| 2011-04-01 | @ TBA | 1 | W 4-1 | 1-0 | 1 | 34,078 | Jeremy Guthrie | David Price | Jeremy Guthrie | David Price | | 4 | 1 | 3 |
| 2011-04-02 | @ TBA | 2 | W 3-1 | 2-0 | 1 | 22,164 | Chris Tillman | James Shields | Jeremy Accardo | James Shields | Kevin Gregg | 7 | 2 | 5 |
| 2011-04-03 | @ TBA | 3 | W 5-1 | 3-0 | 1 | 17,408 | Zachary Britton | Wade Davis | Zachary Britton | Wade Davis | | 12 | 3 | 9 |
| 2011-04-04 | vs DET | 4 | W 5-1 | 4-0 | 1 | 46,593 | Jake Arrieta | Rick Porcello | Jake Arrieta | Rick Porcello | | 17 | 4 | 13 |
| 2011-04-06 | vs DET | 5 | L 3-7 | 4-1 | 1 | 12,451 | Brad Bergesen | Justin Verlander | Justin Verlander | Brad Bergesen | | 20 | 11 | 9 |
| 2011-04-07 | vs DET | 6 | W 9-5 | 5-1 | 1 | 11,648 | Chris Tillman | Brad Penny | Jim Johnson | Brad Thomas | | 29 | 16 | 13 |
| 2011-04-09 | vs TEX | 7 | W 5-0 | 6-2 | 2 | 0 | Zachary Britton | Colby Lewis | Zachary Britton | Colby Lewis | | 34 | 16 | 18 |
| 2011-04-09 | vs TEX | 8 | L 1-13 | 6-2 | 2 | 36,243 | Jake Arrieta | Matt Harrison | Matt Harrison | Jake Arrieta | | 35 | 29 | 6 |
| 2011-04-10 | vs TEX | 9 | L 0-3 | 6-3 | 1 | 21,452 | Jeremy Guthrie | Derek Holland | Derek Holland | Jeremy Guthrie | Neftali Feliz | 35 | 32 | 3 |
| 2011-04-13 | @ NYA | 10 | L 4-7 | 6-4 | 1 | 42,171 | Chris Tillman | A.J. Burnett | A.J. Burnett | Chris Tillman | Mariano Rivera | 39 | 39 | 0 |
| 2011-04-14 | @ NYA | 11 | L 5-6 | 6-5 | 2 | 40,517 | Jake Arrieta | Phil Hughes | Mariano Rivera | Mike Gonzalez | | 44 | 45 | -1 |
| 2011-04-15 | @ CLE | 12 | L 2-8 | 6-6 | 3 | 16,346 | Zachary Britton | Justin Masterson | Justin Masterson | Zachary Britton | | 46 | 53 | -7 |
| 2011-04-16 | @ CLE | 13 | L 3-8 | 6-7 | 3 | 10,714 | Jeremy Guthrie | Josh Tomlin | Josh Tomlin | Jeremy Guthrie | | 49 | 61 | -12 |
| 2011-04-17 | @ CLE | 14 | L 2-4 | 6-8 | 3 | 13,017 | Brad Bergesen | Fausto Carmona | Fausto Carmona | Brad Bergesen | Chris Perez | 51 | 65 | -14 |
| 2011-04-18 | vs MIN | 15 | L 3-5 | 6-9 | 4 | 13,138 | Chris Tillman | Francisco Liriano | Francisco Liriano | Chris Tillman | Matt Capps | 54 | 70 | -16 |
| 2011-04-19 | vs MIN | 16 | W 11-0 | 7-9 | 4 | 12,045 | Jake Arrieta | Carl Pavano | Jake Arrieta | Carl Pavano | | 65 | 70 | -5 |
| 2011-04-20 | vs MIN | 17 | W 5-4 | 8-9 | 3 | 13,825 | Zachary Britton | Nick Blackburn | Zachary Britton | Nick Blackburn | Kevin Gregg | 70 | 74 | -4 |
| 2011-04-21 | vs MIN | 18 | L 1-3 | 8-10 | 3 | 16,769 | Jeremy Guthrie | Scott Baker | Scott Baker | Jeremy Guthrie | Matt Capps | 71 | 77 | -6 |
| 2011-04-23 | vs NYA | 19 | L 3-15 | 8-11 | 5 | 39,054 | Brad Bergesen | CC Sabathia | CC Sabathia | Brad Bergesen | | 74 | 92 | -18 |
| 2011-04-24 | vs NYA | 20 | L 3-6 | 8-12 | 5 | 25,051 | Jake Arrieta | Freddy Garcia | Boone Logan | Jason Berken | | 77 | 98 | -21 |
| 2011-04-26 | vs BOS | 21 | W 4-1 | 9-12 | 5 | 18,938 | Zachary Britton | Clay Buchholz | Zachary Britton | Clay Buchholz | Kevin Gregg | 81 | 99 | -18 |
| 2011-04-27 | vs BOS | 22 | W 5-4 | 10-12 | 4 | 15,514 | Jeremy Guthrie | Josh Beckett | Koji Uehara | Daniel Bard | Kevin Gregg | 86 | 103 | -17 |
| 2011-04-28 | vs BOS | 23 | L 2-6 | 10-13 | 6 | 21,209 | Brad Bergesen | Jon Lester | Jon Lester | Jim Johnson | | 88 | 109 | -21 |
| 2011-04-29 | @ CHA | 24 | W 10-4 | 11-13 | 4 | 21,816 | Jake Arrieta | John Danks | Jake Arrieta | John Danks | | 98 | 113 | -15 |
| 2011-04-30 | @ CHA | 25 | W 6-2 | 12-13 | 4 | 26,104 | Chris Tillman | Philip Humber | Chris Tillman | Philip Humber | | 104 | 115 | -11 |
| 2011-05-01 | @ CHA | 26 | W 6-4 | 13-13 | 3 | 22,029 | Zachary Britton | Gavin Floyd | Zachary Britton | Gavin Floyd | Kevin Gregg | 110 | 119 | -9 |
| 2011-05-02 | @ CHA | 27 | L 2-6 | 13-14 | 3 | 18,007 | Jeremy Guthrie | Mark Buehrle | Mark Buehrle | Jeremy Guthrie | Sergio Santos | 112 | 125 | -13 |
| 2011-05-03 | @ KCA | 28 | L 5-6 | 13-15 | 4 | 11,986 | Brad Bergesen | Jeff Francis | Tim Collins | Jason Berken | | 117 | 131 | -14 |
| 2011-05-04 | @ KCA | 29 | W 3-2 | 14-15 | 3 | 11,130 | Jake Arrieta | Kyle Davies | Jake Arrieta | Kyle Davies | Kevin Gregg | 120 | 133 | -13 |
| 2011-05-05 | @ KCA | 30 | L 1-9 | 14-16 | 3 | 29,927 | Chris Tillman | Bruce Chen | Bruce Chen | Chris Tillman | | 121 | 142 | -21 |
| 2011-05-06 | vs TBA | 31 | L 2-6 | 14-17 | 4 | 20,694 | Zachary Britton | James Shields | James Shields | Zachary Britton | | 123 | 148 | -25 |
| 2011-05-07 | vs TBA | 32 | L 2-8 | 14-18 | 5 | 18,961 | Jeremy Guthrie | Jeremy Hellickson | Jeremy Hellickson | Jeremy Guthrie | | 125 | 156 | -31 |
| 2011-05-08 | vs TBA | 33 | L 3-5 | 14-19 | 5 | 16,359 | Brad Bergesen | Wade Davis | Wade Davis | Brad Bergesen | Kyle Farnsworth | 128 | 161 | -33 |
| 2011-05-10 | vs SEA | 34 | W 7-6 | 15-19 | 5 | 11,485 | Jake Arrieta | Michael Pineda | Jeremy Accardo | Brandon League | | 135 | 167 | -32 |
| 2011-05-11 | vs SEA | 35 | W 4-2 | 16-19 | 5 | 11,561 | Chris Tillman | Felix Hernandez | Chris Tillman | Felix Hernandez | Kevin Gregg | 139 | 169 | -30 |
| 2011-05-12 | vs SEA | 36 | W 2-1 | 17-19 | 3 | 19,082 | Zachary Britton | Jason Vargas | Jim Johnson | Brandon League | | 141 | 170 | -29 |
| 2011-05-13 | @ TBA | 37 | L 0-3 | 17-20 | 5 | 20,476 | Jeremy Guthrie | Jeremy Hellickson | Jeremy Hellickson | Jeremy Guthrie | | 141 | 173 | -32 |
| 2011-05-14 | @ TBA | 38 | W 6-0 | 18-20 | 5 | 28,451 | Brad Bergesen | Wade Davis | Brad Bergesen | Wade Davis | | 147 | 173 | -26 |
| 2011-05-15 | @ TBA | 39 | W 9-3 | 19-20 | 5 | 21,505 | Jake Arrieta | Andy Sonnanstine | Jake Arrieta | Andy Sonnanstine | | 156 | 176 | -20 |
| 2011-05-16 | @ BOS | 40 | L 7-8 | 19-21 | 5 | 37,138 | Chris Tillman | Daisuke Matsuzaka | Alfredo Aceves | Kevin Gregg | | 163 | 184 | -21 |
| 2011-05-18 | vs NYA | 41 | L 1-4 | 19-22 | 5 | 20,589 | Zachary Britton | Bartolo Colon | Hector Noesi | Jeremy Accardo | | 164 | 188 | -24 |
| 2011-05-19 | vs NYA | 42 | L 2-13 | 19-23 | 5 | 24,939 | Brad Bergesen | CC Sabathia | CC Sabathia | Brad Bergesen | | 166 | 201 | -35 |
| 2011-05-20 | vs WAS | 43 | L 5-17 | 19-24 | 5 | 24,442 | Jake Arrieta | Jason Marquis | Henry Rodriguez | Jake Arrieta | | 171 | 218 | -47 |
| 2011-05-21 | vs WAS | 44 | W 8-3 | 20-24 | 5 | 33,107 | Jeremy Guthrie | John Lannan | Jeremy Guthrie | John Lannan | | 179 | 221 | -42 |
| 2011-05-22 | vs WAS | 45 | W 2-1 | 21-24 | 5 | 33,626 | Chris Tillman | Jordan Zimmermann | Jim Johnson | Jordan Zimmermann | Kevin Gregg | 181 | 222 | -41 |
| 2011-05-24 | vs KCA | 46 | W 5-3 | 22-24 | 5 | 14,077 | Zachary Britton | Danny Duffy | Alfredo Simon | Joakim Soria | | 186 | 225 | -39 |
| 2011-05-25 | vs KCA | 47 | W 9-2 | 23-24 | 5 | 15,740 | Jake Arrieta | Luke Hochevar | Jake Arrieta | Luke Hochevar | | 195 | 227 | -32 |
| 2011-05-26 | vs KCA | 48 | W 6-5 | 24-24 | 4 | 22,720 | Jeremy Guthrie | Jeff Francis | Jeremy Accardo | Louis Coleman | | 201 | 232 | -31 |
| 2011-05-27 | @ OAK | 49 | L 2-6 | 24-25 | 5 | 12,110 | Chris Tillman | Gio Gonzalez | Brad Ziegler | Alfredo Simon | | 203 | 238 | -35 |
| 2011-05-28 | @ OAK | 50 | L 2-4 | 24-26 | 5 | 23,795 | Brad Bergesen | Josh Outman | Josh Outman | Brad Bergesen | Brian Fuentes | 205 | 242 | -37 |
| 2011-05-29 | @ OAK | 51 | L 4-6 | 24-27 | 6 | 15,373 | Zachary Britton | Guillermo Moscoso | Guillermo Moscoso | Zachary Britton | Brian Fuentes | 209 | 248 | -39 |
| 2011-05-30 | @ SEA | 52 | L 3-4 | 24-28 | 5 | 22,819 | Jake Arrieta | Doug Fister | Doug Fister | Jake Arrieta | Brandon League | 212 | 252 | -40 |
| 2011-05-31 | @ SEA | 53 | L 2-3 | 24-29 | 5 | 11,692 | Jeremy Guthrie | Erik Bedard | Chris Ray | Jeremy Guthrie | Brandon League | 214 | 255 | -41 |
| 2011-06-01 | @ SEA | 54 | W 2-1 | 25-29 | 5 | 18,036 | Brian Matusz | Michael Pineda | Jim Johnson | Jamey Wright | Kevin Gregg | 216 | 256 | -40 |
| 2011-06-03 | vs TOR | 55 | L 4-8 | 25-30 | 5 | 18,587 | Zachary Britton | Carlos Villanueva | Carlos Villanueva | Zachary Britton | | 220 | 264 | -44 |
| 2011-06-04 | vs TOR | 56 | W 5-3 | 26-30 | 5 | 20,086 | Jake Arrieta | Ricky Romero | Jake Arrieta | Ricky Romero | Kevin Gregg | 225 | 267 | -42 |
| 2011-06-05 | vs TOR | 57 | L 4-7 | 26-31 | 5 | 25,431 | Jeremy Guthrie | Jo-Jo Reyes | Jo-Jo Reyes | Jeremy Guthrie | | 229 | 274 | -45 |
| 2011-06-06 | vs OAK | 58 | W 4-2 | 27-31 | 5 | 10,556 | Brian Matusz | Gio Gonzalez | Brian Matusz | Gio Gonzalez | Kevin Gregg | 233 | 276 | -43 |
| 2011-06-07 | vs OAK | 59 | W 4-0 | 28-31 | 5 | 13,652 | Chris Jakubauskas | Guillermo Moscoso | Chris Jakubauskas | Guillermo Moscoso | | 237 | 276 | -39 |
| 2011-06-08 | vs OAK | 60 | W 3-2 | 29-31 | 5 | 11,760 | Zachary Britton | Josh Outman | Zachary Britton | Josh Outman | Kevin Gregg | 240 | 278 | -38 |
| 2011-06-10 | vs TBA | 61 | W 7-0 | 30-31 | 5 | 17,900 | Jake Arrieta | Jeremy Hellickson | Jake Arrieta | Jeremy Hellickson | | 247 | 278 | -31 |
| 2011-06-11 | vs TBA | 62 | L 5-7 | 30-32 | 5 | 25,541 | Jeremy Guthrie | David Price | Juan Cruz | Jeremy Accardo | Kyle Farnsworth | 252 | 285 | -33 |
| 2011-06-12 | vs TBA | 63 | L 6-9 | 30-33 | 5 | 22,032 | Brian Matusz | Wade Davis | Wade Davis | Brian Matusz | J.P. Howell | 258 | 294 | -36 |
| 2011-06-14 | @ TOR | 64 | L 5-6 | 30-34 | 5 | 15,592 | Chris Jakubauskas | Carlos Villanueva | Shawn Camp | Koji Uehara | | 263 | 300 | -37 |
| 2011-06-15 | @ TOR | 65 | L 1-4 | 30-35 | 5 | 14,541 | Jake Arrieta | Ricky Romero | Ricky Romero | Jake Arrieta | Frank Francisco | 264 | 304 | -40 |
| 2011-06-16 | @ TOR | 66 | W 4-3 | 31-35 | 5 | 31,822 | Jeremy Guthrie | Zach Stewart | Jason Berken | Jon Rauch | Kevin Gregg | 268 | 307 | -39 |
| 2011-06-17 | @ WAS | 67 | L 4-8 | 31-36 | 5 | 35,562 | Zachary Britton | Jason Marquis | Sean Burnett | Jeremy Accardo | | 272 | 315 | -43 |
| 2011-06-18 | @ WAS | 68 | L 2-4 | 31-37 | 5 | 36,614 | Brian Matusz | Jordan Zimmermann | Jordan Zimmermann | Brian Matusz | Drew Storen | 274 | 319 | -45 |
| 2011-06-19 | @ WAS | 69 | W 7-4 | 32-37 | 5 | 35,439 | Chris Jakubauskas | Tom Gorzelanny | Chris Jakubauskas | Tom Gorzelanny | | 281 | 323 | -42 |
| 2011-06-20 | @ PIT | 70 | W 8-3 | 33-37 | 5 | 22,447 | Jake Arrieta | Charlie Morton | Jake Arrieta | Charlie Morton | | 289 | 326 | -37 |
| 2011-06-21 | @ PIT | 71 | L 3-9 | 33-38 | 5 | 33,806 | Jeremy Guthrie | James McDonald | Chris Resop | Jeremy Guthrie | | 292 | 335 | -43 |
| 2011-06-22 | @ PIT | 72 | L 4-5 | 33-39 | 6 | 19,418 | Zachary Britton | Kevin Correia | Kevin Correia | Zachary Britton | Joel Hanrahan | 296 | 340 | -44 |
| 2011-06-24 | vs CIN | 73 | W 5-4 | 34-39 | 5 | 45,382 | Chris Jakubauskas | Edinson Volquez | Mike Gonzalez | Jose Arredondo | | 301 | 344 | -43 |
| 2011-06-25 | vs CIN | 74 | L 5-10 | 34-40 | 5 | 38,976 | Brian Matusz | Bronson Arroyo | Bronson Arroyo | Brian Matusz | | 306 | 354 | -48 |
| 2011-06-26 | vs CIN | 75 | W 7-5 | 35-40 | 5 | 27,809 | Jeremy Guthrie | Homer Bailey | Jeremy Guthrie | Homer Bailey | Kevin Gregg | 313 | 359 | -46 |
| 2011-06-28 | vs SLN | 76 | L 2-6 | 35-41 | 5 | 20,556 | Zachary Britton | Kyle Lohse | Kyle Lohse | Zachary Britton | | 315 | 365 | -50 |
| 2011-06-29 | vs SLN | 77 | L 1-5 | 35-42 | 5 | 17,405 | Chris Jakubauskas | Chris Carpenter | Chris Carpenter | Chris Jakubauskas | | 316 | 370 | -54 |
| 2011-06-30 | vs SLN | 78 | L 6-9 | 35-43 | 5 | 28,340 | Brian Matusz | Jaime Garcia | Jaime Garcia | Brian Matusz | Fernando Salas | 322 | 379 | -57 |
| 2011-07-01 | @ ATL | 79 | L 0-4 | 35-44 | 5 | 33,261 | Jeremy Guthrie | Jair Jurrjens | Jair Jurrjens | Jeremy Guthrie | | 322 | 383 | -61 |
| 2011-07-02 | @ ATL | 80 | L 4-5 | 35-45 | 5 | 37,259 | Jake Arrieta | Tim Hudson | Tim Hudson | Jake Arrieta | Craig Kimbrel | 326 | 388 | -62 |
| 2011-07-03 | @ ATL | 81 | W 5-4 | 36-45 | 5 | 23,492 | Zachary Britton | Brandon Beachy | Jim Johnson | Scott Proctor | Kevin Gregg | 331 | 392 | -61 |
| 2011-07-04 | @ TEX | 82 | L 4-13 | 36-46 | 5 | 42,885 | Chris Jakubauskas | Colby Lewis | Colby Lewis | Chris Jakubauskas | | 335 | 405 | -70 |
| 2011-07-05 | @ TEX | 83 | L 2-4 | 36-47 | 5 | 25,945 | Mitch Atkins | Matt Harrison | Tommy Hunter | Jim Johnson | Neftali Feliz | 337 | 409 | -72 |
| 2011-07-06 | @ TEX | 84 | L 5-13 | 36-48 | 5 | 31,953 | Jeremy Guthrie | Alexi Ogando | Alexi Ogando | Jeremy Guthrie | | 342 | 422 | -80 |
| 2011-07-07 | @ BOS | 85 | L 4-10 | 36-49 | 5 | 37,981 | Jake Arrieta | Andrew Miller | Andrew Miller | Jake Arrieta | | 346 | 432 | -86 |
| 2011-07-08 | @ BOS | 86 | L 3-10 | 36-50 | 5 | 37,729 | Zachary Britton | Josh Beckett | Josh Beckett | Zachary Britton | | 349 | 442 | -93 |
| 2011-07-09 | @ BOS | 87 | L 0-4 | 36-51 | 5 | 38,205 | Alfredo Simon | John Lackey | John Lackey | Alfredo Simon | | 349 | 446 | -97 |
| 2011-07-10 | @ BOS | 88 | L 6-8 | 36-52 | 5 | 37,688 | Mitch Atkins | Kyle Weiland | Alfredo Aceves | Jeremy Guthrie | Jonathan Papelbon | 355 | 454 | -99 |
| 2011-07-14 | vs CLE | 89 | L 4-8 | 36-53 | 5 | 22,780 | Jeremy Guthrie | Justin Masterson | Justin Masterson | Jeremy Guthrie | | 359 | 462 | -103 |
| 2011-07-15 | vs CLE | 90 | L 5-6 | 36-54 | 5 | 27,372 | Jake Arrieta | Josh Tomlin | Josh Tomlin | Jim Johnson | Chris Perez | 364 | 468 | -104 |
| 2011-07-16 | vs CLE | 91 | W 6-5 | 37-54 | 5 | 24,835 | Alfredo Simon | Carlos Carrasco | Alfredo Simon | Carlos Carrasco | Mike Gonzalez | 370 | 473 | -103 |
| 2011-07-17 | vs CLE | 92 | W 8-3 | 38-54 | 5 | 17,754 | Mitch Atkins | Jeanmar Gomez | Mark Hendrickson | Jeanmar Gomez | | 378 | 476 | -98 |
| 2011-07-18 | vs BOS | 93 | L 10-15 | 38-55 | 5 | 27,924 | Brad Bergesen | Tim Wakefield | Dan Wheeler | Mike Gonzalez | | 388 | 491 | -103 |
| 2011-07-19 | vs BOS | 94 | W 6-2 | 39-55 | 5 | 32,314 | Jeremy Guthrie | Kyle Weiland | Jeremy Guthrie | Kyle Weiland | Jim Johnson | 394 | 493 | -99 |
| 2011-07-20 | vs BOS | 95 | L 0-4 | 39-56 | 5 | 35,174 | Jake Arrieta | Andrew Miller | Andrew Miller | Jake Arrieta | | 394 | 497 | -103 |
| 2011-07-22 | vs ANA | 96 | L 1-6 | 39-57 | 5 | 24,823 | Alfredo Simon | Ervin Santana | Ervin Santana | Alfredo Simon | Hisanori Takahashi | 395 | 503 | -108 |
| 2011-07-23 | vs ANA | 97 | W 3-2 | 40-57 | 5 | 20,311 | Brad Bergesen | Joel Pineiro | Brad Bergesen | Joel Pineiro | Kevin Gregg | 398 | 505 | -107 |
| 2011-07-24 | vs ANA | 98 | L 3-9 | 40-58 | 5 | 15,676 | Jeremy Guthrie | Tyler Chatwood | Tyler Chatwood | Jeremy Guthrie | | 401 | 514 | -113 |
| 2011-07-26 | @ TOR | 99 | W 12-4 | 41-58 | 5 | 17,477 | Jake Arrieta | Brandon Morrow | Jake Arrieta | Brandon Morrow | | 413 | 518 | -105 |
| 2011-07-27 | @ TOR | 100 | L 0-3 | 41-59 | 5 | 16,861 | Alfredo Simon | Ricky Romero | Ricky Romero | Alfredo Simon | Jon Rauch | 413 | 521 | -108 |
| 2011-07-28 | @ TOR | 101 | L 5-8 | 41-60 | 5 | 16,152 | Brad Bergesen | Carlos Villanueva | Carlos Villanueva | Brad Bergesen | | 418 | 529 | -111 |
| 2011-07-29 | @ NYA | 102 | W 4-2 | 42-60 | 5 | 46,499 | Jeremy Guthrie | A.J. Burnett | Jeremy Guthrie | A.J. Burnett | Kevin Gregg | 422 | 531 | -109 |
| 2011-07-30 | @ NYA | 103 | L 3-8 | 42-62 | 7 | 46,469 | Chris Tillman | Bartolo Colon | Bartolo Colon | Chris Tillman | | 425 | 539 | -114 |
| 2011-07-30 | @ NYA | 104 | L 3-17 | 42-62 | 7 | 43,190 | Zachary Britton | Ivan Nova | Ivan Nova | Zachary Britton | | 428 | 556 | -128 |
| 2011-07-31 | @ NYA | 105 | L 2-4 | 42-63 | 5 | 46,913 | Jake Arrieta | Freddy Garcia | Freddy Garcia | Jake Arrieta | Mariano Rivera | 430 | 560 | -130 |
| 2011-08-02 | @ KCA | 106 | W 8-2 | 43-63 | 5 | 17,116 | Alfredo Simon | Bruce Chen | Alfredo Simon | Bruce Chen | | 438 | 562 | -124 |
| 2011-08-03 | @ KCA | 107 | L 2-6 | 43-64 | 5 | 14,187 | Jeremy Guthrie | Luke Hochevar | Luke Hochevar | Jeremy Guthrie | Greg Holland | 440 | 568 | -128 |
| 2011-08-04 | @ KCA | 108 | L 4-9 | 43-65 | 5 | 12,161 | Zachary Britton | Jeff Francis | Blake Wood | Zachary Britton | | 444 | 577 | -133 |
| 2011-08-05 | vs TOR | 109 | L 4-5 | 43-66 | 5 | 18,770 | Tommy Hunter | Brad Mills | Brad Mills | Tommy Hunter | Jon Rauch | 448 | 582 | -134 |
| 2011-08-06 | vs TOR | 110 | W 6-2 | 44-66 | 5 | 19,396 | Chris Tillman | Brandon Morrow | Chris Tillman | Brandon Morrow | | 454 | 584 | -130 |
| 2011-08-07 | vs TOR | 111 | L 2-7 | 44-67 | 5 | 13,824 | Alfredo Simon | Ricky Romero | Ricky Romero | Alfredo Simon | | 456 | 591 | -135 |
| 2011-08-08 | vs CHA | 112 | L 6-7 | 44-68 | 5 | 17,498 | Jeremy Guthrie | John Danks | Jesse Crain | Jim Johnson | Sergio Santos | 462 | 598 | -136 |
| 2011-08-09 | vs CHA | 113 | L 3-4 | 44-69 | 5 | 14,177 | Jo-Jo Reyes | Gavin Floyd | Gavin Floyd | Jo-Jo Reyes | Sergio Santos | 465 | 602 | -137 |
| 2011-08-10 | vs CHA | 114 | W 6-4 | 45-69 | 5 | 18,747 | Tommy Hunter | Philip Humber | Mike Gonzalez | Jason Frasor | | 471 | 606 | -135 |
| 2011-08-11 | vs CHA | 115 | L 3-6 | 45-70 | 5 | 21,040 | Chris Tillman | Mark Buehrle | Mark Buehrle | Chris Tillman | Sergio Santos | 474 | 612 | -138 |
| 2011-08-12 | vs DET | 116 | L 4-5 | 45-71 | 5 | 21,465 | Alfredo Simon | Brad Penny | Brad Penny | Troy Patton | Jose Valverde | 478 | 617 | -139 |
| 2011-08-13 | vs DET | 117 | L 5-6 | 45-72 | 5 | 24,114 | Jeremy Guthrie | Max Scherzer | Max Scherzer | Jeremy Guthrie | Jose Valverde | 483 | 623 | -140 |
| 2011-08-14 | vs DET | 118 | W 8-5 | 46-72 | 5 | 18,348 | Jo-Jo Reyes | Doug Fister | Jo-Jo Reyes | Doug Fister | Jim Johnson | 491 | 628 | -137 |
| 2011-08-15 | @ OAK | 119 | W 6-2 | 47-72 | 5 | 10,122 | Tommy Hunter | Gio Gonzalez | Tommy Hunter | Gio Gonzalez | | 497 | 630 | -133 |
| 2011-08-16 | @ OAK | 120 | L 4-8 | 47-73 | 7 | 12,325 | Brian Matusz | Guillermo Moscoso | Guillermo Moscoso | Brian Matusz | | 501 | 638 | -137 |
| 2011-08-17 | @ OAK | 121 | L 5-6 | 47-74 | 5 | 20,448 | Alfredo Simon | Brandon McCarthy | Brandon McCarthy | Alfredo Simon | Andrew Bailey | 506 | 644 | -138 |
| 2011-08-19 | @ ANA | 122 | L 3-8 | 47-75 | 5 | 38,156 | Jo-Jo Reyes | Dan Haren | Dan Haren | Jo-Jo Reyes | | 509 | 652 | -143 |
| 2011-08-20 | @ ANA | 123 | L 8-9 | 47-76 | 5 | 43,201 | Tommy Hunter | Joel Pineiro | Fernando Rodney | Kevin Gregg | | 517 | 661 | -144 |
| 2011-08-21 | @ ANA | 124 | L 1-7 | 47-77 | 5 | 37,148 | Brian Matusz | Jerome Williams | Jerome Williams | Brian Matusz | | 518 | 668 | -150 |
| 2011-08-22 | @ MIN | 125 | W 4-1 | 48-77 | 5 | 38,986 | Zachary Britton | Carl Pavano | Zachary Britton | Carl Pavano | Kevin Gregg | 522 | 669 | -147 |
| 2011-08-23 | @ MIN | 126 | W 8-1 | 49-77 | 5 | 38,786 | Alfredo Simon | Brian Duensing | Alfredo Simon | Brian Duensing | | 530 | 670 | -140 |
| 2011-08-24 | @ MIN | 127 | W 6-1 | 50-77 | 5 | 37,778 | Jeremy Guthrie | Kevin Slowey | Jeremy Guthrie | Kevin Slowey | | 536 | 671 | -135 |
| 2011-08-25 | @ MIN | 128 | W 6-1 | 51-77 | 5 | 38,406 | Jo-Jo Reyes | Francisco Liriano | Jo-Jo Reyes | Anthony Swarzak | | 542 | 672 | -130 |
| 2011-08-26 | vs NYA | 129 | W 12-5 | 52-77 | 5 | 32,762 | Tommy Hunter | A.J. Burnett | Tommy Hunter | A.J. Burnett | | 554 | 677 | -123 |
| 2011-08-28 | vs NYA | 130 | W 2-0 | 53-78 | 7 | 28,751 | Zachary Britton | Bartolo Colon | Zachary Britton | Bartolo Colon | Kevin Gregg | 556 | 677 | -121 |
| 2011-08-28 | vs NYA | 131 | L 3-8 | 53-78 | 7 | 37,528 | Brian Matusz | Ivan Nova | Ivan Nova | Brian Matusz | | 559 | 685 | -126 |
| 2011-08-29 | vs NYA | 132 | L 2-3 | 53-79 | 5 | 18,223 | Alfredo Simon | Freddy Garcia | Freddy Garcia | Alfredo Simon | Mariano Rivera | 561 | 688 | -127 |
| 2011-08-30 | vs TOR | 133 | W 6-5 | 54-79 | 5 | 10,756 | Jeremy Guthrie | Brett Cecil | Willie Eyre | Brian Tallet | | 567 | 693 | -126 |
| 2011-08-31 | vs TOR | 134 | L 0-13 | 54-80 | 5 | 14,211 | Jo-Jo Reyes | Henderson Alvarez | Henderson Alvarez | Jo-Jo Reyes | | 567 | 706 | -139 |
| 2011-09-01 | vs TOR | 135 | L 6-8 | 54-81 | 5 | 11,617 | Tommy Hunter | Luis Perez | Shawn Camp | Willie Eyre | Frank Francisco | 573 | 714 | -141 |
| 2011-09-02 | @ TBA | 136 | W 3-2 | 55-81 | 5 | 11,955 | Zachary Britton | David Price | Zachary Britton | David Price | Kevin Gregg | 576 | 716 | -140 |
| 2011-09-03 | @ TBA | 137 | L 3-6 | 55-82 | 5 | 14,223 | Alfredo Simon | Wade Davis | Wade Davis | Alfredo Simon | Kyle Farnsworth | 579 | 722 | -143 |
| 2011-09-04 | @ TBA | 138 | L 1-8 | 55-83 | 5 | 15,790 | Jeremy Guthrie | Jeremy Hellickson | Jeremy Hellickson | Jeremy Guthrie | | 580 | 730 | -150 |
| 2011-09-05 | @ NYA | 139 | L 10-11 | 55-84 | 5 | 45,069 | Brian Matusz | Freddy Garcia | Aaron Laffey | Jim Johnson | Mariano Rivera | 590 | 741 | -151 |
| 2011-09-06 | @ NYA | 140 | L 3-5 | 55-85 | 5 | 44,573 | Tommy Hunter | Phil Hughes | Cory Wade | Tommy Hunter | Mariano Rivera | 593 | 746 | -153 |
| 2011-09-07 | @ NYA | 141 | W 5-4 | 56-85 | 5 | 40,104 | Zachary Britton | A.J. Burnett | Pedro Strop | Hector Noesi | Jim Johnson | 598 | 750 | -152 |
| 2011-09-08 | vs NYA | 142 | W 5-4 | 57-85 | 5 | 33,841 | Alfredo Simon | Ivan Nova | Clay Rapada | Scott Proctor | | 603 | 754 | -151 |
| 2011-09-09 | @ TOR | 143 | W 2-0 | 58-85 | 5 | 13,918 | Jeremy Guthrie | Brett Cecil | Jeremy Guthrie | Brett Cecil | Jim Johnson | 605 | 754 | -149 |
| 2011-09-10 | @ TOR | 144 | L 4-5 | 58-86 | 5 | 17,742 | Rick Vanden Hurk | Henderson Alvarez | Jesse Litsch | Kevin Gregg | | 609 | 759 | -150 |
| 2011-09-11 | @ TOR | 145 | L 5-6 | 58-87 | 5 | 14,235 | Tommy Hunter | Dustin McGowan | Joel Carreno | Tommy Hunter | Frank Francisco | 614 | 765 | -151 |
| 2011-09-12 | vs TBA | 146 | L 2-5 | 58-88 | 5 | 11,924 | Zachary Britton | Jeff Niemann | Jeff Niemann | Zachary Britton | Joel Peralta | 616 | 770 | -154 |
| 2011-09-13 | vs TBA | 147 | W 4-2 | 59-88 | 5 | 13,262 | Alfredo Simon | David Price | Troy Patton | J.P. Howell | Jim Johnson | 620 | 772 | -152 |
| 2011-09-14 | vs TBA | 148 | W 6-2 | 60-88 | 5 | 14,669 | Jeremy Guthrie | Wade Davis | Jeremy Guthrie | Wade Davis | Jim Johnson | 626 | 774 | -148 |
| 2011-09-16 | vs ANA | 149 | W 8-3 | 61-88 | 5 | 24,022 | Tommy Hunter | Dan Haren | Tommy Hunter | Dan Haren | | 634 | 777 | -143 |
| 2011-09-17 | vs ANA | 150 | W 6-2 | 62-88 | 5 | 31,099 | Zachary Britton | Ervin Santana | Zachary Britton | Ervin Santana | | 640 | 779 | -139 |
| 2011-09-18 | vs ANA | 151 | L 2-11 | 62-89 | 5 | 27,471 | Alfredo Simon | Jered Weaver | Jered Weaver | Alfredo Simon | | 642 | 790 | -148 |
| 2011-09-19 | @ BOS | 152 | W 6-5 | 63-90 | 7 | 37,885 | Jeremy Guthrie | Kyle Weiland | Jeremy Guthrie | Kyle Weiland | Jim Johnson | 648 | 795 | -147 |
| 2011-09-19 | @ BOS | 153 | L 9-18 | 63-90 | 7 | 37,261 | Brian Matusz | John Lackey | Scott Atchison | Brian Matusz | | 657 | 813 | -156 |
| 2011-09-20 | @ BOS | 154 | W 7-5 | 64-90 | 5 | 37,414 | Rick Vanden Hurk | Erik Bedard | Willie Eyre | Daniel Bard | Jim Johnson | 664 | 818 | -154 |
| 2011-09-21 | @ BOS | 155 | W 6-4 | 65-90 | 7 | 38,004 | Tommy Hunter | Josh Beckett | Clay Rapada | Josh Beckett | Jim Johnson | 670 | 822 | -152 |
| 2011-09-22 | @ DET | 156 | W 6-5 | 66-90 | 5 | 27,847 | Zachary Britton | Jacob Turner | Zachary Britton | David Pauley | Kevin Gregg | 676 | 827 | -151 |
| 2011-09-23 | @ DET | 157 | L 3-4 | 66-91 | 5 | 38,623 | Alfredo Simon | Rick Porcello | Ryan Perry | Willie Eyre | | 679 | 831 | -152 |
| 2011-09-24 | @ DET | 158 | W 6-5 | 67-91 | 5 | 44,846 | Jeremy Guthrie | Justin Verlander | Pedro Strop | Daniel Schlereth | Kevin Gregg | 685 | 836 | -151 |
| 2011-09-25 | @ DET | 159 | L 6-10 | 67-92 | 7 | 41,051 | Brian Matusz | Brad Penny | Brad Penny | Brian Matusz | | 691 | 846 | -155 |
| 2011-09-26 | vs BOS | 160 | W 6-3 | 68-92 | 5 | 21,786 | Tommy Hunter | Josh Beckett | Troy Patton | Josh Beckett | | 697 | 849 | -152 |
| 2011-09-27 | vs BOS | 161 | L 7-8 | 68-93 | 5 | 22,123 | Zachary Britton | Erik Bedard | Alfredo Aceves | Zachary Britton | Jonathan Papelbon | 704 | 857 | -153 |
| 2011-09-28 | vs BOS | 162 | W 4-3 | 69-93 | 5 | 29,749 | Alfredo Simon | Jon Lester | Jim Johnson | Jonathan Papelbon | | 708 | 860 | -152 |