| Central | W | L | Pct | GB |
| Cincinnati | 97 | 65 | .599 | -- |
| St. Louis | 88 | 74 | .543 | 9.0 |
| Milwaukee | 83 | 79 | .512 | 14.0 |
| Pittsburgh | 79 | 83 | .488 | 18.0 |
| Chi Cubs | 61 | 101 | .377 | 36.0 |
| Houston | 55 | 107 | .340 | 42.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-05 | Erik Bedard | L | 33 | W 0-1 | vs PHI | 1 | 166 | L | 7.0 | 6 | 1 | 1 | 0 | 1 | 4 | 81 | 23 | 58 | 72% | 0-1 | 1.29 | 1.00 |
| 2012-04-07 | Jeff Karstens | R | 30 | L 2-1 | vs PHI | 1 | 77 | - | 6.0 | 5 | 1 | 1 | 0 | 1 | 2 | 85 | 31 | 54 | 64% | 0-0 | 1.50 | 1.00 |
| 2012-04-08 | James McDonald | R | 27 | L 5-4 | vs PHI | 1 | 48 | - | 6.0 | 4 | 2 | 2 | 1 | 2 | 3 | 82 | 31 | 51 | 62% | 0-0 | 3.00 | 1.00 |
| 2012-04-10 | Kevin Correia | R | 32 | L 1-2 | @ LAN | 1 | 132 | - | 6.0 | 4 | 1 | 1 | 0 | 2 | 3 | 80 | 30 | 50 | 63% | 0-0 | 1.50 | 1.00 |
| 2012-04-11 | Erik Bedard | L | 33 | L 1-4 | @ LAN | 2 | 167 | L | 5.0 | 8 | 2 | 2 | 0 | 1 | 3 | 90 | 32 | 58 | 64% | 0-2 | 2.25 | 1.33 |
| 2012-04-12 | Jeff Karstens | R | 30 | L 2-3 | @ LAN | 2 | 78 | L | 5.0 | 7 | 3 | 3 | 0 | 1 | 3 | 71 | 22 | 49 | 69% | 0-1 | 3.27 | 1.27 |
| 2012-04-13 | James McDonald | R | 27 | L 0-5 | @ SFN | 2 | 49 | L | 5.2 | 6 | 3 | 3 | 0 | 3 | 1 | 90 | 45 | 45 | 50% | 0-1 | 3.75 | 1.25 |
| 2012-04-14 | Charlie Morton | R | 28 | L 3-4 | @ SFN | 1 | 80 | - | 5.0 | 7 | 3 | 3 | 0 | 0 | 2 | 71 | 21 | 50 | 70% | 0-0 | 5.40 | 1.40 |
| 2012-04-15 | Kevin Correia | R | 32 | W 4-1 | @ SFN | 2 | 133 | W | 6.0 | 3 | 1 | 1 | 0 | 1 | 2 | 91 | 29 | 62 | 68% | 1-0 | 1.50 | 0.83 |
| 2012-04-16 | Erik Bedard | L | 33 | L 1-5 | @ ARI | 3 | 168 | L | 5.0 | 3 | 2 | 2 | 1 | 4 | 3 | 104 | 50 | 54 | 52% | 0-3 | 2.65 | 1.35 |
| 2012-04-17 | Jeff Karstens | R | 30 | W 5-4 | @ ARI | 3 | 79 | - | 1.0 | 3 | 2 | 2 | 0 | 0 | 0 | 20 | 5 | 15 | 75% | 0-1 | 4.50 | 1.42 |
| 2012-04-18 | James McDonald | R | 27 | W 2-1 | @ ARI | 3 | 50 | - | 4.0 | 3 | 1 | 1 | 0 | 1 | 2 | 78 | 33 | 45 | 58% | 0-1 | 3.38 | 1.19 |
| 2012-04-20 | Charlie Morton | R | 28 | W 1-4 | vs SLN | 2 | 81 | L | 5.0 | 4 | 2 | 1 | 0 | 3 | 6 | 92 | 34 | 58 | 63% | 0-1 | 3.60 | 1.40 |
| 2012-04-21 | A.J. Burnett | R | 35 | L 2-0 | vs SLN | 1 | 310 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 7 | 76 | 23 | 53 | 70% | 1-0 | 0.00 | 0.71 |
| 2012-04-22 | Erik Bedard | L | 33 | W 1-5 | vs SLN | 4 | 169 | L | 7.0 | 7 | 3 | 2 | 0 | 4 | 7 | 101 | 38 | 63 | 62% | 0-4 | 2.63 | 1.42 |
| 2012-04-24 | Kevin Correia | R | 32 | L 5-4 | vs COL | 3 | 134 | - | 6.0 | 4 | 2 | 2 | 1 | 0 | 4 | 93 | 36 | 57 | 61% | 1-0 | 2.00 | 0.78 |
| 2012-04-25 | James McDonald | R | 28 | W 1-2 | vs COL | 4 | 51 | - | 7.0 | 1 | 1 | 1 | 0 | 3 | 8 | 100 | 48 | 52 | 52% | 0-1 | 2.74 | 1.00 |
| 2012-04-25 | Charlie Morton | R | 28 | L 5-1 | vs COL | 3 | 82 | W | 7.0 | 6 | 1 | 1 | 1 | 1 | 2 | 101 | 41 | 60 | 59% | 1-1 | 2.65 | 1.24 |
| 2012-04-27 | A.J. Burnett | R | 35 | L 1-6 | @ ATL | 2 | 311 | L | 6.0 | 6 | 2 | 2 | 0 | 3 | 8 | 98 | 38 | 60 | 61% | 1-1 | 1.38 | 1.08 |
| 2012-04-28 | Erik Bedard | L | 33 | W 4-2 | @ ATL | 5 | 170 | W | 5.0 | 5 | 1 | 1 | 0 | 2 | 9 | 99 | 35 | 64 | 65% | 1-4 | 2.48 | 1.41 |
| 2012-04-29 | Kevin Correia | R | 32 | L 3-4 | @ ATL | 4 | 135 | L | 4.1 | 4 | 3 | 2 | 0 | 5 | 0 | 101 | 48 | 53 | 52% | 1-1 | 2.45 | 1.05 |
| 2012-04-30 | James McDonald | R | 28 | W 9-3 | @ ATL | 5 | 52 | W | 7.2 | 7 | 3 | 3 | 1 | 2 | 10 | 115 | 43 | 72 | 63% | 1-1 | 3.00 | 1.07 |
| 2012-05-01 | Charlie Morton | R | 28 | L 7-10 | @ SLN | 4 | 83 | L | 4.1 | 8 | 6 | 5 | 1 | 2 | 5 | 100 | 34 | 66 | 66% | 1-2 | 4.29 | 1.48 |
| 2012-05-02 | A.J. Burnett | R | 35 | L 3-12 | @ SLN | 3 | 312 | L | 2.2 | 12 | 12 | 12 | 2 | 1 | 2 | 76 | 33 | 43 | 57% | 1-2 | 7.88 | 1.69 |
| 2012-05-03 | Erik Bedard | L | 33 | W 6-3 | @ SLN | 6 | 171 | W | 5.0 | 5 | 2 | 2 | 0 | 2 | 11 | 106 | 37 | 69 | 65% | 2-4 | 2.65 | 1.41 |
| 2012-05-04 | Kevin Correia | R | 32 | W 1-6 | vs CIN | 5 | 136 | L | 7.0 | 9 | 5 | 5 | 2 | 1 | 3 | 103 | 36 | 67 | 65% | 1-2 | 3.41 | 1.14 |
| 2012-05-05 | James McDonald | R | 28 | L 3-2 | vs CIN | 6 | 53 | W | 6.1 | 6 | 1 | 1 | 0 | 2 | 7 | 99 | 32 | 67 | 68% | 2-1 | 2.68 | 1.08 |
| 2012-05-06 | Charlie Morton | R | 28 | W 0-5 | vs CIN | 5 | 84 | L | 6.0 | 7 | 5 | 4 | 2 | 2 | 5 | 96 | 35 | 61 | 64% | 1-3 | 4.67 | 1.48 |
| 2012-05-08 | A.J. Burnett | R | 35 | L 5-4 | vs WAS | 4 | 313 | - | 8.0 | 6 | 2 | 2 | 1 | 1 | 10 | 93 | 29 | 64 | 69% | 1-2 | 6.00 | 1.42 |
| 2012-05-09 | Erik Bedard | L | 33 | L 4-2 | vs WAS | 7 | 172 | - | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 4 | 80% | 2-4 | 2.57 | 1.37 |
| 2012-05-10 | Kevin Correia | R | 32 | W 2-4 | vs WAS | 6 | 137 | L | 7.0 | 6 | 3 | 3 | 2 | 2 | 1 | 81 | 26 | 55 | 68% | 1-3 | 3.50 | 1.14 |
| 2012-05-11 | James McDonald | R | 28 | W 0-1 | vs HOU | 7 | 54 | L | 8.0 | 4 | 1 | 1 | 0 | 2 | 8 | 104 | 34 | 70 | 67% | 2-2 | 2.40 | 1.02 |
| 2012-05-12 | Charlie Morton | R | 28 | L 5-2 | vs HOU | 6 | 85 | W | 6.0 | 7 | 2 | 1 | 0 | 1 | 0 | 88 | 34 | 54 | 61% | 2-3 | 4.09 | 1.45 |
| 2012-05-13 | A.J. Burnett | R | 35 | L 3-2 | vs HOU | 5 | 314 | - | 8.0 | 6 | 2 | 2 | 0 | 0 | 4 | 99 | 30 | 69 | 70% | 1-2 | 5.06 | 1.25 |
| 2012-05-14 | Brad Lincoln | R | 27 | W 3-2 | @ MIA | 1 | 18 | W | 6.0 | 4 | 2 | 2 | 1 | 1 | 3 | 84 | 27 | 57 | 68% | 3-0 | 1.35 | 1.00 |
| 2012-05-15 | Kevin Correia | R | 32 | L 2-6 | @ MIA | 7 | 138 | L | 3.2 | 8 | 6 | 6 | 0 | 4 | 1 | 66 | 28 | 38 | 58% | 1-4 | 4.50 | 1.33 |
| 2012-05-16 | Erik Bedard | L | 33 | L 4-7 | @ WAS | 8 | 173 | L | 6.0 | 6 | 4 | 4 | 3 | 1 | 7 | 91 | 30 | 61 | 67% | 2-5 | 3.07 | 1.34 |
| 2012-05-17 | James McDonald | R | 28 | W 5-3 | @ WAS | 8 | 55 | W | 5.2 | 4 | 3 | 3 | 0 | 1 | 11 | 85 | 26 | 59 | 69% | 3-2 | 2.70 | 1.02 |
| 2012-05-18 | Charlie Morton | R | 29 | L 0-6 | @ DET | 7 | 86 | L | 6.0 | 9 | 4 | 4 | 1 | 1 | 4 | 95 | 34 | 61 | 64% | 2-4 | 4.38 | 1.49 |
| 2012-05-19 | A.J. Burnett | R | 35 | W 4-3 | @ DET | 6 | 315 | W | 6.0 | 7 | 2 | 2 | 1 | 3 | 2 | 116 | 43 | 73 | 63% | 2-2 | 4.74 | 1.32 |
| 2012-05-20 | Kevin Correia | R | 32 | L 3-4 | @ DET | 8 | 139 | L | 6.0 | 4 | 3 | 3 | 1 | 0 | 2 | 79 | 23 | 56 | 71% | 1-5 | 4.50 | 1.24 |
| 2012-05-21 | Erik Bedard | L | 33 | L 5-4 | vs NYN | 9 | 174 | - | 5.0 | 6 | 4 | 4 | 0 | 3 | 4 | 97 | 43 | 54 | 56% | 2-5 | 3.52 | 1.39 |
| 2012-05-22 | James McDonald | R | 28 | W 2-3 | vs NYN | 9 | 56 | - | 7.0 | 4 | 1 | 1 | 0 | 2 | 8 | 104 | 33 | 71 | 68% | 3-2 | 2.53 | 1.00 |
| 2012-05-23 | Charlie Morton | R | 29 | W 1-3 | vs NYN | 8 | 87 | L | 7.0 | 8 | 3 | 3 | 0 | 0 | 1 | 97 | 31 | 66 | 68% | 2-5 | 4.30 | 1.43 |
| 2012-05-25 | A.J. Burnett | R | 35 | L 1-0 | vs CHN | 7 | 316 | W | 5.1 | 6 | 0 | 0 | 0 | 2 | 6 | 105 | 40 | 65 | 62% | 3-2 | 4.19 | 1.35 |
| 2012-05-26 | Kevin Correia | R | 32 | L 3-2 | vs CHN | 9 | 140 | - | 6.1 | 5 | 2 | 2 | 1 | 2 | 2 | 76 | 27 | 49 | 64% | 1-5 | 4.33 | 1.23 |
| 2012-05-27 | Erik Bedard | L | 33 | L 10-4 | vs CHN | 10 | 175 | W | 6.0 | 2 | 0 | 0 | 0 | 4 | 3 | 88 | 37 | 51 | 58% | 3-5 | 3.12 | 1.35 |
| 2012-05-28 | James McDonald | R | 28 | L 4-1 | vs CIN | 10 | 57 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 5 | 101 | 38 | 63 | 62% | 4-2 | 2.22 | 0.97 |
| 2012-05-29 | Charlie Morton | R | 29 | W 1-8 | vs CIN | 9 | 88 | L | 4.0 | 6 | 3 | 4 | 0 | 1 | 0 | 59 | 20 | 39 | 66% | 2-6 | 4.68 | 1.46 |
| 2012-05-30 | A.J. Burnett | R | 35 | L 2-1 | vs CIN | 8 | 317 | W | 7.0 | 2 | 1 | 0 | 0 | 2 | 3 | 103 | 38 | 65 | 63% | 4-2 | 3.60 | 1.24 |
| 2012-06-01 | Kevin Correia | R | 32 | W 8-2 | @ MIL | 10 | 141 | W | 5.2 | 5 | 2 | 2 | 2 | 2 | 2 | 90 | 33 | 57 | 63% | 2-5 | 4.19 | 1.22 |
| 2012-06-02 | Erik Bedard | L | 33 | L 1-5 | @ MIL | 11 | 176 | L | 3.2 | 5 | 5 | 5 | 1 | 3 | 5 | 87 | 34 | 53 | 61% | 3-6 | 3.70 | 1.39 |
| 2012-06-03 | James McDonald | R | 28 | W 6-5 | @ MIL | 11 | 58 | W | 6.0 | 4 | 3 | 1 | 1 | 1 | 8 | 103 | 42 | 61 | 59% | 5-2 | 2.15 | 0.96 |
| 2012-06-05 | A.J. Burnett | R | 35 | W 8-4 | @ CIN | 9 | 318 | W | 5.0 | 5 | 3 | 3 | 0 | 4 | 8 | 105 | 46 | 59 | 56% | 5-2 | 3.76 | 1.29 |
| 2012-06-06 | Brad Lincoln | R | 27 | L 4-5 | @ CIN | 2 | 19 | L | 4.0 | 6 | 5 | 5 | 1 | 2 | 5 | 65 | 27 | 38 | 58% | 3-1 | 2.40 | 1.07 |
| 2012-06-07 | Kevin Correia | R | 32 | W 5-4 | @ CIN | 11 | 142 | - | 5.0 | 8 | 3 | 3 | 2 | 1 | 4 | 71 | 22 | 49 | 69% | 2-5 | 4.29 | 1.27 |
| 2012-06-08 | Erik Bedard | L | 33 | L 4-2 | vs KCA | 12 | 177 | W | 7.0 | 5 | 2 | 2 | 0 | 3 | 5 | 96 | 30 | 66 | 69% | 4-6 | 3.57 | 1.37 |
| 2012-06-09 | James McDonald | R | 28 | L 5-3 | vs KCA | 12 | 59 | - | 4.0 | 5 | 3 | 3 | 1 | 2 | 2 | 76 | 30 | 46 | 61% | 5-2 | 2.40 | 1.00 |
| 2012-06-10 | A.J. Burnett | R | 35 | L 3-2 | vs KCA | 10 | 319 | W | 7.1 | 5 | 2 | 2 | 0 | 2 | 6 | 106 | 36 | 70 | 66% | 6-2 | 3.63 | 1.26 |
| 2012-06-12 | Brad Lincoln | R | 27 | L 6-8 | @ BAL | 3 | 20 | L | 4.1 | 9 | 4 | 4 | 2 | 1 | 3 | 87 | 31 | 56 | 64% | 3-2 | 3.18 | 1.24 |
| 2012-06-13 | Kevin Correia | R | 32 | L 1-7 | @ BAL | 12 | 143 | L | 6.0 | 10 | 5 | 4 | 1 | 1 | 1 | 93 | 39 | 54 | 58% | 2-6 | 4.43 | 1.32 |
| 2012-06-14 | Erik Bedard | L | 33 | L 6-12 | @ BAL | 13 | 178 | L | 3.1 | 8 | 7 | 7 | 0 | 2 | 1 | 83 | 30 | 53 | 64% | 4-7 | 4.36 | 1.45 |
| 2012-06-15 | James McDonald | R | 28 | L 0-2 | @ CLE | 13 | 60 | L | 6.0 | 3 | 1 | 1 | 0 | 2 | 5 | 100 | 47 | 53 | 53% | 5-3 | 2.33 | 0.99 |
| 2012-06-16 | A.J. Burnett | R | 35 | W 9-2 | @ CLE | 11 | 320 | W | 6.2 | 6 | 2 | 2 | 2 | 4 | 2 | 97 | 39 | 58 | 60% | 7-2 | 3.52 | 1.28 |
| 2012-06-17 | Brad Lincoln | R | 27 | W 9-5 | @ CLE | 4 | 21 | - | 3.1 | 8 | 4 | 4 | 1 | 1 | 2 | 69 | 22 | 47 | 68% | 3-2 | 3.79 | 1.34 |
| 2012-06-19 | Kevin Correia | R | 32 | L 7-2 | vs MIN | 13 | 144 | W | 5.1 | 4 | 0 | 0 | 0 | 1 | 2 | 97 | 36 | 61 | 63% | 3-6 | 4.14 | 1.30 |
| 2012-06-20 | Erik Bedard | L | 33 | W 1-2 | vs MIN | 14 | 179 | - | 6.0 | 4 | 1 | 1 | 0 | 2 | 7 | 97 | 33 | 64 | 66% | 4-7 | 4.13 | 1.42 |
| 2012-06-21 | James McDonald | R | 28 | L 9-1 | vs MIN | 14 | 61 | W | 9.0 | 6 | 1 | 1 | 0 | 0 | 5 | 114 | 41 | 73 | 64% | 6-3 | 2.20 | 0.96 |
| 2012-06-22 | A.J. Burnett | R | 35 | L 4-1 | vs DET | 12 | 321 | W | 6.0 | 2 | 0 | 0 | 0 | 3 | 4 | 96 | 38 | 58 | 60% | 8-2 | 3.24 | 1.24 |
| 2012-06-23 | Brad Lincoln | R | 27 | L 4-1 | vs DET | 5 | 22 | W | 6.0 | 2 | 1 | 1 | 1 | 1 | 7 | 78 | 19 | 59 | 76% | 4-2 | 3.48 | 1.23 |
| 2012-06-24 | Kevin Correia | R | 32 | W 2-3 | vs DET | 14 | 145 | - | 6.0 | 6 | 2 | 2 | 1 | 1 | 4 | 85 | 29 | 56 | 66% | 3-6 | 4.05 | 1.29 |
| 2012-06-25 | Jeff Karstens | R | 30 | L 3-8 | @ PHI | 4 | 80 | L | 5.0 | 11 | 7 | 6 | 1 | 0 | 4 | 94 | 34 | 60 | 64% | 0-2 | 6.35 | 1.65 |
| 2012-06-26 | Erik Bedard | L | 33 | L 4-5 | @ PHI | 15 | 180 | L | 6.0 | 8 | 4 | 4 | 1 | 2 | 3 | 90 | 29 | 61 | 68% | 4-8 | 4.27 | 1.44 |
| 2012-06-27 | James McDonald | R | 28 | W 11-7 | @ PHI | 15 | 62 | W | 5.2 | 6 | 4 | 4 | 2 | 2 | 3 | 105 | 41 | 64 | 61% | 7-3 | 2.44 | 0.98 |
| 2012-06-28 | A.J. Burnett | R | 35 | W 5-4 | @ PHI | 13 | 322 | W | 6.2 | 6 | 3 | 3 | 1 | 2 | 7 | 100 | 32 | 68 | 68% | 9-2 | 3.29 | 1.23 |
| 2012-06-29 | Kevin Correia | R | 32 | W 14-5 | @ SLN | 15 | 146 | W | 5.0 | 6 | 5 | 5 | 1 | 2 | 3 | 89 | 35 | 54 | 61% | 4-6 | 4.34 | 1.31 |
| 2012-06-30 | Jeff Karstens | R | 30 | W 7-3 | @ SLN | 5 | 81 | W | 7.0 | 4 | 2 | 2 | 0 | 2 | 7 | 96 | 34 | 62 | 65% | 1-2 | 5.25 | 1.42 |
| 2012-07-01 | Erik Bedard | L | 33 | L 4-5 | @ SLN | 16 | 181 | L | 4.2 | 8 | 5 | 5 | 2 | 2 | 5 | 99 | 36 | 63 | 64% | 4-9 | 4.55 | 1.47 |
| 2012-07-02 | James McDonald | R | 28 | L 11-2 | vs HOU | 16 | 63 | W | 7.0 | 4 | 2 | 2 | 1 | 5 | 4 | 110 | 46 | 64 | 58% | 8-3 | 2.45 | 1.00 |
| 2012-07-03 | A.J. Burnett | R | 35 | L 8-7 | vs HOU | 14 | 323 | - | 5.0 | 12 | 6 | 6 | 0 | 2 | 5 | 89 | 31 | 58 | 65% | 9-2 | 3.72 | 1.32 |
| 2012-07-04 | Kevin Correia | R | 32 | L 6-4 | vs HOU | 16 | 147 | W | 6.0 | 6 | 3 | 3 | 0 | 2 | 1 | 82 | 33 | 49 | 60% | 5-6 | 4.35 | 1.31 |
| 2012-07-05 | Jeff Karstens | R | 30 | L 2-0 | vs HOU | 6 | 82 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 8 | 89 | 27 | 62 | 70% | 2-2 | 3.94 | 1.22 |
| 2012-07-06 | Erik Bedard | L | 33 | W 5-6 | vs SFN | 17 | 182 | L | 3.2 | 4 | 5 | 4 | 1 | 3 | 1 | 73 | 30 | 43 | 59% | 4-10 | 4.81 | 1.50 |
| 2012-07-07 | James McDonald | R | 28 | L 3-1 | vs SFN | 17 | 64 | W | 7.0 | 4 | 1 | 1 | 0 | 0 | 10 | 103 | 29 | 74 | 72% | 9-3 | 2.37 | 0.97 |
| 2012-07-08 | A.J. Burnett | R | 36 | L 13-2 | vs SFN | 15 | 324 | W | 6.1 | 4 | 2 | 2 | 1 | 2 | 5 | 102 | 40 | 62 | 61% | 10-2 | 3.68 | 1.30 |
| 2012-07-13 | James McDonald | R | 28 | L 7-10 | @ MIL | 18 | 65 | - | 4.2 | 8 | 5 | 4 | 1 | 5 | 2 | 109 | 46 | 63 | 58% | 9-3 | 2.58 | 1.04 |
| 2012-07-14 | Kevin Correia | R | 32 | W 6-4 | @ MIL | 17 | 148 | W | 6.0 | 4 | 4 | 2 | 0 | 1 | 6 | 91 | 35 | 56 | 62% | 6-6 | 4.27 | 1.28 |
| 2012-07-15 | A.J. Burnett | R | 36 | L 1-4 | @ MIL | 16 | 325 | L | 7.0 | 9 | 4 | 4 | 0 | 0 | 7 | 82 | 27 | 55 | 67% | 10-3 | 3.78 | 1.30 |
| 2012-07-16 | Jeff Karstens | R | 30 | L 4-5 | @ COL | 7 | 83 | - | 7.0 | 6 | 4 | 4 | 0 | 2 | 4 | 105 | 35 | 70 | 67% | 2-2 | 4.15 | 1.21 |
| 2012-07-17 | Erik Bedard | L | 33 | W 6-2 | @ COL | 18 | 183 | W | 6.2 | 8 | 2 | 1 | 0 | 4 | 4 | 94 | 34 | 60 | 64% | 5-10 | 4.55 | 1.52 |
| 2012-07-18 | James McDonald | R | 28 | W 9-6 | @ COL | 19 | 66 | W | 5.0 | 9 | 6 | 6 | 2 | 4 | 2 | 107 | 48 | 59 | 55% | 10-3 | 2.93 | 1.11 |
| 2012-07-20 | Kevin Correia | R | 32 | L 4-3 | vs MIA | 18 | 149 | W | 5.0 | 8 | 3 | 3 | 1 | 0 | 5 | 93 | 27 | 66 | 71% | 7-6 | 4.32 | 1.29 |
| 2012-07-21 | A.J. Burnett | R | 36 | L 5-1 | vs MIA | 17 | 326 | W | 7.2 | 8 | 1 | 1 | 1 | 1 | 3 | 103 | 38 | 65 | 63% | 11-3 | 3.58 | 1.29 |
| 2012-07-22 | Jeff Karstens | R | 30 | L 3-0 | vs MIA | 8 | 84 | W | 7.0 | 5 | 0 | 0 | 0 | 2 | 3 | 90 | 30 | 60 | 67% | 3-2 | 3.52 | 1.17 |
| 2012-07-23 | Erik Bedard | L | 33 | W 0-2 | vs CHN | 19 | 184 | L | 7.0 | 2 | 1 | 1 | 0 | 2 | 11 | 112 | 46 | 66 | 59% | 5-11 | 4.32 | 1.45 |
| 2012-07-24 | James McDonald | R | 28 | W 1-5 | vs CHN | 20 | 67 | L | 6.0 | 5 | 5 | 5 | 2 | 3 | 6 | 86 | 30 | 56 | 65% | 10-4 | 3.14 | 1.12 |
| 2012-07-25 | Kevin Correia | R | 32 | L 3-2 | vs CHN | 19 | 150 | W | 6.0 | 4 | 2 | 2 | 1 | 2 | 4 | 78 | 29 | 49 | 63% | 8-6 | 4.25 | 1.28 |
| 2012-07-26 | A.J. Burnett | R | 36 | W 5-3 | @ HOU | 18 | 327 | W | 7.1 | 4 | 2 | 2 | 2 | 1 | 5 | 102 | 36 | 66 | 65% | 12-3 | 3.52 | 1.25 |
| 2012-07-27 | Jeff Karstens | R | 30 | W 6-5 | @ HOU | 9 | 85 | - | 5.0 | 6 | 4 | 4 | 2 | 3 | 7 | 91 | 34 | 57 | 63% | 3-2 | 3.88 | 1.24 |
| 2012-07-28 | Wandy Rodriguez | L | 34 | W 4-3 | @ HOU | 22 | 219 | - | 6.0 | 6 | 3 | 3 | 0 | 5 | 5 | 101 | 46 | 55 | 54% | 7-9 | 3.81 | 1.29 |
| 2012-07-29 | James McDonald | R | 28 | L 5-9 | @ HOU | 21 | 68 | L | 5.0 | 6 | 5 | 5 | 1 | 7 | 5 | 108 | 51 | 57 | 53% | 10-5 | 3.37 | 1.18 |
| 2012-07-30 | Erik Bedard | L | 33 | L 4-14 | @ CHN | 20 | 185 | L | 4.1 | 7 | 9 | 8 | 2 | 2 | 7 | 85 | 33 | 52 | 61% | 5-12 | 4.85 | 1.48 |
| 2012-07-31 | A.J. Burnett | R | 36 | W 5-0 | @ CHN | 19 | 328 | W | 9.0 | 1 | 0 | 0 | 0 | 2 | 8 | 115 | 38 | 77 | 67% | 13-3 | 3.27 | 1.19 |
| 2012-08-01 | Jeff Karstens | R | 30 | W 8-4 | @ CHN | 10 | 86 | W | 5.0 | 3 | 1 | 1 | 1 | 1 | 4 | 93 | 30 | 63 | 68% | 4-2 | 3.70 | 1.20 |
| 2012-08-03 | Wandy Rodriguez | L | 34 | L 0-3 | @ CIN | 23 | 220 | L | 7.0 | 7 | 3 | 3 | 2 | 0 | 4 | 87 | 24 | 63 | 72% | 7-10 | 3.81 | 1.28 |
| 2012-08-04 | James McDonald | R | 28 | L 4-5 | @ CIN | 22 | 69 | - | 6.0 | 7 | 4 | 3 | 0 | 1 | 7 | 98 | 37 | 61 | 62% | 10-5 | 3.42 | 1.18 |
| 2012-08-05 | A.J. Burnett | R | 36 | W 6-2 | @ CIN | 20 | 329 | W | 8.2 | 3 | 2 | 2 | 1 | 3 | 7 | 111 | 43 | 68 | 61% | 14-3 | 3.18 | 1.15 |
| 2012-08-06 | Erik Bedard | L | 33 | L 4-0 | vs ARI | 21 | 186 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 5 | 83 | 27 | 56 | 67% | 6-12 | 4.54 | 1.41 |
| 2012-08-07 | Jeff Karstens | R | 30 | W 4-10 | vs ARI | 11 | 87 | - | 6.0 | 8 | 3 | 3 | 1 | 0 | 4 | 100 | 29 | 71 | 71% | 4-2 | 3.77 | 1.21 |
| 2012-08-08 | Kevin Correia | R | 32 | L 7-6 | vs ARI | 20 | 151 | W | 6.0 | 6 | 4 | 3 | 0 | 3 | 5 | 90 | 30 | 60 | 67% | 9-6 | 4.50 | 1.32 |
| 2012-08-09 | Wandy Rodriguez | L | 34 | W 3-6 | vs ARI | 24 | 221 | L | 6.0 | 7 | 4 | 4 | 2 | 2 | 2 | 90 | 35 | 55 | 61% | 7-11 | 3.90 | 1.29 |
| 2012-08-10 | James McDonald | R | 28 | W 8-9 | vs SDN | 23 | 70 | - | 4.1 | 7 | 7 | 7 | 2 | 1 | 4 | 86 | 31 | 55 | 64% | 10-5 | 3.77 | 1.21 |
| 2012-08-11 | A.J. Burnett | R | 36 | W 0-5 | vs SDN | 21 | 330 | L | 5.2 | 9 | 5 | 4 | 2 | 2 | 10 | 101 | 36 | 65 | 64% | 14-4 | 3.33 | 1.19 |
| 2012-08-12 | Erik Bedard | L | 33 | L 11-5 | vs SDN | 22 | 187 | W | 5.0 | 5 | 5 | 3 | 1 | 4 | 6 | 104 | 40 | 64 | 62% | 7-12 | 4.58 | 1.42 |
| 2012-08-13 | Jeff Karstens | R | 30 | W 4-5 | vs LAN | 12 | 88 | L | 7.0 | 7 | 4 | 4 | 1 | 1 | 4 | 100 | 39 | 61 | 61% | 4-3 | 3.91 | 1.20 |
| 2012-08-14 | Kevin Correia | R | 32 | W 0-11 | vs LAN | 21 | 152 | L | 6.0 | 7 | 6 | 5 | 0 | 1 | 3 | 73 | 24 | 49 | 67% | 9-7 | 4.65 | 1.32 |
| 2012-08-15 | Wandy Rodriguez | L | 34 | W 3-9 | vs LAN | 25 | 222 | L | 5.2 | 10 | 5 | 5 | 0 | 1 | 1 | 104 | 32 | 72 | 69% | 7-12 | 4.06 | 1.32 |
| 2012-08-16 | A.J. Burnett | R | 36 | L 10-6 | vs LAN | 22 | 331 | W | 6.2 | 7 | 6 | 6 | 2 | 1 | 7 | 93 | 30 | 63 | 68% | 15-4 | 3.54 | 1.19 |
| 2012-08-17 | James McDonald | R | 28 | W 2-1 | @ SLN | 24 | 71 | W | 6.0 | 2 | 0 | 0 | 0 | 3 | 7 | 89 | 34 | 55 | 62% | 11-5 | 3.61 | 1.19 |
| 2012-08-18 | Erik Bedard | L | 33 | L 4-5 | @ SLN | 23 | 188 | L | 4.2 | 9 | 5 | 5 | 0 | 3 | 4 | 80 | 30 | 50 | 63% | 7-13 | 4.76 | 1.46 |
| 2012-08-19 | Jeff Karstens | R | 30 | W 6-3 | @ SLN | 13 | 89 | - | 7.0 | 2 | 2 | 2 | 0 | 1 | 4 | 91 | 24 | 67 | 74% | 4-3 | 3.79 | 1.13 |
| 2012-08-20 | Kevin Correia | R | 32 | L 1-3 | @ SDN | 22 | 153 | L | 4.1 | 7 | 3 | 2 | 0 | 1 | 2 | 74 | 26 | 48 | 65% | 9-8 | 4.53 | 1.33 |
| 2012-08-21 | A.J. Burnett | R | 36 | L 5-7 | @ SDN | 23 | 332 | - | 6.1 | 12 | 4 | 4 | 0 | 5 | 7 | 110 | 37 | 73 | 66% | 15-4 | 3.64 | 1.25 |
| 2012-08-22 | James McDonald | R | 28 | L 2-4 | @ SDN | 25 | 72 | L | 5.0 | 5 | 4 | 4 | 0 | 5 | 2 | 108 | 43 | 65 | 60% | 11-6 | 3.73 | 1.22 |
| 2012-08-24 | Wandy Rodriguez | L | 34 | W 5-6 | vs MIL | 26 | 223 | L | 6.2 | 6 | 3 | 3 | 0 | 4 | 3 | 99 | 35 | 64 | 65% | 8-13 | 4.01 | 1.32 |
| 2012-08-25 | Jeff Karstens | R | 30 | L 4-0 | vs MIL | 14 | 90 | W | 7.0 | 7 | 0 | 0 | 0 | 0 | 4 | 83 | 21 | 62 | 75% | 5-3 | 3.47 | 1.12 |
| 2012-08-26 | Erik Bedard | L | 33 | W 0-7 | vs MIL | 24 | 189 | L | 4.2 | 6 | 6 | 6 | 2 | 2 | 3 | 82 | 27 | 55 | 67% | 7-14 | 5.00 | 1.47 |
| 2012-08-27 | A.J. Burnett | R | 36 | W 3-4 | vs SLN | 24 | 333 | L | 5.2 | 7 | 4 | 3 | 1 | 1 | 3 | 92 | 34 | 58 | 63% | 15-5 | 3.67 | 1.25 |
| 2012-08-28 | James McDonald | R | 28 | L 9-0 | vs SLN | 26 | 73 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 6 | 96 | 31 | 65 | 68% | 12-6 | 3.57 | 1.18 |
| 2012-08-29 | Wandy Rodriguez | L | 34 | L 5-0 | vs SLN | 27 | 224 | W | 6.0 | 3 | 0 | 0 | 0 | 3 | 3 | 96 | 36 | 60 | 63% | 9-13 | 3.86 | 1.31 |
| 2012-08-31 | Jeff Karstens | R | 30 | L 3-9 | @ MIL | 15 | 91 | L | 0.1 | 5 | 4 | 4 | 1 | 0 | 1 | 20 | 5 | 15 | 75% | 5-4 | 3.90 | 1.18 |
| 2012-09-01 | A.J. Burnett | R | 36 | L 2-3 | @ MIL | 25 | 334 | - | 6.2 | 2 | 2 | 2 | 0 | 4 | 9 | 106 | 47 | 59 | 56% | 15-5 | 3.62 | 1.24 |
| 2012-09-02 | James McDonald | R | 28 | L 8-12 | @ MIL | 27 | 74 | L | 2.2 | 6 | 8 | 7 | 4 | 1 | 6 | 63 | 23 | 40 | 63% | 12-7 | 3.89 | 1.20 |
| 2012-09-03 | Jeff Locke | L | 25 | W 1-5 | vs HOU | 1 | 5 | L | 5.0 | 7 | 5 | 5 | 1 | 1 | 6 | 76 | 18 | 58 | 76% | 0-1 | 5.00 | 1.00 |
| 2012-09-04 | Wandy Rodriguez | L | 34 | L 6-2 | vs HOU | 28 | 225 | W | 7.0 | 4 | 0 | 0 | 0 | 1 | 7 | 88 | 29 | 59 | 67% | 10-13 | 3.71 | 1.28 |
| 2012-09-05 | Kevin Correia | R | 32 | L 6-3 | vs HOU | 23 | 154 | W | 6.0 | 4 | 1 | 1 | 0 | 1 | 1 | 67 | 25 | 42 | 63% | 10-8 | 4.28 | 1.32 |
| 2012-09-07 | A.J. Burnett | R | 36 | W 2-12 | vs CHN | 26 | 335 | L | 5.0 | 8 | 7 | 3 | 0 | 1 | 4 | 92 | 27 | 65 | 71% | 15-6 | 3.67 | 1.25 |
| 2012-09-08 | James McDonald | R | 28 | W 3-4 | vs CHN | 28 | 75 | - | 5.2 | 7 | 3 | 3 | 1 | 2 | 2 | 90 | 34 | 56 | 62% | 12-7 | 3.93 | 1.22 |
| 2012-09-09 | Jeff Locke | L | 25 | W 2-4 | vs CHN | 2 | 6 | - | 6.0 | 7 | 2 | 2 | 2 | 0 | 6 | 88 | 29 | 59 | 67% | 0-1 | 4.20 | 1.07 |
| 2012-09-10 | Wandy Rodriguez | L | 34 | L 3-4 | @ CIN | 29 | 226 | - | 6.2 | 3 | 3 | 3 | 1 | 1 | 5 | 89 | 24 | 65 | 73% | 10-13 | 3.72 | 1.26 |
| 2012-09-11 | Kevin Correia | R | 32 | L 3-5 | @ CIN | 24 | 155 | L | 6.0 | 7 | 4 | 3 | 1 | 3 | 2 | 95 | 37 | 58 | 61% | 10-9 | 4.29 | 1.33 |
| 2012-09-12 | A.J. Burnett | R | 36 | L 1-2 | @ CIN | 27 | 336 | L | 6.0 | 5 | 2 | 2 | 0 | 2 | 8 | 103 | 41 | 62 | 60% | 15-7 | 3.65 | 1.25 |
| 2012-09-14 | James McDonald | R | 28 | L 4-7 | @ CHN | 29 | 76 | L | 3.2 | 5 | 4 | 4 | 0 | 4 | 2 | 81 | 40 | 41 | 51% | 12-8 | 4.05 | 1.25 |
| 2012-09-15 | Wandy Rodriguez | L | 34 | W 7-6 | @ CHN | 30 | 227 | W | 6.0 | 9 | 3 | 1 | 0 | 1 | 4 | 98 | 32 | 66 | 67% | 11-13 | 3.65 | 1.27 |
| 2012-09-16 | Jeff Locke | L | 25 | L 9-13 | @ CHN | 3 | 7 | - | 4.1 | 7 | 5 | 5 | 2 | 1 | 2 | 72 | 27 | 45 | 63% | 0-1 | 5.40 | 1.20 |
| 2012-09-17 | Kevin Correia | R | 32 | W 3-0 | @ CHN | 25 | 156 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 6 | 86 | 28 | 58 | 67% | 11-9 | 4.09 | 1.29 |
| 2012-09-18 | A.J. Burnett | R | 36 | W 0-6 | vs MIL | 28 | 337 | L | 6.0 | 7 | 2 | 2 | 0 | 2 | 4 | 94 | 41 | 53 | 56% | 15-8 | 3.63 | 1.26 |
| 2012-09-19 | Kyle McPherson | R | 25 | W 1-3 | vs MIL | 1 | 1 | L | 4.1 | 7 | 2 | 2 | 1 | 1 | 2 | 71 | 25 | 46 | 65% | 0-1 | 2.25 | 1.19 |
| 2012-09-20 | Wandy Rodriguez | L | 34 | W 7-9 | vs MIL | 31 | 228 | - | 4.0 | 5 | 4 | 4 | 1 | 2 | 3 | 79 | 27 | 52 | 66% | 11-13 | 3.76 | 1.28 |
| 2012-09-21 | Jeff Locke | L | 25 | L 1-7 | @ HOU | 4 | 8 | L | 5.0 | 3 | 3 | 3 | 1 | 3 | 8 | 84 | 33 | 51 | 61% | 0-2 | 5.40 | 1.20 |
| 2012-09-22 | Kevin Correia | R | 32 | L 1-4 | @ HOU | 26 | 157 | L | 6.0 | 7 | 4 | 3 | 1 | 1 | 9 | 98 | 40 | 58 | 59% | 11-10 | 4.11 | 1.29 |
| 2012-09-23 | A.J. Burnett | R | 36 | W 8-1 | @ HOU | 29 | 338 | W | 8.0 | 4 | 1 | 1 | 1 | 1 | 11 | 110 | 36 | 74 | 67% | 16-8 | 3.52 | 1.23 |
| 2012-09-24 | Kyle McPherson | R | 25 | L 2-6 | @ NYN | 2 | 2 | L | 4.1 | 4 | 4 | 4 | 1 | 3 | 3 | 82 | 37 | 45 | 55% | 0-2 | 3.60 | 1.30 |
| 2012-09-25 | Wandy Rodriguez | L | 34 | W 10-6 | @ NYN | 32 | 229 | W | 6.0 | 4 | 3 | 3 | 2 | 2 | 3 | 106 | 32 | 74 | 70% | 12-13 | 3.78 | 1.27 |
| 2012-09-26 | Jeff Locke | L | 25 | L 0-6 | @ NYN | 5 | 9 | L | 3.2 | 9 | 5 | 5 | 0 | 1 | 5 | 71 | 24 | 47 | 66% | 0-3 | 6.43 | 1.43 |
| 2012-09-27 | Kevin Correia | R | 32 | L 5-6 | @ NYN | 27 | 158 | L | 4.1 | 7 | 6 | 6 | 2 | 1 | 2 | 78 | 28 | 50 | 64% | 11-11 | 4.34 | 1.31 |
| 2012-09-28 | A.J. Burnett | R | 36 | W 0-1 | vs CIN | 30 | 339 | L | 8.0 | 7 | 1 | 1 | 0 | 1 | 5 | 106 | 43 | 63 | 59% | 16-9 | 3.43 | 1.22 |
| 2012-09-29 | Kyle McPherson | R | 25 | L 2-1 | vs CIN | 3 | 3 | - | 6.0 | 4 | 0 | 0 | 0 | 1 | 5 | 93 | 34 | 59 | 63% | 0-2 | 2.77 | 1.19 |
| 2012-09-30 | Wandy Rodriguez | L | 34 | W 3-4 | vs CIN | 33 | 230 | - | 6.0 | 6 | 2 | 2 | 0 | 1 | 7 | 102 | 28 | 74 | 73% | 12-13 | 3.76 | 1.27 |
| 2012-10-01 | Jeff Locke | L | 25 | L 2-1 | vs ATL | 6 | 10 | W | 6.0 | 2 | 1 | 1 | 0 | 5 | 6 | 103 | 42 | 61 | 59% | 1-3 | 5.56 | 1.38 |
| 2012-10-02 | Kevin Correia | R | 32 | L 5-1 | vs ATL | 28 | 159 | W | 6.2 | 6 | 1 | 1 | 0 | 1 | 5 | 97 | 36 | 61 | 63% | 12-11 | 4.21 | 1.30 |
| 2012-10-03 | A.J. Burnett | R | 36 | W 0-4 | vs ATL | 31 | 340 | L | 5.2 | 8 | 4 | 4 | 0 | 2 | 3 | 87 | 32 | 55 | 63% | 16-10 | 3.52 | 1.24 |