| East | W | L | Pct | GB |
| NY Yankees | 95 | 67 | .586 | -- |
| Baltimore | 93 | 69 | .574 | 2.0 |
| Tampa Bay | 90 | 72 | .556 | 5.0 |
| Toronto | 73 | 89 | .451 | 22.0 |
| Boston | 69 | 93 | .426 | 26.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-06 | James Shields | R | 30 | L 7-6 | vs NYA | 1 | 185 | - | 5.0 | 9 | 6 | 6 | 1 | 3 | 3 | 104 | 38 | 66 | 63% | 0-0 | 10.80 | 2.40 |
| 2012-04-07 | David Price | L | 27 | L 8-6 | vs NYA | 1 | 90 | W | 6.1 | 5 | 2 | 2 | 0 | 4 | 5 | 107 | 47 | 60 | 56% | 1-0 | 3.00 | 1.50 |
| 2012-04-08 | Jeremy Hellickson | R | 25 | L 3-0 | vs NYA | 1 | 34 | W | 8.2 | 3 | 0 | 0 | 0 | 4 | 4 | 118 | 52 | 66 | 56% | 1-0 | 0.00 | 0.78 |
| 2012-04-10 | Matt Moore | L | 23 | L 2-5 | @ DET | 1 | 2 | - | 6.2 | 4 | 2 | 2 | 1 | 5 | 4 | 109 | 49 | 60 | 55% | 0-0 | 2.57 | 1.29 |
| 2012-04-11 | James Shields | R | 30 | W 4-2 | @ DET | 2 | 186 | W | 8.0 | 6 | 2 | 2 | 0 | 1 | 5 | 105 | 38 | 67 | 64% | 1-0 | 5.54 | 1.46 |
| 2012-04-12 | Jeff Niemann | R | 29 | L 2-7 | @ DET | 1 | 85 | L | 5.0 | 4 | 3 | 3 | 0 | 2 | 6 | 101 | 44 | 57 | 56% | 0-1 | 5.40 | 1.20 |
| 2012-04-13 | David Price | L | 27 | L 2-12 | @ BOS | 2 | 91 | L | 3.0 | 4 | 3 | 3 | 0 | 3 | 3 | 82 | 36 | 46 | 56% | 1-1 | 5.00 | 1.78 |
| 2012-04-14 | Jeremy Hellickson | R | 25 | L 5-13 | @ BOS | 2 | 35 | - | 5.0 | 7 | 5 | 5 | 3 | 3 | 1 | 101 | 42 | 59 | 58% | 1-0 | 3.21 | 1.21 |
| 2012-04-15 | Matt Moore | L | 23 | L 4-6 | @ BOS | 2 | 3 | L | 6.1 | 8 | 6 | 6 | 2 | 4 | 5 | 109 | 43 | 66 | 61% | 0-1 | 5.54 | 1.62 |
| 2012-04-16 | James Shields | R | 30 | W 1-0 | @ BOS | 3 | 187 | W | 8.1 | 4 | 0 | 0 | 0 | 2 | 5 | 116 | 40 | 76 | 66% | 2-0 | 3.43 | 1.19 |
| 2012-04-17 | Jeff Niemann | R | 29 | L 3-7 | @ TOR | 2 | 86 | L | 5.0 | 3 | 5 | 2 | 2 | 1 | 5 | 91 | 40 | 51 | 56% | 0-2 | 4.50 | 1.00 |
| 2012-04-18 | David Price | L | 27 | W 12-2 | @ TOR | 3 | 92 | W | 5.2 | 8 | 2 | 2 | 1 | 2 | 3 | 105 | 35 | 70 | 67% | 2-1 | 4.20 | 1.73 |
| 2012-04-19 | Jeremy Hellickson | R | 25 | W 9-4 | @ TOR | 3 | 36 | W | 5.2 | 6 | 3 | 2 | 0 | 3 | 4 | 109 | 42 | 67 | 61% | 2-0 | 3.32 | 1.37 |
| 2012-04-20 | Matt Moore | L | 23 | W 4-5 | vs MIN | 3 | 4 | - | 6.1 | 8 | 3 | 3 | 0 | 3 | 2 | 105 | 46 | 59 | 56% | 0-1 | 5.21 | 1.68 |
| 2012-04-21 | James Shields | R | 30 | L 4-1 | vs MIN | 4 | 188 | W | 8.0 | 5 | 1 | 1 | 0 | 2 | 7 | 119 | 44 | 75 | 63% | 3-0 | 2.79 | 1.10 |
| 2012-04-22 | Jeff Niemann | R | 29 | L 6-2 | vs MIN | 3 | 87 | W | 5.1 | 3 | 2 | 2 | 0 | 2 | 5 | 78 | 33 | 45 | 58% | 1-2 | 4.20 | 1.00 |
| 2012-04-24 | David Price | L | 27 | L 5-0 | vs ANA | 4 | 93 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 6 | 119 | 39 | 80 | 67% | 3-1 | 2.63 | 1.33 |
| 2012-04-25 | Jeremy Hellickson | R | 25 | L 3-2 | vs ANA | 4 | 37 | W | 6.0 | 5 | 1 | 1 | 1 | 2 | 5 | 99 | 38 | 61 | 62% | 3-0 | 2.88 | 1.32 |
| 2012-04-26 | Matt Moore | L | 23 | L 4-3 | vs ANA | 4 | 5 | - | 5.2 | 5 | 3 | 2 | 1 | 2 | 6 | 97 | 28 | 69 | 71% | 0-1 | 4.68 | 1.56 |
| 2012-04-27 | James Shields | R | 30 | W 8-4 | @ TEX | 5 | 189 | W | 6.0 | 11 | 4 | 4 | 2 | 0 | 8 | 113 | 40 | 73 | 65% | 4-0 | 3.34 | 1.23 |
| 2012-04-28 | Jeff Niemann | R | 29 | L 2-7 | @ TEX | 4 | 88 | L | 5.2 | 5 | 3 | 2 | 0 | 3 | 4 | 108 | 41 | 67 | 62% | 1-3 | 3.86 | 1.10 |
| 2012-04-29 | David Price | L | 27 | W 5-2 | @ TEX | 5 | 94 | W | 6.1 | 6 | 2 | 2 | 0 | 1 | 6 | 118 | 38 | 80 | 68% | 4-1 | 2.70 | 1.30 |
| 2012-04-30 | Jeremy Hellickson | R | 25 | L 3-2 | vs SEA | 5 | 38 | - | 7.0 | 6 | 1 | 1 | 1 | 0 | 7 | 97 | 29 | 68 | 70% | 3-0 | 2.53 | 1.22 |
| 2012-05-01 | Matt Moore | L | 23 | L 3-1 | vs SEA | 5 | 6 | W | 5.0 | 7 | 1 | 1 | 1 | 1 | 7 | 99 | 35 | 64 | 65% | 1-1 | 4.20 | 1.57 |
| 2012-05-02 | James Shields | R | 30 | L 5-4 | vs SEA | 6 | 190 | W | 6.0 | 4 | 4 | 1 | 2 | 4 | 11 | 115 | 46 | 69 | 60% | 5-0 | 3.07 | 1.24 |
| 2012-05-03 | Jeff Niemann | R | 29 | L 4-3 | vs SEA | 5 | 89 | W | 5.2 | 7 | 3 | 3 | 0 | 2 | 5 | 105 | 42 | 63 | 60% | 2-3 | 4.00 | 1.19 |
| 2012-05-04 | David Price | L | 27 | L 7-2 | vs OAK | 6 | 95 | W | 8.0 | 3 | 1 | 1 | 0 | 1 | 12 | 105 | 31 | 74 | 70% | 5-1 | 2.37 | 1.13 |
| 2012-05-05 | Jeremy Hellickson | R | 25 | W 3-4 | vs OAK | 6 | 39 | - | 3.2 | 5 | 3 | 2 | 1 | 3 | 2 | 102 | 43 | 59 | 58% | 3-0 | 2.75 | 1.31 |
| 2012-05-06 | Matt Moore | L | 23 | W 5-9 | vs OAK | 6 | 7 | L | 4.2 | 7 | 8 | 8 | 1 | 3 | 4 | 105 | 43 | 62 | 59% | 1-2 | 5.66 | 1.63 |
| 2012-05-08 | James Shields | R | 30 | L 3-5 | @ NYA | 7 | 191 | L | 6.0 | 4 | 3 | 3 | 2 | 3 | 4 | 114 | 43 | 71 | 62% | 5-1 | 3.26 | 1.23 |
| 2012-05-09 | Jeff Niemann | R | 29 | W 4-1 | @ NYA | 6 | 90 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 5 | 101 | 33 | 68 | 67% | 2-3 | 3.44 | 1.15 |
| 2012-05-10 | David Price | L | 27 | L 3-5 | @ NYA | 7 | 96 | L | 7.0 | 11 | 5 | 5 | 2 | 3 | 4 | 112 | 40 | 72 | 64% | 5-2 | 3.00 | 1.27 |
| 2012-05-11 | Jeremy Hellickson | R | 25 | L 3-4 | @ BAL | 7 | 40 | - | 6.2 | 5 | 3 | 3 | 2 | 1 | 6 | 98 | 35 | 63 | 64% | 3-0 | 2.93 | 1.23 |
| 2012-05-12 | Matt Moore | L | 23 | L 3-5 | @ BAL | 7 | 8 | L | 4.1 | 4 | 4 | 1 | 0 | 4 | 6 | 105 | 48 | 57 | 54% | 1-3 | 5.31 | 1.67 |
| 2012-05-13 | James Shields | R | 30 | W 9-8 | @ BAL | 8 | 192 | W | 6.1 | 7 | 6 | 4 | 1 | 2 | 5 | 103 | 37 | 66 | 64% | 6-1 | 3.50 | 1.24 |
| 2012-05-14 | Jeff Niemann | R | 29 | W 7-1 | @ TOR | 7 | 91 | - | 1.0 | 1 | 0 | 0 | 0 | 1 | 0 | 29 | 14 | 15 | 52% | 2-3 | 3.34 | 1.17 |
| 2012-05-15 | David Price | L | 27 | W 4-3 | @ TOR | 8 | 97 | W | 7.0 | 6 | 3 | 3 | 1 | 0 | 6 | 117 | 47 | 70 | 60% | 6-2 | 3.12 | 1.21 |
| 2012-05-16 | Jeremy Hellickson | R | 25 | L 2-1 | vs BOS | 8 | 41 | W | 6.0 | 5 | 1 | 1 | 0 | 2 | 6 | 103 | 38 | 65 | 63% | 4-0 | 2.76 | 1.22 |
| 2012-05-17 | Matt Moore | L | 23 | W 3-5 | vs BOS | 8 | 9 | L | 6.0 | 5 | 3 | 3 | 2 | 1 | 8 | 106 | 39 | 67 | 63% | 1-4 | 5.20 | 1.58 |
| 2012-05-18 | James Shields | R | 30 | W 3-5 | vs ATL | 9 | 193 | L | 6.0 | 7 | 4 | 4 | 0 | 3 | 8 | 115 | 43 | 72 | 63% | 6-2 | 3.75 | 1.28 |
| 2012-05-19 | Alex Cobb | R | 25 | L 5-2 | vs ATL | 1 | 10 | W | 7.0 | 6 | 2 | 2 | 0 | 2 | 6 | 112 | 42 | 70 | 63% | 1-0 | 2.57 | 1.14 |
| 2012-05-20 | David Price | L | 27 | W 0-2 | vs ATL | 9 | 98 | L | 7.0 | 6 | 2 | 1 | 1 | 3 | 7 | 122 | 42 | 80 | 66% | 6-3 | 2.90 | 1.22 |
| 2012-05-21 | Jeremy Hellickson | R | 25 | W 2-6 | vs TOR | 9 | 42 | L | 7.1 | 8 | 5 | 2 | 1 | 1 | 3 | 106 | 38 | 68 | 64% | 4-1 | 2.73 | 1.23 |
| 2012-05-22 | Matt Moore | L | 23 | L 8-5 | vs TOR | 9 | 10 | - | 4.2 | 3 | 4 | 2 | 0 | 4 | 6 | 96 | 37 | 59 | 61% | 1-4 | 5.04 | 1.56 |
| 2012-05-23 | James Shields | R | 30 | L 5-4 | vs TOR | 10 | 194 | - | 7.1 | 7 | 3 | 2 | 1 | 1 | 10 | 110 | 29 | 81 | 74% | 6-2 | 3.63 | 1.27 |
| 2012-05-25 | Alex Cobb | R | 25 | W 7-4 | @ BOS | 2 | 11 | W | 5.0 | 3 | 2 | 1 | 0 | 4 | 2 | 106 | 50 | 56 | 53% | 2-0 | 2.25 | 1.25 |
| 2012-05-26 | David Price | L | 27 | L 2-3 | @ BOS | 10 | 99 | - | 7.0 | 8 | 1 | 1 | 0 | 3 | 5 | 112 | 45 | 67 | 60% | 6-3 | 2.73 | 1.26 |
| 2012-05-27 | Jeremy Hellickson | R | 25 | W 4-3 | @ BOS | 10 | 43 | - | 7.2 | 7 | 3 | 3 | 1 | 2 | 3 | 105 | 35 | 70 | 67% | 4-1 | 2.81 | 1.22 |
| 2012-05-28 | Matt Moore | L | 23 | W 1-2 | vs CHA | 10 | 11 | L | 7.0 | 4 | 2 | 2 | 1 | 1 | 10 | 104 | 31 | 73 | 70% | 1-5 | 4.74 | 1.46 |
| 2012-05-29 | James Shields | R | 30 | W 2-7 | vs CHA | 11 | 195 | L | 6.0 | 10 | 6 | 5 | 0 | 1 | 8 | 96 | 30 | 66 | 69% | 6-3 | 3.95 | 1.32 |
| 2012-05-30 | Alex Cobb | R | 25 | W 3-4 | vs CHA | 3 | 12 | L | 5.0 | 9 | 4 | 4 | 0 | 1 | 4 | 91 | 29 | 62 | 68% | 2-1 | 3.71 | 1.47 |
| 2012-06-01 | David Price | L | 27 | L 5-0 | vs BAL | 11 | 100 | W | 7.1 | 4 | 0 | 0 | 0 | 2 | 5 | 112 | 43 | 69 | 62% | 7-3 | 2.43 | 1.20 |
| 2012-06-02 | Jeremy Hellickson | R | 25 | W 1-2 | vs BAL | 11 | 44 | L | 6.2 | 4 | 2 | 1 | 1 | 1 | 8 | 99 | 33 | 66 | 67% | 4-2 | 2.70 | 1.19 |
| 2012-06-03 | Matt Moore | L | 23 | L 8-4 | vs BAL | 11 | 12 | W | 6.0 | 7 | 2 | 1 | 1 | 3 | 4 | 92 | 31 | 61 | 66% | 2-5 | 4.43 | 1.48 |
| 2012-06-05 | James Shields | R | 30 | L 0-7 | @ NYA | 12 | 196 | L | 5.0 | 7 | 7 | 5 | 1 | 4 | 2 | 113 | 49 | 64 | 57% | 6-4 | 4.27 | 1.37 |
| 2012-06-06 | Alex Cobb | R | 25 | L 1-4 | @ NYA | 4 | 13 | L | 7.0 | 5 | 4 | 4 | 2 | 1 | 4 | 107 | 39 | 68 | 64% | 2-2 | 4.13 | 1.29 |
| 2012-06-07 | David Price | L | 27 | W 7-3 | @ NYA | 12 | 101 | W | 5.0 | 3 | 1 | 1 | 0 | 4 | 8 | 115 | 48 | 67 | 58% | 8-3 | 2.39 | 1.22 |
| 2012-06-08 | Jeremy Hellickson | R | 25 | W 5-1 | @ MIA | 12 | 45 | - | 4.1 | 5 | 1 | 1 | 0 | 7 | 3 | 108 | 49 | 59 | 55% | 4-2 | 2.64 | 1.27 |
| 2012-06-09 | Matt Moore | L | 23 | W 13-4 | @ MIA | 12 | 13 | W | 6.0 | 5 | 4 | 4 | 1 | 2 | 9 | 100 | 36 | 64 | 64% | 3-5 | 4.57 | 1.45 |
| 2012-06-10 | James Shields | R | 30 | W 4-2 | @ MIA | 13 | 197 | W | 6.1 | 4 | 1 | 1 | 0 | 3 | 5 | 102 | 38 | 64 | 63% | 7-4 | 4.07 | 1.36 |
| 2012-06-12 | Alex Cobb | R | 25 | W 2-11 | vs NYN | 5 | 14 | L | 6.2 | 7 | 6 | 5 | 0 | 3 | 6 | 109 | 39 | 70 | 64% | 2-3 | 4.65 | 1.32 |
| 2012-06-13 | David Price | L | 27 | W 1-9 | vs NYN | 13 | 102 | L | 5.0 | 9 | 7 | 7 | 0 | 3 | 8 | 107 | 44 | 63 | 59% | 8-4 | 3.00 | 1.29 |
| 2012-06-14 | Jeremy Hellickson | R | 25 | W 6-9 | vs NYN | 13 | 46 | L | 3.2 | 9 | 8 | 8 | 3 | 1 | 0 | 92 | 33 | 59 | 64% | 4-3 | 3.46 | 1.35 |
| 2012-06-15 | Matt Moore | L | 23 | L 11-0 | vs MIA | 13 | 14 | W | 7.0 | 1 | 0 | 0 | 0 | 3 | 8 | 105 | 40 | 65 | 62% | 4-5 | 4.14 | 1.37 |
| 2012-06-16 | James Shields | R | 30 | W 3-4 | vs MIA | 14 | 198 | - | 7.2 | 9 | 3 | 0 | 0 | 1 | 5 | 122 | 38 | 84 | 69% | 7-4 | 3.72 | 1.35 |
| 2012-06-17 | Alex Cobb | R | 25 | L 3-0 | vs MIA | 6 | 15 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 10 | 99 | 31 | 68 | 69% | 3-3 | 3.79 | 1.16 |
| 2012-06-19 | David Price | L | 27 | W 5-4 | @ WAS | 14 | 103 | W | 7.0 | 6 | 4 | 3 | 2 | 1 | 4 | 98 | 38 | 60 | 61% | 9-4 | 3.07 | 1.26 |
| 2012-06-20 | Chris Archer | R | 24 | L 2-3 | @ WAS | 1 | 1 | L | 6.0 | 3 | 3 | 1 | 0 | 1 | 7 | 86 | 35 | 51 | 59% | 0-1 | 1.50 | 0.67 |
| 2012-06-21 | Matt Moore | L | 23 | L 2-5 | @ WAS | 14 | 15 | - | 5.0 | 3 | 2 | 2 | 0 | 4 | 6 | 91 | 35 | 56 | 62% | 4-5 | 4.11 | 1.37 |
| 2012-06-23 | James Shields | R | 31 | L 6-7 | @ PHI | 15 | 199 | - | 5.0 | 7 | 5 | 5 | 2 | 1 | 7 | 111 | 39 | 72 | 65% | 7-4 | 3.99 | 1.36 |
| 2012-06-24 | David Price | L | 27 | W 3-2 | @ PHI | 15 | 104 | W | 7.0 | 4 | 1 | 1 | 1 | 3 | 8 | 116 | 38 | 78 | 67% | 10-4 | 2.94 | 1.24 |
| 2012-06-24 | Cesar Ramos | L | 28 | W 7-3 | @ PHI | 1 | 3 | - | 2.2 | 0 | 0 | 0 | 0 | 3 | 2 | 42 | 21 | 21 | 50% | 1-0 | 1.80 | 1.05 |
| 2012-06-25 | Alex Cobb | R | 25 | L 0-8 | @ KCA | 7 | 16 | L | 8.0 | 13 | 8 | 8 | 1 | 0 | 1 | 118 | 42 | 76 | 64% | 3-4 | 4.70 | 1.24 |
| 2012-06-26 | Chris Archer | R | 24 | L 2-8 | @ KCA | 2 | 2 | L | 5.2 | 5 | 4 | 4 | 1 | 1 | 7 | 98 | 41 | 57 | 58% | 0-2 | 3.75 | 0.83 |
| 2012-06-27 | Matt Moore | L | 23 | L 4-5 | @ KCA | 15 | 16 | - | 7.1 | 10 | 4 | 4 | 2 | 2 | 5 | 98 | 28 | 70 | 71% | 4-5 | 4.19 | 1.40 |
| 2012-06-28 | James Shields | R | 31 | W 2-5 | vs DET | 16 | 200 | L | 7.2 | 14 | 4 | 4 | 0 | 1 | 6 | 122 | 39 | 83 | 68% | 7-5 | 4.03 | 1.40 |
| 2012-06-29 | David Price | L | 27 | L 4-2 | vs DET | 16 | 105 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 7 | 77 | 23 | 54 | 70% | 11-4 | 2.91 | 1.22 |
| 2012-06-30 | Jeremy Hellickson | R | 25 | W 2-6 | vs DET | 14 | 47 | L | 2.2 | 4 | 1 | 1 | 0 | 1 | 1 | 40 | 14 | 26 | 65% | 4-4 | 3.44 | 1.36 |
| 2012-07-01 | Alex Cobb | R | 25 | W 3-5 | vs DET | 8 | 17 | L | 5.1 | 8 | 5 | 4 | 0 | 2 | 3 | 99 | 36 | 63 | 64% | 3-5 | 4.94 | 1.31 |
| 2012-07-02 | Matt Moore | L | 23 | L 4-3 | vs NYA | 16 | 17 | W | 7.0 | 9 | 3 | 3 | 0 | 3 | 3 | 112 | 43 | 69 | 62% | 5-5 | 4.17 | 1.42 |
| 2012-07-03 | James Shields | R | 31 | L 7-4 | vs NYA | 17 | 201 | W | 7.0 | 10 | 4 | 4 | 1 | 0 | 5 | 100 | 39 | 61 | 61% | 8-5 | 4.10 | 1.40 |
| 2012-07-04 | David Price | L | 27 | W 3-4 | vs NYA | 17 | 106 | - | 7.0 | 4 | 1 | 1 | 1 | 2 | 8 | 116 | 42 | 74 | 64% | 11-4 | 2.81 | 1.20 |
| 2012-07-05 | Jeremy Hellickson | R | 25 | L 1-3 | @ CLE | 15 | 48 | L | 6.0 | 5 | 2 | 2 | 2 | 4 | 3 | 115 | 58 | 57 | 50% | 4-5 | 3.41 | 1.37 |
| 2012-07-06 | Alex Cobb | R | 25 | W 10-3 | @ CLE | 9 | 18 | W | 6.0 | 6 | 3 | 3 | 0 | 2 | 4 | 100 | 43 | 57 | 57% | 4-5 | 4.89 | 1.32 |
| 2012-07-07 | Matt Moore | L | 23 | L 3-7 | @ CLE | 17 | 18 | L | 4.2 | 5 | 5 | 5 | 0 | 5 | 3 | 96 | 42 | 54 | 56% | 5-6 | 4.41 | 1.45 |
| 2012-07-08 | James Shields | R | 31 | W 7-6 | @ CLE | 18 | 202 | - | 7.0 | 10 | 5 | 4 | 1 | 2 | 5 | 123 | 48 | 75 | 61% | 8-5 | 4.16 | 1.42 |
| 2012-07-13 | Jeremy Hellickson | R | 25 | W 1-3 | vs BOS | 16 | 49 | L | 6.0 | 5 | 3 | 3 | 1 | 4 | 5 | 113 | 48 | 65 | 58% | 4-6 | 3.48 | 1.38 |
| 2012-07-14 | David Price | L | 27 | L 5-3 | vs BOS | 18 | 107 | W | 7.1 | 6 | 3 | 2 | 1 | 3 | 8 | 119 | 46 | 73 | 61% | 12-4 | 2.80 | 1.20 |
| 2012-07-15 | James Shields | R | 31 | W 3-7 | vs BOS | 19 | 203 | L | 5.0 | 11 | 6 | 6 | 2 | 3 | 5 | 112 | 48 | 64 | 57% | 8-6 | 4.43 | 1.48 |
| 2012-07-16 | Alex Cobb | R | 25 | W 2-3 | vs CLE | 10 | 19 | L | 3.1 | 5 | 3 | 2 | 0 | 5 | 3 | 86 | 43 | 43 | 50% | 4-6 | 4.95 | 1.42 |
| 2012-07-17 | Matt Moore | L | 23 | L 4-2 | vs CLE | 18 | 19 | W | 5.0 | 3 | 2 | 2 | 0 | 5 | 3 | 90 | 39 | 51 | 57% | 6-6 | 4.37 | 1.46 |
| 2012-07-18 | Jeremy Hellickson | R | 25 | W 6-10 | vs CLE | 17 | 50 | - | 6.0 | 5 | 3 | 3 | 0 | 1 | 2 | 96 | 34 | 62 | 65% | 4-6 | 3.55 | 1.35 |
| 2012-07-19 | David Price | L | 27 | L 6-0 | vs CLE | 19 | 108 | W | 7.0 | 2 | 0 | 0 | 0 | 3 | 7 | 108 | 42 | 66 | 61% | 13-4 | 2.64 | 1.17 |
| 2012-07-20 | James Shields | R | 31 | L 4-3 | vs SEA | 20 | 204 | - | 7.2 | 4 | 3 | 3 | 1 | 2 | 10 | 105 | 39 | 66 | 63% | 8-6 | 4.40 | 1.44 |
| 2012-07-21 | Alex Cobb | R | 25 | W 1-2 | vs SEA | 11 | 20 | L | 2.0 | 3 | 2 | 2 | 0 | 2 | 3 | 52 | 21 | 31 | 60% | 4-7 | 5.08 | 1.45 |
| 2012-07-22 | Matt Moore | L | 23 | W 1-2 | vs SEA | 19 | 20 | L | 8.0 | 5 | 2 | 2 | 0 | 0 | 7 | 104 | 32 | 72 | 69% | 6-7 | 4.22 | 1.40 |
| 2012-07-24 | Jeremy Hellickson | R | 25 | W 3-1 | @ BAL | 18 | 51 | W | 6.1 | 3 | 1 | 1 | 1 | 0 | 4 | 94 | 35 | 59 | 63% | 5-6 | 3.43 | 1.30 |
| 2012-07-25 | David Price | L | 27 | W 10-1 | @ BAL | 20 | 109 | W | 7.0 | 7 | 1 | 1 | 0 | 0 | 10 | 106 | 38 | 68 | 64% | 14-4 | 2.57 | 1.17 |
| 2012-07-26 | James Shields | R | 31 | L 2-6 | @ BAL | 21 | 205 | L | 6.0 | 6 | 5 | 5 | 0 | 5 | 10 | 105 | 38 | 67 | 64% | 8-7 | 4.53 | 1.46 |
| 2012-07-27 | Alex Cobb | R | 25 | L 1-3 | @ ANA | 12 | 21 | L | 7.0 | 8 | 3 | 3 | 0 | 0 | 3 | 102 | 32 | 70 | 69% | 4-8 | 4.96 | 1.42 |
| 2012-07-28 | Matt Moore | L | 23 | W 3-0 | @ ANA | 20 | 21 | W | 6.1 | 4 | 0 | 0 | 0 | 2 | 6 | 102 | 31 | 71 | 70% | 7-7 | 4.01 | 1.38 |
| 2012-07-29 | Jeremy Hellickson | R | 25 | W 2-0 | @ ANA | 19 | 52 | W | 6.0 | 2 | 0 | 0 | 0 | 0 | 5 | 85 | 32 | 53 | 62% | 6-6 | 3.24 | 1.25 |
| 2012-07-30 | David Price | L | 27 | L 3-4 | @ OAK | 21 | 110 | - | 7.0 | 5 | 3 | 3 | 1 | 2 | 11 | 121 | 38 | 83 | 69% | 14-4 | 2.64 | 1.16 |
| 2012-07-31 | James Shields | R | 31 | W 8-0 | @ OAK | 22 | 206 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 11 | 98 | 32 | 66 | 67% | 9-7 | 4.25 | 1.39 |
| 2012-08-01 | Alex Cobb | R | 25 | W 4-1 | @ OAK | 13 | 22 | W | 7.0 | 4 | 1 | 1 | 1 | 1 | 6 | 93 | 27 | 66 | 71% | 5-8 | 4.62 | 1.36 |
| 2012-08-03 | Matt Moore | L | 23 | L 2-0 | vs BAL | 21 | 22 | W | 5.1 | 6 | 0 | 0 | 0 | 3 | 6 | 107 | 40 | 67 | 63% | 8-7 | 3.85 | 1.40 |
| 2012-08-04 | Jeremy Hellickson | R | 25 | W 0-4 | vs BAL | 20 | 53 | L | 4.0 | 8 | 4 | 4 | 0 | 4 | 4 | 86 | 35 | 51 | 59% | 6-7 | 3.44 | 1.31 |
| 2012-08-05 | David Price | L | 27 | W 0-1 | vs BAL | 22 | 111 | - | 8.0 | 2 | 0 | 0 | 0 | 3 | 5 | 109 | 42 | 67 | 61% | 14-4 | 2.49 | 1.13 |
| 2012-08-07 | James Shields | R | 31 | L 4-1 | vs TOR | 23 | 207 | W | 8.0 | 2 | 1 | 1 | 1 | 1 | 6 | 114 | 49 | 65 | 57% | 10-7 | 4.09 | 1.34 |
| 2012-08-08 | Alex Cobb | R | 25 | L 3-2 | vs TOR | 14 | 23 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 7 | 102 | 30 | 72 | 71% | 6-8 | 4.34 | 1.30 |
| 2012-08-09 | Matt Moore | L | 23 | L 7-1 | vs TOR | 22 | 23 | W | 6.0 | 2 | 1 | 1 | 0 | 2 | 6 | 99 | 40 | 59 | 60% | 9-7 | 3.74 | 1.36 |
| 2012-08-10 | Jeremy Hellickson | R | 25 | W 12-6 | @ MIN | 21 | 54 | W | 5.0 | 7 | 3 | 3 | 1 | 2 | 3 | 97 | 35 | 62 | 64% | 7-7 | 3.53 | 1.33 |
| 2012-08-11 | David Price | L | 27 | W 4-2 | @ MIN | 23 | 112 | W | 7.0 | 7 | 2 | 2 | 1 | 0 | 5 | 101 | 32 | 69 | 68% | 15-4 | 2.50 | 1.12 |
| 2012-08-12 | James Shields | R | 31 | W 7-3 | @ MIN | 24 | 208 | - | 7.0 | 5 | 3 | 2 | 1 | 1 | 2 | 104 | 43 | 61 | 59% | 10-7 | 4.02 | 1.32 |
| 2012-08-13 | Alex Cobb | R | 25 | W 4-1 | @ SEA | 15 | 24 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 5 | 97 | 34 | 63 | 65% | 7-8 | 4.10 | 1.27 |
| 2012-08-14 | Matt Moore | L | 23 | L 2-3 | @ SEA | 23 | 24 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 9 | 93 | 25 | 68 | 73% | 9-7 | 3.61 | 1.34 |
| 2012-08-15 | Jeremy Hellickson | R | 25 | L 0-1 | @ SEA | 22 | 55 | L | 7.0 | 5 | 1 | 1 | 0 | 1 | 1 | 116 | 44 | 72 | 62% | 7-8 | 3.40 | 1.31 |
| 2012-08-16 | David Price | L | 27 | W 7-0 | @ ANA | 24 | 113 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 8 | 103 | 37 | 66 | 64% | 16-4 | 2.39 | 1.10 |
| 2012-08-17 | James Shields | R | 31 | W 12-3 | @ ANA | 25 | 209 | W | 6.0 | 7 | 3 | 3 | 2 | 0 | 8 | 102 | 34 | 68 | 67% | 11-7 | 4.04 | 1.31 |
| 2012-08-18 | Alex Cobb | R | 25 | W 10-8 | @ ANA | 16 | 25 | - | 2.2 | 12 | 8 | 8 | 2 | 0 | 1 | 61 | 19 | 42 | 69% | 7-8 | 4.74 | 1.35 |
| 2012-08-19 | Matt Moore | L | 23 | W 8-3 | @ ANA | 24 | 25 | W | 6.1 | 5 | 2 | 2 | 2 | 2 | 5 | 92 | 33 | 59 | 64% | 10-7 | 3.56 | 1.33 |
| 2012-08-20 | Jeremy Hellickson | R | 25 | L 5-1 | vs KCA | 23 | 56 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 6 | 98 | 33 | 65 | 66% | 8-8 | 3.29 | 1.29 |
| 2012-08-21 | David Price | L | 27 | W 0-1 | vs KCA | 25 | 114 | - | 8.0 | 3 | 0 | 0 | 0 | 0 | 8 | 111 | 34 | 77 | 69% | 16-4 | 2.28 | 1.07 |
| 2012-08-22 | James Shields | R | 31 | L 5-3 | vs KCA | 26 | 210 | W | 7.2 | 5 | 3 | 3 | 0 | 1 | 7 | 106 | 35 | 71 | 67% | 12-7 | 4.01 | 1.29 |
| 2012-08-23 | Alex Cobb | R | 25 | L 5-0 | vs OAK | 17 | 26 | W | 9.0 | 4 | 0 | 0 | 0 | 2 | 8 | 111 | 34 | 77 | 69% | 8-8 | 4.32 | 1.29 |
| 2012-08-24 | Matt Moore | L | 23 | W 4-5 | vs OAK | 25 | 26 | - | 6.1 | 7 | 3 | 3 | 0 | 1 | 7 | 96 | 34 | 62 | 65% | 10-7 | 3.60 | 1.33 |
| 2012-08-25 | Jeremy Hellickson | R | 25 | W 2-4 | vs OAK | 24 | 57 | L | 5.0 | 6 | 4 | 4 | 2 | 0 | 5 | 97 | 37 | 60 | 62% | 8-9 | 3.43 | 1.29 |
| 2012-08-27 | David Price | L | 27 | L 5-6 | @ TEX | 26 | 115 | L | 4.0 | 10 | 6 | 6 | 2 | 0 | 3 | 68 | 16 | 52 | 76% | 16-5 | 2.53 | 1.10 |
| 2012-08-28 | James Shields | R | 31 | L 0-1 | @ TEX | 27 | 211 | L | 7.0 | 3 | 1 | 1 | 1 | 2 | 8 | 121 | 43 | 78 | 64% | 12-8 | 3.91 | 1.26 |
| 2012-08-29 | Alex Cobb | R | 25 | W 8-4 | @ TEX | 18 | 27 | - | 4.2 | 8 | 4 | 3 | 2 | 1 | 3 | 100 | 32 | 68 | 68% | 8-8 | 4.37 | 1.32 |
| 2012-08-30 | Matt Moore | L | 23 | L 0-2 | @ TOR | 26 | 27 | L | 6.0 | 6 | 2 | 2 | 0 | 3 | 7 | 97 | 39 | 58 | 60% | 10-8 | 3.58 | 1.33 |
| 2012-08-31 | Jeremy Hellickson | R | 25 | L 1-2 | @ TOR | 25 | 58 | L | 6.0 | 4 | 2 | 2 | 2 | 1 | 2 | 74 | 28 | 46 | 62% | 8-10 | 3.41 | 1.27 |
| 2012-09-01 | Jeff Niemann | R | 30 | W 5-4 | @ TOR | 8 | 92 | - | 3.1 | 1 | 0 | 0 | 0 | 0 | 4 | 44 | 16 | 28 | 64% | 2-3 | 3.08 | 1.11 |
| 2012-09-02 | David Price | L | 27 | W 9-4 | @ TOR | 27 | 116 | W | 6.2 | 6 | 2 | 2 | 0 | 4 | 5 | 103 | 39 | 64 | 62% | 17-5 | 2.54 | 1.12 |
| 2012-09-03 | James Shields | R | 31 | L 4-3 | vs NYA | 28 | 212 | W | 8.0 | 5 | 3 | 3 | 0 | 3 | 5 | 120 | 47 | 73 | 61% | 13-8 | 3.88 | 1.25 |
| 2012-09-04 | Alex Cobb | R | 25 | L 5-2 | vs NYA | 19 | 28 | W | 7.0 | 4 | 2 | 2 | 1 | 1 | 5 | 95 | 29 | 66 | 69% | 9-8 | 4.26 | 1.28 |
| 2012-09-05 | Matt Moore | L | 23 | W 4-6 | vs NYA | 27 | 28 | L | 6.1 | 8 | 6 | 4 | 1 | 1 | 9 | 102 | 35 | 67 | 66% | 10-9 | 3.67 | 1.34 |
| 2012-09-07 | Jeremy Hellickson | R | 25 | L 3-1 | vs TEX | 26 | 59 | - | 6.0 | 4 | 1 | 1 | 1 | 1 | 5 | 95 | 32 | 63 | 66% | 8-10 | 3.34 | 1.25 |
| 2012-09-08 | Chris Archer | R | 24 | W 2-4 | vs TEX | 3 | 3 | - | 7.0 | 4 | 2 | 2 | 1 | 2 | 11 | 98 | 31 | 67 | 68% | 0-2 | 3.32 | 0.84 |
| 2012-09-09 | James Shields | R | 31 | L 6-0 | vs TEX | 29 | 213 | W | 9.0 | 2 | 0 | 0 | 0 | 0 | 8 | 101 | 30 | 71 | 70% | 14-8 | 3.71 | 1.21 |
| 2012-09-11 | Matt Moore | L | 23 | L 2-9 | @ BAL | 28 | 29 | L | 4.0 | 4 | 3 | 2 | 1 | 3 | 4 | 94 | 37 | 57 | 61% | 10-10 | 3.69 | 1.35 |
| 2012-09-12 | Alex Cobb | R | 25 | L 2-3 | @ BAL | 20 | 29 | - | 4.2 | 7 | 2 | 2 | 0 | 2 | 6 | 95 | 39 | 56 | 59% | 9-8 | 4.27 | 1.31 |
| 2012-09-13 | Jeremy Hellickson | R | 25 | L 2-3 | @ BAL | 27 | 60 | - | 5.0 | 4 | 0 | 0 | 0 | 3 | 5 | 93 | 36 | 57 | 61% | 8-10 | 3.23 | 1.26 |
| 2012-09-14 | David Price | L | 27 | W 6-4 | @ NYA | 28 | 117 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 6 | 105 | 36 | 69 | 66% | 18-5 | 2.54 | 1.11 |
| 2012-09-15 | James Shields | R | 31 | L 3-5 | @ NYA | 30 | 214 | L | 6.1 | 6 | 4 | 4 | 2 | 1 | 4 | 107 | 39 | 68 | 64% | 14-9 | 3.78 | 1.20 |
| 2012-09-16 | Matt Moore | L | 23 | L 4-6 | @ NYA | 29 | 30 | L | 3.0 | 3 | 5 | 5 | 1 | 4 | 4 | 85 | 36 | 49 | 58% | 10-11 | 3.89 | 1.37 |
| 2012-09-17 | Alex Cobb | R | 25 | W 2-5 | vs BOS | 21 | 30 | L | 6.0 | 2 | 4 | 3 | 1 | 3 | 4 | 101 | 39 | 62 | 61% | 9-9 | 4.28 | 1.29 |
| 2012-09-18 | Jeremy Hellickson | R | 25 | W 5-7 | vs BOS | 28 | 61 | - | 4.0 | 5 | 3 | 3 | 0 | 2 | 7 | 94 | 32 | 62 | 66% | 8-10 | 3.32 | 1.27 |
| 2012-09-19 | Chris Archer | R | 24 | L 13-3 | vs BOS | 4 | 4 | W | 5.0 | 5 | 3 | 3 | 0 | 4 | 6 | 95 | 37 | 58 | 61% | 1-3 | 3.67 | 1.15 |
| 2012-09-20 | David Price | L | 27 | L 7-4 | vs BOS | 29 | 118 | - | 7.1 | 8 | 3 | 3 | 0 | 1 | 7 | 117 | 36 | 81 | 69% | 18-5 | 2.58 | 1.12 |
| 2012-09-21 | James Shields | R | 31 | L 12-1 | vs TOR | 31 | 215 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 9 | 105 | 33 | 72 | 69% | 15-9 | 3.65 | 1.20 |
| 2012-09-22 | Matt Moore | L | 23 | L 11-5 | vs TOR | 30 | 31 | - | 2.2 | 3 | 2 | 2 | 0 | 2 | 2 | 50 | 20 | 30 | 60% | 10-11 | 3.92 | 1.37 |
| 2012-09-23 | Jeremy Hellickson | R | 25 | L 3-0 | vs TOR | 29 | 62 | W | 5.2 | 5 | 0 | 0 | 0 | 2 | 6 | 95 | 35 | 60 | 63% | 9-10 | 3.20 | 1.27 |
| 2012-09-25 | David Price | L | 27 | W 5-2 | @ BOS | 30 | 119 | W | 9.0 | 7 | 2 | 2 | 0 | 0 | 13 | 117 | 30 | 87 | 74% | 19-5 | 2.56 | 1.10 |
| 2012-09-26 | Alex Cobb | R | 25 | W 4-2 | @ BOS | 22 | 31 | W | 5.0 | 3 | 1 | 1 | 0 | 3 | 5 | 94 | 38 | 56 | 60% | 10-9 | 4.19 | 1.29 |
| 2012-09-27 | James Shields | R | 31 | W 3-2 | @ CHA | 32 | 216 | - | 6.1 | 6 | 2 | 2 | 0 | 4 | 6 | 121 | 50 | 71 | 59% | 15-9 | 3.62 | 1.21 |
| 2012-09-28 | Jeremy Hellickson | R | 25 | L 1-3 | @ CHA | 30 | 63 | L | 5.2 | 9 | 3 | 2 | 1 | 1 | 2 | 95 | 33 | 62 | 65% | 9-11 | 3.19 | 1.28 |
| 2012-09-29 | Matt Moore | L | 23 | W 10-4 | @ CHA | 31 | 32 | W | 5.1 | 1 | 0 | 0 | 0 | 2 | 4 | 76 | 34 | 42 | 55% | 11-11 | 3.81 | 1.35 |
| 2012-09-30 | David Price | L | 27 | W 6-2 | @ CHA | 31 | 120 | W | 7.0 | 5 | 2 | 2 | 0 | 2 | 4 | 108 | 37 | 71 | 66% | 20-5 | 2.56 | 1.10 |
| 2012-10-01 | Alex Cobb | R | 25 | L 5-3 | vs BAL | 23 | 32 | W | 7.0 | 2 | 1 | 1 | 1 | 2 | 7 | 87 | 26 | 61 | 70% | 11-9 | 4.04 | 1.25 |
| 2012-10-02 | James Shields | R | 31 | W 0-1 | vs BAL | 33 | 217 | L | 9.0 | 2 | 1 | 1 | 1 | 0 | 15 | 104 | 36 | 68 | 65% | 15-10 | 3.51 | 1.17 |
| 2012-10-03 | Jeremy Hellickson | R | 25 | L 4-1 | vs BAL | 31 | 64 | W | 5.1 | 1 | 0 | 0 | 0 | 1 | 6 | 80 | 27 | 53 | 66% | 10-11 | 3.10 | 1.25 |