| Central | W | L | Pct | GB |
| Detroit | 88 | 74 | .543 | -- |
| Chi White Sox | 85 | 77 | .525 | 3.0 |
| KC Royals | 72 | 90 | .444 | 16.0 |
| Cleveland | 68 | 94 | .420 | 20.0 |
| Minnesota | 66 | 96 | .407 | 22.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-06 | John Danks | L | 27 | L 2-3 | @ TEX | 1 | 151 | L | 6.0 | 6 | 3 | 3 | 1 | 0 | 6 | 77 | 25 | 52 | 68% | 0-1 | 4.50 | 1.00 |
| 2012-04-07 | Jake Peavy | R | 31 | W 4-3 | @ TEX | 1 | 251 | - | 6.0 | 8 | 3 | 3 | 0 | 1 | 5 | 96 | 28 | 68 | 71% | 0-0 | 4.50 | 1.50 |
| 2012-04-08 | Gavin Floyd | R | 29 | L 0-5 | @ TEX | 1 | 153 | L | 5.2 | 5 | 5 | 4 | 3 | 2 | 3 | 85 | 36 | 49 | 58% | 0-1 | 6.00 | 1.17 |
| 2012-04-09 | Chris Sale | L | 23 | W 4-2 | @ CLE | 1 | 1 | W | 6.2 | 3 | 1 | 1 | 0 | 2 | 5 | 102 | 41 | 61 | 60% | 1-0 | 1.29 | 0.71 |
| 2012-04-11 | John Danks | L | 27 | W 10-6 | @ CLE | 2 | 152 | W | 5.2 | 7 | 4 | 4 | 1 | 5 | 3 | 111 | 48 | 63 | 57% | 1-1 | 5.25 | 1.50 |
| 2012-04-13 | Jake Peavy | R | 31 | L 5-2 | vs DET | 2 | 252 | W | 6.2 | 2 | 2 | 2 | 1 | 1 | 8 | 91 | 35 | 56 | 62% | 1-0 | 3.46 | 0.92 |
| 2012-04-14 | Gavin Floyd | R | 29 | L 5-1 | vs DET | 2 | 154 | W | 6.0 | 3 | 0 | 0 | 0 | 3 | 6 | 98 | 41 | 57 | 58% | 1-1 | 3.00 | 1.08 |
| 2012-04-15 | Chris Sale | L | 23 | W 2-5 | vs DET | 2 | 2 | L | 5.0 | 5 | 3 | 3 | 1 | 2 | 5 | 102 | 34 | 68 | 67% | 1-1 | 3.00 | 1.00 |
| 2012-04-16 | Philip Humber | R | 29 | W 4-10 | vs BAL | 1 | 29 | - | 5.1 | 6 | 1 | 1 | 0 | 3 | 7 | 114 | 46 | 68 | 60% | 0-0 | 1.80 | 1.80 |
| 2012-04-17 | John Danks | L | 27 | W 2-3 | vs BAL | 3 | 153 | L | 7.0 | 5 | 3 | 3 | 2 | 2 | 5 | 100 | 36 | 64 | 64% | 1-2 | 4.74 | 1.32 |
| 2012-04-18 | Jake Peavy | R | 31 | L 8-1 | vs BAL | 3 | 253 | W | 7.0 | 4 | 1 | 1 | 0 | 0 | 8 | 107 | 36 | 71 | 66% | 2-0 | 2.70 | 0.80 |
| 2012-04-19 | Gavin Floyd | R | 29 | W 3-5 | vs BAL | 3 | 155 | L | 6.0 | 6 | 5 | 5 | 1 | 3 | 7 | 116 | 44 | 72 | 62% | 1-2 | 4.50 | 1.22 |
| 2012-04-20 | Chris Sale | L | 23 | W 7-3 | @ SEA | 3 | 3 | W | 6.1 | 7 | 3 | 3 | 1 | 3 | 11 | 109 | 41 | 68 | 62% | 2-1 | 3.50 | 1.22 |
| 2012-04-21 | Philip Humber | R | 29 | W 4-0 | @ SEA | 2 | 30 | W | 9.0 | 0 | 0 | 0 | 0 | 0 | 9 | 96 | 29 | 67 | 70% | 1-0 | 0.64 | 0.64 |
| 2012-04-22 | John Danks | L | 27 | W 7-4 | @ SEA | 4 | 154 | W | 6.0 | 7 | 4 | 4 | 0 | 4 | 6 | 97 | 39 | 58 | 60% | 2-2 | 5.04 | 1.44 |
| 2012-04-23 | Jake Peavy | R | 31 | W 4-0 | @ OAK | 4 | 254 | W | 9.0 | 3 | 0 | 0 | 0 | 2 | 5 | 105 | 36 | 69 | 66% | 3-0 | 1.86 | 0.72 |
| 2012-04-24 | Gavin Floyd | R | 29 | L 0-2 | @ OAK | 4 | 156 | L | 7.1 | 2 | 1 | 1 | 0 | 2 | 6 | 118 | 48 | 70 | 59% | 1-3 | 3.60 | 1.04 |
| 2012-04-25 | Chris Sale | L | 23 | L 4-5 | @ OAK | 4 | 4 | - | 8.0 | 6 | 2 | 2 | 0 | 0 | 5 | 103 | 31 | 72 | 70% | 2-1 | 3.12 | 1.08 |
| 2012-04-26 | Philip Humber | R | 29 | W 3-10 | vs BOS | 3 | 31 | L | 5.0 | 8 | 9 | 9 | 3 | 3 | 5 | 114 | 41 | 73 | 64% | 1-1 | 4.74 | 1.05 |
| 2012-04-27 | John Danks | L | 27 | W 3-10 | vs BOS | 5 | 155 | L | 5.2 | 6 | 7 | 7 | 1 | 4 | 4 | 93 | 34 | 59 | 63% | 2-3 | 6.30 | 1.53 |
| 2012-04-28 | Jake Peavy | R | 31 | W 0-1 | vs BOS | 5 | 255 | L | 9.0 | 4 | 1 | 1 | 0 | 1 | 7 | 115 | 38 | 77 | 67% | 3-1 | 1.66 | 0.68 |
| 2012-04-29 | Gavin Floyd | R | 29 | L 4-1 | vs BOS | 5 | 157 | W | 6.2 | 3 | 1 | 1 | 0 | 1 | 9 | 110 | 41 | 69 | 63% | 2-3 | 3.09 | 0.94 |
| 2012-05-01 | Chris Sale | L | 23 | L 7-2 | vs CLE | 5 | 5 | W | 6.0 | 3 | 1 | 1 | 0 | 1 | 3 | 87 | 26 | 61 | 70% | 3-1 | 2.81 | 1.00 |
| 2012-05-02 | Philip Humber | R | 29 | W 3-6 | vs CLE | 4 | 32 | - | 6.0 | 4 | 3 | 3 | 1 | 6 | 6 | 106 | 41 | 65 | 61% | 1-1 | 4.68 | 1.20 |
| 2012-05-03 | John Danks | L | 27 | W 5-7 | vs CLE | 6 | 156 | L | 7.0 | 9 | 7 | 6 | 2 | 1 | 1 | 96 | 35 | 61 | 64% | 2-4 | 6.57 | 1.51 |
| 2012-05-04 | Jake Peavy | R | 31 | L 4-5 | @ DET | 6 | 256 | - | 7.2 | 7 | 3 | 3 | 1 | 1 | 6 | 118 | 41 | 77 | 65% | 3-1 | 2.00 | 0.76 |
| 2012-05-05 | Gavin Floyd | R | 29 | W 3-2 | @ DET | 6 | 158 | - | 7.0 | 7 | 2 | 2 | 0 | 0 | 6 | 108 | 41 | 67 | 62% | 2-3 | 3.00 | 0.95 |
| 2012-05-06 | Dylan Axelrod | R | 27 | L 1-3 | @ DET | 1 | 4 | L | 4.1 | 6 | 2 | 2 | 2 | 2 | 4 | 98 | 35 | 63 | 64% | 0-1 | 3.38 | 1.50 |
| 2012-05-07 | Philip Humber | R | 29 | L 6-8 | @ CLE | 5 | 33 | L | 2.1 | 9 | 8 | 8 | 1 | 2 | 1 | 69 | 28 | 41 | 59% | 1-2 | 6.75 | 1.46 |
| 2012-05-07 | Eric Stults | L | 32 | L 2-3 | @ CLE | 1 | 25 | - | 6.0 | 4 | 2 | 2 | 0 | 4 | 4 | 108 | 42 | 66 | 61% | 0-0 | 3.00 | 1.33 |
| 2012-05-08 | John Danks | L | 27 | W 5-3 | @ CLE | 7 | 157 | - | 7.0 | 5 | 2 | 2 | 0 | 3 | 1 | 104 | 41 | 63 | 61% | 2-4 | 5.93 | 1.45 |
| 2012-05-09 | Jake Peavy | R | 31 | W 8-1 | @ CLE | 7 | 257 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 5 | 104 | 34 | 70 | 67% | 4-1 | 1.90 | 0.81 |
| 2012-05-11 | Gavin Floyd | R | 29 | L 5-0 | vs KCA | 7 | 159 | W | 7.2 | 5 | 0 | 0 | 0 | 2 | 5 | 116 | 45 | 71 | 61% | 3-3 | 2.54 | 0.96 |
| 2012-05-12 | Chris Sale | L | 23 | W 0-5 | vs KCA | 6 | 6 | L | 5.0 | 7 | 3 | 3 | 0 | 2 | 3 | 102 | 37 | 65 | 64% | 3-2 | 3.08 | 1.13 |
| 2012-05-13 | Philip Humber | R | 29 | W 1-9 | vs KCA | 6 | 34 | - | 6.2 | 4 | 1 | 1 | 0 | 3 | 7 | 100 | 34 | 66 | 66% | 1-2 | 5.82 | 1.41 |
| 2012-05-14 | John Danks | L | 27 | L 7-5 | vs DET | 8 | 158 | - | 3.0 | 9 | 5 | 5 | 0 | 3 | 0 | 80 | 38 | 42 | 53% | 2-4 | 6.51 | 1.62 |
| 2012-05-15 | Jake Peavy | R | 31 | W 8-10 | vs DET | 8 | 258 | - | 5.1 | 9 | 6 | 6 | 2 | 2 | 4 | 103 | 43 | 60 | 58% | 4-1 | 2.64 | 0.91 |
| 2012-05-16 | Gavin Floyd | R | 29 | L 2-7 | @ ANA | 8 | 160 | L | 6.0 | 10 | 7 | 7 | 2 | 1 | 4 | 95 | 29 | 66 | 69% | 3-4 | 3.46 | 1.06 |
| 2012-05-17 | Chris Sale | L | 23 | W 6-1 | @ ANA | 7 | 7 | W | 5.1 | 5 | 1 | 1 | 1 | 1 | 7 | 102 | 35 | 67 | 66% | 4-2 | 2.93 | 1.14 |
| 2012-05-18 | Philip Humber | R | 29 | W 3-2 | @ CHN | 7 | 35 | - | 6.1 | 5 | 2 | 2 | 0 | 2 | 3 | 67 | 22 | 45 | 67% | 1-2 | 5.27 | 1.34 |
| 2012-05-19 | John Danks | L | 27 | W 7-4 | @ CHN | 9 | 159 | W | 6.1 | 3 | 0 | 0 | 0 | 1 | 4 | 83 | 29 | 54 | 65% | 3-4 | 5.67 | 1.48 |
| 2012-05-20 | Jake Peavy | R | 31 | W 6-0 | @ CHN | 9 | 259 | W | 6.1 | 3 | 0 | 0 | 0 | 2 | 7 | 99 | 30 | 69 | 70% | 5-1 | 2.39 | 0.91 |
| 2012-05-22 | Gavin Floyd | R | 29 | W 2-9 | vs MIN | 9 | 161 | L | 3.2 | 8 | 9 | 9 | 1 | 3 | 4 | 88 | 39 | 49 | 56% | 3-5 | 4.66 | 1.18 |
| 2012-05-23 | Chris Sale | L | 23 | L 6-0 | vs MIN | 8 | 8 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 6 | 97 | 33 | 64 | 66% | 5-2 | 2.52 | 1.06 |
| 2012-05-24 | Philip Humber | R | 29 | L 11-8 | vs MIN | 8 | 36 | - | 4.1 | 6 | 5 | 5 | 1 | 3 | 4 | 85 | 39 | 46 | 54% | 1-2 | 5.80 | 1.42 |
| 2012-05-25 | Jose Quintana | L | 23 | L 9-3 | vs CLE | 1 | 1 | W | 6.0 | 4 | 2 | 2 | 0 | 3 | 4 | 107 | 40 | 67 | 63% | 1-0 | 1.50 | 0.83 |
| 2012-05-26 | Jake Peavy | R | 31 | L 14-7 | vs CLE | 10 | 260 | W | 6.1 | 6 | 7 | 7 | 2 | 1 | 9 | 112 | 39 | 73 | 65% | 6-1 | 3.09 | 0.93 |
| 2012-05-27 | Gavin Floyd | R | 29 | L 12-6 | vs CLE | 10 | 162 | W | 5.0 | 10 | 5 | 5 | 1 | 0 | 4 | 89 | 30 | 59 | 66% | 4-5 | 5.02 | 1.25 |
| 2012-05-28 | Chris Sale | L | 23 | W 2-1 | @ TBA | 9 | 9 | W | 7.1 | 3 | 1 | 1 | 0 | 2 | 15 | 114 | 36 | 78 | 68% | 6-2 | 2.33 | 1.00 |
| 2012-05-29 | Philip Humber | R | 29 | W 7-2 | @ TBA | 9 | 37 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 5 | 112 | 41 | 71 | 63% | 2-2 | 5.37 | 1.35 |
| 2012-05-30 | Jose Quintana | L | 23 | W 4-3 | @ TBA | 2 | 2 | - | 3.2 | 1 | 1 | 1 | 1 | 0 | 2 | 50 | 19 | 31 | 62% | 1-0 | 1.80 | 0.73 |
| 2012-06-01 | Jake Peavy | R | 31 | L 7-4 | vs SEA | 11 | 261 | - | 6.1 | 3 | 2 | 2 | 1 | 3 | 4 | 99 | 36 | 63 | 64% | 6-1 | 3.04 | 0.92 |
| 2012-06-02 | Gavin Floyd | R | 29 | W 8-10 | vs SEA | 11 | 163 | - | 5.0 | 9 | 5 | 5 | 4 | 0 | 4 | 86 | 30 | 56 | 65% | 4-5 | 5.32 | 1.29 |
| 2012-06-03 | Chris Sale | L | 23 | L 4-2 | vs SEA | 10 | 10 | W | 9.0 | 5 | 2 | 2 | 1 | 2 | 8 | 118 | 38 | 80 | 68% | 7-2 | 2.28 | 0.97 |
| 2012-06-05 | Philip Humber | R | 29 | W 5-9 | vs TOR | 10 | 38 | L | 5.0 | 7 | 5 | 5 | 2 | 4 | 3 | 99 | 41 | 58 | 59% | 2-3 | 5.68 | 1.42 |
| 2012-06-06 | Jose Quintana | L | 23 | W 0-4 | vs TOR | 3 | 3 | L | 6.0 | 9 | 2 | 2 | 1 | 1 | 1 | 87 | 32 | 55 | 63% | 1-1 | 2.05 | 0.95 |
| 2012-06-07 | Jake Peavy | R | 31 | L 4-3 | vs TOR | 12 | 262 | - | 6.0 | 5 | 3 | 2 | 0 | 5 | 4 | 115 | 44 | 71 | 62% | 6-1 | 3.04 | 0.98 |
| 2012-06-08 | Gavin Floyd | R | 29 | W 3-8 | vs HOU | 12 | 164 | L | 6.0 | 4 | 4 | 4 | 2 | 2 | 9 | 84 | 30 | 54 | 64% | 4-6 | 5.38 | 1.26 |
| 2012-06-09 | Chris Sale | L | 23 | L 10-1 | vs HOU | 11 | 11 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 7 | 101 | 31 | 70 | 69% | 8-2 | 2.04 | 0.92 |
| 2012-06-10 | Philip Humber | R | 29 | W 9-11 | vs HOU | 11 | 39 | L | 5.1 | 6 | 6 | 5 | 3 | 2 | 9 | 86 | 27 | 59 | 69% | 2-4 | 5.95 | 1.44 |
| 2012-06-12 | Jose Quintana | L | 23 | W 6-1 | @ SLN | 4 | 4 | W | 5.1 | 10 | 1 | 1 | 0 | 0 | 4 | 76 | 20 | 56 | 74% | 2-1 | 2.00 | 1.15 |
| 2012-06-13 | Jake Peavy | R | 31 | L 0-1 | @ SLN | 13 | 263 | L | 7.0 | 4 | 1 | 1 | 1 | 2 | 6 | 89 | 31 | 58 | 65% | 6-2 | 2.90 | 0.97 |
| 2012-06-14 | Gavin Floyd | R | 29 | L 3-5 | @ SLN | 13 | 165 | L | 4.2 | 8 | 5 | 5 | 1 | 4 | 5 | 84 | 33 | 51 | 61% | 4-7 | 5.61 | 1.34 |
| 2012-06-15 | Chris Sale | L | 23 | L 6-7 | @ LAN | 12 | 12 | - | 5.2 | 7 | 5 | 5 | 0 | 4 | 6 | 112 | 40 | 72 | 64% | 8-2 | 2.48 | 1.00 |
| 2012-06-16 | Philip Humber | R | 29 | W 5-4 | @ LAN | 12 | 40 | W | 5.0 | 9 | 4 | 4 | 0 | 2 | 4 | 98 | 41 | 57 | 58% | 3-4 | 6.04 | 1.49 |
| 2012-06-17 | Jose Quintana | L | 23 | L 1-2 | @ LAN | 5 | 5 | - | 8.0 | 5 | 0 | 0 | 0 | 0 | 6 | 76 | 23 | 53 | 70% | 2-1 | 1.54 | 1.03 |
| 2012-06-18 | Zach Stewart | R | 26 | W 3-12 | vs CHN | 1 | 12 | L | 5.2 | 9 | 6 | 6 | 4 | 0 | 1 | 89 | 29 | 60 | 67% | 1-2 | 6.00 | 1.50 |
| 2012-06-19 | Jake Peavy | R | 31 | W 1-2 | vs CHN | 14 | 264 | L | 9.0 | 5 | 2 | 1 | 0 | 1 | 5 | 122 | 41 | 81 | 66% | 6-3 | 2.73 | 0.94 |
| 2012-06-20 | Gavin Floyd | R | 29 | L 7-0 | vs CHN | 14 | 166 | W | 6.1 | 4 | 0 | 0 | 0 | 1 | 4 | 108 | 36 | 72 | 67% | 5-7 | 5.20 | 1.30 |
| 2012-06-22 | Chris Sale | L | 23 | W 0-1 | vs MIL | 13 | 13 | - | 8.0 | 4 | 0 | 0 | 0 | 1 | 7 | 105 | 37 | 68 | 65% | 8-2 | 2.25 | 0.97 |
| 2012-06-23 | Dylan Axelrod | R | 27 | L 8-6 | vs MIL | 2 | 5 | - | 5.1 | 6 | 5 | 5 | 0 | 0 | 3 | 103 | 40 | 63 | 61% | 0-1 | 5.54 | 1.38 |
| 2012-06-24 | Jose Quintana | L | 23 | L 1-0 | vs MIL | 6 | 6 | - | 8.0 | 6 | 0 | 0 | 0 | 0 | 4 | 100 | 30 | 70 | 70% | 2-1 | 1.26 | 0.98 |
| 2012-06-25 | Jake Peavy | R | 31 | L 1-4 | @ MIN | 15 | 265 | L | 6.0 | 10 | 3 | 3 | 0 | 1 | 7 | 112 | 36 | 76 | 68% | 6-4 | 2.83 | 0.99 |
| 2012-06-26 | Gavin Floyd | R | 29 | W 3-2 | @ MIN | 15 | 167 | W | 7.0 | 5 | 0 | 0 | 0 | 0 | 9 | 96 | 34 | 62 | 65% | 6-7 | 4.80 | 1.26 |
| 2012-06-27 | Chris Sale | L | 23 | W 12-5 | @ MIN | 14 | 14 | W | 7.0 | 6 | 2 | 2 | 1 | 1 | 5 | 94 | 30 | 64 | 68% | 9-2 | 2.27 | 0.97 |
| 2012-06-28 | Dylan Axelrod | R | 27 | W 4-3 | @ NYA | 3 | 6 | - | 7.0 | 6 | 2 | 2 | 0 | 3 | 4 | 116 | 48 | 68 | 59% | 0-1 | 4.50 | 1.35 |
| 2012-06-29 | Jose Quintana | L | 23 | W 14-7 | @ NYA | 7 | 7 | W | 6.0 | 8 | 6 | 6 | 1 | 3 | 5 | 104 | 46 | 58 | 56% | 3-1 | 2.20 | 1.08 |
| 2012-06-30 | Jake Peavy | R | 31 | L 0-4 | @ NYA | 16 | 266 | L | 8.0 | 8 | 4 | 4 | 3 | 0 | 11 | 107 | 31 | 76 | 71% | 6-5 | 2.95 | 0.99 |
| 2012-07-01 | Gavin Floyd | R | 29 | L 2-4 | @ NYA | 16 | 168 | L | 5.1 | 8 | 4 | 4 | 2 | 5 | 3 | 128 | 56 | 72 | 56% | 6-8 | 4.93 | 1.33 |
| 2012-07-03 | Chris Sale | L | 23 | L 19-2 | vs TEX | 15 | 15 | W | 7.1 | 5 | 1 | 1 | 0 | 1 | 4 | 94 | 31 | 63 | 67% | 10-2 | 2.18 | 0.95 |
| 2012-07-04 | Dylan Axelrod | R | 27 | L 5-4 | vs TEX | 4 | 7 | - | 5.2 | 7 | 4 | 4 | 1 | 2 | 2 | 103 | 35 | 68 | 66% | 0-1 | 4.85 | 1.38 |
| 2012-07-05 | Jose Quintana | L | 23 | L 2-1 | vs TEX | 8 | 8 | W | 8.0 | 2 | 1 | 1 | 0 | 1 | 8 | 112 | 40 | 72 | 64% | 4-1 | 2.05 | 0.98 |
| 2012-07-06 | Jake Peavy | R | 31 | L 4-2 | vs TOR | 17 | 267 | W | 7.1 | 5 | 1 | 1 | 1 | 2 | 7 | 113 | 45 | 68 | 60% | 7-5 | 2.85 | 0.99 |
| 2012-07-07 | Gavin Floyd | R | 29 | L 2-0 | vs TOR | 17 | 169 | W | 7.2 | 4 | 0 | 0 | 0 | 2 | 3 | 100 | 39 | 61 | 61% | 7-8 | 4.54 | 1.28 |
| 2012-07-08 | Dylan Axelrod | R | 27 | W 9-11 | vs TOR | 5 | 8 | L | 3.0 | 6 | 7 | 7 | 3 | 2 | 4 | 70 | 29 | 41 | 59% | 0-2 | 6.52 | 1.52 |
| 2012-07-13 | Jose Quintana | L | 23 | W 9-8 | @ KCA | 9 | 9 | - | 5.0 | 8 | 5 | 5 | 2 | 3 | 4 | 115 | 42 | 73 | 63% | 4-1 | 2.61 | 1.08 |
| 2012-07-14 | Jake Peavy | R | 31 | L 3-6 | @ KCA | 18 | 268 | L | 7.0 | 12 | 6 | 6 | 2 | 1 | 5 | 123 | 37 | 86 | 70% | 7-6 | 3.12 | 1.04 |
| 2012-07-15 | Chris Sale | L | 23 | W 2-1 | @ KCA | 16 | 16 | W | 8.0 | 10 | 1 | 1 | 0 | 0 | 4 | 116 | 40 | 76 | 66% | 11-2 | 2.11 | 0.97 |
| 2012-07-16 | Dylan Axelrod | R | 27 | L 1-5 | @ BOS | 6 | 9 | - | 6.2 | 7 | 1 | 1 | 0 | 0 | 8 | 108 | 38 | 70 | 65% | 1-2 | 5.35 | 1.41 |
| 2012-07-17 | Philip Humber | R | 30 | W 7-5 | @ BOS | 13 | 41 | W | 6.0 | 6 | 2 | 2 | 0 | 0 | 3 | 110 | 35 | 75 | 68% | 4-4 | 5.79 | 1.45 |
| 2012-07-18 | Pedro Hernandez | L | 23 | L 1-10 | @ BOS | 1 | 1 | L | 4.0 | 12 | 8 | 8 | 3 | 1 | 2 | 86 | 29 | 57 | 66% | 0-1 | 18.00 | 3.25 |
| 2012-07-19 | Jose Quintana | L | 23 | L 1-3 | @ BOS | 10 | 10 | - | 8.0 | 5 | 0 | 0 | 0 | 0 | 2 | 105 | 40 | 65 | 62% | 4-1 | 2.31 | 1.03 |
| 2012-07-20 | Jake Peavy | R | 31 | L 2-4 | @ DET | 19 | 269 | L | 7.0 | 8 | 4 | 4 | 0 | 0 | 7 | 121 | 44 | 77 | 64% | 7-7 | 3.22 | 1.04 |
| 2012-07-21 | Chris Sale | L | 23 | L 1-7 | @ DET | 17 | 17 | L | 7.0 | 7 | 5 | 5 | 1 | 4 | 6 | 94 | 34 | 60 | 64% | 11-3 | 2.36 | 1.01 |
| 2012-07-22 | Philip Humber | R | 30 | L 4-6 | @ DET | 14 | 42 | L | 3.0 | 7 | 6 | 6 | 4 | 1 | 0 | 63 | 27 | 36 | 57% | 4-5 | 6.28 | 1.50 |
| 2012-07-23 | Gavin Floyd | R | 29 | L 7-4 | vs MIN | 18 | 170 | W | 6.0 | 6 | 3 | 2 | 0 | 6 | 1 | 99 | 43 | 56 | 57% | 8-8 | 4.46 | 1.32 |
| 2012-07-24 | Jose Quintana | L | 23 | L 11-4 | vs MIN | 11 | 11 | - | 6.1 | 8 | 4 | 4 | 2 | 1 | 1 | 108 | 39 | 69 | 64% | 4-1 | 2.57 | 1.05 |
| 2012-07-25 | Jake Peavy | R | 31 | L 8-2 | vs MIN | 20 | 270 | W | 6.0 | 6 | 2 | 1 | 0 | 2 | 6 | 120 | 42 | 78 | 65% | 8-7 | 3.15 | 1.06 |
| 2012-07-27 | Chris Sale | L | 23 | W 9-5 | @ TEX | 18 | 18 | W | 6.1 | 6 | 5 | 5 | 1 | 2 | 6 | 110 | 34 | 76 | 69% | 12-3 | 2.61 | 1.02 |
| 2012-07-28 | Philip Humber | R | 30 | W 5-2 | @ TEX | 15 | 43 | W | 6.0 | 4 | 1 | 1 | 1 | 2 | 4 | 108 | 44 | 64 | 59% | 5-5 | 5.93 | 1.46 |
| 2012-07-29 | Gavin Floyd | R | 30 | L 0-2 | @ TEX | 19 | 171 | L | 6.2 | 7 | 2 | 1 | 0 | 5 | 1 | 109 | 46 | 63 | 58% | 8-9 | 4.27 | 1.34 |
| 2012-07-30 | Jose Quintana | L | 24 | L 6-7 | @ MIN | 12 | 12 | - | 7.0 | 10 | 6 | 4 | 0 | 1 | 0 | 98 | 36 | 62 | 63% | 4-1 | 2.79 | 1.10 |
| 2012-07-31 | Francisco Liriano | L | 29 | W 4-3 | @ MIN | 18 | 131 | - | 6.0 | 4 | 2 | 2 | 0 | 4 | 8 | 122 | 56 | 66 | 54% | 3-10 | 5.18 | 1.43 |
| 2012-08-01 | Jake Peavy | R | 31 | W 3-2 | @ MIN | 21 | 271 | W | 8.0 | 5 | 2 | 1 | 1 | 2 | 8 | 117 | 43 | 74 | 63% | 9-7 | 3.04 | 1.05 |
| 2012-08-03 | Philip Humber | R | 30 | L 8-6 | vs ANA | 16 | 44 | - | 5.2 | 10 | 6 | 6 | 2 | 4 | 1 | 109 | 42 | 67 | 61% | 5-5 | 6.14 | 1.52 |
| 2012-08-04 | Gavin Floyd | R | 30 | W 5-6 | vs ANA | 20 | 172 | - | 6.1 | 8 | 5 | 5 | 1 | 3 | 6 | 114 | 48 | 66 | 58% | 8-9 | 4.43 | 1.37 |
| 2012-08-05 | Francisco Liriano | L | 29 | L 4-2 | vs ANA | 19 | 132 | - | 5.0 | 4 | 1 | 1 | 0 | 1 | 4 | 71 | 27 | 44 | 62% | 3-10 | 5.03 | 1.41 |
| 2012-08-06 | Chris Sale | L | 23 | L 4-2 | vs KCA | 19 | 19 | W | 8.0 | 8 | 2 | 2 | 2 | 0 | 7 | 99 | 34 | 65 | 66% | 13-3 | 2.59 | 1.02 |
| 2012-08-07 | Jake Peavy | R | 31 | W 2-5 | vs KCA | 22 | 272 | L | 6.2 | 7 | 3 | 3 | 0 | 3 | 4 | 104 | 37 | 67 | 64% | 9-8 | 3.08 | 1.06 |
| 2012-08-08 | Jose Quintana | L | 24 | W 1-2 | vs KCA | 13 | 13 | L | 7.0 | 5 | 2 | 2 | 2 | 2 | 5 | 107 | 46 | 61 | 57% | 4-2 | 2.77 | 1.09 |
| 2012-08-10 | Gavin Floyd | R | 30 | L 4-3 | vs OAK | 21 | 173 | - | 6.0 | 7 | 3 | 3 | 1 | 3 | 5 | 97 | 38 | 59 | 61% | 8-9 | 4.43 | 1.38 |
| 2012-08-11 | Francisco Liriano | L | 29 | W 7-9 | vs OAK | 20 | 133 | - | 3.1 | 7 | 6 | 6 | 0 | 3 | 5 | 75 | 31 | 44 | 59% | 3-10 | 5.37 | 1.46 |
| 2012-08-12 | Chris Sale | L | 23 | L 7-3 | vs OAK | 20 | 20 | W | 6.2 | 6 | 2 | 2 | 2 | 0 | 11 | 112 | 35 | 77 | 69% | 14-3 | 2.59 | 1.01 |
| 2012-08-13 | Jake Peavy | R | 31 | L 2-3 | @ TOR | 23 | 273 | - | 8.0 | 5 | 2 | 2 | 1 | 2 | 6 | 125 | 39 | 86 | 69% | 9-8 | 3.04 | 1.06 |
| 2012-08-14 | Jose Quintana | L | 24 | W 3-2 | @ TOR | 14 | 14 | W | 6.2 | 8 | 2 | 2 | 0 | 2 | 4 | 110 | 43 | 67 | 61% | 5-2 | 2.78 | 1.12 |
| 2012-08-15 | Gavin Floyd | R | 30 | W 9-5 | @ TOR | 22 | 174 | W | 6.0 | 8 | 4 | 3 | 1 | 0 | 8 | 89 | 27 | 62 | 70% | 9-9 | 4.43 | 1.38 |
| 2012-08-16 | Francisco Liriano | L | 29 | W 7-2 | @ TOR | 21 | 134 | W | 6.1 | 3 | 2 | 2 | 1 | 1 | 6 | 86 | 26 | 60 | 70% | 4-10 | 5.21 | 1.41 |
| 2012-08-17 | Chris Sale | L | 23 | L 2-4 | @ KCA | 21 | 21 | L | 6.2 | 9 | 4 | 4 | 2 | 4 | 5 | 119 | 49 | 70 | 59% | 14-4 | 2.73 | 1.06 |
| 2012-08-18 | Jake Peavy | R | 31 | L 4-9 | @ KCA | 24 | 274 | L | 5.1 | 9 | 5 | 3 | 1 | 1 | 6 | 114 | 40 | 74 | 65% | 9-9 | 3.11 | 1.08 |
| 2012-08-19 | Jose Quintana | L | 24 | L 2-5 | @ KCA | 15 | 15 | - | 7.0 | 9 | 2 | 2 | 0 | 4 | 5 | 115 | 52 | 63 | 55% | 5-2 | 2.77 | 1.17 |
| 2012-08-20 | Gavin Floyd | R | 30 | L 9-6 | vs NYA | 23 | 175 | - | 2.1 | 5 | 3 | 3 | 0 | 4 | 1 | 58 | 29 | 29 | 50% | 9-9 | 4.57 | 1.43 |
| 2012-08-21 | Francisco Liriano | L | 29 | L 7-3 | vs NYA | 22 | 135 | W | 6.0 | 6 | 2 | 2 | 1 | 3 | 7 | 108 | 46 | 62 | 57% | 5-10 | 5.10 | 1.42 |
| 2012-08-22 | Chris Sale | L | 23 | L 2-1 | vs NYA | 22 | 22 | W | 7.2 | 3 | 1 | 1 | 1 | 1 | 13 | 107 | 39 | 68 | 64% | 15-4 | 2.65 | 1.03 |
| 2012-08-24 | Jake Peavy | R | 31 | L 9-8 | vs SEA | 25 | 275 | - | 7.0 | 7 | 2 | 2 | 1 | 0 | 5 | 105 | 32 | 73 | 70% | 9-9 | 3.09 | 1.08 |
| 2012-08-25 | Jose Quintana | L | 24 | L 5-4 | vs SEA | 16 | 16 | - | 5.2 | 5 | 3 | 3 | 1 | 4 | 4 | 112 | 46 | 66 | 59% | 5-2 | 2.86 | 1.19 |
| 2012-08-26 | Gavin Floyd | R | 30 | L 4-3 | vs SEA | 24 | 176 | - | 2.0 | 3 | 1 | 1 | 0 | 1 | 1 | 42 | 17 | 25 | 60% | 9-9 | 4.57 | 1.43 |
| 2012-08-27 | Francisco Liriano | L | 29 | L 3-4 | @ BAL | 23 | 136 | - | 5.0 | 6 | 2 | 2 | 1 | 4 | 3 | 104 | 44 | 60 | 58% | 5-10 | 5.05 | 1.44 |
| 2012-08-28 | Chris Sale | L | 23 | L 0-6 | @ BAL | 23 | 23 | L | 4.0 | 6 | 4 | 4 | 1 | 3 | 5 | 82 | 33 | 49 | 60% | 15-5 | 2.81 | 1.06 |
| 2012-08-29 | Dylan Axelrod | R | 27 | W 8-1 | @ BAL | 7 | 10 | W | 7.1 | 3 | 1 | 1 | 0 | 4 | 5 | 112 | 47 | 65 | 58% | 2-2 | 4.89 | 1.37 |
| 2012-08-30 | Jose Quintana | L | 24 | L 3-5 | @ BAL | 17 | 17 | L | 3.2 | 7 | 5 | 5 | 2 | 1 | 1 | 76 | 30 | 46 | 61% | 5-3 | 3.16 | 1.22 |
| 2012-08-31 | Jake Peavy | R | 31 | L 4-7 | @ DET | 26 | 276 | L | 6.0 | 9 | 6 | 6 | 2 | 4 | 4 | 107 | 41 | 66 | 62% | 9-10 | 3.28 | 1.12 |
| 2012-09-01 | Francisco Liriano | L | 29 | L 1-5 | @ DET | 24 | 137 | L | 4.0 | 4 | 3 | 3 | 0 | 7 | 5 | 104 | 43 | 61 | 59% | 5-11 | 5.10 | 1.48 |
| 2012-09-02 | Chris Sale | L | 23 | L 2-4 | @ DET | 24 | 24 | L | 6.0 | 6 | 4 | 4 | 2 | 4 | 7 | 105 | 45 | 60 | 57% | 15-6 | 2.93 | 1.09 |
| 2012-09-03 | Hector Santiago | L | 25 | L 4-2 | vs MIN | 1 | 1 | W | 5.0 | 3 | 1 | 1 | 1 | 3 | 6 | 91 | 35 | 56 | 62% | 3-1 | 3.74 | 1.34 |
| 2012-09-04 | Jose Quintana | L | 24 | W 9-18 | vs MIN | 18 | 18 | L | 1.1 | 5 | 7 | 7 | 0 | 2 | 2 | 54 | 23 | 31 | 57% | 5-4 | 3.68 | 1.27 |
| 2012-09-05 | Jake Peavy | R | 31 | L 6-2 | vs MIN | 27 | 277 | W | 6.0 | 5 | 1 | 1 | 0 | 1 | 3 | 104 | 32 | 72 | 69% | 10-10 | 3.22 | 1.11 |
| 2012-09-07 | Francisco Liriano | L | 29 | W 5-7 | vs KCA | 25 | 138 | - | 5.0 | 6 | 5 | 5 | 2 | 4 | 4 | 91 | 39 | 52 | 57% | 5-11 | 5.23 | 1.50 |
| 2012-09-08 | Chris Sale | L | 23 | L 5-4 | vs KCA | 25 | 25 | W | 6.0 | 5 | 1 | 1 | 0 | 1 | 6 | 100 | 38 | 62 | 62% | 16-6 | 2.88 | 1.08 |
| 2012-09-09 | Hector Santiago | L | 25 | W 1-2 | vs KCA | 2 | 2 | - | 4.0 | 3 | 0 | 0 | 0 | 3 | 8 | 90 | 32 | 58 | 64% | 3-1 | 3.47 | 1.35 |
| 2012-09-10 | Jose Quintana | L | 24 | L 6-1 | vs DET | 19 | 19 | W | 7.2 | 7 | 1 | 1 | 0 | 2 | 7 | 112 | 44 | 68 | 61% | 6-4 | 3.51 | 1.26 |
| 2012-09-11 | Jake Peavy | R | 31 | W 3-5 | vs DET | 28 | 278 | L | 5.2 | 6 | 3 | 3 | 2 | 2 | 9 | 117 | 38 | 79 | 68% | 10-11 | 3.26 | 1.12 |
| 2012-09-12 | Gavin Floyd | R | 30 | W 6-8 | vs DET | 25 | 177 | L | 4.2 | 4 | 3 | 3 | 0 | 1 | 7 | 68 | 25 | 43 | 63% | 9-10 | 4.59 | 1.42 |
| 2012-09-14 | Chris Sale | L | 23 | W 6-0 | @ MIN | 26 | 26 | W | 6.0 | 3 | 0 | 0 | 0 | 0 | 5 | 102 | 36 | 66 | 65% | 17-6 | 2.78 | 1.06 |
| 2012-09-15 | Francisco Liriano | L | 29 | W 5-3 | @ MIN | 26 | 139 | W | 7.0 | 1 | 2 | 2 | 1 | 2 | 9 | 100 | 42 | 58 | 58% | 6-11 | 5.23 | 1.46 |
| 2012-09-16 | Jake Peavy | R | 31 | W 9-2 | @ MIN | 29 | 279 | W | 6.0 | 4 | 2 | 2 | 1 | 1 | 6 | 101 | 30 | 71 | 70% | 11-11 | 3.26 | 1.11 |
| 2012-09-17 | Jose Quintana | L | 24 | L 5-4 | vs DET | 20 | 20 | - | 4.0 | 7 | 4 | 4 | 0 | 2 | 3 | 78 | 33 | 45 | 58% | 6-4 | 3.69 | 1.29 |
| 2012-09-18 | Gavin Floyd | R | 30 | W 3-2 | @ KCA | 26 | 178 | W | 7.0 | 5 | 2 | 2 | 0 | 1 | 3 | 77 | 26 | 51 | 66% | 10-10 | 4.50 | 1.39 |
| 2012-09-19 | Chris Sale | L | 23 | L 0-3 | @ KCA | 27 | 27 | L | 6.2 | 8 | 3 | 3 | 0 | 2 | 8 | 114 | 42 | 72 | 63% | 17-7 | 2.82 | 1.08 |
| 2012-09-20 | Francisco Liriano | L | 29 | L 3-4 | @ KCA | 27 | 140 | - | 5.1 | 4 | 3 | 3 | 0 | 1 | 3 | 88 | 36 | 52 | 59% | 6-11 | 5.24 | 1.44 |
| 2012-09-21 | Jake Peavy | R | 31 | L 2-6 | @ ANA | 30 | 280 | L | 5.0 | 8 | 5 | 5 | 1 | 2 | 3 | 83 | 32 | 51 | 61% | 11-12 | 3.40 | 1.13 |
| 2012-09-22 | Jose Quintana | L | 24 | L 2-4 | @ ANA | 21 | 21 | L | 5.0 | 6 | 4 | 1 | 0 | 5 | 3 | 107 | 38 | 69 | 64% | 6-5 | 3.61 | 1.33 |
| 2012-09-23 | Gavin Floyd | R | 30 | L 1-4 | @ ANA | 27 | 179 | L | 6.0 | 7 | 4 | 4 | 1 | 1 | 8 | 83 | 34 | 49 | 59% | 10-11 | 4.56 | 1.39 |
| 2012-09-24 | Chris Sale | L | 23 | L 5-4 | vs CLE | 28 | 28 | - | 7.0 | 10 | 3 | 3 | 1 | 2 | 4 | 113 | 37 | 76 | 67% | 17-7 | 2.86 | 1.10 |
| 2012-09-25 | Francisco Liriano | L | 29 | W 3-4 | vs CLE | 28 | 141 | L | 3.2 | 7 | 4 | 4 | 1 | 2 | 4 | 73 | 28 | 45 | 62% | 6-12 | 5.33 | 1.46 |
| 2012-09-26 | Hector Santiago | L | 25 | W 4-6 | vs CLE | 3 | 3 | - | 3.1 | 5 | 3 | 3 | 0 | 4 | 2 | 78 | 31 | 47 | 60% | 3-1 | 3.71 | 1.46 |
| 2012-09-27 | Jake Peavy | R | 31 | W 2-3 | vs TBA | 31 | 281 | - | 7.1 | 4 | 2 | 2 | 1 | 1 | 6 | 115 | 43 | 72 | 63% | 11-12 | 3.37 | 1.12 |
| 2012-09-28 | Gavin Floyd | R | 30 | L 3-1 | vs TBA | 28 | 180 | W | 5.0 | 2 | 1 | 1 | 1 | 5 | 6 | 105 | 48 | 57 | 54% | 11-11 | 4.47 | 1.39 |
| 2012-09-29 | Chris Sale | L | 24 | W 4-10 | vs TBA | 29 | 29 | L | 3.1 | 7 | 5 | 5 | 1 | 3 | 7 | 82 | 37 | 45 | 55% | 17-8 | 3.05 | 1.14 |
| 2012-09-30 | Jose Quintana | L | 24 | W 2-6 | vs TBA | 22 | 22 | L | 4.0 | 6 | 4 | 4 | 2 | 3 | 3 | 85 | 39 | 46 | 54% | 6-6 | 3.77 | 1.35 |
| 2012-10-01 | Hector Santiago | L | 25 | W 11-0 | @ CLE | 4 | 4 | W | 7.0 | 1 | 0 | 0 | 0 | 1 | 10 | 105 | 30 | 75 | 71% | 4-1 | 3.34 | 1.34 |
| 2012-10-02 | Jake Peavy | R | 31 | L 3-4 | @ CLE | 32 | 282 | - | 8.0 | 3 | 3 | 3 | 2 | 1 | 8 | 109 | 36 | 73 | 67% | 11-12 | 3.37 | 1.10 |
| 2012-10-03 | Gavin Floyd | R | 30 | W 9-0 | @ CLE | 29 | 181 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 6 | 99 | 40 | 59 | 60% | 12-11 | 4.29 | 1.36 |