| 2012-04-06 | @ ANA | 1 | L 0-5 | 0-1 | 3 | 44,106 | Bruce Chen | Jered Weaver | Jered Weaver | Aaron Crow | | 0 | 5 | -5 |
| 2012-04-07 | @ ANA | 2 | W 6-3 | 1-1 | 3 | 40,022 | Luke Hochevar | Dan Haren | Luke Hochevar | Dan Haren | | 6 | 8 | -2 |
| 2012-04-08 | @ ANA | 3 | W 7-3 | 2-1 | 2 | 32,227 | Jonathan Sanchez | Ervin Santana | Jonathan Sanchez | Ervin Santana | Jonathan Broxton | 13 | 11 | 2 |
| 2012-04-09 | @ OAK | 4 | L 0-1 | 2-2 | 3 | 10,054 | Luis Mendoza | Tom Milone | Tom Milone | Luis Mendoza | Grant Balfour | 13 | 12 | 1 |
| 2012-04-10 | @ OAK | 5 | W 3-0 | 3-2 | 2 | 10,670 | Danny Duffy | Graham Godfrey | Danny Duffy | Graham Godfrey | Aaron Crow | 16 | 12 | 4 |
| 2012-04-11 | @ OAK | 6 | L 4-5 | 3-3 | 2 | 12,390 | Bruce Chen | Brandon McCarthy | Andrew Carignan | Jonathan Broxton | | 20 | 17 | 3 |
| 2012-04-13 | vs CLE | 7 | L 3-8 | 3-4 | 4 | 40,230 | Luke Hochevar | Derek Lowe | Derek Lowe | Luke Hochevar | | 23 | 25 | -2 |
| 2012-04-14 | vs CLE | 8 | W 9-11 | 4-4 | 3 | 21,788 | Jonathan Sanchez | Jeanmar Gomez | Luis Valdez | Greg Holland | Chris Perez | 32 | 36 | -4 |
| 2012-04-15 | vs CLE | 9 | W 7-13 | 5-4 | 2 | 21,182 | Luis Mendoza | Ubaldo Jimenez | Ubaldo Jimenez | Luis Mendoza | | 39 | 49 | -10 |
| 2012-04-16 | vs DET | 10 | L 2-3 | 5-5 | 3 | 14,039 | Danny Duffy | Justin Verlander | Justin Verlander | Danny Duffy | | 41 | 52 | -11 |
| 2012-04-17 | vs DET | 11 | L 1-3 | 5-6 | 3 | 13,851 | Bruce Chen | Drew Smyly | Octavio Dotel | Bruce Chen | Jose Valverde | 42 | 55 | -13 |
| 2012-04-18 | vs DET | 12 | L 3-4 | 5-7 | 3 | 14,083 | Jonathan Sanchez | Max Scherzer | Max Scherzer | Jose Mijares | Jose Valverde | 45 | 59 | -14 |
| 2012-04-20 | vs TOR | 13 | L 3-4 | 5-8 | 4 | 23,065 | Luke Hochevar | Kyle Drabek | Luis Perez | Greg Holland | Sergio Santos | 48 | 63 | -15 |
| 2012-04-21 | vs TOR | 14 | L 5-9 | 5-9 | 5 | 27,804 | Luis Mendoza | Drew Hutchison | Drew Hutchison | Everett Teaford | | 53 | 72 | -19 |
| 2012-04-22 | vs TOR | 15 | L 3-5 | 5-10 | 4 | 26,891 | Danny Duffy | Ricky Romero | Ricky Romero | Danny Duffy | Francisco Cordero | 56 | 77 | -21 |
| 2012-04-23 | vs TOR | 16 | L 1-4 | 5-11 | 4 | 13,267 | Bruce Chen | Brandon Morrow | Brandon Morrow | Bruce Chen | Francisco Cordero | 57 | 81 | -24 |
| 2012-04-24 | @ CLE | 17 | L 3-4 | 5-12 | 4 | 9,137 | Jonathan Sanchez | Derek Lowe | Derek Lowe | Jonathan Sanchez | Chris Perez | 60 | 85 | -25 |
| 2012-04-25 | @ CLE | 18 | W 8-2 | 6-12 | 4 | 10,552 | Luke Hochevar | Ubaldo Jimenez | Luke Hochevar | Ubaldo Jimenez | | 68 | 87 | -19 |
| 2012-04-26 | @ CLE | 19 | W 4-2 | 7-12 | 4 | 9,229 | Luis Mendoza | Josh Tomlin | Luis Mendoza | Josh Tomlin | Jonathan Broxton | 72 | 89 | -17 |
| 2012-04-27 | @ MIN | 20 | W 7-6 | 8-12 | 4 | 33,315 | Everett Teaford | Carl Pavano | Jose Mijares | Brian Duensing | Jonathan Broxton | 79 | 95 | -16 |
| 2012-04-29 | @ MIN | 21 | L 4-7 | 8-13 | 4 | 34,201 | Bruce Chen | Jason Marquis | Jason Marquis | Bruce Chen | | 83 | 102 | -19 |
| 2012-05-01 | @ DET | 22 | L 3-9 | 8-14 | 4 | 30,159 | Luke Hochevar | Rick Porcello | Rick Porcello | Luke Hochevar | | 86 | 111 | -25 |
| 2012-05-02 | @ DET | 23 | W 3-2 | 9-14 | 4 | 33,187 | Jonathan Sanchez | Justin Verlander | Tim Collins | Joaquin Benoit | Jonathan Broxton | 89 | 113 | -24 |
| 2012-05-03 | vs NYA | 24 | W 4-3 | 10-14 | 4 | 19,590 | Danny Duffy | David Phelps | Danny Duffy | David Phelps | Jonathan Broxton | 93 | 116 | -23 |
| 2012-05-04 | vs NYA | 25 | L 2-6 | 10-15 | 4 | 24,153 | Bruce Chen | CC Sabathia | CC Sabathia | Bruce Chen | | 95 | 122 | -27 |
| 2012-05-05 | vs NYA | 26 | W 5-1 | 11-15 | 4 | 29,121 | Felipe Paulino | Hiroki Kuroda | Felipe Paulino | Hiroki Kuroda | | 100 | 123 | -23 |
| 2012-05-06 | vs NYA | 27 | W 4-10 | 12-15 | 4 | 20,434 | Luke Hochevar | Phil Hughes | Phil Hughes | Luke Hochevar | | 104 | 133 | -29 |
| 2012-05-07 | vs BOS | 28 | W 5-11 | 13-15 | 6 | 19,502 | Jonathan Sanchez | Felix Doubront | Felix Doubront | Jonathan Sanchez | Vicente Padilla | 109 | 144 | -35 |
| 2012-05-08 | vs BOS | 29 | W 6-4 | 14-15 | 4 | 20,524 | Danny Duffy | Daniel Bard | Jose Mijares | Daniel Bard | Jonathan Broxton | 115 | 148 | -33 |
| 2012-05-09 | vs BOS | 30 | W 4-3 | 15-15 | 4 | 18,339 | Bruce Chen | Jon Lester | Bruce Chen | Jon Lester | Jonathan Broxton | 119 | 151 | -32 |
| 2012-05-11 | @ CHA | 31 | L 0-5 | 15-16 | 4 | 19,129 | Felipe Paulino | Gavin Floyd | Gavin Floyd | Felipe Paulino | | 119 | 156 | -37 |
| 2012-05-12 | @ CHA | 32 | W 5-0 | 16-16 | 4 | 20,066 | Luke Hochevar | Chris Sale | Luke Hochevar | Chris Sale | | 124 | 156 | -32 |
| 2012-05-13 | @ CHA | 33 | W 9-1 | 17-16 | 2 | 22,636 | Danny Duffy | Philip Humber | Luis Mendoza | Matt Thornton | | 133 | 157 | -24 |
| 2012-05-14 | @ TEX | 34 | W 3-1 | 18-16 | 2 | 38,702 | Bruce Chen | Scott Feldman | Bruce Chen | Scott Feldman | Jonathan Broxton | 136 | 158 | -22 |
| 2012-05-15 | @ TEX | 35 | W 7-4 | 19-16 | 1 | 37,210 | Vin Mazzaro | Colby Lewis | Vin Mazzaro | Colby Lewis | | 143 | 162 | -19 |
| 2012-05-16 | vs BAL | 36 | L 3-4 | 19-17 | 3 | 17,949 | Felipe Paulino | Tommy Hunter | Kevin Gregg | Nathan Adcock | Jim Johnson | 146 | 166 | -20 |
| 2012-05-17 | vs BAL | 37 | L 3-5 | 19-18 | 4 | 31,076 | Luke Hochevar | Brian Matusz | Brian Matusz | Luke Hochevar | Jim Johnson | 149 | 171 | -22 |
| 2012-05-18 | vs ARI | 38 | L 4-6 | 19-19 | 4 | 33,694 | Luis Mendoza | Joe Saunders | Brad Ziegler | Kelvin Herrera | J.J. Putz | 153 | 177 | -24 |
| 2012-05-19 | vs ARI | 39 | W 7-3 | 20-19 | 4 | 27,469 | Bruce Chen | Ian Kennedy | Bruce Chen | Ian Kennedy | | 160 | 180 | -20 |
| 2012-05-20 | vs ARI | 40 | L 0-2 | 20-20 | 4 | 24,234 | Nathan Adcock | Wade Miley | Wade Miley | Nathan Adcock | J.J. Putz | 160 | 182 | -22 |
| 2012-05-21 | @ NYA | 41 | W 6-0 | 21-20 | 4 | 39,229 | Felipe Paulino | Hiroki Kuroda | Felipe Paulino | Hiroki Kuroda | | 166 | 182 | -16 |
| 2012-05-22 | @ NYA | 42 | L 2-3 | 21-21 | 4 | 37,674 | Luke Hochevar | Phil Hughes | Phil Hughes | Luke Hochevar | Rafael Soriano | 168 | 185 | -17 |
| 2012-05-23 | @ NYA | 43 | L 3-8 | 21-22 | 4 | 40,407 | Will Smith | Andy Pettitte | Andy Pettitte | Will Smith | | 171 | 193 | -22 |
| 2012-05-25 | @ BAL | 44 | L 2-8 | 21-23 | 4 | 28,954 | Bruce Chen | Jason Hammel | Jason Hammel | Bruce Chen | | 173 | 201 | -28 |
| 2012-05-26 | @ BAL | 45 | W 4-3 | 22-23 | 4 | 26,714 | Felipe Paulino | Wei-Yin Chen | Greg Holland | Pedro Strop | Jonathan Broxton | 177 | 204 | -27 |
| 2012-05-27 | @ BAL | 46 | W 4-2 | 23-23 | 4 | 33,919 | Luke Hochevar | Brian Matusz | Tim Collins | Brian Matusz | Jonathan Broxton | 181 | 206 | -25 |
| 2012-05-28 | @ CLE | 47 | L 5-8 | 23-24 | 4 | 25,377 | Nathan Adcock | Josh Tomlin | Josh Tomlin | Nathan Adcock | Chris Perez | 186 | 214 | -28 |
| 2012-05-29 | @ CLE | 48 | W 8-2 | 24-24 | 3 | 14,253 | Will Smith | Justin Masterson | Will Smith | Justin Masterson | | 194 | 216 | -22 |
| 2012-05-30 | @ CLE | 49 | W 6-3 | 25-24 | 3 | 17,112 | Bruce Chen | Jeanmar Gomez | Bruce Chen | Jeanmar Gomez | Jonathan Broxton | 200 | 219 | -19 |
| 2012-06-01 | vs OAK | 50 | W 2-0 | 26-24 | 3 | 29,527 | Felipe Paulino | Bartolo Colon | Felipe Paulino | Bartolo Colon | Jonathan Broxton | 202 | 219 | -17 |
| 2012-06-02 | vs OAK | 51 | L 3-9 | 26-25 | 3 | 26,276 | Luke Hochevar | Brandon McCarthy | Brandon McCarthy | Luke Hochevar | | 205 | 228 | -23 |
| 2012-06-03 | vs OAK | 52 | W 2-0 | 27-25 | 3 | 21,111 | Vin Mazzaro | Tom Milone | Vin Mazzaro | Tom Milone | Jonathan Broxton | 207 | 228 | -21 |
| 2012-06-04 | vs MIN | 53 | W 7-10 | 28-25 | 3 | 16,531 | Will Smith | Cole De Vries | Cole De Vries | Will Smith | Matt Capps | 214 | 238 | -24 |
| 2012-06-05 | vs MIN | 54 | W 1-0 | 29-25 | 3 | 23,934 | Bruce Chen | Francisco Liriano | Bruce Chen | Francisco Liriano | Jonathan Broxton | 215 | 238 | -23 |
| 2012-06-06 | vs MIN | 55 | L 2-4 | 29-26 | 3 | 18,386 | Felipe Paulino | Nick Blackburn | Nick Blackburn | Luis Mendoza | Matt Capps | 217 | 242 | -25 |
| 2012-06-08 | @ PIT | 56 | L 2-4 | 29-27 | 3 | 36,069 | Luke Hochevar | Erik Bedard | Erik Bedard | Luke Hochevar | Joel Hanrahan | 219 | 246 | -27 |
| 2012-06-09 | @ PIT | 57 | L 3-5 | 29-28 | 3 | 39,312 | Vin Mazzaro | James McDonald | Jared Hughes | Vin Mazzaro | Joel Hanrahan | 222 | 251 | -29 |
| 2012-06-10 | @ PIT | 58 | L 2-3 | 29-29 | 3 | 25,752 | Bruce Chen | A.J. Burnett | A.J. Burnett | Bruce Chen | Jason Grilli | 224 | 254 | -30 |
| 2012-06-12 | vs MIL | 59 | W 2-1 | 30-29 | 3 | 24,258 | Luis Mendoza | Zack Greinke | Greg Holland | Francisco Rodriguez | Jonathan Broxton | 226 | 255 | -29 |
| 2012-06-13 | vs MIL | 60 | W 4-3 | 31-29 | 3 | 17,885 | Jonathan Sanchez | Randy Wolf | Tim Collins | Kameron Loe | | 230 | 258 | -28 |
| 2012-06-14 | vs MIL | 61 | W 4-3 | 32-29 | 3 | 21,869 | Luke Hochevar | Shaun Marcum | Tim Collins | John Axford | | 234 | 261 | -27 |
| 2012-06-15 | @ SLN | 62 | W 3-2 | 33-29 | 3 | 42,001 | Vin Mazzaro | Kyle Lohse | Vin Mazzaro | Kyle Lohse | Jonathan Broxton | 237 | 263 | -26 |
| 2012-06-16 | @ SLN | 63 | W 7-10 | 34-29 | 3 | 42,018 | Bruce Chen | Joe Kelly | Mitchell Boggs | Tim Collins | Jason Motte | 244 | 273 | -29 |
| 2012-06-17 | @ SLN | 64 | W 5-3 | 35-29 | 2 | 41,680 | Luis Mendoza | Adam Wainwright | Jonathan Broxton | Eduardo Sanchez | | 249 | 276 | -27 |
| 2012-06-18 | @ HOU | 65 | L 7-9 | 35-30 | 2 | 15,436 | Jonathan Sanchez | J.A. Happ | J.A. Happ | Jonathan Sanchez | Xavier Cedeno | 256 | 285 | -29 |
| 2012-06-19 | @ HOU | 66 | W 2-0 | 36-30 | 2 | 18,098 | Luke Hochevar | Wandy Rodriguez | Luke Hochevar | Wandy Rodriguez | Jonathan Broxton | 258 | 285 | -27 |
| 2012-06-20 | @ HOU | 67 | W 2-1 | 37-30 | 2 | 30,687 | Bruce Chen | Jordan Lyles | Bruce Chen | Jordan Lyles | Jonathan Broxton | 260 | 286 | -26 |
| 2012-06-22 | vs SLN | 68 | W 4-11 | 38-30 | 1 | 37,902 | Vin Mazzaro | Joe Kelly | Joe Kelly | Vin Mazzaro | | 264 | 297 | -33 |
| 2012-06-23 | vs SLN | 69 | L 2-8 | 38-31 | 2 | 37,240 | Luis Mendoza | Adam Wainwright | Adam Wainwright | Luis Mendoza | | 266 | 305 | -39 |
| 2012-06-24 | vs SLN | 70 | W 8-11 | 39-31 | 2 | 29,063 | Jonathan Sanchez | Lance Lynn | Victor Marte | Tim Collins | | 274 | 316 | -42 |
| 2012-06-25 | vs TBA | 71 | W 8-0 | 40-31 | 1 | 20,200 | Luke Hochevar | Alex Cobb | Luke Hochevar | Alex Cobb | | 282 | 316 | -34 |
| 2012-06-26 | vs TBA | 72 | W 8-2 | 41-31 | 1 | 25,982 | Bruce Chen | Chris Archer | Bruce Chen | Chris Archer | | 290 | 318 | -28 |
| 2012-06-27 | vs TBA | 73 | W 5-4 | 42-31 | 1 | 19,228 | Everett Teaford | Matt Moore | Aaron Crow | Burke Badenhop | Jonathan Broxton | 295 | 322 | -27 |
| 2012-06-29 | @ MIN | 74 | W 4-3 | 43-31 | 1 | 33,359 | Luis Mendoza | Brian Duensing | Luis Mendoza | Brian Duensing | Jonathan Broxton | 299 | 325 | -26 |
| 2012-06-30 | @ MIN | 75 | L 2-7 | 43-33 | 2 | 37,694 | Jonathan Sanchez | Scott Diamond | Scott Diamond | Jonathan Sanchez | | 301 | 332 | -31 |
| 2012-06-30 | @ MIN | 76 | L 1-5 | 43-33 | 2 | 37,629 | Luke Hochevar | Cole De Vries | Cole De Vries | Luke Hochevar | | 302 | 337 | -35 |
| 2012-07-01 | @ MIN | 77 | W 8-10 | 44-33 | 1 | 37,819 | Bruce Chen | Francisco Liriano | Jeff Gray | Bruce Chen | | 310 | 347 | -37 |
| 2012-07-02 | @ TOR | 78 | L 11-3 | 44-34 | 1 | 17,127 | Everett Teaford | Ricky Romero | Everett Teaford | Ricky Romero | | 321 | 350 | -29 |
| 2012-07-03 | @ TOR | 79 | L 3-6 | 44-35 | 1 | 15,516 | Vin Mazzaro | Brett Cecil | Brett Cecil | Vin Mazzaro | Casey Janssen | 324 | 356 | -32 |
| 2012-07-04 | @ TOR | 80 | L 1-4 | 44-36 | 1 | 17,831 | Luis Mendoza | Carlos Villanueva | Carlos Villanueva | Luis Mendoza | Casey Janssen | 325 | 360 | -35 |
| 2012-07-05 | @ TOR | 81 | W 9-6 | 45-36 | 1 | 20,598 | Luke Hochevar | Henderson Alvarez | Luke Hochevar | Henderson Alvarez | Jonathan Broxton | 334 | 366 | -32 |
| 2012-07-06 | @ DET | 82 | L 2-4 | 45-37 | 2 | 39,144 | Jonathan Sanchez | Drew Smyly | Drew Smyly | Jonathan Sanchez | Jose Valverde | 336 | 370 | -34 |
| 2012-07-07 | @ DET | 83 | L 7-8 | 45-38 | 2 | 39,392 | Bruce Chen | Doug Fister | Doug Fister | Bruce Chen | | 343 | 378 | -35 |
| 2012-07-08 | @ DET | 84 | L 1-7 | 45-39 | 3 | 36,693 | Everett Teaford | Max Scherzer | Max Scherzer | Everett Teaford | | 344 | 385 | -41 |
| 2012-07-13 | vs CHA | 85 | L 8-9 | 45-40 | 3 | 32,744 | Bruce Chen | Jose Quintana | Dylan Axelrod | Everett Teaford | | 352 | 394 | -42 |
| 2012-07-14 | vs CHA | 86 | W 6-3 | 46-40 | 3 | 24,998 | Luke Hochevar | Jake Peavy | Greg Holland | Jake Peavy | Jonathan Broxton | 358 | 397 | -39 |
| 2012-07-15 | vs CHA | 87 | L 1-2 | 46-41 | 3 | 25,714 | Luis Mendoza | Chris Sale | Chris Sale | Luis Mendoza | Addison Reed | 359 | 399 | -40 |
| 2012-07-16 | vs SEA | 88 | L 4-9 | 46-42 | 4 | 16,697 | Jonathan Sanchez | Jason Vargas | Jason Vargas | Jonathan Sanchez | | 363 | 408 | -45 |
| 2012-07-17 | vs SEA | 89 | L 6-9 | 46-43 | 4 | 15,769 | Ryan Verdugo | Blake Beavan | Blake Beavan | Ryan Verdugo | Tom Wilhelmsen | 369 | 417 | -48 |
| 2012-07-18 | vs SEA | 90 | W 8-7 | 47-43 | 3 | 17,312 | Bruce Chen | Kevin Millwood | Greg Holland | Josh Kinney | | 377 | 424 | -47 |
| 2012-07-19 | vs SEA | 91 | L 1-6 | 47-44 | 3 | 16,706 | Will Smith | Felix Hernandez | Felix Hernandez | Will Smith | | 378 | 430 | -52 |
| 2012-07-20 | vs MIN | 92 | L 1-2 | 47-45 | 4 | 25,719 | Luke Hochevar | Nick Blackburn | Casey Fien | Jonathan Broxton | Glen Perkins | 379 | 432 | -53 |
| 2012-07-21 | vs MIN | 93 | W 7-3 | 48-45 | 3 | 26,747 | Luis Mendoza | Scott Diamond | Luis Mendoza | Scott Diamond | Aaron Crow | 386 | 435 | -49 |
| 2012-07-22 | vs MIN | 94 | L 5-7 | 48-46 | 3 | 23,252 | Jeremy Guthrie | Samuel Deduno | Samuel Deduno | Jeremy Guthrie | | 391 | 442 | -51 |
| 2012-07-23 | @ ANA | 95 | L 3-6 | 48-47 | 4 | 35,047 | Bruce Chen | C.J. Wilson | Kevin Jepsen | Greg Holland | Scott Downs | 394 | 448 | -54 |
| 2012-07-24 | @ ANA | 96 | W 4-1 | 49-47 | 4 | 35,051 | Will Smith | Garrett Richards | Will Smith | Garrett Richards | Jonathan Broxton | 398 | 449 | -51 |
| 2012-07-25 | @ ANA | 97 | W 6-11 | 50-47 | 3 | 39,107 | Luke Hochevar | Jered Weaver | Jered Weaver | Luke Hochevar | | 404 | 460 | -56 |
| 2012-07-26 | @ SEA | 98 | L 1-4 | 50-48 | 4 | 15,014 | Luis Mendoza | Jason Vargas | Jason Vargas | Luis Mendoza | Tom Wilhelmsen | 405 | 464 | -59 |
| 2012-07-27 | @ SEA | 99 | L 1-6 | 50-49 | 4 | 14,953 | Jeremy Guthrie | Blake Beavan | Blake Beavan | Jeremy Guthrie | | 406 | 470 | -64 |
| 2012-07-28 | @ SEA | 100 | L 3-4 | 50-50 | 4 | 32,111 | Bruce Chen | Kevin Millwood | Kevin Millwood | Bruce Chen | Tom Wilhelmsen | 409 | 474 | -65 |
| 2012-07-29 | @ SEA | 101 | L 6-7 | 50-51 | 4 | 19,402 | Will Smith | Felix Hernandez | Oliver Perez | Jose Mijares | Tom Wilhelmsen | 415 | 481 | -66 |
| 2012-07-31 | vs CLE | 102 | W 8-3 | 51-51 | 4 | 18,569 | Luke Hochevar | Derek Lowe | Luke Hochevar | Derek Lowe | | 423 | 484 | -61 |
| 2012-08-01 | vs CLE | 103 | W 5-2 | 52-51 | 3 | 17,033 | Luis Mendoza | Zach McAllister | Luis Mendoza | Zach McAllister | Greg Holland | 428 | 486 | -58 |
| 2012-08-02 | vs CLE | 104 | W 7-6 | 53-51 | 3 | 15,135 | Bruce Chen | Corey Kluber | Aaron Crow | Esmil Rogers | | 435 | 492 | -57 |
| 2012-08-03 | vs TEX | 105 | L 3-5 | 53-52 | 3 | 26,889 | Jeremy Guthrie | Matt Harrison | Matt Harrison | Jeremy Guthrie | Alexi Ogando | 438 | 497 | -59 |
| 2012-08-04 | vs TEX | 106 | L 2-4 | 53-53 | 3 | 28,724 | Will Smith | Scott Feldman | Scott Feldman | Will Smith | Alexi Ogando | 440 | 501 | -61 |
| 2012-08-05 | vs TEX | 107 | W 7-6 | 54-53 | 3 | 22,007 | Luke Hochevar | Derek Holland | Greg Holland | Michael Kirkman | | 447 | 507 | -60 |
| 2012-08-06 | @ CHA | 108 | L 2-4 | 54-54 | 4 | 30,097 | Luis Mendoza | Chris Sale | Chris Sale | Luis Mendoza | Addison Reed | 449 | 511 | -62 |
| 2012-08-07 | @ CHA | 109 | W 5-2 | 55-54 | 3 | 27,194 | Bruce Chen | Jake Peavy | Bruce Chen | Jake Peavy | Greg Holland | 454 | 513 | -59 |
| 2012-08-08 | @ CHA | 110 | W 2-1 | 56-54 | 3 | 25,151 | Jeremy Guthrie | Jose Quintana | Jeremy Guthrie | Jose Quintana | Greg Holland | 456 | 514 | -58 |
| 2012-08-09 | @ BAL | 111 | W 8-2 | 57-54 | 3 | 21,226 | Will Smith | Wei-Yin Chen | Will Smith | Wei-Yin Chen | | 464 | 516 | -52 |
| 2012-08-10 | @ BAL | 112 | L 1-7 | 57-55 | 3 | 17,277 | Luke Hochevar | Miguel Gonzalez | Miguel Gonzalez | Luke Hochevar | | 465 | 523 | -58 |
| 2012-08-11 | @ BAL | 113 | W 7-3 | 58-55 | 3 | 40,456 | Luis Mendoza | Chris Tillman | Luis Mendoza | Chris Tillman | | 472 | 526 | -54 |
| 2012-08-12 | @ BAL | 114 | L 3-5 | 58-56 | 3 | 20,935 | Bruce Chen | Tommy Hunter | Luis Ayala | Bruce Chen | Jim Johnson | 475 | 531 | -56 |
| 2012-08-14 | vs OAK | 115 | W 5-0 | 59-56 | 3 | 16,107 | Jeremy Guthrie | Jarrod Parker | Jeremy Guthrie | Jarrod Parker | | 480 | 531 | -51 |
| 2012-08-15 | vs OAK | 116 | W 3-2 | 60-56 | 3 | 15,591 | Will Smith | Brandon McCarthy | Will Smith | Brandon McCarthy | Greg Holland | 483 | 533 | -50 |
| 2012-08-16 | vs OAK | 117 | L 0-3 | 60-57 | 3 | 14,345 | Luke Hochevar | Dan Straily | Dan Straily | Luke Hochevar | Grant Balfour | 483 | 536 | -53 |
| 2012-08-17 | vs CHA | 118 | W 4-2 | 61-57 | 3 | 22,169 | Luis Mendoza | Chris Sale | Luis Mendoza | Chris Sale | Greg Holland | 487 | 538 | -51 |
| 2012-08-18 | vs CHA | 119 | W 9-4 | 62-57 | 3 | 23,858 | Bruce Chen | Jake Peavy | Bruce Chen | Jake Peavy | | 496 | 542 | -46 |
| 2012-08-19 | vs CHA | 120 | W 5-2 | 63-57 | 3 | 22,401 | Jeremy Guthrie | Jose Quintana | Greg Holland | Jesse Crain | | 501 | 544 | -43 |
| 2012-08-20 | @ TBA | 121 | L 1-5 | 63-58 | 3 | 9,913 | Will Smith | Jeremy Hellickson | Jeremy Hellickson | Will Smith | | 502 | 549 | -47 |
| 2012-08-21 | @ TBA | 122 | W 1-0 | 64-58 | 3 | 10,877 | Luke Hochevar | David Price | Kelvin Herrera | Joel Peralta | Greg Holland | 503 | 549 | -46 |
| 2012-08-22 | @ TBA | 123 | L 3-5 | 64-59 | 3 | 11,892 | Luis Mendoza | James Shields | James Shields | Luis Mendoza | Fernando Rodney | 506 | 554 | -48 |
| 2012-08-24 | @ BOS | 124 | L 3-4 | 64-60 | 3 | 37,228 | Bruce Chen | Jon Lester | Jon Lester | Kelvin Herrera | Andrew Bailey | 509 | 558 | -49 |
| 2012-08-25 | @ BOS | 125 | L 10-9 | 64-61 | 3 | 37,103 | Jeremy Guthrie | Aaron Cook | Francisley Bueno | Junichi Tazawa | Greg Holland | 519 | 567 | -48 |
| 2012-08-26 | @ BOS | 126 | L 6-8 | 64-62 | 3 | 37,188 | Will Smith | Felix Doubront | Pedro Beato | Will Smith | Mark Melancon | 525 | 575 | -50 |
| 2012-08-27 | @ BOS | 127 | L 1-5 | 64-63 | 3 | 37,506 | Luke Hochevar | Daisuke Matsuzaka | Daisuke Matsuzaka | Luke Hochevar | | 526 | 580 | -54 |
| 2012-08-28 | vs DET | 128 | W 9-8 | 65-63 | 3 | 13,601 | Luis Mendoza | Justin Verlander | Aaron Crow | Brayan Villarreal | Greg Holland | 535 | 588 | -53 |
| 2012-08-29 | vs DET | 129 | W 1-0 | 66-63 | 3 | 13,024 | Bruce Chen | Anibal Sanchez | Bruce Chen | Anibal Sanchez | Greg Holland | 536 | 588 | -52 |
| 2012-08-30 | vs DET | 130 | W 2-1 | 67-63 | 3 | 12,997 | Jeremy Guthrie | Rick Porcello | Jeremy Guthrie | Rick Porcello | Kelvin Herrera | 538 | 589 | -51 |
| 2012-09-01 | vs MIN | 131 | L 1-3 | 67-65 | 4 | 0 | Will Smith | Cole De Vries | Cole De Vries | Will Smith | Glen Perkins | 539 | 592 | -53 |
| 2012-09-01 | vs MIN | 132 | L 7-8 | 67-65 | 4 | 23,189 | Luke Hochevar | Liam Hendriks | Anthony Swarzak | Luke Hochevar | Glen Perkins | 546 | 600 | -54 |
| 2012-09-02 | vs MIN | 133 | W 6-4 | 68-65 | 3 | 23,641 | Luis Mendoza | Esmerling Vasquez | Tim Collins | Esmerling Vasquez | Greg Holland | 552 | 604 | -52 |
| 2012-09-03 | vs TEX | 134 | L 4-8 | 68-66 | 3 | 22,207 | Bruce Chen | Yu Darvish | Yu Darvish | Bruce Chen | | 556 | 612 | -56 |
| 2012-09-04 | vs TEX | 135 | W 6-3 | 69-66 | 3 | 12,462 | Jeremy Guthrie | Matt Harrison | Jeremy Guthrie | Matt Harrison | Greg Holland | 562 | 615 | -53 |
| 2012-09-05 | vs TEX | 136 | L 6-7 | 69-67 | 3 | 13,354 | Everett Teaford | Ryan Dempster | Ryan Dempster | Everett Teaford | Joe Nathan | 568 | 622 | -54 |
| 2012-09-06 | vs TEX | 137 | L 4-5 | 69-68 | 3 | 15,332 | Luke Hochevar | Scott Feldman | Mike Adams | Greg Holland | Joe Nathan | 572 | 627 | -55 |
| 2012-09-07 | @ CHA | 138 | W 7-5 | 70-68 | 3 | 26,660 | Luis Mendoza | Francisco Liriano | Kelvin Herrera | Addison Reed | Greg Holland | 579 | 632 | -53 |
| 2012-09-08 | @ CHA | 139 | L 4-5 | 70-69 | 3 | 26,227 | Bruce Chen | Chris Sale | Chris Sale | Bruce Chen | Addison Reed | 583 | 637 | -54 |
| 2012-09-09 | @ CHA | 140 | W 2-1 | 71-69 | 3 | 19,356 | Jeremy Guthrie | Hector Santiago | Kelvin Herrera | Brett Myers | Greg Holland | 585 | 638 | -53 |
| 2012-09-11 | @ MIN | 141 | W 9-1 | 72-69 | 3 | 28,993 | Will Smith | Scott Diamond | Will Smith | Scott Diamond | | 594 | 639 | -45 |
| 2012-09-12 | @ MIN | 142 | L 10-5 | 72-70 | 3 | 28,139 | Luke Hochevar | P.J. Walters | Luke Hochevar | P.J. Walters | | 604 | 644 | -40 |
| 2012-09-13 | @ MIN | 143 | L 3-4 | 72-71 | 3 | 28,669 | Luis Mendoza | Liam Hendriks | Glen Perkins | Francisley Bueno | | 607 | 648 | -41 |
| 2012-09-14 | vs ANA | 144 | L 7-9 | 72-72 | 3 | 27,586 | Bruce Chen | C.J. Wilson | Jordan Walden | Tim Collins | Ernesto Frieri | 614 | 657 | -43 |
| 2012-09-15 | vs ANA | 145 | W 3-2 | 73-72 | 3 | 23,027 | Jeremy Guthrie | Zack Greinke | Kelvin Herrera | Ernesto Frieri | | 617 | 659 | -42 |
| 2012-09-16 | vs ANA | 146 | L 3-4 | 73-73 | 3 | 24,979 | Will Smith | Dan Haren | Dan Haren | Will Smith | Kevin Jepsen | 620 | 663 | -43 |
| 2012-09-18 | vs CHA | 147 | L 2-3 | 73-74 | 3 | 14,420 | Luke Hochevar | Gavin Floyd | Gavin Floyd | Luke Hochevar | Addison Reed | 622 | 666 | -44 |
| 2012-09-19 | vs CHA | 148 | W 3-0 | 74-74 | 3 | 15,120 | Bruce Chen | Chris Sale | Bruce Chen | Chris Sale | Greg Holland | 625 | 666 | -41 |
| 2012-09-20 | vs CHA | 149 | W 4-3 | 75-74 | 3 | 14,710 | Jeremy Guthrie | Francisco Liriano | Greg Holland | Jesse Crain | | 629 | 669 | -40 |
| 2012-09-21 | vs CLE | 150 | W 6-3 | 76-74 | 3 | 22,805 | Luis Mendoza | Justin Masterson | Luis Mendoza | Justin Masterson | Greg Holland | 635 | 672 | -37 |
| 2012-09-22 | vs CLE | 151 | W 5-3 | 77-74 | 3 | 24,304 | Will Smith | Ubaldo Jimenez | Will Smith | Ubaldo Jimenez | Kelvin Herrera | 640 | 675 | -35 |
| 2012-09-23 | vs CLE | 152 | W 4-15 | 78-74 | 4 | 22,960 | Jake Odorizzi | David Huff | David Huff | Jake Odorizzi | | 644 | 690 | -46 |
| 2012-09-24 | @ DET | 153 | L 2-6 | 78-75 | 3 | 31,521 | Luke Hochevar | Justin Verlander | Justin Verlander | Luke Hochevar | | 646 | 696 | -50 |
| 2012-09-25 | @ DET | 154 | L 0-2 | 78-76 | 3 | 29,048 | Bruce Chen | Anibal Sanchez | Anibal Sanchez | Bruce Chen | | 646 | 698 | -52 |
| 2012-09-26 | @ DET | 155 | L 4-5 | 78-77 | 3 | 32,360 | Jeremy Guthrie | Rick Porcello | Joaquin Benoit | Kelvin Herrera | Jose Valverde | 650 | 703 | -53 |
| 2012-09-27 | @ DET | 156 | L 4-5 | 78-78 | 3 | 33,019 | Luis Mendoza | Doug Fister | Joaquin Benoit | Tim Collins | | 654 | 708 | -54 |
| 2012-09-28 | @ CLE | 157 | L 5-8 | 78-79 | 3 | 14,850 | Will Smith | David Huff | David Huff | Will Smith | Chris Perez | 659 | 716 | -57 |
| 2012-09-29 | @ CLE | 158 | W 7-6 | 79-79 | 3 | 17,109 | Jake Odorizzi | Jeanmar Gomez | Vin Mazzaro | Scott Maine | Kelvin Herrera | 666 | 722 | -56 |
| 2012-09-30 | @ CLE | 159 | W 3-15 | 80-79 | 3 | 18,099 | Luke Hochevar | Zach McAllister | Zach McAllister | Luke Hochevar | | 669 | 737 | -68 |
| 2012-10-01 | vs DET | 160 | L 3-6 | 80-80 | 3 | 15,312 | Bruce Chen | Rick Porcello | Rick Porcello | Bruce Chen | Jose Valverde | 672 | 743 | -71 |
| 2012-10-02 | vs DET | 161 | W 4-2 | 81-80 | 3 | 14,283 | Jeremy Guthrie | Doug Fister | Jeremy Guthrie | Doug Fister | Greg Holland | 676 | 745 | -69 |
| 2012-10-03 | vs DET | 162 | L 0-1 | 81-81 | 3 | 30,383 | Luis Mendoza | Max Scherzer | Luis Marte | Luis Mendoza | Luke Putkonen | 676 | 746 | -70 |