2.00 | 14.40 | 0.00 | 3.60 | 10.80 | 3.60 | 3.00 | 2003- 16- 468-CLE | premium | premium | premium | MLB | 2007-2015 | 2003-2018 | 2005 |
| - | Justin Pekarek | 24 | L | 1 | 0 | 0.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5.0 | 6 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 1.60 | 10.80 | 0.00 | 3.60 | 3.60 | 0.00 | 1.00 | 2004- 8- 227-CLE | premium | premium | premium | AA | 2001-2005 | 2005 | |
| 37 | Bear Bay | 21 | R | 3 | 3 | 4.76 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 45.1 | 45 | 24 | 24 | 5 | 13 | 40 | 2 | 0 | 2 | 1.28 | 8.93 | 0.99 | 2.58 | 7.94 | 4.76 | 3.08 | 2002- 25- 753-CHN | premium | premium | premium | AAA | 2003-2012 | 2005 | |
| 30 | Steve Green | 27 | R | 2 | 2 | 3.45 | 26 | 0 | 0 | 0 | 26 | 7 | 1 | 44.1 | 36 | 22 | 17 | 4 | 23 | 45 | 6 | 0 | 4 | 1.33 | 7.31 | 0.81 | 4.67 | 9.14 | 4.47 | 1.96 | 1997- 10- 297-ANA | premium | premium | premium | MLB | 2001-2001 | 1998-2011 | 2005 |
| 50 | Mariano Gomez | 22 | L | 4 | 3 | 6.30 | 18 | 4 | 1 | 0 | 14 | 3 | 0 | 40.0 | 45 | 35 | 28 | 4 | 20 | 27 | 6 | 2 | 4 | 1.63 | 10.13 | 0.90 | 4.50 | 6.08 | 7.88 | 1.35 | premium | premium | premium | AAA | 2000-2012 | 2005 | ||
| 46 | Mike Hernandez | 24 | L | 0 | 0 | 6.23 | 4 | 0 | 0 | 0 | 4 | 2 | 0 | 4.1 | 4 | 3 | 3 | 1 | 1 | 3 | 1 | 0 | 0 | 1.15 | 8.31 | 2.08 | 2.08 | 6.23 | 6.23 | 3.00 | 2002- 6- 184-CLE | premium | premium | premium | AA | 2000-2006 | 2005 | |
| 44 | Edward Mujica | 21 | R | 2 | 1 | 2.88 | 27 | 0 | 0 | 0 | 27 | 18 | 10 | 34.1 | 36 | 11 | 11 | 2 | 5 | 33 | 3 | 1 | 0 | 1.19 | 9.44 | 0.52 | 1.31 | 8.65 | 2.88 | 6.60 | 2001- UDFA -CLE | premium | premium | premium | MLB | 2006-2017 | 2003-2018 | 2005 |
| 45 | Billy Traber | 25 | L | 3 | 2 | 2.65 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 34.0 | 25 | 11 | 10 | 2 | 5 | 27 | 0 | 0 | 1 | 0.88 | 6.62 | 0.53 | 1.32 | 7.15 | 2.91 | 5.40 | 2000- 1- 16-NYN | premium | premium | premium | MLB | 2003-2009 | 1998-2010 | 2005 |
| - | Ryan Knippschild | 22 | L | 0 | 0 | 0.00 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 3.0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 1.00 | 3.00 | 0.00 | 6.00 | 3.00 | 0.00 | 0.50 | 2004- 35-1037-CLE | premium | premium | premium | AA | 2003-2011 | 2005 | |
| - | Dan Eisentrager | 24 | R | 0 | 0 | 6.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3.0 | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 1.67 | 12.00 | 3.00 | 3.00 | 3.00 | 9.00 | 1.00 | 2002- 30- 904-CLE | premium | premium | premium | AA | 2002-2006 | 2005 | |
| 38 | Travis Thompson | 27 | R | 4 | 0 | 1.80 | 15 | 0 | 0 | 0 | 15 | 5 | 0 | 25.0 | 15 | 7 | 5 | 1 | 8 | 16 | 1 | 2 | 1 | 0.92 | 5.40 | 0.36 | 2.88 | 5.76 | 2.52 | 2.00 | premium | premium | premium | AAA | 1996-2006 | 2005 | ||
| 48 | Juan Lara | 24 | L | 1 | 2 | 4.56 | 18 | 0 | 0 | 0 | 18 | 8 | 5 | 23.2 | 27 | 15 | 12 | 1 | 14 | 16 | 3 | 1 | 1 | 1.73 | 10.27 | 0.38 | 5.32 | 6.08 | 5.70 | 1.14 | 1999- UDFA -CLE | premium | premium | premium | MLB | 2006-2007 | 2002-2009 | 2005 |
| 45 | Tom Mastny | 24 | R | 1 | 1 | 2.18 | 5 | 3 | 0 | 0 | 2 | 1 | 0 | 20.2 | 18 | 7 | 5 | 0 | 5 | 18 | 1 | 0 | 2 | 1.11 | 7.84 | 0.00 | 2.18 | 7.84 | 3.05 | 3.60 | 2003- 11- 320-TOR | premium | premium | premium | MLB | 2006-2008 | 2000-2010 | 2005 |
| - | Scott Roehl | 23 | R | 0 | 1 | 7.71 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 2.1 | 4 | 2 | 2 | 2 | 1 | 3 | 0 | 1 | 0 | 2.14 | 15.43 | 7.71 | 3.86 | 11.57 | 7.71 | 3.00 | 2003- 10- 288-CLE | premium | premium | premium | AAA | 2001-2010 | 2005 | |
| # | player | age | th | w | l | era | g | gs | cg | sho | gr | gf | sv | ip | h | r | er | hr | bb | so | wp | bk | hb | whip | h9 | hr9 | bb9 | so9 | ra9 | so/bb | draft info | status | cur-org | cur-lev | hilvl | mlb years | stat years | year |
| - | Paul Shuey | 34 | R | 0 | 0 | 4.50 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 2.0 | 2 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 2.00 | 9.00 | 0.00 | 9.00 | 9.00 | 4.50 | 1.00 | 1992- 1- 2-CLE | premium | premium | premium | MLB | 1994-2007 | 1990-2007 | 2005 |
| 39 | Todd Pennington | 25 | R | 2 | 1 | 4.19 | 19 | 0 | 0 | 0 | 19 | 18 | 9 | 19.1 | 18 | 10 | 9 | 2 | 15 | 21 | 1 | 0 | 3 | 1.71 | 8.38 | 0.93 | 6.98 | 9.78 | 4.66 | 1.40 | 2001- 46-1376-CLE | premium | premium | premium | AA | 1999-2007 | 2005 | |
| 26 | Jake Dittler | 22 | R | 10 | 9 | 3.64 | 28 | 27 | 0 | 0 | 1 | 1 | 0 | 173.0 | 187 | 94 | 70 | 12 | 61 | 107 | 10 | 2 | 8 | 1.43 | 9.73 | 0.62 | 3.17 | 5.57 | 4.89 | 1.75 | 2001- 2- 51-CLE | premium | premium | premium | AAA | 2001-2011 | 2005 | |
| - | Joselo Diaz | 25 | R | 0 | 0 | 0.00 | 8 | 0 | 0 | 0 | 8 | 2 | 1 | 15.2 | 5 | 0 | 0 | 0 | 3 | 19 | 1 | 0 | 0 | 0.51 | 2.87 | 0.00 | 1.72 | 10.91 | 0.00 | 6.33 | 2006- UDFA -LAN | premium | premium | premium | MLB | 2006-2008 | 1997-2011 | 2005 |
| 29 | Dan Denham | 22 | R | 9 | 7 | 3.15 | 21 | 21 | 1 | 0 | 0 | 0 | 0 | 140.0 | 115 | 55 | 49 | 6 | 30 | 108 | 6 | 0 | 13 | 1.04 | 7.39 | 0.39 | 1.93 | 6.94 | 3.54 | 3.60 | 2001- 1- 17-CLE | premium | premium | premium | AAA | 2001-2009 | 2005 | |
| - | Jason Stanford | 28 | L | 2 | 0 | 2.45 | 8 | 0 | 0 | 0 | 8 | 3 | 0 | 14.2 | 15 | 5 | 4 | 1 | 4 | 13 | 0 | 0 | 4 | 1.30 | 9.20 | 0.61 | 2.45 | 7.98 | 3.07 | 3.25 | 1999- UDFA -CLE | premium | premium | premium | MLB | 2003-2007 | 1998-2008 | 2005 |
| 47 | Kyle Evans | 26 | R | 1 | 1 | 5.73 | 7 | 0 | 0 | 0 | 7 | 2 | 0 | 11.0 | 13 | 7 | 7 | 2 | 6 | 7 | 1 | 0 | 0 | 1.73 | 10.64 | 1.64 | 4.91 | 5.73 | 5.73 | 1.17 | 2000- 6- 186-CLE | premium | premium | premium | AAA | 1999-2005 | 2005 | |
| 25 | Brian Slocum | 24 | R | 7 | 5 | 4.40 | 21 | 18 | 1 | 0 | 3 | 2 | 0 | 102.1 | 98 | 52 | 50 | 9 | 36 | 95 | 2 | 0 | 6 | 1.31 | 8.62 | 0.79 | 3.17 | 8.36 | 4.57 | 2.64 | 2002- 2- 63-CLE | premium | premium | premium | MLB | 2006-2008 | 2000-2011 | 2005 |
| - | Arthur Rhodes | 35 | L | 0 | 0 | 0.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1988- 2- 34-BAL | premium | premium | premium | MLB | 1991-2011 | 1988-2011 | 2005 |
| - | Matt Miller | 33 | R | 0 | 0 | 0.00 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1997- UDFA -TEX | premium | premium | premium | MLB | 2003-2007 | 1996-2008 | 2005 |
| Totals: | 84 | 58 | 3.40 | 420 | 142 | 3 | 0 | 139 | 278 | 36 | 1266.1 | 1183 | 574 | 478 | 94 | 389 | 1001 | 72 | 11 | 79 | 1.24 | 8.41 | 0.67 | 2.76 | 7.11 | 4.08 | 2.57 | premium | premium | premium |