| West | W | L | Pct | GB |
| Texas | 96 | 66 | .593 | -- |
| LA Angels | 86 | 76 | .531 | 10.0 |
| Oakland | 74 | 88 | .457 | 22.0 |
| Seattle | 67 | 95 | .414 | 29.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2011-04-01 | C.J. Wilson | L | 30 | L 9-5 | vs BOS | 1 | 40 | - | 5.2 | 6 | 4 | 2 | 0 | 2 | 6 | 109 | 39 | 70 | 64% | 0-0 | 3.00 | 1.33 |
| 2011-04-02 | Colby Lewis | R | 32 | L 12-5 | vs BOS | 1 | 67 | W | 6.0 | 6 | 3 | 3 | 1 | 2 | 4 | 105 | 43 | 62 | 59% | 1-0 | 4.50 | 1.33 |
| 2011-04-03 | Matt Harrison | L | 26 | L 5-1 | vs BOS | 1 | 33 | W | 7.0 | 5 | 1 | 1 | 0 | 2 | 8 | 108 | 37 | 71 | 66% | 1-0 | 1.29 | 1.00 |
| 2011-04-04 | Derek Holland | L | 24 | L 6-4 | vs SEA | 1 | 32 | W | 6.0 | 7 | 3 | 3 | 0 | 1 | 5 | 103 | 40 | 63 | 61% | 1-0 | 4.50 | 1.33 |
| 2011-04-05 | Alexi Ogando | R | 27 | L 3-2 | vs SEA | 1 | 1 | W | 6.0 | 2 | 0 | 0 | 0 | 2 | 4 | 90 | 35 | 55 | 61% | 1-0 | 0.00 | 0.67 |
| 2011-04-06 | C.J. Wilson | L | 30 | L 7-3 | vs SEA | 2 | 41 | W | 7.0 | 6 | 3 | 2 | 0 | 2 | 2 | 107 | 38 | 69 | 64% | 1-0 | 2.77 | 1.23 |
| 2011-04-09 | Colby Lewis | R | 32 | L 0-5 | @ BAL | 2 | 68 | L | 6.0 | 6 | 5 | 4 | 2 | 1 | 4 | 97 | 34 | 63 | 65% | 1-1 | 5.25 | 1.25 |
| 2011-04-09 | Matt Harrison | L | 26 | W 13-1 | @ BAL | 2 | 34 | W | 7.0 | 2 | 1 | 1 | 1 | 1 | 3 | 109 | 40 | 69 | 63% | 2-0 | 1.29 | 0.71 |
| 2011-04-10 | Derek Holland | L | 25 | W 3-0 | @ BAL | 2 | 33 | W | 6.0 | 5 | 0 | 0 | 0 | 2 | 6 | 109 | 42 | 67 | 61% | 2-0 | 2.25 | 1.25 |
| 2011-04-11 | Alexi Ogando | R | 28 | W 2-0 | @ DET | 2 | 2 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 4 | 79 | 26 | 53 | 67% | 2-0 | 0.00 | 0.54 |
| 2011-04-12 | C.J. Wilson | L | 30 | L 4-5 | @ DET | 3 | 42 | - | 6.2 | 7 | 4 | 4 | 0 | 3 | 4 | 106 | 40 | 66 | 62% | 1-0 | 3.79 | 1.37 |
| 2011-04-13 | David Bush | R | 31 | L 2-3 | @ DET | 1 | 185 | - | 3.0 | 3 | 0 | 0 | 0 | 3 | 0 | 73 | 22 | 51 | 70% | 0-0 | 0.00 | 2.00 |
| 2011-04-15 | Matt Harrison | L | 26 | W 5-3 | @ NYA | 3 | 35 | W | 8.0 | 7 | 2 | 1 | 1 | 3 | 3 | 103 | 45 | 58 | 56% | 3-0 | 1.23 | 0.91 |
| 2011-04-16 | Derek Holland | L | 25 | L 2-5 | @ NYA | 3 | 34 | L | 7.2 | 8 | 5 | 5 | 2 | 2 | 5 | 119 | 46 | 73 | 61% | 2-1 | 3.60 | 1.25 |
| 2011-04-17 | Alexi Ogando | R | 28 | L 5-6 | @ NYA | 3 | 3 | - | 6.1 | 6 | 5 | 5 | 3 | 1 | 1 | 90 | 34 | 56 | 62% | 2-0 | 2.37 | 0.74 |
| 2011-04-18 | C.J. Wilson | L | 30 | L 7-1 | vs ANA | 4 | 43 | W | 7.0 | 9 | 1 | 1 | 0 | 1 | 9 | 113 | 42 | 71 | 63% | 2-0 | 3.12 | 1.38 |
| 2011-04-19 | Colby Lewis | R | 32 | W 4-15 | vs ANA | 3 | 69 | L | 5.0 | 5 | 4 | 4 | 2 | 3 | 3 | 89 | 37 | 52 | 58% | 1-2 | 5.82 | 1.35 |
| 2011-04-20 | Matt Harrison | L | 26 | W 1-4 | vs ANA | 4 | 36 | L | 6.2 | 4 | 3 | 3 | 1 | 3 | 5 | 105 | 44 | 61 | 58% | 3-1 | 1.86 | 0.93 |
| 2011-04-22 | Derek Holland | L | 25 | L 11-6 | vs KCA | 4 | 35 | W | 7.0 | 7 | 5 | 5 | 1 | 2 | 9 | 106 | 34 | 72 | 68% | 3-1 | 4.33 | 1.26 |
| 2011-04-23 | Alexi Ogando | R | 28 | L 3-1 | vs KCA | 4 | 4 | W | 6.0 | 5 | 1 | 1 | 1 | 1 | 5 | 112 | 44 | 68 | 61% | 3-0 | 2.16 | 0.80 |
| 2011-04-24 | C.J. Wilson | L | 30 | L 8-7 | vs KCA | 5 | 44 | W | 7.0 | 8 | 4 | 4 | 2 | 1 | 10 | 111 | 43 | 68 | 61% | 3-0 | 3.55 | 1.36 |
| 2011-04-25 | Colby Lewis | R | 32 | W 4-6 | vs TOR | 4 | 70 | L | 5.0 | 7 | 6 | 6 | 3 | 4 | 3 | 93 | 35 | 58 | 62% | 1-3 | 6.95 | 1.55 |
| 2011-04-26 | Matt Harrison | L | 26 | W 3-10 | vs TOR | 5 | 37 | L | 3.0 | 8 | 7 | 7 | 1 | 3 | 1 | 60 | 24 | 36 | 60% | 3-2 | 3.66 | 1.19 |
| 2011-04-27 | Derek Holland | L | 25 | L 7-6 | vs TOR | 5 | 36 | - | 5.0 | 11 | 5 | 5 | 0 | 3 | 2 | 100 | 39 | 61 | 61% | 3-1 | 5.06 | 1.50 |
| 2011-04-28 | Alexi Ogando | R | 28 | W 2-5 | vs TOR | 5 | 5 | - | 6.0 | 4 | 2 | 2 | 1 | 3 | 7 | 94 | 42 | 52 | 55% | 3-0 | 2.32 | 0.87 |
| 2011-04-29 | C.J. Wilson | L | 30 | L 1-3 | @ OAK | 6 | 45 | L | 7.0 | 9 | 3 | 2 | 0 | 3 | 3 | 116 | 40 | 76 | 66% | 3-1 | 3.38 | 1.43 |
| 2011-04-30 | Colby Lewis | R | 32 | W 11-2 | @ OAK | 5 | 71 | W | 8.0 | 6 | 2 | 2 | 2 | 1 | 6 | 112 | 40 | 72 | 64% | 2-3 | 5.70 | 1.37 |
| 2011-05-01 | Matt Harrison | L | 26 | L 2-7 | @ OAK | 6 | 38 | L | 1.2 | 6 | 4 | 4 | 0 | 2 | 1 | 53 | 22 | 31 | 58% | 3-3 | 4.64 | 1.39 |
| 2011-05-02 | Derek Holland | L | 25 | L 4-5 | @ OAK | 6 | 37 | - | 7.0 | 8 | 3 | 2 | 1 | 2 | 4 | 103 | 32 | 71 | 69% | 3-1 | 4.62 | 1.49 |
| 2011-05-03 | Alexi Ogando | R | 28 | L 3-4 | @ SEA | 6 | 6 | - | 6.0 | 5 | 1 | 1 | 0 | 1 | 6 | 100 | 34 | 66 | 66% | 3-0 | 2.19 | 0.89 |
| 2011-05-04 | C.J. Wilson | L | 30 | W 5-2 | @ SEA | 7 | 46 | W | 9.0 | 6 | 2 | 1 | 0 | 1 | 12 | 130 | 47 | 83 | 64% | 4-1 | 2.94 | 1.31 |
| 2011-05-05 | Colby Lewis | R | 32 | L 1-3 | @ SEA | 6 | 72 | L | 8.0 | 8 | 3 | 3 | 1 | 1 | 11 | 115 | 30 | 85 | 74% | 2-4 | 5.21 | 1.32 |
| 2011-05-06 | Matt Harrison | L | 26 | W 1-4 | vs NYA | 7 | 39 | L | 6.0 | 4 | 3 | 2 | 1 | 5 | 3 | 117 | 52 | 65 | 56% | 3-4 | 4.38 | 1.41 |
| 2011-05-07 | Derek Holland | L | 25 | L 7-5 | vs NYA | 7 | 38 | - | 3.0 | 4 | 4 | 4 | 0 | 5 | 4 | 76 | 35 | 41 | 54% | 3-1 | 5.14 | 1.60 |
| 2011-05-08 | David Bush | R | 31 | W 5-12 | vs NYA | 2 | 186 | - | 4.0 | 5 | 3 | 2 | 1 | 0 | 2 | 67 | 25 | 42 | 63% | 0-0 | 2.25 | 1.25 |
| 2011-05-09 | C.J. Wilson | L | 30 | W 2-7 | vs OAK | 8 | 47 | L | 7.0 | 2 | 5 | 5 | 1 | 5 | 2 | 109 | 44 | 65 | 60% | 4-2 | 3.38 | 1.27 |
| 2011-05-10 | Colby Lewis | R | 32 | L 7-2 | vs OAK | 7 | 73 | W | 7.1 | 5 | 1 | 1 | 1 | 1 | 0 | 115 | 42 | 73 | 63% | 3-4 | 4.60 | 1.24 |
| 2011-05-13 | Alexi Ogando | R | 28 | L 4-1 | vs ANA | 7 | 7 | W | 6.1 | 5 | 1 | 1 | 1 | 1 | 5 | 96 | 37 | 59 | 61% | 4-0 | 2.05 | 0.89 |
| 2011-05-14 | Derek Holland | L | 25 | W 2-3 | vs ANA | 8 | 39 | - | 6.0 | 6 | 2 | 2 | 0 | 3 | 4 | 102 | 38 | 64 | 63% | 3-1 | 4.88 | 1.58 |
| 2011-05-15 | C.J. Wilson | L | 30 | L 5-4 | vs ANA | 9 | 48 | - | 5.0 | 6 | 4 | 2 | 1 | 4 | 2 | 102 | 39 | 63 | 62% | 4-2 | 3.39 | 1.33 |
| 2011-05-16 | Colby Lewis | R | 32 | W 4-0 | @ CHA | 8 | 74 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 7 | 110 | 36 | 74 | 67% | 4-4 | 3.83 | 1.15 |
| 2011-05-17 | Matt Harrison | L | 26 | L 3-4 | @ CHA | 8 | 40 | - | 7.0 | 3 | 3 | 3 | 1 | 4 | 6 | 108 | 45 | 63 | 58% | 3-4 | 4.30 | 1.35 |
| 2011-05-18 | Alexi Ogando | R | 28 | W 5-4 | @ KCA | 8 | 8 | - | 7.0 | 4 | 2 | 2 | 0 | 1 | 5 | 117 | 44 | 73 | 62% | 4-0 | 2.12 | 0.86 |
| 2011-05-19 | Derek Holland | L | 25 | L 1-2 | @ KCA | 9 | 40 | - | 8.0 | 9 | 1 | 1 | 0 | 1 | 5 | 116 | 40 | 76 | 66% | 3-1 | 4.34 | 1.54 |
| 2011-05-20 | C.J. Wilson | L | 30 | L 2-3 | @ PHI | 10 | 49 | L | 7.0 | 4 | 3 | 3 | 2 | 2 | 10 | 108 | 43 | 65 | 60% | 4-3 | 3.44 | 1.28 |
| 2011-05-21 | Colby Lewis | R | 32 | L 0-2 | @ PHI | 9 | 75 | L | 6.2 | 7 | 2 | 2 | 1 | 2 | 6 | 105 | 36 | 69 | 66% | 4-5 | 3.69 | 1.16 |
| 2011-05-22 | Matt Harrison | L | 26 | W 2-0 | @ PHI | 9 | 41 | W | 8.1 | 5 | 0 | 0 | 0 | 3 | 3 | 121 | 48 | 73 | 60% | 4-4 | 3.60 | 1.27 |
| 2011-05-23 | Alexi Ogando | R | 28 | L 4-0 | vs CHA | 9 | 9 | W | 9.0 | 5 | 0 | 0 | 0 | 3 | 6 | 115 | 39 | 76 | 66% | 5-0 | 1.80 | 0.87 |
| 2011-05-24 | Derek Holland | L | 25 | W 6-8 | vs CHA | 10 | 41 | - | 4.0 | 4 | 4 | 4 | 2 | 1 | 4 | 61 | 22 | 39 | 64% | 3-1 | 4.65 | 1.52 |
| 2011-05-25 | C.J. Wilson | L | 31 | L 2-1 | vs CHA | 11 | 50 | W | 6.1 | 5 | 1 | 1 | 0 | 0 | 5 | 103 | 41 | 62 | 60% | 5-3 | 3.24 | 1.23 |
| 2011-05-27 | Colby Lewis | R | 32 | W 7-12 | vs KCA | 10 | 76 | - | 6.0 | 7 | 6 | 4 | 0 | 2 | 3 | 107 | 31 | 76 | 71% | 4-5 | 3.90 | 1.19 |
| 2011-05-28 | Matt Harrison | L | 26 | L 10-1 | vs KCA | 10 | 42 | W | 6.0 | 5 | 0 | 0 | 0 | 1 | 1 | 99 | 32 | 67 | 68% | 5-4 | 3.25 | 1.25 |
| 2011-05-29 | Alexi Ogando | R | 28 | L 7-6 | vs KCA | 10 | 10 | - | 6.0 | 7 | 5 | 5 | 1 | 1 | 4 | 106 | 38 | 68 | 64% | 5-0 | 2.32 | 0.91 |
| 2011-05-30 | Derek Holland | L | 25 | W 11-5 | @ TBA | 11 | 42 | W | 5.2 | 5 | 5 | 5 | 2 | 5 | 7 | 112 | 48 | 64 | 57% | 4-1 | 4.98 | 1.55 |
| 2011-05-31 | C.J. Wilson | L | 31 | L 4-5 | @ TBA | 12 | 51 | - | 6.2 | 3 | 3 | 3 | 2 | 4 | 10 | 111 | 44 | 67 | 60% | 5-3 | 3.33 | 1.22 |
| 2011-06-01 | Colby Lewis | R | 32 | W 3-0 | @ TBA | 11 | 77 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 8 | 119 | 39 | 80 | 67% | 5-5 | 3.48 | 1.15 |
| 2011-06-02 | David Bush | R | 32 | W 7-4 | @ CLE | 3 | 187 | - | 4.0 | 4 | 3 | 3 | 0 | 1 | 3 | 81 | 32 | 49 | 60% | 0-1 | 4.88 | 1.38 |
| 2011-06-03 | Alexi Ogando | R | 28 | W 11-2 | @ CLE | 11 | 11 | W | 8.0 | 4 | 1 | 1 | 0 | 1 | 6 | 96 | 32 | 64 | 67% | 6-0 | 2.19 | 0.88 |
| 2011-06-04 | Derek Holland | L | 25 | W 4-0 | @ CLE | 12 | 43 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 5 | 112 | 35 | 77 | 69% | 5-1 | 4.38 | 1.45 |
| 2011-06-05 | C.J. Wilson | L | 31 | W 2-0 | @ CLE | 13 | 52 | W | 7.2 | 3 | 0 | 0 | 0 | 2 | 7 | 104 | 36 | 68 | 65% | 6-3 | 3.03 | 1.17 |
| 2011-06-06 | Colby Lewis | R | 32 | W 7-13 | vs DET | 12 | 78 | L | 3.1 | 10 | 9 | 9 | 4 | 1 | 3 | 87 | 33 | 54 | 62% | 5-6 | 4.38 | 1.24 |
| 2011-06-07 | Matt Harrison | L | 26 | W 1-8 | vs DET | 11 | 43 | L | 4.0 | 8 | 4 | 3 | 0 | 2 | 5 | 88 | 35 | 53 | 60% | 5-5 | 3.46 | 1.32 |
| 2011-06-08 | Alexi Ogando | R | 28 | L 7-3 | vs DET | 12 | 12 | W | 7.2 | 6 | 1 | 1 | 1 | 2 | 7 | 109 | 37 | 72 | 66% | 7-0 | 2.11 | 0.90 |
| 2011-06-09 | Derek Holland | L | 25 | L 4-5 | @ MIN | 13 | 44 | - | 7.1 | 8 | 4 | 4 | 2 | 1 | 10 | 111 | 32 | 79 | 71% | 5-1 | 4.39 | 1.41 |
| 2011-06-10 | C.J. Wilson | L | 31 | W 9-3 | @ MIN | 14 | 53 | W | 7.0 | 8 | 3 | 3 | 0 | 3 | 1 | 110 | 41 | 69 | 63% | 7-3 | 3.09 | 1.20 |
| 2011-06-11 | Colby Lewis | R | 32 | L 1-8 | @ MIN | 13 | 79 | L | 1.1 | 7 | 6 | 6 | 0 | 2 | 1 | 62 | 27 | 35 | 56% | 5-7 | 4.95 | 1.33 |
| 2011-06-12 | Matt Harrison | L | 26 | L 1-6 | @ MIN | 12 | 44 | L | 6.0 | 5 | 2 | 1 | 0 | 3 | 3 | 77 | 28 | 49 | 64% | 5-6 | 3.30 | 1.32 |
| 2011-06-14 | Alexi Ogando | R | 28 | L 4-12 | @ NYA | 13 | 13 | L | 1.2 | 6 | 6 | 6 | 0 | 1 | 1 | 53 | 21 | 32 | 60% | 7-1 | 2.71 | 0.96 |
| 2011-06-15 | Derek Holland | L | 25 | L 4-12 | @ NYA | 14 | 45 | L | 5.0 | 7 | 6 | 6 | 2 | 5 | 0 | 105 | 53 | 52 | 50% | 5-2 | 4.76 | 1.47 |
| 2011-06-16 | C.J. Wilson | L | 31 | L 2-3 | @ NYA | 15 | 54 | - | 8.0 | 7 | 2 | 2 | 0 | 3 | 10 | 129 | 48 | 81 | 63% | 7-3 | 3.03 | 1.20 |
| 2011-06-17 | Colby Lewis | R | 32 | W 6-2 | @ ATL | 14 | 80 | W | 6.2 | 5 | 2 | 2 | 2 | 3 | 10 | 117 | 46 | 71 | 61% | 6-7 | 4.81 | 1.33 |
| 2011-06-18 | Matt Harrison | L | 26 | W 5-4 | @ ATL | 13 | 45 | - | 6.1 | 3 | 3 | 1 | 1 | 1 | 6 | 101 | 35 | 66 | 65% | 5-6 | 3.16 | 1.27 |
| 2011-06-19 | Alexi Ogando | R | 28 | L 2-4 | @ ATL | 14 | 14 | L | 5.0 | 5 | 3 | 1 | 0 | 1 | 3 | 110 | 41 | 69 | 63% | 7-2 | 2.66 | 0.98 |
| 2011-06-20 | Derek Holland | L | 25 | L 8-3 | vs HOU | 15 | 46 | W | 7.1 | 6 | 3 | 3 | 0 | 3 | 4 | 110 | 39 | 71 | 65% | 6-2 | 4.69 | 1.46 |
| 2011-06-21 | C.J. Wilson | L | 31 | L 5-4 | vs HOU | 16 | 55 | - | 6.2 | 11 | 4 | 4 | 0 | 0 | 4 | 107 | 38 | 69 | 64% | 7-3 | 3.16 | 1.23 |
| 2011-06-22 | Colby Lewis | R | 32 | W 3-5 | vs HOU | 15 | 81 | - | 7.0 | 3 | 0 | 0 | 0 | 1 | 8 | 101 | 35 | 66 | 65% | 6-7 | 4.45 | 1.27 |
| 2011-06-24 | Matt Harrison | L | 26 | L 8-1 | vs NYN | 14 | 46 | W | 7.0 | 7 | 1 | 1 | 0 | 1 | 4 | 106 | 44 | 62 | 58% | 6-6 | 3.00 | 1.26 |
| 2011-06-25 | Alexi Ogando | R | 28 | W 5-14 | vs NYN | 15 | 15 | L | 3.0 | 8 | 6 | 3 | 0 | 0 | 1 | 76 | 28 | 48 | 63% | 7-3 | 2.87 | 1.03 |
| 2011-06-26 | Derek Holland | L | 25 | W 5-8 | vs NYN | 16 | 47 | L | 6.0 | 12 | 7 | 3 | 0 | 0 | 0 | 102 | 36 | 66 | 65% | 6-3 | 4.68 | 1.49 |
| 2011-06-28 | C.J. Wilson | L | 31 | W 7-3 | @ HOU | 17 | 56 | W | 7.0 | 7 | 2 | 2 | 0 | 2 | 3 | 106 | 44 | 62 | 58% | 8-3 | 3.13 | 1.23 |
| 2011-06-29 | Colby Lewis | R | 32 | W 3-2 | @ HOU | 16 | 82 | W | 6.2 | 6 | 2 | 2 | 1 | 0 | 6 | 74 | 13 | 61 | 82% | 7-7 | 4.32 | 1.24 |
| 2011-06-30 | Matt Harrison | L | 26 | L 0-7 | @ HOU | 15 | 47 | L | 6.0 | 7 | 5 | 5 | 1 | 2 | 2 | 110 | 42 | 68 | 62% | 6-7 | 3.30 | 1.28 |
| 2011-07-01 | Alexi Ogando | R | 28 | L 15-5 | vs FLO | 16 | 16 | W | 6.2 | 5 | 2 | 2 | 0 | 2 | 8 | 100 | 27 | 73 | 73% | 8-3 | 2.85 | 1.03 |
| 2011-07-02 | Derek Holland | L | 25 | W 5-9 | vs FLO | 17 | 48 | L | 0.2 | 4 | 5 | 5 | 1 | 2 | 1 | 46 | 19 | 27 | 59% | 6-4 | 5.08 | 1.53 |
| 2011-07-03 | C.J. Wilson | L | 31 | W 4-6 | vs FLO | 18 | 57 | - | 7.1 | 5 | 2 | 2 | 0 | 1 | 9 | 96 | 30 | 66 | 69% | 8-3 | 3.10 | 1.21 |
| 2011-07-04 | Colby Lewis | R | 32 | L 13-4 | vs BAL | 17 | 83 | W | 7.0 | 5 | 3 | 3 | 2 | 3 | 4 | 110 | 40 | 70 | 64% | 8-7 | 4.29 | 1.23 |
| 2011-07-05 | Matt Harrison | L | 26 | L 4-2 | vs BAL | 16 | 48 | - | 6.0 | 11 | 2 | 2 | 2 | 0 | 5 | 103 | 38 | 65 | 63% | 6-7 | 3.28 | 1.31 |
| 2011-07-06 | Alexi Ogando | R | 28 | L 13-5 | vs BAL | 17 | 17 | W | 7.0 | 4 | 3 | 3 | 2 | 1 | 5 | 100 | 36 | 64 | 64% | 9-3 | 2.91 | 1.01 |
| 2011-07-07 | Derek Holland | L | 25 | L 6-0 | vs OAK | 18 | 49 | W | 9.0 | 4 | 0 | 0 | 0 | 2 | 7 | 119 | 38 | 81 | 68% | 7-4 | 4.66 | 1.46 |
| 2011-07-08 | C.J. Wilson | L | 31 | L 8-5 | vs OAK | 19 | 58 | W | 7.0 | 5 | 4 | 4 | 1 | 3 | 8 | 102 | 39 | 63 | 62% | 9-3 | 3.20 | 1.20 |
| 2011-07-09 | Colby Lewis | R | 32 | L 7-6 | vs OAK | 18 | 84 | - | 6.0 | 5 | 5 | 4 | 1 | 3 | 9 | 105 | 35 | 70 | 67% | 8-7 | 4.38 | 1.24 |
| 2011-07-10 | Matt Harrison | L | 26 | L 2-0 | vs OAK | 17 | 49 | W | 7.2 | 6 | 0 | 0 | 0 | 1 | 7 | 111 | 41 | 70 | 63% | 7-7 | 3.03 | 1.28 |
| 2011-07-14 | Derek Holland | L | 25 | W 5-0 | @ SEA | 19 | 50 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 8 | 120 | 41 | 79 | 66% | 8-4 | 4.31 | 1.40 |
| 2011-07-15 | Colby Lewis | R | 32 | W 4-0 | @ SEA | 19 | 85 | W | 8.2 | 4 | 0 | 0 | 0 | 2 | 8 | 119 | 35 | 84 | 71% | 9-7 | 4.06 | 1.20 |
| 2011-07-16 | C.J. Wilson | L | 31 | W 5-1 | @ SEA | 20 | 59 | W | 7.0 | 5 | 1 | 1 | 0 | 3 | 7 | 109 | 42 | 67 | 61% | 10-3 | 3.11 | 1.20 |
| 2011-07-17 | Matt Harrison | L | 26 | W 3-1 | @ SEA | 18 | 50 | W | 7.2 | 5 | 1 | 1 | 0 | 1 | 4 | 106 | 40 | 66 | 62% | 8-7 | 2.92 | 1.25 |
| 2011-07-19 | Alexi Ogando | R | 28 | W 7-0 | @ ANA | 18 | 18 | W | 8.0 | 4 | 0 | 0 | 0 | 3 | 5 | 126 | 48 | 78 | 62% | 10-3 | 2.71 | 1.00 |
| 2011-07-20 | Derek Holland | L | 25 | L 8-9 | @ ANA | 20 | 51 | - | 5.1 | 9 | 7 | 7 | 1 | 3 | 4 | 103 | 32 | 71 | 69% | 8-4 | 4.65 | 1.44 |
| 2011-07-21 | C.J. Wilson | L | 31 | L 0-1 | @ ANA | 21 | 60 | L | 8.0 | 2 | 1 | 0 | 0 | 1 | 8 | 111 | 39 | 72 | 65% | 10-4 | 2.94 | 1.16 |
| 2011-07-22 | Colby Lewis | R | 32 | L 12-2 | vs TOR | 20 | 86 | W | 6.2 | 2 | 1 | 1 | 1 | 2 | 5 | 103 | 39 | 64 | 62% | 10-7 | 3.94 | 1.17 |
| 2011-07-23 | Matt Harrison | L | 26 | L 5-4 | vs TOR | 19 | 51 | - | 6.2 | 8 | 4 | 4 | 1 | 0 | 8 | 99 | 39 | 60 | 61% | 8-7 | 3.05 | 1.25 |
| 2011-07-24 | Alexi Ogando | R | 28 | W 0-3 | vs TOR | 19 | 19 | L | 6.2 | 7 | 3 | 3 | 0 | 2 | 6 | 103 | 34 | 69 | 67% | 10-4 | 2.80 | 1.03 |
| 2011-07-25 | Derek Holland | L | 25 | L 20-6 | vs MIN | 21 | 52 | W | 6.0 | 5 | 1 | 0 | 0 | 0 | 4 | 90 | 27 | 63 | 70% | 9-4 | 4.43 | 1.42 |
| 2011-07-26 | C.J. Wilson | L | 31 | W 8-9 | vs MIN | 22 | 61 | - | 4.0 | 7 | 6 | 5 | 0 | 4 | 3 | 81 | 32 | 49 | 60% | 10-4 | 3.16 | 1.20 |
| 2011-07-27 | Colby Lewis | R | 32 | W 2-7 | vs MIN | 21 | 87 | L | 6.2 | 8 | 4 | 4 | 2 | 2 | 5 | 105 | 37 | 68 | 65% | 10-8 | 4.00 | 1.19 |
| 2011-07-28 | Matt Harrison | L | 26 | L 4-1 | vs MIN | 20 | 52 | W | 7.1 | 8 | 1 | 1 | 0 | 1 | 2 | 114 | 47 | 67 | 59% | 9-7 | 2.95 | 1.25 |
| 2011-07-29 | Alexi Ogando | R | 28 | L 2-3 | @ TOR | 20 | 20 | L | 5.2 | 4 | 3 | 3 | 1 | 4 | 4 | 103 | 41 | 62 | 60% | 10-5 | 2.88 | 1.04 |
| 2011-07-30 | Derek Holland | L | 25 | W 3-0 | @ TOR | 22 | 53 | W | 9.0 | 4 | 0 | 0 | 0 | 1 | 5 | 95 | 26 | 69 | 73% | 10-4 | 4.14 | 1.36 |
| 2011-07-31 | C.J. Wilson | L | 31 | L 3-7 | @ TOR | 23 | 62 | L | 3.2 | 7 | 7 | 5 | 1 | 3 | 2 | 90 | 45 | 45 | 50% | 10-5 | 3.37 | 1.23 |
| 2011-08-02 | Colby Lewis | R | 32 | L 5-6 | @ DET | 22 | 88 | - | 4.0 | 10 | 5 | 4 | 1 | 3 | 3 | 83 | 33 | 50 | 60% | 10-8 | 4.14 | 1.24 |
| 2011-08-03 | Matt Harrison | L | 26 | L 4-5 | @ DET | 21 | 53 | L | 6.0 | 9 | 4 | 4 | 1 | 3 | 3 | 109 | 45 | 64 | 59% | 9-8 | 3.09 | 1.28 |
| 2011-08-04 | Alexi Ogando | R | 28 | W 5-2 | @ DET | 21 | 21 | W | 6.1 | 8 | 2 | 2 | 0 | 0 | 7 | 97 | 28 | 69 | 71% | 11-5 | 2.89 | 1.05 |
| 2011-08-05 | Derek Holland | L | 25 | L 8-7 | vs CLE | 23 | 54 | - | 1.2 | 5 | 6 | 4 | 1 | 1 | 1 | 53 | 19 | 34 | 64% | 10-4 | 4.34 | 1.38 |
| 2011-08-06 | C.J. Wilson | L | 31 | W 5-7 | vs CLE | 24 | 63 | - | 6.2 | 5 | 3 | 2 | 0 | 2 | 9 | 111 | 43 | 68 | 61% | 10-5 | 3.35 | 1.23 |
| 2011-08-07 | Colby Lewis | R | 32 | L 5-3 | vs CLE | 23 | 89 | - | 7.1 | 5 | 3 | 3 | 1 | 1 | 3 | 107 | 38 | 69 | 64% | 10-8 | 4.13 | 1.23 |
| 2011-08-08 | Matt Harrison | L | 26 | L 9-2 | vs SEA | 22 | 54 | W | 7.0 | 5 | 2 | 2 | 0 | 0 | 6 | 101 | 40 | 61 | 60% | 10-8 | 3.07 | 1.25 |
| 2011-08-09 | Alexi Ogando | R | 28 | L 7-6 | vs SEA | 22 | 22 | - | 2.2 | 8 | 6 | 6 | 0 | 2 | 0 | 70 | 28 | 42 | 60% | 11-5 | 3.22 | 1.10 |
| 2011-08-10 | Derek Holland | L | 25 | W 3-4 | vs SEA | 24 | 55 | - | 6.0 | 7 | 3 | 2 | 1 | 5 | 7 | 116 | 49 | 67 | 58% | 10-4 | 4.29 | 1.41 |
| 2011-08-12 | C.J. Wilson | L | 31 | W 9-1 | @ OAK | 25 | 64 | W | 6.0 | 4 | 1 | 1 | 0 | 3 | 7 | 114 | 43 | 71 | 62% | 11-5 | 3.29 | 1.23 |
| 2011-08-13 | Colby Lewis | R | 32 | W 7-1 | @ OAK | 24 | 90 | W | 6.1 | 3 | 1 | 1 | 0 | 0 | 8 | 101 | 30 | 71 | 70% | 11-8 | 4.00 | 1.19 |
| 2011-08-14 | Matt Harrison | L | 26 | W 7-6 | @ OAK | 23 | 55 | - | 5.1 | 6 | 6 | 4 | 0 | 3 | 6 | 113 | 43 | 70 | 62% | 10-8 | 3.19 | 1.26 |
| 2011-08-15 | Alexi Ogando | R | 28 | W 8-4 | @ ANA | 23 | 23 | W | 6.1 | 8 | 4 | 4 | 1 | 2 | 2 | 103 | 40 | 63 | 61% | 12-5 | 3.34 | 1.13 |
| 2011-08-16 | Derek Holland | L | 25 | W 7-3 | @ ANA | 25 | 56 | W | 8.2 | 9 | 3 | 3 | 0 | 1 | 7 | 121 | 41 | 80 | 66% | 11-4 | 4.24 | 1.40 |
| 2011-08-17 | C.J. Wilson | L | 31 | W 4-3 | @ ANA | 26 | 65 | W | 7.0 | 5 | 2 | 1 | 0 | 1 | 6 | 111 | 36 | 75 | 68% | 12-5 | 3.21 | 1.21 |
| 2011-08-18 | Colby Lewis | R | 32 | L 1-2 | @ ANA | 25 | 91 | - | 7.0 | 4 | 0 | 0 | 0 | 2 | 7 | 115 | 41 | 74 | 64% | 11-8 | 3.83 | 1.18 |
| 2011-08-19 | Matt Harrison | L | 26 | W 7-4 | @ CHA | 24 | 56 | - | 4.1 | 4 | 4 | 3 | 0 | 3 | 4 | 83 | 40 | 43 | 52% | 10-8 | 3.28 | 1.28 |
| 2011-08-20 | Alexi Ogando | R | 28 | L 2-3 | @ CHA | 24 | 24 | - | 7.0 | 6 | 2 | 2 | 0 | 1 | 5 | 103 | 40 | 63 | 61% | 12-5 | 3.31 | 1.12 |
| 2011-08-21 | Derek Holland | L | 25 | L 0-10 | @ CHA | 26 | 57 | L | 3.1 | 8 | 5 | 5 | 1 | 2 | 3 | 84 | 31 | 53 | 63% | 11-5 | 4.42 | 1.43 |
| 2011-08-22 | C.J. Wilson | L | 31 | L 4-0 | vs BOS | 27 | 66 | W | 6.2 | 4 | 0 | 0 | 0 | 2 | 4 | 110 | 40 | 70 | 64% | 13-5 | 3.08 | 1.20 |
| 2011-08-23 | Colby Lewis | R | 32 | W 5-11 | vs BOS | 26 | 92 | L | 6.0 | 9 | 7 | 7 | 2 | 2 | 2 | 102 | 40 | 62 | 61% | 11-9 | 4.07 | 1.20 |
| 2011-08-24 | Matt Harrison | L | 26 | W 2-13 | vs BOS | 25 | 57 | L | 5.0 | 11 | 7 | 7 | 0 | 1 | 4 | 93 | 29 | 64 | 69% | 10-9 | 3.59 | 1.31 |
| 2011-08-25 | Alexi Ogando | R | 28 | W 0-6 | vs BOS | 25 | 25 | L | 4.0 | 6 | 6 | 6 | 4 | 1 | 5 | 76 | 29 | 47 | 62% | 12-6 | 3.58 | 1.14 |
| 2011-08-26 | Derek Holland | L | 25 | L 11-7 | vs ANA | 27 | 58 | W | 6.2 | 8 | 1 | 1 | 0 | 2 | 6 | 115 | 43 | 72 | 63% | 12-5 | 4.31 | 1.44 |
| 2011-08-27 | C.J. Wilson | L | 31 | W 4-8 | vs ANA | 28 | 67 | L | 5.0 | 10 | 6 | 6 | 4 | 1 | 2 | 97 | 39 | 58 | 60% | 13-6 | 3.29 | 1.23 |
| 2011-08-28 | Colby Lewis | R | 32 | L 9-5 | vs ANA | 27 | 93 | - | 6.0 | 8 | 5 | 5 | 1 | 1 | 3 | 103 | 37 | 66 | 64% | 11-9 | 4.19 | 1.21 |
| 2011-08-30 | Scott Feldman | R | 29 | L 2-0 | vs TBA | 1 | 79 | W | 6.0 | 2 | 0 | 0 | 0 | 1 | 4 | 88 | 35 | 53 | 60% | 1-0 | 2.86 | 0.95 |
| 2011-08-31 | Alexi Ogando | R | 28 | W 1-4 | vs TBA | 26 | 26 | L | 2.2 | 5 | 3 | 3 | 0 | 2 | 3 | 54 | 22 | 32 | 59% | 12-7 | 3.68 | 1.16 |
| 2011-09-01 | C.J. Wilson | L | 31 | L 7-2 | vs TBA | 29 | 68 | W | 6.0 | 2 | 2 | 2 | 1 | 1 | 8 | 88 | 35 | 53 | 60% | 14-6 | 3.28 | 1.20 |
| 2011-09-02 | Derek Holland | L | 25 | W 10-0 | @ BOS | 28 | 59 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 6 | 100 | 38 | 62 | 62% | 13-5 | 4.13 | 1.39 |
| 2011-09-03 | Colby Lewis | R | 32 | L 7-12 | @ BOS | 28 | 94 | L | 3.1 | 7 | 4 | 4 | 1 | 3 | 3 | 89 | 36 | 53 | 60% | 11-10 | 4.32 | 1.25 |
| 2011-09-04 | Matt Harrison | L | 26 | W 11-4 | @ BOS | 26 | 58 | W | 7.0 | 7 | 2 | 2 | 0 | 2 | 5 | 114 | 49 | 65 | 57% | 11-9 | 3.50 | 1.30 |
| 2011-09-05 | Scott Feldman | R | 29 | L 1-5 | @ TBA | 2 | 80 | L | 5.0 | 4 | 4 | 4 | 1 | 4 | 2 | 102 | 44 | 58 | 57% | 1-1 | 3.67 | 1.07 |
| 2011-09-06 | C.J. Wilson | L | 31 | W 8-0 | @ TBA | 30 | 69 | W | 9.0 | 5 | 0 | 0 | 0 | 3 | 6 | 116 | 44 | 72 | 62% | 15-6 | 3.13 | 1.19 |
| 2011-09-07 | Derek Holland | L | 25 | L 4-5 | @ TBA | 29 | 60 | - | 6.2 | 6 | 4 | 3 | 1 | 3 | 9 | 106 | 40 | 66 | 62% | 13-5 | 4.12 | 1.39 |
| 2011-09-09 | Colby Lewis | R | 32 | L 13-4 | vs OAK | 29 | 95 | W | 7.1 | 5 | 3 | 3 | 1 | 1 | 7 | 99 | 31 | 68 | 69% | 12-10 | 4.30 | 1.23 |
| 2011-09-10 | Alexi Ogando | R | 28 | W 7-8 | vs OAK | 27 | 27 | L | 5.0 | 6 | 5 | 3 | 0 | 1 | 3 | 85 | 37 | 48 | 56% | 12-8 | 3.71 | 1.17 |
| 2011-09-11 | C.J. Wilson | L | 31 | L 8-1 | vs OAK | 31 | 70 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 11 | 110 | 37 | 73 | 66% | 16-6 | 3.01 | 1.17 |
| 2011-09-13 | Matt Harrison | L | 26 | L 10-4 | vs CLE | 27 | 59 | W | 5.0 | 7 | 3 | 3 | 1 | 1 | 4 | 94 | 32 | 62 | 66% | 12-9 | 3.56 | 1.31 |
| 2011-09-14 | Derek Holland | L | 25 | L 9-1 | vs CLE | 30 | 61 | W | 7.0 | 6 | 1 | 1 | 1 | 3 | 6 | 106 | 38 | 68 | 64% | 14-5 | 4.02 | 1.38 |
| 2011-09-15 | Alexi Ogando | R | 28 | L 7-4 | vs CLE | 28 | 28 | W | 6.0 | 2 | 0 | 0 | 0 | 2 | 4 | 90 | 31 | 59 | 66% | 13-8 | 3.58 | 1.15 |
| 2011-09-16 | C.J. Wilson | L | 31 | L 0-4 | @ SEA | 32 | 71 | L | 6.1 | 6 | 4 | 1 | 1 | 2 | 8 | 119 | 48 | 71 | 60% | 16-7 | 2.97 | 1.18 |
| 2011-09-17 | Colby Lewis | R | 32 | W 7-6 | @ SEA | 30 | 96 | W | 5.2 | 8 | 6 | 6 | 1 | 1 | 7 | 94 | 28 | 66 | 70% | 13-10 | 4.45 | 1.24 |
| 2011-09-18 | Matt Harrison | L | 26 | W 3-0 | @ SEA | 28 | 60 | W | 6.2 | 6 | 0 | 0 | 0 | 2 | 9 | 114 | 40 | 74 | 65% | 13-9 | 3.41 | 1.30 |
| 2011-09-20 | Derek Holland | L | 25 | W 7-2 | @ OAK | 31 | 62 | W | 7.0 | 2 | 1 | 1 | 1 | 3 | 7 | 106 | 45 | 61 | 58% | 15-5 | 3.92 | 1.36 |
| 2011-09-21 | C.J. Wilson | L | 31 | W 3-2 | @ OAK | 33 | 72 | - | 6.0 | 5 | 2 | 2 | 0 | 3 | 8 | 112 | 44 | 68 | 61% | 16-7 | 2.97 | 1.18 |
| 2011-09-22 | Colby Lewis | R | 32 | L 3-4 | @ OAK | 31 | 97 | - | 6.1 | 4 | 3 | 3 | 1 | 2 | 7 | 100 | 38 | 62 | 62% | 13-10 | 4.45 | 1.23 |
| 2011-09-23 | Matt Harrison | L | 26 | L 5-3 | vs SEA | 29 | 61 | W | 6.0 | 3 | 3 | 3 | 0 | 2 | 1 | 89 | 32 | 57 | 64% | 14-9 | 3.45 | 1.28 |
| 2011-09-24 | Alexi Ogando | R | 28 | L 7-3 | vs SEA | 29 | 29 | - | 2.0 | 0 | 0 | 0 | 0 | 0 | 2 | 28 | 10 | 18 | 64% | 13-8 | 3.54 | 1.14 |
| 2011-09-25 | Derek Holland | L | 25 | L 12-5 | vs SEA | 32 | 63 | W | 5.0 | 5 | 3 | 3 | 2 | 1 | 7 | 74 | 20 | 54 | 73% | 16-5 | 3.95 | 1.35 |
| 2011-09-26 | C.J. Wilson | L | 31 | W 4-3 | @ ANA | 34 | 73 | - | 2.0 | 2 | 0 | 0 | 0 | 2 | 0 | 41 | 20 | 21 | 51% | 16-7 | 2.95 | 1.19 |
| 2011-09-27 | Colby Lewis | R | 32 | W 10-3 | @ ANA | 32 | 98 | W | 6.0 | 3 | 2 | 2 | 0 | 1 | 5 | 81 | 30 | 51 | 63% | 14-10 | 4.41 | 1.22 |
| 2011-09-28 | Matt Harrison | L | 26 | W 3-1 | @ ANA | 30 | 62 | - | 6.0 | 5 | 1 | 1 | 0 | 1 | 4 | 87 | 30 | 57 | 66% | 14-9 | 3.39 | 1.27 |