| West | W | L | Pct | GB |
| Texas | 93 | 69 | .574 | -- |
| LA Angels | 89 | 73 | .549 | 4.0 |
| Oakland | 64 | 68 | .485 | 15.0 |
| Seattle | 75 | 87 | .463 | 18.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-03-28 | Brandon McCarthy | R | 29 | W 1-3 | vs SEA | 1 | 82 | - | 7.0 | 6 | 1 | 1 | 1 | 0 | 3 | 82 | 24 | 58 | 71% | 0-0 | 1.29 | 0.86 |
| 2012-03-29 | Bartolo Colon | R | 37 | L 4-1 | vs SEA | 1 | 352 | W | 8.0 | 3 | 1 | 1 | 1 | 1 | 6 | 86 | 23 | 63 | 73% | 1-0 | 1.13 | 0.50 |
| 2012-04-06 | Brandon McCarthy | R | 29 | W 3-7 | vs SEA | 2 | 83 | L | 5.0 | 7 | 5 | 2 | 0 | 2 | 3 | 95 | 37 | 58 | 61% | 0-1 | 2.25 | 1.25 |
| 2012-04-07 | Bartolo Colon | R | 37 | W 7-8 | vs SEA | 2 | 353 | L | 4.1 | 10 | 7 | 7 | 0 | 0 | 3 | 77 | 27 | 50 | 65% | 1-1 | 6.00 | 1.17 |
| 2012-04-09 | Tommy Milone | L | 25 | L 1-0 | vs KCA | 1 | 6 | W | 8.0 | 3 | 0 | 0 | 0 | 3 | 0 | 93 | 41 | 52 | 56% | 1-0 | 0.00 | 0.75 |
| 2012-04-10 | Graham Godfrey | R | 28 | W 0-3 | vs KCA | 1 | 5 | L | 6.0 | 6 | 2 | 2 | 0 | 1 | 1 | 83 | 31 | 52 | 63% | 0-1 | 3.00 | 1.17 |
| 2012-04-11 | Brandon McCarthy | R | 29 | L 5-4 | vs KCA | 3 | 84 | - | 6.0 | 6 | 2 | 2 | 1 | 2 | 4 | 102 | 35 | 67 | 66% | 0-1 | 2.50 | 1.28 |
| 2012-04-13 | Bartolo Colon | R | 37 | W 4-0 | @ SEA | 3 | 354 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 5 | 104 | 34 | 70 | 67% | 2-1 | 3.79 | 0.95 |
| 2012-04-14 | Tommy Milone | L | 25 | L 0-4 | @ SEA | 2 | 7 | L | 6.0 | 4 | 4 | 4 | 1 | 2 | 5 | 89 | 38 | 51 | 57% | 1-1 | 2.57 | 0.86 |
| 2012-04-15 | Graham Godfrey | R | 28 | L 3-5 | @ SEA | 2 | 6 | L | 5.0 | 6 | 5 | 3 | 2 | 1 | 3 | 95 | 34 | 61 | 64% | 0-2 | 4.09 | 1.27 |
| 2012-04-16 | Brandon McCarthy | R | 29 | L 0-6 | @ ANA | 4 | 85 | L | 7.0 | 11 | 5 | 5 | 1 | 0 | 4 | 99 | 31 | 68 | 69% | 0-2 | 3.60 | 1.36 |
| 2012-04-17 | Tyson Ross | R | 25 | W 5-3 | @ ANA | 1 | 9 | - | 6.0 | 7 | 2 | 2 | 0 | 0 | 3 | 95 | 32 | 63 | 66% | 0-0 | 3.00 | 1.17 |
| 2012-04-18 | Bartolo Colon | R | 37 | W 6-0 | @ ANA | 4 | 355 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 5 | 108 | 26 | 82 | 76% | 3-1 | 2.67 | 0.81 |
| 2012-04-19 | Tommy Milone | L | 25 | W 4-2 | @ ANA | 3 | 8 | W | 5.0 | 7 | 2 | 2 | 0 | 1 | 3 | 93 | 27 | 66 | 71% | 2-1 | 2.84 | 1.05 |
| 2012-04-20 | Graham Godfrey | R | 28 | W 3-4 | vs CLE | 3 | 7 | L | 5.0 | 3 | 4 | 4 | 0 | 5 | 3 | 93 | 40 | 53 | 57% | 0-3 | 5.06 | 1.38 |
| 2012-04-21 | Brandon McCarthy | R | 29 | W 1-5 | vs CLE | 5 | 86 | L | 7.0 | 10 | 2 | 2 | 0 | 3 | 4 | 112 | 47 | 65 | 58% | 0-3 | 3.38 | 1.47 |
| 2012-04-22 | Tyson Ross | R | 25 | L 5-1 | vs CLE | 2 | 10 | W | 6.2 | 4 | 1 | 1 | 0 | 5 | 4 | 100 | 43 | 57 | 57% | 1-0 | 2.08 | 1.23 |
| 2012-04-23 | Bartolo Colon | R | 37 | W 0-4 | vs CHA | 5 | 356 | L | 7.0 | 7 | 2 | 2 | 2 | 3 | 2 | 89 | 26 | 63 | 71% | 3-2 | 2.65 | 0.94 |
| 2012-04-24 | Tommy Milone | L | 25 | L 2-0 | vs CHA | 4 | 9 | W | 8.0 | 3 | 0 | 0 | 0 | 0 | 5 | 96 | 30 | 66 | 69% | 3-1 | 2.00 | 0.85 |
| 2012-04-25 | Jarrod Parker | R | 23 | L 5-4 | vs CHA | 1 | 2 | - | 6.1 | 7 | 1 | 1 | 0 | 1 | 5 | 97 | 37 | 60 | 62% | 0-0 | 1.50 | 1.33 |
| 2012-04-27 | Brandon McCarthy | R | 29 | W 5-2 | @ BAL | 6 | 87 | W | 7.0 | 5 | 2 | 2 | 0 | 3 | 4 | 96 | 31 | 65 | 68% | 1-3 | 3.23 | 1.41 |
| 2012-04-28 | Tyson Ross | R | 25 | L 1-10 | @ BAL | 3 | 11 | L | 4.0 | 11 | 9 | 9 | 0 | 1 | 1 | 72 | 25 | 47 | 65% | 1-1 | 6.35 | 1.65 |
| 2012-04-29 | Bartolo Colon | R | 37 | L 2-5 | @ BAL | 6 | 357 | - | 8.1 | 7 | 2 | 2 | 0 | 1 | 5 | 103 | 34 | 69 | 67% | 3-2 | 2.51 | 0.93 |
| 2012-04-30 | Tommy Milone | L | 25 | L 6-11 | @ BOS | 5 | 10 | L | 4.2 | 8 | 8 | 7 | 3 | 1 | 5 | 101 | 30 | 71 | 70% | 3-2 | 3.66 | 1.00 |
| 2012-05-01 | Jarrod Parker | R | 23 | W 5-3 | @ BOS | 2 | 3 | W | 6.2 | 4 | 1 | 1 | 0 | 2 | 4 | 100 | 40 | 60 | 60% | 1-0 | 1.38 | 1.08 |
| 2012-05-02 | Brandon McCarthy | R | 29 | W 4-2 | @ BOS | 7 | 88 | W | 6.2 | 5 | 1 | 1 | 0 | 3 | 4 | 116 | 45 | 71 | 61% | 2-3 | 2.93 | 1.37 |
| 2012-05-04 | Tyson Ross | R | 25 | L 2-7 | @ TBA | 4 | 12 | L | 3.1 | 9 | 7 | 7 | 1 | 2 | 2 | 82 | 32 | 50 | 61% | 1-2 | 8.55 | 1.95 |
| 2012-05-05 | Bartolo Colon | R | 37 | W 4-3 | @ TBA | 7 | 358 | - | 5.0 | 8 | 3 | 3 | 3 | 2 | 2 | 83 | 26 | 57 | 69% | 3-2 | 2.81 | 1.04 |
| 2012-05-06 | Tommy Milone | L | 25 | W 9-5 | @ TBA | 6 | 11 | W | 5.0 | 5 | 5 | 5 | 1 | 4 | 1 | 99 | 40 | 59 | 60% | 4-2 | 4.38 | 1.11 |
| 2012-05-08 | Jarrod Parker | R | 23 | L 7-3 | vs TOR | 3 | 4 | - | 7.0 | 4 | 2 | 2 | 1 | 5 | 3 | 104 | 49 | 55 | 53% | 1-0 | 1.80 | 1.15 |
| 2012-05-09 | Tyson Ross | R | 25 | W 2-5 | vs TOR | 5 | 13 | L | 5.2 | 5 | 3 | 3 | 1 | 3 | 3 | 87 | 33 | 54 | 62% | 1-3 | 7.62 | 1.81 |
| 2012-05-10 | Bartolo Colon | R | 37 | W 6-10 | vs DET | 8 | 359 | L | 2.1 | 9 | 8 | 7 | 1 | 0 | 0 | 44 | 13 | 31 | 70% | 3-3 | 3.96 | 1.18 |
| 2012-05-11 | Tommy Milone | L | 25 | L 11-4 | vs DET | 7 | 12 | W | 7.0 | 5 | 2 | 1 | 0 | 1 | 6 | 97 | 31 | 66 | 68% | 5-2 | 3.89 | 1.07 |
| 2012-05-12 | Brandon McCarthy | R | 29 | L 3-1 | vs DET | 8 | 89 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 10 | 87 | 25 | 62 | 71% | 3-3 | 2.55 | 1.26 |
| 2012-05-13 | Jarrod Parker | R | 23 | W 1-3 | vs DET | 4 | 5 | L | 5.2 | 6 | 2 | 2 | 0 | 4 | 5 | 112 | 51 | 61 | 54% | 1-1 | 2.08 | 1.27 |
| 2012-05-14 | Tyson Ross | R | 25 | W 5-0 | @ ANA | 6 | 14 | W | 6.0 | 5 | 0 | 0 | 0 | 1 | 2 | 98 | 38 | 60 | 61% | 2-3 | 6.19 | 1.66 |
| 2012-05-15 | Bartolo Colon | R | 37 | L 0-4 | @ ANA | 9 | 360 | L | 6.2 | 12 | 4 | 4 | 1 | 0 | 3 | 89 | 28 | 61 | 69% | 3-4 | 4.11 | 1.25 |
| 2012-05-16 | Tommy Milone | L | 25 | L 1-4 | @ TEX | 8 | 13 | L | 7.0 | 9 | 4 | 4 | 1 | 1 | 4 | 100 | 36 | 64 | 64% | 5-3 | 4.06 | 1.12 |
| 2012-05-17 | Brandon McCarthy | R | 29 | W 5-4 | @ TEX | 9 | 90 | - | 5.1 | 8 | 4 | 4 | 2 | 3 | 4 | 94 | 35 | 59 | 63% | 3-3 | 2.95 | 1.34 |
| 2012-05-18 | Jarrod Parker | R | 23 | L 6-8 | @ SFN | 5 | 6 | L | 2.0 | 4 | 6 | 6 | 0 | 4 | 0 | 66 | 35 | 31 | 47% | 1-2 | 3.86 | 1.46 |
| 2012-05-19 | Tyson Ross | R | 25 | L 0-4 | @ SFN | 7 | 15 | L | 6.0 | 7 | 2 | 2 | 0 | 4 | 4 | 107 | 47 | 60 | 56% | 2-4 | 5.68 | 1.68 |
| 2012-05-20 | Bartolo Colon | R | 37 | W 6-2 | @ SFN | 10 | 361 | W | 5.0 | 6 | 2 | 2 | 0 | 2 | 7 | 90 | 34 | 56 | 62% | 4-4 | 4.06 | 1.27 |
| 2012-05-21 | Tommy Milone | L | 25 | L 2-1 | vs ANA | 9 | 14 | W | 7.0 | 5 | 1 | 1 | 0 | 1 | 3 | 105 | 35 | 70 | 67% | 6-3 | 3.72 | 1.09 |
| 2012-05-22 | Graham Godfrey | R | 28 | W 0-5 | vs ANA | 4 | 8 | L | 3.0 | 6 | 4 | 4 | 1 | 3 | 2 | 53 | 29 | 24 | 45% | 0-4 | 6.16 | 1.63 |
| 2012-05-23 | Jarrod Parker | R | 23 | W 1-3 | vs ANA | 6 | 7 | - | 7.0 | 5 | 1 | 1 | 0 | 1 | 8 | 95 | 29 | 66 | 69% | 1-2 | 3.34 | 1.34 |
| 2012-05-25 | Tyson Ross | R | 25 | W 3-6 | vs NYA | 8 | 16 | L | 4.1 | 12 | 6 | 6 | 3 | 2 | 3 | 96 | 35 | 61 | 64% | 2-5 | 6.43 | 1.86 |
| 2012-05-26 | Bartolo Colon | R | 37 | W 2-9 | vs NYA | 11 | 362 | L | 6.0 | 9 | 6 | 6 | 2 | 0 | 3 | 73 | 18 | 55 | 75% | 4-5 | 4.50 | 1.29 |
| 2012-05-27 | Tommy Milone | L | 25 | W 0-2 | vs NYA | 10 | 15 | L | 6.2 | 8 | 2 | 2 | 1 | 2 | 3 | 108 | 37 | 71 | 66% | 6-4 | 3.66 | 1.14 |
| 2012-05-28 | Travis Blackley | L | 30 | L 4-5 | @ MIN | 1 | 9 | - | 5.0 | 3 | 1 | 1 | 1 | 1 | 3 | 71 | 29 | 42 | 59% | 0-0 | 3.38 | 1.06 |
| 2012-05-29 | Jarrod Parker | R | 24 | L 2-3 | @ MIN | 7 | 8 | - | 6.0 | 4 | 0 | 0 | 0 | 4 | 4 | 105 | 46 | 59 | 56% | 1-2 | 2.85 | 1.34 |
| 2012-05-30 | Tyson Ross | R | 25 | L 0-4 | @ MIN | 9 | 17 | L | 5.0 | 6 | 4 | 4 | 1 | 3 | 1 | 80 | 37 | 43 | 54% | 2-6 | 6.51 | 1.85 |
| 2012-06-01 | Bartolo Colon | R | 37 | L 0-2 | @ KCA | 12 | 363 | L | 7.0 | 8 | 2 | 2 | 0 | 2 | 3 | 101 | 34 | 67 | 66% | 4-6 | 4.32 | 1.31 |
| 2012-06-02 | Brandon McCarthy | R | 29 | W 9-3 | @ KCA | 10 | 91 | W | 6.0 | 8 | 2 | 2 | 0 | 2 | 2 | 72 | 18 | 54 | 75% | 4-3 | 2.95 | 1.38 |
| 2012-06-03 | Tommy Milone | L | 25 | L 0-2 | @ KCA | 11 | 16 | L | 7.0 | 8 | 2 | 2 | 1 | 1 | 6 | 110 | 36 | 74 | 67% | 6-5 | 3.55 | 1.15 |
| 2012-06-04 | Jarrod Parker | R | 24 | L 12-1 | vs TEX | 8 | 9 | W | 8.0 | 1 | 0 | 0 | 0 | 3 | 6 | 106 | 41 | 65 | 61% | 2-2 | 2.39 | 1.20 |
| 2012-06-05 | Travis Blackley | L | 30 | W 3-6 | vs TEX | 2 | 10 | L | 4.2 | 7 | 5 | 5 | 0 | 2 | 5 | 93 | 38 | 55 | 59% | 0-1 | 4.71 | 1.24 |
| 2012-06-06 | Bartolo Colon | R | 37 | L 2-0 | vs TEX | 13 | 364 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 5 | 99 | 23 | 76 | 77% | 5-6 | 3.90 | 1.25 |
| 2012-06-07 | Brandon McCarthy | R | 29 | L 7-1 | vs TEX | 11 | 92 | W | 7.0 | 3 | 1 | 1 | 0 | 0 | 5 | 87 | 29 | 58 | 67% | 5-3 | 2.79 | 1.28 |
| 2012-06-08 | Tommy Milone | L | 25 | L 8-9 | @ ARI | 12 | 17 | - | 5.0 | 9 | 4 | 4 | 2 | 2 | 5 | 91 | 30 | 61 | 67% | 6-5 | 3.79 | 1.22 |
| 2012-06-09 | Jarrod Parker | R | 24 | L 3-8 | @ ARI | 9 | 10 | L | 5.0 | 8 | 6 | 6 | 1 | 5 | 4 | 108 | 51 | 57 | 53% | 2-3 | 3.17 | 1.33 |
| 2012-06-10 | Travis Blackley | L | 30 | L 3-4 | @ ARI | 3 | 11 | L | 4.2 | 6 | 4 | 3 | 0 | 3 | 2 | 101 | 42 | 59 | 58% | 0-2 | 5.04 | 1.40 |
| 2012-06-12 | Bartolo Colon | R | 37 | W 8-5 | @ COL | 14 | 365 | W | 5.0 | 9 | 5 | 5 | 2 | 3 | 4 | 107 | 43 | 64 | 60% | 6-6 | 4.19 | 1.32 |
| 2012-06-13 | Tommy Milone | L | 25 | W 10-8 | @ COL | 13 | 18 | - | 4.0 | 7 | 8 | 8 | 3 | 4 | 4 | 89 | 37 | 52 | 58% | 6-5 | 4.50 | 1.30 |
| 2012-06-14 | Jarrod Parker | R | 24 | W 8-2 | @ COL | 10 | 11 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 6 | 90 | 29 | 61 | 68% | 3-3 | 2.80 | 1.25 |
| 2012-06-15 | Travis Blackley | L | 30 | L 10-2 | vs SDN | 4 | 12 | W | 6.0 | 5 | 2 | 2 | 0 | 2 | 3 | 99 | 41 | 58 | 59% | 1-2 | 4.65 | 1.35 |
| 2012-06-16 | Tyson Ross | R | 25 | L 6-4 | vs SDN | 10 | 18 | - | 6.0 | 1 | 2 | 2 | 1 | 4 | 6 | 94 | 45 | 49 | 52% | 2-6 | 6.11 | 1.74 |
| 2012-06-17 | Bartolo Colon | R | 37 | W 1-2 | vs SDN | 15 | 366 | L | 2.0 | 1 | 1 | 1 | 0 | 0 | 2 | 29 | 7 | 22 | 76% | 6-7 | 4.20 | 1.30 |
| 2012-06-19 | Brandon McCarthy | R | 29 | L 3-0 | vs LAN | 12 | 93 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 5 | 81 | 25 | 56 | 69% | 6-3 | 2.54 | 1.21 |
| 2012-06-20 | Tommy Milone | L | 25 | L 4-1 | vs LAN | 14 | 19 | W | 9.0 | 3 | 1 | 1 | 0 | 1 | 2 | 112 | 39 | 73 | 65% | 7-5 | 4.15 | 1.21 |
| 2012-06-21 | Travis Blackley | L | 30 | L 4-1 | vs LAN | 5 | 13 | - | 8.0 | 3 | 1 | 1 | 0 | 0 | 6 | 83 | 20 | 63 | 76% | 1-2 | 3.92 | 1.15 |
| 2012-06-22 | Jarrod Parker | R | 24 | W 4-5 | vs SFN | 11 | 12 | - | 6.0 | 4 | 1 | 1 | 0 | 2 | 4 | 97 | 39 | 58 | 60% | 3-3 | 2.69 | 1.22 |
| 2012-06-23 | Tyson Ross | R | 25 | W 8-9 | vs SFN | 11 | 19 | L | 5.1 | 4 | 5 | 3 | 0 | 4 | 3 | 93 | 37 | 56 | 60% | 2-7 | 6.05 | 1.72 |
| 2012-06-24 | A.J. Griffin | R | 24 | L 4-2 | vs SFN | 1 | 1 | - | 6.0 | 3 | 2 | 2 | 1 | 1 | 4 | 104 | 31 | 73 | 70% | 0-0 | 3.00 | 0.67 |
| 2012-06-25 | Tommy Milone | L | 25 | W 1-0 | @ SEA | 15 | 20 | W | 7.0 | 7 | 0 | 0 | 0 | 0 | 5 | 110 | 32 | 78 | 71% | 8-5 | 3.84 | 1.20 |
| 2012-06-26 | Travis Blackley | L | 30 | L 2-3 | @ SEA | 6 | 14 | - | 7.0 | 5 | 2 | 2 | 0 | 1 | 3 | 88 | 36 | 52 | 59% | 1-2 | 3.72 | 1.11 |
| 2012-06-27 | Jarrod Parker | R | 24 | W 2-1 | @ SEA | 12 | 13 | W | 7.0 | 3 | 1 | 1 | 1 | 4 | 9 | 109 | 43 | 66 | 61% | 4-3 | 2.55 | 1.20 |
| 2012-06-28 | Tyson Ross | R | 25 | L 6-7 | @ TEX | 12 | 20 | L | 4.0 | 8 | 5 | 5 | 0 | 1 | 3 | 86 | 31 | 55 | 64% | 2-8 | 6.39 | 1.76 |
| 2012-06-29 | A.J. Griffin | R | 24 | L 3-4 | @ TEX | 2 | 2 | - | 6.0 | 2 | 0 | 0 | 0 | 2 | 4 | 109 | 42 | 67 | 61% | 0-0 | 1.50 | 0.67 |
| 2012-06-30 | Tommy Milone | L | 25 | L 2-7 | @ TEX | 16 | 21 | L | 5.0 | 6 | 6 | 1 | 2 | 0 | 6 | 97 | 33 | 64 | 66% | 8-6 | 3.74 | 1.20 |
| 2012-07-01 | Travis Blackley | L | 30 | W 3-1 | @ TEX | 7 | 15 | W | 7.0 | 7 | 1 | 1 | 0 | 0 | 3 | 97 | 30 | 67 | 69% | 2-2 | 3.40 | 1.09 |
| 2012-07-02 | Jarrod Parker | R | 24 | L 6-1 | vs BOS | 13 | 14 | W | 6.2 | 6 | 1 | 1 | 0 | 3 | 3 | 102 | 38 | 64 | 63% | 5-3 | 2.48 | 1.23 |
| 2012-07-03 | Bartolo Colon | R | 37 | L 3-2 | vs BOS | 16 | 367 | - | 6.0 | 5 | 2 | 1 | 1 | 1 | 3 | 86 | 32 | 54 | 63% | 6-7 | 4.03 | 1.28 |
| 2012-07-04 | A.J. Griffin | R | 24 | L 3-2 | vs BOS | 3 | 3 | - | 6.0 | 4 | 2 | 2 | 1 | 2 | 3 | 108 | 37 | 71 | 66% | 0-0 | 2.00 | 0.78 |
| 2012-07-06 | Tommy Milone | L | 25 | L 4-1 | vs SEA | 17 | 22 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 9 | 103 | 37 | 66 | 64% | 8-6 | 3.58 | 1.19 |
| 2012-07-07 | Jarrod Parker | R | 24 | W 1-7 | vs SEA | 14 | 15 | L | 4.2 | 6 | 6 | 6 | 1 | 2 | 6 | 92 | 41 | 51 | 55% | 5-4 | 2.96 | 1.25 |
| 2012-07-08 | Bartolo Colon | R | 37 | L 2-1 | vs SEA | 17 | 368 | - | 8.2 | 7 | 1 | 1 | 0 | 0 | 5 | 92 | 14 | 78 | 85% | 6-7 | 3.81 | 1.25 |
| 2012-07-13 | A.J. Griffin | R | 24 | W 6-3 | @ MIN | 4 | 4 | W | 6.0 | 8 | 3 | 3 | 2 | 1 | 5 | 97 | 28 | 69 | 71% | 1-0 | 2.63 | 0.96 |
| 2012-07-14 | Tommy Milone | L | 25 | W 9-3 | @ MIN | 18 | 23 | W | 6.0 | 10 | 2 | 2 | 1 | 1 | 4 | 94 | 31 | 63 | 67% | 9-6 | 3.55 | 1.22 |
| 2012-07-15 | Jarrod Parker | R | 24 | W 9-4 | @ MIN | 15 | 16 | W | 6.0 | 9 | 4 | 4 | 0 | 0 | 4 | 91 | 29 | 62 | 68% | 6-4 | 3.16 | 1.26 |
| 2012-07-17 | Bartolo Colon | R | 37 | W 1-6 | vs TEX | 18 | 369 | L | 7.0 | 8 | 4 | 4 | 1 | 1 | 5 | 97 | 30 | 67 | 69% | 6-8 | 3.89 | 1.25 |
| 2012-07-18 | Travis Blackley | L | 30 | L 4-3 | vs TEX | 8 | 16 | - | 5.1 | 6 | 3 | 3 | 0 | 1 | 4 | 89 | 29 | 60 | 67% | 2-2 | 3.34 | 1.06 |
| 2012-07-19 | A.J. Griffin | R | 24 | L 4-3 | vs NYA | 5 | 5 | W | 6.0 | 7 | 2 | 2 | 0 | 0 | 4 | 89 | 30 | 59 | 66% | 2-0 | 2.70 | 1.00 |
| 2012-07-20 | Tommy Milone | L | 25 | L 3-2 | vs NYA | 19 | 24 | - | 7.0 | 6 | 0 | 0 | 0 | 0 | 10 | 110 | 32 | 78 | 71% | 9-6 | 3.35 | 1.20 |
| 2012-07-21 | Jarrod Parker | R | 24 | L 2-1 | vs NYA | 16 | 17 | W | 8.0 | 5 | 1 | 1 | 0 | 1 | 5 | 100 | 34 | 66 | 66% | 7-4 | 3.00 | 1.22 |
| 2012-07-22 | Bartolo Colon | R | 37 | L 5-4 | vs NYA | 19 | 370 | - | 6.2 | 8 | 4 | 4 | 1 | 1 | 5 | 83 | 26 | 57 | 69% | 6-8 | 3.97 | 1.25 |
| 2012-07-24 | Travis Blackley | L | 30 | W 7-2 | @ TOR | 9 | 17 | W | 7.0 | 5 | 1 | 1 | 1 | 1 | 8 | 100 | 35 | 65 | 65% | 3-2 | 3.13 | 1.04 |
| 2012-07-25 | A.J. Griffin | R | 24 | W 16-0 | @ TOR | 6 | 6 | W | 6.0 | 3 | 0 | 0 | 0 | 2 | 9 | 103 | 37 | 66 | 64% | 3-0 | 2.25 | 0.97 |
| 2012-07-26 | Tommy Milone | L | 25 | L 4-10 | @ TOR | 20 | 25 | L | 7.0 | 8 | 6 | 5 | 2 | 0 | 7 | 89 | 27 | 62 | 70% | 9-7 | 3.52 | 1.20 |
| 2012-07-27 | Jarrod Parker | R | 24 | W 14-9 | @ BAL | 17 | 18 | - | 5.0 | 8 | 6 | 6 | 2 | 1 | 8 | 85 | 34 | 51 | 60% | 7-4 | 3.38 | 1.25 |
| 2012-07-28 | Bartolo Colon | R | 37 | W 6-1 | @ BAL | 20 | 371 | W | 5.2 | 7 | 0 | 0 | 0 | 1 | 5 | 100 | 32 | 68 | 68% | 7-8 | 3.77 | 1.26 |
| 2012-07-29 | Travis Blackley | L | 30 | L 1-6 | @ BAL | 10 | 18 | L | 5.0 | 6 | 5 | 5 | 1 | 4 | 1 | 96 | 36 | 60 | 63% | 3-3 | 3.53 | 1.11 |
| 2012-07-30 | A.J. Griffin | R | 25 | L 4-3 | vs TBA | 7 | 7 | - | 7.0 | 5 | 3 | 3 | 1 | 2 | 6 | 104 | 41 | 63 | 61% | 3-0 | 2.51 | 0.98 |
| 2012-07-31 | Tommy Milone | L | 25 | W 0-8 | vs TBA | 21 | 26 | L | 6.0 | 7 | 5 | 5 | 0 | 1 | 4 | 94 | 38 | 56 | 60% | 9-8 | 3.69 | 1.20 |
| 2012-08-01 | Jarrod Parker | R | 24 | W 1-4 | vs TBA | 18 | 19 | L | 6.0 | 8 | 3 | 3 | 0 | 3 | 2 | 104 | 44 | 60 | 58% | 7-5 | 3.44 | 1.28 |
| 2012-08-02 | Bartolo Colon | R | 37 | L 4-1 | vs TOR | 21 | 372 | W | 8.0 | 7 | 0 | 0 | 0 | 1 | 3 | 96 | 28 | 68 | 71% | 8-8 | 3.55 | 1.24 |
| 2012-08-03 | Dan Straily | R | 24 | L 5-4 | vs TOR | 1 | 1 | - | 6.0 | 5 | 1 | 1 | 0 | 1 | 5 | 102 | 32 | 70 | 69% | 0-0 | 1.50 | 1.00 |
| 2012-08-04 | A.J. Griffin | R | 25 | W 1-3 | vs TOR | 8 | 8 | - | 1.2 | 1 | 0 | 0 | 0 | 0 | 0 | 30 | 12 | 18 | 60% | 3-0 | 2.40 | 0.96 |
| 2012-08-05 | Tommy Milone | L | 25 | W 5-6 | vs TOR | 22 | 27 | L | 6.0 | 9 | 6 | 6 | 1 | 1 | 4 | 105 | 35 | 70 | 67% | 9-9 | 3.92 | 1.22 |
| 2012-08-06 | Jarrod Parker | R | 24 | W 0-4 | vs ANA | 19 | 20 | L | 6.2 | 9 | 4 | 4 | 0 | 1 | 6 | 96 | 40 | 56 | 58% | 7-6 | 3.54 | 1.29 |
| 2012-08-07 | Bartolo Colon | R | 37 | L 10-4 | vs ANA | 22 | 373 | W | 7.0 | 4 | 1 | 0 | 0 | 0 | 5 | 93 | 21 | 72 | 77% | 9-8 | 3.37 | 1.21 |
| 2012-08-08 | Dan Straily | R | 24 | L 9-8 | vs ANA | 2 | 2 | - | 4.2 | 8 | 5 | 5 | 4 | 1 | 5 | 102 | 39 | 63 | 62% | 0-0 | 4.91 | 1.36 |
| 2012-08-10 | Brandon McCarthy | R | 29 | L 3-4 | @ CHA | 13 | 94 | - | 6.0 | 6 | 3 | 3 | 3 | 1 | 4 | 87 | 26 | 61 | 70% | 6-3 | 2.68 | 1.20 |
| 2012-08-11 | Travis Blackley | L | 30 | W 9-7 | @ CHA | 11 | 19 | - | 5.0 | 6 | 5 | 5 | 1 | 1 | 6 | 84 | 34 | 50 | 60% | 4-3 | 3.96 | 1.14 |
| 2012-08-12 | Bartolo Colon | R | 37 | L 3-7 | @ CHA | 23 | 374 | L | 5.2 | 9 | 6 | 5 | 1 | 2 | 2 | 93 | 34 | 59 | 63% | 9-9 | 3.56 | 1.24 |
| 2012-08-14 | Jarrod Parker | R | 24 | L 0-5 | @ KCA | 20 | 21 | L | 4.2 | 5 | 5 | 4 | 0 | 2 | 3 | 80 | 29 | 51 | 64% | 7-7 | 3.72 | 1.31 |
| 2012-08-15 | Brandon McCarthy | R | 29 | L 2-3 | @ KCA | 14 | 95 | L | 6.2 | 7 | 3 | 2 | 0 | 0 | 4 | 100 | 35 | 65 | 65% | 6-4 | 2.67 | 1.19 |
| 2012-08-16 | Dan Straily | R | 24 | W 3-0 | @ KCA | 3 | 3 | W | 6.1 | 3 | 0 | 0 | 0 | 2 | 2 | 99 | 32 | 67 | 68% | 1-0 | 3.18 | 1.18 |
| 2012-08-17 | Tommy Milone | L | 26 | L 6-4 | vs CLE | 23 | 28 | - | 5.0 | 7 | 4 | 4 | 1 | 1 | 6 | 94 | 35 | 59 | 63% | 9-9 | 4.03 | 1.23 |
| 2012-08-18 | Bartolo Colon | R | 37 | L 8-5 | vs CLE | 24 | 375 | W | 8.0 | 5 | 1 | 1 | 1 | 0 | 3 | 103 | 29 | 74 | 72% | 10-9 | 3.43 | 1.21 |
| 2012-08-19 | Jarrod Parker | R | 24 | L 7-0 | vs CLE | 21 | 22 | W | 8.0 | 6 | 0 | 0 | 0 | 1 | 2 | 92 | 29 | 63 | 68% | 8-7 | 3.49 | 1.28 |
| 2012-08-20 | Brandon McCarthy | R | 29 | W 2-7 | vs MIN | 15 | 96 | L | 3.1 | 10 | 6 | 6 | 0 | 1 | 2 | 86 | 34 | 52 | 60% | 6-5 | 3.16 | 1.27 |
| 2012-08-21 | Brett Anderson | L | 25 | L 4-1 | vs MIN | 1 | 63 | W | 7.0 | 4 | 1 | 1 | 0 | 0 | 6 | 82 | 24 | 58 | 71% | 1-0 | 1.29 | 0.57 |
| 2012-08-22 | Tommy Milone | L | 26 | L 5-1 | vs MIN | 24 | 29 | W | 8.0 | 2 | 1 | 1 | 0 | 1 | 5 | 100 | 33 | 67 | 67% | 10-9 | 3.88 | 1.19 |
| 2012-08-23 | Tyson Ross | R | 25 | L 0-5 | @ TBA | 13 | 21 | L | 6.0 | 9 | 5 | 5 | 0 | 2 | 6 | 95 | 41 | 54 | 57% | 2-9 | 6.49 | 1.76 |
| 2012-08-24 | Jarrod Parker | R | 24 | W 5-4 | @ TBA | 22 | 23 | - | 6.0 | 7 | 3 | 3 | 1 | 2 | 7 | 102 | 44 | 58 | 57% | 8-7 | 3.53 | 1.29 |
| 2012-08-25 | Brandon McCarthy | R | 29 | W 4-2 | @ TBA | 16 | 97 | W | 7.0 | 4 | 2 | 2 | 1 | 2 | 7 | 104 | 39 | 65 | 63% | 7-5 | 3.12 | 1.24 |
| 2012-08-27 | Brett Anderson | L | 25 | W 3-0 | @ CLE | 2 | 64 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 5 | 94 | 35 | 59 | 63% | 2-0 | 0.64 | 0.57 |
| 2012-08-28 | Tommy Milone | L | 26 | W 7-0 | @ CLE | 25 | 30 | W | 6.0 | 7 | 0 | 0 | 0 | 1 | 5 | 102 | 32 | 70 | 69% | 11-9 | 3.74 | 1.19 |
| 2012-08-29 | Travis Blackley | L | 30 | W 8-4 | @ CLE | 12 | 20 | W | 5.2 | 3 | 2 | 2 | 1 | 2 | 5 | 91 | 36 | 55 | 60% | 5-3 | 3.79 | 1.13 |
| 2012-08-30 | Jarrod Parker | R | 24 | W 12-7 | @ CLE | 23 | 24 | W | 5.0 | 8 | 5 | 5 | 1 | 3 | 3 | 110 | 49 | 61 | 55% | 9-7 | 3.73 | 1.32 |
| 2012-08-31 | Brandon McCarthy | R | 29 | L 20-2 | vs BOS | 17 | 98 | W | 6.1 | 8 | 2 | 2 | 1 | 0 | 1 | 102 | 31 | 71 | 70% | 8-5 | 3.11 | 1.24 |
| 2012-09-01 | A.J. Griffin | R | 25 | L 7-1 | vs BOS | 9 | 9 | W | 7.0 | 3 | 1 | 1 | 0 | 0 | 5 | 90 | 28 | 62 | 69% | 4-0 | 2.25 | 0.88 |
| 2012-09-02 | Brett Anderson | L | 25 | L 6-2 | vs BOS | 3 | 65 | W | 6.0 | 5 | 1 | 1 | 0 | 1 | 4 | 90 | 30 | 60 | 67% | 3-0 | 0.90 | 0.70 |
| 2012-09-03 | Tommy Milone | L | 26 | W 3-8 | vs ANA | 26 | 31 | L | 3.0 | 10 | 5 | 5 | 2 | 0 | 1 | 67 | 22 | 45 | 67% | 11-10 | 3.94 | 1.23 |
| 2012-09-04 | Jarrod Parker | R | 24 | W 1-6 | vs ANA | 24 | 25 | L | 7.0 | 8 | 2 | 2 | 0 | 0 | 5 | 102 | 35 | 67 | 66% | 9-8 | 3.67 | 1.31 |
| 2012-09-05 | Brandon McCarthy | R | 29 | W 1-7 | vs ANA | 18 | 99 | L | 3.2 | 5 | 3 | 3 | 0 | 1 | 3 | 54 | 19 | 35 | 65% | 8-6 | 3.24 | 1.25 |
| 2012-09-07 | A.J. Griffin | R | 25 | W 6-1 | @ SEA | 10 | 10 | W | 5.1 | 6 | 1 | 1 | 0 | 1 | 7 | 108 | 44 | 64 | 59% | 5-0 | 2.21 | 0.93 |
| 2012-09-08 | Brett Anderson | L | 25 | W 6-1 | @ SEA | 4 | 66 | W | 6.0 | 6 | 1 | 0 | 0 | 0 | 4 | 107 | 37 | 70 | 65% | 4-0 | 0.69 | 0.77 |
| 2012-09-09 | Tommy Milone | L | 26 | W 4-2 | @ SEA | 27 | 32 | W | 6.0 | 8 | 2 | 2 | 1 | 0 | 10 | 105 | 38 | 67 | 64% | 12-10 | 3.91 | 1.24 |
| 2012-09-10 | Jarrod Parker | R | 24 | W 3-1 | @ ANA | 25 | 26 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 2 | 101 | 42 | 59 | 58% | 10-8 | 3.56 | 1.29 |
| 2012-09-11 | Dan Straily | R | 24 | W 6-5 | @ ANA | 4 | 4 | W | 6.2 | 7 | 3 | 3 | 2 | 1 | 8 | 108 | 36 | 72 | 67% | 2-0 | 3.38 | 1.17 |
| 2012-09-12 | A.J. Griffin | R | 25 | W 4-1 | @ ANA | 11 | 11 | W | 8.0 | 6 | 0 | 0 | 0 | 0 | 6 | 106 | 35 | 71 | 67% | 6-0 | 1.94 | 0.91 |
| 2012-09-13 | Brett Anderson | L | 25 | L 0-6 | @ ANA | 5 | 67 | L | 6.2 | 9 | 5 | 5 | 1 | 1 | 5 | 100 | 37 | 63 | 63% | 4-1 | 1.91 | 0.91 |
| 2012-09-14 | Tommy Milone | L | 26 | L 3-2 | vs BAL | 28 | 33 | W | 6.1 | 6 | 2 | 1 | 1 | 2 | 2 | 91 | 35 | 56 | 62% | 13-10 | 3.81 | 1.23 |
| 2012-09-15 | Jarrod Parker | R | 24 | L 5-2 | vs BAL | 26 | 27 | W | 7.0 | 7 | 2 | 2 | 1 | 1 | 5 | 93 | 31 | 62 | 67% | 11-8 | 3.52 | 1.29 |
| 2012-09-16 | Dan Straily | R | 24 | W 5-9 | vs BAL | 5 | 5 | L | 4.2 | 5 | 4 | 4 | 2 | 5 | 1 | 92 | 41 | 51 | 55% | 2-1 | 4.18 | 1.36 |
| 2012-09-18 | A.J. Griffin | R | 25 | L 2-12 | @ DET | 12 | 12 | L | 4.2 | 8 | 5 | 5 | 3 | 1 | 3 | 97 | 34 | 63 | 65% | 6-1 | 2.44 | 0.97 |
| 2012-09-19 | Brett Anderson | L | 25 | L 2-6 | @ DET | 6 | 68 | L | 2.1 | 3 | 3 | 3 | 0 | 3 | 1 | 42 | 19 | 23 | 55% | 4-2 | 2.57 | 1.03 |
| 2012-09-20 | Tommy Milone | L | 26 | W 12-4 | @ DET | 29 | 34 | - | 4.2 | 9 | 3 | 3 | 0 | 3 | 1 | 95 | 41 | 54 | 57% | 13-10 | 3.87 | 1.27 |
| 2012-09-21 | Jarrod Parker | R | 24 | L 1-2 | @ NYA | 27 | 28 | - | 8.0 | 6 | 1 | 1 | 0 | 0 | 7 | 108 | 34 | 74 | 69% | 11-8 | 3.41 | 1.26 |
| 2012-09-22 | Travis Blackley | L | 30 | L 9-10 | @ NYA | 13 | 21 | - | 2.0 | 5 | 4 | 3 | 1 | 3 | 1 | 63 | 32 | 31 | 49% | 5-3 | 3.83 | 1.19 |
| 2012-09-23 | A.J. Griffin | R | 25 | W 5-4 | @ NYA | 13 | 13 | - | 4.1 | 7 | 4 | 4 | 1 | 3 | 4 | 108 | 39 | 69 | 64% | 6-1 | 2.80 | 1.05 |
| 2012-09-24 | Dan Straily | R | 24 | L 4-5 | @ TEX | 6 | 6 | - | 6.2 | 5 | 2 | 1 | 1 | 2 | 8 | 99 | 41 | 58 | 59% | 2-1 | 3.60 | 1.29 |
| 2012-09-25 | Tommy Milone | L | 26 | W 3-2 | @ TEX | 30 | 35 | - | 6.0 | 6 | 2 | 0 | 0 | 0 | 3 | 114 | 38 | 76 | 67% | 13-10 | 3.75 | 1.26 |
| 2012-09-26 | Jarrod Parker | R | 24 | W 9-3 | @ TEX | 28 | 29 | W | 6.0 | 5 | 3 | 3 | 0 | 3 | 8 | 108 | 39 | 69 | 64% | 12-8 | 3.45 | 1.26 |
| 2012-09-27 | Travis Blackley | L | 30 | L 7-9 | @ TEX | 14 | 22 | L | 1.0 | 5 | 5 | 5 | 2 | 0 | 0 | 27 | 14 | 13 | 48% | 5-4 | 4.24 | 1.23 |
| 2012-09-28 | A.J. Griffin | R | 25 | L 8-2 | vs SEA | 14 | 14 | W | 5.2 | 4 | 1 | 1 | 1 | 2 | 4 | 96 | 36 | 60 | 63% | 7-1 | 2.70 | 1.05 |
| 2012-09-29 | Dan Straily | R | 24 | L 7-4 | vs SEA | 7 | 7 | - | 4.1 | 3 | 4 | 3 | 2 | 4 | 3 | 72 | 35 | 37 | 51% | 2-1 | 3.92 | 1.33 |
| 2012-09-30 | Tommy Milone | L | 26 | L 5-2 | vs SEA | 31 | 36 | - | 4.2 | 9 | 2 | 2 | 0 | 0 | 3 | 85 | 34 | 51 | 60% | 13-10 | 3.74 | 1.28 |
| 2012-10-01 | Jarrod Parker | R | 24 | L 4-3 | vs TEX | 29 | 30 | W | 6.0 | 6 | 3 | 3 | 2 | 2 | 6 | 94 | 32 | 62 | 66% | 13-8 | 3.48 | 1.27 |
| 2012-10-02 | Travis Blackley | L | 30 | L 3-1 | vs TEX | 15 | 23 | W | 6.0 | 3 | 1 | 1 | 0 | 2 | 5 | 83 | 32 | 51 | 61% | 6-4 | 4.08 | 1.20 |
| 2012-10-03 | A.J. Griffin | R | 25 | L 12-5 | vs TEX | 15 | 15 | - | 2.2 | 7 | 5 | 4 | 0 | 2 | 0 | 70 | 26 | 44 | 63% | 7-1 | 3.07 | 1.13 |