| 2011-04-01 | vs MIN | 1 | W 13-3 | 1-0 | 2 | 47,984 | Ricky Romero | Carl Pavano | Ricky Romero | Carl Pavano | | 13 | 3 | 10 |
| 2011-04-02 | vs MIN | 2 | W 6-1 | 2-0 | 3 | 27,194 | Kyle Drabek | Francisco Liriano | Kyle Drabek | Francisco Liriano | | 19 | 4 | 15 |
| 2011-04-03 | vs MIN | 3 | L 3-4 | 2-1 | 3 | 35,505 | Brett Cecil | Nick Blackburn | Nick Blackburn | Brett Cecil | Joe Nathan | 22 | 8 | 14 |
| 2011-04-05 | vs OAK | 4 | W 7-6 | 3-1 | 2 | 11,077 | Jo-Jo Reyes | Brandon McCarthy | Jason Frasor | Grant Balfour | | 29 | 14 | 15 |
| 2011-04-06 | vs OAK | 5 | W 5-3 | 4-1 | 2 | 11,684 | Jesse Litsch | Dallas Braden | Jesse Litsch | Dallas Braden | Jon Rauch | 34 | 17 | 17 |
| 2011-04-07 | vs OAK | 6 | L 1-2 | 4-2 | 3 | 19,528 | Ricky Romero | Trevor Cahill | Trevor Cahill | Jason Frasor | Brian Fuentes | 35 | 19 | 16 |
| 2011-04-08 | @ ANA | 7 | W 3-2 | 5-2 | 2 | 43,853 | Kyle Drabek | Ervin Santana | Octavio Dotel | Ervin Santana | Jon Rauch | 38 | 21 | 17 |
| 2011-04-09 | @ ANA | 8 | L 5-6 | 5-3 | 4 | 43,513 | Brett Cecil | Matt Palmer | Dan Haren | Jon Rauch | | 43 | 27 | 16 |
| 2011-04-10 | @ ANA | 9 | L 1-3 | 5-4 | 3 | 43,525 | Jo-Jo Reyes | Jered Weaver | Jered Weaver | Jo-Jo Reyes | Fernando Rodney | 44 | 30 | 14 |
| 2011-04-11 | @ SEA | 10 | L 7-8 | 5-5 | 3 | 13,056 | Jesse Litsch | Felix Hernandez | Josh Lueke | Shawn Camp | | 51 | 38 | 13 |
| 2011-04-12 | @ SEA | 11 | L 2-3 | 5-6 | 3 | 15,500 | Ricky Romero | Michael Pineda | Michael Pineda | Ricky Romero | Brandon League | 53 | 41 | 12 |
| 2011-04-13 | @ SEA | 12 | W 8-3 | 6-6 | 3 | 12,407 | Kyle Drabek | Jason Vargas | Marc Rzepczynski | Chris Ray | | 61 | 44 | 17 |
| 2011-04-15 | @ BOS | 13 | W 7-6 | 7-6 | 2 | 37,467 | Brett Cecil | Clay Buchholz | Brett Cecil | Bobby Jenks | Jon Rauch | 68 | 50 | 18 |
| 2011-04-16 | @ BOS | 14 | L 1-4 | 7-7 | 2 | 37,310 | Jo-Jo Reyes | Josh Beckett | Josh Beckett | Jo-Jo Reyes | Jonathan Papelbon | 69 | 54 | 15 |
| 2011-04-17 | @ BOS | 15 | L 1-8 | 7-8 | 2 | 37,802 | Jesse Litsch | Jon Lester | Jon Lester | Jesse Litsch | | 70 | 62 | 8 |
| 2011-04-18 | @ BOS | 16 | L 1-9 | 7-9 | 3 | 37,916 | Ricky Romero | Daisuke Matsuzaka | Daisuke Matsuzaka | Ricky Romero | | 71 | 71 | 0 |
| 2011-04-19 | vs NYA | 17 | W 6-5 | 8-9 | 3 | 25,250 | Kyle Drabek | A.J. Burnett | Jon Rauch | Ivan Nova | | 77 | 76 | 1 |
| 2011-04-20 | vs NYA | 18 | L 2-6 | 8-10 | 4 | 26,062 | Brett Cecil | Bartolo Colon | Bartolo Colon | Brett Cecil | Rafael Soriano | 79 | 82 | -3 |
| 2011-04-22 | vs TBA | 19 | W 6-4 | 9-10 | 2 | 23,192 | Jo-Jo Reyes | Jeremy Hellickson | Marc Rzepczynski | Adam Russell | | 85 | 86 | -1 |
| 2011-04-23 | vs TBA | 20 | L 4-6 | 9-11 | 4 | 21,826 | Brandon Morrow | David Price | David Price | Brandon Morrow | Kyle Farnsworth | 89 | 92 | -3 |
| 2011-04-24 | vs TBA | 21 | L 0-2 | 9-12 | 4 | 14,456 | Ricky Romero | James Shields | James Shields | Ricky Romero | | 89 | 94 | -5 |
| 2011-04-25 | @ TEX | 22 | W 6-4 | 10-12 | 4 | 22,915 | Kyle Drabek | Colby Lewis | Kyle Drabek | Colby Lewis | Jon Rauch | 95 | 98 | -3 |
| 2011-04-26 | @ TEX | 23 | W 10-3 | 11-12 | 3 | 21,755 | Jesse Litsch | Matt Harrison | Jesse Litsch | Matt Harrison | | 105 | 101 | 4 |
| 2011-04-27 | @ TEX | 24 | L 6-7 | 11-13 | 3 | 29,322 | Jo-Jo Reyes | Derek Holland | Cody Eppley | Octavio Dotel | Darren Oliver | 111 | 108 | 3 |
| 2011-04-28 | @ TEX | 25 | W 5-2 | 12-13 | 4 | 24,121 | Brandon Morrow | Alexi Ogando | Frank Francisco | Darren Oliver | | 116 | 110 | 6 |
| 2011-04-29 | @ NYA | 26 | W 5-3 | 13-13 | 3 | 40,830 | Ricky Romero | Freddy Garcia | Ricky Romero | Freddy Garcia | Jon Rauch | 121 | 113 | 8 |
| 2011-04-30 | @ NYA | 27 | L 4-5 | 13-14 | 3 | 42,460 | Kyle Drabek | A.J. Burnett | A.J. Burnett | Kyle Drabek | Mariano Rivera | 125 | 118 | 7 |
| 2011-05-01 | @ NYA | 28 | L 2-5 | 13-15 | 4 | 43,363 | Jesse Litsch | Ivan Nova | Ivan Nova | Jesse Litsch | Mariano Rivera | 127 | 123 | 4 |
| 2011-05-03 | @ TBA | 29 | L 2-3 | 13-16 | 5 | 10,248 | Jo-Jo Reyes | Wade Davis | Kyle Farnsworth | Jon Rauch | | 129 | 126 | 3 |
| 2011-05-04 | @ TBA | 30 | W 3-2 | 14-16 | 5 | 10,099 | Brandon Morrow | Jeff Niemann | Brandon Morrow | Jeff Niemann | Frank Francisco | 132 | 128 | 4 |
| 2011-05-05 | @ TBA | 31 | L 1-3 | 14-17 | 5 | 12,682 | Kyle Drabek | David Price | David Price | Kyle Drabek | Kyle Farnsworth | 133 | 131 | 2 |
| 2011-05-06 | vs DET | 32 | W 7-4 | 15-17 | 3 | 19,711 | Jesse Litsch | Phil Coke | Jesse Litsch | Phil Coke | Frank Francisco | 140 | 135 | 5 |
| 2011-05-07 | vs DET | 33 | L 0-9 | 15-18 | 4 | 23,453 | Ricky Romero | Justin Verlander | Justin Verlander | Ricky Romero | | 140 | 144 | -4 |
| 2011-05-08 | vs DET | 34 | L 2-5 | 15-19 | 4 | 17,392 | Jo-Jo Reyes | Brad Penny | Brad Penny | Jo-Jo Reyes | Jose Valverde | 142 | 149 | -7 |
| 2011-05-09 | vs DET | 35 | L 5-10 | 15-20 | 4 | 11,785 | Brandon Morrow | Max Scherzer | Max Scherzer | Brandon Morrow | | 147 | 159 | -12 |
| 2011-05-10 | vs BOS | 36 | W 7-6 | 16-20 | 4 | 17,820 | Kyle Drabek | Jon Lester | Carlos Villanueva | Matt Albers | | 154 | 165 | -11 |
| 2011-05-11 | vs BOS | 37 | W 9-3 | 17-20 | 4 | 19,163 | Jesse Litsch | John Lackey | Jesse Litsch | John Lackey | | 163 | 168 | -5 |
| 2011-05-13 | @ MIN | 38 | W 2-0 | 18-20 | 4 | 38,809 | Ricky Romero | Carl Pavano | Ricky Romero | Alex Burnett | Frank Francisco | 165 | 168 | -3 |
| 2011-05-14 | @ MIN | 39 | W 9-3 | 19-20 | 4 | 39,934 | Jo-Jo Reyes | Nick Blackburn | Jon Rauch | Glen Perkins | | 174 | 171 | 3 |
| 2011-05-15 | @ MIN | 40 | W 11-3 | 20-20 | 4 | 39,301 | Brandon Morrow | Brian Duensing | Brandon Morrow | Brian Duensing | | 185 | 174 | 11 |
| 2011-05-16 | @ DET | 41 | W 4-2 | 21-20 | 4 | 20,444 | Kyle Drabek | Max Scherzer | Kyle Drabek | Joaquin Benoit | Frank Francisco | 189 | 176 | 13 |
| 2011-05-18 | vs TBA | 42 | L 5-6 | 21-21 | 4 | 14,415 | Jesse Litsch | Jeremy Hellickson | Jeremy Hellickson | Jesse Litsch | Kyle Farnsworth | 194 | 182 | 12 |
| 2011-05-19 | vs TBA | 43 | W 3-2 | 22-21 | 4 | 12,590 | Ricky Romero | Wade Davis | Ricky Romero | Wade Davis | Frank Francisco | 197 | 184 | 13 |
| 2011-05-20 | vs HOU | 44 | L 2-5 | 22-22 | 4 | 15,478 | Jo-Jo Reyes | Aneury Rodriguez | Wilton Lopez | Frank Francisco | Mark Melancon | 199 | 189 | 10 |
| 2011-05-21 | vs HOU | 45 | W 7-5 | 23-22 | 4 | 21,494 | Brandon Morrow | Brett Myers | Casey Janssen | Brett Myers | Octavio Dotel | 206 | 194 | 12 |
| 2011-05-22 | vs HOU | 46 | L 2-3 | 23-23 | 4 | 19,487 | Kyle Drabek | Wandy Rodriguez | Wandy Rodriguez | Kyle Drabek | Mark Melancon | 208 | 197 | 11 |
| 2011-05-23 | @ NYA | 47 | W 7-3 | 24-23 | 4 | 41,946 | Carlos Villanueva | Bartolo Colon | Carlos Villanueva | Bartolo Colon | | 215 | 200 | 15 |
| 2011-05-24 | @ NYA | 48 | L 4-5 | 24-24 | 4 | 41,519 | Ricky Romero | CC Sabathia | CC Sabathia | Frank Francisco | | 219 | 205 | 14 |
| 2011-05-25 | @ NYA | 49 | L 3-7 | 24-25 | 4 | 43,201 | Jo-Jo Reyes | Freddy Garcia | Freddy Garcia | Jo-Jo Reyes | | 222 | 212 | 10 |
| 2011-05-26 | vs CHA | 50 | L 1-3 | 24-26 | 5 | 14,353 | Brandon Morrow | Philip Humber | Jesse Crain | Marc Rzepczynski | Sergio Santos | 223 | 215 | 8 |
| 2011-05-27 | vs CHA | 51 | W 4-2 | 25-26 | 4 | 16,668 | Kyle Drabek | Mark Buehrle | Casey Janssen | Mark Buehrle | Jon Rauch | 227 | 217 | 10 |
| 2011-05-28 | vs CHA | 52 | W 9-8 | 26-26 | 4 | 22,659 | Carlos Villanueva | Edwin Jackson | Luis Perez | Gavin Floyd | | 236 | 225 | 11 |
| 2011-05-29 | vs CHA | 53 | W 13-4 | 27-26 | 5 | 18,325 | Ricky Romero | John Danks | Ricky Romero | John Danks | | 249 | 229 | 20 |
| 2011-05-30 | vs CLE | 54 | W 11-1 | 28-26 | 4 | 12,902 | Jo-Jo Reyes | Fausto Carmona | Jo-Jo Reyes | Fausto Carmona | | 260 | 230 | 30 |
| 2011-05-31 | vs CLE | 55 | L 3-6 | 28-27 | 4 | 14,556 | Brandon Morrow | Mitch Talbot | Mitch Talbot | Brandon Morrow | | 263 | 236 | 27 |
| 2011-06-01 | vs CLE | 56 | L 9-13 | 28-28 | 4 | 15,397 | Kyle Drabek | Josh Tomlin | Josh Tomlin | Kyle Drabek | | 272 | 249 | 23 |
| 2011-06-03 | @ BAL | 57 | W 8-4 | 29-28 | 4 | 18,587 | Carlos Villanueva | Zachary Britton | Carlos Villanueva | Zachary Britton | | 280 | 253 | 27 |
| 2011-06-04 | @ BAL | 58 | L 3-5 | 29-29 | 4 | 20,086 | Ricky Romero | Jake Arrieta | Jake Arrieta | Ricky Romero | Kevin Gregg | 283 | 258 | 25 |
| 2011-06-05 | @ BAL | 59 | W 7-4 | 30-29 | 4 | 25,431 | Jo-Jo Reyes | Jeremy Guthrie | Jo-Jo Reyes | Jeremy Guthrie | | 290 | 262 | 28 |
| 2011-06-06 | @ KCA | 60 | L 2-3 | 30-30 | 4 | 12,194 | Brandon Morrow | Felipe Paulino | Joakim Soria | Frank Francisco | | 292 | 265 | 27 |
| 2011-06-07 | @ KCA | 61 | W 8-5 | 31-30 | 4 | 16,539 | Kyle Drabek | Vin Mazzaro | Kyle Drabek | Vin Mazzaro | Jon Rauch | 300 | 270 | 30 |
| 2011-06-08 | @ KCA | 62 | W 9-8 | 32-30 | 4 | 12,152 | Carlos Villanueva | Danny Duffy | Carlos Villanueva | Danny Duffy | Casey Janssen | 309 | 278 | 31 |
| 2011-06-09 | @ KCA | 63 | L 2-3 | 32-31 | 4 | 13,941 | Ricky Romero | Luke Hochevar | Luke Hochevar | Ricky Romero | Joakim Soria | 311 | 281 | 30 |
| 2011-06-10 | vs BOS | 64 | L 1-5 | 32-32 | 4 | 28,588 | Jo-Jo Reyes | Clay Buchholz | Clay Buchholz | Jo-Jo Reyes | | 312 | 286 | 26 |
| 2011-06-11 | vs BOS | 65 | L 4-16 | 32-33 | 4 | 39,437 | Brandon Morrow | John Lackey | John Lackey | Brandon Morrow | | 316 | 302 | 14 |
| 2011-06-12 | vs BOS | 66 | L 1-14 | 32-34 | 4 | 30,364 | Kyle Drabek | Jon Lester | Jon Lester | Kyle Drabek | | 317 | 316 | 1 |
| 2011-06-14 | vs BAL | 67 | W 6-5 | 33-34 | 4 | 15,592 | Carlos Villanueva | Chris Jakubauskas | Shawn Camp | Koji Uehara | | 323 | 321 | 2 |
| 2011-06-15 | vs BAL | 68 | W 4-1 | 34-34 | 4 | 14,541 | Ricky Romero | Jake Arrieta | Ricky Romero | Jake Arrieta | Frank Francisco | 327 | 322 | 5 |
| 2011-06-16 | vs BAL | 69 | L 3-4 | 34-35 | 4 | 31,822 | Zach Stewart | Jeremy Guthrie | Jason Berken | Jon Rauch | Kevin Gregg | 330 | 326 | 4 |
| 2011-06-17 | @ CIN | 70 | W 3-2 | 35-35 | 4 | 32,026 | Jo-Jo Reyes | Mike Leake | Jo-Jo Reyes | Mike Leake | Frank Francisco | 333 | 328 | 5 |
| 2011-06-18 | @ CIN | 71 | W 4-0 | 36-35 | 4 | 31,688 | Brandon Morrow | Edinson Volquez | Brandon Morrow | Edinson Volquez | | 337 | 328 | 9 |
| 2011-06-19 | @ CIN | 72 | L 1-2 | 36-36 | 4 | 32,618 | Carlos Villanueva | Bronson Arroyo | Bronson Arroyo | Carlos Villanueva | Francisco Cordero | 338 | 330 | 8 |
| 2011-06-20 | @ ATL | 73 | L 0-2 | 36-37 | 4 | 22,937 | Ricky Romero | Tim Hudson | Tim Hudson | Ricky Romero | Craig Kimbrel | 338 | 332 | 6 |
| 2011-06-21 | @ ATL | 74 | L 1-5 | 36-38 | 4 | 26,849 | Zach Stewart | Mike Minor | Mike Minor | Zach Stewart | | 339 | 337 | 2 |
| 2011-06-22 | @ ATL | 75 | L 1-5 | 36-39 | 5 | 23,152 | Jo-Jo Reyes | Brandon Beachy | Brandon Beachy | Jo-Jo Reyes | | 340 | 342 | -2 |
| 2011-06-24 | @ SLN | 76 | W 5-4 | 37-39 | 4 | 37,724 | Brandon Morrow | Jake Westbrook | Jason Frasor | Fernando Salas | Frank Francisco | 345 | 346 | -1 |
| 2011-06-25 | @ SLN | 77 | W 6-3 | 38-39 | 4 | 40,289 | Carlos Villanueva | Jaime Garcia | Carlos Villanueva | Jaime Garcia | | 351 | 349 | 2 |
| 2011-06-26 | @ SLN | 78 | W 5-0 | 39-39 | 4 | 36,542 | Ricky Romero | Kyle McClellan | Ricky Romero | Kyle McClellan | | 356 | 349 | 7 |
| 2011-06-27 | @ DET | 79 | L 2-4 | 39-40 | 4 | 25,181 | Zach Stewart | Max Scherzer | Joaquin Benoit | Marc Rzepczynski | Jose Valverde | 358 | 353 | 5 |
| 2011-06-28 | vs PIT | 80 | L 6-7 | 39-41 | 4 | 17,085 | Jo-Jo Reyes | Kevin Correia | Kevin Correia | Jo-Jo Reyes | Joel Hanrahan | 364 | 360 | 4 |
| 2011-06-29 | vs PIT | 81 | W 2-1 | 40-41 | 4 | 15,632 | Brandon Morrow | Paul Maholm | Brandon Morrow | Paul Maholm | Frank Francisco | 366 | 361 | 5 |
| 2011-06-30 | vs PIT | 82 | L 2-6 | 40-42 | 4 | 14,939 | Brett Cecil | Jeff Karstens | Jeff Karstens | Brett Cecil | | 368 | 367 | 1 |
| 2011-07-01 | vs PHI | 83 | L 6-7 | 40-43 | 4 | 45,512 | Ricky Romero | Kyle Kendrick | Danys Baez | Frank Francisco | Antonio Bastardo | 374 | 374 | 0 |
| 2011-07-02 | vs PHI | 84 | L 3-5 | 40-44 | 4 | 44,078 | Carlos Villanueva | Roy Halladay | Roy Halladay | Luis Perez | | 377 | 379 | -2 |
| 2011-07-03 | vs PHI | 85 | W 7-4 | 41-44 | 4 | 26,204 | Jo-Jo Reyes | Cliff Lee | Octavio Dotel | Cliff Lee | | 384 | 383 | 1 |
| 2011-07-04 | @ BOS | 86 | W 9-7 | 42-44 | 4 | 38,072 | Brandon Morrow | John Lackey | Brandon Morrow | John Lackey | Frank Francisco | 393 | 390 | 3 |
| 2011-07-05 | @ BOS | 87 | L 2-3 | 42-45 | 4 | 37,745 | Brett Cecil | Jon Lester | Matt Albers | Brett Cecil | Jonathan Papelbon | 395 | 393 | 2 |
| 2011-07-06 | @ BOS | 88 | L 4-6 | 42-46 | 4 | 37,404 | Ricky Romero | Tim Wakefield | Tim Wakefield | Ricky Romero | Jonathan Papelbon | 399 | 399 | 0 |
| 2011-07-07 | @ CLE | 89 | L 4-5 | 42-47 | 4 | 18,816 | Carlos Villanueva | Zach McAllister | Tony Sipp | Luis Perez | | 403 | 404 | -1 |
| 2011-07-08 | @ CLE | 90 | W 11-7 | 43-47 | 4 | 25,835 | Jo-Jo Reyes | Mitch Talbot | Jo-Jo Reyes | Mitch Talbot | | 414 | 411 | 3 |
| 2011-07-09 | @ CLE | 91 | W 5-4 | 44-47 | 4 | 27,661 | Brandon Morrow | Josh Tomlin | Jon Rauch | Chris Perez | Shawn Camp | 419 | 415 | 4 |
| 2011-07-10 | @ CLE | 92 | W 7-1 | 45-47 | 4 | 21,148 | Brett Cecil | Carlos Carrasco | Brett Cecil | Carlos Carrasco | | 426 | 416 | 10 |
| 2011-07-14 | vs NYA | 93 | W 16-7 | 46-47 | 4 | 37,342 | Jo-Jo Reyes | Bartolo Colon | Jo-Jo Reyes | Bartolo Colon | | 442 | 423 | 19 |
| 2011-07-15 | vs NYA | 94 | W 7-1 | 47-47 | 4 | 33,525 | Brandon Morrow | Freddy Garcia | Brandon Morrow | Freddy Garcia | | 449 | 424 | 25 |
| 2011-07-16 | vs NYA | 95 | L 1-4 | 47-48 | 4 | 45,606 | Ricky Romero | CC Sabathia | CC Sabathia | Ricky Romero | Mariano Rivera | 450 | 428 | 22 |
| 2011-07-17 | vs NYA | 96 | L 2-7 | 47-49 | 4 | 36,586 | Carlos Villanueva | Phil Hughes | Phil Hughes | Carlos Villanueva | | 452 | 435 | 17 |
| 2011-07-19 | vs SEA | 97 | W 6-5 | 48-49 | 4 | 15,957 | Brett Cecil | Michael Pineda | Casey Janssen | Jamey Wright | | 458 | 440 | 18 |
| 2011-07-20 | vs SEA | 98 | W 11-6 | 49-49 | 4 | 18,093 | Brandon Morrow | Jason Vargas | Brandon Morrow | Jason Vargas | | 469 | 446 | 23 |
| 2011-07-21 | vs SEA | 99 | W 7-5 | 50-49 | 4 | 23,146 | Ricky Romero | Doug Fister | Jon Rauch | David Pauley | | 476 | 451 | 25 |
| 2011-07-22 | @ TEX | 100 | L 2-12 | 50-50 | 4 | 37,360 | Jo-Jo Reyes | Colby Lewis | Colby Lewis | Jo-Jo Reyes | | 478 | 463 | 15 |
| 2011-07-23 | @ TEX | 101 | L 4-5 | 50-51 | 4 | 38,537 | Carlos Villanueva | Matt Harrison | Darren Oliver | Marc Rzepczynski | | 482 | 468 | 14 |
| 2011-07-24 | @ TEX | 102 | W 3-0 | 51-51 | 4 | 43,117 | Brett Cecil | Alexi Ogando | Brett Cecil | Alexi Ogando | | 485 | 468 | 17 |
| 2011-07-26 | vs BAL | 103 | L 4-12 | 51-52 | 4 | 17,477 | Brandon Morrow | Jake Arrieta | Jake Arrieta | Brandon Morrow | | 489 | 480 | 9 |
| 2011-07-27 | vs BAL | 104 | W 3-0 | 52-52 | 4 | 16,861 | Ricky Romero | Alfredo Simon | Ricky Romero | Alfredo Simon | Jon Rauch | 492 | 480 | 12 |
| 2011-07-28 | vs BAL | 105 | W 8-5 | 53-52 | 4 | 16,152 | Carlos Villanueva | Brad Bergesen | Carlos Villanueva | Brad Bergesen | | 500 | 485 | 15 |
| 2011-07-29 | vs TEX | 106 | W 3-2 | 54-52 | 4 | 19,287 | Brett Cecil | Alexi Ogando | Brett Cecil | Alexi Ogando | Jon Rauch | 503 | 487 | 16 |
| 2011-07-30 | vs TEX | 107 | L 0-3 | 54-53 | 5 | 22,560 | Brad Mills | Derek Holland | Derek Holland | Brad Mills | | 503 | 490 | 13 |
| 2011-07-31 | vs TEX | 108 | W 7-3 | 55-53 | 4 | 45,629 | Brandon Morrow | C.J. Wilson | Brandon Morrow | C.J. Wilson | | 510 | 493 | 17 |
| 2011-08-02 | @ TBA | 109 | W 3-1 | 56-53 | 4 | 13,333 | Ricky Romero | David Price | Ricky Romero | David Price | Jon Rauch | 513 | 494 | 19 |
| 2011-08-03 | @ TBA | 110 | L 1-9 | 56-54 | 4 | 11,803 | Carlos Villanueva | James Shields | James Shields | Carlos Villanueva | | 514 | 503 | 11 |
| 2011-08-04 | @ TBA | 111 | L 6-7 | 56-55 | 4 | 28,491 | Brett Cecil | Wade Davis | Brandon Gomes | Shawn Camp | | 520 | 510 | 10 |
| 2011-08-05 | @ BAL | 112 | W 5-4 | 57-55 | 4 | 18,770 | Brad Mills | Tommy Hunter | Brad Mills | Tommy Hunter | Jon Rauch | 525 | 514 | 11 |
| 2011-08-06 | @ BAL | 113 | L 2-6 | 57-56 | 4 | 19,396 | Brandon Morrow | Chris Tillman | Chris Tillman | Brandon Morrow | | 527 | 520 | 7 |
| 2011-08-07 | @ BAL | 114 | W 7-2 | 58-56 | 4 | 13,824 | Ricky Romero | Alfredo Simon | Ricky Romero | Alfredo Simon | | 534 | 522 | 12 |
| 2011-08-09 | vs OAK | 115 | L 1-4 | 58-57 | 4 | 20,521 | Brett Cecil | Rich Harden | Rich Harden | Brett Cecil | Andrew Bailey | 535 | 526 | 9 |
| 2011-08-10 | vs OAK | 116 | W 8-4 | 59-57 | 4 | 19,541 | Henderson Alvarez | Gio Gonzalez | Casey Janssen | Gio Gonzalez | Jesse Litsch | 543 | 530 | 13 |
| 2011-08-11 | vs OAK | 117 | L 3-10 | 59-58 | 4 | 27,918 | Brad Mills | Guillermo Moscoso | Guillermo Moscoso | Brad Mills | | 546 | 540 | 6 |
| 2011-08-12 | vs ANA | 118 | L 1-5 | 59-59 | 4 | 24,731 | Brandon Morrow | Ervin Santana | Ervin Santana | Brandon Morrow | | 547 | 545 | 2 |
| 2011-08-13 | vs ANA | 119 | W 11-2 | 60-59 | 4 | 27,185 | Ricky Romero | Jered Weaver | Ricky Romero | Jered Weaver | | 558 | 547 | 11 |
| 2011-08-14 | vs ANA | 120 | W 5-4 | 61-59 | 4 | 23,355 | Brett Cecil | Dan Haren | Jon Rauch | Fernando Rodney | | 563 | 551 | 12 |
| 2011-08-15 | @ SEA | 121 | L 5-6 | 61-60 | 4 | 28,530 | Henderson Alvarez | Michael Pineda | Tom Wilhelmsen | Jon Rauch | Brandon League | 568 | 557 | 11 |
| 2011-08-16 | @ SEA | 122 | W 13-7 | 62-60 | 6 | 23,089 | Brad Mills | Jason Vargas | Luis Perez | Jason Vargas | | 581 | 564 | 17 |
| 2011-08-17 | @ SEA | 123 | W 5-1 | 63-60 | 4 | 26,579 | Brandon Morrow | Blake Beavan | Brandon Morrow | Blake Beavan | | 586 | 565 | 21 |
| 2011-08-18 | @ OAK | 124 | W 7-0 | 64-60 | 4 | 12,220 | Ricky Romero | Trevor Cahill | Ricky Romero | Trevor Cahill | | 593 | 565 | 28 |
| 2011-08-19 | @ OAK | 125 | L 0-2 | 64-61 | 4 | 13,174 | Brett Cecil | Rich Harden | Rich Harden | Brett Cecil | Andrew Bailey | 593 | 567 | 26 |
| 2011-08-20 | @ OAK | 126 | L 1-5 | 64-62 | 4 | 28,434 | Henderson Alvarez | Gio Gonzalez | Gio Gonzalez | Henderson Alvarez | | 594 | 572 | 22 |
| 2011-08-21 | @ OAK | 127 | W 1-0 | 65-62 | 4 | 16,811 | Luis Perez | Guillermo Moscoso | Luis Perez | Guillermo Moscoso | Casey Janssen | 595 | 572 | 23 |
| 2011-08-23 | vs KCA | 128 | L 4-6 | 65-63 | 4 | 20,009 | Brandon Morrow | Bruce Chen | Bruce Chen | Brandon Morrow | Joakim Soria | 599 | 578 | 21 |
| 2011-08-24 | vs KCA | 129 | W 4-3 | 66-63 | 4 | 18,292 | Ricky Romero | Luke Hochevar | Jesse Litsch | Louis Coleman | Frank Francisco | 603 | 581 | 22 |
| 2011-08-25 | vs KCA | 130 | L 6-9 | 66-64 | 4 | 17,355 | Brett Cecil | Jeff Francis | Jeff Francis | Brett Cecil | | 609 | 590 | 19 |
| 2011-08-26 | vs TBA | 131 | L 1-6 | 66-65 | 4 | 20,491 | Henderson Alvarez | James Shields | James Shields | Henderson Alvarez | | 610 | 596 | 14 |
| 2011-08-27 | vs TBA | 132 | L 5-6 | 66-66 | 5 | 24,052 | Luis Perez | Jeff Niemann | Jeff Niemann | Shawn Camp | Joel Peralta | 615 | 602 | 13 |
| 2011-08-28 | vs TBA | 133 | L 0-12 | 66-67 | 5 | 21,618 | Brandon Morrow | David Price | David Price | Brandon Morrow | | 615 | 614 | 1 |
| 2011-08-29 | vs TBA | 134 | W 7-3 | 67-67 | 4 | 19,725 | Ricky Romero | Wade Davis | Ricky Romero | Wade Davis | | 622 | 617 | 5 |
| 2011-08-30 | @ BAL | 135 | L 5-6 | 67-68 | 4 | 10,756 | Brett Cecil | Jeremy Guthrie | Willie Eyre | Brian Tallet | | 627 | 623 | 4 |
| 2011-08-31 | @ BAL | 136 | W 13-0 | 68-68 | 4 | 14,211 | Henderson Alvarez | Jo-Jo Reyes | Henderson Alvarez | Jo-Jo Reyes | | 640 | 623 | 17 |
| 2011-09-01 | @ BAL | 137 | W 8-6 | 69-68 | 4 | 11,617 | Luis Perez | Tommy Hunter | Shawn Camp | Willie Eyre | Frank Francisco | 648 | 629 | 19 |
| 2011-09-02 | @ NYA | 138 | L 2-3 | 69-69 | 4 | 47,240 | Brandon Morrow | Ivan Nova | Ivan Nova | Brandon Morrow | Mariano Rivera | 650 | 632 | 18 |
| 2011-09-03 | @ NYA | 139 | L 4-6 | 69-70 | 4 | 47,744 | Ricky Romero | Bartolo Colon | Boone Logan | Ricky Romero | David Robertson | 654 | 638 | 16 |
| 2011-09-04 | @ NYA | 140 | L 3-9 | 69-71 | 4 | 47,464 | Brett Cecil | CC Sabathia | CC Sabathia | Brett Cecil | | 657 | 647 | 10 |
| 2011-09-05 | vs BOS | 141 | W 1-0 | 70-71 | 4 | 27,573 | Henderson Alvarez | Josh Beckett | Shawn Camp | Dan Wheeler | | 658 | 647 | 11 |
| 2011-09-06 | vs BOS | 142 | L 0-14 | 70-72 | 4 | 17,565 | Luis Perez | Jon Lester | Jon Lester | Luis Perez | | 658 | 661 | -3 |
| 2011-09-07 | vs BOS | 143 | W 11-10 | 71-72 | 4 | 16,154 | Brandon Morrow | Tim Wakefield | Shawn Camp | Daniel Bard | Frank Francisco | 669 | 671 | -2 |
| 2011-09-08 | vs BOS | 144 | W 7-4 | 72-72 | 4 | 17,189 | Ricky Romero | Andrew Miller | Ricky Romero | Andrew Miller | | 676 | 675 | 1 |
| 2011-09-09 | vs BAL | 145 | L 0-2 | 72-73 | 4 | 13,918 | Brett Cecil | Jeremy Guthrie | Jeremy Guthrie | Brett Cecil | Jim Johnson | 676 | 677 | -1 |
| 2011-09-10 | vs BAL | 146 | W 5-4 | 73-73 | 4 | 17,742 | Henderson Alvarez | Rick Vanden Hurk | Jesse Litsch | Kevin Gregg | | 681 | 681 | 0 |
| 2011-09-11 | vs BAL | 147 | W 6-5 | 74-73 | 4 | 14,235 | Dustin McGowan | Tommy Hunter | Joel Carreno | Tommy Hunter | Frank Francisco | 687 | 686 | 1 |
| 2011-09-13 | @ BOS | 148 | L 6-18 | 74-74 | 4 | 38,020 | Brandon Morrow | Tim Wakefield | Tim Wakefield | Brandon Morrow | | 693 | 704 | -11 |
| 2011-09-14 | @ BOS | 149 | W 5-4 | 75-74 | 4 | 37,087 | Ricky Romero | John Lackey | Ricky Romero | Daniel Bard | Frank Francisco | 698 | 708 | -10 |
| 2011-09-16 | vs NYA | 150 | W 5-4 | 76-74 | 4 | 29,323 | Dustin McGowan | CC Sabathia | Casey Janssen | Boone Logan | | 703 | 712 | -9 |
| 2011-09-17 | vs NYA | 151 | L 6-7 | 76-75 | 4 | 39,288 | Henderson Alvarez | Bartolo Colon | Aaron Laffey | Carlos Villanueva | Mariano Rivera | 709 | 719 | -10 |
| 2011-09-18 | vs NYA | 152 | W 3-0 | 77-75 | 4 | 34,657 | Brandon Morrow | Freddy Garcia | Brandon Morrow | Freddy Garcia | Frank Francisco | 712 | 719 | -7 |
| 2011-09-19 | vs ANA | 153 | W 3-2 | 78-75 | 5 | 11,178 | Ricky Romero | Jerome Williams | Casey Janssen | Scott Downs | | 715 | 721 | -6 |
| 2011-09-20 | vs ANA | 154 | L 6-10 | 78-76 | 4 | 13,514 | Brett Cecil | Joel Pineiro | Joel Pineiro | Brett Cecil | Scott Downs | 721 | 731 | -10 |
| 2011-09-21 | vs ANA | 155 | L 2-7 | 78-77 | 6 | 14,784 | Dustin McGowan | Dan Haren | Dan Haren | Dustin McGowan | | 723 | 738 | -15 |
| 2011-09-22 | vs ANA | 156 | W 4-3 | 79-77 | 4 | 22,769 | Henderson Alvarez | Ervin Santana | Shawn Camp | Garrett Richards | | 727 | 741 | -14 |
| 2011-09-23 | @ TBA | 157 | W 5-1 | 80-77 | 4 | 18,093 | Brandon Morrow | David Price | Brandon Morrow | David Price | | 732 | 742 | -10 |
| 2011-09-24 | @ TBA | 158 | L 2-6 | 80-78 | 4 | 27,773 | Ricky Romero | Jeff Niemann | Alexander Torres | Ricky Romero | | 734 | 748 | -14 |
| 2011-09-25 | @ TBA | 159 | L 2-5 | 80-79 | 6 | 21,008 | Brett Cecil | Wade Davis | Wade Davis | Brett Cecil | Joel Peralta | 736 | 753 | -17 |
| 2011-09-26 | @ CHA | 160 | L 3-4 | 80-80 | 4 | 21,320 | Dustin McGowan | Dylan Axelrod | Dylan Axelrod | Dustin McGowan | Sergio Santos | 739 | 757 | -18 |
| 2011-09-27 | @ CHA | 161 | L 1-2 | 80-81 | 4 | 23,934 | Henderson Alvarez | Mark Buehrle | Mark Buehrle | Henderson Alvarez | Chris Sale | 740 | 759 | -19 |
| 2011-09-28 | @ CHA | 162 | W 3-2 | 81-81 | 4 | 20,524 | Brandon Morrow | Philip Humber | Shawn Camp | Chris Sale | Frank Francisco | 743 | 761 | -18 |