| 91 | Alfredo Aceves | P | MLB | 6-3 | 200 | Right | Right | 12/8/1982 | 29 | San Luis Rio Colorado,Mexico | 2008 | UDFA | | NYY |
|
| 32 | Matt Albers | P | MLB | 6-0 | 195 | Left | Right | 1/20/1983 | 29 | Sugar Land,Texas | 2001 | 23 | 686 | HOU |
| 26 | Lars Anderson | 1B | MLB | 6-4 | | Left | Left | 9/25/1987 | 24 | Oakland,California | 2006 | 18 | 553 | BOS |
| 48 | Scott Atchison | P | MLB | 6-2 | 180 | Right | Right | 3/29/1976 | 36 | Denton,Texas | 1998 | 49 | 1423 | SEA |
| 3 | Mike Aviles | SS | MLB | 5-9 | 195 | Right | Right | 3/13/1981 | 31 | New York,New York | 2003 | 7 | 192 | KC |
| 40 | Andrew Bailey | P | MLB | 6-3 | 220 | Right | Right | 5/31/1984 | 28 | Haddon Heights,New Jersey | 2006 | 6 | 188 | OAK |
| 51 | Daniel Bard | P | MLB | 6-4 | 185 | Right | Right | 6/25/1985 | 27 | Charlotte,North Carolina | 2006 | 1 | 28 | BOS |
| 54 | Pedro Beato | P | MLB | 6-5 | 210 | Right | Right | 10/27/1986 | 25 | Santo Domingo,Dominican Republic | 2006 | 1 | 32 | BAL |
| 19 | Josh Beckett | P | MLB | 6-4 | 190 | Right | Right | 5/15/1980 | 32 | Spring,Texas | 1999 | 1 | 2 | FLA |
| 64 | Mike Bowden | P | MLB | 6-3 | 215 | Right | Right | 9/9/1986 | 25 | Winfield,Illinois | 2005 | 1 | 47 | BOS |
| 32 | Craig Breslow | P | MLB | 6-1 | 180 | Left | Left | 8/8/1980 | 31 | New Haven,Connecticut | 2002 | 26 | 769 | MIL |
| 11 | Clay Buchholz | P | MLB | 6-3 | 190 | Left | Right | 8/14/1984 | 27 | Lumberton,Texas | 2005 | 1 | 42 | BOS |
| 23 | Marlon Byrd | CF | MLB | 6-0 | 225 | Right | Right | 8/30/1977 | 34 | Boynton Beach,Florida | 1999 | 10 | 306 | PHI |
| 52 | Chris Carpenter | P | MLB | 6-4 | 215 | Right | Right | 12/26/1985 | 26 | Kent,Ohio | 2008 | 3 | 97 | CHC |
| 77 | Pedro Ciriaco | SS-2B | MLB | 6-0 | 150 | Right | Right | 9/27/1985 | 26 | San Pedro de Macoris,Dominican Republic | 2005 | UDFA | | ARI |
| 35 | Aaron Cook | P | MLB | 6-3 | 175 | Right | Right | 2/8/1979 | 33 | Fort Campbell,Kentucky | 1997 | 2 | 70 | COL |
| 13 | Carl Crawford | LF | MLB | 6-2 | 219 | Left | Left | 8/5/1981 | 30 | Houston,Texas | 1999 | 2 | 52 | TB |
| 56 | Ivan DeJesus | 2B | MLB | 5-11 | 176 | Right | Right | 5/1/1987 | 25 | Guaynabo,Puerto Rico | 2005 | 2 | 51 | LAD |
| 61 | Felix Doubront | P | MLB | 6-2 | 166 | Left | Left | 10/23/1987 | 24 | Carabobo,Venezuela | 2006 | UDFA | | BOS |
| 2 | Jacoby Ellsbury | CF | MLB | 6-1 | 185 | Left | Left | 9/11/1983 | 28 | Madras,Oregon | 2005 | 1 | 23 | BOS |
| 47 | Justin Germano | P | MLB | 6-2 | 190 | Right | Right | 8/6/1982 | 29 | Pasadena,California | 2000 | 13 | 379 | SD |
| 50 | Mauro Gomez | 1B | MLB | 6-2 | 190 | Right | Right | 9/7/1984 | 27 | Bani,Dominican Republic | 2003 | UDFA | | TEX |
| 28 | Adrian Gonzalez | 1B | MLB | 6-2 | 190 | Left | Left | 5/8/1982 | 30 | San Diego,California | 2000 | 1 | 1 | FLA |
| 53 | Rich Hill | P | MLB | 6-4 | 180 | Left | Left | 3/11/1980 | 32 | Boston,Massachusetts | 2002 | 4 | 112 | CHC |
| 58 | Jose Iglesias | SS | MLB | 5-11 | 175 | Right | Right | 1/5/1990 | 22 | Havana,Cuba | | UDFA | | |
| 55 | Ryan Kalish | CF | MLB | 6-1 | 205 | Left | Left | 3/28/1988 | 24 | Shrewsburg,New Jersey | 2006 | 9 | 283 | BOS |
| 60 | Ryan Lavarnway | C | MLB | 6-4 | 225 | Right | Right | 8/7/1987 | 24 | Woodland Hills,California | 2008 | 6 | 202 | BOS |
| 31 | Jon Lester | P | MLB | 6-3 | 200 | Left | Left | 1/7/1984 | 28 | Tacoma,Washington | 2002 | 2 | 57 | BOS |
| 23 | Brent Lillibridge | 1B-SS | MLB | 5-11 | 185 | Right | Right | 9/18/1983 | 28 | Everett,Washington | 2005 | 4 | 121 | PIT |
| 67 | Che-Hsuan Lin | CF | MLB | 6-0 | 180 | Right | Right | 9/21/1988 | 23 | Hwa-Lian,Taiwan | 2007 | UDFA | | BOS |
| 22 | James Loney | 1B | MLB | 6-3 | 200 | Left | Left | 5/7/1984 | 28 | Houston,Texas | 2002 | 1 | 19 | LAD |
| 18 | Daisuke Matsuzaka | P | MLB | 6-1 | 187 | Right | Right | 9/13/1980 | 31 | Tokyo,Japan | 2008 | UDFA | | BOS |
| 54 | Darnell McDonald | LF-SS | MLB | 5-11 | 201 | Right | Right | 11/17/1978 | 33 | Fort Collins,Colorado | 1997 | 1 | 26 | BAL |
| 37 | Mark Melancon | P | MLB | 6-1 | 175 | Right | Right | 3/28/1985 | 27 | Wheat Ridge,Colorado | 2006 | 9 | 284 | NYY |
| 64 | Will Middlebrooks | 3B | MLB | 6-3 | 197 | Right | Right | 9/9/1988 | 23 | Greenville,Texas | 2007 | 5 | 174 | BOS |
| 30 | Andrew Miller | P | MLB | 6-6 | 175 | Left | Left | 5/21/1985 | 27 | Gainesville,Florida | 2006 | 1 | 6 | DET |
| 46 | Franklin Morales | P | MLB | 6-0 | 170 | Left | Left | 1/24/1986 | 26 | San Juan Morros,Venezuela | 2002 | UDFA | | COL |
| 59 | Clayton Mortensen | P | MLB | 6-4 | 180 | Right | Right | 4/10/1985 | 27 | Rexburg,Idaho | 2007 | 1 | 36 | STL |
| 66 | Daniel Nava | LF | MLB | 5-10 | 200 | Both | Left | 2/20/1983 | 29 | Redwood City,California | 2008 | UDFA | | BOS |
| 34 | David Ortiz | DH | MLB | 6-4 | 237 | Left | Left | 11/18/1975 | 36 | Santo Domingo,Dominican Republic | 1992 | UDFA | | SEA |
| 44 | Vicente Padilla | P | MLB | 6-2 | 200 | Right | Right | 9/7/1977 | 34 | Chinandoga,Nicaragua | 1998 | UDFA | | ARI |
| 15 | Dustin Pedroia | 2B | MLB | 5-9 | 180 | Right | Right | 8/17/1983 | 28 | Woodland,California | 2004 | 2 | 65 | BOS |
| 26 | Scott Podsednik | LF-CF | MLB | 6-0 | 170 | Left | Left | 3/18/1976 | 36 | West,Texas | 1994 | 3 | 85 | TEX |
| 5 | Nick Punto | 3B-2B | MLB | 5-9 | 170 | Both | Right | 11/8/1977 | 34 | San Diego,California | 1998 | 21 | 614 | PHI |
| 62 | Guillermo Quiroz | C | MLB | 6-1 | 202 | Right | Right | 11/29/1981 | 30 | Maracaibo,Venezuela | 1998 | UDFA | | TOR |
| 16 | Jason Repko | CF-LF | MLB | 5-11 | 185 | Right | Right | 12/27/1980 | 31 | East Chicago,Indiana | 1999 | 1 | 37 | LAD |
| 7 | Cody Ross | RF | MLB | 5-11 | 180 | Right | Left | 12/23/1980 | 31 | Portales,New Mexico | 1999 | 4 | 117 | DET |
| 39 | Jarrod Saltalamacchia | C | MLB | 6-4 | 235 | Both | Right | 5/2/1985 | 27 | West Palm Beach,Florida | 2003 | 1 | 36 | ATL |
| 10 | Kelly Shoppach | C | MLB | 6-0 | 215 | Right | Right | 4/29/1980 | 32 | Fort Worth,Texas | 2001 | 2 | 48 | BOS |
| 71 | Nate Spears | 3B-2B | MLB | 5-11 | 168 | Left | Right | 5/3/1985 | 27 | Fort Myers,Florida | 2003 | 5 | 134 | BAL |
| 47 | Zach Stewart | P | MLB | 6-2 | 205 | Right | Right | 9/28/1986 | 25 | Wichita Falls,Texas | 2008 | 3 | 84 | CIN |
| 12 | Ryan Sweeney | RF | MLB | 6-4 | 200 | Left | Left | 2/20/1985 | 27 | Cedar Rapids,Iowa | 2003 | 2 | 52 | CHW |
| 63 | Junichi Tazawa | P | MLB | 5-11 | 180 | Right | Right | 6/6/1986 | 26 | Yokohama,Japan | 2009 | UDFA | | BOS |
| 50 | Justin Thomas | P | MLB | 6-3 | 220 | Left | Left | 1/18/1984 | 28 | Toledo,Ohio | 2005 | 4 | 113 | SEA |
| 23 | Danny Valencia | 3B | MLB | 6-2 | 200 | Right | Right | 9/19/1984 | 27 | Boca Raton,Florida | 2006 | 19 | 576 | MIN |
| 20 | Kevin Youkilis | 3B | MLB | 6-1 | 220 | Right | Right | 3/15/1979 | 33 | Cincinnati,Ohio | 2001 | 8 | 243 | BOS |