| Central | W | L | Pct | GB |
| Detroit | 88 | 74 | .543 | -- |
| Chi White Sox | 85 | 77 | .525 | 3.0 |
| KC Royals | 72 | 90 | .444 | 16.0 |
| Cleveland | 68 | 94 | .420 | 20.0 |
| Minnesota | 66 | 96 | .407 | 22.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2012-04-05 | Justin Verlander | R | 29 | L 3-2 | vs BOS | 1 | 200 | - | 8.0 | 2 | 0 | 0 | 0 | 1 | 7 | 105 | 39 | 66 | 63% | 0-0 | 0.00 | 0.38 |
| 2012-04-07 | Doug Fister | R | 28 | L 10-0 | vs BOS | 1 | 70 | - | 3.2 | 3 | 0 | 0 | 0 | 1 | 3 | 50 | 22 | 28 | 56% | 0-0 | 0.00 | 1.00 |
| 2012-04-08 | Max Scherzer | R | 28 | L 13-12 | vs BOS | 1 | 102 | - | 2.2 | 8 | 7 | 7 | 0 | 2 | 3 | 77 | 29 | 48 | 62% | 0-0 | 21.00 | 3.33 |
| 2012-04-10 | Rick Porcello | R | 23 | L 5-2 | vs TBA | 1 | 90 | - | 7.0 | 7 | 2 | 2 | 0 | 1 | 4 | 89 | 31 | 58 | 65% | 0-0 | 2.57 | 1.14 |
| 2012-04-11 | Justin Verlander | R | 29 | W 2-4 | vs TBA | 2 | 201 | L | 8.1 | 4 | 4 | 4 | 0 | 2 | 7 | 103 | 34 | 69 | 67% | 0-1 | 2.25 | 0.56 |
| 2012-04-12 | Drew Smyly | L | 23 | L 7-2 | vs TBA | 1 | 1 | - | 4.0 | 4 | 1 | 1 | 1 | 3 | 4 | 90 | 41 | 49 | 54% | 0-0 | 2.25 | 1.75 |
| 2012-04-13 | Max Scherzer | R | 28 | L 2-5 | @ CHA | 2 | 103 | L | 6.0 | 5 | 3 | 3 | 1 | 1 | 11 | 100 | 35 | 65 | 65% | 0-1 | 10.00 | 1.78 |
| 2012-04-14 | Adam Wilk | L | 24 | L 1-5 | @ CHA | 1 | 1 | L | 5.0 | 3 | 2 | 2 | 2 | 1 | 4 | 62 | 22 | 40 | 65% | 0-1 | 3.60 | 0.80 |
| 2012-04-15 | Rick Porcello | R | 23 | W 5-2 | @ CHA | 2 | 91 | W | 7.2 | 5 | 1 | 1 | 1 | 0 | 4 | 104 | 32 | 72 | 69% | 1-0 | 1.80 | 0.87 |
| 2012-04-16 | Justin Verlander | R | 29 | W 3-2 | @ KCA | 3 | 202 | W | 9.0 | 7 | 2 | 2 | 0 | 2 | 9 | 135 | 49 | 86 | 64% | 1-1 | 2.16 | 0.72 |
| 2012-04-17 | Drew Smyly | L | 23 | W 3-1 | @ KCA | 2 | 2 | - | 6.0 | 7 | 1 | 0 | 0 | 1 | 4 | 101 | 35 | 66 | 65% | 0-0 | 0.90 | 1.50 |
| 2012-04-18 | Max Scherzer | R | 28 | W 4-3 | @ KCA | 3 | 104 | W | 6.0 | 7 | 3 | 3 | 1 | 1 | 3 | 97 | 32 | 65 | 67% | 1-1 | 7.80 | 1.60 |
| 2012-04-19 | Adam Wilk | L | 24 | W 3-10 | vs TEX | 2 | 2 | L | 4.0 | 10 | 3 | 2 | 1 | 1 | 2 | 68 | 23 | 45 | 66% | 0-2 | 4.00 | 1.67 |
| 2012-04-21 | Rick Porcello | R | 23 | W 4-10 | vs TEX | 3 | 92 | L | 1.0 | 10 | 9 | 8 | 1 | 1 | 1 | 50 | 13 | 37 | 74% | 1-1 | 6.19 | 1.50 |
| 2012-04-21 | Justin Verlander | R | 29 | L 3-2 | vs TEX | 4 | 203 | W | 6.0 | 4 | 1 | 0 | 0 | 3 | 8 | 115 | 38 | 77 | 67% | 2-1 | 1.74 | 0.81 |
| 2012-04-22 | Drew Smyly | L | 23 | W 2-3 | vs TEX | 3 | 3 | - | 6.0 | 5 | 1 | 1 | 1 | 2 | 7 | 98 | 35 | 63 | 64% | 0-0 | 1.13 | 1.38 |
| 2012-04-24 | Max Scherzer | R | 28 | W 4-7 | vs SEA | 4 | 105 | L | 5.0 | 10 | 5 | 5 | 0 | 2 | 6 | 98 | 38 | 60 | 61% | 1-2 | 8.10 | 1.80 |
| 2012-04-25 | Adam Wilk | L | 24 | W 1-9 | vs SEA | 3 | 3 | L | 2.0 | 8 | 6 | 6 | 1 | 1 | 1 | 60 | 24 | 36 | 60% | 0-3 | 8.18 | 2.18 |
| 2012-04-26 | Rick Porcello | R | 23 | W 4-5 | vs SEA | 4 | 93 | L | 6.2 | 7 | 5 | 5 | 2 | 2 | 3 | 105 | 43 | 62 | 59% | 1-2 | 6.55 | 1.50 |
| 2012-04-27 | Justin Verlander | R | 29 | L 6-7 | @ NYA | 5 | 204 | - | 6.0 | 7 | 5 | 4 | 2 | 0 | 4 | 100 | 37 | 63 | 63% | 2-1 | 2.43 | 0.86 |
| 2012-04-28 | Drew Smyly | L | 23 | W 7-5 | @ NYA | 4 | 4 | W | 6.0 | 2 | 1 | 1 | 1 | 2 | 7 | 92 | 36 | 56 | 61% | 1-0 | 1.23 | 1.18 |
| 2012-04-29 | Max Scherzer | R | 28 | L 2-6 | @ NYA | 5 | 106 | L | 4.2 | 7 | 3 | 3 | 1 | 7 | 4 | 119 | 57 | 62 | 52% | 1-3 | 7.88 | 2.08 |
| 2012-05-01 | Rick Porcello | R | 23 | L 9-3 | vs KCA | 5 | 94 | W | 8.0 | 7 | 3 | 3 | 0 | 0 | 3 | 98 | 28 | 70 | 71% | 2-2 | 5.70 | 1.33 |
| 2012-05-02 | Justin Verlander | R | 29 | W 2-3 | vs KCA | 6 | 205 | - | 8.0 | 6 | 2 | 2 | 0 | 1 | 7 | 120 | 42 | 78 | 65% | 2-1 | 2.40 | 0.87 |
| 2012-05-04 | Drew Smyly | L | 23 | L 5-4 | vs CHA | 5 | 5 | - | 6.0 | 7 | 2 | 2 | 0 | 0 | 7 | 98 | 37 | 61 | 62% | 1-0 | 1.61 | 1.18 |
| 2012-05-05 | Max Scherzer | R | 28 | W 2-3 | vs CHA | 6 | 107 | - | 7.0 | 4 | 1 | 1 | 1 | 0 | 9 | 97 | 29 | 68 | 70% | 1-3 | 6.39 | 1.74 |
| 2012-05-06 | Rick Porcello | R | 23 | L 3-1 | vs CHA | 6 | 95 | W | 6.1 | 4 | 1 | 1 | 1 | 2 | 5 | 102 | 33 | 69 | 68% | 3-2 | 4.86 | 1.24 |
| 2012-05-07 | Doug Fister | R | 28 | L 2-3 | @ SEA | 2 | 71 | - | 7.0 | 4 | 0 | 0 | 0 | 0 | 3 | 73 | 22 | 51 | 70% | 0-0 | 0.00 | 0.73 |
| 2012-05-08 | Justin Verlander | R | 29 | W 6-4 | @ SEA | 7 | 206 | W | 6.0 | 7 | 3 | 3 | 0 | 2 | 6 | 113 | 46 | 67 | 59% | 3-1 | 2.65 | 0.94 |
| 2012-05-09 | Drew Smyly | L | 23 | L 1-2 | @ SEA | 6 | 6 | - | 6.0 | 2 | 1 | 1 | 0 | 2 | 5 | 95 | 36 | 59 | 62% | 1-0 | 1.59 | 1.09 |
| 2012-05-10 | Max Scherzer | R | 28 | W 10-6 | @ OAK | 7 | 108 | W | 6.1 | 5 | 2 | 2 | 1 | 2 | 9 | 106 | 41 | 65 | 61% | 2-3 | 5.68 | 1.61 |
| 2012-05-11 | Rick Porcello | R | 23 | L 4-11 | @ OAK | 7 | 96 | L | 5.0 | 9 | 4 | 4 | 1 | 3 | 4 | 102 | 40 | 62 | 61% | 3-3 | 5.14 | 1.38 |
| 2012-05-12 | Doug Fister | R | 28 | L 1-3 | @ OAK | 3 | 72 | L | 6.0 | 5 | 1 | 1 | 0 | 2 | 8 | 105 | 36 | 69 | 66% | 0-1 | 0.53 | 0.88 |
| 2012-05-13 | Justin Verlander | R | 29 | W 3-1 | @ OAK | 8 | 207 | W | 7.0 | 2 | 1 | 1 | 1 | 1 | 8 | 104 | 36 | 68 | 65% | 4-1 | 2.48 | 0.88 |
| 2012-05-14 | Drew Smyly | L | 23 | L 5-7 | @ CHA | 7 | 7 | - | 5.0 | 5 | 4 | 4 | 2 | 1 | 4 | 67 | 24 | 43 | 64% | 1-0 | 2.31 | 1.10 |
| 2012-05-15 | Max Scherzer | R | 28 | W 10-8 | @ CHA | 8 | 109 | - | 4.0 | 8 | 6 | 5 | 1 | 3 | 3 | 100 | 38 | 62 | 62% | 2-3 | 6.21 | 1.71 |
| 2012-05-16 | Rick Porcello | R | 23 | W 7-11 | vs MIN | 8 | 97 | - | 4.0 | 6 | 6 | 2 | 1 | 0 | 3 | 99 | 35 | 64 | 65% | 3-3 | 5.09 | 1.39 |
| 2012-05-17 | Doug Fister | R | 28 | W 3-4 | vs MIN | 4 | 73 | L | 6.0 | 9 | 4 | 3 | 2 | 2 | 5 | 107 | 40 | 67 | 63% | 0-2 | 1.57 | 1.13 |
| 2012-05-18 | Justin Verlander | R | 29 | L 6-0 | vs PIT | 9 | 208 | W | 9.0 | 1 | 0 | 0 | 0 | 2 | 12 | 109 | 33 | 76 | 70% | 5-1 | 2.15 | 0.81 |
| 2012-05-19 | Drew Smyly | L | 23 | W 3-4 | vs PIT | 8 | 8 | L | 4.2 | 7 | 4 | 4 | 2 | 2 | 6 | 91 | 30 | 61 | 67% | 1-1 | 2.86 | 1.18 |
| 2012-05-20 | Max Scherzer | R | 28 | L 4-3 | vs PIT | 9 | 110 | W | 7.0 | 4 | 2 | 2 | 2 | 1 | 15 | 110 | 35 | 75 | 68% | 3-3 | 5.69 | 1.57 |
| 2012-05-22 | Rick Porcello | R | 23 | L 3-5 | @ CLE | 9 | 98 | L | 5.1 | 8 | 5 | 4 | 0 | 3 | 6 | 108 | 42 | 66 | 61% | 3-4 | 5.29 | 1.47 |
| 2012-05-23 | Doug Fister | R | 28 | L 2-4 | @ CLE | 5 | 74 | - | 6.2 | 5 | 2 | 2 | 1 | 2 | 3 | 111 | 42 | 69 | 62% | 0-2 | 1.86 | 1.14 |
| 2012-05-24 | Justin Verlander | R | 29 | L 1-2 | @ CLE | 10 | 209 | L | 8.0 | 6 | 2 | 2 | 1 | 1 | 7 | 118 | 40 | 78 | 66% | 5-2 | 2.16 | 0.81 |
| 2012-05-25 | Drew Smyly | L | 23 | W 10-6 | @ MIN | 9 | 9 | W | 5.0 | 6 | 4 | 3 | 0 | 2 | 2 | 93 | 36 | 57 | 61% | 2-1 | 3.12 | 1.22 |
| 2012-05-26 | Max Scherzer | R | 28 | W 6-3 | @ MIN | 10 | 111 | W | 5.1 | 6 | 3 | 3 | 2 | 0 | 9 | 79 | 28 | 51 | 65% | 4-3 | 5.67 | 1.54 |
| 2012-05-27 | Rick Porcello | R | 23 | W 4-3 | @ MIN | 10 | 99 | - | 6.0 | 9 | 3 | 3 | 0 | 3 | 2 | 111 | 47 | 64 | 58% | 3-4 | 5.21 | 1.53 |
| 2012-05-28 | Doug Fister | R | 28 | L 4-7 | @ BOS | 6 | 75 | L | 5.0 | 11 | 6 | 6 | 1 | 1 | 2 | 89 | 31 | 58 | 65% | 0-3 | 3.18 | 1.32 |
| 2012-05-29 | Justin Verlander | R | 29 | L 3-6 | @ BOS | 11 | 210 | L | 6.0 | 10 | 5 | 5 | 0 | 1 | 7 | 105 | 30 | 75 | 71% | 5-3 | 2.56 | 0.89 |
| 2012-05-30 | Drew Smyly | L | 23 | L 4-6 | @ BOS | 10 | 10 | - | 6.0 | 8 | 4 | 4 | 2 | 0 | 4 | 85 | 27 | 58 | 68% | 2-1 | 3.44 | 1.24 |
| 2012-05-31 | Max Scherzer | R | 28 | W 7-3 | @ BOS | 11 | 112 | W | 6.0 | 7 | 3 | 3 | 1 | 2 | 6 | 120 | 43 | 77 | 64% | 5-3 | 5.55 | 1.53 |
| 2012-06-01 | Casey Crosby | L | 24 | W 4-9 | vs NYA | 1 | 1 | L | 3.1 | 4 | 6 | 6 | 1 | 4 | 3 | 75 | 35 | 40 | 53% | 0-1 | 18.00 | 2.67 |
| 2012-06-02 | Rick Porcello | R | 23 | L 4-3 | vs NYA | 11 | 100 | - | 6.0 | 6 | 1 | 1 | 0 | 1 | 3 | 98 | 32 | 66 | 67% | 3-4 | 4.86 | 1.49 |
| 2012-06-03 | Justin Verlander | R | 29 | W 1-5 | vs NYA | 12 | 211 | L | 6.1 | 9 | 4 | 3 | 2 | 4 | 4 | 113 | 48 | 65 | 58% | 5-4 | 2.66 | 0.97 |
| 2012-06-05 | Drew Smyly | L | 23 | W 2-4 | vs CLE | 11 | 11 | L | 6.0 | 6 | 4 | 4 | 0 | 2 | 5 | 91 | 28 | 63 | 69% | 2-2 | 3.69 | 1.25 |
| 2012-06-06 | Max Scherzer | R | 28 | W 6-9 | vs CLE | 12 | 113 | L | 4.1 | 7 | 8 | 5 | 2 | 3 | 2 | 92 | 35 | 57 | 62% | 5-4 | 5.91 | 1.59 |
| 2012-06-07 | Casey Crosby | L | 24 | L 7-5 | vs CLE | 2 | 2 | W | 5.1 | 5 | 3 | 3 | 0 | 3 | 2 | 90 | 37 | 53 | 59% | 1-1 | 9.00 | 1.78 |
| 2012-06-08 | Rick Porcello | R | 23 | L 5-6 | @ CIN | 12 | 101 | - | 5.0 | 9 | 4 | 4 | 1 | 2 | 1 | 83 | 34 | 49 | 59% | 3-4 | 5.03 | 1.54 |
| 2012-06-09 | Justin Verlander | R | 29 | W 3-2 | @ CIN | 13 | 212 | - | 6.0 | 6 | 2 | 2 | 0 | 3 | 9 | 125 | 42 | 83 | 66% | 5-4 | 2.68 | 1.00 |
| 2012-06-10 | Drew Smyly | L | 23 | W 7-6 | @ CIN | 12 | 12 | - | 3.0 | 4 | 3 | 3 | 1 | 1 | 3 | 57 | 21 | 36 | 63% | 2-2 | 3.94 | 1.27 |
| 2012-06-12 | Max Scherzer | R | 28 | L 3-4 | @ CHN | 13 | 114 | - | 6.0 | 5 | 3 | 3 | 0 | 5 | 8 | 126 | 58 | 68 | 54% | 5-4 | 5.79 | 1.60 |
| 2012-06-13 | Rick Porcello | R | 23 | W 8-4 | @ CHN | 13 | 102 | W | 5.0 | 9 | 4 | 4 | 0 | 1 | 5 | 76 | 30 | 46 | 61% | 4-4 | 5.18 | 1.58 |
| 2012-06-14 | Justin Verlander | R | 29 | W 5-3 | @ CHN | 14 | 213 | W | 8.0 | 5 | 2 | 2 | 0 | 0 | 8 | 101 | 30 | 71 | 70% | 6-4 | 2.65 | 0.97 |
| 2012-06-15 | Casey Crosby | L | 24 | W 4-12 | vs COL | 3 | 3 | - | 3.2 | 6 | 4 | 4 | 1 | 4 | 4 | 75 | 28 | 47 | 63% | 1-1 | 9.75 | 2.17 |
| 2012-06-16 | Doug Fister | R | 28 | L 4-1 | vs COL | 7 | 76 | W | 6.0 | 3 | 0 | 0 | 0 | 1 | 6 | 82 | 28 | 54 | 66% | 1-3 | 2.70 | 1.23 |
| 2012-06-17 | Max Scherzer | R | 28 | L 5-0 | vs COL | 14 | 115 | W | 8.0 | 7 | 0 | 0 | 0 | 0 | 12 | 121 | 33 | 88 | 73% | 6-4 | 5.19 | 1.53 |
| 2012-06-19 | Justin Verlander | R | 29 | L 6-3 | vs SLN | 15 | 214 | W | 7.0 | 5 | 3 | 1 | 0 | 4 | 3 | 108 | 38 | 70 | 65% | 7-4 | 2.56 | 0.99 |
| 2012-06-20 | Rick Porcello | R | 23 | W 1-3 | vs SLN | 14 | 103 | L | 7.0 | 10 | 2 | 2 | 0 | 1 | 2 | 86 | 31 | 55 | 64% | 4-5 | 4.95 | 1.58 |
| 2012-06-21 | Jacob Turner | R | 21 | L 2-1 | vs SLN | 1 | 4 | - | 5.0 | 4 | 1 | 1 | 0 | 5 | 3 | 93 | 41 | 52 | 56% | 0-0 | 1.80 | 1.80 |
| 2012-06-22 | Doug Fister | R | 28 | L 1-4 | @ PIT | 8 | 77 | L | 6.0 | 8 | 4 | 2 | 0 | 1 | 7 | 97 | 33 | 64 | 66% | 1-4 | 2.74 | 1.26 |
| 2012-06-23 | Max Scherzer | R | 28 | L 1-4 | @ PIT | 15 | 116 | L | 6.0 | 3 | 3 | 3 | 1 | 1 | 7 | 104 | 35 | 69 | 66% | 6-5 | 5.14 | 1.46 |
| 2012-06-24 | Justin Verlander | R | 29 | W 3-2 | @ PIT | 16 | 215 | W | 9.0 | 5 | 2 | 2 | 1 | 1 | 7 | 117 | 39 | 78 | 67% | 8-4 | 2.52 | 0.97 |
| 2012-06-25 | Rick Porcello | R | 23 | W 8-2 | @ TEX | 15 | 104 | W | 6.0 | 6 | 1 | 1 | 0 | 3 | 7 | 95 | 38 | 57 | 60% | 5-5 | 4.71 | 1.57 |
| 2012-06-26 | Drew Smyly | L | 23 | L 5-7 | @ TEX | 13 | 13 | L | 4.2 | 8 | 6 | 6 | 1 | 2 | 3 | 104 | 42 | 62 | 60% | 2-3 | 4.50 | 1.34 |
| 2012-06-27 | Doug Fister | R | 28 | L 9-13 | @ TEX | 9 | 78 | L | 4.1 | 9 | 9 | 8 | 3 | 1 | 5 | 99 | 32 | 67 | 68% | 1-5 | 3.88 | 1.33 |
| 2012-06-28 | Max Scherzer | R | 28 | W 5-2 | @ TBA | 16 | 117 | W | 6.0 | 4 | 2 | 2 | 0 | 2 | 7 | 109 | 47 | 62 | 57% | 7-5 | 5.00 | 1.43 |
| 2012-06-29 | Justin Verlander | R | 29 | L 2-4 | @ TBA | 17 | 216 | L | 6.0 | 6 | 4 | 4 | 3 | 1 | 8 | 126 | 49 | 77 | 61% | 8-5 | 2.69 | 0.98 |
| 2012-06-30 | Rick Porcello | R | 24 | W 6-2 | @ TBA | 16 | 105 | W | 7.0 | 4 | 0 | 0 | 0 | 0 | 4 | 87 | 30 | 57 | 66% | 6-5 | 4.35 | 1.49 |
| 2012-07-01 | Drew Smyly | L | 23 | W 5-3 | @ TBA | 14 | 14 | W | 5.0 | 3 | 3 | 3 | 0 | 1 | 4 | 95 | 38 | 57 | 60% | 3-3 | 4.56 | 1.30 |
| 2012-07-02 | Doug Fister | R | 28 | W 4-6 | vs MIN | 10 | 79 | L | 4.0 | 8 | 6 | 6 | 0 | 1 | 4 | 84 | 27 | 57 | 68% | 1-6 | 4.58 | 1.40 |
| 2012-07-03 | Duane Below | L | 27 | W 6-8 | vs MIN | 1 | 3 | - | 2.2 | 5 | 5 | 1 | 1 | 0 | 3 | 59 | 18 | 41 | 69% | 2-1 | 2.75 | 1.00 |
| 2012-07-04 | Justin Verlander | R | 29 | L 5-1 | vs MIN | 18 | 217 | W | 9.0 | 4 | 1 | 1 | 1 | 1 | 7 | 115 | 40 | 75 | 65% | 9-5 | 2.57 | 0.95 |
| 2012-07-05 | Rick Porcello | R | 24 | L 7-3 | vs MIN | 17 | 106 | - | 3.2 | 12 | 3 | 3 | 0 | 1 | 0 | 76 | 25 | 51 | 67% | 6-5 | 4.45 | 1.57 |
| 2012-07-06 | Drew Smyly | L | 23 | L 4-2 | vs KCA | 15 | 15 | W | 6.0 | 6 | 2 | 2 | 0 | 0 | 10 | 106 | 35 | 71 | 67% | 4-3 | 4.44 | 1.28 |
| 2012-07-07 | Doug Fister | R | 28 | L 8-7 | vs KCA | 11 | 80 | W | 6.0 | 8 | 4 | 4 | 1 | 3 | 2 | 95 | 34 | 61 | 64% | 2-6 | 4.72 | 1.44 |
| 2012-07-08 | Max Scherzer | R | 28 | L 7-1 | vs KCA | 17 | 118 | W | 7.0 | 5 | 1 | 1 | 1 | 1 | 7 | 108 | 33 | 75 | 69% | 8-5 | 4.73 | 1.39 |
| 2012-07-13 | Doug Fister | R | 28 | W 7-2 | @ BAL | 12 | 81 | W | 7.0 | 3 | 1 | 1 | 0 | 0 | 8 | 94 | 29 | 65 | 69% | 3-6 | 4.37 | 1.34 |
| 2012-07-14 | Max Scherzer | R | 28 | L 6-8 | @ BAL | 18 | 119 | - | 5.0 | 9 | 4 | 4 | 1 | 2 | 4 | 94 | 33 | 61 | 65% | 8-5 | 4.85 | 1.43 |
| 2012-07-15 | Justin Verlander | R | 29 | W 4-0 | @ BAL | 19 | 218 | W | 8.0 | 3 | 0 | 0 | 0 | 2 | 8 | 116 | 43 | 73 | 63% | 10-5 | 2.43 | 0.93 |
| 2012-07-16 | Rick Porcello | R | 24 | L 8-6 | vs ANA | 18 | 107 | - | 5.2 | 8 | 5 | 5 | 0 | 3 | 5 | 89 | 30 | 59 | 66% | 6-5 | 4.68 | 1.60 |
| 2012-07-17 | Jacob Turner | R | 21 | W 0-13 | vs ANA | 2 | 5 | L | 2.0 | 6 | 7 | 7 | 3 | 2 | 1 | 52 | 21 | 31 | 60% | 0-1 | 10.29 | 2.43 |
| 2012-07-18 | Doug Fister | R | 28 | L 7-2 | vs ANA | 13 | 82 | W | 8.0 | 2 | 1 | 1 | 1 | 2 | 10 | 107 | 42 | 65 | 61% | 4-6 | 4.03 | 1.25 |
| 2012-07-19 | Max Scherzer | R | 28 | L 5-1 | vs ANA | 19 | 120 | W | 7.0 | 3 | 1 | 1 | 1 | 4 | 9 | 108 | 39 | 69 | 64% | 9-5 | 4.62 | 1.40 |
| 2012-07-20 | Justin Verlander | R | 29 | L 4-2 | vs CHA | 20 | 219 | W | 8.0 | 4 | 2 | 2 | 1 | 2 | 6 | 120 | 42 | 78 | 65% | 11-5 | 2.42 | 0.92 |
| 2012-07-21 | Rick Porcello | R | 24 | L 7-1 | vs CHA | 19 | 108 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 4 | 94 | 30 | 64 | 68% | 7-5 | 4.42 | 1.53 |
| 2012-07-22 | Jacob Turner | R | 21 | L 6-4 | vs CHA | 3 | 6 | W | 5.1 | 7 | 3 | 3 | 1 | 0 | 3 | 80 | 24 | 56 | 70% | 1-1 | 8.25 | 2.00 |
| 2012-07-24 | Doug Fister | R | 28 | L 2-3 | @ CLE | 14 | 83 | L | 7.0 | 9 | 3 | 3 | 0 | 1 | 4 | 102 | 29 | 73 | 72% | 4-7 | 4.01 | 1.27 |
| 2012-07-25 | Max Scherzer | R | 28 | W 5-3 | @ CLE | 20 | 121 | W | 7.0 | 3 | 2 | 2 | 1 | 4 | 8 | 108 | 43 | 65 | 60% | 10-5 | 4.50 | 1.38 |
| 2012-07-26 | Justin Verlander | R | 29 | L 3-5 | @ CLE | 21 | 220 | L | 7.0 | 8 | 5 | 4 | 2 | 2 | 4 | 105 | 32 | 73 | 70% | 11-6 | 2.54 | 0.94 |
| 2012-07-27 | Rick Porcello | R | 24 | L 3-8 | @ TOR | 20 | 109 | L | 6.0 | 6 | 5 | 5 | 0 | 2 | 1 | 86 | 32 | 54 | 63% | 7-6 | 4.58 | 1.52 |
| 2012-07-28 | Anibal Sanchez | R | 28 | L 1-5 | @ TOR | 20 | 133 | L | 6.0 | 8 | 5 | 5 | 3 | 3 | 3 | 110 | 39 | 71 | 65% | 5-8 | 4.11 | 1.28 |
| 2012-07-29 | Doug Fister | R | 28 | W 4-1 | @ TOR | 15 | 84 | W | 8.0 | 7 | 1 | 1 | 0 | 2 | 9 | 116 | 42 | 74 | 64% | 5-7 | 3.76 | 1.25 |
| 2012-07-30 | Max Scherzer | R | 28 | L 3-7 | @ BOS | 21 | 122 | L | 6.1 | 7 | 5 | 5 | 1 | 2 | 9 | 101 | 34 | 67 | 66% | 10-6 | 4.61 | 1.37 |
| 2012-07-31 | Justin Verlander | R | 29 | L 1-4 | @ BOS | 22 | 221 | L | 5.0 | 6 | 4 | 3 | 0 | 4 | 6 | 107 | 44 | 63 | 59% | 11-7 | 2.63 | 0.98 |
| 2012-08-01 | Rick Porcello | R | 24 | W 7-5 | @ BOS | 21 | 110 | W | 5.2 | 8 | 4 | 4 | 0 | 2 | 6 | 87 | 33 | 54 | 62% | 8-6 | 4.65 | 1.52 |
| 2012-08-03 | Anibal Sanchez | R | 28 | L 10-2 | vs CLE | 21 | 134 | W | 6.0 | 8 | 2 | 1 | 0 | 2 | 5 | 102 | 40 | 62 | 61% | 6-8 | 3.99 | 1.30 |
| 2012-08-04 | Doug Fister | R | 28 | L 6-1 | vs CLE | 16 | 85 | W | 9.0 | 4 | 1 | 1 | 0 | 0 | 6 | 107 | 34 | 73 | 68% | 6-7 | 3.51 | 1.18 |
| 2012-08-05 | Max Scherzer | R | 28 | L 10-8 | vs CLE | 22 | 123 | - | 5.0 | 10 | 4 | 4 | 1 | 1 | 9 | 105 | 38 | 67 | 64% | 10-6 | 4.71 | 1.41 |
| 2012-08-06 | Justin Verlander | R | 29 | L 7-2 | vs NYA | 23 | 222 | W | 8.0 | 9 | 2 | 0 | 0 | 1 | 14 | 131 | 36 | 95 | 73% | 12-7 | 2.50 | 0.99 |
| 2012-08-07 | Rick Porcello | R | 24 | L 6-5 | vs NYA | 22 | 111 | W | 6.2 | 8 | 3 | 3 | 1 | 0 | 3 | 101 | 37 | 64 | 63% | 9-6 | 4.60 | 1.50 |
| 2012-08-08 | Anibal Sanchez | R | 28 | W 8-12 | vs NYA | 22 | 135 | L | 3.0 | 7 | 7 | 7 | 1 | 2 | 2 | 64 | 25 | 39 | 61% | 6-9 | 4.37 | 1.34 |
| 2012-08-09 | Doug Fister | R | 29 | W 3-4 | vs NYA | 17 | 86 | - | 6.1 | 8 | 2 | 2 | 0 | 1 | 4 | 107 | 42 | 65 | 61% | 6-7 | 3.48 | 1.20 |
| 2012-08-10 | Max Scherzer | R | 28 | W 6-2 | @ TEX | 23 | 124 | W | 6.0 | 8 | 2 | 2 | 1 | 2 | 8 | 112 | 43 | 69 | 62% | 11-6 | 4.63 | 1.42 |
| 2012-08-11 | Justin Verlander | R | 29 | L 1-2 | @ TEX | 24 | 223 | - | 7.0 | 7 | 1 | 1 | 0 | 0 | 8 | 117 | 32 | 85 | 73% | 12-7 | 2.45 | 0.99 |
| 2012-08-12 | Rick Porcello | R | 24 | L 3-8 | @ TEX | 23 | 112 | L | 6.0 | 9 | 6 | 4 | 1 | 0 | 1 | 92 | 31 | 61 | 66% | 9-7 | 4.67 | 1.50 |
| 2012-08-13 | Anibal Sanchez | R | 28 | L 3-9 | @ MIN | 23 | 136 | L | 5.1 | 12 | 5 | 5 | 1 | 1 | 3 | 107 | 38 | 69 | 64% | 6-10 | 4.53 | 1.38 |
| 2012-08-14 | Doug Fister | R | 29 | W 8-4 | @ MIN | 18 | 87 | W | 8.0 | 5 | 4 | 0 | 1 | 2 | 7 | 120 | 38 | 82 | 68% | 7-7 | 3.24 | 1.18 |
| 2012-08-15 | Max Scherzer | R | 28 | W 5-1 | @ MIN | 24 | 125 | W | 7.0 | 4 | 0 | 0 | 0 | 2 | 10 | 117 | 43 | 74 | 63% | 12-6 | 4.40 | 1.39 |
| 2012-08-17 | Justin Verlander | R | 29 | L 5-3 | vs BAL | 25 | 224 | - | 6.0 | 6 | 3 | 3 | 1 | 4 | 6 | 115 | 44 | 71 | 62% | 12-7 | 2.52 | 1.01 |
| 2012-08-18 | Rick Porcello | R | 24 | W 2-3 | vs BAL | 24 | 113 | L | 6.0 | 7 | 3 | 3 | 1 | 1 | 6 | 97 | 32 | 65 | 67% | 9-8 | 4.66 | 1.50 |
| 2012-08-19 | Doug Fister | R | 29 | W 5-7 | vs BAL | 19 | 88 | L | 3.2 | 8 | 7 | 7 | 1 | 3 | 6 | 82 | 31 | 51 | 62% | 7-8 | 3.66 | 1.23 |
| 2012-08-21 | Max Scherzer | R | 28 | L 5-3 | vs TOR | 25 | 126 | W | 7.0 | 5 | 1 | 1 | 1 | 2 | 8 | 112 | 44 | 68 | 61% | 13-6 | 4.26 | 1.37 |
| 2012-08-22 | Anibal Sanchez | R | 28 | L 3-2 | vs TOR | 24 | 137 | W | 6.2 | 5 | 2 | 1 | 0 | 2 | 6 | 101 | 38 | 63 | 62% | 7-10 | 4.38 | 1.36 |
| 2012-08-23 | Justin Verlander | R | 30 | L 3-2 | vs TOR | 26 | 225 | - | 9.0 | 4 | 2 | 2 | 1 | 2 | 12 | 113 | 39 | 74 | 65% | 12-7 | 2.50 | 0.99 |
| 2012-08-24 | Rick Porcello | R | 24 | W 1-2 | vs ANA | 25 | 114 | L | 6.0 | 7 | 2 | 2 | 0 | 1 | 6 | 100 | 35 | 65 | 65% | 9-9 | 4.59 | 1.49 |
| 2012-08-25 | Drew Smyly | L | 23 | L 5-3 | vs ANA | 16 | 16 | - | 6.0 | 4 | 3 | 1 | 1 | 2 | 6 | 97 | 37 | 60 | 62% | 4-3 | 4.24 | 1.26 |
| 2012-08-26 | Max Scherzer | R | 28 | L 5-2 | vs ANA | 26 | 127 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 9 | 120 | 37 | 83 | 69% | 14-6 | 4.12 | 1.35 |
| 2012-08-28 | Justin Verlander | R | 30 | L 8-9 | @ KCA | 27 | 226 | - | 5.2 | 12 | 8 | 8 | 0 | 3 | 6 | 119 | 40 | 79 | 66% | 12-7 | 2.80 | 1.05 |
| 2012-08-29 | Anibal Sanchez | R | 29 | L 0-1 | @ KCA | 25 | 138 | L | 7.0 | 7 | 1 | 1 | 0 | 0 | 1 | 119 | 42 | 77 | 65% | 7-11 | 4.24 | 1.35 |
| 2012-08-30 | Rick Porcello | R | 24 | L 1-2 | @ KCA | 26 | 115 | L | 5.0 | 8 | 2 | 2 | 1 | 2 | 4 | 100 | 38 | 62 | 62% | 9-10 | 4.56 | 1.51 |
| 2012-08-31 | Doug Fister | R | 29 | L 7-4 | vs CHA | 20 | 89 | - | 5.0 | 4 | 3 | 2 | 1 | 4 | 2 | 101 | 46 | 55 | 54% | 7-8 | 3.66 | 1.24 |
| 2012-09-01 | Max Scherzer | R | 28 | L 5-1 | vs CHA | 27 | 128 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 9 | 111 | 33 | 78 | 70% | 15-6 | 3.92 | 1.31 |
| 2012-09-02 | Justin Verlander | R | 30 | L 4-2 | vs CHA | 28 | 227 | W | 8.0 | 4 | 1 | 1 | 1 | 2 | 11 | 121 | 44 | 77 | 64% | 13-7 | 2.74 | 1.03 |
| 2012-09-03 | Anibal Sanchez | R | 29 | W 2-3 | vs CLE | 26 | 139 | - | 6.0 | 8 | 2 | 0 | 0 | 1 | 2 | 104 | 36 | 68 | 65% | 7-11 | 4.08 | 1.35 |
| 2012-09-04 | Rick Porcello | R | 24 | W 2-3 | vs CLE | 27 | 116 | L | 5.2 | 8 | 3 | 3 | 0 | 2 | 2 | 92 | 36 | 56 | 61% | 9-11 | 4.59 | 1.52 |
| 2012-09-05 | Doug Fister | R | 29 | L 7-1 | vs CLE | 21 | 90 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 6 | 107 | 39 | 68 | 64% | 8-8 | 3.53 | 1.22 |
| 2012-09-07 | Max Scherzer | R | 28 | L 2-3 | @ ANA | 28 | 129 | - | 8.0 | 5 | 2 | 2 | 0 | 0 | 9 | 106 | 31 | 75 | 71% | 15-6 | 3.84 | 1.28 |
| 2012-09-08 | Justin Verlander | R | 30 | L 1-6 | @ ANA | 29 | 228 | L | 6.0 | 9 | 6 | 6 | 1 | 2 | 3 | 101 | 39 | 62 | 61% | 13-8 | 2.91 | 1.06 |
| 2012-09-09 | Anibal Sanchez | R | 29 | L 2-3 | @ ANA | 27 | 140 | L | 7.0 | 7 | 3 | 3 | 2 | 0 | 6 | 100 | 33 | 67 | 67% | 7-12 | 4.07 | 1.34 |
| 2012-09-10 | Rick Porcello | R | 24 | L 1-6 | @ CHA | 28 | 117 | L | 5.1 | 5 | 4 | 3 | 2 | 1 | 4 | 92 | 31 | 61 | 66% | 9-12 | 4.58 | 1.50 |
| 2012-09-11 | Doug Fister | R | 29 | W 5-3 | @ CHA | 22 | 91 | W | 7.0 | 2 | 2 | 2 | 2 | 2 | 6 | 97 | 35 | 62 | 64% | 9-8 | 3.48 | 1.18 |
| 2012-09-12 | Max Scherzer | R | 28 | W 8-6 | @ CHA | 29 | 130 | W | 6.0 | 4 | 1 | 1 | 1 | 0 | 7 | 112 | 38 | 74 | 66% | 16-6 | 3.76 | 1.26 |
| 2012-09-14 | Justin Verlander | R | 30 | W 4-0 | @ CLE | 30 | 229 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 6 | 109 | 33 | 76 | 70% | 14-8 | 2.82 | 1.06 |
| 2012-09-15 | Anibal Sanchez | R | 29 | W 5-3 | @ CLE | 28 | 141 | W | 6.2 | 3 | 2 | 2 | 0 | 0 | 7 | 95 | 33 | 62 | 65% | 8-12 | 4.01 | 1.30 |
| 2012-09-16 | Rick Porcello | R | 24 | L 6-7 | @ CLE | 29 | 118 | - | 4.2 | 8 | 4 | 2 | 0 | 3 | 2 | 94 | 39 | 55 | 59% | 9-12 | 4.58 | 1.53 |
| 2012-09-17 | Doug Fister | R | 29 | L 4-5 | @ CHA | 23 | 92 | L | 4.0 | 8 | 5 | 4 | 0 | 2 | 2 | 91 | 39 | 52 | 57% | 9-9 | 3.64 | 1.22 |
| 2012-09-18 | Max Scherzer | R | 28 | L 12-2 | vs OAK | 30 | 131 | - | 2.0 | 2 | 1 | 1 | 0 | 2 | 4 | 44 | 19 | 25 | 57% | 16-6 | 3.77 | 1.27 |
| 2012-09-19 | Justin Verlander | R | 30 | L 6-2 | vs OAK | 31 | 230 | W | 6.0 | 5 | 0 | 0 | 0 | 3 | 5 | 122 | 44 | 78 | 64% | 15-8 | 2.74 | 1.06 |
| 2012-09-20 | Anibal Sanchez | R | 29 | W 4-12 | vs OAK | 29 | 142 | L | 5.2 | 6 | 6 | 5 | 1 | 2 | 8 | 106 | 36 | 70 | 66% | 8-13 | 4.15 | 1.31 |
| 2012-09-22 | Doug Fister | R | 29 | L 8-0 | vs MIN | 24 | 93 | W | 9.0 | 7 | 0 | 0 | 0 | 0 | 7 | 117 | 41 | 76 | 65% | 10-9 | 3.42 | 1.19 |
| 2012-09-23 | Max Scherzer | R | 28 | W 4-10 | vs MIN | 31 | 132 | L | 5.0 | 6 | 3 | 3 | 0 | 1 | 4 | 86 | 30 | 56 | 65% | 16-7 | 3.82 | 1.27 |
| 2012-09-23 | Drew Smyly | L | 23 | W 1-2 | vs MIN | 17 | 17 | - | 4.1 | 3 | 1 | 0 | 0 | 2 | 2 | 78 | 33 | 45 | 58% | 4-3 | 4.26 | 1.29 |
| 2012-09-24 | Justin Verlander | R | 30 | L 6-2 | vs KCA | 32 | 231 | W | 8.0 | 9 | 2 | 2 | 1 | 0 | 8 | 112 | 25 | 87 | 78% | 16-8 | 2.73 | 1.06 |
| 2012-09-25 | Anibal Sanchez | R | 29 | L 2-0 | vs KCA | 30 | 143 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 10 | 105 | 28 | 77 | 73% | 9-13 | 3.95 | 1.27 |
| 2012-09-26 | Rick Porcello | R | 24 | L 5-4 | vs KCA | 30 | 119 | - | 4.0 | 7 | 4 | 4 | 1 | 0 | 3 | 61 | 19 | 42 | 69% | 9-12 | 4.68 | 1.54 |
| 2012-09-27 | Doug Fister | R | 29 | L 5-4 | vs KCA | 25 | 94 | - | 7.2 | 5 | 3 | 2 | 0 | 0 | 10 | 99 | 29 | 70 | 71% | 10-9 | 3.38 | 1.17 |
| 2012-09-28 | Drew Smyly | L | 23 | L 2-4 | @ MIN | 18 | 18 | - | 5.1 | 2 | 0 | 0 | 0 | 1 | 5 | 92 | 33 | 59 | 64% | 4-3 | 4.00 | 1.24 |
| 2012-09-29 | Justin Verlander | R | 30 | W 6-4 | @ MIN | 33 | 232 | W | 7.0 | 4 | 1 | 0 | 0 | 2 | 8 | 123 | 44 | 79 | 64% | 17-8 | 2.65 | 1.06 |
| 2012-09-30 | Anibal Sanchez | R | 29 | W 2-1 | @ MIN | 31 | 144 | - | 6.1 | 7 | 1 | 1 | 0 | 1 | 4 | 107 | 40 | 67 | 63% | 9-13 | 3.86 | 1.27 |
| 2012-10-01 | Rick Porcello | R | 24 | W 6-3 | @ KCA | 31 | 120 | W | 5.0 | 4 | 1 | 1 | 1 | 3 | 3 | 92 | 35 | 57 | 62% | 10-12 | 4.60 | 1.53 |
| 2012-10-02 | Doug Fister | R | 29 | L 2-4 | @ KCA | 26 | 95 | L | 4.1 | 7 | 3 | 3 | 1 | 2 | 2 | 79 | 32 | 47 | 59% | 10-10 | 3.44 | 1.19 |
| 2012-10-03 | Max Scherzer | R | 28 | W 1-0 | @ KCA | 32 | 133 | - | 4.0 | 3 | 0 | 0 | 0 | 2 | 3 | 80 | 25 | 55 | 69% | 16-7 | 3.73 | 1.27 |