| 2011-04-01 | vs BOS | 1 | W 9-5 | 1-0 | 2 | 50,146 | C.J. Wilson | Jon Lester | Darren Oliver | Daniel Bard | | 9 | 5 | 4 |
| 2011-04-02 | vs BOS | 2 | W 12-5 | 2-0 | 2 | 48,356 | Colby Lewis | John Lackey | Colby Lewis | John Lackey | | 21 | 10 | 11 |
| 2011-04-03 | vs BOS | 3 | W 5-1 | 3-0 | 1 | 46,326 | Matt Harrison | Clay Buchholz | Matt Harrison | Clay Buchholz | | 26 | 11 | 15 |
| 2011-04-04 | vs SEA | 4 | W 6-4 | 4-0 | 1 | 37,618 | Derek Holland | Erik Bedard | Derek Holland | Erik Bedard | Neftali Feliz | 32 | 15 | 17 |
| 2011-04-05 | vs SEA | 5 | W 3-2 | 5-0 | 1 | 30,953 | Alexi Ogando | Michael Pineda | Alexi Ogando | Michael Pineda | Neftali Feliz | 35 | 17 | 18 |
| 2011-04-06 | vs SEA | 6 | W 7-3 | 6-0 | 1 | 25,049 | C.J. Wilson | Felix Hernandez | C.J. Wilson | Felix Hernandez | | 42 | 20 | 22 |
| 2011-04-09 | @ BAL | 7 | L 0-5 | 6-1 | 2 | 0 | Colby Lewis | Zachary Britton | Zachary Britton | Colby Lewis | | 42 | 25 | 17 |
| 2011-04-09 | @ BAL | 8 | W 13-1 | 6-1 | 2 | 36,243 | Matt Harrison | Jake Arrieta | Matt Harrison | Jake Arrieta | | 55 | 26 | 29 |
| 2011-04-10 | @ BAL | 9 | W 3-0 | 8-1 | 1 | 21,452 | Derek Holland | Jeremy Guthrie | Derek Holland | Jeremy Guthrie | Neftali Feliz | 58 | 26 | 32 |
| 2011-04-11 | @ DET | 10 | W 2-0 | 9-1 | 1 | 18,724 | Alexi Ogando | Justin Verlander | Alexi Ogando | Justin Verlander | Neftali Feliz | 60 | 26 | 34 |
| 2011-04-12 | @ DET | 11 | L 4-5 | 9-2 | 1 | 20,609 | C.J. Wilson | Brad Penny | Jose Valverde | Darren O'Day | | 64 | 31 | 33 |
| 2011-04-13 | @ DET | 12 | L 2-3 | 9-3 | 1 | 20,526 | David Bush | Max Scherzer | Jose Valverde | Darren Oliver | | 66 | 34 | 32 |
| 2011-04-15 | @ NYA | 13 | W 5-3 | 10-3 | 1 | 40,814 | Matt Harrison | Ivan Nova | Matt Harrison | Ivan Nova | Neftali Feliz | 71 | 37 | 34 |
| 2011-04-16 | @ NYA | 14 | L 2-5 | 10-4 | 1 | 41,876 | Derek Holland | Freddy Garcia | Freddy Garcia | Derek Holland | Mariano Rivera | 73 | 42 | 31 |
| 2011-04-17 | @ NYA | 15 | L 5-6 | 10-5 | 2 | 40,811 | Alexi Ogando | CC Sabathia | Rafael Soriano | Arthur Rhodes | Mariano Rivera | 78 | 48 | 30 |
| 2011-04-18 | vs ANA | 16 | W 7-1 | 11-5 | 1 | 30,799 | C.J. Wilson | Ervin Santana | C.J. Wilson | Ervin Santana | | 85 | 49 | 36 |
| 2011-04-19 | vs ANA | 17 | L 4-15 | 11-6 | 2 | 22,450 | Colby Lewis | Matt Palmer | Matt Palmer | Colby Lewis | | 89 | 64 | 25 |
| 2011-04-20 | vs ANA | 18 | L 1-4 | 11-7 | 2 | 31,967 | Matt Harrison | Jered Weaver | Jered Weaver | Matt Harrison | | 90 | 68 | 22 |
| 2011-04-22 | vs KCA | 19 | W 11-6 | 12-7 | 1 | 45,769 | Derek Holland | Jeff Francis | Derek Holland | Jeff Francis | | 101 | 74 | 27 |
| 2011-04-23 | vs KCA | 20 | W 3-1 | 13-7 | 1 | 45,506 | Alexi Ogando | Kyle Davies | Alexi Ogando | Kyle Davies | Darren Oliver | 104 | 75 | 29 |
| 2011-04-24 | vs KCA | 21 | W 8-7 | 14-7 | 1 | 28,284 | C.J. Wilson | Bruce Chen | C.J. Wilson | Bruce Chen | Arthur Rhodes | 112 | 82 | 30 |
| 2011-04-25 | vs TOR | 22 | L 4-6 | 14-8 | 1 | 22,915 | Colby Lewis | Kyle Drabek | Kyle Drabek | Colby Lewis | Jon Rauch | 116 | 88 | 28 |
| 2011-04-26 | vs TOR | 23 | L 3-10 | 14-9 | 1 | 21,755 | Matt Harrison | Jesse Litsch | Jesse Litsch | Matt Harrison | | 119 | 98 | 21 |
| 2011-04-27 | vs TOR | 24 | W 7-6 | 15-9 | 1 | 29,322 | Derek Holland | Jo-Jo Reyes | Cody Eppley | Octavio Dotel | Darren Oliver | 126 | 104 | 22 |
| 2011-04-28 | vs TOR | 25 | L 2-5 | 15-10 | 1 | 24,121 | Alexi Ogando | Brandon Morrow | Frank Francisco | Darren Oliver | | 128 | 109 | 19 |
| 2011-04-29 | @ OAK | 26 | L 1-3 | 15-11 | 2 | 17,226 | C.J. Wilson | Trevor Cahill | Trevor Cahill | C.J. Wilson | Brian Fuentes | 129 | 112 | 17 |
| 2011-04-30 | @ OAK | 27 | W 11-2 | 16-11 | 1 | 27,285 | Colby Lewis | Brett Anderson | Colby Lewis | Brett Anderson | | 140 | 114 | 26 |
| 2011-05-01 | @ OAK | 28 | L 2-7 | 16-12 | 2 | 15,178 | Matt Harrison | Gio Gonzalez | Gio Gonzalez | Matt Harrison | | 142 | 121 | 21 |
| 2011-05-02 | @ OAK | 29 | L 4-5 | 16-13 | 2 | 9,193 | Derek Holland | Brandon McCarthy | Grant Balfour | Darren Oliver | | 146 | 126 | 20 |
| 2011-05-03 | @ SEA | 30 | L 3-4 | 16-14 | 2 | 12,759 | Alexi Ogando | Erik Bedard | David Pauley | Pedro Strop | Brandon League | 149 | 130 | 19 |
| 2011-05-04 | @ SEA | 31 | W 5-2 | 17-14 | 2 | 13,896 | C.J. Wilson | Michael Pineda | C.J. Wilson | Michael Pineda | | 154 | 132 | 22 |
| 2011-05-05 | @ SEA | 32 | L 1-3 | 17-15 | 2 | 14,205 | Colby Lewis | Jason Vargas | Jason Vargas | Colby Lewis | Brandon League | 155 | 135 | 20 |
| 2011-05-06 | vs NYA | 33 | L 1-4 | 17-16 | 3 | 49,069 | Matt Harrison | Ivan Nova | Ivan Nova | Matt Harrison | Mariano Rivera | 156 | 139 | 17 |
| 2011-05-07 | vs NYA | 34 | W 7-5 | 18-16 | 2 | 49,574 | Derek Holland | Bartolo Colon | Arthur Rhodes | Boone Logan | Neftali Feliz | 163 | 144 | 19 |
| 2011-05-08 | vs NYA | 35 | L 5-12 | 18-17 | 3 | 48,057 | David Bush | CC Sabathia | CC Sabathia | Arthur Rhodes | | 168 | 156 | 12 |
| 2011-05-09 | vs OAK | 36 | L 2-7 | 18-18 | 3 | 24,375 | C.J. Wilson | Trevor Cahill | Trevor Cahill | C.J. Wilson | | 170 | 163 | 7 |
| 2011-05-10 | vs OAK | 37 | W 7-2 | 19-18 | 3 | 31,655 | Colby Lewis | Brett Anderson | Colby Lewis | Brett Anderson | | 177 | 165 | 12 |
| 2011-05-13 | vs ANA | 38 | W 4-1 | 20-18 | 2 | 45,995 | Alexi Ogando | Jered Weaver | Alexi Ogando | Jered Weaver | Neftali Feliz | 181 | 166 | 15 |
| 2011-05-14 | vs ANA | 39 | L 2-3 | 20-19 | 3 | 47,663 | Derek Holland | Dan Haren | Scott Downs | Darren Oliver | Jordan Walden | 183 | 169 | 14 |
| 2011-05-15 | vs ANA | 40 | W 5-4 | 21-19 | 2 | 48,284 | C.J. Wilson | Ervin Santana | Mark Lowe | Rich Thompson | Neftali Feliz | 188 | 173 | 15 |
| 2011-05-16 | @ CHA | 41 | W 4-0 | 22-19 | 1 | 23,048 | Colby Lewis | Edwin Jackson | Colby Lewis | Edwin Jackson | | 192 | 173 | 19 |
| 2011-05-17 | @ CHA | 42 | L 3-4 | 22-20 | 2 | 22,437 | Matt Harrison | John Danks | Jesse Crain | Cody Eppley | Sergio Santos | 195 | 177 | 18 |
| 2011-05-18 | @ KCA | 43 | W 5-4 | 23-20 | 1 | 13,789 | Alexi Ogando | Danny Duffy | Arthur Rhodes | Jeremy Jeffress | Mark Lowe | 200 | 181 | 19 |
| 2011-05-19 | @ KCA | 44 | L 1-2 | 23-21 | 1 | 12,355 | Derek Holland | Luke Hochevar | Greg Holland | Darren Oliver | | 201 | 183 | 18 |
| 2011-05-20 | @ PHI | 45 | L 2-3 | 23-22 | 1 | 45,358 | C.J. Wilson | Roy Halladay | Roy Halladay | C.J. Wilson | Ryan Madson | 203 | 186 | 17 |
| 2011-05-21 | @ PHI | 46 | L 0-2 | 23-23 | 1 | 45,604 | Colby Lewis | Cliff Lee | Cliff Lee | Colby Lewis | Ryan Madson | 203 | 188 | 15 |
| 2011-05-22 | @ PHI | 47 | W 2-0 | 24-23 | 1 | 45,633 | Matt Harrison | Roy Oswalt | Matt Harrison | Roy Oswalt | Neftali Feliz | 205 | 188 | 17 |
| 2011-05-23 | vs CHA | 48 | W 4-0 | 25-23 | 1 | 30,861 | Alexi Ogando | John Danks | Alexi Ogando | John Danks | | 209 | 188 | 21 |
| 2011-05-24 | vs CHA | 49 | L 6-8 | 25-24 | 1 | 35,524 | Derek Holland | Jake Peavy | Tony Pena | Brett Tomko | Sergio Santos | 215 | 196 | 19 |
| 2011-05-25 | vs CHA | 50 | W 2-1 | 26-24 | 1 | 32,382 | C.J. Wilson | Gavin Floyd | C.J. Wilson | Gavin Floyd | Neftali Feliz | 217 | 197 | 20 |
| 2011-05-27 | vs KCA | 51 | L 7-12 | 26-25 | 1 | 39,390 | Colby Lewis | Nathan Adcock | Blake Wood | David Bush | | 224 | 209 | 15 |
| 2011-05-28 | vs KCA | 52 | W 10-1 | 27-25 | 1 | 40,240 | Matt Harrison | Sean O'Sullivan | Matt Harrison | Sean O'Sullivan | Yoshinori Tateyama | 234 | 210 | 24 |
| 2011-05-29 | vs KCA | 53 | W 7-6 | 28-25 | 1 | 45,011 | Alexi Ogando | Danny Duffy | Arthur Rhodes | Joakim Soria | | 241 | 216 | 25 |
| 2011-05-30 | @ TBA | 54 | W 11-5 | 29-25 | 1 | 14,203 | Derek Holland | Wade Davis | Derek Holland | Wade Davis | | 252 | 221 | 31 |
| 2011-05-31 | @ TBA | 55 | L 4-5 | 29-26 | 1 | 12,783 | C.J. Wilson | Alex Cobb | Joel Peralta | Arthur Rhodes | Kyle Farnsworth | 256 | 226 | 30 |
| 2011-06-01 | @ TBA | 56 | W 3-0 | 30-26 | 1 | 13,725 | Colby Lewis | David Price | Colby Lewis | David Price | Neftali Feliz | 259 | 226 | 33 |
| 2011-06-02 | @ CLE | 57 | W 7-4 | 31-26 | 1 | 15,336 | David Bush | Carlos Carrasco | Michael Kirkman | Carlos Carrasco | Neftali Feliz | 266 | 230 | 36 |
| 2011-06-03 | @ CLE | 58 | W 11-2 | 32-26 | 1 | 27,458 | Alexi Ogando | Justin Masterson | Alexi Ogando | Justin Masterson | | 277 | 232 | 45 |
| 2011-06-04 | @ CLE | 59 | W 4-0 | 33-26 | 1 | 30,130 | Derek Holland | Fausto Carmona | Derek Holland | Fausto Carmona | | 281 | 232 | 49 |
| 2011-06-05 | @ CLE | 60 | W 2-0 | 34-26 | 1 | 20,621 | C.J. Wilson | Mitch Talbot | C.J. Wilson | Mitch Talbot | Neftali Feliz | 283 | 232 | 51 |
| 2011-06-06 | vs DET | 61 | L 7-13 | 34-27 | 1 | 33,921 | Colby Lewis | Max Scherzer | Max Scherzer | Colby Lewis | | 290 | 245 | 45 |
| 2011-06-07 | vs DET | 62 | L 1-8 | 34-28 | 1 | 35,165 | Matt Harrison | Rick Porcello | Rick Porcello | Matt Harrison | | 291 | 253 | 38 |
| 2011-06-08 | vs DET | 63 | W 7-3 | 35-28 | 1 | 40,388 | Alexi Ogando | Phil Coke | Alexi Ogando | Phil Coke | | 298 | 256 | 42 |
| 2011-06-09 | @ MIN | 64 | L 4-5 | 35-29 | 1 | 38,761 | Derek Holland | Nick Blackburn | Jim Hoey | Mark Lowe | | 302 | 261 | 41 |
| 2011-06-10 | @ MIN | 65 | W 9-3 | 36-29 | 1 | 38,907 | C.J. Wilson | Brian Duensing | C.J. Wilson | Brian Duensing | | 311 | 264 | 47 |
| 2011-06-11 | @ MIN | 66 | L 1-8 | 36-30 | 1 | 40,420 | Colby Lewis | Scott Baker | Scott Baker | Colby Lewis | | 312 | 272 | 40 |
| 2011-06-12 | @ MIN | 67 | L 1-6 | 36-31 | 1 | 39,281 | Matt Harrison | Francisco Liriano | Francisco Liriano | Matt Harrison | | 313 | 278 | 35 |
| 2011-06-14 | @ NYA | 68 | L 4-12 | 36-32 | 1 | 43,457 | Alexi Ogando | CC Sabathia | CC Sabathia | Alexi Ogando | | 317 | 290 | 27 |
| 2011-06-15 | @ NYA | 69 | L 4-12 | 36-33 | 1 | 45,969 | Derek Holland | Ivan Nova | Ivan Nova | Derek Holland | | 321 | 302 | 19 |
| 2011-06-16 | @ NYA | 70 | L 2-3 | 36-34 | 1 | 47,487 | C.J. Wilson | Brian Gordon | Cory Wade | Michael Kirkman | | 323 | 305 | 18 |
| 2011-06-17 | @ ATL | 71 | W 6-2 | 37-34 | 1 | 38,810 | Colby Lewis | Randall Delgado | Colby Lewis | Randall Delgado | | 329 | 307 | 22 |
| 2011-06-18 | @ ATL | 72 | W 5-4 | 38-34 | 1 | 44,600 | Matt Harrison | Derek Lowe | Mark Lowe | Scott Proctor | Neftali Feliz | 334 | 311 | 23 |
| 2011-06-19 | @ ATL | 73 | L 2-4 | 38-35 | 1 | 34,599 | Alexi Ogando | Jair Jurrjens | Jair Jurrjens | Alexi Ogando | Craig Kimbrel | 336 | 315 | 21 |
| 2011-06-20 | vs HOU | 74 | W 8-3 | 39-35 | 1 | 41,205 | Derek Holland | J.A. Happ | Derek Holland | J.A. Happ | | 344 | 318 | 26 |
| 2011-06-21 | vs HOU | 75 | W 5-4 | 40-35 | 1 | 33,533 | C.J. Wilson | Jordan Lyles | Yoshinori Tateyama | Enerio Del Rosario | | 349 | 322 | 27 |
| 2011-06-22 | vs HOU | 76 | L 3-5 | 40-36 | 1 | 39,708 | Colby Lewis | Brett Myers | Mark Melancon | Neftali Feliz | | 352 | 327 | 25 |
| 2011-06-24 | vs NYN | 77 | W 8-1 | 41-36 | 1 | 46,092 | Matt Harrison | Mike Pelfrey | Matt Harrison | Mike Pelfrey | | 360 | 328 | 32 |
| 2011-06-25 | vs NYN | 78 | L 5-14 | 41-37 | 1 | 37,292 | Alexi Ogando | Jonathon Niese | Jonathon Niese | Alexi Ogando | | 365 | 342 | 23 |
| 2011-06-26 | vs NYN | 79 | L 5-8 | 41-38 | 1 | 37,879 | Derek Holland | Dillon Gee | Dillon Gee | Derek Holland | | 370 | 350 | 20 |
| 2011-06-28 | @ HOU | 80 | W 7-3 | 42-38 | 1 | 29,132 | C.J. Wilson | Jordan Lyles | C.J. Wilson | Jordan Lyles | Neftali Feliz | 377 | 353 | 24 |
| 2011-06-29 | @ HOU | 81 | W 3-2 | 43-38 | 1 | 24,472 | Colby Lewis | Brett Myers | Colby Lewis | Brett Myers | Neftali Feliz | 380 | 355 | 25 |
| 2011-06-30 | @ HOU | 82 | L 0-7 | 43-39 | 1 | 25,938 | Matt Harrison | Wandy Rodriguez | Wandy Rodriguez | Matt Harrison | | 380 | 362 | 18 |
| 2011-07-01 | vs FLO | 83 | W 15-5 | 44-39 | 1 | 32,474 | Alexi Ogando | Anibal Sanchez | Alexi Ogando | Anibal Sanchez | | 395 | 367 | 28 |
| 2011-07-02 | vs FLO | 84 | L 5-9 | 44-40 | 1 | 29,728 | Derek Holland | Brad Hand | Steve Cishek | Derek Holland | | 400 | 376 | 24 |
| 2011-07-03 | vs FLO | 85 | L 4-6 | 44-41 | 2 | 46,092 | C.J. Wilson | Javier Vazquez | Michael Dunn | Mark Lowe | Leo Nunez | 404 | 382 | 22 |
| 2011-07-04 | vs BAL | 86 | W 13-4 | 45-41 | 2 | 42,885 | Colby Lewis | Chris Jakubauskas | Colby Lewis | Chris Jakubauskas | | 417 | 386 | 31 |
| 2011-07-05 | vs BAL | 87 | W 4-2 | 46-41 | 2 | 25,945 | Matt Harrison | Mitch Atkins | Tommy Hunter | Jim Johnson | Neftali Feliz | 421 | 388 | 33 |
| 2011-07-06 | vs BAL | 88 | W 13-5 | 47-41 | 1 | 31,953 | Alexi Ogando | Jeremy Guthrie | Alexi Ogando | Jeremy Guthrie | | 434 | 393 | 41 |
| 2011-07-07 | vs OAK | 89 | W 6-0 | 48-41 | 1 | 35,041 | Derek Holland | Rich Harden | Derek Holland | Rich Harden | | 440 | 393 | 47 |
| 2011-07-08 | vs OAK | 90 | W 8-5 | 49-41 | 1 | 37,858 | C.J. Wilson | Gio Gonzalez | C.J. Wilson | Gio Gonzalez | | 448 | 398 | 50 |
| 2011-07-09 | vs OAK | 91 | W 7-6 | 50-41 | 1 | 34,066 | Colby Lewis | Brandon McCarthy | Darren Oliver | Andrew Bailey | | 455 | 404 | 51 |
| 2011-07-10 | vs OAK | 92 | W 2-0 | 51-41 | 1 | 33,834 | Matt Harrison | Trevor Cahill | Matt Harrison | Trevor Cahill | Neftali Feliz | 457 | 404 | 53 |
| 2011-07-14 | @ SEA | 93 | W 5-0 | 52-41 | 1 | 25,997 | Derek Holland | Jason Vargas | Derek Holland | Jason Vargas | | 462 | 404 | 58 |
| 2011-07-15 | @ SEA | 94 | W 4-0 | 53-41 | 1 | 30,551 | Colby Lewis | Doug Fister | Colby Lewis | Doug Fister | Neftali Feliz | 466 | 404 | 62 |
| 2011-07-16 | @ SEA | 95 | W 5-1 | 54-41 | 1 | 30,896 | C.J. Wilson | Felix Hernandez | C.J. Wilson | Felix Hernandez | | 471 | 405 | 66 |
| 2011-07-17 | @ SEA | 96 | W 3-1 | 55-41 | 1 | 30,335 | Matt Harrison | Blake Beavan | Matt Harrison | Blake Beavan | Neftali Feliz | 474 | 406 | 68 |
| 2011-07-19 | @ ANA | 97 | W 7-0 | 56-41 | 1 | 43,103 | Alexi Ogando | Tyler Chatwood | Alexi Ogando | Tyler Chatwood | | 481 | 406 | 75 |
| 2011-07-20 | @ ANA | 98 | L 8-9 | 56-42 | 1 | 40,052 | Derek Holland | Dan Haren | Hisanori Takahashi | Tommy Hunter | Jordan Walden | 489 | 415 | 74 |
| 2011-07-21 | @ ANA | 99 | L 0-1 | 56-43 | 1 | 38,315 | C.J. Wilson | Jered Weaver | Jered Weaver | C.J. Wilson | Jordan Walden | 489 | 416 | 73 |
| 2011-07-22 | vs TOR | 100 | W 12-2 | 57-43 | 1 | 37,360 | Colby Lewis | Jo-Jo Reyes | Colby Lewis | Jo-Jo Reyes | | 501 | 418 | 83 |
| 2011-07-23 | vs TOR | 101 | W 5-4 | 58-43 | 1 | 38,537 | Matt Harrison | Carlos Villanueva | Darren Oliver | Marc Rzepczynski | | 506 | 422 | 84 |
| 2011-07-24 | vs TOR | 102 | L 0-3 | 58-44 | 1 | 43,117 | Alexi Ogando | Brett Cecil | Brett Cecil | Alexi Ogando | | 506 | 425 | 81 |
| 2011-07-25 | vs MIN | 103 | W 20-6 | 59-44 | 1 | 35,573 | Derek Holland | Nick Blackburn | Derek Holland | Nick Blackburn | | 526 | 431 | 95 |
| 2011-07-26 | vs MIN | 104 | L 8-9 | 59-45 | 1 | 30,581 | C.J. Wilson | Carl Pavano | Glen Perkins | Neftali Feliz | Joe Nathan | 534 | 440 | 94 |
| 2011-07-27 | vs MIN | 105 | L 2-7 | 59-46 | 1 | 35,950 | Colby Lewis | Brian Duensing | Brian Duensing | Colby Lewis | | 536 | 447 | 89 |
| 2011-07-28 | vs MIN | 106 | W 4-1 | 60-46 | 1 | 30,406 | Matt Harrison | Scott Baker | Matt Harrison | Scott Baker | Neftali Feliz | 540 | 448 | 92 |
| 2011-07-29 | @ TOR | 107 | L 2-3 | 60-47 | 1 | 19,287 | Alexi Ogando | Brett Cecil | Brett Cecil | Alexi Ogando | Jon Rauch | 542 | 451 | 91 |
| 2011-07-30 | @ TOR | 108 | W 3-0 | 61-47 | 1 | 22,560 | Derek Holland | Brad Mills | Derek Holland | Brad Mills | | 545 | 451 | 94 |
| 2011-07-31 | @ TOR | 109 | L 3-7 | 61-48 | 1 | 45,629 | C.J. Wilson | Brandon Morrow | Brandon Morrow | C.J. Wilson | | 548 | 458 | 90 |
| 2011-08-02 | @ DET | 110 | L 5-6 | 61-49 | 1 | 29,067 | Colby Lewis | Max Scherzer | Joaquin Benoit | Mike Adams | Jose Valverde | 553 | 464 | 89 |
| 2011-08-03 | @ DET | 111 | L 4-5 | 61-50 | 1 | 33,596 | Matt Harrison | Doug Fister | Doug Fister | Matt Harrison | Jose Valverde | 557 | 469 | 88 |
| 2011-08-04 | @ DET | 112 | W 5-2 | 62-50 | 1 | 40,497 | Alexi Ogando | Brad Penny | Alexi Ogando | Brad Penny | Neftali Feliz | 562 | 471 | 91 |
| 2011-08-05 | vs CLE | 113 | W 8-7 | 63-50 | 1 | 37,842 | Derek Holland | Ubaldo Jimenez | Neftali Feliz | Rafael Perez | | 570 | 478 | 92 |
| 2011-08-06 | vs CLE | 114 | L 5-7 | 63-51 | 1 | 38,210 | C.J. Wilson | Fausto Carmona | Frank Herrmann | Neftali Feliz | Chris Perez | 575 | 485 | 90 |
| 2011-08-07 | vs CLE | 115 | W 5-3 | 64-51 | 1 | 37,431 | Colby Lewis | Josh Tomlin | Darren Oliver | Joe Smith | Mike Adams | 580 | 488 | 92 |
| 2011-08-08 | vs SEA | 116 | W 9-2 | 65-51 | 1 | 27,771 | Matt Harrison | Charlie Furbush | Matt Harrison | Charlie Furbush | | 589 | 490 | 99 |
| 2011-08-09 | vs SEA | 117 | W 7-6 | 66-51 | 1 | 25,214 | Alexi Ogando | Michael Pineda | Neftali Feliz | Jeff Gray | | 596 | 496 | 100 |
| 2011-08-10 | vs SEA | 118 | L 3-4 | 66-52 | 1 | 30,087 | Derek Holland | Jason Vargas | Jason Vargas | Koji Uehara | Brandon League | 599 | 500 | 99 |
| 2011-08-12 | @ OAK | 119 | W 9-1 | 67-52 | 1 | 20,288 | C.J. Wilson | Brandon McCarthy | C.J. Wilson | Brandon McCarthy | | 608 | 501 | 107 |
| 2011-08-13 | @ OAK | 120 | W 7-1 | 68-52 | 1 | 25,160 | Colby Lewis | Trevor Cahill | Colby Lewis | Trevor Cahill | | 615 | 502 | 113 |
| 2011-08-14 | @ OAK | 121 | W 7-6 | 69-52 | 1 | 15,107 | Matt Harrison | Rich Harden | Mike Adams | Andrew Bailey | Neftali Feliz | 622 | 508 | 114 |
| 2011-08-15 | @ ANA | 122 | W 8-4 | 70-52 | 1 | 36,663 | Alexi Ogando | Garrett Richards | Alexi Ogando | Bobby Cassevah | | 630 | 512 | 118 |
| 2011-08-16 | @ ANA | 123 | W 7-3 | 71-52 | 1 | 43,711 | Derek Holland | Tyler Chatwood | Derek Holland | Tyler Chatwood | | 637 | 515 | 122 |
| 2011-08-17 | @ ANA | 124 | W 4-3 | 72-52 | 1 | 36,581 | C.J. Wilson | Ervin Santana | C.J. Wilson | Ervin Santana | Neftali Feliz | 641 | 518 | 123 |
| 2011-08-18 | @ ANA | 125 | L 1-2 | 72-53 | 1 | 41,123 | Colby Lewis | Jered Weaver | Horacio Ramirez | Mike Adams | | 642 | 520 | 122 |
| 2011-08-19 | @ CHA | 126 | W 7-4 | 73-53 | 1 | 28,308 | Matt Harrison | Jake Peavy | Yoshinori Tateyama | Jake Peavy | Neftali Feliz | 649 | 524 | 125 |
| 2011-08-20 | @ CHA | 127 | L 2-3 | 73-54 | 1 | 30,021 | Alexi Ogando | John Danks | Jesse Crain | Koji Uehara | Sergio Santos | 651 | 527 | 124 |
| 2011-08-21 | @ CHA | 128 | L 0-10 | 73-55 | 1 | 25,033 | Derek Holland | Gavin Floyd | Gavin Floyd | Derek Holland | | 651 | 537 | 114 |
| 2011-08-22 | vs BOS | 129 | W 4-0 | 74-55 | 1 | 33,920 | C.J. Wilson | Erik Bedard | C.J. Wilson | Erik Bedard | | 655 | 537 | 118 |
| 2011-08-23 | vs BOS | 130 | L 5-11 | 74-56 | 1 | 25,705 | Colby Lewis | John Lackey | John Lackey | Colby Lewis | | 660 | 548 | 112 |
| 2011-08-24 | vs BOS | 131 | L 2-13 | 74-57 | 1 | 30,724 | Matt Harrison | Josh Beckett | Josh Beckett | Matt Harrison | | 662 | 561 | 101 |
| 2011-08-25 | vs BOS | 132 | L 0-6 | 74-58 | 1 | 29,729 | Alexi Ogando | Andrew Miller | Andrew Miller | Alexi Ogando | | 662 | 567 | 95 |
| 2011-08-26 | vs ANA | 133 | W 11-7 | 75-58 | 1 | 38,256 | Derek Holland | Dan Haren | Derek Holland | Dan Haren | | 673 | 574 | 99 |
| 2011-08-27 | vs ANA | 134 | L 4-8 | 75-59 | 1 | 48,453 | C.J. Wilson | Ervin Santana | Ervin Santana | C.J. Wilson | Hisanori Takahashi | 677 | 582 | 95 |
| 2011-08-28 | vs ANA | 135 | W 9-5 | 76-59 | 1 | 40,018 | Colby Lewis | Jered Weaver | Darren Oliver | Jered Weaver | | 686 | 587 | 99 |
| 2011-08-30 | vs TBA | 136 | W 2-0 | 77-59 | 1 | 23,069 | Scott Feldman | Jeremy Hellickson | Scott Feldman | Jeremy Hellickson | Neftali Feliz | 688 | 587 | 101 |
| 2011-08-31 | vs TBA | 137 | L 1-4 | 77-60 | 1 | 28,034 | Alexi Ogando | James Shields | James Shields | Alexi Ogando | | 689 | 591 | 98 |
| 2011-09-01 | vs TBA | 138 | W 7-2 | 78-60 | 1 | 26,220 | C.J. Wilson | Jeff Niemann | C.J. Wilson | Jeff Niemann | | 696 | 593 | 103 |
| 2011-09-02 | @ BOS | 139 | W 10-0 | 79-60 | 1 | 38,083 | Derek Holland | Andrew Miller | Derek Holland | Andrew Miller | | 706 | 593 | 113 |
| 2011-09-03 | @ BOS | 140 | L 7-12 | 79-61 | 1 | 37,806 | Colby Lewis | Erik Bedard | Erik Bedard | Colby Lewis | | 713 | 605 | 108 |
| 2011-09-04 | @ BOS | 141 | W 11-4 | 80-61 | 1 | 37,744 | Matt Harrison | John Lackey | Matt Harrison | John Lackey | | 724 | 609 | 115 |
| 2011-09-05 | @ TBA | 142 | L 1-5 | 80-62 | 1 | 13,130 | Scott Feldman | James Shields | James Shields | Scott Feldman | | 725 | 614 | 111 |
| 2011-09-06 | @ TBA | 143 | W 8-0 | 81-62 | 1 | 11,611 | C.J. Wilson | Jeff Niemann | C.J. Wilson | Jeff Niemann | | 733 | 614 | 119 |
| 2011-09-07 | @ TBA | 144 | L 4-5 | 81-63 | 1 | 11,190 | Derek Holland | David Price | Jake McGee | Mark Lowe | | 737 | 619 | 118 |
| 2011-09-09 | vs OAK | 145 | W 13-4 | 82-63 | 1 | 36,706 | Colby Lewis | Brandon McCarthy | Colby Lewis | Brandon McCarthy | | 750 | 623 | 127 |
| 2011-09-10 | vs OAK | 146 | L 7-8 | 82-64 | 1 | 46,151 | Alexi Ogando | Trevor Cahill | Trevor Cahill | Alexi Ogando | Andrew Bailey | 757 | 631 | 126 |
| 2011-09-11 | vs OAK | 147 | W 8-1 | 83-64 | 1 | 46,727 | C.J. Wilson | Josh Outman | C.J. Wilson | Josh Outman | | 765 | 632 | 133 |
| 2011-09-13 | vs CLE | 148 | W 10-4 | 84-64 | 1 | 30,107 | Matt Harrison | Justin Masterson | Matt Harrison | Justin Masterson | | 775 | 636 | 139 |
| 2011-09-14 | vs CLE | 149 | W 9-1 | 85-64 | 1 | 38,710 | Derek Holland | David Huff | Derek Holland | David Huff | | 784 | 637 | 147 |
| 2011-09-15 | vs CLE | 150 | W 7-4 | 86-64 | 1 | 44,242 | Alexi Ogando | Fausto Carmona | Alexi Ogando | Fausto Carmona | | 791 | 641 | 150 |
| 2011-09-16 | @ SEA | 151 | L 0-4 | 86-65 | 1 | 17,607 | C.J. Wilson | Blake Beavan | Blake Beavan | C.J. Wilson | | 791 | 645 | 146 |
| 2011-09-17 | @ SEA | 152 | W 7-6 | 87-65 | 1 | 22,159 | Colby Lewis | Anthony Vasquez | Colby Lewis | Anthony Vasquez | Neftali Feliz | 798 | 651 | 147 |
| 2011-09-18 | @ SEA | 153 | W 3-0 | 88-65 | 1 | 21,479 | Matt Harrison | Felix Hernandez | Matt Harrison | Felix Hernandez | Neftali Feliz | 801 | 651 | 150 |
| 2011-09-20 | @ OAK | 154 | W 7-2 | 89-65 | 1 | 13,635 | Derek Holland | Rich Harden | Derek Holland | Rich Harden | | 808 | 653 | 155 |
| 2011-09-21 | @ OAK | 155 | W 3-2 | 90-65 | 1 | 19,589 | C.J. Wilson | Brandon McCarthy | Koji Uehara | Grant Balfour | Neftali Feliz | 811 | 655 | 156 |
| 2011-09-22 | @ OAK | 156 | L 3-4 | 90-66 | 1 | 14,090 | Colby Lewis | Trevor Cahill | Grant Balfour | Mike Adams | Andrew Bailey | 814 | 659 | 155 |
| 2011-09-23 | vs SEA | 157 | W 5-3 | 91-66 | 1 | 43,874 | Matt Harrison | Anthony Vasquez | Matt Harrison | Anthony Vasquez | Neftali Feliz | 819 | 662 | 157 |
| 2011-09-24 | vs SEA | 158 | W 7-3 | 92-66 | 1 | 40,242 | Alexi Ogando | Felix Hernandez | Scott Feldman | Felix Hernandez | | 826 | 665 | 161 |
| 2011-09-25 | vs SEA | 159 | W 12-5 | 93-66 | 1 | 43,508 | Derek Holland | Charlie Furbush | Derek Holland | Charlie Furbush | | 838 | 670 | 168 |
| 2011-09-26 | @ ANA | 160 | W 4-3 | 94-66 | 1 | 39,716 | C.J. Wilson | Dan Haren | Mark Hamburger | Dan Haren | Neftali Feliz | 842 | 673 | 169 |
| 2011-09-27 | @ ANA | 161 | W 10-3 | 95-66 | 1 | 39,529 | Colby Lewis | Tyler Chatwood | Colby Lewis | Tyler Chatwood | | 852 | 676 | 176 |
| 2011-09-28 | @ ANA | 162 | W 3-1 | 96-66 | 1 | 39,612 | Matt Harrison | Garrett Richards | Mike Adams | Jordan Walden | Neftali Feliz | 855 | 677 | 178 |