| Central | W | L | Pct | GB |
| Detroit | 88 | 74 | .543 | -- |
| Chi White Sox | 85 | 77 | .525 | 3.0 |
| KC Royals | 72 | 90 | .444 | 16.0 |
| Cleveland | 68 | 94 | .420 | 20.0 |
| Minnesota | 66 | 96 | .407 | 22.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-06 | Bruce Chen | L | 35 | L 0-5 | @ ANA | 1 | 170 | - | 6.0 | 3 | 0 | 0 | 0 | 0 | 4 | 74 | 21 | 53 | 72% | 0-0 | 0.00 | 0.50 |
| 2012-04-07 | Luke Hochevar | R | 29 | W 6-3 | @ ANA | 1 | 97 | W | 6.1 | 5 | 2 | 2 | 0 | 2 | 4 | 97 | 38 | 59 | 61% | 1-0 | 3.00 | 1.17 |
| 2012-04-08 | Jonathan Sanchez | L | 29 | W 7-3 | @ ANA | 1 | 119 | W | 5.0 | 4 | 2 | 2 | 0 | 3 | 4 | 102 | 43 | 59 | 58% | 1-0 | 3.60 | 1.40 |
| 2012-04-09 | Luis Mendoza | R | 28 | L 0-1 | @ OAK | 1 | 17 | L | 5.2 | 5 | 1 | 1 | 0 | 4 | 2 | 101 | 44 | 57 | 56% | 0-1 | 1.50 | 1.50 |
| 2012-04-10 | Danny Duffy | L | 23 | W 3-0 | @ OAK | 1 | 21 | W | 6.0 | 1 | 0 | 0 | 0 | 4 | 8 | 102 | 41 | 61 | 60% | 1-0 | 0.00 | 0.83 |
| 2012-04-11 | Bruce Chen | L | 35 | L 4-5 | @ OAK | 2 | 171 | - | 5.0 | 4 | 3 | 2 | 1 | 2 | 3 | 102 | 34 | 68 | 67% | 0-0 | 1.64 | 0.82 |
| 2012-04-13 | Luke Hochevar | R | 29 | W 3-8 | vs CLE | 2 | 98 | L | 4.0 | 9 | 7 | 7 | 0 | 1 | 3 | 70 | 22 | 48 | 69% | 1-1 | 8.10 | 1.70 |
| 2012-04-14 | Jonathan Sanchez | L | 29 | W 9-11 | vs CLE | 2 | 120 | - | 2.2 | 6 | 5 | 5 | 0 | 4 | 1 | 74 | 37 | 37 | 50% | 1-0 | 7.88 | 2.13 |
| 2012-04-15 | Luis Mendoza | R | 28 | W 7-13 | vs CLE | 2 | 18 | L | 4.0 | 9 | 9 | 5 | 2 | 4 | 1 | 89 | 38 | 51 | 57% | 0-2 | 5.40 | 2.20 |
| 2012-04-16 | Danny Duffy | L | 23 | W 2-3 | vs DET | 2 | 22 | L | 6.2 | 7 | 3 | 3 | 2 | 1 | 7 | 104 | 32 | 72 | 69% | 1-1 | 2.08 | 1.00 |
| 2012-04-17 | Bruce Chen | L | 35 | W 1-3 | vs DET | 3 | 172 | L | 7.0 | 6 | 2 | 2 | 0 | 0 | 7 | 107 | 30 | 77 | 72% | 0-1 | 2.00 | 0.83 |
| 2012-04-18 | Jonathan Sanchez | L | 29 | W 3-4 | vs DET | 3 | 121 | - | 5.0 | 4 | 2 | 2 | 0 | 3 | 3 | 96 | 37 | 59 | 61% | 1-0 | 6.23 | 1.85 |
| 2012-04-20 | Luke Hochevar | R | 29 | W 3-4 | vs TOR | 3 | 99 | - | 5.0 | 2 | 1 | 1 | 0 | 2 | 5 | 83 | 32 | 51 | 61% | 1-1 | 6.00 | 1.40 |
| 2012-04-21 | Luis Mendoza | R | 28 | W 5-9 | vs TOR | 3 | 19 | - | 3.1 | 10 | 4 | 4 | 0 | 1 | 0 | 50 | 16 | 34 | 68% | 0-2 | 6.92 | 2.54 |
| 2012-04-22 | Danny Duffy | L | 23 | W 3-5 | vs TOR | 3 | 23 | L | 4.2 | 5 | 4 | 4 | 0 | 5 | 5 | 113 | 47 | 66 | 58% | 1-2 | 3.71 | 1.35 |
| 2012-04-23 | Bruce Chen | L | 35 | W 1-4 | vs TOR | 4 | 173 | L | 7.0 | 6 | 3 | 3 | 2 | 2 | 3 | 106 | 38 | 68 | 64% | 0-2 | 2.52 | 0.92 |
| 2012-04-24 | Jonathan Sanchez | L | 29 | L 3-4 | @ CLE | 4 | 122 | L | 4.2 | 4 | 4 | 4 | 0 | 7 | 5 | 113 | 59 | 54 | 48% | 1-1 | 6.88 | 2.06 |
| 2012-04-25 | Luke Hochevar | R | 29 | W 8-2 | @ CLE | 4 | 100 | W | 6.1 | 4 | 2 | 2 | 0 | 3 | 4 | 100 | 43 | 57 | 57% | 2-1 | 4.91 | 1.27 |
| 2012-04-26 | Luis Mendoza | R | 28 | W 4-2 | @ CLE | 4 | 20 | W | 5.0 | 4 | 2 | 2 | 0 | 2 | 3 | 71 | 29 | 42 | 59% | 1-2 | 6.00 | 2.17 |
| 2012-04-27 | Everett Teaford | L | 28 | W 7-6 | @ MIN | 1 | 4 | - | 4.0 | 8 | 4 | 4 | 1 | 2 | 1 | 74 | 29 | 45 | 61% | 0-1 | 5.73 | 1.64 |
| 2012-04-29 | Bruce Chen | L | 35 | L 4-7 | @ MIN | 5 | 174 | L | 2.2 | 6 | 6 | 6 | 0 | 2 | 1 | 61 | 25 | 36 | 59% | 0-3 | 4.18 | 1.11 |
| 2012-05-01 | Luke Hochevar | R | 29 | L 3-9 | @ DET | 5 | 101 | L | 4.0 | 12 | 9 | 9 | 0 | 3 | 2 | 76 | 26 | 50 | 66% | 2-2 | 7.27 | 1.65 |
| 2012-05-02 | Jonathan Sanchez | L | 29 | W 3-2 | @ DET | 5 | 123 | - | 5.0 | 1 | 0 | 0 | 0 | 2 | 2 | 81 | 39 | 42 | 52% | 1-1 | 5.32 | 1.73 |
| 2012-05-03 | Danny Duffy | L | 23 | L 4-3 | vs NYA | 4 | 24 | W | 5.1 | 6 | 2 | 2 | 0 | 2 | 6 | 90 | 38 | 52 | 58% | 2-2 | 3.52 | 1.35 |
| 2012-05-04 | Bruce Chen | L | 35 | W 2-6 | vs NYA | 6 | 175 | L | 6.2 | 9 | 6 | 6 | 2 | 1 | 4 | 92 | 32 | 60 | 65% | 0-4 | 5.03 | 1.21 |
| 2012-05-05 | Felipe Paulino | R | 29 | L 5-1 | vs NYA | 1 | 55 | W | 6.0 | 4 | 0 | 0 | 0 | 2 | 6 | 94 | 37 | 57 | 61% | 1-0 | 0.00 | 1.00 |
| 2012-05-06 | Luke Hochevar | R | 29 | W 4-10 | vs NYA | 6 | 102 | L | 2.1 | 7 | 7 | 7 | 2 | 1 | 0 | 51 | 21 | 30 | 59% | 2-3 | 9.00 | 1.82 |
| 2012-05-07 | Jonathan Sanchez | L | 29 | W 5-11 | vs BOS | 6 | 124 | L | 3.0 | 6 | 6 | 6 | 2 | 3 | 3 | 73 | 38 | 35 | 48% | 1-2 | 6.84 | 1.88 |
| 2012-05-08 | Danny Duffy | L | 23 | L 6-4 | vs BOS | 5 | 25 | - | 4.1 | 7 | 4 | 3 | 0 | 5 | 1 | 102 | 46 | 56 | 55% | 2-2 | 4.00 | 1.59 |
| 2012-05-09 | Bruce Chen | L | 35 | L 4-3 | vs BOS | 7 | 176 | W | 6.2 | 7 | 3 | 3 | 0 | 0 | 5 | 103 | 35 | 68 | 66% | 1-4 | 4.83 | 1.17 |
| 2012-05-11 | Felipe Paulino | R | 29 | L 0-5 | @ CHA | 2 | 56 | L | 5.2 | 7 | 4 | 4 | 1 | 1 | 6 | 117 | 46 | 71 | 61% | 1-1 | 3.00 | 1.17 |
| 2012-05-12 | Luke Hochevar | R | 29 | W 5-0 | @ CHA | 7 | 103 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 5 | 103 | 45 | 58 | 56% | 3-3 | 7.20 | 1.57 |
| 2012-05-13 | Danny Duffy | L | 23 | W 9-1 | @ CHA | 6 | 26 | - | 0.2 | 0 | 0 | 0 | 0 | 1 | 1 | 13 | 5 | 8 | 62% | 2-2 | 3.86 | 1.57 |
| 2012-05-14 | Bruce Chen | L | 35 | W 3-1 | @ TEX | 8 | 177 | W | 6.2 | 5 | 1 | 1 | 1 | 2 | 7 | 106 | 39 | 67 | 63% | 2-4 | 4.31 | 1.15 |
| 2012-05-15 | Vincent Mazzaro | R | 26 | W 7-4 | @ TEX | 1 | 40 | W | 5.0 | 7 | 3 | 3 | 0 | 1 | 2 | 86 | 31 | 55 | 64% | 1-0 | 4.50 | 1.33 |
| 2012-05-16 | Felipe Paulino | R | 29 | W 3-4 | vs BAL | 3 | 57 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 9 | 103 | 36 | 67 | 65% | 1-1 | 1.89 | 1.11 |
| 2012-05-17 | Luke Hochevar | R | 29 | W 3-5 | vs BAL | 8 | 104 | L | 6.0 | 7 | 4 | 4 | 1 | 1 | 6 | 98 | 37 | 61 | 62% | 3-4 | 7.02 | 1.54 |
| 2012-05-18 | Luis Mendoza | R | 29 | W 4-6 | vs ARI | 5 | 21 | - | 5.2 | 5 | 4 | 4 | 0 | 3 | 4 | 93 | 38 | 55 | 59% | 2-2 | 5.03 | 1.88 |
| 2012-05-19 | Bruce Chen | L | 35 | L 7-3 | vs ARI | 9 | 178 | W | 6.1 | 8 | 2 | 2 | 0 | 2 | 4 | 100 | 33 | 67 | 67% | 3-4 | 4.17 | 1.20 |
| 2012-05-20 | Nathan Adcock | R | 24 | W 0-2 | vs ARI | 1 | 4 | L | 5.0 | 5 | 1 | 1 | 0 | 1 | 3 | 77 | 31 | 46 | 60% | 0-2 | 2.37 | 1.47 |
| 2012-05-21 | Felipe Paulino | R | 29 | W 6-0 | @ NYA | 4 | 58 | W | 6.2 | 6 | 0 | 0 | 0 | 2 | 8 | 109 | 46 | 63 | 58% | 2-1 | 1.44 | 1.16 |
| 2012-05-22 | Luke Hochevar | R | 29 | L 2-3 | @ NYA | 9 | 105 | L | 6.2 | 6 | 3 | 3 | 1 | 3 | 8 | 115 | 47 | 68 | 59% | 3-5 | 6.56 | 1.50 |
| 2012-05-23 | Will Smith | L | 23 | L 3-8 | @ NYA | 1 | 1 | L | 3.1 | 6 | 5 | 5 | 3 | 1 | 1 | 54 | 24 | 30 | 56% | 0-1 | 15.00 | 2.33 |
| 2012-05-25 | Bruce Chen | L | 35 | L 2-8 | @ BAL | 10 | 179 | L | 4.0 | 7 | 6 | 6 | 0 | 2 | 2 | 84 | 28 | 56 | 67% | 3-5 | 4.81 | 1.28 |
| 2012-05-26 | Felipe Paulino | R | 29 | W 4-3 | @ BAL | 5 | 59 | - | 5.2 | 5 | 3 | 3 | 2 | 5 | 5 | 111 | 51 | 60 | 54% | 2-1 | 2.03 | 1.26 |
| 2012-05-27 | Luke Hochevar | R | 29 | W 4-2 | @ BAL | 10 | 106 | - | 4.2 | 7 | 2 | 1 | 0 | 1 | 6 | 107 | 38 | 69 | 64% | 3-5 | 6.23 | 1.54 |
| 2012-05-28 | Nathan Adcock | R | 24 | L 5-8 | @ CLE | 2 | 5 | L | 2.1 | 6 | 5 | 4 | 1 | 2 | 0 | 51 | 23 | 28 | 55% | 0-3 | 3.68 | 1.64 |
| 2012-05-29 | Will Smith | L | 23 | W 8-2 | @ CLE | 2 | 2 | W | 6.0 | 4 | 2 | 2 | 0 | 2 | 5 | 98 | 33 | 65 | 66% | 1-1 | 7.00 | 1.44 |
| 2012-05-30 | Bruce Chen | L | 35 | W 6-3 | @ CLE | 11 | 180 | W | 5.0 | 7 | 3 | 3 | 0 | 2 | 3 | 104 | 44 | 60 | 58% | 4-5 | 4.86 | 1.32 |
| 2012-06-01 | Felipe Paulino | R | 29 | L 2-0 | vs OAK | 6 | 60 | W | 6.0 | 3 | 0 | 0 | 0 | 3 | 5 | 90 | 37 | 53 | 59% | 3-1 | 1.70 | 1.22 |
| 2012-06-02 | Luke Hochevar | R | 29 | W 3-9 | vs OAK | 11 | 107 | L | 4.2 | 5 | 6 | 6 | 0 | 3 | 3 | 90 | 40 | 50 | 56% | 3-6 | 6.63 | 1.54 |
| 2012-06-03 | Vincent Mazzaro | R | 26 | L 2-0 | vs OAK | 2 | 41 | W | 6.0 | 4 | 0 | 0 | 0 | 3 | 3 | 95 | 39 | 56 | 59% | 2-0 | 2.25 | 1.25 |
| 2012-06-04 | Will Smith | L | 23 | W 7-10 | vs MIN | 3 | 3 | L | 4.2 | 8 | 7 | 7 | 3 | 2 | 3 | 80 | 28 | 52 | 65% | 1-2 | 9.00 | 1.64 |
| 2012-06-05 | Bruce Chen | L | 35 | L 1-0 | vs MIN | 12 | 181 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 5 | 88 | 26 | 62 | 70% | 5-5 | 4.37 | 1.24 |
| 2012-06-06 | Felipe Paulino | R | 29 | W 2-4 | vs MIN | 7 | 61 | - | 0.2 | 1 | 1 | 0 | 0 | 0 | 0 | 13 | 5 | 8 | 62% | 3-1 | 1.66 | 1.21 |
| 2012-06-08 | Luke Hochevar | R | 29 | L 2-4 | @ PIT | 12 | 108 | L | 6.0 | 9 | 4 | 4 | 0 | 1 | 3 | 102 | 41 | 61 | 60% | 3-7 | 6.57 | 1.56 |
| 2012-06-09 | Vincent Mazzaro | R | 26 | L 3-5 | @ PIT | 3 | 42 | L | 3.0 | 3 | 4 | 3 | 0 | 4 | 4 | 80 | 37 | 43 | 54% | 2-1 | 3.60 | 1.47 |
| 2012-06-10 | Bruce Chen | L | 35 | L 2-3 | @ PIT | 13 | 182 | L | 5.0 | 4 | 3 | 3 | 1 | 1 | 5 | 84 | 25 | 59 | 70% | 5-6 | 4.44 | 1.23 |
| 2012-06-12 | Luis Mendoza | R | 29 | L 2-1 | vs MIL | 6 | 22 | - | 6.0 | 1 | 1 | 1 | 0 | 2 | 4 | 73 | 28 | 45 | 62% | 2-3 | 4.86 | 1.64 |
| 2012-06-13 | Jonathan Sanchez | L | 30 | L 4-3 | vs MIL | 7 | 125 | - | 5.0 | 7 | 1 | 1 | 0 | 2 | 4 | 96 | 32 | 64 | 67% | 1-2 | 6.00 | 1.87 |
| 2012-06-14 | Luke Hochevar | R | 29 | L 4-3 | vs MIL | 13 | 109 | - | 7.1 | 6 | 3 | 3 | 2 | 1 | 5 | 86 | 25 | 61 | 71% | 3-7 | 6.30 | 1.50 |
| 2012-06-15 | Vincent Mazzaro | R | 26 | W 3-2 | @ SLN | 4 | 43 | W | 6.0 | 5 | 0 | 0 | 0 | 1 | 4 | 86 | 28 | 58 | 67% | 3-1 | 2.57 | 1.33 |
| 2012-06-16 | Bruce Chen | L | 35 | L 7-10 | @ SLN | 14 | 183 | - | 1.2 | 7 | 6 | 6 | 2 | 0 | 0 | 40 | 13 | 27 | 68% | 5-6 | 5.03 | 1.29 |
| 2012-06-17 | Luis Mendoza | R | 29 | W 5-3 | @ SLN | 7 | 23 | - | 6.0 | 6 | 2 | 2 | 2 | 1 | 5 | 92 | 33 | 59 | 64% | 2-3 | 4.66 | 1.59 |
| 2012-06-18 | Jonathan Sanchez | L | 30 | L 7-9 | @ HOU | 8 | 126 | L | 6.0 | 6 | 4 | 3 | 1 | 4 | 3 | 110 | 48 | 62 | 56% | 1-3 | 5.75 | 1.83 |
| 2012-06-19 | Luke Hochevar | R | 29 | W 2-0 | @ HOU | 14 | 110 | W | 7.2 | 5 | 0 | 0 | 0 | 4 | 6 | 92 | 35 | 57 | 62% | 4-7 | 5.65 | 1.46 |
| 2012-06-20 | Bruce Chen | L | 35 | W 2-1 | @ HOU | 15 | 184 | W | 5.2 | 5 | 1 | 1 | 0 | 2 | 6 | 92 | 35 | 57 | 62% | 6-6 | 4.83 | 1.29 |
| 2012-06-22 | Vincent Mazzaro | R | 26 | W 4-11 | vs SLN | 5 | 44 | L | 1.1 | 6 | 7 | 7 | 0 | 2 | 2 | 42 | 16 | 26 | 62% | 3-2 | 5.32 | 1.64 |
| 2012-06-23 | Luis Mendoza | R | 29 | W 2-8 | vs SLN | 8 | 24 | L | 4.1 | 7 | 4 | 4 | 0 | 2 | 2 | 84 | 35 | 49 | 58% | 2-4 | 4.95 | 1.63 |
| 2012-06-24 | Jonathan Sanchez | L | 30 | W 8-11 | vs SLN | 9 | 127 | - | 5.2 | 4 | 6 | 6 | 2 | 6 | 3 | 109 | 50 | 59 | 54% | 1-3 | 6.21 | 1.81 |
| 2012-06-25 | Luke Hochevar | R | 29 | L 8-0 | vs TBA | 15 | 111 | W | 9.0 | 7 | 0 | 0 | 0 | 1 | 8 | 112 | 40 | 72 | 64% | 5-7 | 5.07 | 1.40 |
| 2012-06-26 | Bruce Chen | L | 35 | L 8-2 | vs TBA | 16 | 185 | W | 7.0 | 5 | 2 | 1 | 1 | 1 | 5 | 99 | 27 | 72 | 73% | 7-6 | 4.55 | 1.26 |
| 2012-06-27 | Everett Teaford | L | 28 | L 5-4 | vs TBA | 2 | 5 | - | 5.0 | 4 | 2 | 2 | 0 | 3 | 5 | 88 | 34 | 54 | 61% | 0-1 | 5.06 | 1.56 |
| 2012-06-29 | Luis Mendoza | R | 29 | W 4-3 | @ MIN | 9 | 25 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 5 | 117 | 46 | 71 | 61% | 3-4 | 4.50 | 1.51 |
| 2012-06-30 | Jonathan Sanchez | L | 30 | L 2-7 | @ MIN | 10 | 128 | L | 4.1 | 10 | 6 | 6 | 0 | 6 | 4 | 105 | 49 | 56 | 53% | 1-4 | 6.85 | 2.00 |
| 2012-06-30 | Luke Hochevar | R | 29 | L 1-5 | @ MIN | 16 | 112 | L | 6.0 | 8 | 5 | 5 | 3 | 1 | 0 | 95 | 33 | 62 | 65% | 5-8 | 5.23 | 1.41 |
| 2012-07-01 | Bruce Chen | L | 35 | L 8-10 | @ MIN | 17 | 186 | L | 5.2 | 6 | 6 | 6 | 3 | 1 | 5 | 95 | 29 | 66 | 69% | 7-7 | 4.83 | 1.25 |
| 2012-07-02 | Everett Teaford | L | 28 | W 11-3 | @ TOR | 3 | 6 | W | 7.0 | 5 | 3 | 3 | 2 | 2 | 2 | 102 | 38 | 64 | 63% | 1-1 | 4.70 | 1.39 |
| 2012-07-03 | Vincent Mazzaro | R | 26 | L 3-6 | @ TOR | 6 | 45 | L | 5.1 | 13 | 6 | 6 | 1 | 0 | 3 | 80 | 25 | 55 | 69% | 3-3 | 5.70 | 1.70 |
| 2012-07-04 | Luis Mendoza | R | 29 | L 1-4 | @ TOR | 10 | 26 | L | 6.0 | 9 | 3 | 3 | 0 | 1 | 9 | 101 | 36 | 65 | 64% | 3-5 | 4.50 | 1.53 |
| 2012-07-05 | Luke Hochevar | R | 29 | W 9-6 | @ TOR | 17 | 113 | W | 5.0 | 4 | 2 | 2 | 1 | 1 | 3 | 81 | 28 | 53 | 65% | 6-8 | 5.14 | 1.39 |
| 2012-07-06 | Jonathan Sanchez | L | 30 | L 2-4 | @ DET | 11 | 129 | L | 5.2 | 6 | 4 | 4 | 1 | 3 | 2 | 101 | 41 | 60 | 59% | 1-5 | 6.75 | 1.94 |
| 2012-07-07 | Bruce Chen | L | 35 | L 7-8 | @ DET | 18 | 187 | L | 3.1 | 9 | 6 | 6 | 1 | 2 | 3 | 72 | 22 | 50 | 69% | 7-8 | 5.23 | 1.33 |
| 2012-07-08 | Everett Teaford | L | 28 | L 1-7 | @ DET | 4 | 7 | L | 4.1 | 7 | 5 | 5 | 2 | 1 | 5 | 80 | 29 | 51 | 64% | 1-2 | 5.67 | 1.48 |
| 2012-07-13 | Bruce Chen | L | 35 | W 8-9 | vs CHA | 19 | 188 | - | 4.2 | 9 | 6 | 6 | 3 | 3 | 5 | 110 | 38 | 72 | 65% | 7-8 | 5.50 | 1.38 |
| 2012-07-14 | Luke Hochevar | R | 29 | L 6-3 | vs CHA | 18 | 114 | - | 5.0 | 5 | 3 | 3 | 1 | 3 | 4 | 97 | 42 | 55 | 57% | 6-8 | 5.16 | 1.40 |
| 2012-07-15 | Luis Mendoza | R | 29 | W 1-2 | vs CHA | 11 | 27 | L | 7.1 | 4 | 2 | 2 | 1 | 4 | 6 | 93 | 41 | 52 | 56% | 3-6 | 4.33 | 1.49 |
| 2012-07-16 | Jonathan Sanchez | L | 30 | W 4-9 | vs SEA | 12 | 130 | L | 1.1 | 7 | 7 | 7 | 2 | 1 | 2 | 50 | 20 | 30 | 60% | 1-6 | 7.81 | 2.06 |
| 2012-07-17 | Ryan Verdugo | L | 25 | W 6-9 | vs SEA | 1 | 1 | L | 1.2 | 8 | 6 | 6 | 1 | 2 | 2 | 55 | 24 | 31 | 56% | 0-1 | 27.00 | 5.00 |
| 2012-07-18 | Bruce Chen | L | 35 | L 8-7 | vs SEA | 20 | 189 | - | 5.1 | 7 | 4 | 4 | 2 | 0 | 6 | 103 | 32 | 71 | 69% | 7-8 | 5.58 | 1.38 |
| 2012-07-19 | Will Smith | L | 23 | W 1-6 | vs SEA | 4 | 4 | L | 6.1 | 8 | 4 | 4 | 1 | 2 | 5 | 90 | 31 | 59 | 66% | 1-3 | 8.10 | 1.65 |
| 2012-07-20 | Luke Hochevar | R | 29 | W 1-2 | vs MIN | 19 | 115 | - | 7.0 | 5 | 1 | 1 | 1 | 0 | 6 | 107 | 42 | 65 | 61% | 6-8 | 4.91 | 1.35 |
| 2012-07-21 | Luis Mendoza | R | 29 | L 7-3 | vs MIN | 12 | 28 | W | 6.1 | 7 | 3 | 3 | 0 | 2 | 4 | 93 | 38 | 55 | 59% | 4-6 | 4.30 | 1.48 |
| 2012-07-22 | Jeremy Guthrie | R | 33 | W 5-7 | vs MIN | 16 | 170 | L | 5.0 | 4 | 5 | 5 | 1 | 3 | 4 | 91 | 35 | 56 | 62% | 3-10 | 6.47 | 1.67 |
| 2012-07-23 | Bruce Chen | L | 35 | L 3-6 | @ ANA | 21 | 190 | - | 5.1 | 5 | 3 | 3 | 0 | 2 | 3 | 107 | 38 | 69 | 64% | 7-8 | 5.53 | 1.37 |
| 2012-07-24 | Will Smith | L | 23 | W 4-1 | @ ANA | 5 | 5 | W | 7.0 | 2 | 1 | 1 | 0 | 4 | 4 | 101 | 45 | 56 | 55% | 2-3 | 6.33 | 1.44 |
| 2012-07-25 | Luke Hochevar | R | 29 | L 6-11 | @ ANA | 20 | 116 | L | 3.0 | 9 | 8 | 6 | 1 | 1 | 2 | 67 | 25 | 42 | 63% | 6-9 | 5.26 | 1.41 |
| 2012-07-26 | Luis Mendoza | R | 29 | L 1-4 | @ SEA | 13 | 29 | L | 5.0 | 9 | 4 | 4 | 0 | 3 | 1 | 84 | 32 | 52 | 62% | 4-7 | 4.45 | 1.53 |
| 2012-07-27 | Jeremy Guthrie | R | 33 | L 1-6 | @ SEA | 17 | 171 | L | 5.1 | 11 | 6 | 6 | 2 | 0 | 4 | 105 | 37 | 68 | 65% | 3-11 | 6.68 | 1.69 |
| 2012-07-28 | Bruce Chen | L | 35 | L 3-4 | @ SEA | 22 | 191 | L | 6.0 | 7 | 3 | 3 | 1 | 1 | 5 | 97 | 31 | 66 | 68% | 7-9 | 5.48 | 1.37 |
| 2012-07-29 | Will Smith | L | 23 | L 6-7 | @ SEA | 6 | 6 | - | 6.0 | 7 | 3 | 3 | 0 | 0 | 4 | 85 | 31 | 54 | 64% | 2-3 | 6.00 | 1.39 |
| 2012-07-31 | Luke Hochevar | R | 29 | L 8-3 | vs CLE | 21 | 117 | W | 6.0 | 7 | 3 | 3 | 0 | 3 | 6 | 99 | 40 | 59 | 60% | 7-9 | 5.22 | 1.42 |
| 2012-08-01 | Luis Mendoza | R | 29 | L 5-2 | vs CLE | 14 | 30 | W | 7.1 | 4 | 2 | 2 | 1 | 1 | 3 | 94 | 32 | 62 | 66% | 5-7 | 4.32 | 1.47 |
| 2012-08-02 | Bruce Chen | L | 35 | L 7-6 | vs CLE | 23 | 192 | - | 2.2 | 7 | 4 | 4 | 0 | 1 | 0 | 55 | 19 | 36 | 65% | 7-9 | 5.68 | 1.41 |
| 2012-08-03 | Jeremy Guthrie | R | 33 | W 3-5 | vs TEX | 18 | 172 | L | 6.0 | 6 | 3 | 3 | 0 | 2 | 4 | 100 | 36 | 64 | 64% | 3-12 | 6.56 | 1.67 |
| 2012-08-04 | Will Smith | L | 23 | W 2-4 | vs TEX | 7 | 7 | L | 5.2 | 8 | 4 | 4 | 0 | 3 | 2 | 90 | 35 | 55 | 61% | 2-4 | 6.00 | 1.46 |
| 2012-08-05 | Luke Hochevar | R | 29 | L 7-6 | vs TEX | 22 | 118 | - | 6.0 | 4 | 5 | 1 | 0 | 1 | 4 | 106 | 35 | 71 | 67% | 7-9 | 5.04 | 1.39 |
| 2012-08-06 | Luis Mendoza | R | 29 | L 2-4 | @ CHA | 15 | 31 | L | 7.1 | 7 | 4 | 4 | 2 | 1 | 5 | 103 | 38 | 65 | 63% | 5-8 | 4.37 | 1.45 |
| 2012-08-07 | Bruce Chen | L | 35 | W 5-2 | @ CHA | 24 | 193 | W | 6.2 | 7 | 2 | 2 | 1 | 1 | 2 | 100 | 31 | 69 | 69% | 8-9 | 5.51 | 1.40 |
| 2012-08-08 | Jeremy Guthrie | R | 33 | W 2-1 | @ CHA | 19 | 173 | W | 8.0 | 5 | 0 | 0 | 0 | 0 | 6 | 107 | 31 | 76 | 71% | 4-12 | 6.10 | 1.60 |
| 2012-08-09 | Will Smith | L | 23 | W 8-2 | @ BAL | 8 | 8 | W | 7.0 | 6 | 2 | 2 | 1 | 3 | 5 | 97 | 40 | 57 | 59% | 3-4 | 5.48 | 1.43 |
| 2012-08-10 | Luke Hochevar | R | 29 | L 1-7 | @ BAL | 23 | 119 | L | 5.1 | 7 | 7 | 7 | 3 | 2 | 2 | 90 | 33 | 57 | 63% | 7-10 | 5.33 | 1.41 |
| 2012-08-11 | Luis Mendoza | R | 29 | W 7-3 | @ BAL | 16 | 32 | W | 6.0 | 7 | 3 | 3 | 0 | 2 | 4 | 92 | 40 | 52 | 57% | 6-8 | 4.38 | 1.45 |
| 2012-08-12 | Bruce Chen | L | 35 | L 3-5 | @ BAL | 25 | 194 | L | 5.1 | 4 | 4 | 4 | 2 | 3 | 5 | 96 | 35 | 61 | 64% | 8-10 | 5.57 | 1.40 |
| 2012-08-14 | Jeremy Guthrie | R | 33 | L 5-0 | vs OAK | 20 | 174 | W | 7.0 | 3 | 0 | 0 | 0 | 2 | 8 | 102 | 39 | 63 | 62% | 5-12 | 5.75 | 1.55 |
| 2012-08-15 | Will Smith | L | 23 | L 3-2 | vs OAK | 9 | 9 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 5 | 96 | 35 | 61 | 64% | 4-4 | 5.09 | 1.36 |
| 2012-08-16 | Luke Hochevar | R | 29 | W 0-3 | vs OAK | 24 | 120 | L | 7.0 | 4 | 3 | 3 | 2 | 3 | 5 | 103 | 39 | 64 | 62% | 7-11 | 5.26 | 1.39 |
| 2012-08-17 | Luis Mendoza | R | 29 | L 4-2 | vs CHA | 17 | 33 | W | 7.0 | 4 | 2 | 2 | 1 | 1 | 6 | 80 | 31 | 49 | 61% | 7-8 | 4.28 | 1.41 |
| 2012-08-18 | Bruce Chen | L | 35 | L 9-4 | vs CHA | 26 | 195 | W | 6.0 | 5 | 2 | 2 | 1 | 1 | 5 | 97 | 27 | 70 | 72% | 9-10 | 5.46 | 1.38 |
| 2012-08-19 | Jeremy Guthrie | R | 33 | L 5-2 | vs CHA | 21 | 175 | - | 7.2 | 2 | 2 | 0 | 0 | 1 | 5 | 101 | 33 | 68 | 67% | 5-12 | 5.40 | 1.48 |
| 2012-08-20 | Will Smith | L | 23 | L 1-5 | @ TBA | 10 | 10 | L | 3.2 | 8 | 4 | 4 | 0 | 2 | 4 | 78 | 33 | 45 | 58% | 4-5 | 5.37 | 1.44 |
| 2012-08-21 | Luke Hochevar | R | 29 | W 1-0 | @ TBA | 25 | 121 | - | 8.0 | 1 | 0 | 0 | 0 | 3 | 10 | 107 | 42 | 65 | 61% | 7-11 | 4.97 | 1.34 |
| 2012-08-22 | Luis Mendoza | R | 29 | L 3-5 | @ TBA | 18 | 34 | L | 4.1 | 5 | 2 | 2 | 0 | 4 | 0 | 84 | 41 | 43 | 51% | 7-9 | 4.25 | 1.42 |
| 2012-08-24 | Bruce Chen | L | 35 | L 3-4 | @ BOS | 27 | 196 | - | 6.0 | 8 | 3 | 3 | 0 | 1 | 5 | 100 | 35 | 65 | 65% | 9-10 | 5.42 | 1.38 |
| 2012-08-25 | Jeremy Guthrie | R | 33 | W 10-9 | @ BOS | 22 | 176 | - | 2.2 | 7 | 7 | 6 | 2 | 2 | 1 | 51 | 21 | 30 | 59% | 5-12 | 5.73 | 1.52 |
| 2012-08-26 | Will Smith | L | 23 | L 6-8 | @ BOS | 11 | 11 | L | 5.0 | 9 | 5 | 4 | 1 | 2 | 1 | 93 | 34 | 59 | 63% | 4-6 | 5.52 | 1.50 |
| 2012-08-27 | Luke Hochevar | R | 29 | L 1-5 | @ BOS | 26 | 122 | L | 8.0 | 8 | 5 | 4 | 1 | 1 | 6 | 114 | 36 | 78 | 68% | 7-12 | 4.94 | 1.33 |
| 2012-08-28 | Luis Mendoza | R | 29 | L 9-8 | vs DET | 19 | 35 | - | 5.0 | 7 | 6 | 6 | 1 | 1 | 4 | 82 | 32 | 50 | 61% | 7-9 | 4.50 | 1.43 |
| 2012-08-29 | Bruce Chen | L | 35 | L 1-0 | vs DET | 28 | 197 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 4 | 99 | 35 | 64 | 65% | 10-10 | 5.14 | 1.34 |
| 2012-08-30 | Jeremy Guthrie | R | 33 | L 2-1 | vs DET | 23 | 177 | W | 7.1 | 10 | 1 | 1 | 0 | 0 | 3 | 99 | 30 | 69 | 70% | 6-12 | 5.46 | 1.51 |
| 2012-09-01 | Will Smith | L | 23 | W 1-3 | vs MIN | 12 | 12 | L | 6.0 | 9 | 3 | 3 | 0 | 2 | 4 | 92 | 34 | 58 | 63% | 4-7 | 5.43 | 1.53 |
| 2012-09-01 | Luke Hochevar | R | 29 | W 7-8 | vs MIN | 27 | 123 | L | 1.2 | 6 | 8 | 8 | 2 | 4 | 3 | 62 | 29 | 33 | 53% | 7-13 | 5.34 | 1.37 |
| 2012-09-02 | Luis Mendoza | R | 29 | L 6-4 | vs MIN | 20 | 36 | - | 5.0 | 7 | 2 | 2 | 1 | 0 | 3 | 83 | 35 | 48 | 58% | 7-9 | 4.47 | 1.43 |
| 2012-09-03 | Bruce Chen | L | 35 | W 4-8 | vs TEX | 29 | 198 | L | 6.0 | 6 | 6 | 6 | 4 | 1 | 5 | 101 | 30 | 71 | 70% | 10-11 | 5.29 | 1.34 |
| 2012-09-04 | Jeremy Guthrie | R | 33 | L 6-3 | vs TEX | 24 | 178 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 5 | 102 | 38 | 64 | 63% | 7-12 | 5.33 | 1.48 |
| 2012-09-05 | Everett Teaford | L | 28 | W 6-7 | vs TEX | 5 | 8 | L | 4.1 | 3 | 3 | 3 | 1 | 2 | 5 | 71 | 26 | 45 | 63% | 1-4 | 4.42 | 1.33 |
| 2012-09-06 | Luke Hochevar | R | 29 | W 4-5 | vs TEX | 28 | 124 | - | 6.1 | 6 | 4 | 4 | 2 | 2 | 5 | 99 | 34 | 65 | 66% | 7-13 | 5.37 | 1.37 |
| 2012-09-07 | Luis Mendoza | R | 29 | W 7-5 | @ CHA | 21 | 37 | - | 5.1 | 10 | 5 | 5 | 3 | 1 | 3 | 93 | 30 | 63 | 68% | 7-9 | 4.63 | 1.46 |
| 2012-09-08 | Bruce Chen | L | 35 | L 4-5 | @ CHA | 30 | 199 | L | 6.0 | 6 | 5 | 5 | 3 | 2 | 6 | 101 | 33 | 68 | 67% | 10-12 | 5.37 | 1.34 |
| 2012-09-09 | Jeremy Guthrie | R | 33 | W 2-1 | @ CHA | 25 | 179 | - | 8.0 | 6 | 0 | 0 | 0 | 0 | 4 | 101 | 31 | 70 | 69% | 7-12 | 5.05 | 1.45 |
| 2012-09-11 | Will Smith | L | 23 | W 9-1 | @ MIN | 13 | 13 | W | 7.0 | 7 | 0 | 0 | 0 | 3 | 7 | 116 | 44 | 72 | 62% | 5-7 | 4.92 | 1.52 |
| 2012-09-12 | Luke Hochevar | R | 29 | W 10-5 | @ MIN | 29 | 125 | W | 5.0 | 6 | 5 | 5 | 0 | 4 | 4 | 108 | 44 | 64 | 59% | 8-13 | 5.48 | 1.39 |
| 2012-09-13 | Luis Mendoza | R | 29 | L 3-4 | @ MIN | 22 | 38 | - | 6.0 | 2 | 1 | 1 | 1 | 2 | 6 | 96 | 40 | 56 | 58% | 7-9 | 4.50 | 1.42 |
| 2012-09-14 | Bruce Chen | L | 35 | W 7-9 | vs ANA | 31 | 200 | - | 6.1 | 7 | 5 | 5 | 0 | 1 | 5 | 105 | 35 | 70 | 67% | 10-12 | 5.41 | 1.33 |
| 2012-09-15 | Jeremy Guthrie | R | 33 | L 3-2 | vs ANA | 26 | 180 | - | 8.0 | 5 | 2 | 2 | 1 | 1 | 2 | 106 | 36 | 70 | 66% | 7-12 | 4.91 | 1.41 |
| 2012-09-16 | Will Smith | L | 23 | W 3-4 | vs ANA | 14 | 14 | L | 5.0 | 7 | 4 | 4 | 1 | 2 | 2 | 81 | 36 | 45 | 56% | 5-8 | 5.06 | 1.54 |
| 2012-09-18 | Luke Hochevar | R | 29 | W 2-3 | vs CHA | 30 | 126 | L | 7.0 | 7 | 3 | 3 | 3 | 0 | 4 | 98 | 35 | 63 | 64% | 8-14 | 5.41 | 1.38 |
| 2012-09-19 | Bruce Chen | L | 35 | L 3-0 | vs CHA | 32 | 201 | W | 6.2 | 5 | 0 | 0 | 0 | 3 | 4 | 114 | 39 | 75 | 66% | 11-12 | 5.23 | 1.33 |
| 2012-09-20 | Jeremy Guthrie | R | 33 | L 4-3 | vs CHA | 27 | 181 | - | 6.0 | 8 | 3 | 1 | 0 | 1 | 4 | 106 | 37 | 69 | 65% | 7-12 | 4.79 | 1.41 |
| 2012-09-21 | Luis Mendoza | R | 29 | L 6-3 | vs CLE | 23 | 39 | W | 6.0 | 8 | 2 | 2 | 0 | 2 | 3 | 90 | 38 | 52 | 58% | 8-9 | 4.44 | 1.43 |
| 2012-09-22 | Will Smith | L | 23 | L 5-3 | vs CLE | 15 | 15 | W | 7.0 | 8 | 2 | 2 | 1 | 2 | 5 | 102 | 41 | 61 | 60% | 6-8 | 4.86 | 1.53 |
| 2012-09-23 | Jake Odorizzi | R | 22 | W 4-15 | vs CLE | 1 | 1 | L | 5.1 | 6 | 3 | 3 | 1 | 1 | 3 | 87 | 32 | 55 | 63% | 0-1 | 5.40 | 1.40 |
| 2012-09-24 | Luke Hochevar | R | 29 | L 2-6 | @ DET | 31 | 127 | L | 7.1 | 12 | 6 | 5 | 1 | 1 | 5 | 104 | 37 | 67 | 64% | 8-15 | 5.42 | 1.39 |
| 2012-09-25 | Bruce Chen | L | 35 | L 0-2 | @ DET | 33 | 202 | L | 6.2 | 10 | 2 | 2 | 0 | 3 | 5 | 119 | 40 | 79 | 66% | 11-13 | 5.13 | 1.35 |
| 2012-09-26 | Jeremy Guthrie | R | 33 | L 4-5 | @ DET | 28 | 182 | - | 7.0 | 7 | 4 | 4 | 2 | 2 | 3 | 100 | 37 | 63 | 63% | 7-12 | 4.81 | 1.41 |
| 2012-09-27 | Luis Mendoza | R | 29 | L 4-5 | @ DET | 24 | 40 | - | 7.0 | 7 | 4 | 2 | 0 | 1 | 6 | 90 | 31 | 59 | 66% | 8-9 | 4.36 | 1.42 |
| 2012-09-28 | Will Smith | L | 23 | L 5-8 | @ CLE | 16 | 16 | L | 3.0 | 9 | 6 | 6 | 0 | 2 | 2 | 70 | 29 | 41 | 59% | 6-9 | 5.30 | 1.60 |
| 2012-09-29 | Jake Odorizzi | R | 23 | W 7-6 | @ CLE | 2 | 2 | - | 2.0 | 2 | 1 | 1 | 0 | 3 | 1 | 69 | 23 | 46 | 67% | 0-1 | 5.14 | 1.71 |
| 2012-09-30 | Luke Hochevar | R | 29 | L 3-15 | @ CLE | 32 | 128 | L | 4.2 | 9 | 9 | 9 | 0 | 3 | 7 | 103 | 36 | 67 | 65% | 8-16 | 5.74 | 1.42 |
| 2012-10-01 | Bruce Chen | L | 35 | W 3-6 | vs DET | 34 | 203 | L | 5.2 | 10 | 6 | 2 | 2 | 1 | 3 | 90 | 35 | 55 | 61% | 11-14 | 5.06 | 1.36 |
| 2012-10-02 | Jeremy Guthrie | R | 33 | L 4-2 | vs DET | 29 | 183 | W | 6.0 | 5 | 2 | 2 | 0 | 3 | 3 | 100 | 39 | 61 | 61% | 8-12 | 4.75 | 1.41 |
| 2012-10-03 | Luis Mendoza | R | 29 | W 0-1 | vs DET | 25 | 41 | L | 7.0 | 6 | 1 | 1 | 0 | 3 | 6 | 109 | 45 | 64 | 59% | 8-10 | 4.23 | 1.42 |