| 23 | Michael Brantley | CF | MLB | 6-2 | 180 | Left | Left | 5/15/1987 | 24 | Bellevue,Washington | 2005 | 7 | 205 | MIL |
|
| 28 | Travis Buck | RF | MLB | 6-3 | 210 | Left | Left | 11/18/1983 | 27 | Richland,Washington | 2005 | 1 | 36 | OAK |
| 13 | Asdrubal Cabrera | SS | MLB | 6-0 | 185 | Both | Right | 11/13/1985 | 25 | Puerto La Cruz,Venezuela | 2002 | UDFA | | SEA |
| 20 | Orlando Cabrera | 2B | MLB | 5-10 | 175 | Right | Right | 11/2/1974 | 36 | Cartagena,Colombia | 1993 | UDFA | | MTL |
| 59 | Carlos Carrasco | P | MLB | 6-3 | 178 | Right | Right | 3/21/1987 | 24 | Barquisimeto,Venezuela | 2003 | UDFA | | PHI |
| 12 | Ezequiel Carrera | CF | MLB | 5-10 | 179 | Left | Left | 6/11/1987 | 24 | Guiria Sucre,Venezuela | 2007 | UDFA | | NYM |
| 27 | Lonnie Chisenhall | 3B | MLB | 6-1 | 200 | Left | Right | 10/4/1988 | 22 | Morehead City,North Carolina | 2008 | 1 | 29 | CLE |
| 17 | Shin-Soo Choo | RF | MLB | 5-11 | 178 | Left | Left | 7/30/1982 | 28 | Pusan,Korea | 2000 | UDFA | | SEA |
| 4 | Trevor Crowe | CF-RF | MLB | 6-0 | 190 | Both | Right | 11/17/1983 | 27 | Portland,Oregon | 2005 | 1 | 14 | CLE |
| 16 | Jason Donald | SS | MLB | 6-1 | 190 | Right | Right | 9/4/1984 | 26 | Fresno,California | 2006 | 3 | 97 | PHI |
| 47 | Shelley Duncan | LF | MLB | 6-5 | 215 | Right | Right | 9/29/1979 | 31 | Tucson,Arizona | 2001 | 2 | 62 | NYY |
| 37 | Chad Durbin | P | MLB | 6-1 | 175 | Right | Right | 12/3/1977 | 33 | Spring Valley,Illinois | 1996 | 3 | 79 | KC |
| 8 | Adam Everett | 3B | MLB | 6-0 | 156 | Right | Right | 2/2/1977 | 34 | Austell,Georgia | 1998 | 1 | 12 | BOS |
| 1 | Kosuke Fukudome | 1B | MLB | 6-1 | 185 | Left | Right | 4/26/1977 | 34 | Kagoshima,Japan | | UDFA | | |
| 39 | Justin Germano | P | MLB | 6-2 | 190 | Right | Right | 8/6/1982 | 28 | Pasadena,California | 2000 | 13 | 379 | SD |
| 58 | Jeanmar Gomez | P | MLB | 6-3 | 168 | Right | Right | 10/2/1988 | 22 | Caracas,Venezuela | 2006 | UDFA | | CLE |
| 48 | Travis Hafner | DH | MLB | 6-3 | 215 | Left | Right | 6/3/1977 | 34 | Jamestown,North Dakota | 1996 | 31 | 923 | TEX |
| 50 | Nick Hagadone | P | MLB | 6-5 | 230 | Left | Left | 1/1/1986 | 25 | Sandpoint,Idaho | 2007 | 1 | 55 | BOS |
| 9 | Jack Hannahan | 3B | MLB | 6-2 | 200 | Left | Right | 3/4/1980 | 31 | St. Paul,Minnesota | 2001 | 3 | 87 | DET |
| 32 | Jerad Head | LF | MLB | 6-1 | 195 | Right | Right | 11/15/1982 | 28 | Topeka,Kansas | 2006 | UDFA | | CLE |
| 55 | Roberto Hernandez | P | MLB | 6-4 | 180 | Right | Right | 8/30/1980 | 30 | Santo Domingo,Dominican Republic | 2000 | UDFA | | CLE |
| 56 | Frank Herrmann | P | MLB | 6-4 | 220 | Left | Right | 5/30/1984 | 27 | Rutherford,New Jersey | 2006 | UDFA | | CLE |
| 31 | David Huff | P | MLB | 6-2 | 185 | Both | Left | 8/22/1984 | 26 | San Diego,California | 2006 | 1 | 39 | CLE |
| 30 | Ubaldo Jimenez | P | MLB | 6-2 | 160 | Right | Right | 1/22/1984 | 27 | Nagua,Dominican Republic | 2001 | UDFA | | COL |
| 45 | Josh Judy | P | MLB | 6-4 | 195 | Right | Right | 2/9/1986 | 25 | Morgantown,West Virginia | 2007 | 34 | 1034 | CLE |
| 26 | Austin Kearns | LF-RF | MLB | 6-3 | 220 | Right | Right | 5/20/1980 | 31 | Lexington,Kentucky | 1998 | 1 | 7 | CIN |
| 22 | Jason Kipnis | 2B | MLB | 5-10 | 175 | Left | Right | 4/3/1987 | 24 | Northbrook,Illinois | 2009 | 2 | 63 | CLE |
| 34 | Corey Kluber | P | MLB | 6-4 | 215 | Right | Right | 4/10/1986 | 25 | Birmingham,Alabama | 2007 | 4 | 134 | SD |
| 7 | Matt LaPorta | 1B | MLB | 6-2 | 212 | Right | Right | 1/8/1985 | 26 | Port Charlotte,Florida | 2007 | 1 | 7 | MIL |
| 6 | Louis Marson | C | MLB | 6-1 | 195 | Right | Right | 6/26/1986 | 25 | Scottsdale,Arizona | 2004 | 4 | 122 | PHI |
| 63 | Justin Masterson | P | MLB | 6-6 | 235 | Right | Right | 3/22/1985 | 26 | Beavercreek,Ohio | 2006 | 2 | 71 | BOS |
| 57 | Zach McAllister | P | MLB | 6-5 | 230 | Right | Right | 12/8/1987 | 23 | Chillicothe,Illinois | 2006 | 3 | 104 | NYY |
| 54 | Chris Perez | P | MLB | 6-4 | 225 | Right | Right | 7/1/1985 | 25 | Bradenton,Florida | 2006 | 1 | 42 | STL |
| 53 | Rafael Perez | P | MLB | 6-3 | 170 | Left | Left | 5/15/1982 | 29 | Santo Domingo,Dominican Republic | 2002 | UDFA | | CLE |
| 52 | Vinnie Pestano | P | MLB | 6-1 | 205 | Right | Right | 2/20/1985 | 26 | Newport Beach,California | 2006 | 20 | 611 | CLE |
| 35 | Cord Phelps | 2B | MLB | 6-2 | 200 | Both | Right | 1/23/1987 | 24 | Palo Alto,California | 2008 | 3 | 107 | CLE |
| 44 | Zach Putnam | P | MLB | 6-2 | 215 | Right | Right | 7/3/1987 | 23 | Rochester,Michigan | 2008 | 5 | 171 | CLE |
| 41 | Carlos Santana | C | MLB | 5-11 | 170 | Both | Right | 4/8/1986 | 25 | Santo Domingo,Dominican Republic | 2005 | UDFA | | LAD |
| 46 | Tony Sipp | P | MLB | 6-0 | 185 | Left | Left | 7/12/1983 | 27 | Pascagoula,Mississippi | 2004 | 45 | 1333 | CLE |
| 24 | Grady Sizemore | CF | MLB | 6-2 | 205 | Left | Left | 8/2/1982 | 28 | Seattle,Washington | 2000 | 3 | 75 | MTL |
| 38 | Joe Smith | P | MLB | 6-2 | 205 | Right | Right | 3/22/1984 | 27 | Cincinnati,Ohio | 2006 | 3 | 94 | NYM |
| 51 | Mitch Talbot | P | MLB | 6-2 | 175 | Right | Right | 10/17/1983 | 27 | Cedar City,Utah | 2002 | 2 | 70 | HOU |
| 25 | Jim Thome | DH | MLB | 6-4 | 220 | Left | Right | 8/27/1970 | 40 | Peoria,Illinois | 1989 | 13 | 331 | CLE |
| 43 | Josh Tomlin | P | MLB | 6-1 | 175 | Right | Right | 10/19/1984 | 26 | Tyler,Texas | 2006 | 19 | 581 | CLE |
| 1,2 | Luis Valbuena | 3B-SS | MLB | 5-10 | 160 | Left | Right | 11/30/1985 | 25 | Caja Seca Zulia,Venezuela | 2005 | UDFA | | SEA |
| 32 | Alex White | P | MLB | 6-3 | 185 | Right | Right | 8/29/1988 | 22 | Greenville,North Carolina | 2009 | 1 | 15 | CLE |