| West | W | L | Pct | GB |
| Texas | 96 | 66 | .593 | -- |
| LA Angels | 86 | 76 | .531 | 10.0 |
| Oakland | 74 | 88 | .457 | 22.0 |
| Seattle | 67 | 95 | .414 | 29.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2011-04-01 | Felix Hernandez | R | 25 | W 6-2 | @ OAK | 1 | 173 | W | 9.0 | 5 | 2 | 2 | 1 | 0 | 5 | 108 | 35 | 73 | 68% | 1-0 | 2.00 | 0.56 |
| 2011-04-02 | Jason Vargas | L | 28 | W 5-2 | @ OAK | 1 | 67 | - | 6.2 | 5 | 1 | 1 | 0 | 1 | 6 | 92 | 33 | 59 | 64% | 0-0 | 1.29 | 0.86 |
| 2011-04-03 | Doug Fister | R | 27 | L 1-7 | @ OAK | 1 | 39 | L | 5.2 | 8 | 3 | 2 | 0 | 0 | 2 | 97 | 33 | 64 | 66% | 0-1 | 3.00 | 1.33 |
| 2011-04-04 | Erik Bedard | L | 32 | L 4-6 | @ TEX | 1 | 142 | L | 5.0 | 4 | 5 | 3 | 2 | 2 | 3 | 99 | 37 | 62 | 63% | 0-1 | 5.40 | 1.20 |
| 2011-04-05 | Michael Pineda | R | 22 | L 2-3 | @ TEX | 1 | 1 | L | 6.0 | 5 | 3 | 3 | 0 | 1 | 4 | 84 | 27 | 57 | 68% | 0-1 | 4.50 | 1.00 |
| 2011-04-06 | Felix Hernandez | R | 25 | L 3-7 | @ TEX | 2 | 174 | L | 7.0 | 6 | 4 | 2 | 0 | 3 | 6 | 110 | 41 | 69 | 63% | 1-1 | 2.25 | 0.88 |
| 2011-04-08 | Jason Vargas | L | 28 | W 3-12 | vs CLE | 2 | 68 | L | 3.1 | 9 | 7 | 7 | 1 | 0 | 1 | 63 | 26 | 37 | 59% | 0-1 | 7.20 | 1.50 |
| 2011-04-09 | Doug Fister | R | 27 | W 1-2 | vs CLE | 2 | 40 | L | 6.0 | 6 | 2 | 1 | 0 | 2 | 3 | 105 | 39 | 66 | 63% | 0-2 | 2.25 | 1.33 |
| 2011-04-10 | Erik Bedard | L | 32 | W 4-6 | vs CLE | 2 | 143 | L | 4.0 | 10 | 6 | 6 | 2 | 1 | 6 | 83 | 26 | 57 | 69% | 0-2 | 9.00 | 1.89 |
| 2011-04-11 | Felix Hernandez | R | 25 | L 8-7 | vs TOR | 3 | 175 | - | 6.0 | 12 | 7 | 7 | 1 | 2 | 6 | 108 | 38 | 70 | 65% | 1-1 | 4.50 | 1.27 |
| 2011-04-12 | Michael Pineda | R | 22 | L 3-2 | vs TOR | 2 | 2 | W | 7.1 | 5 | 2 | 1 | 0 | 2 | 7 | 103 | 29 | 74 | 72% | 1-1 | 2.77 | 1.00 |
| 2011-04-13 | Jason Vargas | L | 28 | W 3-8 | vs TOR | 3 | 69 | - | 6.2 | 5 | 1 | 1 | 0 | 1 | 7 | 105 | 41 | 64 | 61% | 0-1 | 4.76 | 1.24 |
| 2011-04-14 | Doug Fister | R | 27 | L 1-5 | @ KCA | 3 | 41 | L | 7.0 | 8 | 5 | 5 | 1 | 1 | 5 | 106 | 35 | 71 | 67% | 0-3 | 3.79 | 1.32 |
| 2011-04-15 | Erik Bedard | L | 32 | L 5-6 | @ KCA | 3 | 144 | L | 4.2 | 7 | 5 | 4 | 2 | 3 | 6 | 105 | 37 | 68 | 65% | 0-3 | 8.36 | 1.93 |
| 2011-04-16 | Felix Hernandez | R | 25 | L 0-7 | @ KCA | 4 | 176 | L | 5.0 | 6 | 5 | 2 | 0 | 2 | 6 | 95 | 34 | 61 | 64% | 1-2 | 4.33 | 1.33 |
| 2011-04-17 | Michael Pineda | R | 22 | W 3-2 | @ KCA | 3 | 3 | W | 6.0 | 3 | 1 | 1 | 0 | 4 | 5 | 99 | 35 | 64 | 65% | 2-1 | 2.37 | 1.05 |
| 2011-04-18 | Jason Vargas | L | 28 | W 3-8 | vs DET | 4 | 70 | - | 6.0 | 6 | 2 | 2 | 0 | 2 | 4 | 114 | 37 | 77 | 68% | 0-1 | 4.30 | 1.26 |
| 2011-04-19 | Doug Fister | R | 27 | L 13-3 | vs DET | 4 | 42 | W | 6.1 | 5 | 2 | 2 | 0 | 2 | 7 | 109 | 37 | 72 | 66% | 1-3 | 3.60 | 1.28 |
| 2011-04-20 | Erik Bedard | L | 32 | W 2-3 | vs DET | 4 | 145 | L | 5.0 | 5 | 3 | 3 | 1 | 5 | 2 | 95 | 44 | 51 | 54% | 0-4 | 7.58 | 1.95 |
| 2011-04-21 | Felix Hernandez | R | 25 | L 1-0 | vs OAK | 5 | 177 | W | 7.2 | 4 | 0 | 0 | 0 | 3 | 8 | 125 | 53 | 72 | 58% | 2-2 | 3.34 | 1.23 |
| 2011-04-22 | Michael Pineda | R | 22 | L 4-0 | vs OAK | 4 | 4 | W | 6.0 | 5 | 0 | 0 | 0 | 2 | 5 | 97 | 31 | 66 | 68% | 3-1 | 1.80 | 1.08 |
| 2011-04-23 | Jason Vargas | L | 28 | W 1-9 | vs OAK | 5 | 71 | L | 5.0 | 6 | 6 | 6 | 1 | 3 | 3 | 100 | 36 | 64 | 64% | 0-2 | 5.46 | 1.36 |
| 2011-04-24 | Doug Fister | R | 27 | W 2-5 | vs OAK | 5 | 43 | - | 6.0 | 4 | 1 | 1 | 0 | 2 | 5 | 108 | 43 | 65 | 60% | 1-3 | 3.19 | 1.23 |
| 2011-04-26 | Felix Hernandez | R | 25 | W 7-3 | @ DET | 6 | 178 | W | 6.0 | 4 | 3 | 2 | 0 | 2 | 4 | 104 | 43 | 61 | 59% | 3-2 | 3.29 | 1.20 |
| 2011-04-27 | Erik Bedard | L | 32 | W 10-1 | @ DET | 5 | 146 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 3 | 87 | 28 | 59 | 68% | 1-4 | 5.88 | 1.62 |
| 2011-04-28 | Michael Pineda | R | 22 | W 7-2 | @ DET | 5 | 5 | W | 6.0 | 4 | 2 | 2 | 0 | 3 | 9 | 102 | 37 | 65 | 64% | 4-1 | 2.03 | 1.10 |
| 2011-04-29 | Jason Vargas | L | 28 | W 5-4 | @ BOS | 6 | 72 | W | 7.0 | 8 | 4 | 4 | 2 | 2 | 4 | 102 | 40 | 62 | 61% | 1-2 | 5.40 | 1.37 |
| 2011-04-30 | Doug Fister | R | 27 | W 2-0 | @ BOS | 6 | 44 | W | 5.2 | 5 | 0 | 0 | 0 | 5 | 4 | 108 | 47 | 61 | 56% | 2-3 | 2.68 | 1.30 |
| 2011-05-01 | Felix Hernandez | R | 25 | L 2-3 | @ BOS | 7 | 179 | - | 7.0 | 6 | 2 | 2 | 0 | 1 | 10 | 113 | 41 | 72 | 64% | 3-2 | 3.19 | 1.17 |
| 2011-05-03 | Erik Bedard | L | 32 | L 4-3 | vs TEX | 6 | 147 | - | 7.0 | 2 | 2 | 2 | 0 | 2 | 3 | 102 | 38 | 64 | 63% | 1-4 | 5.18 | 1.39 |
| 2011-05-04 | Michael Pineda | R | 22 | W 2-5 | vs TEX | 6 | 6 | L | 7.0 | 7 | 4 | 4 | 2 | 0 | 9 | 96 | 19 | 77 | 80% | 4-2 | 2.61 | 1.08 |
| 2011-05-05 | Jason Vargas | L | 28 | L 3-1 | vs TEX | 7 | 73 | W | 7.2 | 6 | 1 | 1 | 0 | 2 | 3 | 98 | 35 | 63 | 64% | 2-2 | 4.71 | 1.33 |
| 2011-05-06 | Felix Hernandez | R | 25 | L 3-2 | vs CHA | 8 | 180 | W | 9.0 | 5 | 2 | 2 | 1 | 2 | 6 | 107 | 39 | 68 | 64% | 4-2 | 3.00 | 1.11 |
| 2011-05-07 | Doug Fister | R | 27 | W 0-6 | vs CHA | 7 | 45 | L | 5.2 | 14 | 5 | 5 | 0 | 0 | 1 | 78 | 21 | 57 | 73% | 2-4 | 3.43 | 1.48 |
| 2011-05-08 | Erik Bedard | L | 32 | W 2-5 | vs CHA | 7 | 148 | - | 5.0 | 5 | 2 | 1 | 0 | 2 | 9 | 99 | 30 | 69 | 70% | 1-4 | 4.74 | 1.39 |
| 2011-05-10 | Michael Pineda | R | 22 | L 6-7 | @ BAL | 7 | 7 | - | 6.0 | 7 | 3 | 3 | 1 | 1 | 6 | 98 | 28 | 70 | 71% | 4-2 | 2.86 | 1.11 |
| 2011-05-11 | Felix Hernandez | R | 25 | L 2-4 | @ BAL | 9 | 181 | L | 5.0 | 7 | 4 | 4 | 0 | 3 | 4 | 105 | 38 | 67 | 64% | 4-3 | 3.34 | 1.18 |
| 2011-05-12 | Jason Vargas | L | 28 | L 1-2 | @ BAL | 8 | 74 | - | 9.0 | 7 | 0 | 0 | 0 | 1 | 4 | 102 | 34 | 68 | 67% | 2-2 | 3.88 | 1.25 |
| 2011-05-13 | Doug Fister | R | 27 | L 4-5 | @ CLE | 8 | 46 | - | 8.0 | 4 | 2 | 2 | 2 | 1 | 6 | 110 | 32 | 78 | 71% | 2-4 | 3.24 | 1.34 |
| 2011-05-16 | Michael Pineda | R | 22 | L 5-2 | vs MIN | 8 | 8 | W | 7.0 | 3 | 0 | 0 | 0 | 0 | 7 | 98 | 29 | 69 | 70% | 5-2 | 2.47 | 1.02 |
| 2011-05-17 | Felix Hernandez | R | 25 | W 1-2 | vs MIN | 10 | 182 | L | 8.0 | 3 | 2 | 2 | 0 | 3 | 9 | 109 | 43 | 66 | 61% | 4-4 | 3.21 | 1.13 |
| 2011-05-18 | Jason Vargas | L | 28 | L 3-0 | vs ANA | 9 | 75 | W | 7.0 | 4 | 0 | 0 | 0 | 2 | 9 | 114 | 40 | 74 | 65% | 3-2 | 3.41 | 1.21 |
| 2011-05-19 | Doug Fister | R | 27 | L 2-1 | vs ANA | 9 | 47 | - | 8.0 | 6 | 1 | 1 | 1 | 2 | 2 | 110 | 31 | 79 | 72% | 2-4 | 2.95 | 1.29 |
| 2011-05-20 | Erik Bedard | L | 32 | W 4-1 | @ SDN | 8 | 149 | W | 8.0 | 3 | 0 | 0 | 0 | 2 | 9 | 96 | 29 | 67 | 70% | 2-4 | 3.91 | 1.26 |
| 2011-05-21 | Michael Pineda | R | 22 | W 4-0 | @ SDN | 9 | 9 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 9 | 98 | 31 | 67 | 68% | 6-2 | 2.17 | 0.95 |
| 2011-05-22 | Felix Hernandez | R | 25 | W 6-1 | @ SDN | 11 | 183 | W | 8.0 | 6 | 1 | 1 | 0 | 0 | 13 | 110 | 39 | 71 | 65% | 5-4 | 3.00 | 1.09 |
| 2011-05-23 | Jason Vargas | L | 28 | W 8-7 | @ MIN | 10 | 76 | - | 4.2 | 7 | 5 | 5 | 2 | 4 | 2 | 95 | 36 | 59 | 62% | 3-2 | 3.86 | 1.29 |
| 2011-05-24 | Doug Fister | R | 27 | L 2-4 | @ MIN | 10 | 48 | L | 6.2 | 9 | 4 | 4 | 0 | 0 | 6 | 110 | 34 | 76 | 69% | 2-5 | 3.18 | 1.29 |
| 2011-05-25 | Erik Bedard | L | 32 | W 3-0 | @ MIN | 9 | 150 | W | 6.0 | 6 | 0 | 0 | 0 | 1 | 4 | 96 | 35 | 61 | 64% | 3-4 | 3.46 | 1.25 |
| 2011-05-27 | Michael Pineda | R | 22 | L 4-3 | vs NYA | 10 | 10 | - | 5.0 | 3 | 3 | 3 | 1 | 5 | 5 | 96 | 41 | 55 | 57% | 6-2 | 2.43 | 1.00 |
| 2011-05-28 | Felix Hernandez | R | 25 | L 5-4 | vs NYA | 12 | 184 | - | 7.0 | 6 | 4 | 4 | 2 | 5 | 4 | 127 | 53 | 74 | 58% | 5-4 | 3.18 | 1.13 |
| 2011-05-29 | Jason Vargas | L | 28 | W 1-7 | vs NYA | 11 | 77 | L | 3.0 | 5 | 6 | 6 | 1 | 4 | 1 | 82 | 32 | 50 | 61% | 3-3 | 4.50 | 1.36 |
| 2011-05-30 | Doug Fister | R | 27 | L 4-3 | vs BAL | 11 | 49 | W | 7.1 | 7 | 3 | 3 | 1 | 1 | 9 | 109 | 32 | 77 | 71% | 3-5 | 3.25 | 1.28 |
| 2011-05-31 | Erik Bedard | L | 32 | L 3-2 | vs BAL | 10 | 151 | - | 6.1 | 6 | 2 | 2 | 1 | 2 | 7 | 99 | 34 | 65 | 66% | 3-4 | 3.41 | 1.26 |
| 2011-06-01 | Michael Pineda | R | 22 | W 1-2 | vs BAL | 11 | 11 | - | 7.0 | 6 | 1 | 1 | 1 | 1 | 7 | 104 | 32 | 72 | 69% | 6-2 | 2.31 | 1.00 |
| 2011-06-02 | Felix Hernandez | R | 25 | L 8-2 | vs TBA | 13 | 185 | W | 7.0 | 5 | 1 | 1 | 0 | 2 | 11 | 95 | 33 | 62 | 65% | 6-4 | 3.03 | 1.12 |
| 2011-06-03 | Jason Vargas | L | 28 | L 7-0 | vs TBA | 12 | 78 | W | 9.0 | 4 | 0 | 0 | 0 | 1 | 4 | 113 | 37 | 76 | 67% | 4-3 | 3.96 | 1.27 |
| 2011-06-04 | Doug Fister | R | 27 | W 2-3 | vs TBA | 12 | 50 | L | 7.0 | 7 | 3 | 3 | 0 | 4 | 6 | 110 | 41 | 69 | 63% | 3-6 | 3.30 | 1.30 |
| 2011-06-05 | Erik Bedard | L | 32 | L 9-6 | vs TBA | 11 | 152 | - | 7.0 | 8 | 3 | 3 | 0 | 0 | 7 | 104 | 40 | 64 | 62% | 3-4 | 3.46 | 1.25 |
| 2011-06-06 | Michael Pineda | R | 22 | L 1-3 | @ CHA | 12 | 12 | L | 7.0 | 5 | 2 | 2 | 1 | 2 | 3 | 95 | 32 | 63 | 66% | 6-3 | 2.34 | 1.00 |
| 2011-06-07 | Felix Hernandez | R | 25 | L 1-5 | @ CHA | 14 | 186 | L | 6.2 | 8 | 5 | 5 | 2 | 2 | 5 | 114 | 39 | 75 | 66% | 6-5 | 3.31 | 1.15 |
| 2011-06-08 | Jason Vargas | L | 28 | W 7-4 | @ CHA | 13 | 79 | - | 7.1 | 7 | 3 | 3 | 1 | 1 | 4 | 95 | 28 | 67 | 71% | 4-3 | 3.95 | 1.26 |
| 2011-06-09 | Doug Fister | R | 27 | L 1-4 | @ DET | 13 | 51 | L | 8.0 | 7 | 4 | 4 | 1 | 2 | 3 | 87 | 26 | 61 | 70% | 3-7 | 3.41 | 1.29 |
| 2011-06-10 | Erik Bedard | L | 32 | W 3-2 | @ DET | 12 | 153 | - | 5.0 | 3 | 2 | 2 | 1 | 3 | 6 | 95 | 36 | 59 | 62% | 3-4 | 3.47 | 1.24 |
| 2011-06-11 | Michael Pineda | R | 22 | L 1-8 | @ DET | 13 | 13 | L | 5.1 | 8 | 6 | 5 | 1 | 1 | 4 | 87 | 31 | 56 | 64% | 6-4 | 2.71 | 1.04 |
| 2011-06-12 | Felix Hernandez | R | 25 | W 7-3 | @ DET | 15 | 187 | W | 8.0 | 9 | 3 | 3 | 0 | 5 | 6 | 129 | 53 | 76 | 59% | 7-5 | 3.31 | 1.20 |
| 2011-06-13 | Jason Vargas | L | 28 | W 3-6 | vs ANA | 14 | 80 | L | 7.0 | 6 | 5 | 5 | 2 | 2 | 6 | 107 | 31 | 76 | 71% | 4-4 | 4.15 | 1.25 |
| 2011-06-14 | Doug Fister | R | 27 | W 0-4 | vs ANA | 14 | 52 | L | 7.0 | 7 | 4 | 4 | 0 | 1 | 5 | 107 | 36 | 71 | 66% | 3-8 | 3.54 | 1.28 |
| 2011-06-15 | Erik Bedard | L | 32 | L 3-1 | vs ANA | 13 | 154 | W | 7.0 | 3 | 0 | 0 | 0 | 0 | 5 | 94 | 28 | 66 | 70% | 4-4 | 3.16 | 1.17 |
| 2011-06-17 | Michael Pineda | R | 22 | L 4-2 | vs PHI | 14 | 14 | W | 6.0 | 2 | 1 | 1 | 0 | 3 | 5 | 86 | 33 | 53 | 62% | 7-4 | 2.63 | 1.02 |
| 2011-06-18 | Felix Hernandez | R | 25 | W 1-5 | vs PHI | 16 | 188 | L | 7.0 | 8 | 3 | 3 | 0 | 2 | 5 | 117 | 42 | 75 | 64% | 7-6 | 3.35 | 1.21 |
| 2011-06-19 | Jason Vargas | L | 28 | L 2-0 | vs PHI | 15 | 81 | W | 9.0 | 3 | 0 | 0 | 0 | 2 | 6 | 117 | 35 | 82 | 70% | 5-4 | 3.77 | 1.18 |
| 2011-06-21 | Doug Fister | R | 27 | L 5-6 | @ WAS | 15 | 53 | - | 8.0 | 3 | 1 | 1 | 0 | 1 | 3 | 98 | 34 | 64 | 65% | 3-8 | 3.35 | 1.22 |
| 2011-06-22 | Erik Bedard | L | 32 | L 1-2 | @ WAS | 14 | 155 | L | 6.0 | 3 | 2 | 0 | 0 | 2 | 10 | 89 | 28 | 61 | 69% | 4-5 | 2.93 | 1.14 |
| 2011-06-23 | Michael Pineda | R | 22 | L 0-1 | @ WAS | 15 | 15 | - | 7.0 | 4 | 0 | 0 | 0 | 1 | 9 | 95 | 28 | 67 | 71% | 7-4 | 2.44 | 1.00 |
| 2011-06-24 | Felix Hernandez | R | 25 | W 5-1 | @ FLO | 17 | 189 | W | 8.0 | 2 | 1 | 1 | 0 | 2 | 10 | 116 | 39 | 77 | 66% | 8-6 | 3.20 | 1.17 |
| 2011-06-25 | Jason Vargas | L | 28 | L 2-4 | @ FLO | 16 | 82 | L | 6.0 | 8 | 4 | 4 | 0 | 2 | 4 | 87 | 28 | 59 | 68% | 5-5 | 3.89 | 1.21 |
| 2011-06-26 | Doug Fister | R | 27 | W 2-1 | @ FLO | 16 | 54 | - | 8.0 | 8 | 1 | 1 | 0 | 0 | 3 | 118 | 30 | 88 | 75% | 3-8 | 3.19 | 1.20 |
| 2011-06-27 | Erik Bedard | L | 32 | W 1-3 | vs ATL | 15 | 156 | L | 7.0 | 4 | 3 | 3 | 2 | 1 | 5 | 103 | 39 | 64 | 62% | 4-6 | 3.00 | 1.11 |
| 2011-06-28 | Michael Pineda | R | 22 | W 4-5 | vs ATL | 16 | 16 | L | 6.1 | 4 | 5 | 4 | 1 | 5 | 5 | 89 | 37 | 52 | 58% | 7-5 | 2.65 | 1.03 |
| 2011-06-29 | Felix Hernandez | R | 25 | W 3-5 | vs ATL | 18 | 190 | L | 7.2 | 10 | 5 | 5 | 0 | 3 | 6 | 127 | 47 | 80 | 63% | 8-7 | 3.35 | 1.19 |
| 2011-07-01 | Jason Vargas | L | 28 | L 6-0 | vs SDN | 17 | 83 | W | 9.0 | 6 | 0 | 0 | 0 | 0 | 7 | 106 | 31 | 75 | 71% | 6-5 | 3.58 | 1.17 |
| 2011-07-02 | Doug Fister | R | 27 | W 0-1 | vs SDN | 17 | 55 | L | 9.0 | 6 | 1 | 1 | 0 | 1 | 7 | 112 | 31 | 81 | 72% | 3-9 | 3.03 | 1.17 |
| 2011-07-03 | Blake Beavan | R | 22 | L 3-1 | vs SDN | 1 | 1 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 4 | 86 | 26 | 60 | 70% | 1-0 | 1.29 | 0.71 |
| 2011-07-04 | Michael Pineda | R | 22 | W 2-1 | @ OAK | 17 | 17 | W | 6.0 | 2 | 1 | 1 | 0 | 2 | 7 | 92 | 32 | 60 | 65% | 8-5 | 2.58 | 1.01 |
| 2011-07-05 | Felix Hernandez | R | 25 | W 4-2 | @ OAK | 19 | 191 | - | 8.0 | 4 | 1 | 1 | 1 | 0 | 10 | 134 | 46 | 88 | 66% | 8-7 | 3.22 | 1.15 |
| 2011-07-06 | Jason Vargas | L | 28 | L 0-2 | @ OAK | 18 | 84 | L | 8.0 | 5 | 2 | 2 | 1 | 1 | 6 | 108 | 34 | 74 | 69% | 6-6 | 3.50 | 1.14 |
| 2011-07-07 | Doug Fister | R | 27 | L 1-5 | @ ANA | 18 | 56 | L | 6.0 | 7 | 3 | 3 | 0 | 1 | 2 | 100 | 38 | 62 | 62% | 3-10 | 3.10 | 1.18 |
| 2011-07-08 | Blake Beavan | R | 22 | L 3-4 | @ ANA | 2 | 2 | - | 6.1 | 6 | 2 | 2 | 2 | 0 | 1 | 97 | 32 | 65 | 67% | 1-0 | 2.08 | 0.85 |
| 2011-07-09 | Michael Pineda | R | 22 | L 3-9 | @ ANA | 18 | 18 | L | 5.0 | 6 | 7 | 7 | 2 | 2 | 7 | 92 | 32 | 60 | 65% | 8-6 | 3.03 | 1.04 |
| 2011-07-10 | Felix Hernandez | R | 25 | L 2-4 | @ ANA | 20 | 192 | - | 7.0 | 6 | 2 | 2 | 1 | 1 | 6 | 109 | 38 | 71 | 65% | 8-7 | 3.19 | 1.15 |
| 2011-07-14 | Jason Vargas | L | 28 | W 0-5 | vs TEX | 19 | 85 | L | 6.0 | 12 | 5 | 5 | 3 | 1 | 3 | 105 | 37 | 68 | 65% | 6-7 | 3.69 | 1.19 |
| 2011-07-15 | Doug Fister | R | 27 | W 0-4 | vs TEX | 19 | 57 | L | 7.2 | 6 | 4 | 4 | 0 | 2 | 1 | 107 | 37 | 70 | 65% | 3-11 | 3.18 | 1.17 |
| 2011-07-16 | Felix Hernandez | R | 25 | W 1-5 | vs TEX | 21 | 193 | L | 7.2 | 9 | 4 | 4 | 2 | 1 | 6 | 117 | 42 | 75 | 64% | 8-8 | 3.26 | 1.15 |
| 2011-07-17 | Blake Beavan | R | 22 | W 1-3 | vs TEX | 3 | 3 | L | 6.2 | 6 | 3 | 3 | 1 | 2 | 3 | 103 | 38 | 65 | 63% | 1-1 | 2.70 | 0.95 |
| 2011-07-19 | Michael Pineda | R | 22 | L 5-6 | @ TOR | 19 | 19 | - | 6.1 | 7 | 5 | 5 | 1 | 2 | 6 | 100 | 37 | 63 | 63% | 8-6 | 3.25 | 1.06 |
| 2011-07-20 | Jason Vargas | L | 28 | L 6-11 | @ TOR | 20 | 86 | L | 3.0 | 6 | 5 | 5 | 0 | 5 | 0 | 90 | 42 | 48 | 53% | 6-8 | 3.95 | 1.25 |
| 2011-07-21 | Doug Fister | R | 27 | L 5-7 | @ TOR | 20 | 58 | - | 6.0 | 5 | 5 | 4 | 0 | 3 | 4 | 107 | 44 | 63 | 59% | 3-11 | 3.30 | 1.17 |
| 2011-07-22 | Felix Hernandez | R | 25 | L 4-7 | @ BOS | 22 | 194 | L | 6.1 | 11 | 6 | 6 | 1 | 4 | 2 | 121 | 50 | 71 | 59% | 8-9 | 3.47 | 1.20 |
| 2011-07-23 | Blake Beavan | R | 23 | L 1-3 | @ BOS | 4 | 4 | L | 6.2 | 9 | 3 | 3 | 0 | 0 | 4 | 103 | 33 | 70 | 68% | 1-2 | 3.00 | 1.04 |
| 2011-07-24 | Michael Pineda | R | 23 | L 8-12 | @ BOS | 20 | 20 | L | 4.1 | 8 | 7 | 7 | 1 | 1 | 4 | 89 | 34 | 55 | 62% | 8-7 | 3.63 | 1.09 |
| 2011-07-25 | Jason Vargas | L | 28 | L 3-10 | @ NYA | 21 | 87 | L | 4.0 | 7 | 8 | 4 | 2 | 1 | 2 | 82 | 30 | 52 | 63% | 6-9 | 4.10 | 1.27 |
| 2011-07-26 | Doug Fister | R | 27 | L 1-4 | @ NYA | 21 | 59 | L | 7.0 | 7 | 3 | 3 | 1 | 1 | 5 | 108 | 36 | 72 | 67% | 3-12 | 3.33 | 1.17 |
| 2011-07-27 | Felix Hernandez | R | 25 | W 9-2 | @ NYA | 23 | 195 | W | 7.0 | 5 | 1 | 1 | 0 | 4 | 5 | 115 | 49 | 66 | 57% | 9-9 | 3.38 | 1.21 |
| 2011-07-29 | Erik Bedard | L | 32 | W 0-8 | vs TBA | 16 | 157 | L | 1.1 | 3 | 5 | 5 | 0 | 4 | 2 | 56 | 29 | 27 | 48% | 4-7 | 3.46 | 1.18 |
| 2011-07-30 | Michael Pineda | R | 23 | L 3-2 | vs TBA | 21 | 21 | W | 6.1 | 1 | 2 | 1 | 0 | 4 | 10 | 107 | 44 | 63 | 59% | 9-7 | 3.53 | 1.08 |
| 2011-07-31 | Jason Vargas | L | 28 | W 1-8 | vs TBA | 22 | 88 | L | 5.1 | 9 | 6 | 4 | 0 | 1 | 6 | 112 | 39 | 73 | 65% | 6-10 | 4.18 | 1.29 |
| 2011-08-01 | Blake Beavan | R | 23 | L 8-4 | vs OAK | 5 | 5 | W | 6.2 | 7 | 3 | 3 | 0 | 2 | 3 | 113 | 43 | 70 | 62% | 2-2 | 3.27 | 1.12 |
| 2011-08-02 | Felix Hernandez | R | 25 | L 4-2 | vs OAK | 24 | 196 | W | 6.1 | 5 | 2 | 2 | 1 | 3 | 9 | 113 | 45 | 68 | 60% | 10-9 | 3.37 | 1.21 |
| 2011-08-03 | Charlie Furbush | L | 25 | L 7-4 | vs OAK | 3 | 3 | W | 5.0 | 2 | 1 | 1 | 0 | 0 | 3 | 62 | 18 | 44 | 71% | 2-3 | 3.55 | 1.42 |
| 2011-08-05 | Jason Vargas | L | 29 | L 0-1 | @ ANA | 23 | 89 | - | 6.0 | 7 | 0 | 0 | 0 | 1 | 3 | 111 | 44 | 67 | 60% | 6-10 | 4.01 | 1.29 |
| 2011-08-06 | Blake Beavan | R | 23 | W 5-1 | @ ANA | 6 | 6 | W | 8.0 | 8 | 1 | 1 | 0 | 0 | 2 | 108 | 34 | 74 | 69% | 3-2 | 2.85 | 1.10 |
| 2011-08-07 | Felix Hernandez | R | 25 | L 1-2 | @ ANA | 25 | 197 | L | 8.0 | 4 | 2 | 2 | 1 | 0 | 12 | 96 | 28 | 68 | 71% | 10-10 | 3.32 | 1.18 |
| 2011-08-08 | Charlie Furbush | L | 25 | L 2-9 | @ TEX | 4 | 4 | L | 4.0 | 8 | 7 | 6 | 1 | 4 | 0 | 84 | 35 | 49 | 58% | 2-4 | 4.50 | 1.57 |
| 2011-08-09 | Michael Pineda | R | 23 | L 6-7 | @ TEX | 22 | 22 | - | 6.0 | 5 | 3 | 3 | 1 | 2 | 4 | 94 | 33 | 61 | 65% | 9-7 | 3.57 | 1.08 |
| 2011-08-10 | Jason Vargas | L | 29 | W 4-3 | @ TEX | 24 | 90 | W | 7.0 | 6 | 3 | 3 | 2 | 4 | 3 | 125 | 50 | 75 | 60% | 7-10 | 4.00 | 1.29 |
| 2011-08-12 | Blake Beavan | R | 23 | W 4-6 | vs BOS | 7 | 7 | L | 6.1 | 11 | 6 | 6 | 3 | 1 | 1 | 94 | 31 | 63 | 67% | 3-3 | 3.56 | 1.19 |
| 2011-08-13 | Felix Hernandez | R | 25 | L 5-4 | vs BOS | 26 | 198 | W | 7.0 | 9 | 4 | 4 | 2 | 2 | 2 | 106 | 34 | 72 | 68% | 11-10 | 3.39 | 1.19 |
| 2011-08-14 | Charlie Furbush | L | 25 | L 5-3 | vs BOS | 5 | 5 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 6 | 95 | 37 | 58 | 61% | 3-4 | 4.04 | 1.47 |
| 2011-08-15 | Michael Pineda | R | 23 | L 6-5 | vs TOR | 23 | 23 | - | 5.0 | 6 | 5 | 5 | 3 | 4 | 6 | 92 | 38 | 54 | 59% | 9-7 | 3.77 | 1.11 |
| 2011-08-16 | Jason Vargas | L | 29 | W 7-13 | vs TOR | 25 | 91 | L | 4.0 | 7 | 8 | 8 | 1 | 4 | 2 | 94 | 39 | 55 | 59% | 7-11 | 4.36 | 1.33 |
| 2011-08-17 | Blake Beavan | R | 23 | W 1-5 | vs TOR | 8 | 8 | L | 5.0 | 6 | 5 | 5 | 3 | 2 | 3 | 95 | 36 | 59 | 62% | 3-4 | 4.08 | 1.23 |
| 2011-08-19 | Felix Hernandez | R | 25 | L 2-3 | @ TBA | 27 | 199 | L | 8.0 | 7 | 3 | 3 | 0 | 3 | 9 | 110 | 40 | 70 | 64% | 11-11 | 3.39 | 1.20 |
| 2011-08-20 | Charlie Furbush | L | 25 | L 0-8 | @ TBA | 6 | 6 | L | 3.0 | 8 | 5 | 5 | 1 | 1 | 2 | 73 | 28 | 45 | 62% | 3-5 | 4.67 | 1.56 |
| 2011-08-21 | Michael Pineda | R | 23 | L 7-8 | @ TBA | 24 | 24 | - | 6.0 | 6 | 3 | 2 | 0 | 0 | 5 | 106 | 38 | 68 | 64% | 9-7 | 3.73 | 1.11 |
| 2011-08-22 | Jason Vargas | L | 29 | W 3-2 | @ CLE | 26 | 92 | - | 7.0 | 7 | 2 | 0 | 0 | 0 | 2 | 101 | 34 | 67 | 66% | 7-11 | 4.17 | 1.32 |
| 2011-08-23 | Blake Beavan | R | 23 | L 5-7 | @ CLE | 9 | 9 | - | 6.0 | 8 | 3 | 3 | 0 | 1 | 4 | 106 | 37 | 69 | 65% | 3-4 | 4.12 | 1.25 |
| 2011-08-23 | Anthony Vasquez | L | 25 | W 12-7 | @ CLE | 1 | 1 | W | 5.1 | 9 | 6 | 5 | 2 | 2 | 2 | 98 | 35 | 63 | 64% | 1-0 | 9.00 | 2.20 |
| 2011-08-24 | Felix Hernandez | R | 25 | W 9-2 | @ CLE | 28 | 200 | W | 6.0 | 7 | 2 | 2 | 0 | 2 | 10 | 107 | 35 | 72 | 67% | 12-11 | 3.38 | 1.21 |
| 2011-08-26 | Charlie Furbush | L | 25 | W 2-4 | vs CHA | 7 | 7 | L | 5.0 | 6 | 4 | 4 | 1 | 2 | 4 | 103 | 44 | 59 | 57% | 3-6 | 4.89 | 1.56 |
| 2011-08-27 | Michael Pineda | R | 23 | W 0-3 | vs CHA | 25 | 25 | L | 6.0 | 3 | 2 | 2 | 0 | 1 | 8 | 101 | 31 | 70 | 69% | 9-8 | 3.71 | 1.09 |
| 2011-08-28 | Jason Vargas | L | 29 | W 3-9 | vs CHA | 27 | 93 | L | 5.2 | 10 | 9 | 9 | 2 | 2 | 2 | 100 | 35 | 65 | 65% | 7-12 | 4.53 | 1.35 |
| 2011-08-29 | Blake Beavan | R | 23 | L 5-3 | vs ANA | 10 | 10 | - | 7.0 | 8 | 3 | 3 | 1 | 0 | 0 | 97 | 36 | 61 | 63% | 3-4 | 4.09 | 1.24 |
| 2011-08-30 | Anthony Vasquez | L | 25 | W 6-13 | vs ANA | 2 | 2 | L | 4.0 | 7 | 8 | 7 | 2 | 3 | 1 | 90 | 38 | 52 | 58% | 1-1 | 12.00 | 2.33 |
| 2011-08-31 | Felix Hernandez | R | 25 | L 2-1 | vs ANA | 29 | 201 | W | 9.0 | 5 | 1 | 1 | 0 | 1 | 9 | 108 | 29 | 79 | 73% | 13-11 | 3.27 | 1.18 |
| 2011-09-01 | Charlie Furbush | L | 25 | W 3-4 | vs ANA | 8 | 8 | L | 6.0 | 4 | 4 | 4 | 2 | 3 | 5 | 99 | 39 | 60 | 61% | 3-7 | 5.00 | 1.52 |
| 2011-09-02 | Jason Vargas | L | 29 | L 2-9 | @ OAK | 28 | 94 | L | 5.0 | 6 | 5 | 4 | 0 | 4 | 4 | 117 | 49 | 68 | 58% | 7-13 | 4.60 | 1.37 |
| 2011-09-03 | Michael Pineda | R | 23 | L 0-3 | @ OAK | 26 | 26 | L | 6.0 | 5 | 3 | 3 | 1 | 2 | 7 | 105 | 35 | 70 | 67% | 9-9 | 3.74 | 1.09 |
| 2011-09-04 | Blake Beavan | R | 23 | L 5-8 | @ OAK | 11 | 11 | L | 5.0 | 7 | 4 | 4 | 0 | 3 | 3 | 100 | 41 | 59 | 59% | 3-5 | 4.31 | 1.30 |
| 2011-09-05 | Anthony Vasquez | L | 25 | L 3-7 | @ ANA | 3 | 3 | L | 5.2 | 5 | 7 | 3 | 2 | 2 | 3 | 99 | 38 | 61 | 62% | 1-2 | 9.00 | 1.87 |
| 2011-09-06 | Felix Hernandez | R | 25 | W 2-1 | @ ANA | 30 | 202 | W | 8.0 | 4 | 1 | 0 | 0 | 2 | 7 | 112 | 39 | 73 | 65% | 14-11 | 3.15 | 1.17 |
| 2011-09-07 | Charlie Furbush | L | 25 | L 1-3 | @ ANA | 9 | 9 | L | 7.1 | 5 | 3 | 3 | 0 | 1 | 3 | 103 | 38 | 65 | 63% | 3-8 | 4.82 | 1.44 |
| 2011-09-08 | Jason Vargas | L | 29 | L 4-1 | vs KCA | 29 | 95 | W | 6.0 | 4 | 1 | 1 | 0 | 2 | 3 | 102 | 38 | 64 | 63% | 8-13 | 4.50 | 1.36 |
| 2011-09-09 | Blake Beavan | R | 23 | L 7-3 | vs KCA | 12 | 12 | W | 6.1 | 9 | 3 | 3 | 1 | 0 | 3 | 93 | 24 | 69 | 74% | 4-5 | 4.32 | 1.31 |
| 2011-09-10 | Michael Pineda | R | 23 | W 2-4 | vs KCA | 27 | 27 | L | 8.0 | 5 | 3 | 3 | 1 | 1 | 8 | 101 | 29 | 72 | 71% | 9-10 | 3.72 | 1.08 |
| 2011-09-11 | Anthony Vasquez | L | 25 | W 1-2 | vs KCA | 4 | 4 | L | 6.0 | 7 | 2 | 2 | 0 | 0 | 2 | 86 | 22 | 64 | 74% | 1-3 | 7.29 | 1.67 |
| 2011-09-12 | Felix Hernandez | R | 25 | W 3-9 | vs NYA | 31 | 203 | L | 6.0 | 9 | 6 | 6 | 2 | 0 | 4 | 93 | 30 | 63 | 68% | 14-12 | 3.31 | 1.17 |
| 2011-09-13 | Charlie Furbush | L | 25 | W 2-3 | vs NYA | 10 | 10 | L | 5.1 | 7 | 3 | 3 | 1 | 0 | 6 | 89 | 36 | 53 | 60% | 3-9 | 4.86 | 1.43 |
| 2011-09-14 | Jason Vargas | L | 29 | L 2-1 | vs NYA | 30 | 96 | - | 6.2 | 3 | 1 | 1 | 1 | 1 | 6 | 99 | 29 | 70 | 71% | 8-13 | 4.38 | 1.33 |
| 2011-09-16 | Blake Beavan | R | 23 | L 4-0 | vs TEX | 13 | 13 | W | 8.0 | 4 | 0 | 0 | 0 | 0 | 3 | 95 | 31 | 64 | 67% | 5-5 | 3.92 | 1.24 |
| 2011-09-17 | Anthony Vasquez | L | 25 | W 6-7 | vs TEX | 5 | 5 | L | 3.0 | 7 | 5 | 5 | 3 | 1 | 3 | 63 | 23 | 40 | 63% | 1-4 | 8.25 | 1.79 |
| 2011-09-18 | Felix Hernandez | R | 25 | W 0-3 | vs TEX | 32 | 204 | L | 7.0 | 9 | 3 | 3 | 1 | 1 | 5 | 104 | 34 | 70 | 67% | 14-13 | 3.33 | 1.18 |
| 2011-09-19 | Charlie Furbush | L | 25 | W 12-6 | @ CLE | 11 | 11 | W | 5.0 | 10 | 6 | 6 | 2 | 1 | 8 | 98 | 36 | 62 | 63% | 4-9 | 5.22 | 1.48 |
| 2011-09-20 | Jason Vargas | L | 29 | W 5-4 | @ MIN | 31 | 97 | W | 6.0 | 9 | 4 | 3 | 0 | 2 | 4 | 114 | 41 | 73 | 64% | 9-13 | 4.38 | 1.34 |
| 2011-09-21 | Michael Pineda | R | 23 | W 5-4 | @ MIN | 28 | 28 | - | 4.0 | 6 | 2 | 2 | 0 | 2 | 2 | 85 | 33 | 52 | 61% | 9-10 | 3.74 | 1.10 |
| 2011-09-22 | Blake Beavan | R | 23 | L 2-3 | @ MIN | 14 | 14 | - | 7.0 | 6 | 2 | 2 | 0 | 0 | 4 | 93 | 28 | 65 | 70% | 5-5 | 3.82 | 1.21 |
| 2011-09-23 | Anthony Vasquez | L | 25 | L 3-5 | @ TEX | 6 | 6 | L | 3.1 | 7 | 5 | 5 | 3 | 2 | 1 | 77 | 34 | 43 | 56% | 1-5 | 9.00 | 1.93 |
| 2011-09-24 | Felix Hernandez | R | 25 | L 3-7 | @ TEX | 33 | 205 | L | 3.1 | 12 | 7 | 5 | 0 | 1 | 2 | 61 | 13 | 48 | 79% | 14-14 | 3.46 | 1.22 |
| 2011-09-25 | Charlie Furbush | L | 25 | L 5-12 | @ TEX | 12 | 12 | L | 4.1 | 6 | 5 | 5 | 2 | 1 | 4 | 98 | 33 | 65 | 66% | 4-10 | 5.51 | 1.49 |
| 2011-09-26 | Jason Vargas | L | 29 | L 4-2 | vs OAK | 32 | 98 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 10 | 104 | 26 | 78 | 75% | 10-13 | 4.25 | 1.31 |
| 2011-09-27 | Blake Beavan | R | 23 | W 0-7 | vs OAK | 15 | 15 | L | 5.0 | 8 | 7 | 7 | 2 | 2 | 4 | 84 | 28 | 56 | 67% | 5-6 | 4.27 | 1.25 |
| 2011-09-28 | Anthony Vasquez | L | 25 | W 0-2 | vs OAK | 7 | 7 | L | 2.0 | 4 | 2 | 2 | 1 | 0 | 1 | 43 | 17 | 26 | 60% | 1-6 | 9.00 | 1.93 |