| Henderson Alvarez | 10 | 10 | 6 | 63.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 244 | 259 | 11 | 2 | 4 | 0 | 1 | 2 | 0 | 18 | 113 | 94 | 1.20 | 7 | 979 | 639 | 340 | 175 | 192 | 65 | 11 | 29 | 0 |
| Chad Beck | 3 | 0 | 0 | 0 | 3 | 2.3 | 8.0 | 0 | 0 | 1 | 0 | 3 | 0 | 0.0 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0.67 | 0 | 25 | 20 | 5 | 7 | 6 | 2 | 1 | 2 | 0 |
| Shawn Camp | 67 | 0 | 0 | 0 | 67 | 66.3 | 7.4 | 6 | 1 | 47 | 11 | 102 | 24 | 23.5 | 261 | 292 | 24 | 3 | 6 | 9 | 8 | 1 | 2 | 51 | 127 | 105 | 1.21 | 12 | 1003 | 634 | 369 | 152 | 171 | 79 | 11 | 21 | 0 |
| Joel Carreno | 11 | 0 | 0 | 0 | 11 | 15.7 | 7.3 | 0 | 0 | 5 | 0 | 12 | 0 | 0.0 | 55 | 59 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 9 | 22 | 19 | 1.16 | 2 | 221 | 136 | 85 | 25 | 49 | 21 | 5 | 9 | 3 |
| Brett Cecil | 20 | 20 | 9 | 123.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 476 | 532 | 24 | 3 | 6 | 1 | 4 | 2 | 0 | 38 | 160 | 237 | 0.68 | 5 | 1902 | 1224 | 678 | 338 | 329 | 160 | 15 | 72 | 10 |
| Octavio Dotel | 36 | 0 | 0 | 0 | 36 | 29.3 | 7.2 | 4 | 0 | 39 | 6 | 81 | 13 | 16.0 | 107 | 122 | 2 | 1 | 2 | 2 | 0 | 1 | 1 | 11 | 23 | 55 | 0.42 | 0 | 450 | 295 | 155 | 87 | 84 | 46 | 9 | 21 | 2 |
| Kyle Drabek | 18 | 14 | 6 | 72.7 | 4 | 6 | 7.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 301 | 365 | 20 | 1 | 1 | 0 | 8 | 3 | 5 | 60 | 117 | 141 | 0.83 | 9 | 1489 | 804 | 685 | 200 | 225 | 121 | 9 | 42 | 9 |
| Danny Farquhar | 3 | 0 | 0 | 0 | 3 | 2 | 8.0 | 0 | 0 | 2 | 1 | 6 | 3 | 50.0 | 8 | 11 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 0.33 | 1 | 46 | 30 | 16 | 6 | 14 | 2 | 0 | 1 | 0 |
| Frank Francisco | 54 | 0 | 0 | 0 | 54 | 50.7 | 8.7 | 3 | 3 | 13 | 1 | 27 | 2 | 7.4 | 199 | 218 | 12 | 0 | 0 | 2 | 13 | 1 | 0 | 2 | 58 | 89 | 0.65 | 2 | 882 | 575 | 307 | 156 | 173 | 99 | 11 | 42 | 1 |
| Jason Frasor | 44 | 0 | 0 | 0 | 44 | 42.3 | 7.2 | 8 | 2 | 33 | 6 | 66 | 13 | 19.7 | 156 | 178 | 10 | 2 | 2 | 1 | 6 | 2 | 2 | 42 | 51 | 73 | 0.70 | 6 | 756 | 469 | 287 | 144 | 148 | 53 | 13 | 24 | 1 |
| Casey Janssen | 55 | 0 | 0 | 0 | 55 | 55.7 | 7.5 | 6 | 1 | 27 | 10 | 57 | 20 | 35.1 | 206 | 223 | 11 | 0 | 2 | 1 | 2 | 2 | 2 | 25 | 75 | 79 | 0.95 | 4 | 874 | 563 | 311 | 151 | 185 | 73 | 19 | 34 | 2 |
| Wil Ledezma | 5 | 0 | 0 | 0 | 5 | 6 | 7.2 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 28 | 36 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 16 | 0.44 | 0 | 154 | 83 | 71 | 21 | 23 | 16 | 0 | 6 | 0 |
| Rommie Lewis | 6 | 0 | 0 | 0 | 6 | 5 | 6.2 | 0 | 0 | 6 | 2 | 15 | 6 | 40.0 | 27 | 31 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 8 | 15 | 0.53 | 0 | 141 | 90 | 51 | 35 | 22 | 11 | 1 | 4 | 1 |
| Jesse Litsch | 28 | 8 | 3 | 46.3 | 20 | 28.7 | 6.8 | 3 | 1 | 13 | 1 | 27 | 2 | 7.4 | 282 | 317 | 17 | 2 | 3 | 2 | 2 | 1 | 2 | 34 | 99 | 121 | 0.82 | 8 | 1273 | 770 | 503 | 193 | 238 | 119 | 20 | 46 | 10 |
| Mike McCoy | 1 | 0 | 0 | 0 | 1 | 1 | 9.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0.50 | 0 | 12 | 9 | 3 | 1 | 2 | 3 | 0 | 0 | 0 |
| Dustin McGowan | 5 | 4 | 0 | 17 | 1 | 4 | 5.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 81 | 96 | 4 | 1 | 1 | 0 | 4 | 0 | 1 | 9 | 30 | 31 | 0.97 | 0 | 377 | 214 | 163 | 62 | 57 | 33 | 3 | 17 | 3 |
| Trever Miller | 38 | 0 | 0 | 0 | 38 | 15.3 | 7.2 | 3 | 6 | 38 | 16 | 78 | 30 | 38.5 | 61 | 76 | 6 | 1 | 2 | 2 | 1 | 0 | 0 | 13 | 23 | 32 | 0.72 | 1 | 279 | 161 | 118 | 40 | 42 | 24 | 1 | 8 | 2 |
| Brad Mills | 5 | 4 | 1 | 18.3 | 1 | 0 | 8.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 77 | 91 | 5 | 1 | 2 | 1 | 0 | 0 | 0 | 11 | 20 | 39 | 0.51 | 1 | 374 | 226 | 148 | 66 | 69 | 32 | 5 | 13 | 4 |
| Brandon Morrow | 30 | 30 | 17 | 179.3 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 683 | 777 | 34 | 4 | 12 | 1 | 17 | 3 | 2 | 105 | 180 | 312 | 0.58 | 1 | 3130 | 1993 | 1137 | 616 | 511 | 373 | 40 | 163 | 12 |
| Luis Perez | 37 | 4 | 1 | 18.7 | 33 | 46.3 | 6.4 | 4 | 1 | 26 | 5 | 60 | 11 | 18.3 | 258 | 294 | 16 | 1 | 5 | 1 | 2 | 2 | 0 | 24 | 126 | 81 | 1.56 | 6 | 1094 | 672 | 422 | 192 | 194 | 78 | 16 | 38 | 2 |
| David Purcey | 5 | 0 | 0 | 0 | 5 | 2.3 | 8.0 | 0 | 1 | 0 | 0 | 0 | 0 | -- | 10 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 0.75 | 0 | 64 | 32 | 32 | 9 | 14 | 2 | 2 | 1 | 2 |
| Jon Rauch | 53 | 0 | 0 | 0 | 53 | 52 | 8.5 | 5 | 3 | 25 | 3 | 48 | 7 | 14.6 | 208 | 225 | 11 | 0 | 1 | 1 | 1 | 1 | 0 | 12 | 63 | 111 | 0.57 | 3 | 895 | 569 | 326 | 180 | 156 | 59 | 6 | 30 | 1 |
| Jo-Jo Reyes | 20 | 20 | 6 | 110 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 457 | 504 | 26 | 5 | 6 | 0 | 11 | 2 | 2 | 100 | 169 | 230 | 0.73 | 10 | 1839 | 1177 | 662 | 347 | 306 | 125 | 16 | 48 | 7 |
| Scott Richmond | 1 | 0 | 0 | 0 | 1 | 0.3 | 7.0 | 0 | 0 | 3 | 0 | 6 | 0 | 0.0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.00 | 0 | 6 | 3 | 3 | 0 | 0 | 2 | 0 | 0 | 0 |
| Ricky Romero | 32 | 32 | 25 | 225 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 816 | 917 | 38 | 3 | 14 | 2 | 18 | 7 | 7 | 94 | 360 | 286 | 1.26 | 28 | 3394 | 2063 | 1331 | 551 | 531 | 336 | 37 | 141 | 20 |
| Marc Rzepczynski | 43 | 0 | 0 | 0 | 43 | 39.3 | 7.4 | 10 | 4 | 17 | 4 | 39 | 9 | 23.1 | 139 | 158 | 6 | 0 | 3 | 0 | 1 | 1 | 1 | 18 | 70 | 37 | 1.89 | 7 | 565 | 338 | 227 | 68 | 95 | 68 | 7 | 26 | 5 |
| Zach Stewart | 10 | 8 | 3 | 46.3 | 2 | 4.3 | 4.0 | 0 | 0 | 2 | 0 | 6 | 0 | 0.0 | 204 | 222 | 14 | 1 | 1 | 1 | 6 | 1 | 2 | 71 | 89 | 82 | 1.09 | 6 | 821 | 523 | 298 | 131 | 160 | 60 | 10 | 25 | 0 |
| Brian Tallet | 16 | 0 | 0 | 0 | 16 | 12 | 7.3 | 2 | 1 | 9 | 1 | 21 | 3 | 14.3 | 56 | 65 | 5 | 1 | 2 | 1 | 1 | 0 | 0 | 8 | 26 | 25 | 1.04 | 0 | 253 | 152 | 101 | 47 | 34 | 20 | 2 | 7 | 0 |
| Carlos Villanueva | 33 | 13 | 5 | 73.3 | 20 | 33.7 | 6.0 | 0 | 2 | 15 | 4 | 30 | 9 | 30.0 | 411 | 454 | 18 | 3 | 4 | 3 | 13 | 0 | 0 | 97 | 128 | 222 | 0.58 | 9 | 1750 | 1075 | 675 | 259 | 327 | 139 | 7 | 61 | 5 |
| P.J. Walters | 4 | 0 | 0 | 0 | 4 | 4 | 7.5 | 0 | 0 | 1 | 0 | 3 | 0 | 0.0 | 16 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 8 | 0.63 | 0 | 82 | 53 | 29 | 21 | 11 | 8 | 1 | 2 | 1 |