| Central | W | L | Pct | GB |
| Detroit | 95 | 67 | .586 | -- |
| Cleveland | 80 | 82 | .494 | 15.0 |
| Chi White Sox | 79 | 83 | .488 | 16.0 |
| KC Royals | 71 | 91 | .438 | 24.0 |
| Minnesota | 63 | 99 | .389 | 32.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2011-04-01 | Mark Buehrle | L | 32 | W 15-10 | @ CLE | 1 | 335 | W | 6.0 | 8 | 4 | 4 | 0 | 1 | 0 | 80 | 27 | 53 | 66% | 1-0 | 6.00 | 1.50 |
| 2011-04-02 | Edwin Jackson | R | 28 | W 8-3 | @ CLE | 1 | 143 | W | 6.0 | 5 | 3 | 2 | 1 | 4 | 7 | 100 | 42 | 58 | 58% | 1-0 | 3.00 | 1.50 |
| 2011-04-03 | John Danks | L | 26 | L 1-7 | @ CLE | 1 | 124 | L | 6.0 | 6 | 2 | 2 | 1 | 1 | 8 | 103 | 38 | 65 | 63% | 0-1 | 3.00 | 1.17 |
| 2011-04-05 | Gavin Floyd | R | 28 | L 6-7 | @ KCA | 1 | 123 | - | 7.0 | 7 | 4 | 4 | 1 | 2 | 5 | 106 | 42 | 64 | 60% | 0-0 | 5.14 | 1.29 |
| 2011-04-06 | Mark Buehrle | L | 32 | W 10-7 | @ KCA | 2 | 336 | - | 5.0 | 8 | 5 | 5 | 0 | 2 | 2 | 85 | 34 | 51 | 60% | 1-0 | 7.36 | 1.73 |
| 2011-04-07 | Edwin Jackson | R | 28 | L 5-1 | vs TBA | 2 | 144 | W | 8.0 | 4 | 1 | 1 | 0 | 1 | 13 | 119 | 41 | 78 | 66% | 2-0 | 1.93 | 1.00 |
| 2011-04-08 | John Danks | L | 26 | W 7-9 | vs TBA | 2 | 125 | - | 6.0 | 6 | 4 | 4 | 1 | 4 | 5 | 104 | 38 | 66 | 63% | 0-1 | 4.50 | 1.42 |
| 2011-04-09 | Philip Humber | R | 28 | L 4-2 | vs TBA | 1 | 3 | W | 6.0 | 4 | 1 | 1 | 0 | 2 | 4 | 85 | 27 | 58 | 68% | 1-0 | 3.38 | 1.25 |
| 2011-04-10 | Gavin Floyd | R | 28 | L 6-1 | vs TBA | 2 | 124 | W | 8.0 | 4 | 1 | 0 | 0 | 1 | 8 | 94 | 32 | 62 | 66% | 1-0 | 2.40 | 0.93 |
| 2011-04-11 | Mark Buehrle | L | 32 | W 1-2 | vs OAK | 3 | 337 | - | 8.0 | 2 | 0 | 0 | 0 | 1 | 1 | 99 | 34 | 65 | 66% | 1-0 | 4.26 | 1.16 |
| 2011-04-12 | Edwin Jackson | R | 28 | L 6-5 | vs OAK | 3 | 145 | - | 4.2 | 7 | 3 | 3 | 0 | 2 | 4 | 99 | 39 | 60 | 61% | 2-0 | 2.84 | 1.21 |
| 2011-04-13 | John Danks | L | 26 | W 4-7 | vs OAK | 3 | 126 | - | 8.0 | 5 | 1 | 1 | 1 | 3 | 7 | 109 | 37 | 72 | 66% | 0-1 | 3.15 | 1.25 |
| 2011-04-15 | Philip Humber | R | 28 | W 3-4 | vs ANA | 2 | 4 | L | 5.0 | 6 | 4 | 2 | 0 | 1 | 4 | 93 | 37 | 56 | 60% | 1-1 | 3.46 | 1.31 |
| 2011-04-16 | Gavin Floyd | R | 28 | W 2-7 | vs ANA | 3 | 125 | L | 6.0 | 8 | 6 | 6 | 2 | 2 | 3 | 97 | 38 | 59 | 61% | 1-1 | 4.29 | 1.14 |
| 2011-04-17 | Mark Buehrle | L | 32 | W 2-4 | vs ANA | 4 | 338 | L | 7.0 | 10 | 4 | 4 | 1 | 2 | 5 | 99 | 40 | 59 | 60% | 1-1 | 4.50 | 1.31 |
| 2011-04-18 | Edwin Jackson | R | 28 | L 0-5 | @ TBA | 4 | 146 | L | 7.0 | 11 | 4 | 4 | 1 | 1 | 3 | 103 | 40 | 63 | 61% | 2-1 | 3.46 | 1.35 |
| 2011-04-19 | John Danks | L | 26 | L 1-2 | @ TBA | 4 | 127 | L | 7.0 | 7 | 2 | 2 | 0 | 0 | 5 | 105 | 32 | 73 | 70% | 0-2 | 3.00 | 1.19 |
| 2011-04-20 | Philip Humber | R | 28 | L 1-4 | @ TBA | 3 | 5 | L | 5.1 | 6 | 4 | 4 | 1 | 1 | 3 | 94 | 36 | 58 | 62% | 1-2 | 4.50 | 1.33 |
| 2011-04-21 | Gavin Floyd | R | 28 | W 9-2 | @ TBA | 4 | 126 | W | 6.0 | 7 | 2 | 2 | 0 | 2 | 7 | 109 | 43 | 66 | 61% | 2-1 | 4.00 | 1.22 |
| 2011-04-22 | Mark Buehrle | L | 32 | L 3-9 | @ DET | 5 | 339 | L | 5.2 | 8 | 6 | 6 | 1 | 2 | 5 | 100 | 43 | 57 | 57% | 1-2 | 5.34 | 1.38 |
| 2011-04-23 | Edwin Jackson | R | 28 | L 0-9 | @ DET | 5 | 147 | L | 5.2 | 12 | 8 | 7 | 0 | 4 | 3 | 110 | 46 | 64 | 58% | 2-2 | 4.94 | 1.65 |
| 2011-04-24 | John Danks | L | 26 | L 0-3 | @ DET | 5 | 128 | L | 6.0 | 9 | 3 | 3 | 0 | 2 | 8 | 114 | 40 | 74 | 65% | 0-3 | 3.27 | 1.30 |
| 2011-04-25 | Philip Humber | R | 28 | W 2-0 | @ NYA | 4 | 6 | W | 7.0 | 1 | 0 | 0 | 0 | 2 | 5 | 101 | 34 | 67 | 66% | 2-2 | 3.24 | 1.08 |
| 2011-04-26 | Gavin Floyd | R | 28 | W 3-2 | @ NYA | 5 | 127 | W | 8.0 | 4 | 2 | 2 | 2 | 1 | 10 | 102 | 36 | 66 | 65% | 3-1 | 3.60 | 1.09 |
| 2011-04-27 | Mark Buehrle | L | 32 | L 1-3 | @ NYA | 6 | 340 | L | 7.0 | 6 | 3 | 3 | 1 | 2 | 5 | 106 | 44 | 62 | 58% | 1-3 | 5.08 | 1.33 |
| 2011-04-28 | Edwin Jackson | R | 28 | L 3-12 | @ NYA | 6 | 148 | L | 4.0 | 4 | 6 | 6 | 1 | 5 | 2 | 95 | 46 | 49 | 52% | 2-3 | 5.91 | 1.71 |
| 2011-04-29 | John Danks | L | 26 | W 4-10 | vs BAL | 6 | 129 | L | 6.0 | 8 | 5 | 5 | 2 | 1 | 3 | 107 | 35 | 72 | 67% | 0-4 | 3.92 | 1.33 |
| 2011-04-30 | Philip Humber | R | 28 | W 2-6 | vs BAL | 5 | 7 | L | 7.0 | 3 | 2 | 2 | 1 | 1 | 5 | 96 | 36 | 60 | 63% | 2-3 | 3.09 | 0.97 |
| 2011-05-01 | Gavin Floyd | R | 28 | W 4-6 | vs BAL | 6 | 128 | L | 6.0 | 7 | 6 | 6 | 2 | 2 | 5 | 98 | 39 | 59 | 60% | 3-2 | 4.39 | 1.15 |
| 2011-05-02 | Mark Buehrle | L | 32 | L 6-2 | vs BAL | 7 | 341 | W | 6.2 | 8 | 0 | 0 | 0 | 4 | 4 | 103 | 45 | 58 | 56% | 2-3 | 4.40 | 1.42 |
| 2011-05-03 | Edwin Jackson | R | 28 | W 0-1 | vs MIN | 7 | 149 | L | 8.0 | 6 | 1 | 1 | 1 | 1 | 2 | 106 | 38 | 68 | 64% | 2-4 | 5.02 | 1.56 |
| 2011-05-04 | John Danks | L | 26 | W 2-3 | vs MIN | 7 | 130 | L | 8.0 | 8 | 3 | 3 | 0 | 3 | 0 | 103 | 40 | 63 | 61% | 0-5 | 3.83 | 1.34 |
| 2011-05-06 | Philip Humber | R | 28 | L 2-3 | @ SEA | 6 | 8 | - | 7.0 | 3 | 2 | 2 | 0 | 3 | 4 | 93 | 35 | 58 | 62% | 2-3 | 3.00 | 0.95 |
| 2011-05-07 | Gavin Floyd | R | 28 | W 6-0 | @ SEA | 7 | 129 | W | 8.0 | 3 | 0 | 0 | 0 | 2 | 6 | 101 | 39 | 62 | 61% | 4-2 | 3.67 | 1.06 |
| 2011-05-08 | Mark Buehrle | L | 32 | W 5-2 | @ SEA | 8 | 342 | - | 8.0 | 9 | 2 | 2 | 0 | 0 | 3 | 102 | 35 | 67 | 66% | 2-3 | 4.08 | 1.38 |
| 2011-05-09 | Edwin Jackson | R | 28 | W 8-0 | @ ANA | 8 | 150 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 5 | 105 | 43 | 62 | 59% | 3-4 | 4.32 | 1.46 |
| 2011-05-10 | John Danks | L | 26 | L 2-6 | @ ANA | 8 | 131 | L | 5.0 | 10 | 6 | 6 | 1 | 2 | 4 | 95 | 26 | 69 | 73% | 0-6 | 4.50 | 1.44 |
| 2011-05-11 | Jake Peavy | R | 30 | W 6-4 | @ ANA | 1 | 233 | - | 6.0 | 7 | 4 | 4 | 0 | 0 | 4 | 88 | 25 | 63 | 72% | 0-0 | 6.00 | 1.17 |
| 2011-05-13 | Philip Humber | R | 28 | W 4-3 | @ OAK | 7 | 9 | W | 6.0 | 6 | 3 | 3 | 0 | 0 | 1 | 83 | 22 | 61 | 73% | 3-3 | 3.20 | 0.96 |
| 2011-05-14 | Gavin Floyd | R | 28 | L 2-6 | @ OAK | 8 | 130 | L | 4.1 | 9 | 5 | 5 | 0 | 2 | 4 | 99 | 39 | 60 | 61% | 4-3 | 4.25 | 1.19 |
| 2011-05-15 | Mark Buehrle | L | 32 | W 4-3 | @ OAK | 9 | 343 | W | 6.1 | 7 | 3 | 3 | 1 | 3 | 6 | 106 | 45 | 61 | 58% | 3-3 | 4.05 | 1.38 |
| 2011-05-16 | Edwin Jackson | R | 28 | W 0-4 | vs TEX | 9 | 151 | L | 5.1 | 11 | 4 | 4 | 0 | 3 | 6 | 111 | 45 | 66 | 59% | 3-5 | 4.50 | 1.55 |
| 2011-05-17 | John Danks | L | 26 | L 4-3 | vs TEX | 9 | 132 | - | 6.1 | 4 | 3 | 2 | 0 | 6 | 2 | 112 | 48 | 64 | 57% | 0-6 | 4.34 | 1.47 |
| 2011-05-18 | Jake Peavy | R | 30 | L 1-0 | vs CLE | 2 | 234 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 8 | 108 | 33 | 75 | 69% | 1-0 | 2.40 | 0.67 |
| 2011-05-19 | Gavin Floyd | R | 28 | L 8-2 | vs CLE | 9 | 131 | W | 7.0 | 5 | 1 | 1 | 0 | 1 | 3 | 103 | 36 | 67 | 65% | 5-3 | 3.90 | 1.15 |
| 2011-05-20 | Philip Humber | R | 28 | W 4-6 | vs LAN | 8 | 10 | - | 7.0 | 5 | 2 | 2 | 1 | 1 | 4 | 102 | 33 | 69 | 68% | 3-3 | 3.12 | 0.94 |
| 2011-05-21 | Mark Buehrle | L | 32 | L 9-2 | vs LAN | 10 | 344 | W | 7.0 | 7 | 2 | 2 | 1 | 0 | 1 | 96 | 33 | 63 | 66% | 4-3 | 3.90 | 1.34 |
| 2011-05-22 | Edwin Jackson | R | 28 | L 8-3 | vs LAN | 10 | 152 | W | 5.2 | 5 | 1 | 1 | 0 | 2 | 7 | 107 | 39 | 68 | 64% | 4-5 | 4.28 | 1.54 |
| 2011-05-23 | John Danks | L | 26 | L 0-4 | @ TEX | 10 | 133 | L | 8.0 | 9 | 4 | 4 | 2 | 2 | 3 | 105 | 33 | 72 | 69% | 0-7 | 4.36 | 1.45 |
| 2011-05-24 | Jake Peavy | R | 30 | W 8-6 | @ TEX | 3 | 235 | - | 3.0 | 5 | 2 | 2 | 0 | 1 | 2 | 63 | 21 | 42 | 67% | 1-0 | 3.00 | 0.89 |
| 2011-05-25 | Gavin Floyd | R | 28 | L 1-2 | @ TEX | 10 | 132 | L | 7.0 | 3 | 2 | 1 | 0 | 1 | 5 | 113 | 43 | 70 | 62% | 5-4 | 3.63 | 1.09 |
| 2011-05-26 | Philip Humber | R | 28 | W 3-1 | @ TOR | 9 | 11 | - | 7.2 | 6 | 1 | 1 | 1 | 1 | 3 | 115 | 51 | 64 | 56% | 3-3 | 2.85 | 0.93 |
| 2011-05-27 | Mark Buehrle | L | 32 | L 2-4 | @ TOR | 11 | 345 | L | 7.0 | 9 | 3 | 3 | 0 | 2 | 3 | 122 | 45 | 77 | 63% | 4-4 | 3.89 | 1.36 |
| 2011-05-28 | Edwin Jackson | R | 28 | L 8-9 | @ TOR | 11 | 153 | - | 6.2 | 9 | 6 | 6 | 1 | 1 | 7 | 100 | 31 | 69 | 69% | 4-5 | 4.63 | 1.53 |
| 2011-05-29 | John Danks | L | 26 | L 4-13 | @ TOR | 11 | 134 | L | 4.0 | 9 | 9 | 9 | 3 | 1 | 1 | 96 | 36 | 60 | 63% | 0-8 | 5.27 | 1.51 |
| 2011-05-30 | Jake Peavy | R | 30 | W 7-3 | @ BOS | 4 | 236 | W | 7.0 | 6 | 3 | 3 | 1 | 0 | 2 | 112 | 34 | 78 | 70% | 2-0 | 3.24 | 0.88 |
| 2011-05-31 | Philip Humber | R | 28 | W 10-7 | @ BOS | 10 | 12 | W | 7.2 | 9 | 4 | 4 | 1 | 1 | 5 | 97 | 28 | 69 | 71% | 4-3 | 3.04 | 0.97 |
| 2011-06-01 | Gavin Floyd | R | 28 | W 7-4 | @ BOS | 11 | 133 | W | 6.2 | 9 | 4 | 4 | 1 | 1 | 1 | 97 | 33 | 64 | 66% | 6-5 | 3.84 | 1.13 |
| 2011-06-03 | Mark Buehrle | L | 32 | L 6-4 | vs DET | 12 | 346 | W | 6.0 | 10 | 3 | 3 | 1 | 1 | 4 | 97 | 36 | 61 | 63% | 5-4 | 3.94 | 1.40 |
| 2011-06-04 | Edwin Jackson | R | 28 | W 2-4 | vs DET | 12 | 154 | - | 6.0 | 7 | 2 | 2 | 1 | 4 | 5 | 124 | 43 | 81 | 65% | 4-5 | 4.50 | 1.55 |
| 2011-06-05 | Jake Peavy | R | 30 | W 3-7 | vs DET | 5 | 237 | L | 4.0 | 3 | 6 | 6 | 1 | 3 | 4 | 74 | 30 | 44 | 59% | 2-1 | 4.66 | 0.97 |
| 2011-06-06 | John Danks | L | 26 | L 3-1 | vs SEA | 12 | 135 | W | 7.1 | 7 | 1 | 0 | 0 | 1 | 6 | 98 | 33 | 65 | 66% | 1-8 | 4.73 | 1.46 |
| 2011-06-07 | Philip Humber | R | 28 | L 5-1 | vs SEA | 11 | 13 | W | 7.2 | 5 | 1 | 1 | 0 | 3 | 5 | 106 | 37 | 69 | 65% | 5-3 | 2.88 | 0.99 |
| 2011-06-08 | Gavin Floyd | R | 28 | W 4-7 | vs SEA | 12 | 134 | - | 6.0 | 5 | 3 | 3 | 0 | 3 | 3 | 109 | 42 | 67 | 61% | 6-5 | 3.89 | 1.15 |
| 2011-06-09 | Mark Buehrle | L | 32 | L 9-4 | vs OAK | 13 | 347 | W | 7.0 | 7 | 3 | 3 | 1 | 1 | 4 | 102 | 37 | 65 | 64% | 6-4 | 3.93 | 1.38 |
| 2011-06-10 | Edwin Jackson | R | 28 | W 5-7 | vs OAK | 13 | 155 | - | 6.0 | 8 | 2 | 2 | 0 | 1 | 1 | 99 | 37 | 62 | 63% | 4-5 | 4.39 | 1.55 |
| 2011-06-11 | John Danks | L | 26 | L 3-2 | vs OAK | 13 | 136 | W | 7.2 | 4 | 2 | 2 | 0 | 2 | 4 | 107 | 39 | 68 | 64% | 2-8 | 4.55 | 1.41 |
| 2011-06-12 | Philip Humber | R | 28 | L 5-4 | vs OAK | 12 | 14 | W | 7.0 | 4 | 3 | 3 | 1 | 2 | 7 | 103 | 39 | 64 | 62% | 6-3 | 2.96 | 0.98 |
| 2011-06-15 | Gavin Floyd | R | 28 | L 1-4 | @ MIN | 13 | 135 | L | 8.0 | 11 | 4 | 4 | 0 | 2 | 6 | 127 | 43 | 84 | 66% | 6-6 | 3.94 | 1.19 |
| 2011-06-16 | Mark Buehrle | L | 32 | L 0-1 | @ MIN | 14 | 348 | L | 7.0 | 3 | 1 | 1 | 1 | 2 | 3 | 98 | 38 | 60 | 61% | 6-5 | 3.73 | 1.33 |
| 2011-06-17 | Edwin Jackson | R | 28 | L 1-4 | @ ARI | 14 | 156 | L | 6.2 | 8 | 4 | 4 | 0 | 0 | 8 | 112 | 40 | 72 | 64% | 4-6 | 4.45 | 1.52 |
| 2011-06-18 | John Danks | L | 26 | W 6-2 | @ ARI | 14 | 137 | W | 7.0 | 7 | 2 | 1 | 0 | 0 | 7 | 115 | 40 | 75 | 65% | 3-8 | 4.30 | 1.38 |
| 2011-06-19 | Philip Humber | R | 28 | W 8-2 | @ ARI | 13 | 15 | W | 7.2 | 7 | 2 | 2 | 0 | 1 | 5 | 110 | 38 | 72 | 65% | 7-3 | 2.90 | 0.98 |
| 2011-06-20 | Gavin Floyd | R | 28 | W 3-6 | vs CHN | 14 | 136 | L | 5.0 | 5 | 6 | 6 | 2 | 3 | 3 | 101 | 39 | 62 | 61% | 6-7 | 4.31 | 1.21 |
| 2011-06-21 | Mark Buehrle | L | 32 | L 3-2 | vs CHN | 15 | 349 | - | 5.1 | 5 | 2 | 2 | 1 | 0 | 3 | 70 | 19 | 51 | 73% | 6-5 | 3.73 | 1.31 |
| 2011-06-22 | Jake Peavy | R | 30 | L 4-3 | vs CHN | 6 | 238 | W | 5.1 | 7 | 3 | 3 | 1 | 3 | 5 | 102 | 35 | 67 | 66% | 3-1 | 4.76 | 1.12 |
| 2011-06-24 | Edwin Jackson | R | 28 | W 5-9 | vs WAS | 15 | 157 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 8 | 106 | 43 | 63 | 59% | 4-6 | 4.12 | 1.48 |
| 2011-06-25 | John Danks | L | 26 | L 3-0 | vs WAS | 15 | 138 | - | 1.2 | 0 | 0 | 0 | 0 | 0 | 2 | 26 | 10 | 16 | 62% | 3-8 | 4.21 | 1.35 |
| 2011-06-26 | Philip Humber | R | 29 | W 1-2 | vs WAS | 14 | 16 | L | 6.2 | 3 | 2 | 2 | 1 | 3 | 4 | 109 | 42 | 67 | 61% | 7-4 | 2.88 | 0.97 |
| 2011-06-28 | Gavin Floyd | R | 28 | L 2-3 | @ COL | 15 | 137 | - | 7.0 | 6 | 2 | 2 | 0 | 2 | 0 | 94 | 33 | 61 | 65% | 6-7 | 4.19 | 1.21 |
| 2011-06-29 | Mark Buehrle | L | 32 | W 3-2 | @ COL | 16 | 350 | - | 7.0 | 7 | 2 | 2 | 2 | 2 | 4 | 101 | 40 | 61 | 60% | 6-5 | 3.65 | 1.31 |
| 2011-06-30 | Jake Peavy | R | 30 | W 6-4 | @ COL | 7 | 239 | - | 6.0 | 7 | 4 | 4 | 1 | 2 | 4 | 104 | 35 | 69 | 66% | 4-1 | 4.50 | 1.09 |
| 2011-07-01 | Edwin Jackson | R | 28 | W 6-4 | @ CHN | 16 | 158 | W | 6.0 | 5 | 4 | 4 | 1 | 1 | 5 | 93 | 31 | 62 | 67% | 5-6 | 4.23 | 1.45 |
| 2011-07-02 | Philip Humber | R | 29 | W 1-0 | @ CHN | 15 | 17 | W | 7.0 | 5 | 0 | 0 | 0 | 3 | 4 | 116 | 49 | 67 | 58% | 8-4 | 2.68 | 0.98 |
| 2011-07-03 | Gavin Floyd | R | 28 | L 1-3 | @ CHN | 16 | 138 | L | 7.0 | 7 | 3 | 3 | 1 | 1 | 8 | 92 | 27 | 65 | 71% | 6-8 | 4.17 | 1.20 |
| 2011-07-04 | Mark Buehrle | L | 32 | L 5-4 | vs KCA | 17 | 351 | - | 7.0 | 7 | 3 | 3 | 1 | 1 | 4 | 101 | 34 | 67 | 66% | 6-5 | 3.66 | 1.30 |
| 2011-07-05 | Jake Peavy | R | 30 | W 3-5 | vs KCA | 8 | 240 | L | 6.0 | 6 | 5 | 5 | 0 | 2 | 4 | 103 | 33 | 70 | 68% | 4-2 | 4.86 | 1.12 |
| 2011-07-06 | Edwin Jackson | R | 28 | W 1-4 | vs KCA | 17 | 159 | L | 7.0 | 8 | 4 | 4 | 1 | 1 | 6 | 120 | 40 | 80 | 67% | 5-7 | 4.29 | 1.44 |
| 2011-07-07 | Philip Humber | R | 29 | W 2-6 | vs MIN | 16 | 18 | L | 3.2 | 11 | 6 | 6 | 0 | 1 | 2 | 84 | 27 | 57 | 68% | 8-5 | 3.11 | 1.07 |
| 2011-07-08 | Gavin Floyd | R | 28 | W 5-8 | vs MIN | 17 | 139 | L | 3.2 | 9 | 7 | 7 | 0 | 2 | 3 | 93 | 39 | 54 | 58% | 6-9 | 4.58 | 1.26 |
| 2011-07-09 | Mark Buehrle | L | 32 | L 4-3 | vs MIN | 18 | 352 | - | 8.0 | 4 | 3 | 0 | 0 | 1 | 8 | 118 | 42 | 76 | 64% | 6-5 | 3.42 | 1.26 |
| 2011-07-10 | Jake Peavy | R | 30 | W 3-6 | vs MIN | 9 | 241 | L | 4.1 | 10 | 5 | 5 | 0 | 2 | 2 | 89 | 30 | 59 | 66% | 4-3 | 5.24 | 1.24 |
| 2011-07-15 | Gavin Floyd | R | 28 | W 8-2 | @ DET | 18 | 140 | W | 7.2 | 6 | 2 | 1 | 1 | 1 | 5 | 97 | 32 | 65 | 67% | 7-9 | 4.39 | 1.24 |
| 2011-07-16 | Edwin Jackson | R | 28 | W 5-0 | @ DET | 18 | 160 | W | 9.0 | 9 | 0 | 0 | 0 | 2 | 2 | 100 | 31 | 69 | 69% | 6-7 | 3.96 | 1.42 |
| 2011-07-17 | Philip Humber | R | 29 | L 3-4 | @ DET | 17 | 19 | L | 5.2 | 7 | 4 | 4 | 1 | 1 | 8 | 88 | 34 | 54 | 61% | 8-6 | 3.27 | 1.08 |
| 2011-07-18 | Mark Buehrle | L | 32 | W 5-2 | @ KCA | 19 | 353 | W | 7.0 | 5 | 2 | 2 | 0 | 1 | 3 | 111 | 35 | 76 | 68% | 7-5 | 3.38 | 1.23 |
| 2011-07-19 | Jake Peavy | R | 30 | L 2-4 | @ KCA | 10 | 242 | L | 6.0 | 7 | 3 | 3 | 0 | 1 | 5 | 96 | 26 | 70 | 73% | 4-4 | 5.16 | 1.25 |
| 2011-07-20 | John Danks | L | 26 | L 1-2 | @ KCA | 16 | 139 | - | 7.0 | 5 | 0 | 0 | 0 | 1 | 6 | 111 | 37 | 74 | 67% | 3-8 | 3.92 | 1.32 |
| 2011-07-22 | Gavin Floyd | R | 28 | W 3-0 | @ CLE | 19 | 141 | W | 7.2 | 4 | 0 | 0 | 0 | 0 | 5 | 97 | 35 | 62 | 64% | 8-9 | 4.11 | 1.20 |
| 2011-07-24 | Edwin Jackson | R | 28 | W 4-2 | @ CLE | 19 | 161 | W | 6.0 | 5 | 2 | 2 | 0 | 3 | 3 | 107 | 47 | 60 | 56% | 7-7 | 3.91 | 1.42 |
| 2011-07-25 | Mark Buehrle | L | 32 | L 6-3 | vs DET | 20 | 354 | W | 6.0 | 10 | 2 | 0 | 0 | 1 | 4 | 109 | 41 | 68 | 62% | 8-5 | 3.22 | 1.26 |
| 2011-07-26 | Jake Peavy | R | 30 | W 4-5 | vs DET | 11 | 243 | - | 6.0 | 10 | 4 | 4 | 0 | 1 | 6 | 110 | 37 | 73 | 66% | 4-4 | 5.24 | 1.30 |
| 2011-07-27 | John Danks | L | 26 | L 2-1 | vs DET | 17 | 140 | W | 6.0 | 6 | 1 | 1 | 1 | 3 | 10 | 115 | 41 | 74 | 64% | 4-8 | 3.79 | 1.33 |
| 2011-07-29 | Gavin Floyd | R | 29 | L 3-1 | vs BOS | 20 | 142 | W | 7.0 | 3 | 1 | 1 | 1 | 2 | 6 | 105 | 39 | 66 | 63% | 9-9 | 3.96 | 1.17 |
| 2011-07-30 | Philip Humber | R | 29 | W 2-10 | vs BOS | 18 | 20 | L | 4.2 | 6 | 4 | 4 | 0 | 2 | 4 | 84 | 34 | 50 | 60% | 8-7 | 3.43 | 1.10 |
| 2011-07-31 | Mark Buehrle | L | 32 | W 3-5 | vs BOS | 21 | 355 | - | 6.0 | 5 | 2 | 2 | 1 | 3 | 2 | 105 | 42 | 63 | 60% | 8-5 | 3.21 | 1.26 |
| 2011-08-01 | Jake Peavy | R | 30 | W 2-3 | vs NYA | 12 | 244 | L | 7.0 | 8 | 3 | 3 | 0 | 1 | 4 | 113 | 40 | 73 | 65% | 4-5 | 5.11 | 1.30 |
| 2011-08-02 | John Danks | L | 26 | W 0-6 | vs NYA | 18 | 141 | L | 6.0 | 9 | 4 | 4 | 2 | 1 | 5 | 112 | 35 | 77 | 69% | 4-9 | 3.90 | 1.35 |
| 2011-08-03 | Gavin Floyd | R | 29 | W 7-18 | vs NYA | 21 | 143 | L | 2.1 | 9 | 10 | 10 | 2 | 1 | 2 | 54 | 19 | 35 | 65% | 9-10 | 4.57 | 1.23 |
| 2011-08-04 | Philip Humber | R | 29 | W 2-7 | vs NYA | 19 | 21 | L | 6.1 | 5 | 4 | 4 | 1 | 2 | 3 | 92 | 31 | 61 | 66% | 8-8 | 3.56 | 1.10 |
| 2011-08-05 | Mark Buehrle | L | 32 | W 5-3 | @ MIN | 22 | 356 | W | 8.0 | 4 | 3 | 0 | 1 | 0 | 3 | 94 | 31 | 63 | 67% | 9-5 | 3.04 | 1.22 |
| 2011-08-06 | Zach Stewart | R | 25 | W 6-1 | @ MIN | 4 | 4 | W | 6.1 | 8 | 1 | 1 | 0 | 1 | 2 | 84 | 27 | 57 | 68% | 1-1 | 3.91 | 1.74 |
| 2011-08-07 | Jake Peavy | R | 30 | W 7-0 | @ MIN | 13 | 245 | W | 8.0 | 3 | 0 | 0 | 0 | 0 | 6 | 110 | 38 | 72 | 65% | 5-5 | 4.61 | 1.21 |
| 2011-08-08 | John Danks | L | 26 | W 7-6 | @ BAL | 19 | 142 | - | 6.1 | 7 | 5 | 4 | 0 | 0 | 7 | 86 | 29 | 57 | 66% | 4-9 | 4.01 | 1.34 |
| 2011-08-09 | Gavin Floyd | R | 29 | W 4-3 | @ BAL | 22 | 144 | W | 6.2 | 7 | 3 | 3 | 0 | 1 | 4 | 88 | 26 | 62 | 70% | 10-10 | 4.53 | 1.22 |
| 2011-08-10 | Philip Humber | R | 29 | L 4-6 | @ BAL | 20 | 22 | - | 6.0 | 11 | 4 | 4 | 2 | 1 | 3 | 95 | 29 | 66 | 69% | 8-8 | 3.67 | 1.15 |
| 2011-08-11 | Mark Buehrle | L | 32 | W 6-3 | @ BAL | 23 | 357 | W | 8.0 | 6 | 3 | 3 | 1 | 0 | 6 | 103 | 33 | 70 | 68% | 10-5 | 3.06 | 1.20 |
| 2011-08-12 | Zach Stewart | R | 25 | W 1-5 | vs KCA | 5 | 5 | L | 6.1 | 7 | 2 | 2 | 1 | 2 | 3 | 88 | 28 | 60 | 68% | 1-2 | 3.72 | 1.69 |
| 2011-08-13 | Jake Peavy | R | 30 | L 5-4 | vs KCA | 14 | 246 | - | 6.2 | 9 | 4 | 4 | 0 | 1 | 6 | 109 | 39 | 70 | 64% | 5-5 | 4.70 | 1.24 |
| 2011-08-14 | John Danks | L | 26 | L 6-2 | vs KCA | 20 | 143 | W | 6.0 | 4 | 2 | 2 | 0 | 4 | 6 | 105 | 39 | 66 | 63% | 5-9 | 3.96 | 1.34 |
| 2011-08-16 | Gavin Floyd | R | 29 | L 8-7 | vs CLE | 23 | 145 | - | 5.2 | 5 | 5 | 5 | 0 | 1 | 9 | 90 | 32 | 58 | 64% | 10-10 | 4.65 | 1.21 |
| 2011-08-17 | Mark Buehrle | L | 32 | W 1-4 | vs CLE | 24 | 358 | L | 7.1 | 12 | 4 | 4 | 0 | 2 | 3 | 113 | 37 | 76 | 67% | 10-6 | 3.15 | 1.23 |
| 2011-08-18 | Philip Humber | R | 29 | W 2-4 | vs CLE | 21 | 23 | - | 1.1 | 3 | 0 | 0 | 0 | 0 | 3 | 26 | 9 | 17 | 65% | 8-8 | 3.64 | 1.16 |
| 2011-08-19 | Jake Peavy | R | 30 | W 4-7 | vs TEX | 15 | 247 | L | 6.0 | 6 | 7 | 7 | 3 | 2 | 5 | 99 | 33 | 66 | 67% | 5-6 | 5.07 | 1.24 |
| 2011-08-20 | John Danks | L | 26 | L 3-2 | vs TEX | 21 | 144 | - | 7.0 | 7 | 2 | 2 | 2 | 0 | 5 | 106 | 26 | 80 | 75% | 5-9 | 3.89 | 1.32 |
| 2011-08-21 | Gavin Floyd | R | 29 | L 10-0 | vs TEX | 24 | 146 | W | 7.0 | 3 | 0 | 0 | 0 | 1 | 6 | 116 | 43 | 73 | 63% | 11-10 | 4.44 | 1.19 |
| 2011-08-23 | Mark Buehrle | L | 32 | L 4-5 | @ ANA | 25 | 359 | - | 6.0 | 7 | 4 | 3 | 1 | 1 | 2 | 113 | 41 | 72 | 64% | 10-6 | 3.20 | 1.24 |
| 2011-08-24 | Zach Stewart | R | 25 | L 0-8 | @ ANA | 6 | 6 | L | 6.0 | 7 | 7 | 7 | 1 | 2 | 4 | 105 | 45 | 60 | 57% | 1-3 | 4.73 | 1.60 |
| 2011-08-26 | Jake Peavy | R | 30 | W 4-2 | @ SEA | 16 | 248 | W | 6.0 | 7 | 2 | 2 | 1 | 3 | 8 | 110 | 37 | 73 | 66% | 6-6 | 4.95 | 1.27 |
| 2011-08-27 | John Danks | L | 26 | W 3-0 | @ SEA | 22 | 145 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 10 | 120 | 39 | 81 | 68% | 6-9 | 3.64 | 1.26 |
| 2011-08-28 | Gavin Floyd | R | 29 | W 9-3 | @ SEA | 25 | 147 | W | 7.1 | 5 | 2 | 2 | 1 | 0 | 6 | 110 | 39 | 71 | 65% | 12-10 | 4.36 | 1.17 |
| 2011-08-29 | Mark Buehrle | L | 32 | L 3-0 | vs MIN | 26 | 360 | W | 7.2 | 4 | 0 | 0 | 0 | 2 | 4 | 107 | 36 | 71 | 66% | 11-6 | 3.05 | 1.21 |
| 2011-08-30 | Zach Stewart | R | 25 | L 8-6 | vs MIN | 7 | 7 | - | 4.2 | 7 | 6 | 6 | 1 | 2 | 3 | 82 | 28 | 54 | 66% | 1-3 | 5.52 | 1.66 |
| 2011-08-31 | Jake Peavy | R | 30 | W 6-7 | vs MIN | 17 | 249 | L | 5.0 | 8 | 6 | 6 | 2 | 0 | 4 | 88 | 33 | 55 | 63% | 6-7 | 5.23 | 1.29 |
| 2011-09-02 | John Danks | L | 26 | L 1-8 | @ DET | 23 | 146 | L | 4.2 | 9 | 8 | 8 | 1 | 2 | 4 | 92 | 30 | 62 | 67% | 6-10 | 4.01 | 1.29 |
| 2011-09-03 | Gavin Floyd | R | 29 | L 8-9 | @ DET | 26 | 148 | - | 5.0 | 8 | 4 | 4 | 1 | 0 | 4 | 85 | 33 | 52 | 61% | 12-10 | 4.45 | 1.18 |
| 2011-09-04 | Mark Buehrle | L | 32 | L 2-18 | @ DET | 27 | 361 | L | 3.1 | 10 | 8 | 7 | 0 | 2 | 4 | 87 | 34 | 53 | 61% | 11-7 | 3.35 | 1.26 |
| 2011-09-05 | Philip Humber | R | 29 | W 2-1 | @ MIN | 22 | 24 | W | 7.0 | 6 | 0 | 0 | 0 | 0 | 6 | 100 | 29 | 71 | 71% | 9-8 | 3.46 | 1.14 |
| 2011-09-05 | Zach Stewart | R | 25 | W 4-0 | @ MIN | 8 | 8 | W | 9.0 | 1 | 0 | 0 | 0 | 0 | 9 | 112 | 39 | 73 | 65% | 2-3 | 4.58 | 1.40 |
| 2011-09-06 | Jake Peavy | R | 30 | W 3-0 | @ MIN | 18 | 250 | W | 6.1 | 4 | 0 | 0 | 0 | 2 | 9 | 112 | 34 | 78 | 70% | 7-7 | 4.90 | 1.26 |
| 2011-09-07 | John Danks | L | 26 | L 4-5 | @ MIN | 24 | 147 | L | 6.0 | 6 | 5 | 4 | 0 | 2 | 4 | 118 | 41 | 77 | 65% | 6-11 | 4.09 | 1.30 |
| 2011-09-08 | Gavin Floyd | R | 29 | L 8-1 | vs CLE | 27 | 149 | - | 5.2 | 5 | 1 | 1 | 0 | 2 | 4 | 112 | 49 | 63 | 56% | 12-10 | 4.34 | 1.18 |
| 2011-09-09 | Mark Buehrle | L | 32 | W 4-8 | vs CLE | 28 | 362 | L | 5.2 | 8 | 7 | 7 | 2 | 2 | 4 | 107 | 39 | 68 | 64% | 11-8 | 3.58 | 1.27 |
| 2011-09-10 | Philip Humber | R | 29 | L 7-3 | vs CLE | 23 | 25 | - | 6.0 | 7 | 2 | 2 | 0 | 0 | 7 | 72 | 20 | 52 | 72% | 9-8 | 3.44 | 1.15 |
| 2011-09-11 | Zach Stewart | R | 25 | W 3-7 | vs CLE | 9 | 9 | L | 5.0 | 7 | 3 | 3 | 0 | 2 | 4 | 93 | 39 | 54 | 58% | 2-4 | 4.66 | 1.43 |
| 2011-09-12 | John Danks | L | 26 | W 4-14 | vs DET | 25 | 148 | L | 5.0 | 11 | 8 | 7 | 2 | 3 | 5 | 95 | 36 | 59 | 62% | 6-12 | 4.36 | 1.34 |
| 2011-09-13 | Gavin Floyd | R | 29 | W 0-5 | vs DET | 28 | 150 | L | 5.1 | 4 | 4 | 4 | 1 | 4 | 3 | 95 | 42 | 53 | 56% | 12-11 | 4.42 | 1.19 |
| 2011-09-14 | Dylan Axelrod | R | 26 | W 5-6 | vs DET | 1 | 1 | - | 6.0 | 6 | 2 | 2 | 1 | 2 | 8 | 91 | 32 | 59 | 65% | 0-0 | 2.25 | 1.38 |
| 2011-09-15 | Mark Buehrle | L | 32 | L 2-7 | @ KCA | 29 | 363 | L | 6.1 | 15 | 7 | 6 | 2 | 2 | 1 | 106 | 40 | 66 | 62% | 11-9 | 3.75 | 1.32 |
| 2011-09-16 | Philip Humber | R | 29 | L 6-7 | @ KCA | 24 | 26 | - | 6.0 | 9 | 6 | 5 | 1 | 2 | 4 | 109 | 44 | 65 | 60% | 9-8 | 3.60 | 1.17 |
| 2011-09-17 | Zach Stewart | R | 25 | L 3-10 | @ KCA | 10 | 10 | L | 5.0 | 11 | 5 | 5 | 1 | 2 | 2 | 104 | 38 | 66 | 63% | 2-5 | 5.00 | 1.52 |
| 2011-09-18 | John Danks | L | 26 | W 10-5 | @ KCA | 26 | 149 | W | 6.0 | 10 | 4 | 3 | 0 | 0 | 0 | 102 | 36 | 66 | 65% | 7-12 | 4.36 | 1.36 |
| 2011-09-20 | Gavin Floyd | R | 29 | L 3-4 | @ CLE | 29 | 151 | L | 6.2 | 7 | 4 | 4 | 3 | 0 | 7 | 98 | 30 | 68 | 69% | 12-12 | 4.45 | 1.18 |
| 2011-09-20 | Dylan Axelrod | R | 26 | W 5-4 | @ CLE | 2 | 2 | - | 4.2 | 7 | 4 | 4 | 0 | 4 | 3 | 101 | 45 | 56 | 55% | 0-0 | 4.15 | 1.69 |
| 2011-09-21 | Mark Buehrle | L | 32 | W 8-4 | @ CLE | 30 | 364 | W | 6.0 | 4 | 2 | 2 | 1 | 2 | 2 | 96 | 37 | 59 | 61% | 12-9 | 3.73 | 1.31 |
| 2011-09-22 | Philip Humber | R | 29 | L 2-11 | @ CLE | 25 | 27 | L | 6.0 | 8 | 7 | 7 | 2 | 2 | 4 | 100 | 36 | 64 | 64% | 9-9 | 3.87 | 1.19 |
| 2011-09-23 | Zach Stewart | R | 25 | W 1-11 | vs KCA | 11 | 11 | L | 4.0 | 12 | 9 | 9 | 4 | 0 | 1 | 68 | 22 | 46 | 68% | 2-6 | 5.91 | 1.61 |
| 2011-09-24 | John Danks | L | 26 | L 6-3 | vs KCA | 27 | 150 | W | 7.1 | 6 | 3 | 3 | 0 | 1 | 8 | 90 | 23 | 67 | 74% | 8-12 | 4.34 | 1.34 |
| 2011-09-25 | Gavin Floyd | R | 29 | W 1-2 | vs KCA | 30 | 152 | L | 8.0 | 3 | 2 | 2 | 0 | 2 | 10 | 118 | 44 | 74 | 63% | 12-13 | 4.36 | 1.16 |
| 2011-09-26 | Dylan Axelrod | R | 26 | L 4-3 | vs TOR | 3 | 3 | W | 6.0 | 3 | 0 | 0 | 0 | 2 | 6 | 84 | 33 | 51 | 61% | 1-0 | 2.84 | 1.42 |
| 2011-09-27 | Mark Buehrle | L | 33 | L 2-1 | vs TOR | 31 | 365 | W | 7.0 | 6 | 0 | 0 | 0 | 0 | 6 | 97 | 32 | 65 | 67% | 13-9 | 3.60 | 1.30 |
| 2011-09-28 | Philip Humber | R | 29 | W 2-3 | vs TOR | 26 | 28 | - | 6.2 | 2 | 1 | 1 | 0 | 4 | 9 | 104 | 43 | 61 | 59% | 9-9 | 3.75 | 1.18 |