| 2012-04-06 | vs MIN | 1 | W 4-2 | 1-0 | 1 | 46,773 | Jake Arrieta | Carl Pavano | Jake Arrieta | Carl Pavano | Jim Johnson | 4 | 2 | 2 |
| 2012-04-07 | vs MIN | 2 | W 8-2 | 2-0 | 1 | 31,532 | Tommy Hunter | Francisco Liriano | Tommy Hunter | Francisco Liriano | | 12 | 4 | 8 |
| 2012-04-08 | vs MIN | 3 | W 3-1 | 3-0 | 1 | 14,738 | Jason Hammel | Anthony Swarzak | Jason Hammel | Anthony Swarzak | Jim Johnson | 15 | 5 | 10 |
| 2012-04-09 | vs NYA | 4 | L 2-6 | 3-1 | 2 | 25,478 | Brian Matusz | Ivan Nova | Ivan Nova | Brian Matusz | | 17 | 11 | 6 |
| 2012-04-10 | vs NYA | 5 | L 4-5 | 3-2 | 2 | 24,659 | Wei-Yin Chen | Freddy Garcia | Clay Rapada | Pedro Strop | Mariano Rivera | 21 | 16 | 5 |
| 2012-04-11 | vs NYA | 6 | L 4-6 | 3-3 | 3 | 22,919 | Jake Arrieta | CC Sabathia | Rafael Soriano | Kevin Gregg | Mariano Rivera | 25 | 22 | 3 |
| 2012-04-13 | @ TOR | 7 | W 7-5 | 4-3 | 2 | 21,988 | Tommy Hunter | Brandon Morrow | Darren O'Day | Darren Oliver | Jim Johnson | 32 | 27 | 5 |
| 2012-04-14 | @ TOR | 8 | W 6-4 | 5-3 | 2 | 28,355 | Jason Hammel | Henderson Alvarez | Luis Ayala | Francisco Cordero | Jim Johnson | 38 | 31 | 7 |
| 2012-04-15 | @ TOR | 9 | L 2-9 | 5-4 | 2 | 20,252 | Brian Matusz | Kyle Drabek | Kyle Drabek | Brian Matusz | | 40 | 40 | 0 |
| 2012-04-16 | @ CHA | 10 | L 10-4 | 5-5 | 3 | 13,732 | Jake Arrieta | Philip Humber | Pedro Strop | Zach Stewart | | 50 | 44 | 6 |
| 2012-04-17 | @ CHA | 11 | W 3-2 | 6-5 | 3 | 11,267 | Wei-Yin Chen | John Danks | Wei-Yin Chen | John Danks | Jim Johnson | 53 | 46 | 7 |
| 2012-04-18 | @ CHA | 12 | L 1-8 | 6-6 | 3 | 13,818 | Tommy Hunter | Jake Peavy | Jake Peavy | Tommy Hunter | | 54 | 54 | 0 |
| 2012-04-19 | @ CHA | 13 | W 5-3 | 7-6 | 3 | 11,836 | Jason Hammel | Gavin Floyd | Jason Hammel | Gavin Floyd | Jim Johnson | 59 | 57 | 2 |
| 2012-04-20 | @ ANA | 14 | L 3-6 | 7-7 | 3 | 32,272 | Brian Matusz | Jerome Williams | Jerome Williams | Brian Matusz | Jordan Walden | 62 | 63 | -1 |
| 2012-04-21 | @ ANA | 15 | L 3-6 | 7-8 | 3 | 38,054 | Jake Arrieta | Jered Weaver | Jered Weaver | Jake Arrieta | | 65 | 69 | -4 |
| 2012-04-22 | @ ANA | 16 | W 3-2 | 8-8 | 3 | 38,221 | Wei-Yin Chen | Dan Haren | Pedro Strop | LaTroy Hawkins | Jim Johnson | 68 | 71 | -3 |
| 2012-04-24 | vs TOR | 17 | W 2-1 | 9-8 | 3 | 11,058 | Tommy Hunter | Henderson Alvarez | Tommy Hunter | Henderson Alvarez | Pedro Strop | 70 | 72 | -2 |
| 2012-04-25 | vs TOR | 18 | W 3-0 | 10-8 | 3 | 10,415 | Jason Hammel | Kyle Drabek | Jason Hammel | Kyle Drabek | Pedro Strop | 73 | 72 | 1 |
| 2012-04-26 | vs TOR | 19 | W 5-2 | 11-8 | 2 | 13,725 | Brian Matusz | Drew Hutchison | Darren O'Day | Casey Janssen | Luis Ayala | 78 | 74 | 4 |
| 2012-04-27 | vs OAK | 20 | L 2-5 | 11-9 | 2 | 18,297 | Jake Arrieta | Brandon McCarthy | Brandon McCarthy | Jake Arrieta | Grant Balfour | 80 | 79 | 1 |
| 2012-04-28 | vs OAK | 21 | W 10-1 | 12-9 | 2 | 26,926 | Wei-Yin Chen | Tyson Ross | Wei-Yin Chen | Tyson Ross | | 90 | 80 | 10 |
| 2012-04-29 | vs OAK | 22 | W 5-2 | 13-9 | 2 | 31,793 | Tommy Hunter | Bartolo Colon | Pedro Strop | Grant Balfour | | 95 | 82 | 13 |
| 2012-04-30 | @ NYA | 23 | L 1-2 | 13-10 | 2 | 36,890 | Jason Hammel | Hiroki Kuroda | Hiroki Kuroda | Jason Hammel | Mariano Rivera | 96 | 84 | 12 |
| 2012-05-01 | @ NYA | 24 | W 7-1 | 14-10 | 2 | 37,790 | Brian Matusz | Phil Hughes | Brian Matusz | Phil Hughes | | 103 | 85 | 18 |
| 2012-05-02 | @ NYA | 25 | W 5-0 | 15-10 | 2 | 39,360 | Jake Arrieta | Ivan Nova | Jake Arrieta | Ivan Nova | | 108 | 85 | 23 |
| 2012-05-04 | @ BOS | 26 | W 6-4 | 16-10 | 2 | 37,223 | Wei-Yin Chen | Jon Lester | Troy Patton | Franklin Morales | Jim Johnson | 114 | 89 | 25 |
| 2012-05-05 | @ BOS | 27 | W 8-2 | 17-10 | 2 | 37,581 | Jason Hammel | Aaron Cook | Jason Hammel | Aaron Cook | | 122 | 91 | 31 |
| 2012-05-06 | @ BOS | 28 | W 9-6 | 18-10 | 2 | 37,394 | Tommy Hunter | Clay Buchholz | Chris Davis | Darnell McDonald | | 131 | 97 | 34 |
| 2012-05-07 | vs TEX | 29 | W 3-14 | 19-10 | 2 | 11,938 | Brian Matusz | Matt Harrison | Matt Harrison | Brian Matusz | | 134 | 111 | 23 |
| 2012-05-08 | vs TEX | 30 | W 3-10 | 20-10 | 1 | 11,263 | Jake Arrieta | Neftali Feliz | Neftali Feliz | Jake Arrieta | | 137 | 121 | 16 |
| 2012-05-10 | vs TEX | 31 | W 6-5 | 21-11 | 2 | 0 | Wei-Yin Chen | Colby Lewis | Wei-Yin Chen | Colby Lewis | Jim Johnson | 143 | 126 | 17 |
| 2012-05-10 | vs TEX | 32 | L 3-7 | 21-11 | 2 | 19,250 | Tommy Hunter | Derek Holland | Derek Holland | Tommy Hunter | | 146 | 133 | 13 |
| 2012-05-11 | vs TBA | 33 | W 4-3 | 22-11 | 1 | 26,669 | Dana Eveland | Jeremy Hellickson | Darren O'Day | Joel Peralta | Jim Johnson | 150 | 136 | 14 |
| 2012-05-12 | vs TBA | 34 | W 5-3 | 23-11 | 1 | 32,862 | Brian Matusz | Matt Moore | Brian Matusz | Matt Moore | Jim Johnson | 155 | 139 | 16 |
| 2012-05-13 | vs TBA | 35 | L 8-9 | 23-12 | 1 | 29,552 | Jake Arrieta | James Shields | James Shields | Jake Arrieta | Fernando Rodney | 163 | 148 | 15 |
| 2012-05-14 | vs NYA | 36 | L 5-8 | 23-13 | 1 | 16,492 | Jason Hammel | Ivan Nova | David Phelps | Luis Ayala | Rafael Soriano | 168 | 156 | 12 |
| 2012-05-15 | vs NYA | 37 | W 5-2 | 24-13 | 1 | 24,055 | Wei-Yin Chen | CC Sabathia | Wei-Yin Chen | CC Sabathia | Jim Johnson | 173 | 158 | 15 |
| 2012-05-16 | @ KCA | 38 | W 4-3 | 25-13 | 1 | 17,949 | Tommy Hunter | Felipe Paulino | Kevin Gregg | Nathan Adcock | Jim Johnson | 177 | 161 | 16 |
| 2012-05-17 | @ KCA | 39 | W 5-3 | 26-13 | 1 | 31,076 | Brian Matusz | Luke Hochevar | Brian Matusz | Luke Hochevar | Jim Johnson | 182 | 164 | 18 |
| 2012-05-18 | @ WAS | 40 | W 2-1 | 27-13 | 1 | 36,680 | Jake Arrieta | Edwin Jackson | Kevin Gregg | Ryan Mattheus | Pedro Strop | 184 | 165 | 19 |
| 2012-05-19 | @ WAS | 41 | W 6-5 | 28-13 | 1 | 42,331 | Jason Hammel | Ross Detwiler | Jason Hammel | Ross Detwiler | Jim Johnson | 190 | 170 | 20 |
| 2012-05-20 | @ WAS | 42 | L 3-9 | 28-14 | 1 | 41,918 | Wei-Yin Chen | Stephen Strasburg | Stephen Strasburg | Wei-Yin Chen | | 193 | 179 | 14 |
| 2012-05-21 | vs BOS | 43 | L 6-8 | 28-15 | 1 | 16,392 | Tommy Hunter | Clay Buchholz | Andrew Miller | Kevin Gregg | Alfredo Aceves | 199 | 187 | 12 |
| 2012-05-22 | vs BOS | 44 | W 4-1 | 29-15 | 1 | 25,171 | Brian Matusz | Felix Doubront | Brian Matusz | Felix Doubront | Jim Johnson | 203 | 188 | 15 |
| 2012-05-23 | vs BOS | 45 | L 5-6 | 29-16 | 1 | 27,806 | Jake Arrieta | Daniel Bard | Daniel Bard | Jake Arrieta | Alfredo Aceves | 208 | 194 | 14 |
| 2012-05-25 | vs KCA | 46 | W 8-2 | 30-16 | 1 | 28,954 | Jason Hammel | Bruce Chen | Jason Hammel | Bruce Chen | | 216 | 196 | 20 |
| 2012-05-26 | vs KCA | 47 | L 3-4 | 30-17 | 1 | 26,714 | Wei-Yin Chen | Felipe Paulino | Greg Holland | Pedro Strop | Jonathan Broxton | 219 | 200 | 19 |
| 2012-05-27 | vs KCA | 48 | L 2-4 | 30-18 | 1 | 33,919 | Brian Matusz | Luke Hochevar | Tim Collins | Brian Matusz | Jonathan Broxton | 221 | 204 | 17 |
| 2012-05-28 | @ TOR | 49 | L 2-6 | 30-19 | 1 | 16,575 | Tommy Hunter | Drew Hutchison | Drew Hutchison | Tommy Hunter | Casey Janssen | 223 | 210 | 13 |
| 2012-05-29 | @ TOR | 50 | L 6-8 | 30-20 | 1 | 17,352 | Jake Arrieta | Ricky Romero | Ricky Romero | Jake Arrieta | | 229 | 218 | 11 |
| 2012-05-30 | @ TOR | 51 | L 1-4 | 30-21 | 1 | 17,754 | Jason Hammel | Brandon Morrow | Brandon Morrow | Jason Hammel | Casey Janssen | 230 | 222 | 8 |
| 2012-06-01 | @ TBA | 52 | L 0-5 | 30-22 | 2 | 17,224 | Wei-Yin Chen | David Price | David Price | Wei-Yin Chen | Fernando Rodney | 230 | 227 | 3 |
| 2012-06-02 | @ TBA | 53 | W 2-1 | 31-22 | 1 | 21,693 | Brian Matusz | Jeremy Hellickson | Brian Matusz | Jeremy Hellickson | Jim Johnson | 232 | 228 | 4 |
| 2012-06-03 | @ TBA | 54 | L 4-8 | 31-23 | 2 | 21,693 | Jake Arrieta | Matt Moore | Matt Moore | Jake Arrieta | | 236 | 236 | 0 |
| 2012-06-05 | @ BOS | 55 | W 8-6 | 32-23 | 1 | 37,181 | Jason Hammel | Jon Lester | Jim Johnson | Alfredo Aceves | | 244 | 242 | 2 |
| 2012-06-06 | @ BOS | 56 | W 2-1 | 33-23 | 1 | 37,243 | Wei-Yin Chen | Josh Beckett | Wei-Yin Chen | Josh Beckett | Jim Johnson | 246 | 243 | 3 |
| 2012-06-07 | @ BOS | 57 | L 0-7 | 33-24 | 1 | 37,307 | Brian Matusz | Clay Buchholz | Clay Buchholz | Brian Matusz | | 246 | 250 | -4 |
| 2012-06-08 | vs PHI | 58 | L 6-9 | 33-25 | 2 | 40,459 | Jake Arrieta | Joe Blanton | Joe Blanton | Jake Arrieta | Jonathan Papelbon | 252 | 259 | -7 |
| 2012-06-09 | vs PHI | 59 | W 6-4 | 34-25 | 1 | 46,611 | Tommy Hunter | Vance Worley | Luis Ayala | B.J. Rosenberg | | 258 | 263 | -5 |
| 2012-06-10 | vs PHI | 60 | W 5-4 | 35-25 | 1 | 45,267 | Jason Hammel | Cliff Lee | Darren O'Day | Joe Savery | | 263 | 267 | -4 |
| 2012-06-12 | vs PIT | 61 | W 8-6 | 36-25 | 1 | 15,618 | Wei-Yin Chen | Brad Lincoln | Wei-Yin Chen | Brad Lincoln | Jim Johnson | 271 | 273 | -2 |
| 2012-06-13 | vs PIT | 62 | W 7-1 | 37-25 | 1 | 23,238 | Jake Arrieta | Kevin Correia | Jake Arrieta | Kevin Correia | | 278 | 274 | 4 |
| 2012-06-14 | vs PIT | 63 | L 12-6 | 37-26 | 1 | 29,995 | Tommy Hunter | Erik Bedard | Tommy Hunter | Erik Bedard | | 290 | 280 | 10 |
| 2012-06-15 | @ ATL | 64 | L 2-4 | 37-27 | 1 | 30,384 | Brian Matusz | Tommy Hanson | Chad Durbin | Brian Matusz | Craig Kimbrel | 292 | 284 | 8 |
| 2012-06-16 | @ ATL | 65 | W 5-0 | 38-27 | 1 | 41,131 | Jason Hammel | Brandon Beachy | Jason Hammel | Brandon Beachy | | 297 | 284 | 13 |
| 2012-06-17 | @ ATL | 66 | W 2-0 | 39-27 | 1 | 29,530 | Wei-Yin Chen | Randall Delgado | Wei-Yin Chen | Randall Delgado | Jim Johnson | 299 | 284 | 15 |
| 2012-06-18 | @ NYN | 67 | L 0-5 | 39-28 | 1 | 29,014 | Jake Arrieta | R.A. Dickey | R.A. Dickey | Jake Arrieta | | 299 | 289 | 10 |
| 2012-06-19 | @ NYN | 68 | L 0-5 | 39-29 | 2 | 32,587 | Tommy Hunter | Johan Santana | Johan Santana | Tommy Hunter | | 299 | 294 | 5 |
| 2012-06-20 | @ NYN | 69 | L 3-4 | 39-30 | 3 | 29,855 | Brian Matusz | Dillon Gee | Dillon Gee | Brian Matusz | Frank Francisco | 302 | 298 | 4 |
| 2012-06-22 | vs WAS | 70 | W 2-1 | 40-30 | 1 | 45,891 | Jason Hammel | Jordan Zimmermann | Jason Hammel | Jordan Zimmermann | Jim Johnson | 304 | 299 | 5 |
| 2012-06-23 | vs WAS | 71 | L 1-3 | 40-31 | 2 | 46,298 | Wei-Yin Chen | Edwin Jackson | Edwin Jackson | Wei-Yin Chen | Tyler Clippard | 305 | 302 | 3 |
| 2012-06-24 | vs WAS | 72 | W 2-1 | 41-31 | 2 | 41,794 | Jake Arrieta | Ross Detwiler | Pedro Strop | Sean Burnett | Jim Johnson | 307 | 303 | 4 |
| 2012-06-26 | vs ANA | 73 | L 3-7 | 41-32 | 2 | 24,296 | Brian Matusz | C.J. Wilson | C.J. Wilson | Brian Matusz | | 310 | 310 | 0 |
| 2012-06-27 | vs ANA | 74 | L 1-13 | 41-33 | 2 | 18,055 | Jason Hammel | Jered Weaver | Jered Weaver | Jason Hammel | | 311 | 323 | -12 |
| 2012-06-28 | vs CLE | 75 | L 2-7 | 41-34 | 2 | 17,676 | Wei-Yin Chen | Zach McAllister | Zach McAllister | Wei-Yin Chen | | 313 | 330 | -17 |
| 2012-06-29 | vs CLE | 76 | W 9-8 | 42-34 | 2 | 24,779 | Jake Arrieta | Derek Lowe | Matt Lindstrom | Joe Smith | Jim Johnson | 322 | 338 | -16 |
| 2012-06-30 | vs CLE | 77 | W 5-11 | 43-34 | 2 | 35,335 | Dana Eveland | Josh Tomlin | Josh Tomlin | Dana Eveland | | 327 | 349 | -22 |
| 2012-07-01 | vs CLE | 78 | L 2-6 | 43-35 | 2 | 16,689 | Brian Matusz | Justin Masterson | Justin Masterson | Brian Matusz | | 329 | 355 | -26 |
| 2012-07-02 | @ SEA | 79 | L 3-6 | 43-36 | 2 | 14,805 | Jason Hammel | Hisashi Iwakuma | Steve Delabar | Jason Hammel | Tom Wilhelmsen | 332 | 361 | -29 |
| 2012-07-03 | @ SEA | 80 | W 5-4 | 44-36 | 2 | 16,270 | Wei-Yin Chen | Felix Hernandez | Darren O'Day | Charlie Furbush | Jim Johnson | 337 | 365 | -28 |
| 2012-07-04 | @ SEA | 81 | W 4-2 | 45-36 | 2 | 21,982 | Chris Tillman | Hector Noesi | Chris Tillman | Hector Noesi | Jim Johnson | 341 | 367 | -26 |
| 2012-07-05 | @ ANA | 82 | L 7-9 | 45-37 | 2 | 38,104 | Jake Arrieta | Garrett Richards | LaTroy Hawkins | Luis Ayala | Ernesto Frieri | 348 | 376 | -28 |
| 2012-07-06 | @ ANA | 83 | W 3-2 | 46-37 | 2 | 42,716 | Miguel Gonzalez | C.J. Wilson | Miguel Gonzalez | C.J. Wilson | Jim Johnson | 351 | 378 | -27 |
| 2012-07-07 | @ ANA | 84 | L 0-3 | 46-38 | 3 | 41,147 | Jason Hammel | Jered Weaver | Jered Weaver | Jason Hammel | Scott Downs | 351 | 381 | -30 |
| 2012-07-08 | @ ANA | 85 | L 0-6 | 46-39 | 2 | 37,108 | Wei-Yin Chen | Brad Mills | Brad Mills | Wei-Yin Chen | | 351 | 387 | -36 |
| 2012-07-13 | vs DET | 86 | L 2-7 | 46-40 | 2 | 35,566 | Jason Hammel | Doug Fister | Doug Fister | Jason Hammel | | 353 | 394 | -41 |
| 2012-07-14 | vs DET | 87 | W 8-6 | 47-40 | 2 | 43,215 | Wei-Yin Chen | Max Scherzer | Kevin Gregg | Joaquin Benoit | | 361 | 400 | -39 |
| 2012-07-15 | vs DET | 88 | L 0-4 | 47-41 | 2 | 30,439 | Miguel Gonzalez | Justin Verlander | Justin Verlander | Miguel Gonzalez | | 361 | 404 | -43 |
| 2012-07-16 | @ MIN | 89 | W 7-19 | 48-41 | 2 | 32,445 | Chris Tillman | Scott Diamond | Scott Diamond | Chris Tillman | | 368 | 423 | -55 |
| 2012-07-17 | @ MIN | 90 | L 4-6 | 48-42 | 2 | 32,202 | Zachary Britton | Samuel Deduno | Alex Burnett | Luis Ayala | Jared Burton | 372 | 429 | -57 |
| 2012-07-18 | @ MIN | 91 | W 2-1 | 49-42 | 2 | 33,195 | Tommy Hunter | Francisco Liriano | Tommy Hunter | Francisco Liriano | Jim Johnson | 374 | 430 | -56 |
| 2012-07-19 | @ MIN | 92 | W 4-3 | 50-42 | 2 | 37,676 | Wei-Yin Chen | Cole De Vries | Wei-Yin Chen | Alex Burnett | Jim Johnson | 378 | 433 | -55 |
| 2012-07-20 | @ CLE | 93 | L 10-2 | 50-43 | 2 | 33,954 | Miguel Gonzalez | Derek Lowe | Miguel Gonzalez | Derek Lowe | | 388 | 435 | -47 |
| 2012-07-21 | @ CLE | 94 | W 3-1 | 51-43 | 2 | 36,247 | Chris Tillman | Zach McAllister | Chris Tillman | Zach McAllister | Jim Johnson | 391 | 436 | -45 |
| 2012-07-22 | @ CLE | 95 | W 4-3 | 52-43 | 2 | 28,049 | Zachary Britton | Josh Tomlin | Zachary Britton | Josh Tomlin | Jim Johnson | 395 | 439 | -44 |
| 2012-07-23 | @ CLE | 96 | L 1-3 | 52-44 | 2 | 18,264 | Tommy Hunter | Justin Masterson | Justin Masterson | Tommy Hunter | Chris Perez | 396 | 442 | -46 |
| 2012-07-24 | vs TBA | 97 | L 1-3 | 52-45 | 2 | 17,592 | Wei-Yin Chen | Jeremy Hellickson | Jeremy Hellickson | Wei-Yin Chen | Fernando Rodney | 397 | 445 | -48 |
| 2012-07-25 | vs TBA | 98 | L 1-10 | 52-46 | 2 | 19,582 | Miguel Gonzalez | David Price | David Price | Miguel Gonzalez | | 398 | 455 | -57 |
| 2012-07-26 | vs TBA | 99 | W 6-2 | 53-46 | 2 | 21,301 | Chris Tillman | James Shields | Chris Tillman | James Shields | | 404 | 457 | -53 |
| 2012-07-27 | vs OAK | 100 | W 9-14 | 54-46 | 2 | 29,278 | Zachary Britton | Jarrod Parker | Jerry Blevins | Jim Johnson | | 413 | 471 | -58 |
| 2012-07-28 | vs OAK | 101 | L 1-6 | 54-47 | 2 | 21,143 | Tommy Hunter | Bartolo Colon | Bartolo Colon | Tommy Hunter | | 414 | 477 | -63 |
| 2012-07-29 | vs OAK | 102 | W 6-1 | 55-47 | 2 | 19,698 | Wei-Yin Chen | Travis Blackley | Wei-Yin Chen | Travis Blackley | | 420 | 478 | -58 |
| 2012-07-30 | @ NYA | 103 | W 5-4 | 56-47 | 2 | 43,052 | Miguel Gonzalez | Freddy Garcia | Miguel Gonzalez | Freddy Garcia | Jim Johnson | 425 | 482 | -57 |
| 2012-07-31 | @ NYA | 104 | L 11-5 | 56-48 | 2 | 42,821 | Chris Tillman | Ivan Nova | Chris Tillman | Ivan Nova | | 436 | 487 | -51 |
| 2012-08-01 | @ NYA | 105 | W 3-12 | 57-48 | 2 | 44,593 | Zachary Britton | Phil Hughes | Phil Hughes | Zachary Britton | | 439 | 499 | -60 |
| 2012-08-03 | @ TBA | 106 | L 0-2 | 57-49 | 2 | 18,410 | Tommy Hunter | Matt Moore | Matt Moore | Tommy Hunter | Fernando Rodney | 439 | 501 | -62 |
| 2012-08-04 | @ TBA | 107 | W 4-0 | 58-49 | 2 | 20,612 | Wei-Yin Chen | Jeremy Hellickson | Wei-Yin Chen | Jeremy Hellickson | | 443 | 501 | -58 |
| 2012-08-05 | @ TBA | 108 | W 1-0 | 59-49 | 2 | 29,530 | Miguel Gonzalez | David Price | Luis Ayala | Joel Peralta | Jim Johnson | 444 | 501 | -57 |
| 2012-08-06 | vs SEA | 109 | W 3-1 | 60-49 | 2 | 21,184 | Chris Tillman | Jason Vargas | Chris Tillman | Jason Vargas | Jim Johnson | 447 | 502 | -55 |
| 2012-08-07 | vs SEA | 110 | W 8-7 | 61-49 | 2 | 15,433 | Zachary Britton | Blake Beavan | Darren O'Day | Shawn Kelley | | 455 | 509 | -54 |
| 2012-08-08 | vs SEA | 111 | W 9-2 | 62-49 | 1 | 17,312 | Steve Johnson | Kevin Millwood | Steve Johnson | Kevin Millwood | | 464 | 511 | -47 |
| 2012-08-09 | vs KCA | 112 | L 2-8 | 62-50 | 2 | 21,226 | Wei-Yin Chen | Will Smith | Will Smith | Wei-Yin Chen | | 466 | 519 | -53 |
| 2012-08-10 | vs KCA | 113 | W 7-1 | 63-50 | 1 | 17,277 | Miguel Gonzalez | Luke Hochevar | Miguel Gonzalez | Luke Hochevar | | 473 | 520 | -47 |
| 2012-08-11 | vs KCA | 114 | L 3-7 | 63-51 | 2 | 40,456 | Chris Tillman | Luis Mendoza | Luis Mendoza | Chris Tillman | | 476 | 527 | -51 |
| 2012-08-12 | vs KCA | 115 | W 5-3 | 64-51 | 2 | 20,935 | Tommy Hunter | Bruce Chen | Luis Ayala | Bruce Chen | Jim Johnson | 481 | 530 | -49 |
| 2012-08-14 | vs BOS | 116 | W 7-1 | 65-51 | 2 | 26,204 | Wei-Yin Chen | Josh Beckett | Wei-Yin Chen | Josh Beckett | | 488 | 531 | -43 |
| 2012-08-15 | vs BOS | 117 | W 5-3 | 66-51 | 2 | 22,269 | Miguel Gonzalez | Aaron Cook | Miguel Gonzalez | Aaron Cook | Jim Johnson | 493 | 534 | -41 |
| 2012-08-16 | vs BOS | 118 | L 3-6 | 66-52 | 2 | 25,483 | Chris Tillman | Clay Buchholz | Clay Buchholz | Luis Ayala | Alfredo Aceves | 496 | 540 | -44 |
| 2012-08-17 | @ DET | 119 | L 3-5 | 66-53 | 2 | 41,620 | Tommy Hunter | Justin Verlander | Joaquin Benoit | Darren O'Day | Jose Valverde | 499 | 545 | -46 |
| 2012-08-18 | @ DET | 120 | W 3-2 | 67-53 | 2 | 42,132 | Zachary Britton | Rick Porcello | Zachary Britton | Rick Porcello | Jim Johnson | 502 | 547 | -45 |
| 2012-08-19 | @ DET | 121 | W 7-5 | 68-53 | 2 | 40,511 | Wei-Yin Chen | Doug Fister | Wei-Yin Chen | Doug Fister | Jim Johnson | 509 | 552 | -43 |
| 2012-08-20 | @ TEX | 122 | L 1-5 | 68-54 | 2 | 36,257 | Miguel Gonzalez | Ryan Dempster | Ryan Dempster | Miguel Gonzalez | | 510 | 557 | -47 |
| 2012-08-21 | @ TEX | 123 | W 5-3 | 69-54 | 2 | 32,146 | Chris Tillman | Scott Feldman | Chris Tillman | Scott Feldman | Jim Johnson | 515 | 560 | -45 |
| 2012-08-22 | @ TEX | 124 | W 3-12 | 70-54 | 1 | 40,714 | Tommy Hunter | Derek Holland | Derek Holland | Tommy Hunter | | 518 | 572 | -54 |
| 2012-08-24 | vs TOR | 125 | W 6-4 | 71-54 | 1 | 25,754 | Zachary Britton | Carlos Villanueva | Zachary Britton | Carlos Villanueva | Jim Johnson | 524 | 576 | -52 |
| 2012-08-25 | vs TOR | 126 | W 8-2 | 72-54 | 1 | 25,082 | Steve Johnson | Brandon Morrow | Steve Johnson | Brandon Morrow | | 532 | 578 | -46 |
| 2012-08-27 | vs CHA | 127 | W 4-3 | 73-54 | 1 | 10,955 | Wei-Yin Chen | Francisco Liriano | Pedro Strop | Brett Myers | Jim Johnson | 536 | 581 | -45 |
| 2012-08-28 | vs CHA | 128 | W 6-0 | 74-54 | 1 | 12,841 | Chris Tillman | Chris Sale | Chris Tillman | Chris Sale | | 542 | 581 | -39 |
| 2012-08-29 | vs CHA | 129 | L 1-8 | 74-55 | 1 | 13,098 | Joe Saunders | Dylan Axelrod | Dylan Axelrod | Joe Saunders | | 543 | 589 | -46 |
| 2012-08-30 | vs CHA | 130 | W 5-3 | 75-55 | 1 | 10,141 | Zachary Britton | Jose Quintana | Zachary Britton | Jose Quintana | Jim Johnson | 548 | 592 | -44 |
| 2012-08-31 | @ NYA | 131 | W 6-1 | 76-55 | 1 | 43,352 | Miguel Gonzalez | Hiroki Kuroda | Miguel Gonzalez | Hiroki Kuroda | | 554 | 593 | -39 |
| 2012-09-01 | @ NYA | 132 | L 3-4 | 76-56 | 1 | 46,122 | Wei-Yin Chen | David Phelps | Boone Logan | Wei-Yin Chen | Rafael Soriano | 557 | 597 | -40 |
| 2012-09-02 | @ NYA | 133 | W 8-3 | 77-56 | 1 | 46,501 | Chris Tillman | Phil Hughes | Randy Wolf | Phil Hughes | | 565 | 600 | -35 |
| 2012-09-03 | @ TOR | 134 | W 4-0 | 78-56 | 1 | 17,220 | Joe Saunders | J.A. Happ | Joe Saunders | J.A. Happ | | 569 | 600 | -31 |
| 2012-09-04 | @ TOR | 135 | W 12-0 | 79-56 | 1 | 13,556 | Zachary Britton | Carlos Villanueva | Zachary Britton | Carlos Villanueva | | 581 | 600 | -19 |
| 2012-09-05 | @ TOR | 136 | L 4-6 | 79-57 | 1 | 14,458 | Miguel Gonzalez | Brandon Morrow | Steve Delabar | Miguel Gonzalez | | 585 | 606 | -21 |
| 2012-09-06 | vs NYA | 137 | L 10-6 | 79-58 | 1 | 46,298 | Jason Hammel | David Phelps | Darren O'Day | David Robertson | | 595 | 612 | -17 |
| 2012-09-07 | vs NYA | 138 | L 5-8 | 79-59 | 1 | 40,861 | Wei-Yin Chen | Phil Hughes | Phil Hughes | Wei-Yin Chen | | 600 | 620 | -20 |
| 2012-09-08 | vs NYA | 139 | W 5-4 | 80-59 | 1 | 46,067 | Joe Saunders | CC Sabathia | Joe Saunders | CC Sabathia | Jim Johnson | 605 | 624 | -19 |
| 2012-09-09 | vs NYA | 140 | W 3-13 | 81-59 | 1 | 40,346 | Zachary Britton | Freddy Garcia | Joba Chamberlain | Zachary Britton | | 608 | 637 | -29 |
| 2012-09-11 | vs TBA | 141 | W 9-2 | 82-59 | 1 | 23,828 | Jason Hammel | Matt Moore | Steve Johnson | Matt Moore | | 617 | 639 | -22 |
| 2012-09-12 | vs TBA | 142 | W 3-2 | 83-59 | 1 | 26,076 | Miguel Gonzalez | Alex Cobb | Jim Johnson | Kyle Farnsworth | | 620 | 641 | -21 |
| 2012-09-13 | vs TBA | 143 | W 3-2 | 84-59 | 1 | 25,130 | Wei-Yin Chen | Jeremy Hellickson | Randy Wolf | Chris Archer | | 623 | 643 | -20 |
| 2012-09-14 | @ OAK | 144 | L 2-3 | 84-60 | 1 | 35,067 | Joe Saunders | Tom Milone | Tom Milone | Joe Saunders | Grant Balfour | 625 | 646 | -21 |
| 2012-09-15 | @ OAK | 145 | L 2-5 | 84-61 | 1 | 20,342 | Zachary Britton | Jarrod Parker | Jarrod Parker | Zachary Britton | Grant Balfour | 627 | 651 | -24 |
| 2012-09-16 | @ OAK | 146 | W 9-5 | 85-61 | 1 | 20,539 | Randy Wolf | Dan Straily | Brian Matusz | Dan Straily | Jim Johnson | 636 | 656 | -20 |
| 2012-09-17 | @ SEA | 147 | L 10-4 | 85-62 | 1 | 13,036 | Chris Tillman | Hector Noesi | Chris Tillman | Hector Noesi | | 646 | 660 | -14 |
| 2012-09-18 | @ SEA | 148 | W 4-2 | 86-62 | 1 | 12,608 | Wei-Yin Chen | Erasmo Ramirez | Tommy Hunter | Lucas Luetge | Jim Johnson | 650 | 662 | -12 |
| 2012-09-19 | @ SEA | 149 | W 3-1 | 87-62 | 1 | 14,001 | Joe Saunders | Felix Hernandez | Luis Ayala | Josh Kinney | Jim Johnson | 653 | 663 | -10 |
| 2012-09-21 | @ BOS | 150 | W 4-2 | 88-62 | 1 | 37,731 | Miguel Gonzalez | Jon Lester | Miguel Gonzalez | Jon Lester | Jim Johnson | 657 | 665 | -8 |
| 2012-09-22 | @ BOS | 151 | W 9-6 | 89-62 | 1 | 37,570 | Randy Wolf | Aaron Cook | Tommy Hunter | Alfredo Aceves | Jim Johnson | 666 | 671 | -5 |
| 2012-09-23 | @ BOS | 152 | L 1-2 | 89-63 | 1 | 37,310 | Chris Tillman | Felix Doubront | Junichi Tazawa | Luis Ayala | Andrew Bailey | 667 | 673 | -6 |
| 2012-09-24 | vs TOR | 153 | W 4-1 | 90-64 | 2 | 0 | Steve Johnson | Henderson Alvarez | Steve Johnson | Henderson Alvarez | Jim Johnson | 671 | 674 | -3 |
| 2012-09-24 | vs TOR | 154 | L 5-9 | 90-64 | 2 | 31,015 | Wei-Yin Chen | Ricky Romero | Ricky Romero | Wei-Yin Chen | | 676 | 683 | -7 |
| 2012-09-25 | vs TOR | 155 | L 0-4 | 90-65 | 1 | 30,205 | Joe Saunders | Aaron Laffey | Aaron Laffey | Joe Saunders | | 676 | 687 | -11 |
| 2012-09-26 | vs TOR | 156 | L 12-2 | 90-66 | 1 | 26,513 | Miguel Gonzalez | Carlos Villanueva | Miguel Gonzalez | Carlos Villanueva | | 688 | 689 | -1 |
| 2012-09-28 | vs BOS | 157 | W 9-1 | 91-66 | 1 | 33,518 | Chris Tillman | Aaron Cook | Chris Tillman | Aaron Cook | | 697 | 690 | 7 |
| 2012-09-29 | vs BOS | 158 | W 4-3 | 92-66 | 1 | 46,311 | Steve Johnson | Felix Doubront | Tommy Hunter | Felix Doubront | Jim Johnson | 701 | 693 | 8 |
| 2012-09-30 | vs BOS | 159 | W 6-3 | 93-66 | 1 | 41,257 | Joe Saunders | Zach Stewart | Joe Saunders | Zach Stewart | Jim Johnson | 707 | 696 | 11 |
| 2012-10-01 | @ TBA | 160 | L 3-5 | 93-67 | 1 | 13,666 | Wei-Yin Chen | Alex Cobb | Alex Cobb | Wei-Yin Chen | Fernando Rodney | 710 | 701 | 9 |
| 2012-10-02 | @ TBA | 161 | W 1-0 | 94-67 | 1 | 13,460 | Miguel Gonzalez | James Shields | Miguel Gonzalez | James Shields | Jim Johnson | 711 | 701 | 10 |
| 2012-10-03 | @ TBA | 162 | L 1-4 | 94-68 | 1 | 17,909 | Chris Tillman | Jeremy Hellickson | Jeremy Hellickson | Chris Tillman | Fernando Rodney | 712 | 705 | 7 |