| Central | W | L | Pct | GB |
| Cincinnati | 97 | 65 | .599 | -- |
| St. Louis | 88 | 74 | .543 | 9.0 |
| Milwaukee | 83 | 79 | .512 | 14.0 |
| Pittsburgh | 79 | 83 | .488 | 18.0 |
| Chi Cubs | 61 | 101 | .377 | 36.0 |
| Houston | 55 | 107 | .340 | 42.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-06 | Yovani Gallardo | R | 26 | W 5-11 | vs SLN | 1 | 116 | L | 3.2 | 7 | 6 | 6 | 4 | 5 | 3 | 89 | 44 | 45 | 51% | 0-1 | 13.50 | 3.00 |
| 2012-04-07 | Zack Greinke | R | 28 | L 6-0 | vs SLN | 1 | 198 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 7 | 91 | 30 | 61 | 67% | 1-0 | 0.00 | 0.57 |
| 2012-04-08 | Randy Wolf | L | 36 | W 3-9 | vs SLN | 1 | 343 | L | 5.0 | 9 | 3 | 3 | 0 | 1 | 7 | 106 | 40 | 66 | 62% | 0-1 | 5.40 | 2.00 |
| 2012-04-09 | Shaun Marcum | R | 30 | W 7-5 | @ CHN | 1 | 129 | W | 6.0 | 5 | 3 | 3 | 2 | 0 | 6 | 89 | 27 | 62 | 70% | 1-0 | 4.50 | 0.83 |
| 2012-04-10 | Chris Narveson | L | 30 | W 7-4 | @ CHN | 1 | 62 | W | 5.0 | 6 | 3 | 2 | 0 | 2 | 4 | 88 | 37 | 51 | 58% | 1-0 | 3.60 | 1.60 |
| 2012-04-11 | Yovani Gallardo | R | 26 | W 2-1 | @ CHN | 2 | 117 | W | 7.0 | 5 | 1 | 1 | 0 | 2 | 6 | 106 | 39 | 67 | 63% | 1-1 | 5.73 | 1.73 |
| 2012-04-12 | Zack Greinke | R | 28 | L 0-8 | @ CHN | 2 | 199 | L | 3.2 | 9 | 8 | 8 | 0 | 1 | 5 | 86 | 31 | 55 | 64% | 1-1 | 6.55 | 1.27 |
| 2012-04-13 | Randy Wolf | L | 36 | L 8-10 | @ ATL | 2 | 344 | - | 4.1 | 9 | 8 | 8 | 2 | 3 | 1 | 98 | 42 | 56 | 57% | 0-1 | 11.00 | 2.44 |
| 2012-04-14 | Shaun Marcum | R | 30 | L 1-2 | @ ATL | 2 | 130 | L | 7.0 | 3 | 2 | 2 | 0 | 2 | 6 | 108 | 41 | 67 | 62% | 1-1 | 3.46 | 0.77 |
| 2012-04-15 | Chris Narveson | L | 30 | L 4-7 | @ ATL | 2 | 63 | L | 4.0 | 4 | 5 | 5 | 2 | 2 | 1 | 73 | 34 | 39 | 53% | 1-1 | 7.00 | 1.56 |
| 2012-04-17 | Yovani Gallardo | R | 26 | L 5-4 | vs LAN | 3 | 118 | - | 7.0 | 7 | 2 | 2 | 0 | 1 | 7 | 97 | 38 | 59 | 61% | 1-1 | 4.50 | 1.50 |
| 2012-04-18 | Zack Greinke | R | 28 | L 3-2 | vs LAN | 3 | 200 | - | 7.0 | 4 | 2 | 2 | 0 | 2 | 7 | 104 | 43 | 61 | 59% | 1-1 | 5.00 | 1.11 |
| 2012-04-19 | Randy Wolf | L | 36 | W 3-4 | vs LAN | 3 | 345 | L | 6.0 | 7 | 4 | 4 | 1 | 1 | 1 | 99 | 42 | 57 | 58% | 0-2 | 9.00 | 2.00 |
| 2012-04-20 | Shaun Marcum | R | 30 | W 3-4 | vs COL | 3 | 131 | - | 6.0 | 8 | 3 | 3 | 1 | 2 | 5 | 105 | 42 | 63 | 60% | 1-1 | 3.79 | 1.05 |
| 2012-04-21 | Marco Estrada | R | 29 | L 9-4 | vs COL | 1 | 10 | - | 5.0 | 2 | 1 | 1 | 1 | 0 | 9 | 75 | 27 | 48 | 64% | 0-0 | 2.45 | 0.91 |
| 2012-04-22 | Yovani Gallardo | R | 26 | W 1-4 | vs COL | 4 | 119 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 8 | 106 | 40 | 66 | 62% | 1-1 | 3.60 | 1.36 |
| 2012-04-23 | Zack Greinke | R | 29 | L 6-5 | vs HOU | 4 | 201 | W | 6.0 | 8 | 2 | 2 | 1 | 2 | 9 | 114 | 44 | 70 | 61% | 2-1 | 4.50 | 1.25 |
| 2012-04-24 | Randy Wolf | L | 36 | L 9-6 | vs HOU | 4 | 346 | W | 6.0 | 4 | 2 | 2 | 1 | 4 | 4 | 109 | 47 | 62 | 57% | 1-2 | 7.29 | 1.81 |
| 2012-04-25 | Shaun Marcum | R | 30 | W 5-7 | vs HOU | 4 | 132 | - | 5.0 | 8 | 4 | 3 | 0 | 4 | 7 | 98 | 39 | 59 | 60% | 1-1 | 4.13 | 1.33 |
| 2012-04-27 | Yovani Gallardo | R | 26 | L 1-13 | @ SLN | 5 | 120 | L | 2.0 | 8 | 8 | 8 | 0 | 2 | 3 | 67 | 29 | 38 | 57% | 1-2 | 6.00 | 1.63 |
| 2012-04-28 | Marco Estrada | R | 29 | L 3-7 | @ SLN | 2 | 11 | L | 6.0 | 7 | 5 | 4 | 2 | 2 | 2 | 78 | 23 | 55 | 71% | 0-1 | 3.71 | 1.12 |
| 2012-04-29 | Zack Greinke | R | 29 | W 3-2 | @ SLN | 5 | 202 | W | 6.0 | 7 | 1 | 1 | 0 | 4 | 2 | 99 | 43 | 56 | 57% | 3-1 | 3.90 | 1.37 |
| 2012-04-30 | Randy Wolf | L | 36 | W 8-3 | @ SDN | 5 | 347 | W | 5.0 | 9 | 3 | 3 | 0 | 3 | 3 | 92 | 38 | 54 | 59% | 2-2 | 6.92 | 1.92 |
| 2012-05-01 | Shaun Marcum | R | 30 | L 0-2 | @ SDN | 5 | 133 | - | 7.0 | 3 | 0 | 0 | 0 | 4 | 6 | 110 | 43 | 67 | 61% | 1-1 | 3.19 | 1.26 |
| 2012-05-02 | Yovani Gallardo | R | 26 | L 0-5 | @ SDN | 6 | 121 | L | 6.0 | 7 | 3 | 3 | 0 | 3 | 4 | 108 | 47 | 61 | 56% | 1-3 | 5.73 | 1.64 |
| 2012-05-04 | Zack Greinke | R | 29 | W 6-4 | @ SFN | 6 | 203 | - | 5.1 | 7 | 4 | 3 | 0 | 1 | 5 | 98 | 37 | 61 | 62% | 3-1 | 4.11 | 1.40 |
| 2012-05-05 | Randy Wolf | L | 36 | L 2-5 | @ SFN | 6 | 348 | L | 6.0 | 9 | 4 | 4 | 0 | 0 | 3 | 104 | 34 | 70 | 67% | 2-3 | 6.75 | 1.84 |
| 2012-05-06 | Shaun Marcum | R | 30 | L 3-4 | @ SFN | 6 | 134 | - | 6.0 | 5 | 3 | 3 | 0 | 2 | 3 | 83 | 30 | 53 | 64% | 1-1 | 3.41 | 1.24 |
| 2012-05-07 | Marco Estrada | R | 29 | W 1-6 | vs CIN | 3 | 12 | L | 7.0 | 8 | 5 | 5 | 2 | 0 | 5 | 110 | 33 | 77 | 70% | 0-2 | 4.50 | 1.13 |
| 2012-05-08 | Yovani Gallardo | R | 26 | L 8-3 | vs CIN | 7 | 122 | W | 6.0 | 4 | 2 | 2 | 1 | 2 | 8 | 101 | 43 | 58 | 57% | 2-3 | 5.31 | 1.54 |
| 2012-05-09 | Zack Greinke | R | 29 | W 1-2 | vs CIN | 7 | 204 | - | 8.0 | 2 | 0 | 0 | 0 | 0 | 11 | 101 | 35 | 66 | 65% | 3-1 | 3.35 | 1.19 |
| 2012-05-11 | Randy Wolf | L | 36 | L 8-7 | vs CHN | 7 | 349 | - | 6.0 | 4 | 0 | 0 | 0 | 3 | 5 | 96 | 34 | 62 | 65% | 2-3 | 5.68 | 1.74 |
| 2012-05-12 | Shaun Marcum | R | 30 | L 8-2 | vs CHN | 7 | 135 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 6 | 103 | 38 | 65 | 63% | 2-1 | 3.07 | 1.16 |
| 2012-05-13 | Marco Estrada | R | 29 | W 2-8 | vs CHN | 4 | 13 | - | 6.0 | 5 | 2 | 2 | 2 | 1 | 4 | 82 | 27 | 55 | 67% | 0-2 | 4.20 | 1.10 |
| 2012-05-14 | Yovani Gallardo | R | 26 | L 1-3 | @ NYN | 8 | 123 | L | 6.0 | 2 | 2 | 2 | 0 | 6 | 6 | 107 | 48 | 59 | 55% | 2-4 | 5.00 | 1.51 |
| 2012-05-15 | Zack Greinke | R | 29 | W 8-0 | @ NYN | 8 | 205 | W | 7.0 | 5 | 0 | 0 | 0 | 0 | 7 | 102 | 36 | 66 | 65% | 4-1 | 2.88 | 1.12 |
| 2012-05-16 | Randy Wolf | L | 36 | L 3-8 | @ HOU | 8 | 350 | L | 4.0 | 7 | 7 | 6 | 0 | 3 | 1 | 84 | 35 | 49 | 58% | 2-4 | 6.43 | 1.81 |
| 2012-05-17 | Shaun Marcum | R | 30 | L 0-4 | @ HOU | 8 | 136 | L | 5.0 | 9 | 4 | 3 | 1 | 1 | 5 | 95 | 33 | 62 | 65% | 2-2 | 3.31 | 1.24 |
| 2012-05-18 | Marco Estrada | R | 29 | W 3-11 | vs MIN | 5 | 14 | L | 5.0 | 6 | 4 | 4 | 1 | 1 | 5 | 101 | 36 | 65 | 64% | 0-3 | 4.63 | 1.14 |
| 2012-05-19 | Yovani Gallardo | R | 26 | W 4-5 | vs MIN | 9 | 124 | - | 6.0 | 3 | 2 | 1 | 0 | 3 | 3 | 107 | 41 | 66 | 62% | 2-4 | 4.59 | 1.45 |
| 2012-05-20 | Zack Greinke | R | 29 | L 16-4 | vs MIN | 9 | 206 | W | 6.2 | 5 | 1 | 1 | 0 | 2 | 6 | 111 | 43 | 68 | 61% | 5-1 | 2.68 | 1.11 |
| 2012-05-21 | Randy Wolf | L | 36 | W 3-4 | vs SFN | 9 | 351 | - | 7.0 | 5 | 3 | 3 | 1 | 3 | 4 | 113 | 46 | 67 | 59% | 2-4 | 6.06 | 1.71 |
| 2012-05-22 | Shaun Marcum | R | 30 | W 4-6 | vs SFN | 9 | 137 | L | 6.0 | 5 | 6 | 6 | 2 | 2 | 5 | 108 | 41 | 67 | 62% | 2-3 | 3.93 | 1.24 |
| 2012-05-23 | Marco Estrada | R | 29 | L 8-5 | vs SFN | 6 | 15 | - | 1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 10 | 1 | 9 | 90% | 0-3 | 4.50 | 1.11 |
| 2012-05-25 | Yovani Gallardo | R | 26 | W 7-1 | @ ARI | 10 | 125 | W | 7.1 | 5 | 1 | 1 | 1 | 3 | 5 | 108 | 42 | 66 | 61% | 3-4 | 4.19 | 1.41 |
| 2012-05-26 | Zack Greinke | R | 29 | L 5-8 | @ ARI | 10 | 207 | L | 2.1 | 10 | 7 | 7 | 1 | 3 | 3 | 70 | 28 | 42 | 60% | 5-2 | 3.66 | 1.29 |
| 2012-05-27 | Randy Wolf | L | 36 | L 3-4 | @ ARI | 10 | 352 | - | 5.2 | 7 | 3 | 2 | 1 | 1 | 1 | 114 | 42 | 72 | 63% | 2-4 | 5.73 | 1.67 |
| 2012-05-28 | Shaun Marcum | R | 30 | W 3-2 | @ LAN | 10 | 138 | W | 7.0 | 6 | 1 | 1 | 0 | 2 | 9 | 120 | 40 | 80 | 67% | 3-3 | 3.63 | 1.23 |
| 2012-05-29 | Mike Fiers | R | 27 | W 2-1 | @ LAN | 1 | 1 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 3 | 89 | 25 | 64 | 72% | 1-0 | 1.29 | 0.71 |
| 2012-05-30 | Yovani Gallardo | R | 26 | W 6-3 | @ LAN | 11 | 126 | W | 6.0 | 8 | 3 | 3 | 0 | 3 | 8 | 111 | 48 | 63 | 57% | 4-4 | 4.22 | 1.45 |
| 2012-05-31 | Zack Greinke | R | 29 | W 6-2 | @ LAN | 11 | 208 | W | 6.0 | 9 | 1 | 1 | 0 | 1 | 7 | 122 | 42 | 80 | 66% | 6-2 | 3.46 | 1.32 |
| 2012-06-01 | Randy Wolf | L | 36 | W 2-8 | vs PIT | 11 | 353 | L | 6.0 | 8 | 6 | 6 | 0 | 4 | 5 | 115 | 42 | 73 | 63% | 2-5 | 6.05 | 1.70 |
| 2012-06-02 | Shaun Marcum | R | 30 | L 5-1 | vs PIT | 11 | 139 | W | 7.0 | 5 | 1 | 1 | 1 | 0 | 8 | 112 | 32 | 80 | 71% | 4-3 | 3.39 | 1.17 |
| 2012-06-03 | Mike Fiers | R | 27 | W 5-6 | vs PIT | 2 | 2 | L | 5.0 | 8 | 4 | 4 | 2 | 1 | 8 | 99 | 32 | 67 | 68% | 1-1 | 3.75 | 1.17 |
| 2012-06-05 | Yovani Gallardo | R | 26 | W 0-10 | vs CHN | 12 | 127 | L | 6.0 | 6 | 5 | 5 | 2 | 1 | 10 | 109 | 39 | 70 | 64% | 4-5 | 4.50 | 1.43 |
| 2012-06-06 | Zack Greinke | R | 29 | L 8-0 | vs CHN | 12 | 209 | W | 7.0 | 2 | 0 | 0 | 0 | 2 | 12 | 107 | 41 | 66 | 62% | 7-2 | 3.13 | 1.25 |
| 2012-06-07 | Randy Wolf | L | 36 | L 4-3 | vs CHN | 12 | 354 | - | 6.2 | 4 | 1 | 0 | 0 | 2 | 6 | 116 | 41 | 75 | 65% | 2-5 | 5.43 | 1.62 |
| 2012-06-08 | Shaun Marcum | R | 30 | L 9-5 | vs SDN | 12 | 140 | W | 5.2 | 6 | 3 | 3 | 2 | 3 | 6 | 112 | 41 | 71 | 63% | 5-3 | 3.48 | 1.20 |
| 2012-06-09 | Mike Fiers | R | 27 | W 2-5 | vs SDN | 3 | 3 | L | 6.0 | 10 | 4 | 4 | 0 | 1 | 6 | 91 | 29 | 62 | 68% | 1-2 | 4.50 | 1.39 |
| 2012-06-10 | Yovani Gallardo | R | 26 | L 6-5 | vs SDN | 13 | 128 | W | 7.0 | 5 | 2 | 1 | 1 | 2 | 5 | 100 | 40 | 60 | 60% | 5-5 | 4.21 | 1.39 |
| 2012-06-12 | Zack Greinke | R | 29 | L 1-2 | @ KCA | 13 | 210 | - | 7.0 | 6 | 1 | 1 | 1 | 0 | 8 | 105 | 36 | 69 | 66% | 7-2 | 2.96 | 1.22 |
| 2012-06-13 | Randy Wolf | L | 36 | L 3-4 | @ KCA | 13 | 355 | - | 7.0 | 6 | 1 | 1 | 0 | 2 | 1 | 95 | 40 | 55 | 58% | 2-5 | 5.04 | 1.57 |
| 2012-06-14 | Shaun Marcum | R | 30 | L 3-4 | @ KCA | 13 | 141 | - | 7.2 | 4 | 2 | 2 | 1 | 2 | 5 | 99 | 33 | 66 | 67% | 5-3 | 3.40 | 1.17 |
| 2012-06-15 | Yovani Gallardo | R | 26 | W 5-3 | @ MIN | 14 | 129 | - | 6.0 | 8 | 3 | 3 | 2 | 2 | 7 | 110 | 38 | 72 | 65% | 5-5 | 4.23 | 1.41 |
| 2012-06-16 | Mike Fiers | R | 27 | W 6-2 | @ MIN | 4 | 4 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 5 | 111 | 45 | 66 | 59% | 2-2 | 3.60 | 1.24 |
| 2012-06-17 | Zack Greinke | R | 29 | L 4-5 | @ MIN | 14 | 211 | - | 8.0 | 11 | 4 | 4 | 0 | 2 | 6 | 104 | 37 | 67 | 64% | 7-2 | 3.10 | 1.25 |
| 2012-06-18 | Randy Wolf | L | 36 | L 7-6 | vs TOR | 14 | 356 | - | 6.1 | 8 | 4 | 4 | 2 | 1 | 6 | 101 | 34 | 67 | 66% | 2-5 | 5.11 | 1.57 |
| 2012-06-19 | Tyler Thornburg | R | 24 | W 9-10 | vs TOR | 1 | 1 | - | 5.1 | 7 | 5 | 5 | 4 | 0 | 2 | 90 | 38 | 52 | 58% | 0-0 | 9.00 | 1.40 |
| 2012-06-20 | Yovani Gallardo | R | 26 | L 8-3 | vs TOR | 15 | 130 | W | 6.2 | 7 | 3 | 3 | 1 | 2 | 7 | 111 | 46 | 65 | 59% | 6-5 | 4.20 | 1.40 |
| 2012-06-22 | Zack Greinke | R | 29 | W 1-0 | @ CHA | 15 | 212 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 4 | 100 | 39 | 61 | 61% | 8-2 | 2.81 | 1.18 |
| 2012-06-23 | Randy Wolf | L | 36 | L 6-8 | @ CHA | 15 | 357 | - | 5.1 | 8 | 5 | 5 | 1 | 0 | 4 | 91 | 30 | 61 | 67% | 2-5 | 5.34 | 1.57 |
| 2012-06-24 | Mike Fiers | R | 27 | L 0-1 | @ CHA | 5 | 5 | - | 7.1 | 5 | 0 | 0 | 0 | 1 | 7 | 105 | 38 | 67 | 64% | 2-2 | 2.73 | 1.12 |
| 2012-06-25 | Yovani Gallardo | R | 26 | L 1-3 | @ CIN | 16 | 131 | L | 6.0 | 4 | 2 | 2 | 0 | 4 | 5 | 107 | 48 | 59 | 55% | 6-6 | 4.13 | 1.40 |
| 2012-06-26 | Marco Estrada | R | 29 | L 3-4 | @ CIN | 7 | 16 | - | 6.0 | 5 | 3 | 3 | 1 | 2 | 12 | 95 | 34 | 61 | 64% | 0-3 | 4.50 | 1.12 |
| 2012-06-27 | Zack Greinke | R | 29 | W 8-4 | @ CIN | 16 | 213 | W | 6.0 | 5 | 2 | 2 | 1 | 1 | 3 | 96 | 37 | 59 | 61% | 9-2 | 2.82 | 1.17 |
| 2012-06-29 | Randy Wolf | L | 36 | W 3-9 | vs ARI | 16 | 358 | L | 4.0 | 9 | 8 | 7 | 2 | 0 | 6 | 74 | 29 | 45 | 61% | 2-6 | 5.80 | 1.60 |
| 2012-06-30 | Mike Fiers | R | 27 | L 10-2 | vs ARI | 6 | 6 | W | 6.0 | 2 | 0 | 0 | 0 | 3 | 10 | 105 | 41 | 64 | 61% | 3-2 | 2.31 | 1.08 |
| 2012-07-01 | Yovani Gallardo | R | 26 | L 2-1 | vs ARI | 17 | 132 | - | 6.2 | 3 | 0 | 0 | 0 | 5 | 6 | 115 | 51 | 64 | 56% | 6-6 | 3.88 | 1.39 |
| 2012-07-02 | Zack Greinke | R | 29 | L 6-5 | vs MIA | 17 | 214 | - | 6.0 | 6 | 5 | 5 | 1 | 2 | 4 | 91 | 36 | 55 | 60% | 9-2 | 3.08 | 1.18 |
| 2012-07-03 | Marco Estrada | R | 29 | L 13-12 | vs MIA | 8 | 17 | - | 6.0 | 4 | 2 | 2 | 1 | 0 | 6 | 88 | 25 | 63 | 72% | 0-3 | 4.31 | 1.06 |
| 2012-07-04 | Randy Wolf | L | 36 | W 6-7 | vs MIA | 17 | 359 | - | 7.0 | 6 | 5 | 5 | 2 | 3 | 6 | 110 | 41 | 69 | 63% | 2-6 | 5.85 | 1.58 |
| 2012-07-05 | Mike Fiers | R | 27 | W 0-4 | vs MIA | 7 | 7 | L | 7.1 | 7 | 2 | 2 | 0 | 1 | 9 | 103 | 32 | 71 | 69% | 3-3 | 2.30 | 1.06 |
| 2012-07-06 | Yovani Gallardo | R | 26 | W 7-1 | @ HOU | 18 | 133 | W | 6.0 | 4 | 1 | 1 | 1 | 3 | 6 | 110 | 47 | 63 | 57% | 7-6 | 3.75 | 1.38 |
| 2012-07-07 | Zack Greinke | R | 29 | L 3-6 | @ HOU | 18 | 215 | L | 0.0 | 2 | 1 | 1 | 0 | 0 | 0 | 4 | 1 | 3 | 75% | 9-3 | 3.17 | 1.19 |
| 2012-07-08 | Zack Greinke | R | 29 | W 5-3 | @ HOU | 19 | 216 | - | 3.0 | 5 | 3 | 3 | 0 | 2 | 5 | 68 | 31 | 37 | 54% | 9-3 | 3.32 | 1.23 |
| 2012-07-13 | Zack Greinke | R | 29 | L 10-7 | vs PIT | 20 | 217 | - | 5.0 | 7 | 6 | 5 | 2 | 2 | 6 | 94 | 37 | 57 | 61% | 9-3 | 3.57 | 1.25 |
| 2012-07-14 | Marco Estrada | R | 29 | W 4-6 | vs PIT | 9 | 18 | - | 5.2 | 6 | 3 | 3 | 1 | 1 | 11 | 114 | 40 | 74 | 65% | 0-3 | 4.11 | 1.04 |
| 2012-07-15 | Yovani Gallardo | R | 26 | L 4-1 | vs PIT | 19 | 134 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 14 | 108 | 37 | 71 | 66% | 8-6 | 3.60 | 1.33 |
| 2012-07-16 | Mike Fiers | R | 27 | W 2-3 | vs SLN | 8 | 8 | - | 7.0 | 4 | 0 | 0 | 0 | 4 | 4 | 110 | 43 | 67 | 61% | 3-3 | 2.00 | 1.07 |
| 2012-07-17 | Randy Wolf | L | 36 | L 3-2 | vs SLN | 18 | 360 | W | 6.2 | 8 | 2 | 2 | 0 | 1 | 6 | 102 | 32 | 70 | 69% | 3-6 | 5.60 | 1.56 |
| 2012-07-18 | Tyler Thornburg | R | 24 | L 4-3 | vs SLN | 2 | 2 | - | 4.2 | 5 | 2 | 2 | 2 | 4 | 5 | 103 | 42 | 61 | 59% | 0-0 | 6.00 | 1.58 |
| 2012-07-20 | Marco Estrada | R | 29 | L 1-3 | @ CIN | 10 | 19 | L | 7.0 | 7 | 3 | 3 | 3 | 0 | 5 | 114 | 38 | 76 | 67% | 0-4 | 4.08 | 1.03 |
| 2012-07-21 | Yovani Gallardo | R | 26 | L 2-6 | @ CIN | 20 | 135 | L | 5.2 | 9 | 4 | 4 | 1 | 0 | 1 | 114 | 45 | 69 | 61% | 8-7 | 3.72 | 1.34 |
| 2012-07-22 | Mike Fiers | R | 27 | L 1-2 | @ CIN | 9 | 9 | L | 6.0 | 5 | 2 | 1 | 0 | 0 | 4 | 98 | 32 | 66 | 67% | 3-4 | 1.95 | 1.05 |
| 2012-07-23 | Randy Wolf | L | 36 | L 6-7 | @ PHI | 19 | 361 | - | 6.0 | 5 | 2 | 2 | 2 | 3 | 5 | 108 | 46 | 62 | 57% | 3-6 | 5.46 | 1.54 |
| 2012-07-24 | Zack Greinke | R | 29 | L 6-7 | @ PHI | 21 | 218 | - | 7.0 | 3 | 1 | 1 | 0 | 0 | 5 | 87 | 33 | 54 | 62% | 9-3 | 3.44 | 1.20 |
| 2012-07-25 | Marco Estrada | R | 29 | L 6-7 | @ PHI | 11 | 20 | - | 4.0 | 8 | 5 | 5 | 0 | 3 | 4 | 86 | 34 | 52 | 60% | 0-4 | 4.50 | 1.13 |
| 2012-07-26 | Yovani Gallardo | R | 26 | W 2-8 | vs WAS | 21 | 136 | L | 5.0 | 7 | 7 | 7 | 1 | 2 | 6 | 99 | 38 | 61 | 62% | 8-8 | 4.07 | 1.36 |
| 2012-07-27 | Mike Fiers | R | 27 | L 6-0 | vs WAS | 10 | 10 | W | 6.1 | 4 | 0 | 0 | 0 | 3 | 9 | 108 | 40 | 68 | 63% | 4-4 | 1.77 | 1.06 |
| 2012-07-28 | Randy Wolf | L | 36 | W 1-4 | vs WAS | 20 | 362 | L | 7.0 | 9 | 4 | 4 | 3 | 1 | 6 | 105 | 31 | 74 | 70% | 3-7 | 5.45 | 1.54 |
| 2012-07-29 | Mark Rogers | R | 26 | W 10-11 | vs WAS | 1 | 3 | - | 5.2 | 6 | 2 | 2 | 1 | 1 | 7 | 97 | 39 | 58 | 60% | 0-0 | 3.00 | 1.17 |
| 2012-07-30 | Marco Estrada | R | 29 | L 8-7 | vs HOU | 12 | 21 | - | 7.0 | 6 | 3 | 2 | 1 | 1 | 6 | 96 | 29 | 67 | 70% | 0-4 | 4.32 | 1.12 |
| 2012-07-31 | Yovani Gallardo | R | 26 | L 10-1 | vs HOU | 22 | 137 | W | 7.0 | 3 | 1 | 1 | 1 | 1 | 5 | 101 | 42 | 59 | 58% | 9-8 | 3.92 | 1.32 |
| 2012-08-01 | Mike Fiers | R | 27 | L 13-4 | vs HOU | 11 | 11 | W | 6.0 | 8 | 2 | 2 | 1 | 0 | 6 | 101 | 33 | 68 | 67% | 5-4 | 1.88 | 1.08 |
| 2012-08-03 | Randy Wolf | L | 36 | L 3-9 | @ SLN | 21 | 363 | L | 5.1 | 9 | 5 | 5 | 0 | 1 | 2 | 97 | 41 | 56 | 58% | 3-8 | 5.59 | 1.56 |
| 2012-08-04 | Mark Rogers | R | 27 | L 1-6 | @ SLN | 2 | 4 | L | 5.0 | 7 | 5 | 5 | 1 | 1 | 5 | 75 | 26 | 49 | 65% | 0-1 | 5.73 | 1.36 |
| 2012-08-05 | Marco Estrada | R | 29 | L 0-3 | @ SLN | 13 | 22 | L | 6.0 | 7 | 1 | 1 | 0 | 1 | 2 | 84 | 27 | 57 | 68% | 0-5 | 4.11 | 1.14 |
| 2012-08-06 | Yovani Gallardo | R | 26 | L 6-3 | vs CIN | 23 | 138 | W | 7.0 | 6 | 1 | 1 | 1 | 3 | 4 | 107 | 44 | 63 | 59% | 10-8 | 3.79 | 1.31 |
| 2012-08-07 | Mike Fiers | R | 27 | L 3-1 | vs CIN | 12 | 12 | W | 8.0 | 3 | 1 | 1 | 0 | 0 | 7 | 111 | 37 | 74 | 67% | 6-4 | 1.80 | 1.01 |
| 2012-08-08 | Randy Wolf | L | 36 | L 3-2 | vs CIN | 22 | 364 | - | 6.0 | 6 | 2 | 2 | 1 | 2 | 7 | 104 | 40 | 64 | 62% | 3-8 | 5.47 | 1.55 |
| 2012-08-10 | Mark Rogers | R | 27 | L 3-4 | @ HOU | 3 | 5 | - | 7.0 | 3 | 1 | 1 | 0 | 2 | 8 | 108 | 42 | 66 | 61% | 0-1 | 4.00 | 1.11 |
| 2012-08-11 | Marco Estrada | R | 29 | L 5-6 | @ HOU | 14 | 23 | - | 4.0 | 7 | 4 | 4 | 0 | 0 | 3 | 70 | 28 | 42 | 60% | 0-5 | 4.34 | 1.16 |
| 2012-08-12 | Yovani Gallardo | R | 26 | W 5-3 | @ HOU | 24 | 139 | W | 7.2 | 9 | 3 | 3 | 0 | 2 | 8 | 113 | 45 | 68 | 60% | 11-8 | 3.77 | 1.32 |
| 2012-08-13 | Mike Fiers | R | 27 | L 6-9 | @ COL | 13 | 13 | L | 2.0 | 9 | 8 | 8 | 0 | 0 | 1 | 50 | 18 | 32 | 64% | 6-5 | 2.63 | 1.10 |
| 2012-08-14 | Randy Wolf | L | 36 | L 6-8 | @ COL | 23 | 365 | L | 5.0 | 10 | 6 | 6 | 1 | 1 | 1 | 96 | 38 | 58 | 60% | 3-9 | 5.67 | 1.57 |
| 2012-08-15 | Mark Rogers | R | 27 | L 6-7 | @ COL | 4 | 6 | - | 6.0 | 7 | 5 | 5 | 1 | 2 | 4 | 91 | 35 | 56 | 62% | 0-1 | 4.88 | 1.21 |
| 2012-08-16 | Marco Estrada | R | 29 | L 7-4 | vs PHI | 15 | 24 | - | 5.0 | 8 | 4 | 4 | 0 | 3 | 1 | 106 | 42 | 64 | 60% | 0-5 | 4.50 | 1.22 |
| 2012-08-17 | Yovani Gallardo | R | 26 | L 6-2 | vs PHI | 25 | 140 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 9 | 118 | 47 | 71 | 60% | 12-8 | 3.66 | 1.30 |
| 2012-08-18 | Mike Fiers | R | 27 | W 3-4 | vs PHI | 14 | 14 | L | 5.0 | 5 | 4 | 4 | 2 | 4 | 5 | 100 | 41 | 59 | 59% | 6-6 | 2.90 | 1.14 |
| 2012-08-19 | Randy Wolf | L | 36 | W 0-8 | vs PHI | 24 | 366 | L | 7.0 | 10 | 5 | 5 | 1 | 2 | 4 | 103 | 35 | 68 | 66% | 3-10 | 5.70 | 1.58 |
| 2012-08-20 | Mark Rogers | R | 27 | L 9-5 | vs CHN | 5 | 7 | W | 5.0 | 5 | 3 | 3 | 1 | 3 | 7 | 90 | 40 | 50 | 56% | 1-1 | 4.97 | 1.28 |
| 2012-08-21 | Marco Estrada | R | 29 | L 5-2 | vs CHN | 16 | 25 | W | 6.0 | 2 | 0 | 0 | 0 | 1 | 9 | 97 | 34 | 63 | 65% | 1-5 | 4.22 | 1.18 |
| 2012-08-22 | Yovani Gallardo | R | 26 | L 3-2 | vs CHN | 26 | 141 | W | 7.0 | 4 | 2 | 2 | 2 | 2 | 9 | 107 | 42 | 65 | 61% | 13-8 | 3.61 | 1.28 |
| 2012-08-24 | Mike Fiers | R | 27 | W 6-5 | @ PIT | 15 | 15 | W | 6.2 | 5 | 3 | 3 | 1 | 2 | 10 | 111 | 39 | 72 | 65% | 7-6 | 2.97 | 1.13 |
| 2012-08-25 | Shaun Marcum | R | 31 | L 0-4 | @ PIT | 14 | 142 | L | 5.0 | 5 | 4 | 0 | 0 | 1 | 5 | 88 | 26 | 62 | 70% | 5-4 | 3.21 | 1.17 |
| 2012-08-26 | Mark Rogers | R | 27 | W 7-0 | @ PIT | 6 | 8 | W | 5.0 | 3 | 0 | 0 | 0 | 3 | 5 | 99 | 44 | 55 | 56% | 2-1 | 4.24 | 1.26 |
| 2012-08-27 | Marco Estrada | R | 29 | W 15-4 | @ CHN | 17 | 26 | W | 5.0 | 6 | 3 | 0 | 0 | 3 | 8 | 100 | 35 | 65 | 65% | 2-5 | 4.01 | 1.21 |
| 2012-08-28 | Yovani Gallardo | R | 26 | W 4-1 | @ CHN | 27 | 142 | W | 7.0 | 3 | 1 | 1 | 1 | 3 | 9 | 99 | 42 | 57 | 58% | 14-8 | 3.51 | 1.26 |
| 2012-08-29 | Mike Fiers | R | 27 | W 3-1 | @ CHN | 16 | 16 | W | 7.1 | 4 | 1 | 1 | 0 | 1 | 6 | 87 | 33 | 54 | 62% | 8-6 | 2.85 | 1.10 |
| 2012-08-30 | Shaun Marcum | R | 31 | L 11-12 | @ CHN | 15 | 143 | - | 4.0 | 5 | 3 | 3 | 0 | 4 | 4 | 85 | 36 | 49 | 58% | 5-4 | 3.36 | 1.22 |
| 2012-08-31 | Mark Rogers | R | 27 | L 9-3 | vs PIT | 7 | 9 | W | 5.1 | 5 | 1 | 1 | 1 | 2 | 5 | 106 | 39 | 67 | 63% | 3-1 | 3.92 | 1.28 |
| 2012-09-01 | Marco Estrada | R | 29 | L 3-2 | vs PIT | 18 | 27 | - | 7.0 | 4 | 1 | 1 | 1 | 1 | 10 | 100 | 28 | 72 | 72% | 2-5 | 3.83 | 1.18 |
| 2012-09-02 | Yovani Gallardo | R | 27 | L 12-8 | vs PIT | 28 | 143 | - | 4.2 | 11 | 7 | 7 | 2 | 4 | 4 | 119 | 51 | 68 | 57% | 14-8 | 3.80 | 1.32 |
| 2012-09-03 | Mike Fiers | R | 27 | L 3-7 | @ MIA | 17 | 17 | L | 3.1 | 6 | 6 | 4 | 0 | 4 | 4 | 85 | 30 | 55 | 65% | 8-7 | 3.12 | 1.16 |
| 2012-09-04 | Shaun Marcum | R | 31 | W 8-4 | @ MIA | 16 | 144 | - | 5.2 | 7 | 4 | 4 | 2 | 1 | 3 | 86 | 29 | 57 | 66% | 5-4 | 3.53 | 1.23 |
| 2012-09-05 | Wily Peralta | R | 23 | W 8-5 | @ MIA | 1 | 1 | W | 6.0 | 5 | 3 | 3 | 0 | 4 | 3 | 92 | 37 | 55 | 60% | 1-0 | 5.14 | 1.71 |
| 2012-09-06 | Marco Estrada | R | 29 | L 2-6 | @ MIA | 19 | 28 | L | 5.0 | 7 | 4 | 4 | 0 | 0 | 5 | 107 | 33 | 74 | 69% | 2-6 | 3.98 | 1.19 |
| 2012-09-07 | Yovani Gallardo | R | 27 | W 5-4 | @ SLN | 29 | 144 | - | 6.0 | 6 | 2 | 2 | 0 | 0 | 6 | 103 | 42 | 61 | 59% | 14-8 | 3.77 | 1.31 |
| 2012-09-08 | Mike Fiers | R | 27 | W 6-3 | @ SLN | 18 | 18 | W | 5.0 | 5 | 1 | 1 | 0 | 3 | 5 | 95 | 34 | 61 | 64% | 9-7 | 3.06 | 1.18 |
| 2012-09-09 | Shaun Marcum | R | 31 | L 4-5 | @ SLN | 17 | 145 | - | 5.0 | 8 | 4 | 4 | 2 | 0 | 5 | 97 | 38 | 59 | 61% | 5-4 | 3.71 | 1.25 |
| 2012-09-10 | Wily Peralta | R | 23 | L 4-1 | vs ATL | 2 | 2 | - | 6.0 | 7 | 1 | 1 | 0 | 1 | 4 | 93 | 39 | 54 | 58% | 1-0 | 3.46 | 1.54 |
| 2012-09-11 | Marco Estrada | R | 29 | L 5-0 | vs ATL | 20 | 29 | W | 6.2 | 4 | 0 | 0 | 0 | 1 | 6 | 101 | 37 | 64 | 63% | 3-6 | 3.78 | 1.17 |
| 2012-09-12 | Yovani Gallardo | R | 27 | L 8-2 | vs ATL | 30 | 145 | W | 7.0 | 4 | 2 | 2 | 1 | 3 | 6 | 104 | 46 | 58 | 56% | 15-8 | 3.73 | 1.30 |
| 2012-09-14 | Mike Fiers | R | 27 | W 3-7 | vs NYN | 19 | 19 | L | 5.0 | 6 | 4 | 4 | 1 | 2 | 4 | 90 | 31 | 59 | 66% | 9-8 | 3.24 | 1.20 |
| 2012-09-15 | Shaun Marcum | R | 31 | L 9-6 | vs NYN | 18 | 146 | - | 4.0 | 7 | 4 | 4 | 0 | 2 | 3 | 86 | 36 | 50 | 58% | 5-4 | 3.91 | 1.28 |
| 2012-09-16 | Wily Peralta | R | 23 | L 3-0 | vs NYN | 3 | 3 | W | 8.0 | 2 | 0 | 0 | 0 | 1 | 5 | 101 | 35 | 66 | 65% | 2-0 | 2.14 | 1.10 |
| 2012-09-18 | Yovani Gallardo | R | 27 | W 6-0 | @ PIT | 31 | 146 | W | 6.2 | 2 | 0 | 0 | 0 | 4 | 6 | 106 | 42 | 64 | 60% | 16-8 | 3.59 | 1.28 |
| 2012-09-19 | Marco Estrada | R | 29 | W 3-1 | @ PIT | 21 | 30 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 4 | 96 | 28 | 68 | 71% | 4-6 | 3.57 | 1.13 |
| 2012-09-20 | Mike Fiers | R | 27 | W 9-7 | @ PIT | 20 | 20 | - | 3.0 | 5 | 3 | 3 | 1 | 1 | 2 | 86 | 30 | 56 | 65% | 9-8 | 3.38 | 1.22 |
| 2012-09-21 | Shaun Marcum | R | 31 | W 4-2 | @ WAS | 19 | 147 | - | 6.0 | 4 | 2 | 2 | 1 | 0 | 3 | 93 | 35 | 58 | 62% | 5-4 | 3.86 | 1.25 |
| 2012-09-22 | Wily Peralta | R | 23 | L 4-10 | @ WAS | 4 | 4 | L | 2.2 | 5 | 3 | 3 | 0 | 4 | 4 | 77 | 31 | 46 | 60% | 2-1 | 3.00 | 1.33 |
| 2012-09-23 | Yovani Gallardo | R | 27 | W 6-2 | @ WAS | 32 | 147 | - | 5.0 | 6 | 2 | 2 | 0 | 2 | 5 | 98 | 39 | 59 | 60% | 16-8 | 3.59 | 1.29 |
| 2012-09-24 | Marco Estrada | R | 29 | L 2-12 | @ WAS | 22 | 31 | L | 4.0 | 8 | 7 | 6 | 1 | 2 | 3 | 85 | 32 | 53 | 62% | 4-7 | 3.88 | 1.18 |
| 2012-09-25 | Mike Fiers | R | 27 | L 2-4 | @ CIN | 21 | 21 | L | 4.1 | 9 | 4 | 4 | 0 | 2 | 8 | 104 | 35 | 69 | 66% | 9-9 | 3.54 | 1.26 |
| 2012-09-26 | Shaun Marcum | R | 31 | W 8-1 | @ CIN | 20 | 148 | W | 6.0 | 4 | 1 | 1 | 0 | 3 | 7 | 96 | 41 | 55 | 57% | 6-4 | 3.74 | 1.25 |
| 2012-09-27 | Wily Peralta | R | 23 | L 1-2 | @ CIN | 5 | 5 | - | 5.1 | 2 | 0 | 0 | 0 | 1 | 6 | 69 | 26 | 43 | 62% | 2-1 | 2.48 | 1.21 |
| 2012-09-28 | Yovani Gallardo | R | 27 | W 6-7 | vs HOU | 33 | 148 | L | 6.0 | 8 | 5 | 4 | 2 | 3 | 5 | 106 | 37 | 69 | 65% | 16-9 | 3.66 | 1.30 |
| 2012-09-29 | Marco Estrada | R | 29 | L 9-5 | vs HOU | 23 | 32 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 11 | 112 | 37 | 75 | 67% | 5-7 | 3.65 | 1.14 |
| 2012-09-30 | Mike Fiers | R | 27 | W 0-7 | vs HOU | 22 | 22 | L | 6.0 | 6 | 5 | 5 | 4 | 1 | 10 | 105 | 30 | 75 | 71% | 9-10 | 3.73 | 1.26 |
| 2012-10-01 | Shaun Marcum | R | 31 | L 5-3 | vs SDN | 21 | 149 | W | 6.0 | 6 | 2 | 2 | 1 | 4 | 2 | 104 | 46 | 58 | 56% | 7-4 | 3.70 | 1.27 |
| 2012-10-02 | Tyler Thornburg | R | 24 | L 4-3 | vs SDN | 3 | 3 | - | 4.0 | 4 | 1 | 1 | 0 | 0 | 4 | 49 | 17 | 32 | 65% | 0-0 | 4.50 | 1.41 |
| 2012-10-03 | Joshua Stinson | R | 25 | W 6-7 | vs SDN | 1 | 1 | - | 4.0 | 3 | 1 | 1 | 1 | 2 | 0 | 60 | 30 | 30 | 50% | 0-0 | 1.00 | 1.33 |