| 2012-04-06 | vs KCA | 1 | W 5-0 | 1-0 | 1 | 44,106 | Jered Weaver | Bruce Chen | Jered Weaver | Aaron Crow | | 5 | 0 | 5 |
| 2012-04-07 | vs KCA | 2 | L 3-6 | 1-1 | 2 | 40,022 | Dan Haren | Luke Hochevar | Luke Hochevar | Dan Haren | | 8 | 6 | 2 |
| 2012-04-08 | vs KCA | 3 | L 3-7 | 1-2 | 3 | 32,227 | Ervin Santana | Jonathan Sanchez | Jonathan Sanchez | Ervin Santana | Jonathan Broxton | 11 | 13 | -2 |
| 2012-04-09 | @ MIN | 4 | W 5-1 | 2-2 | 2 | 39,414 | C.J. Wilson | Nick Blackburn | C.J. Wilson | Nick Blackburn | | 16 | 14 | 2 |
| 2012-04-11 | @ MIN | 5 | L 5-6 | 2-3 | 4 | 31,413 | Jered Weaver | Carl Pavano | Jeff Gray | Hisanori Takahashi | Matt Capps | 21 | 20 | 1 |
| 2012-04-12 | @ MIN | 6 | W 9-10 | 3-3 | 3 | 31,782 | Dan Haren | Francisco Liriano | Jeff Gray | Rich Thompson | Matt Capps | 30 | 30 | 0 |
| 2012-04-13 | @ NYA | 7 | L 0-5 | 3-4 | 4 | 49,386 | Ervin Santana | Hiroki Kuroda | Hiroki Kuroda | Ervin Santana | | 30 | 35 | -5 |
| 2012-04-14 | @ NYA | 8 | W 7-1 | 4-4 | 3 | 46,829 | C.J. Wilson | Phil Hughes | C.J. Wilson | Phil Hughes | | 37 | 36 | 1 |
| 2012-04-15 | @ NYA | 9 | W 5-11 | 5-4 | 3 | 41,055 | Jerome Williams | Ivan Nova | Ivan Nova | Jerome Williams | | 42 | 47 | -5 |
| 2012-04-16 | vs OAK | 10 | W 6-0 | 6-4 | 3 | 27,338 | Jered Weaver | Brandon McCarthy | Jered Weaver | Brandon McCarthy | | 48 | 47 | 1 |
| 2012-04-17 | vs OAK | 11 | L 3-5 | 6-5 | 3 | 41,016 | Dan Haren | Tyson Ross | Brian Fuentes | Kevin Jepsen | Grant Balfour | 51 | 52 | -1 |
| 2012-04-18 | vs OAK | 12 | L 0-6 | 6-6 | 3 | 27,217 | Ervin Santana | Bartolo Colon | Bartolo Colon | Ervin Santana | | 51 | 58 | -7 |
| 2012-04-19 | vs OAK | 13 | L 2-4 | 6-7 | 4 | 27,864 | C.J. Wilson | Tom Milone | Tom Milone | C.J. Wilson | Grant Balfour | 53 | 62 | -9 |
| 2012-04-20 | vs BAL | 14 | W 6-3 | 7-7 | 3 | 32,272 | Jerome Williams | Brian Matusz | Jerome Williams | Brian Matusz | Jordan Walden | 59 | 65 | -6 |
| 2012-04-21 | vs BAL | 15 | W 6-3 | 8-7 | 2 | 38,054 | Jered Weaver | Jake Arrieta | Jered Weaver | Jake Arrieta | | 65 | 68 | -3 |
| 2012-04-22 | vs BAL | 16 | L 2-3 | 8-8 | 2 | 38,221 | Dan Haren | Wei-Yin Chen | Pedro Strop | LaTroy Hawkins | Jim Johnson | 67 | 71 | -4 |
| 2012-04-24 | @ TBA | 17 | L 0-5 | 8-9 | 4 | 14,933 | Ervin Santana | David Price | David Price | Ervin Santana | | 67 | 76 | -9 |
| 2012-04-25 | @ TBA | 18 | L 2-3 | 8-10 | 4 | 14,638 | C.J. Wilson | Jeremy Hellickson | Jeremy Hellickson | C.J. Wilson | Fernando Rodney | 69 | 79 | -10 |
| 2012-04-26 | @ TBA | 19 | L 3-4 | 8-11 | 4 | 15,417 | Jerome Williams | Matt Moore | Brandon Gomes | Jordan Walden | | 72 | 83 | -11 |
| 2012-04-27 | @ CLE | 20 | L 2-3 | 8-12 | 4 | 12,597 | Jered Weaver | Justin Masterson | Vinnie Pestano | David Carpenter | | 74 | 86 | -12 |
| 2012-04-28 | @ CLE | 21 | W 2-1 | 9-12 | 4 | 11,316 | Dan Haren | Jeanmar Gomez | Dan Haren | Jeanmar Gomez | Scott Downs | 76 | 87 | -11 |
| 2012-04-29 | @ CLE | 22 | L 0-4 | 9-13 | 4 | 15,421 | Ervin Santana | Derek Lowe | Derek Lowe | Ervin Santana | | 76 | 91 | -15 |
| 2012-04-30 | vs MIN | 23 | W 4-3 | 10-13 | 4 | 27,027 | C.J. Wilson | Nick Blackburn | C.J. Wilson | Nick Blackburn | Scott Downs | 80 | 94 | -14 |
| 2012-05-01 | vs MIN | 24 | W 4-0 | 11-13 | 4 | 30,039 | Jerome Williams | Francisco Liriano | Jerome Williams | Francisco Liriano | | 84 | 94 | -10 |
| 2012-05-02 | vs MIN | 25 | W 9-0 | 12-13 | 3 | 27,288 | Jered Weaver | Liam Hendriks | Jered Weaver | Liam Hendriks | | 93 | 94 | -1 |
| 2012-05-03 | vs TOR | 26 | L 0-5 | 12-14 | 3 | 28,359 | Dan Haren | Brandon Morrow | Brandon Morrow | Dan Haren | | 93 | 99 | -6 |
| 2012-05-04 | vs TOR | 27 | L 0-4 | 12-15 | 3 | 33,160 | Ervin Santana | Henderson Alvarez | Henderson Alvarez | Ervin Santana | | 93 | 103 | -10 |
| 2012-05-05 | vs TOR | 28 | W 6-2 | 13-15 | 3 | 39,018 | C.J. Wilson | Kyle Drabek | C.J. Wilson | Kyle Drabek | | 99 | 105 | -6 |
| 2012-05-06 | vs TOR | 29 | W 4-3 | 14-15 | 3 | 37,548 | Jerome Williams | Drew Hutchison | Jerome Williams | Drew Hutchison | LaTroy Hawkins | 103 | 108 | -5 |
| 2012-05-07 | @ MIN | 30 | W 8-3 | 15-15 | 3 | 31,382 | Jered Weaver | Francisco Liriano | Jered Weaver | Francisco Liriano | | 111 | 111 | 0 |
| 2012-05-08 | @ MIN | 31 | L 0-5 | 15-16 | 3 | 30,776 | Dan Haren | Scott Diamond | Scott Diamond | Dan Haren | | 111 | 116 | -5 |
| 2012-05-09 | @ MIN | 32 | W 6-2 | 16-16 | 2 | 31,915 | Ervin Santana | Carl Pavano | Ervin Santana | Carl Pavano | | 117 | 118 | -1 |
| 2012-05-11 | @ TEX | 33 | W 3-10 | 17-16 | 2 | 48,201 | C.J. Wilson | Yu Darvish | Yu Darvish | C.J. Wilson | | 120 | 128 | -8 |
| 2012-05-12 | @ TEX | 34 | W 4-2 | 18-16 | 2 | 47,699 | C.J. Wilson | Matt Harrison | David Carpenter | Matt Harrison | Scott Downs | 124 | 130 | -6 |
| 2012-05-13 | @ TEX | 35 | W 6-13 | 19-16 | 1 | 46,669 | Jered Weaver | Neftali Feliz | Neftali Feliz | Jered Weaver | | 130 | 143 | -13 |
| 2012-05-14 | vs OAK | 36 | L 0-5 | 19-17 | 2 | 32,851 | Dan Haren | Tyson Ross | Tyson Ross | Dan Haren | | 130 | 148 | -18 |
| 2012-05-15 | vs OAK | 37 | W 4-0 | 20-17 | 1 | 31,762 | Ervin Santana | Bartolo Colon | Ervin Santana | Bartolo Colon | | 134 | 148 | -14 |
| 2012-05-16 | vs CHA | 38 | W 7-2 | 21-17 | 1 | 39,027 | Jerome Williams | Gavin Floyd | Jerome Williams | Gavin Floyd | | 141 | 150 | -9 |
| 2012-05-17 | vs CHA | 39 | L 1-6 | 21-18 | 1 | 30,786 | C.J. Wilson | Chris Sale | Chris Sale | C.J. Wilson | | 142 | 156 | -14 |
| 2012-05-18 | @ SDN | 40 | W 7-2 | 22-18 | 1 | 31,389 | Jered Weaver | Jeff Suppan | Jered Weaver | Jeff Suppan | | 149 | 158 | -9 |
| 2012-05-19 | @ SDN | 41 | L 2-3 | 22-19 | 1 | 43,427 | Dan Haren | Eric Stults | Luke Gregerson | Dan Haren | Dale Thayer | 151 | 161 | -10 |
| 2012-05-20 | @ SDN | 42 | L 2-3 | 22-20 | 1 | 33,975 | Ervin Santana | Anthony Bass | Miles Mikolas | David Pauley | | 153 | 164 | -11 |
| 2012-05-21 | @ OAK | 43 | L 1-2 | 22-21 | 2 | 11,292 | Jerome Williams | Tom Milone | Tom Milone | Jerome Williams | Brian Fuentes | 154 | 166 | -12 |
| 2012-05-22 | @ OAK | 44 | W 5-0 | 23-21 | 1 | 12,894 | C.J. Wilson | Graham Godfrey | C.J. Wilson | Graham Godfrey | | 159 | 166 | -7 |
| 2012-05-23 | @ OAK | 45 | W 3-1 | 24-21 | 1 | 23,617 | Jered Weaver | Jarrod Parker | Jordan Walden | Jordan Norberto | Ernesto Frieri | 162 | 167 | -5 |
| 2012-05-24 | @ SEA | 46 | W 3-0 | 25-21 | 1 | 18,048 | Dan Haren | Jason Vargas | Dan Haren | Jason Vargas | | 165 | 167 | -2 |
| 2012-05-25 | @ SEA | 47 | W 6-4 | 26-21 | 1 | 23,517 | Ervin Santana | Blake Beavan | Jason Isringhausen | Brandon League | Scott Downs | 171 | 171 | 0 |
| 2012-05-26 | @ SEA | 48 | W 5-3 | 27-21 | 1 | 29,483 | Jerome Williams | Felix Hernandez | Jerome Williams | Felix Hernandez | Ernesto Frieri | 176 | 174 | 2 |
| 2012-05-27 | @ SEA | 49 | W 4-2 | 28-21 | 1 | 24,467 | C.J. Wilson | Hector Noesi | C.J. Wilson | Hector Noesi | Scott Downs | 180 | 176 | 4 |
| 2012-05-28 | vs NYA | 50 | W 9-8 | 29-21 | 1 | 44,016 | Jered Weaver | Phil Hughes | Jordan Walden | Cory Wade | | 189 | 184 | 5 |
| 2012-05-29 | vs NYA | 51 | W 5-1 | 30-21 | 1 | 42,065 | Dan Haren | Andy Pettitte | Dan Haren | Andy Pettitte | | 194 | 185 | 9 |
| 2012-05-30 | vs NYA | 52 | L 5-6 | 30-22 | 1 | 40,111 | Ervin Santana | Ivan Nova | Ivan Nova | Hisanori Takahashi | Rafael Soriano | 199 | 191 | 8 |
| 2012-06-01 | vs TEX | 53 | W 4-2 | 31-22 | 1 | 40,080 | Jerome Williams | Colby Lewis | Jerome Williams | Colby Lewis | Ernesto Frieri | 203 | 193 | 10 |
| 2012-06-02 | vs TEX | 54 | W 3-2 | 32-22 | 1 | 44,227 | C.J. Wilson | Yu Darvish | Bobby Cassevah | Yu Darvish | Ernesto Frieri | 206 | 195 | 11 |
| 2012-06-03 | vs TEX | 55 | L 3-7 | 32-23 | 1 | 42,465 | Dan Haren | Matt Harrison | Matt Harrison | Dan Haren | | 209 | 202 | 7 |
| 2012-06-04 | vs SEA | 56 | L 6-8 | 32-24 | 1 | 36,079 | Ervin Santana | Jason Vargas | Jason Vargas | Ervin Santana | Tom Wilhelmsen | 215 | 210 | 5 |
| 2012-06-05 | vs SEA | 57 | W 6-1 | 33-24 | 1 | 35,021 | Garrett Richards | Blake Beavan | Garrett Richards | Blake Beavan | | 221 | 211 | 10 |
| 2012-06-06 | vs SEA | 58 | L 6-8 | 33-25 | 1 | 37,342 | Jerome Williams | Hector Noesi | Shawn Kelley | Jerome Williams | Tom Wilhelmsen | 227 | 219 | 8 |
| 2012-06-08 | @ COL | 59 | W 7-2 | 34-25 | 1 | 41,814 | C.J. Wilson | Alex White | C.J. Wilson | Alex White | | 234 | 221 | 13 |
| 2012-06-09 | @ COL | 60 | L 11-5 | 34-26 | 1 | 37,801 | Dan Haren | Jeff Francis | Dan Haren | Jeff Francis | | 245 | 226 | 19 |
| 2012-06-10 | @ COL | 61 | L 10-8 | 34-27 | 1 | 37,722 | Ervin Santana | Christian Friedrich | Ervin Santana | Christian Friedrich | Scott Downs | 255 | 234 | 21 |
| 2012-06-11 | @ LAN | 62 | W 3-2 | 35-27 | 1 | 50,559 | Garrett Richards | Chris Capuano | Jason Isringhausen | Kenley Jansen | Ernesto Frieri | 258 | 236 | 22 |
| 2012-06-12 | @ LAN | 63 | L 2-5 | 35-28 | 1 | 55,279 | Jerome Williams | Aaron Harang | Jamey Wright | Jerome Williams | Kenley Jansen | 260 | 241 | 19 |
| 2012-06-13 | @ LAN | 64 | W 2-1 | 36-28 | 1 | 43,494 | C.J. Wilson | Nathan Eovaldi | LaTroy Hawkins | Kenley Jansen | Ernesto Frieri | 262 | 242 | 20 |
| 2012-06-15 | vs ARI | 65 | L 0-5 | 36-29 | 1 | 37,096 | Dan Haren | Trevor Cahill | Trevor Cahill | Dan Haren | | 262 | 247 | 15 |
| 2012-06-16 | vs ARI | 66 | W 2-0 | 37-29 | 1 | 42,483 | Ervin Santana | Joe Saunders | Ervin Santana | Joe Saunders | | 264 | 247 | 17 |
| 2012-06-17 | vs ARI | 67 | W 2-0 | 38-29 | 1 | 42,222 | Garrett Richards | Ian Kennedy | Garrett Richards | Ian Kennedy | Ernesto Frieri | 266 | 247 | 19 |
| 2012-06-18 | vs SFN | 68 | L 3-5 | 38-30 | 1 | 41,234 | Jerome Williams | Matt Cain | Matt Cain | Jerome Williams | Santiago Casilla | 269 | 252 | 17 |
| 2012-06-19 | vs SFN | 69 | L 12-5 | 38-31 | 1 | 38,010 | C.J. Wilson | Barry Zito | C.J. Wilson | Barry Zito | | 281 | 257 | 24 |
| 2012-06-20 | vs SFN | 70 | W 6-0 | 39-31 | 1 | 40,321 | Jered Weaver | Ryan Vogelsong | Jered Weaver | Ryan Vogelsong | | 287 | 257 | 30 |
| 2012-06-22 | vs LAN | 71 | W 8-5 | 40-31 | 1 | 44,548 | Dan Haren | Chad Billingsley | Dan Haren | Chad Billingsley | Ernesto Frieri | 295 | 262 | 33 |
| 2012-06-23 | vs LAN | 72 | L 1-3 | 40-32 | 1 | 44,512 | Ervin Santana | Chris Capuano | Chris Capuano | Ervin Santana | Kenley Jansen | 296 | 265 | 31 |
| 2012-06-24 | vs LAN | 73 | W 5-3 | 41-32 | 1 | 43,975 | Garrett Richards | Aaron Harang | Scott Downs | Josh Lindblom | Ernesto Frieri | 301 | 268 | 33 |
| 2012-06-26 | @ BAL | 74 | W 7-3 | 42-32 | 1 | 24,296 | C.J. Wilson | Brian Matusz | C.J. Wilson | Brian Matusz | | 308 | 271 | 37 |
| 2012-06-27 | @ BAL | 75 | W 13-1 | 43-32 | 1 | 18,055 | Jered Weaver | Jason Hammel | Jered Weaver | Jason Hammel | | 321 | 272 | 49 |
| 2012-06-28 | @ TOR | 76 | W 9-7 | 44-32 | 1 | 24,668 | Dan Haren | Brett Cecil | Dan Haren | Brett Cecil | Ernesto Frieri | 330 | 279 | 51 |
| 2012-06-29 | @ TOR | 77 | L 5-7 | 44-33 | 1 | 24,538 | Ervin Santana | Carlos Villanueva | Francisco Cordero | Jordan Walden | Casey Janssen | 335 | 286 | 49 |
| 2012-06-30 | @ TOR | 78 | W 2-11 | 45-33 | 1 | 29,287 | Garrett Richards | Henderson Alvarez | Henderson Alvarez | Garrett Richards | | 337 | 297 | 40 |
| 2012-07-01 | @ TOR | 79 | L 10-6 | 45-34 | 1 | 34,853 | C.J. Wilson | Aaron Laffey | Jason Isringhausen | Francisco Cordero | | 347 | 303 | 44 |
| 2012-07-02 | @ CLE | 80 | W 3-0 | 46-34 | 1 | 21,616 | Jered Weaver | Ubaldo Jimenez | Jered Weaver | Ubaldo Jimenez | Scott Downs | 350 | 303 | 47 |
| 2012-07-03 | @ CLE | 81 | L 5-9 | 46-35 | 1 | 29,292 | Dan Haren | Zach McAllister | Zach McAllister | Dan Haren | | 355 | 312 | 43 |
| 2012-07-04 | @ CLE | 82 | W 3-12 | 47-35 | 1 | 20,979 | Ervin Santana | Derek Lowe | Derek Lowe | Ervin Santana | | 358 | 324 | 34 |
| 2012-07-05 | vs BAL | 83 | W 9-7 | 48-35 | 1 | 38,104 | Garrett Richards | Jake Arrieta | LaTroy Hawkins | Luis Ayala | Ernesto Frieri | 367 | 331 | 36 |
| 2012-07-06 | vs BAL | 84 | L 2-3 | 48-36 | 1 | 42,716 | C.J. Wilson | Miguel Gonzalez | Miguel Gonzalez | C.J. Wilson | Jim Johnson | 369 | 334 | 35 |
| 2012-07-07 | vs BAL | 85 | W 3-0 | 49-36 | 1 | 41,147 | Jered Weaver | Jason Hammel | Jered Weaver | Jason Hammel | Scott Downs | 372 | 334 | 38 |
| 2012-07-08 | vs BAL | 86 | W 6-0 | 50-36 | 1 | 37,108 | Brad Mills | Wei-Yin Chen | Brad Mills | Wei-Yin Chen | | 378 | 334 | 44 |
| 2012-07-13 | @ NYA | 87 | L 5-6 | 50-37 | 1 | 47,873 | C.J. Wilson | Hiroki Kuroda | Chad Qualls | Scott Downs | Rafael Soriano | 383 | 340 | 43 |
| 2012-07-14 | @ NYA | 88 | L 3-5 | 50-38 | 1 | 47,789 | Jerome Williams | Freddy Garcia | Freddy Garcia | Jerome Williams | Rafael Soriano | 386 | 345 | 41 |
| 2012-07-15 | @ NYA | 89 | L 10-8 | 50-39 | 1 | 46,679 | Jered Weaver | Ivan Nova | Jered Weaver | Ivan Nova | Kevin Jepsen | 396 | 353 | 43 |
| 2012-07-16 | @ DET | 90 | L 6-8 | 50-40 | 1 | 36,806 | Ervin Santana | Rick Porcello | Octavio Dotel | LaTroy Hawkins | Jose Valverde | 402 | 361 | 41 |
| 2012-07-17 | @ DET | 91 | W 13-0 | 51-40 | 1 | 33,950 | Garrett Richards | Jacob Turner | Garrett Richards | Jacob Turner | | 415 | 361 | 54 |
| 2012-07-18 | @ DET | 92 | L 2-7 | 51-41 | 1 | 37,915 | C.J. Wilson | Doug Fister | Doug Fister | C.J. Wilson | | 417 | 368 | 49 |
| 2012-07-19 | @ DET | 93 | L 1-5 | 51-42 | 2 | 40,311 | Jerome Williams | Max Scherzer | Max Scherzer | Jerome Williams | | 418 | 373 | 45 |
| 2012-07-20 | vs TEX | 94 | W 6-1 | 52-42 | 1 | 43,936 | Jered Weaver | Derek Holland | Jered Weaver | Derek Holland | | 424 | 374 | 50 |
| 2012-07-21 | vs TEX | 95 | L 2-9 | 52-43 | 2 | 39,086 | Ervin Santana | Yu Darvish | Yu Darvish | Ervin Santana | | 426 | 383 | 43 |
| 2012-07-22 | vs TEX | 96 | W 7-4 | 53-43 | 1 | 42,160 | Dan Haren | Matt Harrison | Dan Haren | Matt Harrison | | 433 | 387 | 46 |
| 2012-07-23 | vs KCA | 97 | W 6-3 | 54-43 | 1 | 35,047 | C.J. Wilson | Bruce Chen | Kevin Jepsen | Greg Holland | Scott Downs | 439 | 390 | 49 |
| 2012-07-24 | vs KCA | 98 | L 1-4 | 54-44 | 1 | 35,051 | Garrett Richards | Will Smith | Will Smith | Garrett Richards | Jonathan Broxton | 440 | 394 | 46 |
| 2012-07-25 | vs KCA | 99 | L 11-6 | 54-45 | 2 | 39,107 | Jered Weaver | Luke Hochevar | Jered Weaver | Luke Hochevar | | 451 | 400 | 51 |
| 2012-07-27 | vs TBA | 100 | W 3-1 | 55-45 | 1 | 40,136 | Dan Haren | Alex Cobb | Dan Haren | Alex Cobb | Ernesto Frieri | 454 | 401 | 53 |
| 2012-07-28 | vs TBA | 101 | L 0-3 | 55-46 | 1 | 41,232 | C.J. Wilson | Matt Moore | Matt Moore | C.J. Wilson | Fernando Rodney | 454 | 404 | 50 |
| 2012-07-29 | vs TBA | 102 | L 0-2 | 55-47 | 2 | 35,477 | Zack Greinke | Jeremy Hellickson | Jeremy Hellickson | Zack Greinke | Fernando Rodney | 454 | 406 | 48 |
| 2012-07-30 | @ TEX | 103 | L 15-8 | 55-48 | 3 | 36,111 | Ervin Santana | Roy Oswalt | Ervin Santana | Roy Oswalt | Jerome Williams | 469 | 414 | 55 |
| 2012-07-31 | @ TEX | 104 | W 6-2 | 56-48 | 2 | 34,918 | Jered Weaver | Derek Holland | Jered Weaver | Derek Holland | | 475 | 416 | 59 |
| 2012-08-01 | @ TEX | 105 | L 10-11 | 56-49 | 2 | 42,832 | Garrett Richards | Yu Darvish | Joe Nathan | Jason Isringhausen | | 485 | 427 | 58 |
| 2012-08-02 | @ TEX | 106 | W 9-15 | 57-49 | 2 | 40,281 | C.J. Wilson | Ryan Dempster | Roy Oswalt | David Carpenter | | 494 | 442 | 52 |
| 2012-08-03 | @ CHA | 107 | L 6-8 | 57-50 | 3 | 32,060 | Zack Greinke | Philip Humber | Matt Thornton | Hisanori Takahashi | | 500 | 450 | 50 |
| 2012-08-04 | @ CHA | 108 | W 6-5 | 58-50 | 2 | 28,571 | Ervin Santana | Gavin Floyd | Kevin Jepsen | Matt Thornton | Ernesto Frieri | 506 | 455 | 51 |
| 2012-08-05 | @ CHA | 109 | L 2-4 | 58-51 | 2 | 30,202 | Dan Haren | Francisco Liriano | Nate Jones | Jason Isringhausen | Addison Reed | 508 | 459 | 49 |
| 2012-08-06 | @ OAK | 110 | W 4-0 | 59-51 | 2 | 13,341 | Jered Weaver | Jarrod Parker | Jered Weaver | Jarrod Parker | | 512 | 459 | 53 |
| 2012-08-07 | @ OAK | 111 | W 4-10 | 60-51 | 2 | 15,458 | C.J. Wilson | Bartolo Colon | Bartolo Colon | C.J. Wilson | | 516 | 469 | 47 |
| 2012-08-08 | @ OAK | 112 | L 8-9 | 60-52 | 2 | 21,150 | Zack Greinke | Dan Straily | Pat Neshek | LaTroy Hawkins | Ryan Cook | 524 | 478 | 46 |
| 2012-08-10 | vs SEA | 113 | W 6-5 | 61-52 | 1 | 39,016 | Ervin Santana | Felix Hernandez | Ernesto Frieri | Josh Kinney | | 530 | 483 | 47 |
| 2012-08-11 | vs SEA | 114 | L 4-7 | 61-53 | 2 | 38,722 | Dan Haren | Hisashi Iwakuma | Hisashi Iwakuma | Dan Haren | | 534 | 490 | 44 |
| 2012-08-12 | vs SEA | 115 | L 1-4 | 61-54 | 2 | 36,505 | Jered Weaver | Jason Vargas | Jason Vargas | Jered Weaver | Tom Wilhelmsen | 535 | 494 | 41 |
| 2012-08-13 | vs CLE | 116 | L 2-6 | 61-55 | 2 | 36,620 | C.J. Wilson | Justin Masterson | Justin Masterson | C.J. Wilson | Chris Perez | 537 | 500 | 37 |
| 2012-08-14 | vs CLE | 117 | W 9-6 | 62-55 | 2 | 39,827 | Zack Greinke | Ubaldo Jimenez | Zack Greinke | Ubaldo Jimenez | Ernesto Frieri | 546 | 506 | 40 |
| 2012-08-15 | vs CLE | 118 | W 8-4 | 63-55 | 1 | 37,554 | Ervin Santana | Fausto Carmona | Ervin Santana | Fausto Carmona | | 554 | 510 | 44 |
| 2012-08-16 | vs TBA | 119 | L 0-7 | 63-56 | 1 | 38,591 | Dan Haren | David Price | David Price | Dan Haren | | 554 | 517 | 37 |
| 2012-08-17 | vs TBA | 120 | W 3-12 | 64-56 | 1 | 37,298 | Jered Weaver | James Shields | James Shields | Jered Weaver | | 557 | 529 | 28 |
| 2012-08-18 | vs TBA | 121 | W 8-10 | 65-56 | 1 | 41,086 | C.J. Wilson | Alex Cobb | Jake McGee | Kevin Jepsen | Fernando Rodney | 565 | 539 | 26 |
| 2012-08-19 | vs TBA | 122 | L 3-8 | 65-57 | 1 | 36,789 | Zack Greinke | Matt Moore | Matt Moore | Zack Greinke | | 568 | 547 | 21 |
| 2012-08-21 | @ BOS | 123 | W 5-3 | 66-57 | 1 | 37,794 | Ervin Santana | Aaron Cook | Ervin Santana | Aaron Cook | Ernesto Frieri | 573 | 550 | 23 |
| 2012-08-22 | @ BOS | 124 | W 7-3 | 67-57 | 1 | 37,373 | Jered Weaver | Clay Buchholz | Jered Weaver | Clay Buchholz | | 580 | 553 | 27 |
| 2012-08-23 | @ BOS | 125 | W 14-13 | 68-57 | 1 | 37,829 | C.J. Wilson | Franklin Morales | Ernesto Frieri | Alfredo Aceves | | 594 | 566 | 28 |
| 2012-08-24 | @ DET | 126 | W 2-1 | 69-57 | 1 | 39,356 | Zack Greinke | Rick Porcello | Zack Greinke | Rick Porcello | Garrett Richards | 596 | 567 | 29 |
| 2012-08-25 | @ DET | 127 | L 3-5 | 69-58 | 1 | 41,970 | Dan Haren | Drew Smyly | Octavio Dotel | Garrett Richards | Jose Valverde | 599 | 572 | 27 |
| 2012-08-26 | @ DET | 128 | L 2-5 | 69-59 | 1 | 40,074 | Ervin Santana | Max Scherzer | Max Scherzer | Ervin Santana | | 601 | 577 | 24 |
| 2012-08-28 | vs BOS | 129 | W 6-5 | 70-59 | 1 | 38,745 | Jered Weaver | Clay Buchholz | Kevin Jepsen | Alfredo Aceves | | 607 | 582 | 25 |
| 2012-08-29 | vs BOS | 130 | L 10-3 | 70-60 | 2 | 37,841 | C.J. Wilson | Zach Stewart | C.J. Wilson | Zach Stewart | | 617 | 585 | 32 |
| 2012-08-30 | vs BOS | 131 | W 5-2 | 71-60 | 1 | 39,013 | Zack Greinke | Jon Lester | Zack Greinke | Jon Lester | Ernesto Frieri | 622 | 587 | 35 |
| 2012-08-31 | @ SEA | 132 | W 9-1 | 72-60 | 1 | 17,739 | Dan Haren | Kevin Millwood | Dan Haren | Kevin Millwood | | 631 | 588 | 43 |
| 2012-09-01 | @ SEA | 133 | W 5-2 | 73-60 | 1 | 22,910 | Ervin Santana | Felix Hernandez | Ervin Santana | Felix Hernandez | Ernesto Frieri | 636 | 590 | 46 |
| 2012-09-02 | @ SEA | 134 | L 1-2 | 73-61 | 2 | 20,584 | Jered Weaver | Hisashi Iwakuma | Hisashi Iwakuma | Jered Weaver | Tom Wilhelmsen | 637 | 592 | 45 |
| 2012-09-03 | @ OAK | 135 | W 8-3 | 74-61 | 1 | 20,180 | C.J. Wilson | Tom Milone | C.J. Wilson | Tom Milone | | 645 | 595 | 50 |
| 2012-09-04 | @ OAK | 136 | W 6-1 | 75-61 | 1 | 11,688 | Zack Greinke | Jarrod Parker | Zack Greinke | Jarrod Parker | | 651 | 596 | 55 |
| 2012-09-05 | @ OAK | 137 | W 7-1 | 76-61 | 1 | 15,404 | Dan Haren | Brandon McCarthy | Dan Haren | Brandon McCarthy | | 658 | 597 | 61 |
| 2012-09-07 | vs DET | 138 | W 3-2 | 77-61 | 1 | 40,104 | Ervin Santana | Max Scherzer | Ernesto Frieri | Octavio Dotel | | 661 | 599 | 62 |
| 2012-09-08 | vs DET | 139 | W 6-1 | 78-61 | 1 | 41,154 | C.J. Wilson | Justin Verlander | C.J. Wilson | Justin Verlander | | 667 | 600 | 67 |
| 2012-09-09 | vs DET | 140 | W 3-2 | 79-61 | 1 | 38,216 | Zack Greinke | Anibal Sanchez | Zack Greinke | Anibal Sanchez | Ernesto Frieri | 670 | 602 | 68 |
| 2012-09-10 | vs OAK | 141 | L 1-3 | 79-62 | 1 | 36,064 | Dan Haren | Jarrod Parker | Jarrod Parker | Dan Haren | Grant Balfour | 671 | 605 | 66 |
| 2012-09-11 | vs OAK | 142 | L 5-6 | 79-63 | 1 | 37,794 | Jerome Williams | Dan Straily | Dan Straily | Jerome Williams | Jerry Blevins | 676 | 611 | 65 |
| 2012-09-12 | vs OAK | 143 | L 1-4 | 79-64 | 2 | 38,097 | Ervin Santana | A.J. Griffin | A.J. Griffin | Ervin Santana | Ryan Cook | 677 | 615 | 62 |
| 2012-09-13 | vs OAK | 144 | W 6-0 | 80-64 | 1 | 38,029 | Jered Weaver | Brett Anderson | Jered Weaver | Brett Anderson | | 683 | 615 | 68 |
| 2012-09-14 | @ KCA | 145 | W 9-7 | 81-64 | 1 | 27,586 | C.J. Wilson | Bruce Chen | Jordan Walden | Tim Collins | Ernesto Frieri | 692 | 622 | 70 |
| 2012-09-15 | @ KCA | 146 | L 2-3 | 81-65 | 2 | 23,027 | Zack Greinke | Jeremy Guthrie | Kelvin Herrera | Ernesto Frieri | | 694 | 625 | 69 |
| 2012-09-16 | @ KCA | 147 | W 4-3 | 82-65 | 1 | 24,979 | Dan Haren | Will Smith | Dan Haren | Will Smith | Kevin Jepsen | 698 | 628 | 70 |
| 2012-09-18 | vs TEX | 148 | L 11-3 | 82-66 | 2 | 36,948 | Jered Weaver | Ryan Dempster | Jered Weaver | Ryan Dempster | | 709 | 631 | 78 |
| 2012-09-19 | vs TEX | 149 | L 2-6 | 82-67 | 2 | 37,093 | C.J. Wilson | Derek Holland | Derek Holland | C.J. Wilson | | 711 | 637 | 74 |
| 2012-09-20 | vs TEX | 150 | L 1-3 | 82-68 | 2 | 38,205 | Zack Greinke | Yu Darvish | Yu Darvish | Ernesto Frieri | Joe Nathan | 712 | 640 | 72 |
| 2012-09-21 | vs CHA | 151 | W 6-2 | 83-68 | 1 | 39,326 | Ervin Santana | Jake Peavy | Ervin Santana | Jake Peavy | | 718 | 642 | 76 |
| 2012-09-22 | vs CHA | 152 | W 4-2 | 84-68 | 1 | 41,440 | Dan Haren | Jose Quintana | Dan Haren | Jose Quintana | Ernesto Frieri | 722 | 644 | 78 |
| 2012-09-23 | vs CHA | 153 | W 4-1 | 85-68 | 1 | 36,546 | Jered Weaver | Gavin Floyd | Jered Weaver | Gavin Floyd | | 726 | 645 | 81 |
| 2012-09-25 | vs SEA | 154 | W 5-4 | 86-68 | 1 | 38,538 | Zack Greinke | Erasmo Ramirez | Zack Greinke | Erasmo Ramirez | Ernesto Frieri | 731 | 649 | 82 |
| 2012-09-26 | vs SEA | 155 | W 4-3 | 87-68 | 1 | 37,916 | C.J. Wilson | Felix Hernandez | Ernesto Frieri | Stephen Pryor | | 735 | 652 | 83 |
| 2012-09-27 | vs SEA | 156 | L 4-9 | 87-69 | 1 | 37,377 | Dan Haren | Hisashi Iwakuma | Hisashi Iwakuma | Dan Haren | | 739 | 661 | 78 |
| 2012-09-28 | @ TEX | 157 | W 7-4 | 88-69 | 1 | 46,662 | Jered Weaver | Ryan Dempster | Jered Weaver | Ryan Dempster | Ernesto Frieri | 746 | 665 | 81 |
| 2012-09-30 | @ TEX | 158 | W 5-4 | 89-70 | 2 | 46,713 | Zack Greinke | Yu Darvish | Garrett Richards | Joe Nathan | Ernesto Frieri | 751 | 669 | 82 |
| 2012-09-30 | @ TEX | 159 | L 7-8 | 89-70 | 2 | 48,089 | Ervin Santana | Derek Holland | Derek Holland | Ervin Santana | Joe Nathan | 758 | 677 | 81 |
| 2012-10-01 | @ SEA | 160 | W 8-4 | 90-70 | 1 | 13,963 | C.J. Wilson | Felix Hernandez | C.J. Wilson | Felix Hernandez | | 766 | 681 | 85 |
| 2012-10-02 | @ SEA | 161 | L 1-6 | 90-71 | 2 | 14,353 | Dan Haren | Hisashi Iwakuma | Hisashi Iwakuma | Dan Haren | | 767 | 687 | 80 |
| 2012-10-03 | @ SEA | 162 | L 0-12 | 90-72 | 2 | 15,614 | Jered Weaver | Blake Beavan | Blake Beavan | Jered Weaver | | 767 | 699 | 68 |