| 2011-03-31 | @ LAN | 1 | L 1-2 | 0-1 | 3 | 56,000 | Tim Lincecum | Clayton Kershaw | Clayton Kershaw | Tim Lincecum | Jonathan Broxton | 1 | 2 | -1 |
| 2011-04-01 | @ LAN | 2 | L 3-4 | 0-2 | 5 | 44,834 | Jonathan Sanchez | Chad Billingsley | Chad Billingsley | Jonathan Sanchez | Jonathan Broxton | 4 | 6 | -2 |
| 2011-04-02 | @ LAN | 3 | W 10-0 | 1-2 | 5 | 40,809 | Matt Cain | Ted Lilly | Matt Cain | Ted Lilly | | 14 | 6 | 8 |
| 2011-04-03 | @ LAN | 4 | L 5-7 | 1-3 | 5 | 50,896 | Barry Zito | Hiroki Kuroda | Hiroki Kuroda | Dan Runzler | Jonathan Broxton | 19 | 13 | 6 |
| 2011-04-05 | @ SDN | 5 | L 1-3 | 1-4 | 5 | 43,146 | Madison Bumgarner | Aaron Harang | Aaron Harang | Madison Bumgarner | Heath Bell | 20 | 16 | 4 |
| 2011-04-06 | @ SDN | 6 | W 8-4 | 2-4 | 5 | 24,368 | Tim Lincecum | Tim Stauffer | Tim Lincecum | Tim Stauffer | Ramon Ramirez | 28 | 20 | 8 |
| 2011-04-08 | vs SLN | 7 | W 5-4 | 3-4 | 5 | 42,048 | Jonathan Sanchez | Jake Westbrook | Dan Runzler | Brian Tallet | | 33 | 24 | 9 |
| 2011-04-09 | vs SLN | 8 | W 3-2 | 4-4 | 3 | 41,742 | Matt Cain | Jaime Garcia | Ramon Ramirez | Ryan Franklin | | 36 | 26 | 10 |
| 2011-04-10 | vs SLN | 9 | L 1-6 | 4-5 | 5 | 42,092 | Barry Zito | Kyle Lohse | Kyle Lohse | Barry Zito | | 37 | 32 | 5 |
| 2011-04-11 | vs LAN | 10 | L 1-6 | 4-6 | 5 | 40,870 | Madison Bumgarner | Clayton Kershaw | Clayton Kershaw | Madison Bumgarner | | 38 | 38 | 0 |
| 2011-04-12 | vs LAN | 11 | W 5-4 | 5-6 | 4 | 41,960 | Tim Lincecum | Chad Billingsley | Jeremy Affeldt | Blake Hawksworth | Brian Wilson | 43 | 42 | 1 |
| 2011-04-13 | vs LAN | 12 | W 4-3 | 6-6 | 3 | 42,060 | Jonathan Sanchez | Ted Lilly | Jonathan Sanchez | Ted Lilly | Brian Wilson | 47 | 45 | 2 |
| 2011-04-15 | @ ARI | 13 | W 5-2 | 7-6 | 2 | 23,090 | Matt Cain | Daniel Hudson | Matt Cain | Daniel Hudson | Brian Wilson | 52 | 47 | 5 |
| 2011-04-16 | @ ARI | 14 | W 5-3 | 8-6 | 2 | 25,590 | Barry Zito | Joe Saunders | Guillermo Mota | Joe Saunders | Brian Wilson | 57 | 50 | 7 |
| 2011-04-17 | @ ARI | 15 | L 5-6 | 8-7 | 2 | 26,195 | Madison Bumgarner | Barry Enright | Josh Collmenter | Dan Runzler | | 62 | 56 | 6 |
| 2011-04-18 | @ COL | 16 | W 8-1 | 9-7 | 2 | 31,079 | Tim Lincecum | Esmil Rogers | Tim Lincecum | Esmil Rogers | | 70 | 57 | 13 |
| 2011-04-19 | @ COL | 17 | W 6-3 | 10-7 | 2 | 30,320 | Jonathan Sanchez | Ubaldo Jimenez | Jonathan Sanchez | Ubaldo Jimenez | Brian Wilson | 76 | 60 | 16 |
| 2011-04-20 | @ COL | 18 | L 2-10 | 10-8 | 2 | 27,758 | Matt Cain | Jorge de la Rosa | Jorge de la Rosa | Matt Cain | | 78 | 70 | 8 |
| 2011-04-22 | vs ATL | 19 | L 1-4 | 10-9 | 2 | 42,404 | Madison Bumgarner | Tommy Hanson | Tommy Hanson | Madison Bumgarner | Craig Kimbrel | 79 | 74 | 5 |
| 2011-04-23 | vs ATL | 20 | L 2-5 | 10-10 | 3 | 42,395 | Tim Lincecum | Tim Hudson | Tim Hudson | Tim Lincecum | Craig Kimbrel | 81 | 79 | 2 |
| 2011-04-24 | vs ATL | 21 | L 6-9 | 10-11 | 3 | 42,295 | Jonathan Sanchez | Brandon Beachy | Eric O'Flaherty | Brian Wilson | Jonny Venters | 87 | 88 | -1 |
| 2011-04-26 | @ PIT | 22 | W 3-2 | 11-11 | 2 | 9,832 | Matt Cain | Charlie Morton | Sergio Romo | Joel Hanrahan | Brian Wilson | 90 | 90 | 0 |
| 2011-04-27 | @ PIT | 23 | L 0-2 | 11-12 | 3 | 9,048 | Madison Bumgarner | James McDonald | James McDonald | Madison Bumgarner | Joel Hanrahan | 90 | 92 | -2 |
| 2011-04-28 | @ PIT | 24 | W 5-2 | 12-12 | 2 | 14,747 | Ryan Vogelsong | Jeff Karstens | Ryan Vogelsong | Jeff Karstens | Brian Wilson | 95 | 94 | 1 |
| 2011-04-29 | @ WAS | 25 | L 0-3 | 12-13 | 3 | 21,399 | Tim Lincecum | Jason Marquis | Jason Marquis | Tim Lincecum | | 95 | 97 | -2 |
| 2011-04-30 | @ WAS | 26 | W 2-1 | 13-13 | 3 | 28,766 | Jonathan Sanchez | John Lannan | Guillermo Mota | John Lannan | Brian Wilson | 97 | 98 | -1 |
| 2011-05-01 | @ WAS | 27 | L 2-5 | 13-14 | 3 | 21,611 | Matt Cain | Jordan Zimmermann | Jordan Zimmermann | Matt Cain | Drew Storen | 99 | 103 | -4 |
| 2011-05-02 | @ WAS | 28 | L 0-2 | 13-15 | 3 | 15,342 | Madison Bumgarner | Tom Gorzelanny | Tom Gorzelanny | Madison Bumgarner | Drew Storen | 99 | 105 | -6 |
| 2011-05-03 | @ NYN | 29 | W 7-6 | 14-15 | 3 | 32,288 | Ryan Vogelsong | R.A. Dickey | Javier Lopez | Taylor Buchholz | Brian Wilson | 106 | 111 | -5 |
| 2011-05-04 | @ NYN | 30 | W 2-0 | 15-15 | 2 | 29,333 | Tim Lincecum | Chris Capuano | Tim Lincecum | Chris Capuano | Brian Wilson | 108 | 111 | -3 |
| 2011-05-05 | @ NYN | 31 | L 2-5 | 15-16 | 2 | 23,433 | Jonathan Sanchez | Mike Pelfrey | Mike Pelfrey | Jonathan Sanchez | Francisco Rodriguez | 110 | 116 | -6 |
| 2011-05-06 | vs COL | 32 | W 4-3 | 16-16 | 2 | 41,982 | Matt Cain | Ubaldo Jimenez | Brian Wilson | Felipe Paulino | | 114 | 119 | -5 |
| 2011-05-07 | vs COL | 33 | W 3-2 | 17-16 | 2 | 41,611 | Madison Bumgarner | Clayton Mortensen | Brian Wilson | Felipe Paulino | | 117 | 121 | -4 |
| 2011-05-08 | vs COL | 34 | W 3-0 | 18-16 | 2 | 42,132 | Ryan Vogelsong | Jorge de la Rosa | Ryan Vogelsong | Jorge de la Rosa | Brian Wilson | 120 | 121 | -1 |
| 2011-05-10 | vs ARI | 35 | W 1-0 | 19-16 | 2 | 41,039 | Tim Lincecum | Ian Kennedy | Brian Wilson | David Hernandez | | 121 | 121 | 0 |
| 2011-05-11 | vs ARI | 36 | W 4-3 | 20-16 | 2 | 41,026 | Jonathan Sanchez | Armando Galarraga | Jonathan Sanchez | Armando Galarraga | Brian Wilson | 125 | 124 | 1 |
| 2011-05-12 | vs ARI | 37 | W 3-2 | 21-16 | 1 | 41,126 | Matt Cain | Daniel Hudson | Matt Cain | Daniel Hudson | Javier Lopez | 128 | 126 | 2 |
| 2011-05-13 | @ CHN | 38 | L 4-11 | 21-17 | 2 | 37,433 | Madison Bumgarner | Ryan Dempster | Ryan Dempster | Madison Bumgarner | | 132 | 137 | -5 |
| 2011-05-14 | @ CHN | 39 | W 3-0 | 22-17 | 1 | 39,706 | Ryan Vogelsong | Doug Davis | Ryan Vogelsong | Doug Davis | | 135 | 137 | -2 |
| 2011-05-16 | @ COL | 40 | L 4-7 | 22-18 | 1 | 33,228 | Tim Lincecum | Clayton Mortensen | Clayton Mortensen | Tim Lincecum | Huston Street | 139 | 144 | -5 |
| 2011-05-17 | @ COL | 41 | L 3-5 | 22-19 | 2 | 41,105 | Jonathan Sanchez | Ubaldo Jimenez | Matt Belisle | Jonathan Sanchez | Huston Street | 142 | 149 | -7 |
| 2011-05-18 | @ LAN | 42 | W 8-5 | 23-19 | 1 | 30,421 | Matt Cain | Clayton Kershaw | Brian Wilson | Lance Cormier | | 150 | 154 | -4 |
| 2011-05-19 | @ LAN | 43 | W 3-1 | 24-19 | 1 | 34,248 | Madison Bumgarner | Chad Billingsley | Madison Bumgarner | Chad Billingsley | Brian Wilson | 153 | 155 | -2 |
| 2011-05-20 | vs OAK | 44 | W 2-1 | 25-19 | 1 | 42,224 | Ryan Vogelsong | Trevor Cahill | Javier Lopez | Brian Fuentes | | 155 | 156 | -1 |
| 2011-05-21 | vs OAK | 45 | W 3-0 | 26-19 | 1 | 42,152 | Tim Lincecum | Brett Anderson | Tim Lincecum | Brett Anderson | | 158 | 156 | 2 |
| 2011-05-22 | vs OAK | 46 | W 5-4 | 27-19 | 1 | 42,288 | Jonathan Sanchez | Gio Gonzalez | Sergio Romo | Brian Fuentes | | 163 | 160 | 3 |
| 2011-05-24 | vs FLO | 47 | L 1-5 | 27-20 | 1 | 41,165 | Matt Cain | Ricky Nolasco | Ricky Nolasco | Matt Cain | Leo Nunez | 164 | 165 | -1 |
| 2011-05-25 | vs FLO | 48 | L 6-7 | 27-21 | 1 | 41,037 | Madison Bumgarner | Chris Volstad | Ryan Webb | Guillermo Mota | Burke Badenhop | 170 | 172 | -2 |
| 2011-05-26 | vs FLO | 49 | L 0-1 | 27-22 | 1 | 41,472 | Ryan Vogelsong | Anibal Sanchez | Anibal Sanchez | Ryan Vogelsong | | 170 | 173 | -3 |
| 2011-05-27 | @ MIL | 50 | W 5-4 | 28-22 | 1 | 37,034 | Tim Lincecum | Shaun Marcum | Tim Lincecum | Shaun Marcum | Brian Wilson | 175 | 177 | -2 |
| 2011-05-28 | @ MIL | 51 | L 2-3 | 28-23 | 1 | 42,512 | Jonathan Sanchez | Randy Wolf | John Axford | Guillermo Mota | | 177 | 180 | -3 |
| 2011-05-29 | @ MIL | 52 | L 0-6 | 28-24 | 2 | 43,035 | Matt Cain | Yovani Gallardo | Yovani Gallardo | Matt Cain | | 177 | 186 | -9 |
| 2011-05-30 | @ SLN | 53 | W 7-3 | 29-24 | 2 | 40,849 | Madison Bumgarner | Kyle McClellan | Madison Bumgarner | Kyle McClellan | | 184 | 189 | -5 |
| 2011-05-31 | @ SLN | 54 | L 3-4 | 29-25 | 2 | 37,748 | Ryan Vogelsong | Chris Carpenter | Ryan Franklin | Javier Lopez | Fernando Salas | 187 | 193 | -6 |
| 2011-06-01 | @ SLN | 55 | W 7-5 | 30-25 | 2 | 35,775 | Tim Lincecum | Jake Westbrook | Sergio Romo | Ryan Franklin | Brian Wilson | 194 | 198 | -4 |
| 2011-06-02 | @ SLN | 56 | W 12-7 | 31-25 | 1 | 34,104 | Jonathan Sanchez | Lance Lynn | Jonathan Sanchez | Lance Lynn | Jeremy Affeldt | 206 | 205 | 1 |
| 2011-06-03 | vs COL | 57 | W 3-1 | 32-25 | 1 | 41,021 | Matt Cain | Juan Nicasio | Matt Cain | Juan Nicasio | Brian Wilson | 209 | 206 | 3 |
| 2011-06-04 | vs COL | 58 | L 1-2 | 32-26 | 2 | 41,046 | Madison Bumgarner | Jhoulis Chacin | Jhoulis Chacin | Madison Bumgarner | Huston Street | 210 | 208 | 2 |
| 2011-06-05 | vs COL | 59 | W 2-1 | 33-26 | 1 | 41,369 | Ryan Vogelsong | Jason Hammel | Ryan Vogelsong | Matt Lindstrom | Brian Wilson | 212 | 209 | 3 |
| 2011-06-06 | vs WAS | 60 | W 5-4 | 34-26 | 1 | 41,180 | Tim Lincecum | John Lannan | Javier Lopez | Craig Stammen | | 217 | 213 | 4 |
| 2011-06-07 | vs WAS | 61 | L 1-2 | 34-27 | 1 | 41,786 | Jonathan Sanchez | Jordan Zimmermann | Jordan Zimmermann | Jonathan Sanchez | Drew Storen | 218 | 215 | 3 |
| 2011-06-08 | vs WAS | 62 | W 3-1 | 35-27 | 1 | 41,738 | Matt Cain | Yuniesky Maya | Matt Cain | Sean Burnett | | 221 | 216 | 5 |
| 2011-06-09 | vs CIN | 63 | L 0-3 | 35-28 | 1 | 41,106 | Madison Bumgarner | Johnny Cueto | Johnny Cueto | Madison Bumgarner | Francisco Cordero | 221 | 219 | 2 |
| 2011-06-10 | vs CIN | 64 | W 3-2 | 36-28 | 1 | 41,686 | Ryan Vogelsong | Travis Wood | Brian Wilson | Jose Arredondo | | 224 | 221 | 3 |
| 2011-06-11 | vs CIN | 65 | L 2-10 | 36-29 | 1 | 41,735 | Tim Lincecum | Mike Leake | Mike Leake | Tim Lincecum | | 226 | 231 | -5 |
| 2011-06-12 | vs CIN | 66 | W 4-2 | 37-29 | 1 | 42,084 | Jonathan Sanchez | Edinson Volquez | Ramon Ramirez | Jose Arredondo | Brian Wilson | 230 | 233 | -3 |
| 2011-06-14 | @ ARI | 67 | W 6-5 | 38-29 | 1 | 23,746 | Matt Cain | Josh Collmenter | Matt Cain | Josh Collmenter | Brian Wilson | 236 | 238 | -2 |
| 2011-06-15 | @ ARI | 68 | W 5-2 | 39-29 | 1 | 24,194 | Madison Bumgarner | Joe Saunders | Madison Bumgarner | Joe Saunders | Brian Wilson | 241 | 240 | 1 |
| 2011-06-16 | @ ARI | 69 | L 2-3 | 39-30 | 1 | 23,468 | Ryan Vogelsong | Ian Kennedy | David Hernandez | Santiago Casilla | | 243 | 243 | 0 |
| 2011-06-17 | @ OAK | 70 | L 2-5 | 39-31 | 1 | 36,067 | Tim Lincecum | Graham Godfrey | Graham Godfrey | Tim Lincecum | Andrew Bailey | 245 | 248 | -3 |
| 2011-06-18 | @ OAK | 71 | L 2-4 | 39-32 | 1 | 36,067 | Jonathan Sanchez | Guillermo Moscoso | Brad Ziegler | Jonathan Sanchez | Andrew Bailey | 247 | 252 | -5 |
| 2011-06-19 | @ OAK | 72 | L 1-2 | 39-33 | 1 | 36,067 | Matt Cain | Trevor Cahill | Trevor Cahill | Jeremy Affeldt | Brian Fuentes | 248 | 254 | -6 |
| 2011-06-21 | vs MIN | 73 | L 2-9 | 39-34 | 2 | 41,958 | Madison Bumgarner | Carl Pavano | Carl Pavano | Madison Bumgarner | | 250 | 263 | -13 |
| 2011-06-22 | vs MIN | 74 | W 5-1 | 40-34 | 2 | 41,886 | Ryan Vogelsong | Nick Blackburn | Ryan Vogelsong | Nick Blackburn | | 255 | 264 | -9 |
| 2011-06-23 | vs MIN | 75 | W 2-1 | 41-34 | 2 | 42,481 | Tim Lincecum | Brian Duensing | Tim Lincecum | Brian Duensing | Brian Wilson | 257 | 265 | -8 |
| 2011-06-24 | vs CLE | 76 | W 4-3 | 42-34 | 2 | 41,690 | Jonathan Sanchez | Carlos Carrasco | Santiago Casilla | Carlos Carrasco | Brian Wilson | 261 | 268 | -7 |
| 2011-06-25 | vs CLE | 77 | W 1-0 | 43-34 | 1 | 42,130 | Matt Cain | Justin Masterson | Matt Cain | Justin Masterson | Brian Wilson | 262 | 268 | -6 |
| 2011-06-26 | vs CLE | 78 | W 3-1 | 44-34 | 1 | 41,978 | Madison Bumgarner | Fausto Carmona | Madison Bumgarner | Fausto Carmona | Jeremy Affeldt | 265 | 269 | -4 |
| 2011-06-28 | @ CHN | 79 | W 13-7 | 45-34 | 2 | 39,157 | Ryan Vogelsong | Doug Davis | Ryan Vogelsong | Doug Davis | | 278 | 276 | 2 |
| 2011-06-28 | @ CHN | 80 | W 6-3 | 45-34 | 2 | 38,360 | Barry Zito | Rodrigo Lopez | Barry Zito | Rodrigo Lopez | Brian Wilson | 284 | 279 | 5 |
| 2011-06-29 | @ CHN | 81 | L 1-2 | 46-35 | 1 | 37,221 | Tim Lincecum | Ryan Dempster | Carlos Marmol | Sergio Romo | | 285 | 281 | 4 |
| 2011-06-30 | @ CHN | 82 | L 2-5 | 46-36 | 1 | 38,158 | Matt Cain | Carlos Zambrano | John Grabow | Ramon Ramirez | | 287 | 286 | 1 |
| 2011-07-01 | @ DET | 83 | W 4-3 | 47-36 | 1 | 35,583 | Madison Bumgarner | Brad Penny | Brian Wilson | Jose Valverde | Jeremy Affeldt | 291 | 289 | 2 |
| 2011-07-02 | @ DET | 84 | W 15-3 | 48-36 | 1 | 38,983 | Barry Zito | Max Scherzer | Barry Zito | Max Scherzer | Guillermo Mota | 306 | 292 | 14 |
| 2011-07-03 | @ DET | 85 | L 3-6 | 48-37 | 1 | 31,904 | Ryan Vogelsong | Rick Porcello | Rick Porcello | Jeremy Affeldt | Jose Valverde | 309 | 298 | 11 |
| 2011-07-04 | vs SDN | 86 | L 3-5 | 48-38 | 1 | 42,300 | Tim Lincecum | Clayton Richard | Clayton Richard | Tim Lincecum | Heath Bell | 312 | 303 | 9 |
| 2011-07-05 | vs SDN | 87 | L 3-5 | 48-39 | 1 | 41,403 | Matt Cain | Tim Stauffer | Tim Stauffer | Matt Cain | Heath Bell | 315 | 308 | 7 |
| 2011-07-06 | vs SDN | 88 | W 6-5 | 49-39 | 1 | 41,916 | Madison Bumgarner | Dustin Moseley | Javier Lopez | Pat Neshek | | 321 | 313 | 8 |
| 2011-07-07 | vs SDN | 89 | W 2-1 | 50-39 | 1 | 41,521 | Barry Zito | Cory Luebke | Barry Zito | Cory Luebke | Brian Wilson | 323 | 314 | 9 |
| 2011-07-08 | vs NYN | 90 | L 2-5 | 50-40 | 1 | 41,028 | Ryan Vogelsong | R.A. Dickey | Pedro Beato | Brian Wilson | Francisco Rodriguez | 325 | 319 | 6 |
| 2011-07-09 | vs NYN | 91 | W 3-1 | 51-40 | 1 | 42,117 | Tim Lincecum | Chris Capuano | Tim Lincecum | Chris Capuano | Sergio Romo | 328 | 320 | 8 |
| 2011-07-10 | vs NYN | 92 | W 4-2 | 52-40 | 1 | 42,123 | Matt Cain | Mike Pelfrey | Matt Cain | Mike Pelfrey | Brian Wilson | 332 | 322 | 10 |
| 2011-07-14 | @ SDN | 93 | W 6-2 | 53-40 | 1 | 32,292 | Madison Bumgarner | Aaron Harang | Santiago Casilla | Luke Gregerson | Brian Wilson | 338 | 324 | 14 |
| 2011-07-15 | @ SDN | 94 | W 6-1 | 54-40 | 1 | 42,055 | Tim Lincecum | Dustin Moseley | Tim Lincecum | Dustin Moseley | | 344 | 325 | 19 |
| 2011-07-16 | @ SDN | 95 | L 3-11 | 54-41 | 1 | 42,024 | Barry Zito | Cory Luebke | Cory Luebke | Barry Zito | | 347 | 336 | 11 |
| 2011-07-17 | @ SDN | 96 | W 4-3 | 55-41 | 1 | 36,351 | Matt Cain | Mat Latos | Javier Lopez | Chad Qualls | Brian Wilson | 351 | 339 | 12 |
| 2011-07-18 | vs LAN | 97 | W 5-0 | 56-41 | 1 | 42,323 | Ryan Vogelsong | Chad Billingsley | Ryan Vogelsong | Chad Billingsley | | 356 | 339 | 17 |
| 2011-07-19 | vs LAN | 98 | W 5-3 | 57-41 | 1 | 42,391 | Madison Bumgarner | Rubby de la Rosa | Madison Bumgarner | Hong-Chih Kuo | Brian Wilson | 361 | 342 | 19 |
| 2011-07-20 | vs LAN | 99 | L 0-1 | 57-42 | 1 | 42,487 | Tim Lincecum | Clayton Kershaw | Clayton Kershaw | Tim Lincecum | Javy Guerra | 361 | 343 | 18 |
| 2011-07-22 | vs MIL | 100 | L 2-4 | 57-43 | 1 | 42,297 | Matt Cain | Shaun Marcum | Shaun Marcum | Matt Cain | John Axford | 363 | 347 | 16 |
| 2011-07-23 | vs MIL | 101 | W 4-2 | 58-43 | 1 | 42,277 | Ryan Vogelsong | Randy Wolf | Ryan Vogelsong | Randy Wolf | Brian Wilson | 367 | 349 | 18 |
| 2011-07-24 | vs MIL | 102 | W 2-1 | 59-43 | 1 | 42,262 | Madison Bumgarner | Yovani Gallardo | Madison Bumgarner | Yovani Gallardo | Brian Wilson | 369 | 350 | 19 |
| 2011-07-26 | @ PHI | 103 | L 2-7 | 59-44 | 1 | 45,740 | Barry Zito | Vance Worley | Vance Worley | Barry Zito | | 371 | 357 | 14 |
| 2011-07-27 | @ PHI | 104 | W 2-1 | 60-44 | 1 | 45,800 | Matt Cain | Cole Hamels | Matt Cain | Cole Hamels | Brian Wilson | 373 | 358 | 15 |
| 2011-07-28 | @ PHI | 105 | W 4-1 | 61-44 | 1 | 45,646 | Tim Lincecum | Kyle Kendrick | Tim Lincecum | Kyle Kendrick | Brian Wilson | 377 | 359 | 18 |
| 2011-07-29 | @ CIN | 106 | L 3-4 | 61-45 | 1 | 29,016 | Ryan Vogelsong | Dontrelle Willis | Jose Arredondo | Brian Wilson | | 380 | 363 | 17 |
| 2011-07-30 | @ CIN | 107 | L 2-7 | 61-46 | 1 | 40,402 | Madison Bumgarner | Mike Leake | Mike Leake | Madison Bumgarner | | 382 | 370 | 12 |
| 2011-07-31 | @ CIN | 108 | L 0-9 | 61-47 | 1 | 37,864 | Barry Zito | Johnny Cueto | Johnny Cueto | Barry Zito | | 382 | 379 | 3 |
| 2011-08-01 | vs ARI | 109 | L 2-5 | 61-48 | 1 | 42,366 | Matt Cain | Ian Kennedy | Ian Kennedy | Matt Cain | J.J. Putz | 384 | 384 | 0 |
| 2011-08-02 | vs ARI | 110 | L 1-6 | 61-49 | 2 | 42,332 | Tim Lincecum | Daniel Hudson | Daniel Hudson | Tim Lincecum | | 385 | 390 | -5 |
| 2011-08-03 | vs ARI | 111 | W 8-1 | 62-49 | 1 | 42,477 | Ryan Vogelsong | Jason Marquis | Ryan Vogelsong | Jason Marquis | | 393 | 391 | 2 |
| 2011-08-04 | vs PHI | 112 | L 0-3 | 62-50 | 1 | 42,013 | Madison Bumgarner | Cliff Lee | Cliff Lee | Madison Bumgarner | | 393 | 394 | -1 |
| 2011-08-05 | vs PHI | 113 | L 2-9 | 62-51 | 1 | 42,165 | Jonathan Sanchez | Vance Worley | Vance Worley | Jonathan Sanchez | | 395 | 403 | -8 |
| 2011-08-06 | vs PHI | 114 | L 1-2 | 62-52 | 1 | 42,183 | Matt Cain | Cole Hamels | Cole Hamels | Matt Cain | | 396 | 405 | -9 |
| 2011-08-07 | vs PHI | 115 | W 3-1 | 63-52 | 1 | 42,366 | Tim Lincecum | Roy Oswalt | Tim Lincecum | Roy Oswalt | Brian Wilson | 399 | 406 | -7 |
| 2011-08-08 | vs PIT | 116 | L 0-5 | 63-53 | 1 | 42,405 | Ryan Vogelsong | Charlie Morton | Charlie Morton | Ryan Vogelsong | | 399 | 411 | -12 |
| 2011-08-09 | vs PIT | 117 | W 6-0 | 64-53 | 1 | 42,648 | Madison Bumgarner | James McDonald | Madison Bumgarner | James McDonald | | 405 | 411 | -6 |
| 2011-08-10 | vs PIT | 118 | L 2-9 | 64-54 | 2 | 42,603 | Jonathan Sanchez | Jeff Karstens | Jeff Karstens | Jonathan Sanchez | | 407 | 420 | -13 |
| 2011-08-12 | @ FLO | 119 | L 1-2 | 64-55 | 2 | 22,431 | Matt Cain | Ricky Nolasco | Ricky Nolasco | Matt Cain | Leo Nunez | 408 | 422 | -14 |
| 2011-08-13 | @ FLO | 120 | W 3-0 | 65-55 | 2 | 25,013 | Tim Lincecum | Javier Vazquez | Tim Lincecum | Javier Vazquez | Brian Wilson | 411 | 422 | -11 |
| 2011-08-14 | @ FLO | 121 | W 5-2 | 66-55 | 2 | 20,020 | Ryan Vogelsong | Chris Volstad | Ryan Vogelsong | Chris Volstad | Ramon Ramirez | 416 | 424 | -8 |
| 2011-08-15 | @ ATL | 122 | L 4-5 | 66-56 | 2 | 23,498 | Madison Bumgarner | Tim Hudson | Cristhian Martinez | Brian Wilson | | 420 | 429 | -9 |
| 2011-08-16 | @ ATL | 123 | L 1-2 | 66-57 | 2 | 22,108 | Jonathan Sanchez | Randall Delgado | Arodys Vizcaino | Javier Lopez | | 421 | 431 | -10 |
| 2011-08-17 | @ ATL | 124 | W 7-5 | 67-57 | 2 | 22,202 | Matt Cain | Jair Jurrjens | Matt Cain | Jair Jurrjens | | 428 | 436 | -8 |
| 2011-08-18 | @ ATL | 125 | L 0-1 | 67-58 | 2 | 30,720 | Tim Lincecum | Mike Minor | Mike Minor | Tim Lincecum | Craig Kimbrel | 428 | 437 | -9 |
| 2011-08-19 | @ HOU | 126 | L 0-6 | 67-59 | 2 | 26,259 | Ryan Vogelsong | Wandy Rodriguez | Wandy Rodriguez | Ryan Vogelsong | | 428 | 443 | -15 |
| 2011-08-20 | @ HOU | 127 | L 5-7 | 67-60 | 2 | 29,046 | Madison Bumgarner | Jordan Lyles | Jordan Lyles | Madison Bumgarner | Mark Melancon | 433 | 450 | -17 |
| 2011-08-21 | @ HOU | 128 | W 6-4 | 68-60 | 2 | 25,838 | Dan Runzler | Henry Sosa | Jeremy Affeldt | Mark Melancon | Ramon Ramirez | 439 | 454 | -15 |
| 2011-08-23 | vs SDN | 129 | L 5-7 | 68-61 | 2 | 41,288 | Matt Cain | Mat Latos | Erik Hamren | Ramon Ramirez | Heath Bell | 444 | 461 | -17 |
| 2011-08-24 | vs SDN | 130 | W 2-1 | 69-61 | 2 | 41,542 | Tim Lincecum | Tim Stauffer | Tim Lincecum | Tim Stauffer | Santiago Casilla | 446 | 462 | -16 |
| 2011-08-25 | vs HOU | 131 | L 1-3 | 69-62 | 2 | 41,115 | Ryan Vogelsong | Henry Sosa | Henry Sosa | Ryan Vogelsong | Mark Melancon | 447 | 465 | -18 |
| 2011-08-26 | vs HOU | 132 | W 2-1 | 70-62 | 2 | 41,438 | Madison Bumgarner | J.A. Happ | Madison Bumgarner | J.A. Happ | Santiago Casilla | 449 | 466 | -17 |
| 2011-08-27 | vs HOU | 133 | W 2-1 | 71-62 | 2 | 42,318 | Eric Surkamp | Brett Myers | Jeremy Affeldt | Fernando Rodriguez | | 451 | 467 | -16 |
| 2011-08-28 | vs HOU | 134 | L 3-4 | 71-63 | 2 | 41,681 | Matt Cain | Bud Norris | Mark Melancon | Ramon Ramirez | David Carpenter | 454 | 471 | -17 |
| 2011-08-29 | vs CHN | 135 | L 0-7 | 71-64 | 2 | 41,063 | Tim Lincecum | Randy Wells | Randy Wells | Tim Lincecum | | 454 | 478 | -24 |
| 2011-08-30 | vs CHN | 136 | L 2-5 | 71-65 | 2 | 41,165 | Ryan Vogelsong | Matt Garza | Matt Garza | Ryan Vogelsong | Carlos Marmol | 456 | 483 | -27 |
| 2011-08-31 | vs CHN | 137 | W 4-0 | 72-65 | 2 | 41,099 | Madison Bumgarner | Rodrigo Lopez | Madison Bumgarner | Rodrigo Lopez | | 460 | 483 | -23 |
| 2011-09-02 | vs ARI | 138 | W 6-2 | 73-65 | 2 | 40,948 | Matt Cain | Joe Saunders | Matt Cain | Joe Saunders | | 466 | 485 | -19 |
| 2011-09-03 | vs ARI | 139 | L 2-7 | 73-66 | 2 | 41,951 | Tim Lincecum | Ian Kennedy | Ian Kennedy | Tim Lincecum | | 468 | 492 | -24 |
| 2011-09-04 | vs ARI | 140 | L 1-4 | 73-67 | 2 | 42,222 | Ryan Vogelsong | Daniel Hudson | Daniel Hudson | Ryan Vogelsong | J.J. Putz | 469 | 496 | -27 |
| 2011-09-05 | @ SDN | 141 | W 7-2 | 74-67 | 2 | 25,066 | Madison Bumgarner | Tim Stauffer | Madison Bumgarner | Tim Stauffer | | 476 | 498 | -22 |
| 2011-09-06 | @ SDN | 142 | W 6-4 | 75-67 | 2 | 21,866 | Eric Surkamp | Wade LeBlanc | Eric Surkamp | Wade LeBlanc | Ramon Ramirez | 482 | 502 | -20 |
| 2011-09-07 | @ SDN | 143 | L 1-3 | 75-68 | 2 | 18,173 | Matt Cain | Aaron Harang | Aaron Harang | Matt Cain | Heath Bell | 483 | 505 | -22 |
| 2011-09-09 | vs LAN | 144 | L 1-2 | 75-69 | 2 | 41,902 | Tim Lincecum | Clayton Kershaw | Clayton Kershaw | Santiago Casilla | Javy Guerra | 484 | 507 | -23 |
| 2011-09-10 | vs LAN | 145 | L 0-3 | 75-70 | 2 | 42,121 | Ryan Vogelsong | Dana Eveland | Dana Eveland | Ryan Vogelsong | Javy Guerra | 484 | 510 | -26 |
| 2011-09-11 | vs LAN | 146 | W 8-1 | 76-70 | 2 | 41,466 | Madison Bumgarner | Hiroki Kuroda | Madison Bumgarner | Hiroki Kuroda | | 492 | 511 | -19 |
| 2011-09-12 | vs SDN | 147 | W 8-3 | 77-70 | 2 | 41,069 | Eric Surkamp | Aaron Harang | Eric Surkamp | Aaron Harang | | 500 | 514 | -14 |
| 2011-09-13 | vs SDN | 148 | W 3-2 | 78-70 | 2 | 41,510 | Matt Cain | Cory Luebke | Ramon Ramirez | Brad Brach | | 503 | 516 | -13 |
| 2011-09-14 | vs SDN | 149 | W 3-1 | 79-70 | 2 | 41,209 | Tim Lincecum | Mat Latos | Tim Lincecum | Mat Latos | Santiago Casilla | 506 | 517 | -11 |
| 2011-09-15 | @ COL | 150 | W 8-5 | 80-70 | 2 | 34,364 | Ryan Vogelsong | Jhoulis Chacin | Ryan Vogelsong | Jhoulis Chacin | Santiago Casilla | 514 | 522 | -8 |
| 2011-09-16 | @ COL | 151 | W 9-1 | 81-70 | 2 | 47,302 | Madison Bumgarner | Alex White | Madison Bumgarner | Alex White | | 523 | 523 | 0 |
| 2011-09-17 | @ COL | 152 | W 6-5 | 82-70 | 2 | 38,961 | Eric Surkamp | Drew Pomeranz | Waldis Joaquin | Huston Street | Santiago Casilla | 529 | 528 | 1 |
| 2011-09-18 | @ COL | 153 | W 12-5 | 83-70 | 2 | 31,875 | Matt Cain | Esmil Rogers | Matt Cain | Esmil Rogers | | 541 | 533 | 8 |
| 2011-09-20 | @ LAN | 154 | L 1-2 | 83-71 | 2 | 32,526 | Tim Lincecum | Clayton Kershaw | Clayton Kershaw | Tim Lincecum | Javy Guerra | 542 | 535 | 7 |
| 2011-09-21 | @ LAN | 155 | W 8-5 | 84-71 | 2 | 32,334 | Ryan Vogelsong | Dana Eveland | Ryan Vogelsong | Dana Eveland | Brian Wilson | 550 | 540 | 10 |
| 2011-09-22 | @ LAN | 156 | L 2-8 | 84-72 | 2 | 37,560 | Madison Bumgarner | Hiroki Kuroda | Hiroki Kuroda | Madison Bumgarner | | 552 | 548 | 4 |
| 2011-09-23 | @ ARI | 157 | L 1-3 | 84-73 | 2 | 42,606 | Matt Cain | Joe Saunders | David Hernandez | Matt Cain | J.J. Putz | 553 | 551 | 2 |
| 2011-09-24 | @ ARI | 158 | L 2-15 | 84-74 | 2 | 49,076 | Eric Surkamp | Ian Kennedy | Ian Kennedy | Eric Surkamp | | 555 | 566 | -11 |
| 2011-09-25 | @ ARI | 159 | L 2-5 | 84-75 | 2 | 41,243 | Tim Lincecum | Josh Collmenter | Josh Collmenter | Tim Lincecum | J.J. Putz | 557 | 571 | -14 |
| 2011-09-26 | vs COL | 160 | W 3-1 | 85-75 | 2 | 41,956 | Ryan Vogelsong | Jhoulis Chacin | Ryan Vogelsong | Jhoulis Chacin | Santiago Casilla | 560 | 572 | -12 |
| 2011-09-27 | vs COL | 161 | W 7-0 | 86-75 | 2 | 42,370 | Madison Bumgarner | Alex White | Madison Bumgarner | Alex White | | 567 | 572 | -5 |
| 2011-09-28 | vs COL | 162 | L 3-6 | 86-76 | 2 | 41,873 | Eric Surkamp | Drew Pomeranz | Drew Pomeranz | Eric Surkamp | Rafael Betancourt | 570 | 578 | -8 |