| 2011-03-31 | vs ATL | 1 | L 0-2 | 0-1 | 2 | 39,055 | Livan Hernandez | Derek Lowe | Derek Lowe | Livan Hernandez | Craig Kimbrel | 0 | 2 | -2 |
| 2011-04-02 | vs ATL | 2 | W 6-3 | 1-1 | 5 | 21,941 | John Lannan | Tommy Hanson | John Lannan | Tommy Hanson | Sean Burnett | 6 | 5 | 1 |
| 2011-04-03 | vs ATL | 3 | L 2-11 | 1-2 | 5 | 22,210 | Jordan Zimmermann | Tim Hudson | Tim Hudson | Jordan Zimmermann | | 8 | 16 | -8 |
| 2011-04-05 | @ FLO | 4 | L 2-3 | 1-3 | 5 | 10,482 | Jason Marquis | Anibal Sanchez | Edward Mujica | Drew Storen | | 10 | 19 | -9 |
| 2011-04-06 | @ FLO | 5 | L 4-7 | 1-4 | 5 | 13,825 | Livan Hernandez | Chris Volstad | Brian Sanches | Chad Gaudin | Leo Nunez | 14 | 26 | -12 |
| 2011-04-07 | @ FLO | 6 | W 5-3 | 2-4 | 5 | 10,696 | John Lannan | Josh Johnson | Todd Coffey | Edward Mujica | Sean Burnett | 19 | 29 | -10 |
| 2011-04-08 | @ NYN | 7 | W 6-2 | 3-4 | 5 | 41,075 | Jordan Zimmermann | R.A. Dickey | Jordan Zimmermann | R.A. Dickey | | 25 | 31 | -6 |
| 2011-04-09 | @ NYN | 8 | L 4-8 | 3-5 | 5 | 31,696 | Tom Gorzelanny | Chris Capuano | Chris Capuano | Tom Gorzelanny | Francisco Rodriguez | 29 | 39 | -10 |
| 2011-04-10 | @ NYN | 9 | W 7-3 | 4-5 | 4 | 35,157 | Jason Marquis | Chris Young | Drew Storen | Blaine Boyer | | 36 | 42 | -6 |
| 2011-04-12 | vs PHI | 10 | W 7-4 | 5-5 | 3 | 13,413 | Livan Hernandez | Joe Blanton | Livan Hernandez | Joe Blanton | Sean Burnett | 43 | 46 | -3 |
| 2011-04-13 | vs PHI | 11 | L 2-3 | 5-6 | 3 | 16,914 | John Lannan | Roy Halladay | Roy Halladay | John Lannan | | 45 | 49 | -4 |
| 2011-04-14 | vs PHI | 12 | L 0-4 | 5-7 | 3 | 24,875 | Jordan Zimmermann | Cliff Lee | Cliff Lee | Jordan Zimmermann | | 45 | 53 | -8 |
| 2011-04-15 | vs MIL | 13 | W 4-3 | 6-7 | 3 | 17,217 | Tom Gorzelanny | Chris Narveson | Chad Gaudin | Zach Braddock | | 49 | 56 | -7 |
| 2011-04-17 | vs MIL | 14 | W 8-4 | 7-7 | 4 | 0 | Jason Marquis | Yovani Gallardo | Jason Marquis | Yovani Gallardo | | 57 | 60 | -3 |
| 2011-04-17 | vs MIL | 15 | W 5-1 | 7-7 | 4 | 23,047 | Livan Hernandez | Marco Estrada | Livan Hernandez | Kameron Loe | Drew Storen | 62 | 61 | 1 |
| 2011-04-20 | @ SLN | 16 | W 8-6 | 9-8 | 4 | 32,340 | John Lannan | Jake Westbrook | John Lannan | Jake Westbrook | Drew Storen | 70 | 67 | 3 |
| 2011-04-20 | @ SLN | 17 | L 3-5 | 9-8 | 4 | 33,714 | Jordan Zimmermann | Jaime Garcia | Jaime Garcia | Jordan Zimmermann | Mitchell Boggs | 73 | 72 | 1 |
| 2011-04-21 | @ SLN | 18 | L 0-5 | 9-9 | 3 | 36,160 | Tom Gorzelanny | Kyle Lohse | Kyle Lohse | Tom Gorzelanny | | 73 | 77 | -4 |
| 2011-04-23 | @ PIT | 19 | L 2-7 | 9-10 | 3 | 18,262 | Livan Hernandez | Jeff Karstens | Jeff Karstens | Livan Hernandez | | 75 | 84 | -9 |
| 2011-04-24 | @ PIT | 20 | W 6-3 | 10-10 | 3 | 9,520 | Jason Marquis | Kevin Correia | Jason Marquis | Kevin Correia | Drew Storen | 81 | 87 | -6 |
| 2011-04-25 | @ PIT | 21 | L 2-4 | 10-11 | 3 | 12,457 | John Lannan | Paul Maholm | Paul Maholm | John Lannan | Joel Hanrahan | 83 | 91 | -8 |
| 2011-04-26 | vs NYN | 22 | L 4-6 | 10-12 | 4 | 14,603 | Jordan Zimmermann | Chris Young | Ryota Igarashi | Jordan Zimmermann | Francisco Rodriguez | 87 | 97 | -10 |
| 2011-04-27 | vs NYN | 23 | L 3-6 | 10-13 | 5 | 13,568 | Tom Gorzelanny | R.A. Dickey | Pedro Beato | Sean Burnett | Francisco Rodriguez | 90 | 103 | -13 |
| 2011-04-28 | vs NYN | 24 | W 4-3 | 11-13 | 4 | 15,142 | Livan Hernandez | Chris Capuano | Livan Hernandez | Chris Capuano | Drew Storen | 94 | 106 | -12 |
| 2011-04-29 | vs SFN | 25 | W 3-0 | 12-13 | 4 | 21,399 | Jason Marquis | Tim Lincecum | Jason Marquis | Tim Lincecum | | 97 | 106 | -9 |
| 2011-04-30 | vs SFN | 26 | L 1-2 | 12-14 | 4 | 28,766 | John Lannan | Jonathan Sanchez | Guillermo Mota | John Lannan | Brian Wilson | 98 | 108 | -10 |
| 2011-05-01 | vs SFN | 27 | W 5-2 | 13-14 | 4 | 21,611 | Jordan Zimmermann | Matt Cain | Jordan Zimmermann | Matt Cain | Drew Storen | 103 | 110 | -7 |
| 2011-05-02 | vs SFN | 28 | W 2-0 | 14-14 | 4 | 15,342 | Tom Gorzelanny | Madison Bumgarner | Tom Gorzelanny | Madison Bumgarner | Drew Storen | 105 | 110 | -5 |
| 2011-05-03 | @ PHI | 29 | L 1-4 | 14-15 | 4 | 45,695 | Livan Hernandez | Cole Hamels | Cole Hamels | Livan Hernandez | | 106 | 114 | -8 |
| 2011-05-04 | @ PHI | 30 | L 4-7 | 14-16 | 5 | 44,123 | Jason Marquis | Vance Worley | Vance Worley | Jason Marquis | | 110 | 121 | -11 |
| 2011-05-05 | @ PHI | 31 | L 3-7 | 14-17 | 4 | 45,316 | John Lannan | Roy Halladay | Roy Halladay | John Lannan | | 113 | 128 | -15 |
| 2011-05-06 | @ FLO | 32 | W 3-2 | 15-17 | 4 | 15,325 | Jordan Zimmermann | Ricky Nolasco | Drew Storen | Michael Dunn | Sean Burnett | 116 | 130 | -14 |
| 2011-05-07 | @ FLO | 33 | W 5-2 | 16-17 | 4 | 17,409 | Tom Gorzelanny | Chris Volstad | Tom Gorzelanny | Chris Volstad | Drew Storen | 121 | 132 | -11 |
| 2011-05-08 | @ FLO | 34 | L 0-8 | 16-18 | 4 | 10,523 | Livan Hernandez | Anibal Sanchez | Anibal Sanchez | Livan Hernandez | | 121 | 140 | -19 |
| 2011-05-10 | @ ATL | 35 | W 7-6 | 17-18 | 4 | 16,143 | Jason Marquis | Tim Hudson | Jason Marquis | Tim Hudson | Drew Storen | 128 | 146 | -18 |
| 2011-05-11 | @ ATL | 36 | W 7-3 | 18-18 | 4 | 16,692 | John Lannan | Tommy Hanson | Drew Storen | Scott Linebrink | | 135 | 149 | -14 |
| 2011-05-12 | @ ATL | 37 | L 5-6 | 18-19 | 4 | 19,758 | Jordan Zimmermann | Derek Lowe | Craig Kimbrel | Doug Slaten | | 140 | 155 | -15 |
| 2011-05-13 | vs FLO | 38 | L 5-6 | 18-20 | 5 | 19,503 | Tom Gorzelanny | Chris Volstad | Edward Mujica | Brian Broderick | Leo Nunez | 145 | 161 | -16 |
| 2011-05-14 | vs FLO | 39 | L 0-1 | 18-21 | 5 | 22,497 | Livan Hernandez | Anibal Sanchez | Anibal Sanchez | Livan Hernandez | Leo Nunez | 145 | 162 | -17 |
| 2011-05-15 | vs FLO | 40 | W 8-4 | 19-21 | 5 | 18,356 | Jason Marquis | Javier Vazquez | Jason Marquis | Javier Vazquez | | 153 | 166 | -13 |
| 2011-05-16 | vs PIT | 41 | W 4-2 | 20-21 | 4 | 21,960 | John Lannan | Paul Maholm | Cole Kimball | Paul Maholm | Drew Storen | 157 | 168 | -11 |
| 2011-05-18 | @ NYN | 42 | L 0-3 | 20-22 | 5 | 24,527 | Tom Gorzelanny | Jonathon Niese | Jonathon Niese | Tom Gorzelanny | Francisco Rodriguez | 157 | 171 | -14 |
| 2011-05-19 | @ NYN | 43 | L 0-1 | 20-23 | 5 | 26,835 | Livan Hernandez | Dillon Gee | Dillon Gee | Livan Hernandez | Francisco Rodriguez | 157 | 172 | -15 |
| 2011-05-20 | @ BAL | 44 | W 17-5 | 21-23 | 5 | 24,442 | Jason Marquis | Jake Arrieta | Henry Rodriguez | Jake Arrieta | | 174 | 177 | -3 |
| 2011-05-21 | @ BAL | 45 | L 3-8 | 21-24 | 5 | 33,107 | John Lannan | Jeremy Guthrie | Jeremy Guthrie | John Lannan | | 177 | 185 | -8 |
| 2011-05-22 | @ BAL | 46 | L 1-2 | 21-25 | 5 | 33,626 | Jordan Zimmermann | Chris Tillman | Jim Johnson | Jordan Zimmermann | Kevin Gregg | 178 | 187 | -9 |
| 2011-05-23 | @ MIL | 47 | L 3-11 | 21-26 | 5 | 22,906 | Tom Gorzelanny | Yovani Gallardo | Yovani Gallardo | Tom Gorzelanny | | 181 | 198 | -17 |
| 2011-05-24 | @ MIL | 48 | L 6-7 | 21-27 | 5 | 24,722 | Livan Hernandez | Chris Narveson | Mike McClendon | Henry Rodriguez | John Axford | 187 | 205 | -18 |
| 2011-05-25 | @ MIL | 49 | L 4-6 | 21-28 | 5 | 34,419 | Jason Marquis | Zack Greinke | Zack Greinke | Jason Marquis | Kameron Loe | 191 | 211 | -20 |
| 2011-05-27 | vs SDN | 50 | W 2-1 | 22-28 | 5 | 21,024 | John Lannan | Clayton Richard | Drew Storen | Mike Adams | | 193 | 212 | -19 |
| 2011-05-28 | vs SDN | 51 | L 1-2 | 22-29 | 5 | 19,159 | Jordan Zimmermann | Tim Stauffer | Tim Stauffer | Jordan Zimmermann | Heath Bell | 194 | 214 | -20 |
| 2011-05-29 | vs SDN | 52 | L 4-5 | 22-30 | 5 | 23,169 | Yuniesky Maya | Dustin Moseley | Luke Gregerson | Drew Storen | Heath Bell | 198 | 219 | -21 |
| 2011-05-30 | vs PHI | 53 | L 4-5 | 22-31 | 5 | 34,789 | Livan Hernandez | Roy Halladay | Roy Halladay | Sean Burnett | Ryan Madson | 202 | 224 | -22 |
| 2011-05-31 | vs PHI | 54 | W 10-2 | 23-31 | 5 | 21,017 | Jason Marquis | Cliff Lee | Jason Marquis | Cliff Lee | | 212 | 226 | -14 |
| 2011-06-01 | vs PHI | 55 | W 2-1 | 24-31 | 5 | 24,495 | John Lannan | Roy Oswalt | John Lannan | Roy Oswalt | Drew Storen | 214 | 227 | -13 |
| 2011-06-02 | @ ARI | 56 | W 6-1 | 25-31 | 5 | 17,810 | Jordan Zimmermann | Zach Duke | Jordan Zimmermann | Zach Duke | Drew Storen | 220 | 228 | -8 |
| 2011-06-03 | @ ARI | 57 | L 0-4 | 25-32 | 5 | 20,332 | Yuniesky Maya | Josh Collmenter | Josh Collmenter | Yuniesky Maya | | 220 | 232 | -12 |
| 2011-06-04 | @ ARI | 58 | L 0-2 | 25-33 | 5 | 26,199 | Livan Hernandez | Joe Saunders | Joe Saunders | Livan Hernandez | J.J. Putz | 220 | 234 | -14 |
| 2011-06-05 | @ ARI | 59 | W 9-4 | 26-33 | 5 | 23,129 | Jason Marquis | Ian Kennedy | Sean Burnett | Joe Paterson | | 229 | 238 | -9 |
| 2011-06-06 | @ SFN | 60 | L 4-5 | 26-34 | 5 | 41,180 | John Lannan | Tim Lincecum | Javier Lopez | Craig Stammen | | 233 | 243 | -10 |
| 2011-06-07 | @ SFN | 61 | W 2-1 | 27-34 | 5 | 41,786 | Jordan Zimmermann | Jonathan Sanchez | Jordan Zimmermann | Jonathan Sanchez | Drew Storen | 235 | 244 | -9 |
| 2011-06-08 | @ SFN | 62 | L 1-3 | 27-35 | 5 | 41,738 | Yuniesky Maya | Matt Cain | Matt Cain | Sean Burnett | | 236 | 247 | -11 |
| 2011-06-09 | @ SDN | 63 | L 3-7 | 27-36 | 5 | 16,464 | Livan Hernandez | Aaron Harang | Aaron Harang | Livan Hernandez | | 239 | 254 | -15 |
| 2011-06-10 | @ SDN | 64 | W 2-1 | 28-36 | 5 | 23,211 | Jason Marquis | Mat Latos | Jason Marquis | Mat Latos | Drew Storen | 241 | 255 | -14 |
| 2011-06-11 | @ SDN | 65 | W 2-1 | 29-36 | 5 | 25,027 | John Lannan | Clayton Richard | John Lannan | Clayton Richard | Drew Storen | 243 | 256 | -13 |
| 2011-06-12 | @ SDN | 66 | W 2-0 | 30-36 | 5 | 20,185 | Jordan Zimmermann | Tim Stauffer | Todd Coffey | Heath Bell | Drew Storen | 245 | 256 | -11 |
| 2011-06-14 | vs SLN | 67 | W 8-6 | 31-36 | 5 | 26,739 | Yuniesky Maya | Jaime Garcia | Henry Rodriguez | Miguel Batista | Drew Storen | 253 | 262 | -9 |
| 2011-06-15 | vs SLN | 68 | W 10-0 | 32-36 | 7 | 27,130 | Livan Hernandez | Kyle McClellan | Livan Hernandez | Kyle McClellan | | 263 | 262 | 1 |
| 2011-06-16 | vs SLN | 69 | W 7-4 | 33-36 | 4 | 19,662 | John Lannan | Kyle Lohse | Sean Burnett | Fernando Salas | | 270 | 266 | 4 |
| 2011-06-17 | vs BAL | 70 | W 8-4 | 34-36 | 4 | 35,562 | Jason Marquis | Zachary Britton | Sean Burnett | Jeremy Accardo | | 278 | 270 | 8 |
| 2011-06-18 | vs BAL | 71 | W 4-2 | 35-36 | 4 | 36,614 | Jordan Zimmermann | Brian Matusz | Jordan Zimmermann | Brian Matusz | Drew Storen | 282 | 272 | 10 |
| 2011-06-19 | vs BAL | 72 | L 4-7 | 35-37 | 4 | 35,439 | Tom Gorzelanny | Chris Jakubauskas | Chris Jakubauskas | Tom Gorzelanny | | 286 | 279 | 7 |
| 2011-06-21 | vs SEA | 73 | W 6-5 | 36-37 | 3 | 21,502 | Livan Hernandez | Doug Fister | Todd Coffey | David Pauley | | 292 | 284 | 8 |
| 2011-06-22 | vs SEA | 74 | W 2-1 | 37-37 | 3 | 21,367 | John Lannan | Erik Bedard | John Lannan | Erik Bedard | Drew Storen | 294 | 285 | 9 |
| 2011-06-23 | vs SEA | 75 | W 1-0 | 38-37 | 3 | 21,161 | Jason Marquis | Michael Pineda | Tyler Clippard | Chris Ray | | 295 | 285 | 10 |
| 2011-06-24 | @ CHA | 76 | W 9-5 | 39-37 | 3 | 23,856 | Jordan Zimmermann | Edwin Jackson | Collin Balester | Matt Thornton | | 304 | 290 | 14 |
| 2011-06-25 | @ CHA | 77 | L 0-3 | 39-38 | 3 | 23,008 | Tom Gorzelanny | John Danks | Jake Peavy | Tom Gorzelanny | Sergio Santos | 304 | 293 | 11 |
| 2011-06-26 | @ CHA | 78 | W 2-1 | 40-38 | 3 | 24,057 | Livan Hernandez | Philip Humber | Livan Hernandez | Philip Humber | Drew Storen | 306 | 294 | 12 |
| 2011-06-27 | @ ANA | 79 | L 3-4 | 40-39 | 3 | 35,032 | John Lannan | Ervin Santana | Scott Downs | Sean Burnett | | 309 | 298 | 11 |
| 2011-06-28 | @ ANA | 80 | L 5-11 | 40-40 | 4 | 41,029 | Jason Marquis | Joel Pineiro | Hisanori Takahashi | Collin Balester | | 314 | 309 | 5 |
| 2011-06-29 | @ ANA | 81 | L 0-1 | 40-41 | 4 | 35,257 | Jordan Zimmermann | Dan Haren | Dan Haren | Jordan Zimmermann | Jordan Walden | 314 | 310 | 4 |
| 2011-07-01 | vs PIT | 82 | W 2-1 | 41-41 | 4 | 22,399 | Tom Gorzelanny | Charlie Morton | Drew Storen | Tim Wood | | 316 | 311 | 5 |
| 2011-07-02 | vs PIT | 83 | L 3-5 | 41-42 | 5 | 0 | Livan Hernandez | James McDonald | Jose Veras | Sean Burnett | Joel Hanrahan | 319 | 316 | 3 |
| 2011-07-02 | vs PIT | 84 | W 4-3 | 41-42 | 5 | 39,638 | John Lannan | Brad Lincoln | Ryan Mattheus | Tony Watson | Drew Storen | 323 | 319 | 4 |
| 2011-07-03 | vs PIT | 85 | L 2-10 | 42-43 | 4 | 23,522 | Jason Marquis | Kevin Correia | Kevin Correia | Jason Marquis | | 325 | 329 | -4 |
| 2011-07-04 | vs CHN | 86 | W 5-4 | 43-43 | 4 | 32,937 | Jordan Zimmermann | Casey Coleman | Henry Rodriguez | Marcos Mateo | | 330 | 333 | -3 |
| 2011-07-05 | vs CHN | 87 | W 3-2 | 44-43 | 4 | 19,181 | Ross Detwiler | Ramon Ortiz | Ross Detwiler | Ramon Ortiz | Drew Storen | 333 | 335 | -2 |
| 2011-07-06 | vs CHN | 88 | W 5-4 | 45-43 | 4 | 19,631 | Tom Gorzelanny | Randy Wells | Ryan Mattheus | Kerry Wood | Drew Storen | 338 | 339 | -1 |
| 2011-07-07 | vs CHN | 89 | L 9-10 | 45-44 | 4 | 22,016 | Livan Hernandez | Matt Garza | Sean Marshall | Henry Rodriguez | Carlos Marmol | 347 | 349 | -2 |
| 2011-07-08 | vs COL | 90 | L 2-3 | 45-45 | 4 | 19,046 | John Lannan | Jason Hammel | Jason Hammel | John Lannan | Huston Street | 349 | 352 | -3 |
| 2011-07-09 | vs COL | 91 | L 1-2 | 45-46 | 4 | 29,441 | Jason Marquis | Ubaldo Jimenez | Ubaldo Jimenez | Jason Marquis | Huston Street | 350 | 354 | -4 |
| 2011-07-10 | vs COL | 92 | W 2-0 | 46-46 | 4 | 21,186 | Jordan Zimmermann | Jhoulis Chacin | Jordan Zimmermann | Jhoulis Chacin | Drew Storen | 352 | 354 | -2 |
| 2011-07-15 | @ ATL | 93 | L 1-11 | 46-47 | 4 | 34,106 | Livan Hernandez | Tim Hudson | Tim Hudson | Livan Hernandez | | 353 | 365 | -12 |
| 2011-07-16 | @ ATL | 94 | W 5-2 | 47-47 | 4 | 42,456 | John Lannan | Tommy Hanson | John Lannan | Tommy Hanson | Drew Storen | 358 | 367 | -9 |
| 2011-07-17 | @ ATL | 95 | L 8-9 | 47-48 | 4 | 30,314 | Tom Gorzelanny | Jair Jurrjens | Craig Kimbrel | Ryan Mattheus | | 366 | 376 | -10 |
| 2011-07-18 | @ HOU | 96 | W 5-2 | 48-48 | 3 | 28,975 | Jason Marquis | Jordan Lyles | Jason Marquis | Jordan Lyles | Drew Storen | 371 | 378 | -7 |
| 2011-07-19 | @ HOU | 97 | L 6-7 | 48-49 | 4 | 32,418 | Jordan Zimmermann | J.A. Happ | J.A. Happ | Jordan Zimmermann | Mark Melancon | 377 | 385 | -8 |
| 2011-07-20 | @ HOU | 98 | L 2-3 | 48-50 | 4 | 29,605 | Livan Hernandez | Brett Myers | Wilton Lopez | Todd Coffey | | 379 | 388 | -9 |
| 2011-07-22 | @ LAN | 99 | W 7-2 | 49-50 | 4 | 39,839 | John Lannan | Hiroki Kuroda | John Lannan | Hiroki Kuroda | | 386 | 390 | -4 |
| 2011-07-23 | @ LAN | 100 | L 6-7 | 49-51 | 4 | 34,590 | Tom Gorzelanny | Ted Lilly | Javy Guerra | Ryan Mattheus | | 392 | 397 | -5 |
| 2011-07-24 | @ LAN | 101 | L 1-3 | 49-52 | 4 | 36,458 | Jason Marquis | Chad Billingsley | Chad Billingsley | Jason Marquis | Javy Guerra | 393 | 400 | -7 |
| 2011-07-26 | vs FLO | 102 | L 2-11 | 49-53 | 5 | 24,650 | Jordan Zimmermann | Ricky Nolasco | Ricky Nolasco | Jordan Zimmermann | | 395 | 411 | -16 |
| 2011-07-27 | vs FLO | 103 | L 5-7 | 49-54 | 5 | 21,974 | Livan Hernandez | Javier Vazquez | Javier Vazquez | Livan Hernandez | Leo Nunez | 400 | 418 | -18 |
| 2011-07-28 | vs FLO | 104 | L 2-5 | 49-55 | 5 | 24,153 | John Lannan | Brad Hand | Brian Sanches | John Lannan | | 402 | 423 | -21 |
| 2011-07-29 | vs NYN | 105 | L 5-8 | 49-56 | 5 | 30,114 | Chien-Ming Wang | Dillon Gee | Dillon Gee | Chien-Ming Wang | Jason Isringhausen | 407 | 431 | -24 |
| 2011-07-30 | vs NYN | 106 | W 3-0 | 50-56 | 5 | 35,414 | Yuniesky Maya | R.A. Dickey | Yuniesky Maya | R.A. Dickey | Drew Storen | 410 | 431 | -21 |
| 2011-07-31 | vs NYN | 107 | W 3-2 | 51-56 | 5 | 25,307 | Jordan Zimmermann | Jonathon Niese | Drew Storen | Bobby Parnell | | 413 | 433 | -20 |
| 2011-08-01 | vs ATL | 108 | W 5-3 | 52-56 | 5 | 19,940 | Livan Hernandez | Jair Jurrjens | Livan Hernandez | Jair Jurrjens | Drew Storen | 418 | 436 | -18 |
| 2011-08-02 | vs ATL | 109 | W 9-3 | 53-56 | 5 | 24,326 | John Lannan | Derek Lowe | John Lannan | Derek Lowe | | 427 | 439 | -12 |
| 2011-08-03 | vs ATL | 110 | L 4-6 | 53-57 | 5 | 20,043 | Chien-Ming Wang | Brandon Beachy | Brandon Beachy | Chien-Ming Wang | Craig Kimbrel | 431 | 445 | -14 |
| 2011-08-04 | @ COL | 111 | L 3-6 | 53-58 | 5 | 35,956 | Ross Detwiler | Esmil Rogers | Esmil Rogers | Ross Detwiler | | 434 | 451 | -17 |
| 2011-08-05 | @ COL | 112 | W 5-3 | 54-58 | 5 | 35,034 | Jordan Zimmermann | Juan Nicasio | Jordan Zimmermann | Juan Nicasio | Drew Storen | 439 | 454 | -15 |
| 2011-08-06 | @ COL | 113 | L 7-15 | 54-59 | 5 | 43,321 | Livan Hernandez | Jhoulis Chacin | Jhoulis Chacin | Livan Hernandez | | 446 | 469 | -23 |
| 2011-08-07 | @ COL | 114 | W 3-2 | 55-59 | 5 | 34,812 | John Lannan | Aaron Cook | Tyler Clippard | Matt Belisle | Drew Storen | 449 | 471 | -22 |
| 2011-08-09 | @ CHN | 115 | W 3-1 | 56-59 | 4 | 37,109 | Chien-Ming Wang | Matt Garza | Chien-Ming Wang | Matt Garza | Drew Storen | 452 | 472 | -20 |
| 2011-08-10 | @ CHN | 116 | L 2-4 | 56-60 | 4 | 38,010 | Ross Detwiler | Rodrigo Lopez | Rodrigo Lopez | Ross Detwiler | Carlos Marmol | 454 | 476 | -22 |
| 2011-08-11 | @ CHN | 117 | L 3-4 | 56-61 | 4 | 34,733 | Jordan Zimmermann | Ryan Dempster | Ryan Dempster | Jordan Zimmermann | Carlos Marmol | 457 | 480 | -23 |
| 2011-08-12 | @ PHI | 118 | W 4-2 | 57-61 | 4 | 45,762 | Livan Hernandez | Cole Hamels | Livan Hernandez | Cole Hamels | Drew Storen | 461 | 482 | -21 |
| 2011-08-13 | @ PHI | 119 | L 3-11 | 57-62 | 4 | 45,570 | John Lannan | Roy Oswalt | Roy Oswalt | John Lannan | | 464 | 493 | -29 |
| 2011-08-16 | vs CIN | 120 | W 6-4 | 58-62 | 4 | 23,888 | Chien-Ming Wang | Mike Leake | Chien-Ming Wang | Mike Leake | Drew Storen | 470 | 497 | -27 |
| 2011-08-17 | vs CIN | 121 | L 1-2 | 58-63 | 4 | 20,374 | Ross Detwiler | Johnny Cueto | Johnny Cueto | Ross Detwiler | Francisco Cordero | 471 | 499 | -28 |
| 2011-08-18 | vs CIN | 122 | W 3-1 | 59-63 | 4 | 19,508 | Jordan Zimmermann | Bronson Arroyo | Jordan Zimmermann | Bronson Arroyo | Drew Storen | 474 | 500 | -26 |
| 2011-08-19 | vs PHI | 123 | W 8-4 | 60-63 | 3 | 37,841 | Livan Hernandez | Roy Oswalt | Todd Coffey | Ryan Madson | | 482 | 504 | -22 |
| 2011-08-20 | vs PHI | 124 | L 0-5 | 60-64 | 3 | 44,685 | John Lannan | Roy Oswalt | Roy Oswalt | John Lannan | | 482 | 509 | -27 |
| 2011-08-21 | vs PHI | 125 | W 5-4 | 61-64 | 3 | 41,727 | Chien-Ming Wang | Roy Halladay | Sean Burnett | Brad Lidge | | 487 | 513 | -26 |
| 2011-08-22 | vs ARI | 126 | W 4-1 | 62-64 | 3 | 19,377 | Ross Detwiler | Joe Saunders | Ross Detwiler | Joe Saunders | Drew Storen | 491 | 514 | -23 |
| 2011-08-23 | vs ARI | 127 | L 0-2 | 62-65 | 3 | 17,029 | Jordan Zimmermann | Ian Kennedy | Ian Kennedy | Jordan Zimmermann | J.J. Putz | 491 | 516 | -25 |
| 2011-08-24 | vs ARI | 128 | L 2-4 | 62-66 | 3 | 17,881 | Livan Hernandez | Daniel Hudson | Daniel Hudson | Livan Hernandez | J.J. Putz | 493 | 520 | -27 |
| 2011-08-25 | vs ARI | 129 | L 1-8 | 62-67 | 3 | 17,666 | John Lannan | Wade Miley | Wade Miley | John Lannan | | 494 | 528 | -34 |
| 2011-08-26 | @ CIN | 130 | L 3-4 | 62-68 | 4 | 35,089 | Chien-Ming Wang | Dontrelle Willis | Francisco Cordero | Collin Balester | | 497 | 532 | -35 |
| 2011-08-27 | @ CIN | 131 | L 3-6 | 62-69 | 4 | 30,423 | Ross Detwiler | Mike Leake | Mike Leake | Ross Detwiler | Francisco Cordero | 500 | 538 | -38 |
| 2011-08-28 | @ CIN | 132 | L 4-5 | 62-70 | 4 | 28,415 | Jordan Zimmermann | Johnny Cueto | Bill Bray | Collin Balester | | 504 | 543 | -39 |
| 2011-08-30 | @ ATL | 133 | W 9-2 | 63-70 | 4 | 16,674 | Livan Hernandez | Jair Jurrjens | Livan Hernandez | Jair Jurrjens | | 513 | 545 | -32 |
| 2011-08-31 | @ ATL | 134 | L 1-3 | 63-71 | 4 | 20,687 | John Lannan | Derek Lowe | Derek Lowe | John Lannan | Craig Kimbrel | 514 | 548 | -34 |
| 2011-09-01 | @ ATL | 135 | L 2-5 | 63-72 | 4 | 18,794 | Chien-Ming Wang | Tim Hudson | Tim Hudson | Chien-Ming Wang | Craig Kimbrel | 516 | 553 | -37 |
| 2011-09-02 | vs NYN | 136 | L 3-7 | 63-73 | 4 | 27,907 | Ross Detwiler | R.A. Dickey | R.A. Dickey | Ross Detwiler | | 519 | 560 | -41 |
| 2011-09-03 | vs NYN | 137 | W 8-7 | 64-73 | 4 | 34,821 | Tom Milone | Dillon Gee | Sean Burnett | Bobby Parnell | | 527 | 567 | -40 |
| 2011-09-04 | vs NYN | 138 | L 3-6 | 64-74 | 4 | 29,679 | Livan Hernandez | Mike Pelfrey | Ryota Igarashi | Livan Hernandez | Bobby Parnell | 530 | 573 | -43 |
| 2011-09-05 | vs LAN | 139 | W 7-2 | 65-74 | 4 | 25,518 | John Lannan | Hiroki Kuroda | John Lannan | Hiroki Kuroda | | 537 | 575 | -38 |
| 2011-09-06 | vs LAN | 140 | L 3-7 | 65-75 | 4 | 29,092 | Stephen Strasburg | Ted Lilly | Kenley Jansen | Henry Rodriguez | | 540 | 582 | -42 |
| 2011-09-08 | vs LAN | 141 | L 4-7 | 65-76 | 6 | 21,638 | Chien-Ming Wang | Chad Billingsley | Mike MacDougal | Drew Storen | Javy Guerra | 544 | 589 | -45 |
| 2011-09-09 | vs HOU | 142 | W 4-3 | 66-76 | 4 | 18,307 | Tom Milone | Bud Norris | Tyler Clippard | Lucas Harrell | | 548 | 592 | -44 |
| 2011-09-10 | vs HOU | 143 | L 3-9 | 66-77 | 4 | 30,935 | John Lannan | Wandy Rodriguez | Wandy Rodriguez | John Lannan | | 551 | 601 | -50 |
| 2011-09-11 | vs HOU | 144 | W 8-2 | 67-77 | 4 | 24,238 | Stephen Strasburg | Henry Sosa | Tom Gorzelanny | Henry Sosa | | 559 | 603 | -44 |
| 2011-09-12 | @ NYN | 145 | W 3-2 | 68-77 | 4 | 27,015 | Ross Detwiler | R.A. Dickey | Todd Coffey | R.A. Dickey | Drew Storen | 562 | 605 | -43 |
| 2011-09-13 | @ NYN | 146 | W 3-2 | 69-77 | 4 | 25,359 | Chien-Ming Wang | Dillon Gee | Craig Stammen | Dale Thayer | Drew Storen | 565 | 607 | -42 |
| 2011-09-14 | @ NYN | 147 | W 2-0 | 70-77 | 4 | 26,885 | Brad Peacock | Mike Pelfrey | Brad Peacock | Mike Pelfrey | Drew Storen | 567 | 607 | -40 |
| 2011-09-15 | @ NYN | 148 | W 10-1 | 71-77 | 4 | 22,205 | Tom Milone | Chris Schwinden | Tom Milone | Chris Schwinden | | 577 | 608 | -31 |
| 2011-09-16 | vs FLO | 149 | L 0-3 | 71-78 | 4 | 22,932 | John Lannan | Javier Vazquez | Javier Vazquez | John Lannan | | 577 | 611 | -34 |
| 2011-09-17 | vs FLO | 150 | L 1-4 | 71-79 | 4 | 33,247 | Stephen Strasburg | Chris Volstad | Clay Hensley | Collin Balester | Leo Nunez | 578 | 615 | -37 |
| 2011-09-18 | vs FLO | 151 | W 4-3 | 72-79 | 4 | 26,581 | Chien-Ming Wang | Brad Hand | Chien-Ming Wang | Brad Hand | Drew Storen | 582 | 618 | -36 |
| 2011-09-20 | @ PHI | 152 | W 4-3 | 73-79 | 5 | 44,263 | Tom Milone | Kyle Kendrick | Tom Gorzelanny | Michael Stutes | Drew Storen | 586 | 621 | -35 |
| 2011-09-20 | @ PHI | 153 | W 3-0 | 73-79 | 5 | 45,408 | Ross Detwiler | Cliff Lee | Ross Detwiler | Cliff Lee | Drew Storen | 589 | 621 | -32 |
| 2011-09-21 | @ PHI | 154 | W 7-5 | 75-79 | 3 | 45,083 | John Lannan | Vance Worley | John Lannan | Vance Worley | Henry Rodriguez | 596 | 626 | -30 |
| 2011-09-22 | @ PHI | 155 | W 6-1 | 76-79 | 3 | 45,064 | Brad Peacock | Roy Oswalt | Brad Peacock | Roy Oswalt | | 602 | 627 | -25 |
| 2011-09-23 | vs ATL | 156 | L 4-7 | 76-80 | 3 | 28,817 | Stephen Strasburg | Tim Hudson | Tim Hudson | Stephen Strasburg | Craig Kimbrel | 606 | 634 | -28 |
| 2011-09-24 | vs ATL | 157 | W 4-1 | 77-80 | 4 | 33,986 | Chien-Ming Wang | Brandon Beachy | Chien-Ming Wang | Brandon Beachy | Drew Storen | 610 | 635 | -25 |
| 2011-09-25 | vs ATL | 158 | W 3-0 | 78-80 | 3 | 37,638 | Ross Detwiler | Mike Minor | Ross Detwiler | Mike Minor | Drew Storen | 613 | 635 | -22 |
| 2011-09-26 | @ FLO | 159 | W 6-4 | 79-80 | 3 | 21,058 | Tom Milone | Anibal Sanchez | Atahualpa Severino | Edward Mujica | Henry Rodriguez | 619 | 639 | -20 |
| 2011-09-27 | @ FLO | 160 | L 2-3 | 79-81 | 3 | 21,902 | John Lannan | Javier Vazquez | Javier Vazquez | Doug Slaten | | 621 | 642 | -21 |
| 2011-09-28 | @ FLO | 161 | W 3-1 | 80-81 | 3 | 34,615 | Stephen Strasburg | Chris Volstad | Stephen Strasburg | Chris Volstad | Drew Storen | 624 | 643 | -19 |