| 2011-04-01 | vs BAL | 1 | L 1-4 | 0-1 | 5 | 34,078 | David Price | Jeremy Guthrie | Jeremy Guthrie | David Price | | 1 | 4 | -3 |
| 2011-04-02 | vs BAL | 2 | L 1-3 | 0-2 | 5 | 22,164 | James Shields | Chris Tillman | Jeremy Accardo | James Shields | Kevin Gregg | 2 | 7 | -5 |
| 2011-04-03 | vs BAL | 3 | L 1-5 | 0-3 | 5 | 17,408 | Wade Davis | Zachary Britton | Zachary Britton | Wade Davis | | 3 | 12 | -9 |
| 2011-04-05 | vs ANA | 4 | L 3-5 | 0-4 | 5 | 13,173 | Jeff Niemann | Jered Weaver | Jered Weaver | Jeff Niemann | Jordan Walden | 6 | 17 | -11 |
| 2011-04-06 | vs ANA | 5 | L 1-5 | 0-5 | 5 | 11,836 | Jeremy Hellickson | Dan Haren | Dan Haren | Jeremy Hellickson | | 7 | 22 | -15 |
| 2011-04-07 | @ CHA | 6 | L 1-5 | 0-6 | 5 | 38,579 | David Price | Edwin Jackson | Edwin Jackson | David Price | | 8 | 27 | -19 |
| 2011-04-08 | @ CHA | 7 | W 9-7 | 1-6 | 5 | 20,199 | James Shields | John Danks | Adam Russell | Matt Thornton | Kyle Farnsworth | 17 | 34 | -17 |
| 2011-04-09 | @ CHA | 8 | L 2-4 | 1-7 | 6 | 26,378 | Wade Davis | Philip Humber | Philip Humber | Wade Davis | Chris Sale | 19 | 38 | -19 |
| 2011-04-10 | @ CHA | 9 | L 1-6 | 1-8 | 5 | 23,436 | Jeff Niemann | Gavin Floyd | Gavin Floyd | Jeff Niemann | | 20 | 44 | -24 |
| 2011-04-11 | @ BOS | 10 | W 16-5 | 2-8 | 5 | 37,568 | Jeremy Hellickson | Daisuke Matsuzaka | Jeremy Hellickson | Daisuke Matsuzaka | | 36 | 49 | -13 |
| 2011-04-12 | @ BOS | 11 | W 3-2 | 3-8 | 4 | 37,015 | David Price | Jon Lester | David Price | Jon Lester | Kyle Farnsworth | 39 | 51 | -12 |
| 2011-04-14 | vs MIN | 12 | W 4-3 | 4-8 | 4 | 10,042 | James Shields | Carl Pavano | Kyle Farnsworth | Matt Capps | | 43 | 54 | -11 |
| 2011-04-15 | vs MIN | 13 | W 5-2 | 5-8 | 4 | 15,342 | Wade Davis | Nick Blackburn | Wade Davis | Nick Blackburn | Kyle Farnsworth | 48 | 56 | -8 |
| 2011-04-16 | vs MIN | 14 | W 4-3 | 6-8 | 4 | 16,428 | Jeff Niemann | Scott Baker | Juan Cruz | Joe Nathan | | 52 | 59 | -7 |
| 2011-04-17 | vs MIN | 15 | L 2-4 | 6-9 | 4 | 22,426 | Jeremy Hellickson | Brian Duensing | Brian Duensing | Jeremy Hellickson | Matt Capps | 54 | 63 | -9 |
| 2011-04-18 | vs CHA | 16 | W 5-0 | 7-9 | 2 | 12,016 | David Price | Edwin Jackson | David Price | Edwin Jackson | | 59 | 63 | -4 |
| 2011-04-19 | vs CHA | 17 | W 2-1 | 8-9 | 2 | 13,731 | James Shields | John Danks | James Shields | John Danks | | 61 | 64 | -3 |
| 2011-04-20 | vs CHA | 18 | W 4-1 | 9-9 | 2 | 13,214 | Wade Davis | Philip Humber | Wade Davis | Philip Humber | Kyle Farnsworth | 65 | 65 | 0 |
| 2011-04-21 | vs CHA | 19 | L 2-9 | 9-10 | 2 | 16,751 | Jeff Niemann | Gavin Floyd | Gavin Floyd | Jeff Niemann | | 67 | 74 | -7 |
| 2011-04-22 | @ TOR | 20 | L 4-6 | 9-11 | 3 | 23,192 | Jeremy Hellickson | Jo-Jo Reyes | Marc Rzepczynski | Adam Russell | | 71 | 80 | -9 |
| 2011-04-23 | @ TOR | 21 | W 6-4 | 10-11 | 2 | 21,826 | David Price | Brandon Morrow | David Price | Brandon Morrow | Kyle Farnsworth | 77 | 84 | -7 |
| 2011-04-24 | @ TOR | 22 | W 2-0 | 11-11 | 2 | 14,456 | James Shields | Ricky Romero | James Shields | Ricky Romero | | 79 | 84 | -5 |
| 2011-04-27 | @ MIN | 23 | W 8-2 | 12-11 | 2 | 36,714 | Wade Davis | Francisco Liriano | Wade Davis | Francisco Liriano | | 87 | 86 | 1 |
| 2011-04-28 | @ MIN | 24 | W 15-3 | 13-11 | 3 | 38,215 | Jeremy Hellickson | Nick Blackburn | Jeremy Hellickson | Nick Blackburn | | 102 | 89 | 13 |
| 2011-04-28 | @ MIN | 25 | W 6-1 | 13-11 | 3 | 36,456 | Jeff Niemann | Anthony Swarzak | Jeff Niemann | Anthony Swarzak | | 108 | 90 | 18 |
| 2011-04-29 | vs ANA | 26 | L 5-8 | 14-12 | 2 | 21,791 | David Price | Ervin Santana | Ervin Santana | David Price | Jordan Walden | 113 | 98 | 15 |
| 2011-04-30 | vs ANA | 27 | W 2-1 | 15-12 | 2 | 20,245 | James Shields | Joel Pineiro | Joel Peralta | Fernando Rodney | | 115 | 99 | 16 |
| 2011-05-01 | vs ANA | 28 | L 5-6 | 15-13 | 2 | 16,248 | Alex Cobb | Tyler Chatwood | Rich Thompson | Joel Peralta | Jordan Walden | 120 | 105 | 15 |
| 2011-05-03 | vs TOR | 29 | W 3-2 | 16-13 | 2 | 10,248 | Wade Davis | Jo-Jo Reyes | Kyle Farnsworth | Jon Rauch | | 123 | 107 | 16 |
| 2011-05-04 | vs TOR | 30 | L 2-3 | 16-14 | 2 | 10,099 | Jeff Niemann | Brandon Morrow | Brandon Morrow | Jeff Niemann | Frank Francisco | 125 | 110 | 15 |
| 2011-05-05 | vs TOR | 31 | W 3-1 | 17-14 | 2 | 12,682 | David Price | Kyle Drabek | David Price | Kyle Drabek | Kyle Farnsworth | 128 | 111 | 17 |
| 2011-05-06 | @ BAL | 32 | W 6-2 | 18-14 | 2 | 20,694 | James Shields | Zachary Britton | James Shields | Zachary Britton | | 134 | 113 | 21 |
| 2011-05-07 | @ BAL | 33 | W 8-2 | 19-14 | 2 | 18,961 | Jeremy Hellickson | Jeremy Guthrie | Jeremy Hellickson | Jeremy Guthrie | | 142 | 115 | 27 |
| 2011-05-08 | @ BAL | 34 | W 5-3 | 20-14 | 2 | 16,359 | Wade Davis | Brad Bergesen | Wade Davis | Brad Bergesen | Kyle Farnsworth | 147 | 118 | 29 |
| 2011-05-10 | @ CLE | 35 | L 4-5 | 20-15 | 2 | 13,551 | Andy Sonnanstine | Josh Tomlin | Chris Perez | Joel Peralta | | 151 | 123 | 28 |
| 2011-05-11 | @ CLE | 36 | W 8-2 | 21-15 | 2 | 16,336 | David Price | Carlos Carrasco | David Price | Carlos Carrasco | | 159 | 125 | 34 |
| 2011-05-12 | @ CLE | 37 | W 7-4 | 22-15 | 1 | 18,107 | James Shields | Justin Masterson | James Shields | Justin Masterson | | 166 | 129 | 37 |
| 2011-05-13 | vs BAL | 38 | W 3-0 | 23-15 | 1 | 20,476 | Jeremy Hellickson | Jeremy Guthrie | Jeremy Hellickson | Jeremy Guthrie | | 169 | 129 | 40 |
| 2011-05-14 | vs BAL | 39 | L 0-6 | 23-16 | 1 | 28,451 | Wade Davis | Brad Bergesen | Brad Bergesen | Wade Davis | | 169 | 135 | 34 |
| 2011-05-15 | vs BAL | 40 | L 3-9 | 23-17 | 1 | 21,505 | Andy Sonnanstine | Jake Arrieta | Jake Arrieta | Andy Sonnanstine | | 172 | 144 | 28 |
| 2011-05-16 | vs NYA | 41 | W 6-5 | 24-17 | 1 | 25,024 | David Price | A.J. Burnett | Juan Cruz | A.J. Burnett | Kyle Farnsworth | 178 | 149 | 29 |
| 2011-05-17 | vs NYA | 42 | L 2-6 | 24-18 | 1 | 27,123 | James Shields | Ivan Nova | Ivan Nova | James Shields | | 180 | 155 | 25 |
| 2011-05-18 | @ TOR | 43 | W 6-5 | 25-18 | 1 | 14,415 | Jeremy Hellickson | Jesse Litsch | Jeremy Hellickson | Jesse Litsch | Kyle Farnsworth | 186 | 160 | 26 |
| 2011-05-19 | @ TOR | 44 | L 2-3 | 25-19 | 1 | 12,590 | Wade Davis | Ricky Romero | Ricky Romero | Wade Davis | Frank Francisco | 188 | 163 | 25 |
| 2011-05-20 | @ FLO | 45 | L 3-5 | 25-20 | 1 | 18,111 | Andy Sonnanstine | Anibal Sanchez | Michael Dunn | Joel Peralta | Leo Nunez | 191 | 168 | 23 |
| 2011-05-21 | @ FLO | 46 | L 3-5 | 25-21 | 2 | 21,814 | David Price | Javier Vazquez | Javier Vazquez | David Price | Leo Nunez | 194 | 173 | 21 |
| 2011-05-22 | @ FLO | 47 | W 4-0 | 26-21 | 2 | 15,432 | James Shields | Jay Buente | James Shields | Jay Buente | | 198 | 173 | 25 |
| 2011-05-23 | @ DET | 48 | L 3-6 | 26-22 | 2 | 21,550 | Jeremy Hellickson | Phil Coke | Charlie Furbush | Jeremy Hellickson | | 201 | 179 | 22 |
| 2011-05-24 | @ DET | 49 | L 6-7 | 26-23 | 3 | 24,133 | Wade Davis | Justin Verlander | Al Alburquerque | Cesar Ramos | Joaquin Benoit | 207 | 186 | 21 |
| 2011-05-27 | vs CLE | 50 | W 5-0 | 27-23 | 3 | 16,800 | David Price | Josh Tomlin | David Price | Josh Tomlin | | 212 | 186 | 26 |
| 2011-05-28 | vs CLE | 51 | L 3-7 | 27-24 | 3 | 24,717 | James Shields | Carlos Carrasco | Carlos Carrasco | James Shields | Chris Perez | 215 | 193 | 22 |
| 2011-05-29 | vs CLE | 52 | W 7-0 | 28-24 | 4 | 23,898 | Jeremy Hellickson | Justin Masterson | Jeremy Hellickson | Justin Masterson | | 222 | 193 | 29 |
| 2011-05-30 | vs TEX | 53 | L 5-11 | 28-25 | 3 | 14,203 | Wade Davis | Derek Holland | Derek Holland | Wade Davis | | 227 | 204 | 23 |
| 2011-05-31 | vs TEX | 54 | W 5-4 | 29-25 | 3 | 12,783 | Alex Cobb | C.J. Wilson | Joel Peralta | Arthur Rhodes | Kyle Farnsworth | 232 | 208 | 24 |
| 2011-06-01 | vs TEX | 55 | L 0-3 | 29-26 | 3 | 13,725 | David Price | Colby Lewis | Colby Lewis | David Price | Neftali Feliz | 232 | 211 | 21 |
| 2011-06-02 | @ SEA | 56 | L 2-8 | 29-27 | 3 | 16,376 | James Shields | Felix Hernandez | Felix Hernandez | James Shields | | 234 | 219 | 15 |
| 2011-06-03 | @ SEA | 57 | L 0-7 | 29-28 | 3 | 24,492 | Andy Sonnanstine | Jason Vargas | Jason Vargas | Andy Sonnanstine | | 234 | 226 | 8 |
| 2011-06-04 | @ SEA | 58 | W 3-2 | 30-28 | 3 | 28,843 | Jeremy Hellickson | Doug Fister | Jeremy Hellickson | Doug Fister | Kyle Farnsworth | 237 | 228 | 9 |
| 2011-06-05 | @ SEA | 59 | L 6-9 | 30-29 | 3 | 28,947 | Wade Davis | Erik Bedard | Jamey Wright | J.P. Howell | Brandon League | 243 | 237 | 6 |
| 2011-06-06 | @ ANA | 60 | W 5-1 | 31-29 | 3 | 32,287 | David Price | Tyler Chatwood | David Price | Tyler Chatwood | | 248 | 238 | 10 |
| 2011-06-07 | @ ANA | 61 | W 4-1 | 32-29 | 3 | 38,833 | Alex Cobb | Dan Haren | Alex Cobb | Dan Haren | Kyle Farnsworth | 252 | 239 | 13 |
| 2011-06-08 | @ ANA | 62 | W 4-3 | 33-29 | 3 | 33,157 | James Shields | Jered Weaver | Juan Cruz | Fernando Rodney | Kyle Farnsworth | 256 | 242 | 14 |
| 2011-06-10 | @ BAL | 63 | L 0-7 | 33-30 | 3 | 17,900 | Jeremy Hellickson | Jake Arrieta | Jake Arrieta | Jeremy Hellickson | | 256 | 249 | 7 |
| 2011-06-11 | @ BAL | 64 | W 7-5 | 34-30 | 3 | 25,541 | David Price | Jeremy Guthrie | Juan Cruz | Jeremy Accardo | Kyle Farnsworth | 263 | 254 | 9 |
| 2011-06-12 | @ BAL | 65 | W 9-6 | 35-30 | 3 | 22,032 | Wade Davis | Brian Matusz | Wade Davis | Brian Matusz | J.P. Howell | 272 | 260 | 12 |
| 2011-06-13 | @ DET | 66 | L 1-2 | 35-31 | 3 | 30,938 | Alex Cobb | Phil Coke | David Purcey | Kyle Farnsworth | | 273 | 262 | 11 |
| 2011-06-14 | vs BOS | 67 | W 4-0 | 36-31 | 3 | 20,972 | James Shields | Tim Wakefield | James Shields | Tim Wakefield | | 277 | 262 | 15 |
| 2011-06-15 | vs BOS | 68 | L 0-3 | 36-32 | 3 | 19,388 | Jeremy Hellickson | Josh Beckett | Josh Beckett | Jeremy Hellickson | | 277 | 265 | 12 |
| 2011-06-16 | vs BOS | 69 | L 2-4 | 36-33 | 3 | 23,495 | David Price | Clay Buchholz | Clay Buchholz | David Price | Jonathan Papelbon | 279 | 269 | 10 |
| 2011-06-17 | vs FLO | 70 | W 5-1 | 37-33 | 3 | 15,708 | Wade Davis | Brad Hand | Wade Davis | Brad Hand | Kyle Farnsworth | 284 | 270 | 14 |
| 2011-06-18 | vs FLO | 71 | W 7-4 | 38-33 | 3 | 20,495 | Alex Cobb | Ricky Nolasco | Alex Cobb | Ricky Nolasco | | 291 | 274 | 17 |
| 2011-06-19 | vs FLO | 72 | W 2-1 | 39-33 | 3 | 26,761 | James Shields | Chris Volstad | James Shields | Ryan Webb | | 293 | 275 | 18 |
| 2011-06-20 | @ MIL | 73 | W 8-4 | 40-33 | 3 | 35,495 | Jeff Niemann | Chris Narveson | Jeff Niemann | Chris Narveson | | 301 | 279 | 22 |
| 2011-06-21 | @ MIL | 74 | L 1-5 | 40-34 | 3 | 40,079 | Jeremy Hellickson | Zack Greinke | Zack Greinke | Jeremy Hellickson | | 302 | 284 | 18 |
| 2011-06-22 | @ MIL | 75 | W 6-3 | 41-34 | 4 | 39,632 | David Price | Shaun Marcum | David Price | Marco Estrada | | 308 | 287 | 21 |
| 2011-06-24 | @ HOU | 76 | W 5-1 | 42-34 | 3 | 26,682 | James Shields | Wandy Rodriguez | James Shields | Wandy Rodriguez | | 313 | 288 | 25 |
| 2011-06-25 | @ HOU | 77 | W 7-2 | 43-34 | 3 | 27,208 | Wade Davis | Bud Norris | Wade Davis | Bud Norris | Kyle Farnsworth | 320 | 290 | 30 |
| 2011-06-26 | @ HOU | 78 | W 14-10 | 44-34 | 3 | 23,965 | Jeff Niemann | J.A. Happ | J.P. Howell | Wilton Lopez | | 334 | 300 | 34 |
| 2011-06-27 | vs CIN | 79 | L 0-5 | 44-35 | 3 | 19,891 | Jeremy Hellickson | Mike Leake | Mike Leake | Jeremy Hellickson | | 334 | 305 | 29 |
| 2011-06-28 | vs CIN | 80 | W 4-3 | 45-35 | 3 | 20,894 | David Price | Johnny Cueto | Kyle Farnsworth | Logan Ondrusek | | 338 | 308 | 30 |
| 2011-06-29 | vs CIN | 81 | L 3-4 | 45-36 | 3 | 25,968 | James Shields | Edinson Volquez | Edinson Volquez | James Shields | Francisco Cordero | 341 | 312 | 29 |
| 2011-07-01 | vs SLN | 82 | L 3-5 | 45-37 | 3 | 19,934 | Wade Davis | Jake Westbrook | Jake Westbrook | Wade Davis | Fernando Salas | 344 | 317 | 27 |
| 2011-07-02 | vs SLN | 83 | W 5-1 | 46-37 | 3 | 23,897 | Jeff Niemann | Kyle McClellan | Jeff Niemann | Kyle McClellan | | 349 | 318 | 31 |
| 2011-07-03 | vs SLN | 84 | W 8-3 | 47-37 | 3 | 26,819 | Jeremy Hellickson | Kyle Lohse | Jeremy Hellickson | Kyle Lohse | Kyle Farnsworth | 357 | 321 | 36 |
| 2011-07-04 | @ MIN | 85 | L 0-7 | 47-38 | 3 | 39,528 | David Price | Brian Duensing | Brian Duensing | David Price | | 357 | 328 | 29 |
| 2011-07-05 | @ MIN | 86 | L 2-3 | 47-39 | 3 | 38,613 | James Shields | Scott Baker | Scott Baker | James Shields | Glen Perkins | 359 | 331 | 28 |
| 2011-07-06 | @ MIN | 87 | W 12-5 | 48-39 | 3 | 39,841 | Wade Davis | Francisco Liriano | J.P. Howell | Alex Burnett | | 371 | 336 | 35 |
| 2011-07-07 | @ NYA | 88 | W 5-1 | 49-39 | 3 | 47,787 | Jeff Niemann | Bartolo Colon | Jeff Niemann | Bartolo Colon | | 376 | 337 | 39 |
| 2011-07-09 | @ NYA | 89 | L 4-5 | 49-40 | 3 | 48,103 | David Price | A.J. Burnett | David Robertson | Joel Peralta | Mariano Rivera | 380 | 342 | 38 |
| 2011-07-10 | @ NYA | 90 | L 0-1 | 49-41 | 3 | 47,350 | James Shields | CC Sabathia | CC Sabathia | James Shields | | 380 | 343 | 37 |
| 2011-07-15 | vs BOS | 91 | W 9-6 | 50-41 | 3 | 25,729 | David Price | Andrew Miller | David Price | Andrew Miller | Kyle Farnsworth | 389 | 349 | 40 |
| 2011-07-16 | vs BOS | 92 | L 5-9 | 50-42 | 3 | 32,487 | James Shields | John Lackey | John Lackey | James Shields | | 394 | 358 | 36 |
| 2011-07-17 | vs BOS | 93 | L 0-1 | 50-43 | 3 | 21,504 | Jeff Niemann | Josh Beckett | Alfredo Aceves | Adam Russell | Jonathan Papelbon | 394 | 359 | 35 |
| 2011-07-18 | vs NYA | 94 | L 4-5 | 50-44 | 3 | 22,471 | Alex Cobb | A.J. Burnett | David Robertson | Alexander Torres | Mariano Rivera | 398 | 364 | 34 |
| 2011-07-19 | vs NYA | 95 | W 3-2 | 51-44 | 3 | 22,780 | Jeremy Hellickson | Bartolo Colon | Jeremy Hellickson | Bartolo Colon | Joel Peralta | 401 | 366 | 35 |
| 2011-07-20 | vs NYA | 96 | L 0-4 | 51-45 | 3 | 21,505 | David Price | Freddy Garcia | Freddy Garcia | David Price | | 401 | 370 | 31 |
| 2011-07-21 | vs NYA | 97 | W 2-1 | 52-45 | 3 | 29,279 | James Shields | CC Sabathia | James Shields | CC Sabathia | Kyle Farnsworth | 403 | 371 | 32 |
| 2011-07-22 | @ KCA | 98 | L 4-10 | 52-46 | 3 | 27,824 | Wade Davis | Luke Hochevar | Luke Hochevar | Wade Davis | | 407 | 381 | 26 |
| 2011-07-23 | @ KCA | 99 | L 4-5 | 52-47 | 3 | 27,643 | Jeff Niemann | Jeff Francis | Joakim Soria | Brandon Gomes | | 411 | 386 | 25 |
| 2011-07-24 | @ KCA | 100 | W 5-0 | 53-47 | 3 | 23,735 | Alex Cobb | Felipe Paulino | Alex Cobb | Felipe Paulino | | 416 | 386 | 30 |
| 2011-07-25 | @ OAK | 101 | L 5-7 | 53-48 | 3 | 11,053 | Jeremy Hellickson | Guillermo Moscoso | Brian Fuentes | J.P. Howell | Andrew Bailey | 421 | 393 | 28 |
| 2011-07-26 | @ OAK | 102 | L 1-6 | 53-49 | 3 | 12,166 | David Price | Brandon McCarthy | Brandon McCarthy | David Price | | 422 | 399 | 23 |
| 2011-07-27 | @ OAK | 103 | L 4-13 | 53-50 | 3 | 18,640 | James Shields | Trevor Cahill | Trevor Cahill | James Shields | | 426 | 412 | 14 |
| 2011-07-28 | @ OAK | 104 | W 10-8 | 54-50 | 3 | 16,466 | Wade Davis | Rich Harden | Wade Davis | Brad Ziegler | Kyle Farnsworth | 436 | 420 | 16 |
| 2011-07-29 | @ SEA | 105 | W 8-0 | 55-50 | 3 | 26,570 | Jeff Niemann | Erik Bedard | Jeff Niemann | Erik Bedard | | 444 | 420 | 24 |
| 2011-07-30 | @ SEA | 106 | L 2-3 | 55-51 | 4 | 24,985 | Alex Cobb | Michael Pineda | Michael Pineda | Alex Cobb | Brandon League | 446 | 423 | 23 |
| 2011-07-31 | @ SEA | 107 | W 8-1 | 56-51 | 3 | 20,382 | Jeremy Hellickson | Jason Vargas | Jeremy Hellickson | Jason Vargas | | 454 | 424 | 30 |
| 2011-08-02 | vs TOR | 108 | L 1-3 | 56-52 | 3 | 13,333 | David Price | Ricky Romero | Ricky Romero | David Price | Jon Rauch | 455 | 427 | 28 |
| 2011-08-03 | vs TOR | 109 | W 9-1 | 57-52 | 3 | 11,803 | James Shields | Carlos Villanueva | James Shields | Carlos Villanueva | | 464 | 428 | 36 |
| 2011-08-04 | vs TOR | 110 | W 7-6 | 58-52 | 3 | 28,491 | Wade Davis | Brett Cecil | Brandon Gomes | Shawn Camp | | 471 | 434 | 37 |
| 2011-08-05 | vs OAK | 111 | W 8-4 | 59-52 | 3 | 15,168 | Jeff Niemann | Guillermo Moscoso | Jeff Niemann | Guillermo Moscoso | | 479 | 438 | 41 |
| 2011-08-06 | vs OAK | 112 | L 0-8 | 59-53 | 3 | 24,939 | Alex Cobb | Brandon McCarthy | Brandon McCarthy | Alex Cobb | | 479 | 446 | 33 |
| 2011-08-07 | vs OAK | 113 | L 4-5 | 59-54 | 3 | 21,425 | David Price | Trevor Cahill | Fautino de los Santos | Jake McGee | Andrew Bailey | 483 | 451 | 32 |
| 2011-08-08 | vs KCA | 114 | W 2-1 | 60-54 | 3 | 10,742 | Jeremy Hellickson | Luke Hochevar | Kyle Farnsworth | Blake Wood | | 485 | 452 | 33 |
| 2011-08-09 | vs KCA | 115 | W 4-0 | 61-54 | 3 | 10,124 | James Shields | Jeff Francis | James Shields | Jeff Francis | | 489 | 452 | 37 |
| 2011-08-10 | vs KCA | 116 | W 8-7 | 62-54 | 3 | 11,706 | Wade Davis | Felipe Paulino | Jake McGee | Joakim Soria | | 497 | 459 | 38 |
| 2011-08-11 | vs KCA | 117 | W 4-1 | 63-54 | 3 | 13,942 | Jeff Niemann | Danny Duffy | Jeff Niemann | Danny Duffy | Kyle Farnsworth | 501 | 460 | 41 |
| 2011-08-12 | @ NYA | 118 | W 5-1 | 64-54 | 3 | 47,894 | David Price | CC Sabathia | David Price | CC Sabathia | | 506 | 461 | 45 |
| 2011-08-13 | @ NYA | 119 | L 2-9 | 64-55 | 3 | 47,804 | Jeremy Hellickson | Phil Hughes | Phil Hughes | Jeremy Hellickson | | 508 | 470 | 38 |
| 2011-08-16 | @ BOS | 120 | L 1-3 | 64-56 | 5 | 38,525 | James Shields | Jon Lester | Jon Lester | James Shields | Jonathan Papelbon | 509 | 473 | 36 |
| 2011-08-16 | @ BOS | 121 | W 6-2 | 64-56 | 5 | 38,278 | Jeff Niemann | Erik Bedard | Jeff Niemann | Erik Bedard | | 515 | 475 | 40 |
| 2011-08-17 | @ BOS | 122 | W 4-0 | 66-56 | 3 | 37,747 | David Price | John Lackey | David Price | John Lackey | | 519 | 475 | 44 |
| 2011-08-19 | vs SEA | 123 | W 3-2 | 67-56 | 3 | 14,884 | Wade Davis | Felix Hernandez | Juan Cruz | Felix Hernandez | Kyle Farnsworth | 522 | 477 | 45 |
| 2011-08-20 | vs SEA | 124 | W 8-0 | 68-56 | 3 | 20,148 | Jeremy Hellickson | Charlie Furbush | Jeremy Hellickson | Charlie Furbush | | 530 | 477 | 53 |
| 2011-08-21 | vs SEA | 125 | W 8-7 | 69-56 | 3 | 17,226 | James Shields | Michael Pineda | Kyle Farnsworth | Dan Cortes | | 538 | 484 | 54 |
| 2011-08-22 | vs DET | 126 | L 2-5 | 69-57 | 3 | 13,048 | Jeff Niemann | Justin Verlander | Justin Verlander | Jeff Niemann | | 540 | 489 | 51 |
| 2011-08-23 | vs DET | 127 | L 1-2 | 69-58 | 3 | 11,475 | David Price | Brad Penny | Brad Penny | David Price | Phil Coke | 541 | 491 | 50 |
| 2011-08-24 | vs DET | 128 | W 3-2 | 70-58 | 3 | 13,910 | Wade Davis | Max Scherzer | Joel Peralta | Duane Below | | 544 | 493 | 51 |
| 2011-08-25 | vs DET | 129 | L 0-2 | 70-59 | 3 | 14,069 | Jeremy Hellickson | Doug Fister | Doug Fister | Jeremy Hellickson | Jose Valverde | 544 | 495 | 49 |
| 2011-08-26 | @ TOR | 130 | W 6-1 | 71-59 | 3 | 20,491 | James Shields | Henderson Alvarez | James Shields | Henderson Alvarez | | 550 | 496 | 54 |
| 2011-08-27 | @ TOR | 131 | W 6-5 | 72-59 | 4 | 24,052 | Jeff Niemann | Luis Perez | Jeff Niemann | Shawn Camp | Joel Peralta | 556 | 501 | 55 |
| 2011-08-28 | @ TOR | 132 | W 12-0 | 73-59 | 4 | 21,618 | David Price | Brandon Morrow | David Price | Brandon Morrow | | 568 | 501 | 67 |
| 2011-08-29 | @ TOR | 133 | L 3-7 | 73-60 | 3 | 19,725 | Wade Davis | Ricky Romero | Ricky Romero | Wade Davis | | 571 | 508 | 63 |
| 2011-08-30 | @ TEX | 134 | L 0-2 | 73-61 | 3 | 23,069 | Jeremy Hellickson | Scott Feldman | Scott Feldman | Jeremy Hellickson | Neftali Feliz | 571 | 510 | 61 |
| 2011-08-31 | @ TEX | 135 | W 4-1 | 74-61 | 3 | 28,034 | James Shields | Alexi Ogando | James Shields | Alexi Ogando | | 575 | 511 | 64 |
| 2011-09-01 | @ TEX | 136 | L 2-7 | 74-62 | 3 | 26,220 | Jeff Niemann | C.J. Wilson | C.J. Wilson | Jeff Niemann | | 577 | 518 | 59 |
| 2011-09-02 | vs BAL | 137 | L 2-3 | 74-63 | 3 | 11,955 | David Price | Zachary Britton | Zachary Britton | David Price | Kevin Gregg | 579 | 521 | 58 |
| 2011-09-03 | vs BAL | 138 | W 6-3 | 75-63 | 3 | 14,223 | Wade Davis | Alfredo Simon | Wade Davis | Alfredo Simon | Kyle Farnsworth | 585 | 524 | 61 |
| 2011-09-04 | vs BAL | 139 | W 8-1 | 76-63 | 3 | 15,790 | Jeremy Hellickson | Jeremy Guthrie | Jeremy Hellickson | Jeremy Guthrie | | 593 | 525 | 68 |
| 2011-09-05 | vs TEX | 140 | W 5-1 | 77-63 | 3 | 13,130 | James Shields | Scott Feldman | James Shields | Scott Feldman | | 598 | 526 | 72 |
| 2011-09-06 | vs TEX | 141 | L 0-8 | 77-64 | 3 | 11,611 | Jeff Niemann | C.J. Wilson | C.J. Wilson | Jeff Niemann | | 598 | 534 | 64 |
| 2011-09-07 | vs TEX | 142 | W 5-4 | 78-64 | 3 | 11,190 | David Price | Derek Holland | Jake McGee | Mark Lowe | | 603 | 538 | 65 |
| 2011-09-09 | vs BOS | 143 | W 7-2 | 79-64 | 3 | 18,482 | Wade Davis | John Lackey | Wade Davis | John Lackey | | 610 | 540 | 70 |
| 2011-09-10 | vs BOS | 144 | W 6-5 | 80-64 | 3 | 24,566 | Jeremy Hellickson | Kyle Weiland | Brandon Gomes | Daniel Bard | | 616 | 545 | 71 |
| 2011-09-11 | vs BOS | 145 | W 9-1 | 81-64 | 3 | 25,220 | James Shields | Jon Lester | James Shields | Jon Lester | | 625 | 546 | 79 |
| 2011-09-12 | @ BAL | 146 | W 5-2 | 82-64 | 3 | 11,924 | Jeff Niemann | Zachary Britton | Jeff Niemann | Zachary Britton | Joel Peralta | 630 | 548 | 82 |
| 2011-09-13 | @ BAL | 147 | L 2-4 | 82-65 | 3 | 13,262 | David Price | Alfredo Simon | Troy Patton | J.P. Howell | Jim Johnson | 632 | 552 | 80 |
| 2011-09-14 | @ BAL | 148 | L 2-6 | 82-66 | 3 | 14,669 | Wade Davis | Jeremy Guthrie | Jeremy Guthrie | Wade Davis | Jim Johnson | 634 | 558 | 76 |
| 2011-09-15 | @ BOS | 149 | W 9-2 | 83-66 | 3 | 38,071 | Jeremy Hellickson | Kyle Weiland | Jeremy Hellickson | Kyle Weiland | | 643 | 560 | 83 |
| 2011-09-16 | @ BOS | 150 | L 3-4 | 83-67 | 3 | 38,019 | James Shields | Josh Beckett | Josh Beckett | James Shields | Jonathan Papelbon | 646 | 564 | 82 |
| 2011-09-17 | @ BOS | 151 | W 4-3 | 84-67 | 3 | 37,682 | Jeff Niemann | Jon Lester | Jeff Niemann | Jon Lester | Joel Peralta | 650 | 567 | 83 |
| 2011-09-18 | @ BOS | 152 | W 8-5 | 85-67 | 3 | 37,613 | David Price | Tim Wakefield | Jake McGee | Tim Wakefield | Joel Peralta | 658 | 572 | 86 |
| 2011-09-20 | @ NYA | 153 | L 0-5 | 85-68 | 3 | 46,944 | Wade Davis | Ivan Nova | Ivan Nova | Wade Davis | | 658 | 577 | 81 |
| 2011-09-21 | @ NYA | 154 | L 2-4 | 85-70 | 5 | 42,755 | James Shields | Hector Noesi | Luis Ayala | James Shields | Mariano Rivera | 660 | 581 | 79 |
| 2011-09-21 | @ NYA | 155 | L 2-4 | 85-70 | 5 | 45,586 | Jeremy Hellickson | CC Sabathia | David Robertson | Jake McGee | Rafael Soriano | 662 | 585 | 77 |
| 2011-09-22 | @ NYA | 156 | W 15-8 | 86-70 | 3 | 47,470 | Matt Moore | Bartolo Colon | Matt Moore | Bartolo Colon | | 677 | 593 | 84 |
| 2011-09-23 | vs TOR | 157 | L 1-5 | 86-71 | 3 | 18,093 | David Price | Brandon Morrow | Brandon Morrow | David Price | | 678 | 598 | 80 |
| 2011-09-24 | vs TOR | 158 | W 6-2 | 87-71 | 3 | 27,773 | Jeff Niemann | Ricky Romero | Alexander Torres | Ricky Romero | | 684 | 600 | 84 |
| 2011-09-25 | vs TOR | 159 | W 5-2 | 88-71 | 5 | 21,008 | Wade Davis | Brett Cecil | Wade Davis | Brett Cecil | Joel Peralta | 689 | 602 | 87 |
| 2011-09-26 | vs NYA | 160 | W 5-2 | 89-71 | 3 | 18,772 | James Shields | Hector Noesi | James Shields | Hector Noesi | Kyle Farnsworth | 694 | 604 | 90 |
| 2011-09-27 | vs NYA | 161 | W 5-3 | 90-71 | 3 | 22,820 | Jeremy Hellickson | Bartolo Colon | Jake McGee | Rafael Soriano | Kyle Farnsworth | 699 | 607 | 92 |
| 2011-09-28 | vs NYA | 162 | W 8-7 | 91-71 | 2 | 29,518 | David Price | Dellin Betances | Jake McGee | Scott Proctor | | 707 | 614 | 93 |