| 2011-04-01 | vs PIT | 1 | L 3-6 | 0-1 | 3 | 41,358 | Ryan Dempster | Kevin Correia | Kevin Correia | Ryan Dempster | Joel Hanrahan | 3 | 6 | -3 |
| 2011-04-02 | vs PIT | 2 | W 5-3 | 1-1 | 2 | 35,782 | Carlos Zambrano | Paul Maholm | Sean Marshall | Evan Meek | Carlos Marmol | 8 | 9 | -1 |
| 2011-04-03 | vs PIT | 3 | L 4-5 | 1-2 | 3 | 30,857 | Matt Garza | Ross Ohlendorf | Jeff Karstens | Carlos Marmol | Joel Hanrahan | 12 | 14 | -2 |
| 2011-04-04 | vs ARI | 4 | W 4-1 | 2-2 | 3 | 26,292 | Randy Wells | Joe Saunders | Randy Wells | Joe Saunders | Carlos Marmol | 16 | 15 | 1 |
| 2011-04-05 | vs ARI | 5 | W 6-5 | 3-2 | 2 | 27,039 | Andrew Cashner | Barry Enright | James Russell | Sam Demel | Sean Marshall | 22 | 20 | 2 |
| 2011-04-06 | vs ARI | 6 | L 4-6 | 3-3 | 3 | 32,272 | Ryan Dempster | Armando Galarraga | Armando Galarraga | Ryan Dempster | J.J. Putz | 26 | 26 | 0 |
| 2011-04-08 | @ MIL | 7 | W 7-4 | 4-3 | 3 | 34,310 | Carlos Zambrano | Randy Wolf | Carlos Zambrano | Randy Wolf | Carlos Marmol | 33 | 30 | 3 |
| 2011-04-09 | @ MIL | 8 | L 0-6 | 4-4 | 3 | 42,478 | Matt Garza | Chris Narveson | Chris Narveson | Matt Garza | | 33 | 36 | -3 |
| 2011-04-10 | @ MIL | 9 | L 5-6 | 4-5 | 4 | 37,193 | Casey Coleman | Yovani Gallardo | Kameron Loe | Kerry Wood | John Axford | 38 | 42 | -4 |
| 2011-04-11 | @ HOU | 10 | W 5-4 | 5-5 | 2 | 20,175 | Ryan Dempster | Nelson Figueroa | Ryan Dempster | Nelson Figueroa | Carlos Marmol | 43 | 46 | -3 |
| 2011-04-12 | @ HOU | 11 | L 2-11 | 5-6 | 4 | 23,523 | James Russell | Brett Myers | Brett Myers | James Russell | | 45 | 57 | -12 |
| 2011-04-13 | @ HOU | 12 | W 9-5 | 6-6 | 3 | 20,987 | Carlos Zambrano | Wandy Rodriguez | Carlos Zambrano | Wandy Rodriguez | | 54 | 62 | -8 |
| 2011-04-15 | @ COL | 13 | L 0-5 | 6-7 | 4 | 30,285 | Matt Garza | Jhoulis Chacin | Jhoulis Chacin | Matt Garza | | 54 | 67 | -13 |
| 2011-04-16 | @ COL | 14 | W 8-3 | 7-7 | 4 | 40,264 | Casey Coleman | Jason Hammel | Casey Coleman | Jason Hammel | | 62 | 70 | -8 |
| 2011-04-17 | @ COL | 15 | L 5-9 | 7-8 | 4 | 42,212 | Ryan Dempster | Alan Johnson | Rafael Betancourt | Marcos Mateo | | 67 | 79 | -12 |
| 2011-04-18 | vs SDN | 16 | W 1-0 | 8-8 | 2 | 36,597 | Carlos Zambrano | Tim Stauffer | Carlos Marmol | Chad Qualls | | 68 | 79 | -11 |
| 2011-04-20 | vs SDN | 17 | W 2-1 | 9-9 | 2 | 35,544 | Matt Garza | Dustin Moseley | Jeff Samardzija | Luke Gregerson | | 70 | 80 | -10 |
| 2011-04-20 | vs SDN | 18 | L 4-5 | 9-9 | 2 | 35,095 | James Russell | Aaron Harang | Aaron Harang | James Russell | Heath Bell | 74 | 85 | -11 |
| 2011-04-22 | vs LAN | 19 | L 2-12 | 9-10 | 4 | 36,595 | Casey Coleman | Chad Billingsley | Chad Billingsley | Casey Coleman | | 76 | 97 | -21 |
| 2011-04-23 | vs LAN | 20 | W 10-8 | 10-10 | 3 | 41,161 | Ryan Dempster | Ted Lilly | Jeff Samardzija | Matt Guerrier | Carlos Marmol | 86 | 105 | -19 |
| 2011-04-24 | vs LAN | 21 | L 3-7 | 10-11 | 4 | 32,943 | Carlos Zambrano | Hiroki Kuroda | Hiroki Kuroda | Carlos Zambrano | | 89 | 112 | -23 |
| 2011-04-25 | vs COL | 22 | L 3-5 | 10-12 | 4 | 37,417 | Matt Garza | Esmil Rogers | Esmil Rogers | Matt Garza | Huston Street | 92 | 117 | -25 |
| 2011-04-26 | vs COL | 23 | L 3-4 | 10-13 | 4 | 38,261 | James Russell | Jorge de la Rosa | Jorge de la Rosa | James Russell | Huston Street | 95 | 121 | -26 |
| 2011-04-28 | @ ARI | 24 | L 2-11 | 10-14 | 5 | 21,716 | Ryan Dempster | Barry Enright | Barry Enright | Ryan Dempster | | 97 | 132 | -35 |
| 2011-04-29 | @ ARI | 25 | W 4-2 | 11-14 | 5 | 29,431 | Carlos Zambrano | Armando Galarraga | Carlos Zambrano | Armando Galarraga | Carlos Marmol | 101 | 134 | -33 |
| 2011-04-30 | @ ARI | 26 | W 5-3 | 12-14 | 4 | 27,652 | Matt Garza | Ian Kennedy | Matt Garza | J.J. Putz | Carlos Marmol | 106 | 137 | -31 |
| 2011-05-01 | @ ARI | 27 | L 3-4 | 12-15 | 5 | 26,605 | Casey Coleman | Daniel Hudson | Daniel Hudson | Casey Coleman | J.J. Putz | 109 | 141 | -32 |
| 2011-05-02 | @ LAN | 28 | L 2-5 | 12-16 | 5 | 30,239 | James Russell | Clayton Kershaw | Clayton Kershaw | James Russell | Jonathan Broxton | 111 | 146 | -35 |
| 2011-05-03 | @ LAN | 29 | W 4-1 | 13-16 | 5 | 38,017 | Ryan Dempster | Chad Billingsley | Kerry Wood | Jonathan Broxton | Carlos Marmol | 115 | 147 | -32 |
| 2011-05-04 | @ LAN | 30 | W 5-1 | 14-16 | 4 | 28,419 | Carlos Zambrano | Ted Lilly | Carlos Zambrano | Ted Lilly | | 120 | 148 | -28 |
| 2011-05-06 | vs CIN | 31 | L 4-5 | 14-17 | 4 | 35,471 | Matt Garza | Edinson Volquez | Edinson Volquez | Matt Garza | Francisco Cordero | 124 | 153 | -29 |
| 2011-05-07 | vs CIN | 32 | W 3-2 | 15-17 | 4 | 37,666 | Casey Coleman | Bronson Arroyo | Marcos Mateo | Francisco Cordero | | 127 | 155 | -28 |
| 2011-05-08 | vs CIN | 33 | L 0-2 | 15-18 | 4 | 31,931 | Ryan Dempster | Johnny Cueto | Johnny Cueto | Ryan Dempster | Francisco Cordero | 127 | 157 | -30 |
| 2011-05-10 | vs SLN | 34 | L 4-6 | 15-19 | 5 | 34,249 | Carlos Zambrano | Chris Carpenter | Chris Carpenter | Kerry Wood | Eduardo Sanchez | 131 | 163 | -32 |
| 2011-05-11 | vs SLN | 35 | W 11-4 | 16-19 | 4 | 34,439 | Matt Garza | Jake Westbrook | Matt Garza | Jake Westbrook | | 142 | 167 | -25 |
| 2011-05-12 | vs SLN | 36 | L 1-9 | 16-20 | 4 | 32,559 | Casey Coleman | Jaime Garcia | Jaime Garcia | Casey Coleman | | 143 | 176 | -33 |
| 2011-05-13 | vs SFN | 37 | W 11-4 | 17-20 | 4 | 37,433 | Ryan Dempster | Madison Bumgarner | Ryan Dempster | Madison Bumgarner | | 154 | 180 | -26 |
| 2011-05-14 | vs SFN | 38 | L 0-3 | 17-21 | 5 | 39,706 | Doug Davis | Ryan Vogelsong | Ryan Vogelsong | Doug Davis | | 154 | 183 | -29 |
| 2011-05-16 | @ CIN | 39 | L 4-7 | 17-22 | 5 | 16,981 | Carlos Zambrano | Homer Bailey | Homer Bailey | Carlos Zambrano | Francisco Cordero | 158 | 190 | -32 |
| 2011-05-17 | @ CIN | 40 | L 5-7 | 17-23 | 5 | 18,861 | Matt Garza | Edinson Volquez | Bill Bray | Kerry Wood | Nick Masset | 163 | 197 | -34 |
| 2011-05-18 | @ FLO | 41 | W 7-5 | 18-23 | 5 | 14,422 | Ryan Dempster | Ricky Nolasco | Jeff Samardzija | Edward Mujica | Carlos Marmol | 170 | 202 | -32 |
| 2011-05-19 | @ FLO | 42 | W 5-1 | 19-23 | 5 | 16,345 | Casey Coleman | Chris Volstad | Casey Coleman | Chris Volstad | | 175 | 203 | -28 |
| 2011-05-20 | @ BOS | 43 | L 5-15 | 19-24 | 5 | 37,140 | Doug Davis | Jon Lester | Jon Lester | Doug Davis | Scott Atchison | 180 | 218 | -38 |
| 2011-05-21 | @ BOS | 44 | W 9-3 | 20-24 | 5 | 37,798 | Carlos Zambrano | Alfredo Aceves | Sean Marshall | Matt Albers | | 189 | 221 | -32 |
| 2011-05-22 | @ BOS | 45 | L 1-5 | 20-25 | 5 | 37,688 | James Russell | Tim Wakefield | Tim Wakefield | James Russell | | 190 | 226 | -36 |
| 2011-05-24 | vs NYN | 46 | W 11-1 | 21-25 | 5 | 35,707 | Ryan Dempster | Jonathon Niese | Ryan Dempster | Jonathon Niese | | 201 | 227 | -26 |
| 2011-05-25 | vs NYN | 47 | L 4-7 | 21-26 | 5 | 36,666 | Casey Coleman | Dillon Gee | Dillon Gee | Casey Coleman | | 205 | 234 | -29 |
| 2011-05-26 | vs NYN | 48 | W 9-3 | 22-26 | 4 | 33,378 | Carlos Zambrano | R.A. Dickey | Carlos Zambrano | Pedro Beato | | 214 | 237 | -23 |
| 2011-05-27 | vs PIT | 49 | L 2-4 | 22-27 | 5 | 34,105 | Doug Davis | Kevin Correia | Kevin Correia | Doug Davis | Joel Hanrahan | 216 | 241 | -25 |
| 2011-05-28 | vs PIT | 50 | L 0-10 | 22-28 | 5 | 38,413 | Randy Wells | Paul Maholm | Paul Maholm | Randy Wells | | 216 | 251 | -35 |
| 2011-05-29 | vs PIT | 51 | W 3-2 | 23-28 | 5 | 37,464 | Ryan Dempster | Jeff Karstens | Ryan Dempster | Jeff Karstens | Carlos Marmol | 219 | 253 | -34 |
| 2011-05-30 | vs HOU | 52 | L 7-12 | 23-29 | 5 | 30,450 | Rodrigo Lopez | Aneury Rodriguez | Sergio Escalona | Jeff Samardzija | | 226 | 265 | -39 |
| 2011-05-31 | vs HOU | 53 | L 3-7 | 23-30 | 5 | 31,178 | Carlos Zambrano | Jordan Lyles | Fernando Rodriguez | Carlos Marmol | | 229 | 272 | -43 |
| 2011-06-01 | vs HOU | 54 | L 1-3 | 23-31 | 5 | 31,340 | Doug Davis | Brett Myers | Brett Myers | Doug Davis | Mark Melancon | 230 | 275 | -45 |
| 2011-06-03 | @ SLN | 55 | L 1-6 | 23-32 | 5 | 40,419 | Ryan Dempster | Jaime Garcia | Jaime Garcia | Ryan Dempster | | 231 | 281 | -50 |
| 2011-06-04 | @ SLN | 56 | L 4-5 | 23-33 | 5 | 43,195 | Randy Wells | Kyle Lohse | Eduardo Sanchez | Jeff Samardzija | | 235 | 286 | -51 |
| 2011-06-05 | @ SLN | 57 | L 2-3 | 23-34 | 5 | 40,701 | Carlos Zambrano | Chris Carpenter | Fernando Salas | Rodrigo Lopez | | 237 | 289 | -52 |
| 2011-06-06 | @ CIN | 58 | L 2-8 | 23-35 | 5 | 22,568 | Matt Garza | Mike Leake | Mike Leake | Matt Garza | | 239 | 297 | -58 |
| 2011-06-07 | @ CIN | 59 | L 2-8 | 23-36 | 5 | 24,921 | Doug Davis | Edinson Volquez | Edinson Volquez | Doug Davis | | 241 | 305 | -64 |
| 2011-06-08 | @ CIN | 60 | W 4-1 | 24-36 | 5 | 31,367 | Ryan Dempster | Bronson Arroyo | Ryan Dempster | Bronson Arroyo | Carlos Marmol | 245 | 306 | -61 |
| 2011-06-09 | @ PHI | 61 | W 4-3 | 25-36 | 5 | 44,906 | Randy Wells | Kyle Kendrick | Sean Marshall | David Herndon | Carlos Marmol | 249 | 309 | -60 |
| 2011-06-10 | @ PHI | 62 | L 5-7 | 25-37 | 5 | 45,602 | Carlos Zambrano | Roy Halladay | Roy Halladay | Carlos Zambrano | Antonio Bastardo | 254 | 316 | -62 |
| 2011-06-11 | @ PHI | 63 | L 1-7 | 25-38 | 5 | 45,738 | Matt Garza | Cliff Lee | Cliff Lee | Matt Garza | | 255 | 323 | -68 |
| 2011-06-12 | @ PHI | 64 | L 3-4 | 25-39 | 5 | 45,361 | Doug Davis | Roy Oswalt | Roy Oswalt | Sean Marshall | Ryan Madson | 258 | 327 | -69 |
| 2011-06-13 | vs MIL | 65 | W 1-0 | 26-39 | 5 | 39,070 | Ryan Dempster | Randy Wolf | Jeff Samardzija | Kameron Loe | Carlos Marmol | 259 | 327 | -68 |
| 2011-06-14 | vs MIL | 66 | W 5-4 | 27-39 | 5 | 39,151 | Randy Wells | Yovani Gallardo | Jeff Samardzija | Tim Dillard | | 264 | 331 | -67 |
| 2011-06-15 | vs MIL | 67 | L 5-9 | 27-40 | 5 | 39,821 | Carlos Zambrano | Chris Narveson | Chris Narveson | Carlos Zambrano | | 269 | 340 | -71 |
| 2011-06-16 | vs MIL | 68 | W 12-7 | 28-40 | 5 | 40,024 | Matt Garza | Zack Greinke | Matt Garza | Zack Greinke | | 281 | 347 | -66 |
| 2011-06-17 | vs NYA | 69 | W 3-1 | 29-40 | 5 | 42,219 | Doug Davis | Freddy Garcia | Doug Davis | Freddy Garcia | Carlos Marmol | 284 | 348 | -64 |
| 2011-06-18 | vs NYA | 70 | L 3-4 | 29-41 | 5 | 42,236 | Ryan Dempster | A.J. Burnett | A.J. Burnett | Ryan Dempster | Mariano Rivera | 287 | 352 | -65 |
| 2011-06-19 | vs NYA | 71 | L 4-10 | 29-42 | 5 | 41,828 | Randy Wells | CC Sabathia | CC Sabathia | Sean Marshall | | 291 | 362 | -71 |
| 2011-06-20 | @ CHA | 72 | W 6-3 | 30-42 | 5 | 36,005 | Carlos Zambrano | Gavin Floyd | Carlos Zambrano | Gavin Floyd | Carlos Marmol | 297 | 365 | -68 |
| 2011-06-21 | @ CHA | 73 | L 2-3 | 30-43 | 5 | 35,155 | Matt Garza | Mark Buehrle | Jesse Crain | Jeff Samardzija | Sergio Santos | 299 | 368 | -69 |
| 2011-06-22 | @ CHA | 74 | L 3-4 | 30-44 | 6 | 35,403 | Doug Davis | Jake Peavy | Jake Peavy | Doug Davis | Sergio Santos | 302 | 372 | -70 |
| 2011-06-24 | @ KCA | 75 | W 6-4 | 31-44 | 5 | 32,921 | Ryan Dempster | Bruce Chen | Sean Marshall | Aaron Crow | Carlos Marmol | 308 | 376 | -68 |
| 2011-06-25 | @ KCA | 76 | L 2-3 | 31-45 | 5 | 38,744 | Carlos Zambrano | Danny Duffy | Greg Holland | Jeff Samardzija | Joakim Soria | 310 | 379 | -69 |
| 2011-06-26 | @ KCA | 77 | L 3-6 | 31-46 | 5 | 28,401 | Randy Wells | Luke Hochevar | Luke Hochevar | Randy Wells | Joakim Soria | 313 | 385 | -72 |
| 2011-06-27 | vs COL | 78 | W 7-3 | 32-46 | 5 | 40,854 | Matt Garza | Jhoulis Chacin | Matt Garza | Jhoulis Chacin | | 320 | 388 | -68 |
| 2011-06-28 | vs SFN | 79 | L 7-13 | 32-48 | 6 | 39,157 | Doug Davis | Ryan Vogelsong | Ryan Vogelsong | Doug Davis | | 327 | 401 | -74 |
| 2011-06-28 | vs SFN | 80 | L 3-6 | 32-48 | 6 | 38,360 | Rodrigo Lopez | Barry Zito | Barry Zito | Rodrigo Lopez | Brian Wilson | 330 | 407 | -77 |
| 2011-06-29 | vs SFN | 81 | W 2-1 | 33-48 | 5 | 37,221 | Ryan Dempster | Tim Lincecum | Carlos Marmol | Sergio Romo | | 332 | 408 | -76 |
| 2011-06-30 | vs SFN | 82 | W 5-2 | 34-48 | 5 | 38,158 | Carlos Zambrano | Matt Cain | John Grabow | Ramon Ramirez | | 337 | 410 | -73 |
| 2011-07-01 | vs CHA | 83 | L 4-6 | 34-49 | 5 | 41,486 | Randy Wells | Edwin Jackson | Edwin Jackson | Randy Wells | Sergio Santos | 341 | 416 | -75 |
| 2011-07-02 | vs CHA | 84 | L 0-1 | 34-50 | 6 | 42,165 | Matt Garza | Philip Humber | Philip Humber | Matt Garza | Matt Thornton | 341 | 417 | -76 |
| 2011-07-03 | vs CHA | 85 | W 3-1 | 35-50 | 5 | 42,311 | Rodrigo Lopez | Gavin Floyd | Rodrigo Lopez | Gavin Floyd | Carlos Marmol | 344 | 418 | -74 |
| 2011-07-04 | @ WAS | 86 | L 4-5 | 35-51 | 5 | 32,937 | Casey Coleman | Jordan Zimmermann | Henry Rodriguez | Marcos Mateo | | 348 | 423 | -75 |
| 2011-07-05 | @ WAS | 87 | L 2-3 | 35-52 | 5 | 19,181 | Ramon Ortiz | Ross Detwiler | Ross Detwiler | Ramon Ortiz | Drew Storen | 350 | 426 | -76 |
| 2011-07-06 | @ WAS | 88 | L 4-5 | 35-53 | 5 | 19,631 | Randy Wells | Tom Gorzelanny | Ryan Mattheus | Kerry Wood | Drew Storen | 354 | 431 | -77 |
| 2011-07-07 | @ WAS | 89 | W 10-9 | 36-53 | 5 | 22,016 | Matt Garza | Livan Hernandez | Sean Marshall | Henry Rodriguez | Carlos Marmol | 364 | 440 | -76 |
| 2011-07-08 | @ PIT | 90 | L 4-7 | 36-54 | 5 | 37,140 | Rodrigo Lopez | James McDonald | Daniel McCutchen | Sean Marshall | Joel Hanrahan | 368 | 447 | -79 |
| 2011-07-09 | @ PIT | 91 | W 6-3 | 37-54 | 5 | 39,235 | Ryan Dempster | Kevin Correia | Ryan Dempster | Kevin Correia | Carlos Marmol | 374 | 450 | -76 |
| 2011-07-10 | @ PIT | 92 | L 1-9 | 37-55 | 5 | 31,428 | Ramon Ortiz | Paul Maholm | Paul Maholm | Ramon Ortiz | | 375 | 459 | -84 |
| 2011-07-14 | vs FLO | 93 | L 3-6 | 37-56 | 5 | 38,145 | Matt Garza | Anibal Sanchez | Edward Mujica | Carlos Marmol | | 378 | 465 | -87 |
| 2011-07-15 | vs FLO | 94 | W 2-1 | 38-56 | 5 | 38,391 | Ryan Dempster | Ricky Nolasco | Ryan Dempster | Ricky Nolasco | Sean Marshall | 380 | 466 | -86 |
| 2011-07-16 | vs FLO | 95 | L 3-13 | 38-57 | 5 | 40,709 | Carlos Zambrano | Javier Vazquez | Javier Vazquez | Carlos Zambrano | | 383 | 479 | -96 |
| 2011-07-17 | vs FLO | 96 | L 5-7 | 38-58 | 5 | 37,634 | Randy Wells | Chris Volstad | Edward Mujica | Kerry Wood | Leo Nunez | 388 | 486 | -98 |
| 2011-07-18 | vs PHI | 97 | W 6-1 | 39-58 | 5 | 38,183 | Rodrigo Lopez | Roy Halladay | Rodrigo Lopez | Roy Halladay | | 394 | 487 | -93 |
| 2011-07-19 | vs PHI | 98 | L 2-4 | 39-59 | 5 | 38,857 | Matt Garza | Cliff Lee | Michael Stutes | Sean Marshall | Antonio Bastardo | 396 | 491 | -95 |
| 2011-07-20 | vs PHI | 99 | L 1-9 | 39-60 | 5 | 37,864 | Ryan Dempster | Vance Worley | Vance Worley | Ryan Dempster | | 397 | 500 | -103 |
| 2011-07-22 | vs HOU | 100 | W 4-2 | 40-60 | 5 | 39,855 | Carlos Zambrano | Bud Norris | Carlos Zambrano | Bud Norris | Sean Marshall | 401 | 502 | -101 |
| 2011-07-23 | vs HOU | 101 | W 5-1 | 41-60 | 5 | 40,486 | Randy Wells | Wandy Rodriguez | Randy Wells | Wandy Rodriguez | | 406 | 503 | -97 |
| 2011-07-24 | vs HOU | 102 | W 5-4 | 42-60 | 5 | 40,406 | Matt Garza | Jordan Lyles | John Grabow | David Carpenter | | 411 | 507 | -96 |
| 2011-07-26 | @ MIL | 103 | L 2-3 | 42-61 | 5 | 39,183 | Ryan Dempster | Chris Narveson | Chris Narveson | Ryan Dempster | John Axford | 413 | 510 | -97 |
| 2011-07-27 | @ MIL | 104 | L 0-2 | 42-62 | 5 | 39,233 | Carlos Zambrano | Zack Greinke | Zack Greinke | Carlos Zambrano | John Axford | 413 | 512 | -99 |
| 2011-07-28 | @ MIL | 105 | L 2-4 | 42-63 | 5 | 40,008 | Randy Wells | Shaun Marcum | Shaun Marcum | Randy Wells | John Axford | 415 | 516 | -101 |
| 2011-07-29 | @ SLN | 106 | L 2-9 | 42-64 | 5 | 42,042 | Matt Garza | Edwin Jackson | Edwin Jackson | Matt Garza | | 417 | 525 | -108 |
| 2011-07-30 | @ SLN | 107 | L 5-13 | 42-65 | 5 | 43,784 | Rodrigo Lopez | Kyle Lohse | Kyle Lohse | Rodrigo Lopez | | 422 | 538 | -116 |
| 2011-07-31 | @ SLN | 108 | W 6-3 | 43-65 | 5 | 43,960 | Ryan Dempster | Jake Westbrook | Ryan Dempster | Jake Westbrook | Carlos Marmol | 428 | 541 | -113 |
| 2011-08-01 | @ PIT | 109 | W 5-3 | 44-65 | 5 | 22,248 | Carlos Zambrano | Paul Maholm | Carlos Zambrano | Paul Maholm | Carlos Marmol | 433 | 544 | -111 |
| 2011-08-02 | @ PIT | 110 | W 11-6 | 45-65 | 5 | 26,109 | Randy Wells | Kevin Correia | Randy Wells | Kevin Correia | | 444 | 550 | -106 |
| 2011-08-03 | @ PIT | 111 | W 1-0 | 46-65 | 5 | 19,106 | Matt Garza | Charlie Morton | Matt Garza | Chris Resop | Carlos Marmol | 445 | 550 | -105 |
| 2011-08-04 | @ PIT | 112 | W 7-6 | 47-65 | 5 | 29,317 | Rodrigo Lopez | James McDonald | Jeff Samardzija | Daniel McCutchen | Carlos Marmol | 452 | 556 | -104 |
| 2011-08-05 | vs CIN | 113 | W 4-3 | 48-65 | 5 | 42,245 | Ryan Dempster | Mike Leake | Ryan Dempster | Mike Leake | Carlos Marmol | 456 | 559 | -103 |
| 2011-08-06 | vs CIN | 114 | W 11-4 | 49-65 | 5 | 41,978 | Carlos Zambrano | Johnny Cueto | Carlos Zambrano | Johnny Cueto | | 467 | 563 | -96 |
| 2011-08-07 | vs CIN | 115 | L 7-8 | 49-66 | 5 | 39,619 | Randy Wells | Bronson Arroyo | Nick Masset | Sean Marshall | Francisco Cordero | 474 | 571 | -97 |
| 2011-08-09 | vs WAS | 116 | L 1-3 | 49-67 | 5 | 37,109 | Matt Garza | Chien-Ming Wang | Chien-Ming Wang | Matt Garza | Drew Storen | 475 | 574 | -99 |
| 2011-08-10 | vs WAS | 117 | W 4-2 | 50-67 | 5 | 38,010 | Rodrigo Lopez | Ross Detwiler | Rodrigo Lopez | Ross Detwiler | Carlos Marmol | 479 | 576 | -97 |
| 2011-08-11 | vs WAS | 118 | W 4-3 | 51-67 | 5 | 34,733 | Ryan Dempster | Jordan Zimmermann | Ryan Dempster | Jordan Zimmermann | Carlos Marmol | 483 | 579 | -96 |
| 2011-08-12 | @ ATL | 119 | L 4-10 | 51-68 | 5 | 50,146 | Carlos Zambrano | Mike Minor | Mike Minor | Carlos Zambrano | | 487 | 589 | -102 |
| 2011-08-13 | @ ATL | 120 | W 8-4 | 52-68 | 5 | 49,781 | Randy Wells | Derek Lowe | Randy Wells | Derek Lowe | Carlos Marmol | 495 | 593 | -98 |
| 2011-08-14 | @ ATL | 121 | W 6-5 | 53-68 | 5 | 32,011 | Matt Garza | Brandon Beachy | John Grabow | Eric O'Flaherty | Carlos Marmol | 501 | 598 | -97 |
| 2011-08-15 | @ HOU | 122 | W 4-3 | 54-68 | 5 | 20,138 | Rodrigo Lopez | Henry Sosa | Rodrigo Lopez | Henry Sosa | Kerry Wood | 505 | 601 | -96 |
| 2011-08-16 | @ HOU | 123 | L 5-6 | 54-69 | 5 | 23,736 | Ryan Dempster | Brett Myers | Aneury Rodriguez | Carlos Marmol | | 510 | 607 | -97 |
| 2011-08-17 | @ HOU | 124 | L 3-4 | 54-70 | 5 | 24,054 | Casey Coleman | Bud Norris | Bud Norris | Casey Coleman | Mark Melancon | 513 | 611 | -98 |
| 2011-08-19 | vs SLN | 125 | W 5-4 | 55-70 | 5 | 42,343 | Randy Wells | Jaime Garcia | Sean Marshall | Octavio Dotel | | 518 | 615 | -97 |
| 2011-08-20 | vs SLN | 126 | W 3-0 | 56-70 | 5 | 42,374 | Matt Garza | Edwin Jackson | Matt Garza | Edwin Jackson | Carlos Marmol | 521 | 615 | -94 |
| 2011-08-21 | vs SLN | 127 | L 2-6 | 56-71 | 5 | 39,420 | Rodrigo Lopez | Jake Westbrook | Jake Westbrook | Rodrigo Lopez | | 523 | 621 | -98 |
| 2011-08-22 | vs ATL | 128 | L 0-3 | 56-72 | 7 | 37,061 | Ryan Dempster | Jair Jurrjens | Jair Jurrjens | Ryan Dempster | Jonny Venters | 523 | 624 | -101 |
| 2011-08-23 | vs ATL | 129 | L 4-5 | 56-73 | 5 | 36,639 | Casey Coleman | Mike Minor | Mike Minor | Casey Coleman | Craig Kimbrel | 527 | 629 | -102 |
| 2011-08-24 | vs ATL | 130 | W 3-2 | 57-73 | 6 | 37,098 | Randy Wells | Derek Lowe | Randy Wells | Derek Lowe | Carlos Marmol | 530 | 631 | -101 |
| 2011-08-25 | vs ATL | 131 | L 3-8 | 57-74 | 5 | 36,136 | Matt Garza | Brandon Beachy | Brandon Beachy | Matt Garza | | 533 | 639 | -106 |
| 2011-08-26 | @ MIL | 132 | L 2-5 | 57-75 | 5 | 41,661 | Rodrigo Lopez | Randy Wolf | Randy Wolf | Rodrigo Lopez | John Axford | 535 | 644 | -109 |
| 2011-08-27 | @ MIL | 133 | L 4-6 | 57-76 | 5 | 44,091 | Ryan Dempster | Yovani Gallardo | Yovani Gallardo | Ryan Dempster | John Axford | 539 | 650 | -111 |
| 2011-08-28 | @ MIL | 134 | L 2-3 | 57-77 | 5 | 41,883 | Casey Coleman | Zack Greinke | Zack Greinke | Casey Coleman | John Axford | 541 | 653 | -112 |
| 2011-08-29 | @ SFN | 135 | W 7-0 | 58-77 | 5 | 41,063 | Randy Wells | Tim Lincecum | Randy Wells | Tim Lincecum | | 548 | 653 | -105 |
| 2011-08-30 | @ SFN | 136 | W 5-2 | 59-77 | 5 | 41,165 | Matt Garza | Ryan Vogelsong | Matt Garza | Ryan Vogelsong | Carlos Marmol | 553 | 655 | -102 |
| 2011-08-31 | @ SFN | 137 | L 0-4 | 59-78 | 5 | 41,099 | Rodrigo Lopez | Madison Bumgarner | Madison Bumgarner | Rodrigo Lopez | | 553 | 659 | -106 |
| 2011-09-02 | vs PIT | 138 | L 1-3 | 59-79 | 5 | 35,153 | Ryan Dempster | Brian Burres | Brian Burres | Ryan Dempster | Joel Hanrahan | 554 | 662 | -108 |
| 2011-09-03 | vs PIT | 139 | L 5-7 | 59-80 | 5 | 36,628 | Casey Coleman | Ross Ohlendorf | Chris Resop | Carlos Marmol | Joel Hanrahan | 559 | 669 | -110 |
| 2011-09-04 | vs PIT | 140 | W 6-3 | 60-80 | 5 | 40,469 | Randy Wells | Charlie Morton | Randy Wells | Charlie Morton | Sean Marshall | 565 | 672 | -107 |
| 2011-09-05 | vs CIN | 141 | W 4-3 | 61-80 | 5 | 41,341 | Matt Garza | Dontrelle Willis | Matt Garza | Dontrelle Willis | Carlos Marmol | 569 | 675 | -106 |
| 2011-09-06 | vs CIN | 142 | L 2-4 | 61-81 | 5 | 35,297 | Rodrigo Lopez | Mike Leake | Aroldis Chapman | John Grabow | Francisco Cordero | 571 | 679 | -108 |
| 2011-09-07 | vs CIN | 143 | W 6-3 | 62-81 | 5 | 36,797 | Ryan Dempster | Johnny Cueto | Kerry Wood | Logan Ondrusek | Carlos Marmol | 577 | 682 | -105 |
| 2011-09-09 | @ NYN | 144 | L 4-5 | 62-82 | 5 | 27,639 | Casey Coleman | Mike Pelfrey | Manny Acosta | Sean Marshall | | 581 | 687 | -106 |
| 2011-09-10 | @ NYN | 145 | W 5-4 | 63-82 | 5 | 30,443 | Randy Wells | Chris Capuano | Kerry Wood | Bobby Parnell | Carlos Marmol | 586 | 691 | -105 |
| 2011-09-11 | @ NYN | 146 | W 10-6 | 64-82 | 5 | 33,502 | Matt Garza | Miguel Batista | Ramon Ortiz | Josh Stinson | | 596 | 697 | -101 |
| 2011-09-12 | @ CIN | 147 | W 12-8 | 65-82 | 5 | 19,874 | Rodrigo Lopez | Dontrelle Willis | Rodrigo Lopez | Dontrelle Willis | | 608 | 705 | -97 |
| 2011-09-13 | @ CIN | 148 | L 1-2 | 65-83 | 5 | 19,159 | Ryan Dempster | Mike Leake | Mike Leake | Ryan Dempster | Francisco Cordero | 609 | 707 | -98 |
| 2011-09-14 | @ CIN | 149 | L 2-7 | 65-84 | 5 | 18,304 | Casey Coleman | Johnny Cueto | Sam LeCure | Casey Coleman | | 611 | 714 | -103 |
| 2011-09-15 | @ CIN | 150 | L 6-8 | 65-85 | 5 | 23,792 | Randy Wells | Homer Bailey | Nick Masset | James Russell | | 617 | 722 | -105 |
| 2011-09-16 | vs HOU | 151 | W 4-3 | 66-85 | 5 | 35,318 | Matt Garza | Wandy Rodriguez | Jeff Samardzija | David Carpenter | | 621 | 725 | -104 |
| 2011-09-17 | vs HOU | 152 | W 2-1 | 67-85 | 5 | 39,377 | Rodrigo Lopez | Henry Sosa | Rodrigo Lopez | Henry Sosa | Sean Marshall | 623 | 726 | -103 |
| 2011-09-18 | vs HOU | 153 | L 2-3 | 67-86 | 5 | 36,250 | Ryan Dempster | Brett Myers | Brett Myers | Ryan Dempster | Mark Melancon | 625 | 729 | -104 |
| 2011-09-19 | vs MIL | 154 | W 5-2 | 68-86 | 4 | 35,076 | Casey Coleman | Chris Narveson | Casey Coleman | Chris Narveson | | 630 | 731 | -101 |
| 2011-09-20 | vs MIL | 155 | L 1-5 | 68-87 | 5 | 36,571 | Randy Wells | Shaun Marcum | Shaun Marcum | Randy Wells | | 631 | 736 | -105 |
| 2011-09-21 | vs MIL | 156 | W 7-1 | 69-87 | 4 | 30,965 | Matt Garza | Randy Wolf | Matt Garza | Randy Wolf | | 638 | 737 | -99 |
| 2011-09-23 | @ SLN | 157 | W 5-1 | 70-87 | 4 | 40,355 | Ryan Dempster | Chris Carpenter | Jeff Samardzija | Kyle McClellan | | 643 | 738 | -95 |
| 2011-09-24 | @ SLN | 158 | L 1-2 | 70-88 | 5 | 42,571 | Rodrigo Lopez | Kyle Lohse | Jason Motte | Carlos Marmol | | 644 | 740 | -96 |
| 2011-09-25 | @ SLN | 159 | L 2-3 | 70-89 | 5 | 41,469 | Randy Wells | Edwin Jackson | Octavio Dotel | Randy Wells | Jason Motte | 646 | 743 | -97 |
| 2011-09-26 | @ SDN | 160 | L 0-2 | 70-90 | 5 | 26,433 | Casey Coleman | Mat Latos | Mat Latos | Casey Coleman | Heath Bell | 646 | 745 | -99 |
| 2011-09-27 | @ SDN | 161 | W 6-2 | 71-90 | 5 | 39,058 | Matt Garza | Anthony Bass | Matt Garza | Chad Qualls | | 652 | 747 | -95 |
| 2011-09-28 | @ SDN | 162 | L 2-9 | 71-91 | 5 | 32,452 | Ryan Dempster | Wade LeBlanc | Wade LeBlanc | Ryan Dempster | | 654 | 756 | -102 |