| 33 | Dylan Axelrod | P | MLB | 6-0 | 195 | Right | Right | 7/30/1985 | 26 | Santa Barbara,California | 2007 | 30 | 927 | SD |
|
| 15 | Gordon Beckham | 2B | MLB | 6-0 | 175 | Right | Right | 9/16/1986 | 25 | Atlanta,Georgia | 2008 | 1 | 8 | CHW |
| 40 | Brian Bruney | P | MLB | 6-3 | 230 | Right | Right | 2/17/1982 | 30 | Astoria,Oregon | 2000 | 12 | 369 | ARI |
| 26 | Jesse Crain | P | MLB | 6-1 | 200 | Right | Right | 7/5/1981 | 30 | Toronto,Ontario | 2002 | 2 | 61 | MIN |
| 50 | John Danks | P | MLB | 6-2 | 190 | Left | Left | 4/15/1985 | 27 | Austin,Texas | 2003 | 1 | 9 | TEX |
| 7 | Jordan Danks | CF | MLB | 6-5 | 210 | Left | Right | 8/7/1986 | 25 | Round Rock,Texas | 2008 | 7 | 210 | CHW |
| 30 | Alejandro De Aza | CF | MLB | 6-0 | 170 | Left | Left | 4/11/1984 | 28 | Guaymate,Dominican Republic | 2001 | UDFA | | LAD |
| 32 | Adam Dunn | DH-1B | MLB | 6-6 | 235 | Left | Right | 11/9/1979 | 32 | Houston,Texas | 1998 | 2 | 50 | CIN |
| 38 | Eduardo Escobar | 3B-2B | MLB | 5-10 | 150 | Both | Right | 1/5/1989 | 23 | Villa de Cura,Cuba | 2008 | UDFA | | CHW |
| 17 | Tyler Flowers | C | MLB | 6-4 | 220 | Right | Right | 1/24/1986 | 26 | Roswell,Georgia | 2005 | 33 | 1007 | ATL |
| 34 | Gavin Floyd | P | MLB | 6-5 | 210 | Right | Right | 1/27/1983 | 29 | Annapolis,Maryland | 2001 | 1 | 4 | PHI |
| 1 | Kosuke Fukudome | 1B | MLB | 6-1 | 185 | Left | Right | 4/26/1977 | 35 | Kagoshima,Japan | | UDFA | | |
| 38 | Hector Gimenez | C | MLB | 5-10 | 180 | Both | Right | 9/28/1982 | 29 | San Felipe,Venezuela | 1999 | UDFA | | HOU |
| 60 | Deunte Heath | P | MLB | 6-4 | 205 | Right | Right | 8/28/1985 | 26 | Atlanta,Georgia | 2006 | 19 | 580 | ATL |
| 58 | Pedro Hernandez | P | MLB | 5-10 | 200 | Left | Left | 4/12/1989 | 23 | Barquisimeto,Venezuela | 2009 | UDFA | | SD |
| 5 | Orlando Hudson | 2B-3B | MLB | 6-0 | 185 | Both | Right | 12/12/1977 | 34 | Darlington,South Carolina | 1997 | 43 | 1280 | TOR |
| 41 | Philip Humber | P | MLB | 6-4 | 210 | Right | Right | 12/21/1982 | 29 | Nacogdoches,Texas | 2004 | 1 | 3 | NYM |
| 29 | Dan Johnson | 1B | MLB | 6-2 | 220 | Left | Right | 8/10/1979 | 32 | Coon Rapids,Minnesota | 2001 | 7 | 221 | OAK |
| 65 | Nathan Jones | P | MLB | 6-5 | 190 | Right | Right | 1/28/1986 | 26 | Butler,Kentucky | 2007 | 5 | 179 | CHW |
| 14 | Paul Konerko | 1B | MLB | 6-3 | 211 | Right | Right | 3/5/1976 | 36 | Providence,Rhode Island | 1994 | 1 | 13 | LAD |
| 18 | Brent Lillibridge | 1B-SS | MLB | 5-11 | 185 | Right | Right | 9/18/1983 | 28 | Everett,Washington | 2005 | 4 | 121 | PIT |
| 58 | Francisco Liriano | P | MLB | 6-2 | 185 | Left | Left | 10/26/1983 | 28 | San Cristobal,Dominican Republic | 2000 | UDFA | | SF |
| 18 | Jose Lopez | 3B | MLB | 6-2 | 170 | Right | Right | 11/24/1983 | 28 | Barcelona,Venezuela | 2000 | UDFA | | SEA |
| 57 | Jhan Marinez | P | MLB | 6-1 | 165 | Right | Right | 8/12/1988 | 23 | Santo Domingo,Dominican Republic | 2007 | UDFA | | FLA |
| 22 | Brent Morel | 3B | MLB | 6-1 | 220 | Right | Right | 4/21/1987 | 25 | Bakersfield,California | 2008 | 3 | 86 | CHW |
| 39 | Brett Myers | P | MLB | 6-4 | 215 | Right | Right | 8/17/1980 | 31 | Jacksonville,Florida | 1999 | 1 | 12 | PHI |
| 77 | Will Ohman | P | MLB | 6-2 | 195 | Left | Left | 8/13/1977 | 34 | Frankfurt,Germany | 1998 | 8 | 226 | CHC |
| 66 | Ray Olmedo | SS-3B | MLB | 5-11 | 155 | Both | Right | 5/31/1981 | 31 | Maracay,Venezuela | 1999 | UDFA | | CIN |
| 48 | Brian Omogrosso | P | MLB | 6-4 | 230 | Right | Right | 4/24/1984 | 28 | Beaver,Pennsylvania | 2006 | 6 | 195 | CHW |
| 44 | Jake Peavy | P | MLB | 6-1 | 180 | Right | Right | 5/31/1981 | 31 | Mobile,Alabama | 1999 | 15 | 472 | SD |
| 12 | A.J. Pierzynski | C | MLB | 6-3 | 220 | Left | Right | 12/30/1976 | 35 | Bridgehampton,New York | 1994 | 3 | 71 | MIN |
| 62 | Jose Quintana | P | MLB | 6-0 | 170 | Left | Left | 1/24/1989 | 23 | Arjona,Colombia | 2010 | UDFA | | NYY |
| 10 | Alexei Ramirez | SS | MLB | 6-3 | 185 | Right | Right | 9/22/1981 | 30 | Pinar del Rio,Cuba | | UDFA | | |
| 43 | Addison Reed | P | MLB | 6-3 | 215 | Left | Left | 12/27/1988 | 23 | Montclair,California | 2010 | 3 | 95 | CHW |
| 51 | Alex Rios | RF | MLB | 6-5 | 185 | Right | Right | 2/18/1981 | 31 | Coffee,Alabama | 1999 | 1 | 19 | TOR |
| 49 | Chris Sale | P | MLB | 6-6 | 172 | Left | Left | 3/30/1989 | 23 | Lakeland,Florida | 2010 | 1 | 13 | CHW |
| 53 | Hector Santiago | P | MLB | 6-1 | 213 | Right | Left | 12/16/1987 | 24 | Newark,New Jersey | 2006 | 30 | 915 | CHW |
| 52 | Leyson Septimo | P | MLB | 6-0 | 150 | Left | Left | 7/7/1985 | 26 | Santo Domingo,Dominican Republic | 2005 | UDFA | | ARI |
| 48 | Zach Stewart | P | MLB | 6-2 | 205 | Right | Right | 9/28/1986 | 25 | Wichita Falls,Texas | 2008 | 3 | 84 | CIN |
| 52 | Eric Stults | P | MLB | 6-3 | 210 | Left | Left | 12/9/1979 | 32 | Plymouth,Indiana | 2002 | 15 | 451 | LAD |
| 37 | Matt Thornton | P | MLB | 6-6 | 220 | Left | Left | 9/15/1976 | 35 | Three Rivers,Michigan | 1998 | 1 | 22 | SEA |
| 46 | Donnie Veal | P | MLB | 6-3 | 200 | Left | Left | 9/18/1984 | 27 | Jackson,Mississippi | 2005 | 2 | 68 | CHC |
| 24 | Dayan Viciedo | LF | MLB | 5-11 | 240 | Right | Right | 3/10/1989 | 23 | Remedios,Cuba | 2009 | UDFA | | CHW |
| 28 | Dewayne Wise | LF-CF | MLB | 6-1 | 180 | Left | Left | 2/24/1978 | 34 | Columbia,South Carolina | 1997 | 5 | 158 | CIN |
| 20 | Kevin Youkilis | 3B | MLB | 6-1 | 220 | Right | Right | 3/15/1979 | 33 | Cincinnati,Ohio | 2001 | 8 | 243 | BOS |