| Central | W | L | Pct | GB |
| Cincinnati | 97 | 65 | .599 | -- |
| St. Louis | 88 | 74 | .543 | 9.0 |
| Milwaukee | 83 | 79 | .512 | 14.0 |
| Pittsburgh | 79 | 83 | .488 | 18.0 |
| Chi Cubs | 61 | 101 | .377 | 36.0 |
| Houston | 55 | 107 | .340 | 42.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-05 | Ryan Dempster | R | 35 | W 1-2 | vs WAS | 1 | 295 | - | 7.2 | 2 | 1 | 1 | 0 | 3 | 10 | 106 | 35 | 71 | 67% | 0-0 | 1.13 | 0.63 |
| 2012-04-07 | Matt Garza | R | 28 | W 4-7 | vs WAS | 1 | 150 | - | 6.0 | 5 | 2 | 2 | 1 | 1 | 5 | 88 | 33 | 55 | 63% | 0-0 | 3.00 | 1.00 |
| 2012-04-08 | Jeff Samardzija | R | 27 | L 4-3 | vs WAS | 1 | 6 | W | 8.2 | 4 | 3 | 1 | 1 | 0 | 8 | 109 | 31 | 78 | 72% | 1-0 | 1.00 | 0.44 |
| 2012-04-09 | Chris Volstad | R | 26 | W 5-7 | vs MIL | 1 | 103 | - | 5.0 | 5 | 3 | 3 | 1 | 2 | 6 | 86 | 38 | 48 | 56% | 0-0 | 5.40 | 1.40 |
| 2012-04-10 | Paul Maholm | L | 30 | W 4-7 | vs MIL | 1 | 186 | L | 4.0 | 6 | 6 | 6 | 2 | 2 | 2 | 79 | 35 | 44 | 56% | 0-1 | 13.50 | 2.00 |
| 2012-04-11 | Ryan Dempster | R | 35 | W 1-2 | vs MIL | 2 | 296 | L | 6.2 | 5 | 2 | 2 | 1 | 3 | 5 | 105 | 41 | 64 | 61% | 0-1 | 1.93 | 0.93 |
| 2012-04-12 | Matt Garza | R | 28 | L 8-0 | vs MIL | 2 | 151 | W | 8.2 | 3 | 0 | 0 | 0 | 2 | 9 | 116 | 36 | 80 | 69% | 1-0 | 1.20 | 0.73 |
| 2012-04-13 | Jeff Samardzija | R | 27 | W 9-5 | @ SLN | 2 | 7 | W | 5.0 | 10 | 5 | 5 | 0 | 1 | 5 | 102 | 39 | 63 | 62% | 2-0 | 3.86 | 1.07 |
| 2012-04-14 | Chris Volstad | R | 26 | L 1-5 | @ SLN | 2 | 104 | L | 6.0 | 6 | 4 | 3 | 0 | 0 | 4 | 103 | 40 | 63 | 61% | 0-1 | 4.91 | 1.18 |
| 2012-04-15 | Paul Maholm | L | 30 | L 3-10 | @ SLN | 2 | 187 | L | 4.0 | 6 | 6 | 6 | 1 | 1 | 2 | 70 | 28 | 42 | 60% | 0-2 | 13.50 | 1.88 |
| 2012-04-17 | Ryan Dempster | R | 35 | L 2-5 | @ MIA | 3 | 297 | - | 6.0 | 4 | 2 | 0 | 0 | 2 | 8 | 103 | 40 | 63 | 61% | 0-1 | 1.35 | 0.95 |
| 2012-04-18 | Matt Garza | R | 28 | L 1-9 | @ MIA | 3 | 152 | L | 5.0 | 7 | 6 | 6 | 2 | 3 | 7 | 91 | 37 | 54 | 59% | 1-1 | 3.60 | 1.05 |
| 2012-04-19 | Jeff Samardzija | R | 27 | L 3-5 | @ MIA | 3 | 8 | L | 3.2 | 8 | 5 | 5 | 0 | 5 | 3 | 91 | 42 | 49 | 54% | 2-1 | 5.82 | 1.65 |
| 2012-04-20 | Chris Volstad | R | 26 | W 4-9 | vs CIN | 3 | 105 | L | 5.0 | 7 | 6 | 5 | 0 | 2 | 4 | 87 | 29 | 58 | 67% | 0-2 | 6.19 | 1.38 |
| 2012-04-21 | Paul Maholm | L | 30 | L 6-1 | vs CIN | 3 | 188 | W | 6.0 | 4 | 1 | 1 | 0 | 3 | 5 | 92 | 37 | 55 | 60% | 1-2 | 8.36 | 1.57 |
| 2012-04-22 | Randy Wells | R | 30 | W 3-4 | vs CIN | 1 | 83 | - | 5.0 | 6 | 2 | 2 | 0 | 5 | 2 | 89 | 39 | 50 | 56% | 0-0 | 3.60 | 2.20 |
| 2012-04-23 | Matt Garza | R | 28 | L 3-2 | vs SLN | 4 | 153 | - | 7.0 | 4 | 2 | 2 | 0 | 3 | 5 | 100 | 41 | 59 | 59% | 1-1 | 3.33 | 1.04 |
| 2012-04-24 | Jeff Samardzija | R | 27 | L 3-2 | vs SLN | 4 | 9 | - | 6.2 | 4 | 0 | 0 | 0 | 2 | 9 | 89 | 27 | 62 | 70% | 2-1 | 4.13 | 1.42 |
| 2012-04-25 | Chris Volstad | R | 26 | W 1-5 | vs SLN | 4 | 106 | L | 6.0 | 6 | 4 | 4 | 1 | 0 | 2 | 96 | 31 | 65 | 68% | 0-3 | 6.14 | 1.27 |
| 2012-04-27 | Paul Maholm | L | 30 | W 5-1 | @ PHI | 4 | 189 | W | 6.1 | 5 | 1 | 1 | 1 | 0 | 1 | 102 | 39 | 63 | 62% | 2-2 | 6.30 | 1.35 |
| 2012-04-28 | Randy Wells | R | 30 | L 2-5 | @ PHI | 2 | 84 | L | 3.2 | 3 | 4 | 4 | 0 | 4 | 3 | 82 | 36 | 46 | 56% | 0-1 | 6.00 | 2.00 |
| 2012-04-29 | Matt Garza | R | 28 | W 5-1 | @ PHI | 5 | 154 | W | 7.0 | 1 | 0 | 0 | 0 | 1 | 10 | 104 | 37 | 67 | 64% | 2-1 | 2.65 | 0.88 |
| 2012-04-30 | Chris Volstad | R | 26 | L 4-6 | @ PHI | 5 | 107 | - | 6.0 | 8 | 4 | 4 | 0 | 3 | 4 | 87 | 29 | 58 | 67% | 0-3 | 6.11 | 1.39 |
| 2012-05-02 | Jeff Samardzija | R | 27 | W 3-1 | @ CIN | 5 | 10 | W | 7.2 | 3 | 1 | 1 | 0 | 2 | 7 | 93 | 34 | 59 | 63% | 3-1 | 3.38 | 1.22 |
| 2012-05-03 | Ryan Dempster | R | 35 | L 3-4 | @ CIN | 4 | 298 | - | 8.0 | 3 | 0 | 0 | 0 | 1 | 6 | 101 | 34 | 67 | 66% | 0-1 | 0.96 | 0.82 |
| 2012-05-04 | Paul Maholm | L | 30 | L 5-4 | vs LAN | 5 | 190 | W | 6.0 | 3 | 1 | 1 | 1 | 0 | 4 | 88 | 29 | 59 | 67% | 3-2 | 5.19 | 1.15 |
| 2012-05-05 | Chris Volstad | R | 26 | W 1-5 | vs LAN | 6 | 108 | L | 5.0 | 4 | 5 | 5 | 0 | 3 | 1 | 81 | 33 | 48 | 59% | 0-4 | 6.55 | 1.39 |
| 2012-05-06 | Travis Wood | L | 25 | L 4-3 | vs LAN | 1 | 36 | - | 6.0 | 3 | 3 | 3 | 1 | 3 | 4 | 100 | 35 | 65 | 65% | 0-0 | 4.50 | 1.00 |
| 2012-05-07 | Jeff Samardzija | R | 27 | L 5-1 | vs ATL | 6 | 11 | W | 7.0 | 5 | 1 | 1 | 1 | 2 | 7 | 105 | 39 | 66 | 63% | 4-1 | 3.00 | 1.18 |
| 2012-05-08 | Ryan Dempster | R | 35 | W 1-3 | vs ATL | 5 | 299 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 7 | 100 | 39 | 61 | 61% | 0-1 | 1.03 | 0.86 |
| 2012-05-09 | Paul Maholm | L | 30 | L 1-0 | vs ATL | 6 | 191 | W | 7.0 | 3 | 0 | 0 | 0 | 3 | 3 | 95 | 31 | 64 | 67% | 4-2 | 4.09 | 1.09 |
| 2012-05-11 | Matt Garza | R | 28 | L 7-8 | @ MIL | 6 | 155 | - | 5.0 | 3 | 1 | 1 | 0 | 5 | 3 | 91 | 42 | 49 | 54% | 2-1 | 2.54 | 0.97 |
| 2012-05-12 | Chris Volstad | R | 26 | L 2-8 | @ MIL | 7 | 109 | L | 6.0 | 9 | 6 | 6 | 1 | 2 | 1 | 99 | 36 | 63 | 64% | 0-5 | 6.92 | 1.46 |
| 2012-05-13 | Jeff Samardzija | R | 27 | W 8-2 | @ MIL | 7 | 12 | - | 5.0 | 3 | 1 | 1 | 0 | 2 | 6 | 92 | 34 | 58 | 63% | 4-1 | 2.86 | 1.16 |
| 2012-05-14 | Ryan Dempster | R | 35 | W 6-4 | @ SLN | 6 | 300 | - | 6.0 | 9 | 4 | 4 | 0 | 1 | 5 | 93 | 32 | 61 | 66% | 0-1 | 1.76 | 0.98 |
| 2012-05-15 | Paul Maholm | L | 30 | L 6-7 | @ SLN | 7 | 192 | - | 6.0 | 7 | 4 | 4 | 1 | 3 | 5 | 106 | 37 | 69 | 65% | 4-2 | 4.38 | 1.18 |
| 2012-05-16 | Matt Garza | R | 29 | W 2-9 | vs PHI | 7 | 156 | - | 6.2 | 8 | 2 | 2 | 0 | 1 | 2 | 107 | 37 | 70 | 65% | 2-1 | 2.60 | 1.04 |
| 2012-05-17 | Chris Volstad | R | 26 | W 7-8 | vs PHI | 8 | 110 | L | 2.0 | 6 | 4 | 4 | 0 | 3 | 2 | 58 | 26 | 32 | 55% | 0-6 | 7.46 | 1.61 |
| 2012-05-18 | Jeff Samardzija | R | 27 | W 2-3 | vs CHA | 8 | 13 | L | 7.1 | 6 | 3 | 3 | 2 | 2 | 8 | 113 | 35 | 78 | 69% | 4-2 | 3.00 | 1.16 |
| 2012-05-19 | Ryan Dempster | R | 35 | W 4-7 | vs CHA | 7 | 301 | L | 6.0 | 7 | 4 | 4 | 2 | 3 | 3 | 90 | 36 | 54 | 60% | 0-2 | 2.30 | 1.06 |
| 2012-05-20 | Paul Maholm | L | 30 | W 0-6 | vs CHA | 8 | 193 | L | 6.1 | 9 | 5 | 5 | 3 | 0 | 5 | 96 | 30 | 66 | 69% | 4-3 | 4.70 | 1.20 |
| 2012-05-21 | Matt Garza | R | 29 | L 4-8 | @ HOU | 8 | 157 | L | 3.0 | 5 | 7 | 7 | 2 | 2 | 2 | 72 | 30 | 42 | 58% | 2-2 | 3.75 | 1.13 |
| 2012-05-22 | Travis Wood | L | 25 | L 1-2 | @ HOU | 2 | 37 | L | 5.2 | 2 | 2 | 2 | 1 | 2 | 3 | 96 | 43 | 53 | 55% | 0-1 | 3.75 | 0.83 |
| 2012-05-23 | Jeff Samardzija | R | 27 | L 1-5 | @ HOU | 9 | 14 | L | 6.0 | 6 | 2 | 2 | 0 | 2 | 4 | 88 | 32 | 56 | 64% | 4-3 | 3.00 | 1.18 |
| 2012-05-25 | Ryan Dempster | R | 35 | L 0-1 | @ PIT | 8 | 302 | L | 7.1 | 7 | 1 | 1 | 0 | 1 | 6 | 109 | 35 | 74 | 68% | 0-3 | 2.13 | 1.05 |
| 2012-05-26 | Paul Maholm | L | 30 | L 2-3 | @ PIT | 9 | 194 | - | 5.0 | 4 | 2 | 2 | 0 | 5 | 2 | 103 | 47 | 56 | 54% | 4-3 | 4.59 | 1.25 |
| 2012-05-27 | Matt Garza | R | 29 | L 4-10 | @ PIT | 9 | 158 | L | 5.0 | 7 | 6 | 5 | 3 | 1 | 6 | 91 | 25 | 66 | 73% | 2-3 | 4.25 | 1.17 |
| 2012-05-28 | Travis Wood | L | 25 | L 11-7 | vs SDN | 3 | 38 | - | 5.0 | 7 | 6 | 6 | 4 | 3 | 4 | 83 | 34 | 49 | 59% | 0-1 | 5.82 | 1.18 |
| 2012-05-29 | Jeff Samardzija | R | 27 | L 5-3 | vs SDN | 10 | 15 | W | 7.0 | 8 | 3 | 3 | 1 | 1 | 8 | 92 | 33 | 59 | 64% | 5-3 | 3.09 | 1.19 |
| 2012-05-30 | Ryan Dempster | R | 35 | L 8-6 | vs SDN | 9 | 303 | - | 4.1 | 6 | 6 | 6 | 3 | 4 | 4 | 98 | 41 | 57 | 58% | 0-3 | 2.90 | 1.15 |
| 2012-06-01 | Paul Maholm | L | 30 | L 3-4 | @ SFN | 10 | 195 | L | 5.1 | 8 | 4 | 4 | 0 | 2 | 4 | 88 | 30 | 58 | 66% | 4-4 | 4.82 | 1.32 |
| 2012-06-02 | Matt Garza | R | 29 | L 1-2 | @ SFN | 10 | 159 | L | 6.0 | 5 | 2 | 2 | 0 | 1 | 6 | 102 | 40 | 62 | 61% | 2-4 | 4.12 | 1.15 |
| 2012-06-03 | Travis Wood | L | 25 | L 0-2 | @ SFN | 4 | 39 | L | 7.0 | 3 | 1 | 1 | 0 | 2 | 7 | 103 | 37 | 66 | 64% | 0-2 | 4.50 | 1.04 |
| 2012-06-04 | Jeff Samardzija | R | 27 | L 2-3 | @ SFN | 11 | 16 | - | 5.0 | 7 | 2 | 2 | 0 | 5 | 6 | 115 | 47 | 68 | 59% | 5-3 | 3.13 | 1.28 |
| 2012-06-05 | Ryan Dempster | R | 35 | W 10-0 | @ MIL | 10 | 304 | W | 7.0 | 3 | 0 | 0 | 0 | 0 | 3 | 101 | 33 | 68 | 67% | 1-3 | 2.59 | 1.08 |
| 2012-06-06 | Paul Maholm | L | 30 | L 0-8 | @ MIL | 11 | 196 | L | 4.0 | 6 | 4 | 4 | 0 | 1 | 3 | 81 | 32 | 49 | 60% | 4-5 | 5.10 | 1.35 |
| 2012-06-07 | Matt Garza | R | 29 | L 3-4 | @ MIL | 11 | 160 | - | 6.0 | 4 | 2 | 2 | 1 | 1 | 6 | 96 | 37 | 59 | 61% | 2-4 | 4.02 | 1.12 |
| 2012-06-08 | Travis Wood | L | 25 | L 7-8 | @ MIN | 5 | 40 | - | 5.0 | 6 | 3 | 3 | 1 | 3 | 3 | 90 | 41 | 49 | 54% | 0-2 | 4.66 | 1.17 |
| 2012-06-09 | Jeff Samardzija | R | 27 | L 3-11 | @ MIN | 12 | 17 | L | 3.2 | 9 | 8 | 8 | 0 | 1 | 1 | 79 | 27 | 52 | 66% | 5-4 | 3.95 | 1.34 |
| 2012-06-10 | Ryan Dempster | R | 35 | W 8-2 | @ MIN | 11 | 305 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 6 | 118 | 38 | 80 | 68% | 2-3 | 2.31 | 1.03 |
| 2012-06-12 | Paul Maholm | L | 30 | L 4-3 | vs DET | 12 | 197 | - | 6.0 | 6 | 2 | 2 | 0 | 1 | 7 | 87 | 30 | 57 | 66% | 4-5 | 4.91 | 1.33 |
| 2012-06-13 | Matt Garza | R | 29 | W 4-8 | vs DET | 12 | 161 | L | 6.0 | 7 | 5 | 3 | 0 | 0 | 5 | 94 | 24 | 70 | 74% | 2-5 | 4.06 | 1.13 |
| 2012-06-14 | Travis Wood | L | 25 | W 3-5 | vs DET | 6 | 41 | L | 6.2 | 8 | 3 | 3 | 0 | 2 | 3 | 98 | 37 | 61 | 62% | 0-3 | 4.63 | 1.26 |
| 2012-06-15 | Ryan Dempster | R | 35 | L 3-0 | vs BOS | 12 | 306 | W | 7.0 | 5 | 0 | 0 | 0 | 2 | 3 | 105 | 37 | 68 | 65% | 3-3 | 2.11 | 1.02 |
| 2012-06-16 | Jeff Samardzija | R | 27 | W 3-4 | vs BOS | 13 | 18 | L | 5.1 | 4 | 3 | 3 | 1 | 3 | 6 | 106 | 41 | 65 | 61% | 5-5 | 4.04 | 1.35 |
| 2012-06-17 | Paul Maholm | L | 30 | W 4-7 | vs BOS | 13 | 198 | - | 6.0 | 6 | 3 | 3 | 1 | 1 | 6 | 95 | 35 | 60 | 63% | 4-5 | 4.88 | 1.32 |
| 2012-06-18 | Matt Garza | R | 29 | W 12-3 | @ CHA | 13 | 162 | W | 6.0 | 5 | 3 | 3 | 2 | 1 | 6 | 86 | 28 | 58 | 67% | 3-5 | 4.09 | 1.12 |
| 2012-06-19 | Travis Wood | L | 25 | W 2-1 | @ CHA | 7 | 42 | W | 6.0 | 4 | 1 | 1 | 0 | 4 | 5 | 90 | 42 | 48 | 53% | 1-3 | 4.17 | 1.27 |
| 2012-06-20 | Randy Wells | R | 30 | L 0-7 | @ CHA | 3 | 85 | L | 3.2 | 5 | 3 | 3 | 0 | 4 | 0 | 71 | 29 | 42 | 59% | 1-2 | 4.85 | 1.88 |
| 2012-06-22 | Jeff Samardzija | R | 27 | L 1-6 | @ ARI | 14 | 19 | L | 5.0 | 7 | 5 | 5 | 1 | 2 | 6 | 85 | 29 | 56 | 66% | 5-6 | 4.34 | 1.37 |
| 2012-06-23 | Paul Maholm | L | 30 | L 5-10 | @ ARI | 14 | 199 | L | 3.1 | 9 | 7 | 6 | 1 | 3 | 0 | 93 | 39 | 54 | 58% | 4-6 | 5.40 | 1.43 |
| 2012-06-24 | Matt Garza | R | 29 | L 1-5 | @ ARI | 14 | 163 | L | 7.0 | 5 | 3 | 3 | 1 | 1 | 7 | 104 | 32 | 72 | 69% | 3-6 | 4.07 | 1.10 |
| 2012-06-25 | Travis Wood | L | 25 | L 6-1 | vs NYN | 8 | 43 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 6 | 93 | 23 | 70 | 75% | 2-3 | 3.56 | 1.21 |
| 2012-06-26 | Randy Wells | R | 30 | L 5-3 | vs NYN | 4 | 86 | - | 3.0 | 6 | 3 | 3 | 0 | 4 | 3 | 78 | 36 | 42 | 54% | 1-2 | 5.28 | 2.03 |
| 2012-06-27 | Jeff Samardzija | R | 27 | W 1-17 | vs NYN | 15 | 20 | L | 4.1 | 6 | 9 | 9 | 2 | 4 | 1 | 71 | 33 | 38 | 54% | 5-7 | 5.07 | 1.43 |
| 2012-06-29 | Paul Maholm | L | 30 | L 4-0 | vs HOU | 15 | 200 | W | 8.1 | 4 | 0 | 0 | 0 | 1 | 6 | 98 | 31 | 67 | 68% | 5-6 | 4.82 | 1.33 |
| 2012-06-30 | Matt Garza | R | 29 | L 3-2 | vs HOU | 15 | 164 | W | 5.1 | 9 | 2 | 2 | 0 | 3 | 1 | 103 | 35 | 68 | 66% | 4-6 | 4.00 | 1.16 |
| 2012-07-01 | Travis Wood | L | 25 | L 3-0 | vs HOU | 9 | 44 | W | 7.2 | 3 | 0 | 0 | 0 | 0 | 4 | 103 | 33 | 70 | 68% | 3-3 | 3.05 | 1.09 |
| 2012-07-02 | Jeff Samardzija | R | 27 | W 4-1 | @ ATL | 16 | 21 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 11 | 108 | 39 | 69 | 64% | 6-7 | 4.79 | 1.37 |
| 2012-07-03 | Chris Volstad | R | 26 | L 3-10 | @ ATL | 9 | 111 | L | 4.1 | 7 | 6 | 6 | 1 | 2 | 3 | 80 | 31 | 49 | 61% | 0-7 | 8.00 | 1.67 |
| 2012-07-04 | Paul Maholm | L | 30 | W 5-1 | @ ATL | 16 | 201 | W | 6.0 | 8 | 1 | 1 | 0 | 1 | 5 | 96 | 33 | 63 | 66% | 6-6 | 4.60 | 1.34 |
| 2012-07-05 | Matt Garza | R | 29 | L 3-7 | @ ATL | 16 | 165 | L | 4.0 | 5 | 5 | 5 | 3 | 3 | 6 | 92 | 29 | 63 | 68% | 4-7 | 4.31 | 1.19 |
| 2012-07-06 | Travis Wood | L | 25 | W 8-7 | @ NYN | 10 | 45 | W | 6.0 | 5 | 3 | 2 | 1 | 4 | 3 | 103 | 41 | 62 | 60% | 4-3 | 3.05 | 1.13 |
| 2012-07-07 | Jeff Samardzija | R | 27 | L 1-3 | @ NYN | 17 | 22 | L | 7.0 | 7 | 3 | 3 | 2 | 2 | 4 | 102 | 37 | 65 | 64% | 6-8 | 4.72 | 1.37 |
| 2012-07-08 | Ryan Dempster | R | 35 | W 7-0 | @ NYN | 13 | 307 | W | 5.0 | 4 | 0 | 0 | 0 | 0 | 4 | 64 | 18 | 46 | 72% | 4-3 | 1.99 | 1.01 |
| 2012-07-13 | Paul Maholm | L | 30 | L 8-1 | vs ARI | 17 | 202 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 5 | 100 | 36 | 64 | 64% | 7-6 | 4.32 | 1.33 |
| 2012-07-14 | Ryan Dempster | R | 35 | L 4-1 | vs ARI | 14 | 308 | W | 6.0 | 4 | 0 | 0 | 0 | 3 | 5 | 88 | 33 | 55 | 63% | 5-3 | 1.86 | 1.02 |
| 2012-07-15 | Matt Garza | R | 29 | L 3-1 | vs ARI | 17 | 166 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 7 | 107 | 41 | 66 | 62% | 5-7 | 4.01 | 1.17 |
| 2012-07-17 | Travis Wood | L | 25 | W 5-9 | vs MIA | 11 | 46 | L | 4.2 | 8 | 8 | 8 | 2 | 2 | 6 | 93 | 35 | 58 | 62% | 4-4 | 3.90 | 1.19 |
| 2012-07-18 | Jeff Samardzija | R | 27 | L 5-1 | vs MIA | 18 | 23 | - | 5.0 | 6 | 1 | 1 | 1 | 3 | 9 | 96 | 31 | 65 | 68% | 6-8 | 4.58 | 1.39 |
| 2012-07-19 | Paul Maholm | L | 30 | L 4-2 | vs MIA | 18 | 203 | W | 8.0 | 5 | 1 | 1 | 0 | 1 | 4 | 106 | 38 | 68 | 64% | 8-6 | 4.08 | 1.28 |
| 2012-07-20 | Ryan Dempster | R | 35 | L 1-4 | @ SLN | 15 | 309 | L | 6.0 | 7 | 4 | 4 | 1 | 2 | 2 | 94 | 30 | 64 | 68% | 5-4 | 2.11 | 1.05 |
| 2012-07-21 | Matt Garza | R | 29 | L 0-12 | @ SLN | 18 | 167 | - | 3.0 | 2 | 0 | 0 | 0 | 2 | 3 | 33 | 11 | 22 | 67% | 5-7 | 3.89 | 1.17 |
| 2012-07-22 | Travis Wood | L | 25 | L 0-7 | @ SLN | 12 | 47 | L | 6.0 | 9 | 7 | 6 | 2 | 2 | 4 | 104 | 38 | 66 | 63% | 4-5 | 4.32 | 1.25 |
| 2012-07-23 | Jeff Samardzija | R | 27 | W 2-0 | @ PIT | 19 | 24 | W | 8.0 | 1 | 0 | 0 | 0 | 1 | 5 | 104 | 31 | 73 | 70% | 7-8 | 4.26 | 1.31 |
| 2012-07-24 | Paul Maholm | L | 30 | W 5-1 | @ PIT | 19 | 204 | W | 8.0 | 4 | 1 | 1 | 1 | 1 | 7 | 110 | 40 | 70 | 64% | 9-6 | 3.87 | 1.24 |
| 2012-07-25 | Ryan Dempster | R | 35 | L 2-3 | @ PIT | 16 | 310 | L | 6.0 | 5 | 3 | 3 | 2 | 0 | 6 | 91 | 29 | 62 | 68% | 5-5 | 2.25 | 1.04 |
| 2012-07-27 | Travis Wood | L | 25 | W 6-9 | vs SLN | 13 | 48 | L | 5.0 | 7 | 8 | 8 | 5 | 2 | 2 | 83 | 33 | 50 | 60% | 4-6 | 4.96 | 1.28 |
| 2012-07-28 | Jeff Samardzija | R | 28 | L 3-2 | vs SLN | 20 | 25 | - | 6.0 | 3 | 2 | 2 | 0 | 6 | 7 | 103 | 46 | 57 | 55% | 7-8 | 4.20 | 1.32 |
| 2012-07-29 | Paul Maholm | L | 30 | L 4-2 | vs SLN | 20 | 205 | - | 6.2 | 4 | 1 | 1 | 0 | 4 | 5 | 114 | 54 | 60 | 53% | 9-6 | 3.75 | 1.24 |
| 2012-07-30 | Justin Germano | R | 30 | L 14-4 | vs PIT | 1 | 37 | W | 5.0 | 4 | 2 | 2 | 0 | 2 | 3 | 65 | 20 | 45 | 69% | 1-1 | 1.93 | 1.29 |
| 2012-07-31 | Casey Coleman | R | 25 | W 0-5 | vs PIT | 1 | 26 | L | 4.2 | 7 | 4 | 4 | 1 | 4 | 5 | 104 | 46 | 58 | 56% | 0-2 | 7.50 | 2.04 |
| 2012-08-01 | Travis Wood | L | 25 | W 4-8 | vs PIT | 14 | 49 | L | 5.0 | 3 | 2 | 2 | 1 | 3 | 6 | 96 | 40 | 56 | 58% | 4-7 | 4.88 | 1.28 |
| 2012-08-03 | Jeff Samardzija | R | 28 | L 1-6 | @ LAN | 21 | 26 | L | 5.1 | 8 | 5 | 5 | 1 | 0 | 3 | 95 | 32 | 63 | 66% | 7-9 | 4.36 | 1.32 |
| 2012-08-04 | Chris Volstad | R | 26 | L 1-3 | @ LAN | 10 | 112 | L | 7.0 | 6 | 2 | 2 | 1 | 1 | 3 | 100 | 33 | 67 | 67% | 0-8 | 7.27 | 1.58 |
| 2012-08-05 | Justin Germano | R | 30 | L 6-7 | @ LAN | 2 | 38 | - | 5.1 | 3 | 2 | 2 | 0 | 0 | 3 | 76 | 29 | 47 | 62% | 1-1 | 2.37 | 1.11 |
| 2012-08-06 | Travis Wood | L | 25 | L 0-2 | @ SDN | 15 | 50 | L | 6.0 | 5 | 2 | 2 | 0 | 3 | 3 | 96 | 45 | 51 | 53% | 4-8 | 4.75 | 1.28 |
| 2012-08-07 | Brooks Raley | L | 24 | L 4-7 | @ SDN | 1 | 1 | L | 4.0 | 8 | 7 | 7 | 1 | 3 | 4 | 88 | 35 | 53 | 60% | 0-1 | 15.75 | 2.75 |
| 2012-08-08 | Jeff Samardzija | R | 28 | L 0-2 | @ SDN | 22 | 27 | L | 7.0 | 4 | 1 | 1 | 0 | 2 | 6 | 116 | 49 | 67 | 58% | 7-10 | 4.20 | 1.29 |
| 2012-08-09 | Chris Volstad | R | 26 | L 5-3 | vs CIN | 11 | 113 | - | 6.0 | 6 | 3 | 3 | 2 | 2 | 4 | 99 | 37 | 62 | 63% | 0-8 | 6.98 | 1.55 |
| 2012-08-10 | Justin Germano | R | 30 | W 8-10 | vs CIN | 3 | 39 | L | 5.2 | 7 | 6 | 4 | 1 | 2 | 2 | 90 | 33 | 57 | 63% | 1-2 | 3.24 | 1.20 |
| 2012-08-11 | Travis Wood | L | 26 | W 2-4 | vs CIN | 16 | 51 | - | 7.0 | 5 | 1 | 1 | 0 | 1 | 8 | 99 | 30 | 69 | 70% | 4-8 | 4.50 | 1.25 |
| 2012-08-12 | Brooks Raley | L | 24 | W 0-3 | vs CIN | 2 | 2 | L | 6.0 | 5 | 3 | 3 | 2 | 1 | 2 | 83 | 32 | 51 | 61% | 0-2 | 9.00 | 1.70 |
| 2012-08-13 | Jeff Samardzija | R | 28 | L 7-1 | vs HOU | 23 | 28 | W | 7.0 | 4 | 1 | 1 | 1 | 3 | 11 | 107 | 40 | 67 | 63% | 8-10 | 4.05 | 1.28 |
| 2012-08-14 | Chris Volstad | R | 26 | W 1-10 | vs HOU | 12 | 114 | L | 5.0 | 8 | 4 | 4 | 1 | 0 | 3 | 70 | 23 | 47 | 67% | 0-9 | 7.00 | 1.56 |
| 2012-08-15 | Justin Germano | R | 30 | L 7-2 | vs HOU | 4 | 40 | W | 6.1 | 5 | 2 | 2 | 1 | 1 | 6 | 91 | 33 | 58 | 64% | 2-2 | 3.19 | 1.16 |
| 2012-08-17 | Travis Wood | L | 26 | L 3-7 | @ CIN | 17 | 52 | L | 5.0 | 9 | 7 | 6 | 3 | 0 | 3 | 98 | 29 | 69 | 70% | 4-9 | 4.81 | 1.28 |
| 2012-08-18 | Jeff Samardzija | R | 28 | L 3-5 | @ CIN | 24 | 29 | L | 5.0 | 6 | 4 | 4 | 3 | 0 | 5 | 91 | 28 | 63 | 69% | 8-11 | 4.16 | 1.28 |
| 2012-08-18 | Brooks Raley | L | 24 | W 9-7 | @ CIN | 3 | 3 | W | 5.1 | 5 | 4 | 3 | 1 | 2 | 4 | 77 | 27 | 50 | 65% | 1-2 | 7.80 | 1.60 |
| 2012-08-19 | Chris Volstad | R | 26 | L 4-5 | @ CIN | 13 | 115 | - | 6.0 | 7 | 4 | 4 | 0 | 1 | 4 | 97 | 37 | 60 | 62% | 0-9 | 6.91 | 1.54 |
| 2012-08-20 | Justin Germano | R | 30 | L 5-9 | @ MIL | 5 | 41 | L | 4.2 | 8 | 7 | 7 | 1 | 1 | 3 | 91 | 37 | 54 | 59% | 2-3 | 4.50 | 1.25 |
| 2012-08-21 | Chris Rusin | L | 26 | L 2-5 | @ MIL | 1 | 1 | L | 5.0 | 1 | 1 | 1 | 0 | 2 | 4 | 79 | 38 | 41 | 52% | 0-1 | 1.80 | 0.60 |
| 2012-08-22 | Travis Wood | L | 26 | L 2-3 | @ MIL | 18 | 53 | L | 7.0 | 6 | 3 | 3 | 1 | 1 | 6 | 100 | 32 | 68 | 68% | 4-10 | 4.75 | 1.26 |
| 2012-08-24 | Jeff Samardzija | R | 28 | L 5-3 | vs COL | 25 | 30 | - | 7.0 | 6 | 3 | 2 | 2 | 2 | 7 | 96 | 35 | 61 | 64% | 8-11 | 4.09 | 1.27 |
| 2012-08-25 | Brooks Raley | L | 24 | W 3-4 | vs COL | 4 | 4 | - | 5.0 | 5 | 2 | 2 | 1 | 3 | 4 | 80 | 37 | 43 | 54% | 1-2 | 6.75 | 1.60 |
| 2012-08-26 | Chris Volstad | R | 26 | L 5-0 | vs COL | 14 | 116 | W | 6.2 | 3 | 0 | 0 | 0 | 3 | 3 | 101 | 41 | 60 | 59% | 1-9 | 6.28 | 1.47 |
| 2012-08-27 | Justin Germano | R | 30 | W 4-15 | vs MIL | 6 | 42 | L | 5.0 | 10 | 5 | 5 | 1 | 0 | 4 | 92 | 33 | 59 | 64% | 2-4 | 5.05 | 1.34 |
| 2012-08-28 | Travis Wood | L | 26 | W 1-4 | vs MIL | 19 | 54 | L | 7.0 | 5 | 3 | 3 | 1 | 0 | 4 | 94 | 37 | 57 | 61% | 4-11 | 4.70 | 1.23 |
| 2012-08-29 | Jeff Samardzija | R | 28 | W 1-3 | vs MIL | 26 | 31 | L | 7.0 | 7 | 3 | 2 | 0 | 0 | 10 | 104 | 33 | 71 | 68% | 8-12 | 4.02 | 1.26 |
| 2012-08-30 | Brooks Raley | L | 24 | L 12-11 | vs MIL | 5 | 5 | - | 4.0 | 10 | 7 | 7 | 2 | 2 | 2 | 86 | 38 | 48 | 56% | 1-2 | 8.25 | 1.83 |
| 2012-08-31 | Chris Volstad | R | 26 | L 6-4 | vs SFN | 15 | 117 | W | 5.2 | 5 | 2 | 2 | 0 | 3 | 2 | 88 | 39 | 49 | 56% | 2-9 | 6.04 | 1.46 |
| 2012-09-01 | Justin Germano | R | 30 | W 2-5 | vs SFN | 7 | 43 | L | 5.0 | 6 | 5 | 5 | 0 | 2 | 2 | 93 | 36 | 57 | 61% | 2-5 | 5.48 | 1.37 |
| 2012-09-02 | Travis Wood | L | 26 | W 5-7 | vs SFN | 20 | 55 | - | 5.2 | 7 | 4 | 2 | 0 | 1 | 2 | 102 | 36 | 66 | 65% | 4-11 | 4.65 | 1.24 |
| 2012-09-03 | Jeff Samardzija | R | 28 | L 1-2 | @ WAS | 27 | 32 | L | 7.0 | 7 | 1 | 1 | 1 | 1 | 8 | 111 | 42 | 69 | 62% | 8-13 | 3.90 | 1.25 |
| 2012-09-04 | Chris Rusin | L | 26 | L 5-11 | @ WAS | 2 | 2 | L | 1.0 | 8 | 5 | 5 | 2 | 1 | 1 | 43 | 16 | 27 | 63% | 0-2 | 9.00 | 2.00 |
| 2012-09-05 | Chris Volstad | R | 26 | L 1-9 | @ WAS | 16 | 118 | L | 5.0 | 9 | 5 | 5 | 3 | 4 | 2 | 91 | 44 | 47 | 52% | 2-10 | 6.21 | 1.53 |
| 2012-09-06 | Justin Germano | R | 30 | L 2-9 | @ WAS | 8 | 44 | L | 4.0 | 7 | 7 | 6 | 1 | 2 | 2 | 78 | 33 | 45 | 58% | 2-6 | 6.12 | 1.44 |
| 2012-09-07 | Travis Wood | L | 26 | W 12-2 | @ PIT | 21 | 56 | W | 6.0 | 1 | 0 | 0 | 0 | 3 | 5 | 83 | 31 | 52 | 63% | 5-11 | 4.43 | 1.21 |
| 2012-09-08 | Jeff Samardzija | R | 28 | W 4-3 | @ PIT | 28 | 33 | W | 9.0 | 4 | 3 | 2 | 0 | 1 | 9 | 120 | 39 | 81 | 68% | 9-13 | 3.81 | 1.22 |
| 2012-09-09 | Chris Rusin | L | 26 | W 4-2 | @ PIT | 3 | 3 | - | 5.0 | 5 | 1 | 1 | 1 | 3 | 4 | 79 | 31 | 48 | 61% | 0-2 | 5.73 | 1.82 |
| 2012-09-10 | Chris Volstad | R | 26 | W 4-1 | @ HOU | 17 | 119 | W | 5.0 | 4 | 1 | 1 | 0 | 5 | 4 | 102 | 45 | 57 | 56% | 3-10 | 5.97 | 1.54 |
| 2012-09-11 | Justin Germano | R | 30 | L 0-1 | @ HOU | 9 | 45 | L | 5.0 | 3 | 1 | 0 | 0 | 2 | 8 | 83 | 31 | 52 | 63% | 2-7 | 5.56 | 1.40 |
| 2012-09-12 | Travis Wood | L | 26 | W 5-1 | @ HOU | 22 | 57 | W | 7.2 | 4 | 1 | 1 | 0 | 1 | 6 | 108 | 37 | 71 | 66% | 6-11 | 4.23 | 1.18 |
| 2012-09-14 | Chris Rusin | L | 26 | L 7-4 | vs PIT | 4 | 4 | W | 5.0 | 4 | 2 | 2 | 0 | 0 | 6 | 78 | 22 | 56 | 72% | 1-2 | 5.06 | 1.50 |
| 2012-09-15 | Jason Berken | R | 29 | W 6-7 | vs PIT | 1 | 25 | L | 4.0 | 8 | 6 | 2 | 1 | 1 | 2 | 77 | 31 | 46 | 60% | 0-1 | 7.20 | 3.20 |
| 2012-09-16 | Chris Volstad | R | 26 | L 13-9 | vs PIT | 18 | 120 | - | 4.2 | 10 | 6 | 6 | 2 | 4 | 3 | 100 | 46 | 54 | 54% | 3-10 | 6.28 | 1.63 |
| 2012-09-17 | Travis Wood | L | 26 | W 0-3 | vs PIT | 23 | 58 | L | 5.2 | 4 | 3 | 3 | 0 | 1 | 9 | 115 | 49 | 66 | 57% | 6-12 | 4.24 | 1.16 |
| 2012-09-18 | Justin Germano | R | 30 | W 1-3 | vs CIN | 10 | 46 | L | 5.0 | 3 | 3 | 3 | 0 | 5 | 3 | 87 | 37 | 50 | 57% | 2-8 | 5.55 | 1.42 |
| 2012-09-19 | Chris Rusin | L | 26 | W 5-6 | vs CIN | 5 | 5 | - | 5.0 | 10 | 5 | 5 | 0 | 2 | 2 | 87 | 33 | 54 | 62% | 1-2 | 6.00 | 1.71 |
| 2012-09-20 | Jason Berken | R | 29 | W 3-5 | vs CIN | 2 | 26 | - | 6.0 | 2 | 0 | 0 | 0 | 2 | 5 | 86 | 32 | 54 | 63% | 0-1 | 3.27 | 1.82 |
| 2012-09-21 | Chris Volstad | R | 26 | L 5-4 | vs SLN | 19 | 121 | - | 5.0 | 6 | 3 | 3 | 0 | 3 | 0 | 115 | 48 | 67 | 58% | 3-10 | 6.24 | 1.63 |
| 2012-09-22 | Travis Wood | L | 26 | W 4-5 | vs SLN | 24 | 59 | - | 5.0 | 6 | 3 | 2 | 0 | 2 | 7 | 96 | 36 | 60 | 63% | 6-12 | 4.22 | 1.18 |
| 2012-09-23 | Justin Germano | R | 30 | W 3-6 | vs SLN | 11 | 47 | L | 5.2 | 10 | 4 | 4 | 1 | 1 | 3 | 97 | 34 | 63 | 65% | 2-9 | 5.68 | 1.48 |
| 2012-09-25 | Chris Rusin | L | 26 | L 5-10 | @ COL | 6 | 6 | L | 3.2 | 7 | 6 | 6 | 1 | 1 | 0 | 72 | 30 | 42 | 58% | 1-3 | 7.20 | 1.76 |
| 2012-09-26 | Jason Berken | R | 29 | L 0-6 | @ COL | 3 | 27 | L | 4.0 | 9 | 6 | 6 | 1 | 2 | 2 | 75 | 30 | 45 | 60% | 0-2 | 6.00 | 2.07 |
| 2012-09-27 | Chris Volstad | R | 26 | L 5-7 | @ COL | 20 | 122 | L | 3.0 | 10 | 7 | 7 | 2 | 0 | 0 | 67 | 25 | 42 | 63% | 3-11 | 6.66 | 1.68 |
| 2012-09-28 | Travis Wood | L | 26 | L 3-8 | @ ARI | 25 | 60 | L | 5.0 | 5 | 5 | 5 | 2 | 3 | 2 | 75 | 24 | 51 | 68% | 6-13 | 4.38 | 1.19 |
| 2012-09-29 | Justin Germano | R | 30 | L 2-8 | @ ARI | 12 | 48 | L | 4.1 | 10 | 7 | 7 | 1 | 1 | 5 | 79 | 25 | 54 | 68% | 2-10 | 6.17 | 1.53 |
| 2012-09-30 | Chris Rusin | L | 26 | W 7-2 | @ ARI | 7 | 7 | W | 5.0 | 3 | 2 | 1 | 0 | 2 | 4 | 68 | 29 | 39 | 57% | 2-3 | 6.30 | 1.63 |
| 2012-10-01 | Jason Berken | R | 29 | W 0-3 | vs HOU | 4 | 28 | L | 4.2 | 4 | 2 | 2 | 1 | 1 | 2 | 60 | 21 | 39 | 65% | 0-3 | 5.40 | 1.80 |
| 2012-10-02 | Chris Volstad | R | 26 | W 0-3 | vs HOU | 21 | 123 | L | 7.0 | 5 | 2 | 1 | 1 | 0 | 6 | 92 | 26 | 66 | 72% | 3-12 | 6.32 | 1.62 |
| 2012-10-03 | Travis Wood | L | 26 | L 5-4 | vs HOU | 26 | 61 | - | 6.1 | 3 | 1 | 1 | 0 | 5 | 4 | 92 | 38 | 54 | 59% | 6-13 | 4.27 | 1.20 |