| 2012-03-28 | vs SEA | 1 | L 1-3 | 0-1 | 2 | 44,227 | Brandon McCarthy | Felix Hernandez | Tom Wilhelmsen | Andrew Carignan | Brandon League | 1 | 3 | -2 |
| 2012-03-29 | vs SEA | 2 | W 4-1 | 1-1 | 1 | 43,391 | Bartolo Colon | Jason Vargas | Bartolo Colon | Shawn Kelley | Grant Balfour | 5 | 4 | 1 |
| 2012-04-06 | vs SEA | 3 | L 3-7 | 1-2 | 4 | 35,067 | Brandon McCarthy | Jason Vargas | Jason Vargas | Brandon McCarthy | | 8 | 11 | -3 |
| 2012-04-07 | vs SEA | 4 | L 7-8 | 1-3 | 4 | 16,612 | Bartolo Colon | Felix Hernandez | Felix Hernandez | Bartolo Colon | Brandon League | 15 | 19 | -4 |
| 2012-04-09 | vs KCA | 5 | W 1-0 | 2-3 | 4 | 10,054 | Tom Milone | Luis Mendoza | Tom Milone | Luis Mendoza | Grant Balfour | 16 | 19 | -3 |
| 2012-04-10 | vs KCA | 6 | L 0-3 | 2-4 | 4 | 10,670 | Graham Godfrey | Danny Duffy | Danny Duffy | Graham Godfrey | Aaron Crow | 16 | 22 | -6 |
| 2012-04-11 | vs KCA | 7 | W 5-4 | 3-4 | 3 | 12,390 | Brandon McCarthy | Bruce Chen | Andrew Carignan | Jonathan Broxton | | 21 | 26 | -5 |
| 2012-04-13 | @ SEA | 8 | W 4-0 | 4-4 | 3 | 46,026 | Bartolo Colon | Felix Hernandez | Bartolo Colon | Felix Hernandez | | 25 | 26 | -1 |
| 2012-04-14 | @ SEA | 9 | L 0-4 | 4-5 | 4 | 21,071 | Tom Milone | Hector Noesi | Hector Noesi | Tom Milone | | 25 | 30 | -5 |
| 2012-04-15 | @ SEA | 10 | L 3-5 | 4-6 | 4 | 19,650 | Graham Godfrey | Blake Beavan | Blake Beavan | Graham Godfrey | Brandon League | 28 | 35 | -7 |
| 2012-04-16 | @ ANA | 11 | L 0-6 | 4-7 | 4 | 27,338 | Brandon McCarthy | Jered Weaver | Jered Weaver | Brandon McCarthy | | 28 | 41 | -13 |
| 2012-04-17 | @ ANA | 12 | W 5-3 | 5-7 | 4 | 41,016 | Tyson Ross | Dan Haren | Brian Fuentes | Kevin Jepsen | Grant Balfour | 33 | 44 | -11 |
| 2012-04-18 | @ ANA | 13 | W 6-0 | 6-7 | 4 | 27,217 | Bartolo Colon | Ervin Santana | Bartolo Colon | Ervin Santana | | 39 | 44 | -5 |
| 2012-04-19 | @ ANA | 14 | W 4-2 | 7-7 | 3 | 27,864 | Tom Milone | C.J. Wilson | Tom Milone | C.J. Wilson | Grant Balfour | 43 | 46 | -3 |
| 2012-04-20 | vs CLE | 15 | L 3-4 | 7-8 | 4 | 14,340 | Graham Godfrey | Ubaldo Jimenez | Ubaldo Jimenez | Graham Godfrey | Chris Perez | 46 | 50 | -4 |
| 2012-04-21 | vs CLE | 16 | L 1-5 | 7-9 | 5 | 25,258 | Brandon McCarthy | Jeanmar Gomez | Jeanmar Gomez | Brandon McCarthy | Chris Perez | 47 | 55 | -8 |
| 2012-04-22 | vs CLE | 17 | W 5-1 | 8-9 | 3 | 24,049 | Tyson Ross | Justin Masterson | Tyson Ross | Justin Masterson | | 52 | 56 | -4 |
| 2012-04-23 | vs CHA | 18 | L 0-4 | 8-10 | 4 | 10,574 | Bartolo Colon | Jake Peavy | Jake Peavy | Bartolo Colon | | 52 | 60 | -8 |
| 2012-04-24 | vs CHA | 19 | W 2-0 | 9-10 | 3 | 11,184 | Tom Milone | Gavin Floyd | Tom Milone | Gavin Floyd | Grant Balfour | 54 | 60 | -6 |
| 2012-04-25 | vs CHA | 20 | W 5-4 | 10-10 | 3 | 13,032 | Jarrod Parker | Chris Sale | Jim Miller | Hector Santiago | | 59 | 64 | -5 |
| 2012-04-27 | @ BAL | 21 | W 5-2 | 11-10 | 3 | 18,297 | Brandon McCarthy | Jake Arrieta | Brandon McCarthy | Jake Arrieta | Grant Balfour | 64 | 66 | -2 |
| 2012-04-28 | @ BAL | 22 | L 1-10 | 11-11 | 3 | 26,926 | Tyson Ross | Wei-Yin Chen | Wei-Yin Chen | Tyson Ross | | 65 | 76 | -11 |
| 2012-04-29 | @ BAL | 23 | L 2-5 | 11-12 | 3 | 31,793 | Bartolo Colon | Tommy Hunter | Pedro Strop | Grant Balfour | | 67 | 81 | -14 |
| 2012-04-30 | @ BOS | 24 | W 6-11 | 12-12 | 2 | 37,359 | Tom Milone | Clay Buchholz | Clay Buchholz | Tom Milone | | 73 | 92 | -19 |
| 2012-05-01 | @ BOS | 25 | W 5-3 | 13-12 | 2 | 37,225 | Jarrod Parker | Felix Doubront | Jarrod Parker | Felix Doubront | Jordan Norberto | 78 | 95 | -17 |
| 2012-05-02 | @ BOS | 26 | W 4-2 | 14-12 | 2 | 37,434 | Brandon McCarthy | Daniel Bard | Brandon McCarthy | Daniel Bard | Brian Fuentes | 82 | 97 | -15 |
| 2012-05-04 | @ TBA | 27 | L 2-7 | 14-13 | 2 | 18,799 | Tyson Ross | David Price | David Price | Tyson Ross | Joel Peralta | 84 | 104 | -20 |
| 2012-05-05 | @ TBA | 28 | W 4-3 | 15-13 | 2 | 23,890 | Bartolo Colon | Jeremy Hellickson | Brian Fuentes | Joel Peralta | Grant Balfour | 88 | 107 | -19 |
| 2012-05-06 | @ TBA | 29 | W 9-5 | 16-13 | 1 | 23,873 | Tom Milone | Matt Moore | Tom Milone | Matt Moore | | 97 | 112 | -15 |
| 2012-05-08 | vs TOR | 30 | W 7-3 | 17-13 | 1 | 10,784 | Jarrod Parker | Ricky Romero | Grant Balfour | Francisco Cordero | | 104 | 115 | -11 |
| 2012-05-09 | vs TOR | 31 | L 2-5 | 17-14 | 1 | 14,815 | Tyson Ross | Brandon Morrow | Brandon Morrow | Tyson Ross | Casey Janssen | 106 | 120 | -14 |
| 2012-05-10 | vs DET | 32 | W 6-10 | 18-14 | 1 | 11,513 | Bartolo Colon | Max Scherzer | Max Scherzer | Bartolo Colon | | 112 | 130 | -18 |
| 2012-05-11 | vs DET | 33 | L 11-4 | 18-15 | 1 | 26,721 | Tom Milone | Rick Porcello | Tom Milone | Rick Porcello | | 123 | 134 | -11 |
| 2012-05-12 | vs DET | 34 | W 3-1 | 19-15 | 1 | 20,077 | Brandon McCarthy | Doug Fister | Brandon McCarthy | Doug Fister | Brian Fuentes | 126 | 135 | -9 |
| 2012-05-13 | vs DET | 35 | L 1-3 | 19-16 | 2 | 17,147 | Jarrod Parker | Justin Verlander | Justin Verlander | Jarrod Parker | Jose Valverde | 127 | 138 | -11 |
| 2012-05-14 | @ ANA | 36 | W 5-0 | 20-16 | 1 | 32,851 | Tyson Ross | Dan Haren | Tyson Ross | Dan Haren | | 132 | 138 | -6 |
| 2012-05-15 | @ ANA | 37 | L 0-4 | 20-17 | 2 | 31,762 | Bartolo Colon | Ervin Santana | Ervin Santana | Bartolo Colon | | 132 | 142 | -10 |
| 2012-05-16 | @ TEX | 38 | L 1-4 | 20-18 | 2 | 46,370 | Tom Milone | Yu Darvish | Yu Darvish | Tom Milone | Joe Nathan | 133 | 146 | -13 |
| 2012-05-17 | @ TEX | 39 | W 5-4 | 21-18 | 2 | 47,182 | Brandon McCarthy | Matt Harrison | Ryan Cook | Mike Adams | Brian Fuentes | 138 | 150 | -12 |
| 2012-05-18 | @ SFN | 40 | L 6-8 | 21-19 | 2 | 41,477 | Jarrod Parker | Barry Zito | Barry Zito | Jarrod Parker | Santiago Casilla | 144 | 158 | -14 |
| 2012-05-19 | @ SFN | 41 | L 0-4 | 21-20 | 2 | 41,411 | Tyson Ross | Ryan Vogelsong | Ryan Vogelsong | Tyson Ross | | 144 | 162 | -18 |
| 2012-05-20 | @ SFN | 42 | W 6-2 | 22-20 | 2 | 41,378 | Bartolo Colon | Tim Lincecum | Bartolo Colon | Tim Lincecum | | 150 | 164 | -14 |
| 2012-05-21 | vs ANA | 43 | W 2-1 | 23-20 | 1 | 11,292 | Tom Milone | Jerome Williams | Tom Milone | Jerome Williams | Brian Fuentes | 152 | 165 | -13 |
| 2012-05-22 | vs ANA | 44 | L 0-5 | 23-21 | 2 | 12,894 | Graham Godfrey | C.J. Wilson | C.J. Wilson | Graham Godfrey | | 152 | 170 | -18 |
| 2012-05-23 | vs ANA | 45 | L 1-3 | 23-22 | 2 | 23,617 | Jarrod Parker | Jered Weaver | Jordan Walden | Jordan Norberto | Ernesto Frieri | 153 | 173 | -20 |
| 2012-05-25 | vs NYA | 46 | L 3-6 | 23-23 | 2 | 33,559 | Tyson Ross | Ivan Nova | Ivan Nova | Tyson Ross | Rafael Soriano | 156 | 179 | -23 |
| 2012-05-26 | vs NYA | 47 | L 2-9 | 23-24 | 2 | 27,112 | Bartolo Colon | CC Sabathia | CC Sabathia | Bartolo Colon | | 158 | 188 | -30 |
| 2012-05-27 | vs NYA | 48 | L 0-2 | 23-25 | 2 | 25,078 | Tom Milone | Hiroki Kuroda | Hiroki Kuroda | Tom Milone | Rafael Soriano | 158 | 190 | -32 |
| 2012-05-28 | @ MIN | 49 | L 4-5 | 23-26 | 2 | 34,709 | Travis Blackley | Scott Diamond | Alex Burnett | Ryan Cook | Matt Capps | 162 | 195 | -33 |
| 2012-05-29 | @ MIN | 50 | L 2-3 | 23-27 | 2 | 31,781 | Jarrod Parker | Cole De Vries | Glen Perkins | Brian Fuentes | | 164 | 198 | -34 |
| 2012-05-30 | @ MIN | 51 | L 0-4 | 23-28 | 3 | 35,103 | Tyson Ross | Francisco Liriano | Francisco Liriano | Tyson Ross | | 164 | 202 | -38 |
| 2012-06-01 | @ KCA | 52 | L 0-2 | 23-29 | 3 | 29,527 | Bartolo Colon | Felipe Paulino | Felipe Paulino | Bartolo Colon | Jonathan Broxton | 164 | 204 | -40 |
| 2012-06-02 | @ KCA | 53 | W 9-3 | 24-29 | 2 | 26,276 | Brandon McCarthy | Luke Hochevar | Brandon McCarthy | Luke Hochevar | | 173 | 207 | -34 |
| 2012-06-03 | @ KCA | 54 | L 0-2 | 24-30 | 3 | 21,111 | Tom Milone | Vin Mazzaro | Vin Mazzaro | Tom Milone | Jonathan Broxton | 173 | 209 | -36 |
| 2012-06-04 | vs TEX | 55 | W 12-1 | 25-30 | 2 | 10,120 | Jarrod Parker | Scott Feldman | Jarrod Parker | Scott Feldman | | 185 | 210 | -25 |
| 2012-06-05 | vs TEX | 56 | L 3-6 | 25-31 | 3 | 11,861 | Travis Blackley | Derek Holland | Derek Holland | Travis Blackley | Joe Nathan | 188 | 216 | -28 |
| 2012-06-06 | vs TEX | 57 | W 2-0 | 26-31 | 2 | 15,044 | Bartolo Colon | Colby Lewis | Bartolo Colon | Colby Lewis | Brian Fuentes | 190 | 216 | -26 |
| 2012-06-07 | vs TEX | 58 | W 7-1 | 27-31 | 2 | 14,779 | Brandon McCarthy | Yu Darvish | Brandon McCarthy | Yu Darvish | | 197 | 217 | -20 |
| 2012-06-08 | @ ARI | 59 | L 8-9 | 27-32 | 2 | 25,787 | Tom Milone | Daniel Hudson | J.J. Putz | Brian Fuentes | | 205 | 226 | -21 |
| 2012-06-09 | @ ARI | 60 | L 3-8 | 27-33 | 2 | 28,061 | Jarrod Parker | Trevor Cahill | Trevor Cahill | Jarrod Parker | | 208 | 234 | -26 |
| 2012-06-10 | @ ARI | 61 | L 3-4 | 27-34 | 3 | 28,112 | Travis Blackley | Joe Saunders | Joe Saunders | Travis Blackley | J.J. Putz | 211 | 238 | -27 |
| 2012-06-12 | @ COL | 62 | W 8-5 | 28-34 | 3 | 33,635 | Bartolo Colon | Jeremy Guthrie | Bartolo Colon | Jeremy Guthrie | Ryan Cook | 219 | 243 | -24 |
| 2012-06-13 | @ COL | 63 | L 10-8 | 28-35 | 3 | 32,155 | Tom Milone | Josh Outman | Jerry Blevins | Rafael Betancourt | Ryan Cook | 229 | 251 | -22 |
| 2012-06-14 | @ COL | 64 | W 8-2 | 29-35 | 3 | 32,527 | Jarrod Parker | Alex White | Jarrod Parker | Alex White | | 237 | 253 | -16 |
| 2012-06-15 | vs SDN | 65 | L 10-2 | 29-36 | 3 | 24,528 | Travis Blackley | Anthony Bass | Travis Blackley | Anthony Bass | Evan Scribner | 247 | 255 | -8 |
| 2012-06-16 | vs SDN | 66 | W 6-4 | 30-36 | 3 | 17,135 | Tyson Ross | Ross Ohlendorf | Sean Doolittle | Joe Thatcher | Ryan Cook | 253 | 259 | -6 |
| 2012-06-17 | vs SDN | 67 | L 1-2 | 30-37 | 3 | 21,631 | Bartolo Colon | Clayton Richard | Clayton Richard | Bartolo Colon | Huston Street | 254 | 261 | -7 |
| 2012-06-19 | vs LAN | 68 | W 3-0 | 31-37 | 3 | 20,244 | Brandon McCarthy | Aaron Harang | Brandon McCarthy | Aaron Harang | Ryan Cook | 257 | 261 | -4 |
| 2012-06-20 | vs LAN | 69 | W 4-1 | 32-37 | 3 | 25,383 | Tom Milone | Nathan Eovaldi | Tom Milone | Nathan Eovaldi | | 261 | 262 | -1 |
| 2012-06-21 | vs LAN | 70 | W 4-1 | 33-37 | 3 | 23,337 | Travis Blackley | Clayton Kershaw | Ryan Cook | Josh Lindblom | | 265 | 263 | 2 |
| 2012-06-22 | vs SFN | 71 | L 4-5 | 33-38 | 3 | 35,067 | Jarrod Parker | Tim Lincecum | Clay Hensley | Ryan Cook | Santiago Casilla | 269 | 268 | 1 |
| 2012-06-23 | vs SFN | 72 | L 8-9 | 33-39 | 3 | 36,067 | Tyson Ross | Madison Bumgarner | Madison Bumgarner | Tyson Ross | Clay Hensley | 277 | 277 | 0 |
| 2012-06-24 | vs SFN | 73 | W 4-2 | 34-39 | 3 | 36,067 | A.J. Griffin | Matt Cain | Jim Miller | Santiago Casilla | | 281 | 279 | 2 |
| 2012-06-25 | @ SEA | 74 | W 1-0 | 35-39 | 3 | 17,101 | Tom Milone | Erasmo Ramirez | Tom Milone | Erasmo Ramirez | Ryan Cook | 282 | 279 | 3 |
| 2012-06-26 | @ SEA | 75 | L 2-3 | 35-40 | 3 | 12,411 | Travis Blackley | Jason Vargas | Charlie Furbush | Jim Miller | Tom Wilhelmsen | 284 | 282 | 2 |
| 2012-06-27 | @ SEA | 76 | W 2-1 | 36-40 | 3 | 18,158 | Jarrod Parker | Kevin Millwood | Jarrod Parker | Hisashi Iwakuma | Ryan Cook | 286 | 283 | 3 |
| 2012-06-28 | @ TEX | 77 | L 6-7 | 36-41 | 3 | 33,927 | Tyson Ross | Scott Feldman | Scott Feldman | Tyson Ross | Joe Nathan | 292 | 290 | 2 |
| 2012-06-29 | @ TEX | 78 | L 3-4 | 36-42 | 3 | 46,013 | A.J. Griffin | Matt Harrison | Matt Harrison | Grant Balfour | Tanner Scheppers | 295 | 294 | 1 |
| 2012-06-30 | @ TEX | 79 | L 2-7 | 36-43 | 3 | 46,711 | Tom Milone | Martin Perez | Martin Perez | Tom Milone | | 297 | 301 | -4 |
| 2012-07-01 | @ TEX | 80 | W 3-1 | 37-43 | 3 | 45,741 | Travis Blackley | Yu Darvish | Travis Blackley | Yu Darvish | Ryan Cook | 300 | 302 | -2 |
| 2012-07-02 | vs BOS | 81 | W 6-1 | 38-43 | 3 | 17,434 | Jarrod Parker | Daisuke Matsuzaka | Jarrod Parker | Daisuke Matsuzaka | | 306 | 303 | 3 |
| 2012-07-03 | vs BOS | 82 | W 3-2 | 39-43 | 3 | 35,067 | Bartolo Colon | Jon Lester | Jerry Blevins | Alfredo Aceves | | 309 | 305 | 4 |
| 2012-07-04 | vs BOS | 83 | W 3-2 | 40-43 | 3 | 28,240 | A.J. Griffin | Aaron Cook | Grant Balfour | Aaron Cook | Ryan Cook | 312 | 307 | 5 |
| 2012-07-06 | vs SEA | 84 | W 4-1 | 41-43 | 3 | 10,819 | Tom Milone | Kevin Millwood | Jordan Norberto | Oliver Perez | | 316 | 308 | 8 |
| 2012-07-07 | vs SEA | 85 | L 1-7 | 41-44 | 3 | 16,136 | Jarrod Parker | Jason Vargas | Jason Vargas | Jarrod Parker | | 317 | 315 | 2 |
| 2012-07-08 | vs SEA | 86 | W 2-1 | 42-44 | 3 | 20,075 | Bartolo Colon | Felix Hernandez | Jordan Norberto | Oliver Perez | | 319 | 316 | 3 |
| 2012-07-13 | @ MIN | 87 | W 6-3 | 43-44 | 3 | 33,230 | A.J. Griffin | Francisco Liriano | A.J. Griffin | Francisco Liriano | Ryan Cook | 325 | 319 | 6 |
| 2012-07-14 | @ MIN | 88 | W 9-3 | 44-44 | 3 | 39,084 | Tom Milone | Cole De Vries | Tom Milone | Cole De Vries | | 334 | 322 | 12 |
| 2012-07-15 | @ MIN | 89 | W 9-4 | 45-44 | 3 | 36,853 | Jarrod Parker | Brian Duensing | Jarrod Parker | Brian Duensing | | 343 | 326 | 17 |
| 2012-07-17 | vs TEX | 90 | L 1-6 | 45-45 | 3 | 15,115 | Bartolo Colon | Roy Oswalt | Roy Oswalt | Bartolo Colon | | 344 | 332 | 12 |
| 2012-07-18 | vs TEX | 91 | W 4-3 | 46-45 | 3 | 20,249 | Travis Blackley | Colby Lewis | Ryan Cook | Michael Kirkman | | 348 | 335 | 13 |
| 2012-07-19 | vs NYA | 92 | W 4-3 | 47-45 | 3 | 23,382 | A.J. Griffin | Freddy Garcia | A.J. Griffin | Freddy Garcia | Ryan Cook | 352 | 338 | 14 |
| 2012-07-20 | vs NYA | 93 | W 3-2 | 48-45 | 3 | 24,148 | Tom Milone | Ivan Nova | Ryan Cook | Cody Eppley | | 355 | 340 | 15 |
| 2012-07-21 | vs NYA | 94 | W 2-1 | 49-45 | 3 | 28,142 | Jarrod Parker | Phil Hughes | Jarrod Parker | Phil Hughes | Sean Doolittle | 357 | 341 | 16 |
| 2012-07-22 | vs NYA | 95 | W 5-4 | 50-45 | 3 | 30,470 | Bartolo Colon | CC Sabathia | Jerry Blevins | Cody Eppley | | 362 | 345 | 17 |
| 2012-07-24 | @ TOR | 96 | W 7-2 | 51-45 | 3 | 25,686 | Travis Blackley | Brett Cecil | Travis Blackley | Brett Cecil | | 369 | 347 | 22 |
| 2012-07-25 | @ TOR | 97 | W 16-0 | 52-45 | 3 | 23,948 | A.J. Griffin | Ricky Romero | A.J. Griffin | Ricky Romero | | 385 | 347 | 38 |
| 2012-07-26 | @ TOR | 98 | W 4-10 | 53-45 | 3 | 39,003 | Tom Milone | Aaron Laffey | Brandon Lyon | Tom Milone | | 389 | 357 | 32 |
| 2012-07-27 | @ BAL | 99 | L 14-9 | 53-46 | 3 | 29,278 | Jarrod Parker | Zachary Britton | Jerry Blevins | Jim Johnson | | 403 | 366 | 37 |
| 2012-07-28 | @ BAL | 100 | W 6-1 | 54-46 | 2 | 21,143 | Bartolo Colon | Tommy Hunter | Bartolo Colon | Tommy Hunter | | 409 | 367 | 42 |
| 2012-07-29 | @ BAL | 101 | L 1-6 | 54-47 | 3 | 19,698 | Travis Blackley | Wei-Yin Chen | Wei-Yin Chen | Travis Blackley | | 410 | 373 | 37 |
| 2012-07-30 | vs TBA | 102 | W 4-3 | 55-47 | 2 | 12,564 | A.J. Griffin | David Price | Jordan Norberto | Kyle Farnsworth | | 414 | 376 | 38 |
| 2012-07-31 | vs TBA | 103 | L 0-8 | 55-48 | 3 | 15,836 | Tom Milone | James Shields | James Shields | Tom Milone | | 414 | 384 | 30 |
| 2012-08-01 | vs TBA | 104 | L 1-4 | 55-49 | 3 | 18,161 | Jarrod Parker | Alex Cobb | Alex Cobb | Jarrod Parker | Fernando Rodney | 415 | 388 | 27 |
| 2012-08-02 | vs TOR | 105 | W 4-1 | 56-49 | 3 | 10,823 | Bartolo Colon | Henderson Alvarez | Bartolo Colon | Henderson Alvarez | Ryan Cook | 419 | 389 | 30 |
| 2012-08-03 | vs TOR | 106 | W 5-4 | 57-49 | 2 | 30,169 | Dan Straily | Brett Cecil | Travis Blackley | Aaron Loup | | 424 | 393 | 31 |
| 2012-08-04 | vs TOR | 107 | L 1-3 | 57-50 | 3 | 17,121 | A.J. Griffin | Ricky Romero | Jesse Chavez | Jerry Blevins | Darren Oliver | 425 | 396 | 29 |
| 2012-08-05 | vs TOR | 108 | L 5-6 | 57-51 | 3 | 18,308 | Tom Milone | Aaron Laffey | Aaron Laffey | Tom Milone | Casey Janssen | 430 | 402 | 28 |
| 2012-08-06 | vs ANA | 109 | L 0-4 | 57-52 | 3 | 13,341 | Jarrod Parker | Jered Weaver | Jered Weaver | Jarrod Parker | | 430 | 406 | 24 |
| 2012-08-07 | vs ANA | 110 | L 10-4 | 57-53 | 3 | 15,458 | Bartolo Colon | C.J. Wilson | Bartolo Colon | C.J. Wilson | | 440 | 410 | 30 |
| 2012-08-08 | vs ANA | 111 | W 9-8 | 58-53 | 3 | 21,150 | Dan Straily | Zack Greinke | Pat Neshek | LaTroy Hawkins | Ryan Cook | 449 | 418 | 31 |
| 2012-08-10 | @ CHA | 112 | L 3-4 | 58-54 | 3 | 25,041 | Brandon McCarthy | Gavin Floyd | Brett Myers | Pat Neshek | | 452 | 422 | 30 |
| 2012-08-11 | @ CHA | 113 | W 9-7 | 59-54 | 3 | 26,686 | Travis Blackley | Francisco Liriano | Ryan Cook | Matt Thornton | Grant Balfour | 461 | 429 | 32 |
| 2012-08-12 | @ CHA | 114 | L 3-7 | 59-55 | 3 | 25,106 | Bartolo Colon | Chris Sale | Chris Sale | Bartolo Colon | | 464 | 436 | 28 |
| 2012-08-14 | @ KCA | 115 | L 0-5 | 59-56 | 3 | 16,107 | Jarrod Parker | Jeremy Guthrie | Jeremy Guthrie | Jarrod Parker | | 464 | 441 | 23 |
| 2012-08-15 | @ KCA | 116 | L 2-3 | 59-57 | 3 | 15,591 | Brandon McCarthy | Will Smith | Will Smith | Brandon McCarthy | Greg Holland | 466 | 444 | 22 |
| 2012-08-16 | @ KCA | 117 | W 3-0 | 60-57 | 3 | 14,345 | Dan Straily | Luke Hochevar | Dan Straily | Luke Hochevar | Grant Balfour | 469 | 444 | 25 |
| 2012-08-17 | vs CLE | 118 | W 6-4 | 61-57 | 2 | 13,967 | Tom Milone | Zach McAllister | Jordan Norberto | Joe Smith | Grant Balfour | 475 | 448 | 27 |
| 2012-08-18 | vs CLE | 119 | W 8-5 | 62-57 | 2 | 30,132 | Bartolo Colon | Corey Kluber | Bartolo Colon | Corey Kluber | Grant Balfour | 483 | 453 | 30 |
| 2012-08-19 | vs CLE | 120 | W 7-0 | 63-57 | 2 | 20,130 | Jarrod Parker | Justin Masterson | Jarrod Parker | Justin Masterson | | 490 | 453 | 37 |
| 2012-08-20 | vs MIN | 121 | L 2-7 | 63-58 | 2 | 10,274 | Brandon McCarthy | Brian Duensing | Brian Duensing | Brandon McCarthy | | 492 | 460 | 32 |
| 2012-08-21 | vs MIN | 122 | W 4-1 | 64-58 | 2 | 13,116 | Brett Anderson | Cole De Vries | Brett Anderson | Cole De Vries | Grant Balfour | 496 | 461 | 35 |
| 2012-08-22 | vs MIN | 123 | W 5-1 | 65-58 | 2 | 16,657 | Tom Milone | Liam Hendriks | Tom Milone | Liam Hendriks | | 501 | 462 | 39 |
| 2012-08-23 | @ TBA | 124 | L 0-5 | 65-59 | 2 | 11,613 | Tyson Ross | Alex Cobb | Alex Cobb | Tyson Ross | | 501 | 467 | 34 |
| 2012-08-24 | @ TBA | 125 | W 5-4 | 66-59 | 2 | 18,913 | Jarrod Parker | Matt Moore | Ryan Cook | Joel Peralta | Grant Balfour | 506 | 471 | 35 |
| 2012-08-25 | @ TBA | 126 | W 4-2 | 67-59 | 2 | 18,187 | Brandon McCarthy | Jeremy Hellickson | Brandon McCarthy | Jeremy Hellickson | Grant Balfour | 510 | 473 | 37 |
| 2012-08-27 | @ CLE | 127 | W 3-0 | 68-59 | 2 | 13,018 | Brett Anderson | Fausto Carmona | Brett Anderson | Fausto Carmona | Grant Balfour | 513 | 473 | 40 |
| 2012-08-28 | @ CLE | 128 | W 7-0 | 69-59 | 2 | 13,413 | Tom Milone | Zach McAllister | Tom Milone | Zach McAllister | | 520 | 473 | 47 |
| 2012-08-29 | @ CLE | 129 | W 8-4 | 70-59 | 1 | 14,412 | Travis Blackley | Corey Kluber | Travis Blackley | Corey Kluber | Ryan Cook | 528 | 477 | 51 |
| 2012-08-30 | @ CLE | 130 | L 12-7 | 70-60 | 2 | 14,500 | Jarrod Parker | Justin Masterson | Jarrod Parker | Justin Masterson | | 540 | 484 | 56 |
| 2012-08-31 | vs BOS | 131 | W 20-2 | 71-60 | 2 | 20,121 | Brandon McCarthy | Aaron Cook | Brandon McCarthy | Aaron Cook | | 560 | 486 | 74 |
| 2012-09-01 | vs BOS | 132 | W 7-1 | 72-60 | 2 | 20,315 | A.J. Griffin | Felix Doubront | A.J. Griffin | Felix Doubront | | 567 | 487 | 80 |
| 2012-09-02 | vs BOS | 133 | W 6-2 | 73-60 | 1 | 25,314 | Brett Anderson | Daisuke Matsuzaka | Brett Anderson | Daisuke Matsuzaka | | 573 | 489 | 84 |
| 2012-09-03 | vs ANA | 134 | L 3-8 | 73-61 | 2 | 20,180 | Tom Milone | C.J. Wilson | C.J. Wilson | Tom Milone | | 576 | 497 | 79 |
| 2012-09-04 | vs ANA | 135 | L 1-6 | 73-62 | 2 | 11,688 | Jarrod Parker | Zack Greinke | Zack Greinke | Jarrod Parker | | 577 | 503 | 74 |
| 2012-09-05 | vs ANA | 136 | L 1-7 | 73-63 | 2 | 15,404 | Brandon McCarthy | Dan Haren | Dan Haren | Brandon McCarthy | | 578 | 510 | 68 |
| 2012-09-07 | @ SEA | 137 | W 6-1 | 74-63 | 2 | 17,128 | A.J. Griffin | Felix Hernandez | A.J. Griffin | Felix Hernandez | | 584 | 511 | 73 |
| 2012-09-08 | @ SEA | 138 | W 6-1 | 75-63 | 2 | 23,177 | Brett Anderson | Hisashi Iwakuma | Brett Anderson | Hisashi Iwakuma | | 590 | 512 | 78 |
| 2012-09-09 | @ SEA | 139 | W 4-2 | 76-63 | 2 | 14,403 | Tom Milone | Jason Vargas | Tom Milone | Jason Vargas | Grant Balfour | 594 | 514 | 80 |
| 2012-09-10 | @ ANA | 140 | W 3-1 | 77-63 | 2 | 36,064 | Jarrod Parker | Dan Haren | Jarrod Parker | Dan Haren | Grant Balfour | 597 | 515 | 82 |
| 2012-09-11 | @ ANA | 141 | W 6-5 | 78-63 | 2 | 37,794 | Dan Straily | Jerome Williams | Dan Straily | Jerome Williams | Jerry Blevins | 603 | 520 | 83 |
| 2012-09-12 | @ ANA | 142 | W 4-1 | 79-63 | 1 | 38,097 | A.J. Griffin | Ervin Santana | A.J. Griffin | Ervin Santana | Ryan Cook | 607 | 521 | 86 |
| 2012-09-13 | @ ANA | 143 | L 0-6 | 79-64 | 2 | 38,029 | Brett Anderson | Jered Weaver | Jered Weaver | Brett Anderson | | 607 | 527 | 80 |
| 2012-09-14 | vs BAL | 144 | W 3-2 | 80-64 | 2 | 35,067 | Tom Milone | Joe Saunders | Tom Milone | Joe Saunders | Grant Balfour | 610 | 529 | 81 |
| 2012-09-15 | vs BAL | 145 | W 5-2 | 81-64 | 1 | 20,342 | Jarrod Parker | Zachary Britton | Jarrod Parker | Zachary Britton | Grant Balfour | 615 | 531 | 84 |
| 2012-09-16 | vs BAL | 146 | L 5-9 | 81-65 | 2 | 20,539 | Dan Straily | Randy Wolf | Brian Matusz | Dan Straily | Jim Johnson | 620 | 540 | 80 |
| 2012-09-18 | @ DET | 147 | W 2-12 | 82-65 | 1 | 31,243 | A.J. Griffin | Max Scherzer | Darin Downs | A.J. Griffin | | 622 | 552 | 70 |
| 2012-09-19 | @ DET | 148 | L 2-6 | 82-66 | 1 | 29,734 | Brett Anderson | Justin Verlander | Justin Verlander | Brett Anderson | | 624 | 558 | 66 |
| 2012-09-20 | @ DET | 149 | L 12-4 | 82-67 | 1 | 34,635 | Tom Milone | Anibal Sanchez | Pat Neshek | Anibal Sanchez | | 636 | 562 | 74 |
| 2012-09-21 | @ NYA | 150 | L 1-2 | 82-68 | 2 | 40,759 | Jarrod Parker | CC Sabathia | David Robertson | Sean Doolittle | | 637 | 564 | 73 |
| 2012-09-22 | @ NYA | 151 | W 9-10 | 83-68 | 2 | 44,026 | Travis Blackley | Ivan Nova | Cory Wade | Tyson Ross | | 646 | 574 | 72 |
| 2012-09-23 | @ NYA | 152 | W 5-4 | 84-68 | 2 | 43,867 | A.J. Griffin | Hiroki Kuroda | Jerry Blevins | Hiroki Kuroda | Grant Balfour | 651 | 578 | 73 |
| 2012-09-24 | @ TEX | 153 | L 4-5 | 84-69 | 2 | 43,044 | Dan Straily | Derek Holland | Joe Nathan | Tyson Ross | | 655 | 583 | 72 |
| 2012-09-25 | @ TEX | 154 | W 3-2 | 85-69 | 2 | 43,874 | Tom Milone | Scott Feldman | Evan Scribner | Mark Lowe | Grant Balfour | 658 | 585 | 73 |
| 2012-09-26 | @ TEX | 155 | W 9-3 | 86-69 | 2 | 46,689 | Jarrod Parker | Martin Perez | Jarrod Parker | Martin Perez | | 667 | 588 | 79 |
| 2012-09-27 | @ TEX | 156 | L 7-9 | 86-70 | 2 | 43,796 | Travis Blackley | Matt Harrison | Matt Harrison | Travis Blackley | Joe Nathan | 674 | 597 | 77 |
| 2012-09-28 | vs SEA | 157 | W 8-2 | 87-70 | 2 | 16,376 | A.J. Griffin | Blake Beavan | A.J. Griffin | Blake Beavan | | 682 | 599 | 83 |
| 2012-09-29 | vs SEA | 158 | W 7-4 | 88-70 | 2 | 21,517 | Dan Straily | Jason Vargas | Grant Balfour | Oliver Perez | | 689 | 603 | 86 |
| 2012-09-30 | vs SEA | 159 | W 5-2 | 89-70 | 3 | 21,057 | Tom Milone | Erasmo Ramirez | Sean Doolittle | Shawn Kelley | Grant Balfour | 694 | 605 | 89 |
| 2012-10-01 | vs TEX | 160 | W 4-3 | 90-70 | 2 | 21,162 | Jarrod Parker | Martin Perez | Jarrod Parker | Martin Perez | Grant Balfour | 698 | 608 | 90 |
| 2012-10-02 | vs TEX | 161 | W 3-1 | 91-70 | 1 | 30,660 | Travis Blackley | Matt Harrison | Travis Blackley | Matt Harrison | Grant Balfour | 701 | 609 | 92 |
| 2012-10-03 | vs TEX | 162 | L 12-5 | 91-71 | 1 | 36,067 | A.J. Griffin | Ryan Dempster | Evan Scribner | Derek Holland | | 713 | 614 | 99 |