| 2011-03-31 | @ SLN | 1 | W 5-3 | 1-0 | 2 | 46,368 | Tim Stauffer | Chris Carpenter | Pat Neshek | Bryan Augenstein | Heath Bell | 5 | 3 | 2 |
| 2011-04-02 | @ SLN | 2 | W 11-3 | 2-0 | 1 | 38,527 | Clayton Richard | Jake Westbrook | Clayton Richard | Jake Westbrook | | 16 | 6 | 10 |
| 2011-04-03 | @ SLN | 3 | L 0-2 | 2-1 | 2 | 36,414 | Dustin Moseley | Jaime Garcia | Jaime Garcia | Dustin Moseley | | 16 | 8 | 8 |
| 2011-04-05 | vs SFN | 4 | W 3-1 | 3-1 | 1 | 43,146 | Aaron Harang | Madison Bumgarner | Aaron Harang | Madison Bumgarner | Heath Bell | 19 | 9 | 10 |
| 2011-04-06 | vs SFN | 5 | L 4-8 | 3-2 | 2 | 24,368 | Tim Stauffer | Tim Lincecum | Tim Lincecum | Tim Stauffer | Ramon Ramirez | 23 | 17 | 6 |
| 2011-04-08 | vs LAN | 6 | L 2-4 | 3-3 | 4 | 32,585 | Clayton Richard | Ted Lilly | Blake Hawksworth | Ernesto Frieri | Jonathan Broxton | 25 | 21 | 4 |
| 2011-04-09 | vs LAN | 7 | L 0-4 | 3-4 | 5 | 42,420 | Dustin Moseley | Hiroki Kuroda | Hiroki Kuroda | Dustin Moseley | Jonathan Broxton | 25 | 25 | 0 |
| 2011-04-10 | vs LAN | 8 | W 7-2 | 4-4 | 4 | 33,949 | Aaron Harang | John Ely | Aaron Harang | John Ely | | 32 | 27 | 5 |
| 2011-04-11 | vs CIN | 9 | L 2-3 | 4-5 | 4 | 18,022 | Mat Latos | Edinson Volquez | Edinson Volquez | Mat Latos | Francisco Cordero | 34 | 30 | 4 |
| 2011-04-12 | vs CIN | 10 | L 2-8 | 4-6 | 5 | 17,379 | Clayton Richard | Sam LeCure | Logan Ondrusek | Cory Luebke | | 36 | 38 | -2 |
| 2011-04-13 | vs CIN | 11 | W 3-2 | 5-6 | 5 | 17,057 | Tim Stauffer | Travis Wood | Heath Bell | Nick Masset | | 39 | 40 | -1 |
| 2011-04-14 | @ HOU | 12 | L 0-1 | 5-7 | 6 | 20,045 | Dustin Moseley | Bud Norris | Bud Norris | Dustin Moseley | Brandon Lyon | 39 | 41 | -2 |
| 2011-04-15 | @ HOU | 13 | W 4-2 | 6-7 | 3 | 23,755 | Aaron Harang | J.A. Happ | Aaron Harang | J.A. Happ | Heath Bell | 43 | 43 | 0 |
| 2011-04-16 | @ HOU | 14 | L 3-5 | 6-8 | 3 | 28,100 | Mat Latos | Nelson Figueroa | Mark Melancon | Mat Latos | Brandon Lyon | 46 | 48 | -2 |
| 2011-04-17 | @ HOU | 15 | W 8-6 | 7-8 | 3 | 22,899 | Clayton Richard | Brett Myers | Ernesto Frieri | Mark Melancon | Heath Bell | 54 | 54 | 0 |
| 2011-04-18 | @ CHN | 16 | L 0-1 | 7-9 | 4 | 36,597 | Tim Stauffer | Carlos Zambrano | Carlos Marmol | Chad Qualls | | 54 | 55 | -1 |
| 2011-04-20 | @ CHN | 17 | L 1-2 | 7-10 | 6 | 35,544 | Dustin Moseley | Matt Garza | Jeff Samardzija | Luke Gregerson | | 55 | 57 | -2 |
| 2011-04-20 | @ CHN | 18 | W 5-4 | 7-10 | 6 | 35,095 | Aaron Harang | James Russell | Aaron Harang | James Russell | Heath Bell | 60 | 61 | -1 |
| 2011-04-21 | vs PHI | 19 | L 0-3 | 8-11 | 5 | 27,056 | Mat Latos | Roy Oswalt | Roy Oswalt | Mat Latos | Jose Contreras | 60 | 64 | -4 |
| 2011-04-22 | vs PHI | 20 | L 0-2 | 8-12 | 5 | 33,572 | Clayton Richard | Cole Hamels | Cole Hamels | Clayton Richard | Ryan Madson | 60 | 66 | -6 |
| 2011-04-23 | vs PHI | 21 | L 2-4 | 8-13 | 5 | 40,038 | Tim Stauffer | Joe Blanton | Kyle Kendrick | Chad Qualls | Ryan Madson | 62 | 70 | -8 |
| 2011-04-24 | vs PHI | 22 | L 1-3 | 8-14 | 5 | 24,031 | Wade LeBlanc | Roy Halladay | Roy Halladay | Wade LeBlanc | Antonio Bastardo | 63 | 73 | -10 |
| 2011-04-25 | vs ATL | 23 | W 5-3 | 9-14 | 5 | 18,288 | Dustin Moseley | Derek Lowe | Cory Luebke | Cristhian Martinez | | 68 | 76 | -8 |
| 2011-04-26 | vs ATL | 24 | L 2-8 | 9-15 | 5 | 20,492 | Aaron Harang | Jair Jurrjens | Jair Jurrjens | Aaron Harang | | 70 | 84 | -14 |
| 2011-04-27 | vs ATL | 25 | L 0-7 | 9-16 | 5 | 20,026 | Mat Latos | Tommy Hanson | Tommy Hanson | Mat Latos | | 70 | 91 | -21 |
| 2011-04-29 | @ LAN | 26 | L 2-3 | 9-17 | 5 | 36,870 | Clayton Richard | Ted Lilly | Ted Lilly | Clayton Richard | Jonathan Broxton | 72 | 94 | -22 |
| 2011-04-30 | @ LAN | 27 | W 5-2 | 10-17 | 5 | 34,453 | Tim Stauffer | Hiroki Kuroda | Luke Gregerson | Matt Guerrier | Heath Bell | 77 | 96 | -19 |
| 2011-05-01 | @ LAN | 28 | W 7-0 | 11-17 | 5 | 39,869 | Dustin Moseley | Jon Garland | Dustin Moseley | Jon Garland | | 84 | 96 | -12 |
| 2011-05-02 | vs PIT | 29 | L 3-4 | 11-18 | 5 | 20,546 | Aaron Harang | James McDonald | James McDonald | Aaron Harang | Joel Hanrahan | 87 | 100 | -13 |
| 2011-05-03 | vs PIT | 30 | W 6-5 | 12-18 | 5 | 18,636 | Mat Latos | Jeff Karstens | Mike Adams | Joe Beimel | Heath Bell | 93 | 105 | -12 |
| 2011-05-04 | vs PIT | 31 | L 4-7 | 12-19 | 5 | 16,613 | Clayton Richard | Kevin Correia | Kevin Correia | Clayton Richard | | 97 | 112 | -15 |
| 2011-05-06 | vs ARI | 32 | W 4-3 | 13-19 | 5 | 30,878 | Tim Stauffer | Armando Galarraga | Chad Qualls | Sam Demel | | 101 | 115 | -14 |
| 2011-05-07 | vs ARI | 33 | L 0-6 | 13-20 | 5 | 35,936 | Dustin Moseley | Daniel Hudson | Daniel Hudson | Dustin Moseley | | 101 | 121 | -20 |
| 2011-05-08 | vs ARI | 34 | W 4-3 | 14-20 | 5 | 21,490 | Aaron Harang | Joe Saunders | Aaron Harang | Joe Saunders | Heath Bell | 105 | 124 | -19 |
| 2011-05-09 | @ MIL | 35 | L 3-4 | 14-21 | 5 | 27,058 | Mat Latos | Zack Greinke | Zack Greinke | Mat Latos | John Axford | 108 | 128 | -20 |
| 2011-05-10 | @ MIL | 36 | L 6-8 | 14-22 | 5 | 22,861 | Clayton Richard | Shaun Marcum | Shaun Marcum | Clayton Richard | John Axford | 114 | 136 | -22 |
| 2011-05-11 | @ MIL | 37 | W 13-6 | 15-22 | 5 | 25,652 | Tim Stauffer | Randy Wolf | Chad Qualls | Kameron Loe | | 127 | 142 | -15 |
| 2011-05-13 | @ COL | 38 | L 7-12 | 15-23 | 5 | 40,278 | Dustin Moseley | Jorge de la Rosa | Jorge de la Rosa | Dustin Moseley | | 134 | 154 | -20 |
| 2011-05-14 | @ COL | 39 | W 9-7 | 16-23 | 5 | 34,252 | Aaron Harang | Jhoulis Chacin | Mike Adams | Huston Street | Heath Bell | 143 | 161 | -18 |
| 2011-05-15 | @ COL | 40 | W 8-2 | 17-23 | 5 | 38,109 | Mat Latos | Jason Hammel | Mat Latos | Jason Hammel | | 151 | 163 | -12 |
| 2011-05-16 | @ ARI | 41 | W 8-4 | 18-23 | 4 | 17,958 | Clayton Richard | Armando Galarraga | Clayton Richard | Armando Galarraga | Mike Adams | 159 | 167 | -8 |
| 2011-05-17 | @ ARI | 42 | L 1-6 | 18-24 | 5 | 16,365 | Tim Stauffer | Daniel Hudson | Daniel Hudson | Tim Stauffer | | 160 | 173 | -13 |
| 2011-05-18 | vs MIL | 43 | L 2-5 | 18-25 | 5 | 16,901 | Dustin Moseley | Yovani Gallardo | Yovani Gallardo | Dustin Moseley | John Axford | 162 | 178 | -16 |
| 2011-05-19 | vs MIL | 44 | W 1-0 | 19-25 | 5 | 16,286 | Aaron Harang | Chris Narveson | Heath Bell | Marco Estrada | | 163 | 178 | -15 |
| 2011-05-20 | vs SEA | 45 | L 1-4 | 19-26 | 5 | 26,501 | Mat Latos | Erik Bedard | Erik Bedard | Mat Latos | | 164 | 182 | -18 |
| 2011-05-21 | vs SEA | 46 | L 0-4 | 19-27 | 5 | 34,648 | Clayton Richard | Michael Pineda | Michael Pineda | Clayton Richard | | 164 | 186 | -22 |
| 2011-05-22 | vs SEA | 47 | L 1-6 | 19-28 | 5 | 34,705 | Tim Stauffer | Felix Hernandez | Felix Hernandez | Tim Stauffer | | 165 | 192 | -27 |
| 2011-05-23 | vs SLN | 48 | L 1-3 | 19-29 | 5 | 16,513 | Dustin Moseley | Kyle Lohse | Kyle Lohse | Heath Bell | Fernando Salas | 166 | 195 | -29 |
| 2011-05-24 | vs SLN | 49 | L 2-3 | 19-30 | 7 | 19,426 | Aaron Harang | Kyle McClellan | Miguel Batista | Ernesto Frieri | Eduardo Sanchez | 168 | 198 | -30 |
| 2011-05-25 | vs SLN | 50 | W 3-1 | 20-30 | 5 | 23,088 | Mat Latos | Chris Carpenter | Mat Latos | Chris Carpenter | Heath Bell | 171 | 199 | -28 |
| 2011-05-27 | @ WAS | 51 | L 1-2 | 20-31 | 5 | 21,024 | Clayton Richard | John Lannan | Drew Storen | Mike Adams | | 172 | 201 | -29 |
| 2011-05-28 | @ WAS | 52 | W 2-1 | 21-31 | 5 | 19,159 | Tim Stauffer | Jordan Zimmermann | Tim Stauffer | Jordan Zimmermann | Heath Bell | 174 | 202 | -28 |
| 2011-05-29 | @ WAS | 53 | W 5-4 | 22-31 | 5 | 23,169 | Dustin Moseley | Yuniesky Maya | Luke Gregerson | Drew Storen | Heath Bell | 179 | 206 | -27 |
| 2011-05-30 | @ ATL | 54 | W 3-2 | 23-31 | 5 | 25,832 | Aaron Harang | Tim Hudson | Chad Qualls | George Sherrill | Heath Bell | 182 | 208 | -26 |
| 2011-05-31 | @ ATL | 55 | W 5-4 | 24-31 | 5 | 18,782 | Mat Latos | Mike Minor | Mat Latos | Mike Minor | Heath Bell | 187 | 212 | -25 |
| 2011-06-01 | @ ATL | 56 | L 3-4 | 24-32 | 5 | 21,452 | Clayton Richard | Tommy Hanson | Tommy Hanson | Clayton Richard | Craig Kimbrel | 190 | 216 | -26 |
| 2011-06-02 | vs HOU | 57 | L 4-7 | 24-33 | 5 | 16,635 | Tim Stauffer | Bud Norris | Bud Norris | Tim Stauffer | Mark Melancon | 194 | 223 | -29 |
| 2011-06-03 | vs HOU | 58 | W 3-1 | 25-33 | 5 | 20,056 | Dustin Moseley | J.A. Happ | Dustin Moseley | J.A. Happ | Heath Bell | 197 | 224 | -27 |
| 2011-06-04 | vs HOU | 59 | W 6-3 | 26-33 | 5 | 28,208 | Aaron Harang | Aneury Rodriguez | Aaron Harang | Aneury Rodriguez | Heath Bell | 203 | 227 | -24 |
| 2011-06-05 | vs HOU | 60 | W 7-2 | 27-33 | 5 | 21,958 | Mat Latos | Jordan Lyles | Mat Latos | Jordan Lyles | | 210 | 229 | -19 |
| 2011-06-06 | vs COL | 61 | L 0-3 | 27-34 | 5 | 16,838 | Clayton Richard | Clayton Mortensen | Clayton Mortensen | Clayton Richard | Huston Street | 210 | 232 | -22 |
| 2011-06-07 | vs COL | 62 | W 2-0 | 28-34 | 5 | 17,732 | Tim Stauffer | Ubaldo Jimenez | Tim Stauffer | Ubaldo Jimenez | Heath Bell | 212 | 232 | -20 |
| 2011-06-08 | vs COL | 63 | L 3-5 | 28-35 | 5 | 17,220 | Dustin Moseley | Aaron Cook | Matt Lindstrom | Heath Bell | Huston Street | 215 | 237 | -22 |
| 2011-06-09 | vs WAS | 64 | W 7-3 | 29-35 | 5 | 16,464 | Aaron Harang | Livan Hernandez | Aaron Harang | Livan Hernandez | | 222 | 240 | -18 |
| 2011-06-10 | vs WAS | 65 | L 1-2 | 29-36 | 5 | 23,211 | Mat Latos | Jason Marquis | Jason Marquis | Mat Latos | Drew Storen | 223 | 242 | -19 |
| 2011-06-11 | vs WAS | 66 | L 1-2 | 29-37 | 5 | 25,027 | Clayton Richard | John Lannan | John Lannan | Clayton Richard | Drew Storen | 224 | 244 | -20 |
| 2011-06-12 | vs WAS | 67 | L 0-2 | 29-38 | 5 | 20,185 | Tim Stauffer | Jordan Zimmermann | Todd Coffey | Heath Bell | Drew Storen | 224 | 246 | -22 |
| 2011-06-13 | @ COL | 68 | W 3-1 | 30-38 | 5 | 32,395 | Anthony Bass | Aaron Cook | Anthony Bass | Aaron Cook | Heath Bell | 227 | 247 | -20 |
| 2011-06-14 | @ COL | 69 | L 3-6 | 30-39 | 5 | 35,045 | Wade LeBlanc | Juan Nicasio | Juan Nicasio | Wade LeBlanc | | 230 | 253 | -23 |
| 2011-06-15 | @ COL | 70 | L 3-6 | 30-40 | 5 | 35,877 | Mat Latos | Jhoulis Chacin | Jhoulis Chacin | Mat Latos | | 233 | 259 | -26 |
| 2011-06-17 | @ MIN | 71 | L 5-6 | 30-41 | 5 | 39,205 | Clayton Richard | Brian Duensing | Brian Duensing | Clayton Richard | Matt Capps | 238 | 265 | -27 |
| 2011-06-18 | @ MIN | 72 | L 0-1 | 30-42 | 5 | 40,225 | Tim Stauffer | Scott Baker | Scott Baker | Tim Stauffer | Matt Capps | 238 | 266 | -28 |
| 2011-06-19 | @ MIN | 73 | L 4-5 | 30-43 | 5 | 40,655 | Dustin Moseley | Francisco Liriano | Alex Burnett | Chad Qualls | | 242 | 271 | -29 |
| 2011-06-20 | @ BOS | 74 | L 5-14 | 30-44 | 5 | 38,020 | Wade LeBlanc | Andrew Miller | Matt Albers | Cory Luebke | | 247 | 285 | -38 |
| 2011-06-21 | @ BOS | 75 | W 5-4 | 31-44 | 5 | 38,422 | Mat Latos | Alfredo Aceves | Chad Qualls | Dan Wheeler | Heath Bell | 252 | 289 | -37 |
| 2011-06-22 | @ BOS | 76 | W 5-1 | 32-44 | 5 | 37,419 | Clayton Richard | John Lackey | Clayton Richard | John Lackey | | 257 | 290 | -33 |
| 2011-06-24 | vs ATL | 77 | W 11-2 | 33-44 | 5 | 27,227 | Tim Stauffer | Derek Lowe | Tim Stauffer | Derek Lowe | | 268 | 292 | -24 |
| 2011-06-25 | vs ATL | 78 | L 1-10 | 33-45 | 5 | 38,060 | Dustin Moseley | Jair Jurrjens | Jair Jurrjens | Dustin Moseley | | 269 | 302 | -33 |
| 2011-06-26 | vs ATL | 79 | W 4-1 | 34-45 | 5 | 24,048 | Cory Luebke | Tim Hudson | Mike Adams | Jonny Venters | Heath Bell | 273 | 303 | -30 |
| 2011-06-27 | vs KCA | 80 | W 4-3 | 35-45 | 5 | 23,635 | Mat Latos | Jeff Francis | Mat Latos | Jeff Francis | Heath Bell | 277 | 306 | -29 |
| 2011-06-28 | vs KCA | 81 | W 4-2 | 36-45 | 6 | 20,250 | Clayton Richard | Felipe Paulino | Clayton Richard | Felipe Paulino | Heath Bell | 281 | 308 | -27 |
| 2011-06-29 | vs KCA | 82 | W 4-1 | 37-45 | 4 | 24,461 | Tim Stauffer | Bruce Chen | Tim Stauffer | Bruce Chen | Heath Bell | 285 | 309 | -24 |
| 2011-07-01 | @ SEA | 83 | L 0-6 | 37-46 | 5 | 23,616 | Dustin Moseley | Jason Vargas | Jason Vargas | Dustin Moseley | | 285 | 315 | -30 |
| 2011-07-02 | @ SEA | 84 | W 1-0 | 38-46 | 4 | 22,798 | Cory Luebke | Doug Fister | Cory Luebke | Doug Fister | Heath Bell | 286 | 315 | -29 |
| 2011-07-03 | @ SEA | 85 | L 1-3 | 38-47 | 4 | 28,001 | Mat Latos | Blake Beavan | Blake Beavan | Mat Latos | Brandon League | 287 | 318 | -31 |
| 2011-07-04 | @ SFN | 86 | W 5-3 | 39-47 | 4 | 42,300 | Clayton Richard | Tim Lincecum | Clayton Richard | Tim Lincecum | Heath Bell | 292 | 321 | -29 |
| 2011-07-05 | @ SFN | 87 | W 5-3 | 40-47 | 4 | 41,403 | Tim Stauffer | Matt Cain | Tim Stauffer | Matt Cain | Heath Bell | 297 | 324 | -27 |
| 2011-07-06 | @ SFN | 88 | L 5-6 | 40-48 | 4 | 41,916 | Dustin Moseley | Madison Bumgarner | Javier Lopez | Pat Neshek | | 302 | 330 | -28 |
| 2011-07-07 | @ SFN | 89 | L 1-2 | 40-49 | 4 | 41,521 | Cory Luebke | Barry Zito | Barry Zito | Cory Luebke | Brian Wilson | 303 | 332 | -29 |
| 2011-07-08 | @ LAN | 90 | L 0-1 | 40-50 | 4 | 38,529 | Mat Latos | Chad Billingsley | Chad Billingsley | Mat Latos | Javy Guerra | 303 | 333 | -30 |
| 2011-07-09 | @ LAN | 91 | L 0-1 | 40-51 | 5 | 29,744 | Aaron Harang | Rubby de la Rosa | Blake Hawksworth | Luke Gregerson | | 303 | 334 | -31 |
| 2011-07-10 | @ LAN | 92 | L 1-4 | 40-52 | 5 | 35,249 | Tim Stauffer | Ted Lilly | Ted Lilly | Tim Stauffer | Javy Guerra | 304 | 338 | -34 |
| 2011-07-14 | vs SFN | 93 | L 2-6 | 40-53 | 5 | 32,292 | Aaron Harang | Madison Bumgarner | Santiago Casilla | Luke Gregerson | Brian Wilson | 306 | 344 | -38 |
| 2011-07-15 | vs SFN | 94 | L 1-6 | 40-54 | 5 | 42,055 | Dustin Moseley | Tim Lincecum | Tim Lincecum | Dustin Moseley | | 307 | 350 | -43 |
| 2011-07-16 | vs SFN | 95 | W 11-3 | 41-54 | 5 | 42,024 | Cory Luebke | Barry Zito | Cory Luebke | Barry Zito | | 318 | 353 | -35 |
| 2011-07-17 | vs SFN | 96 | L 3-4 | 41-55 | 5 | 36,351 | Mat Latos | Matt Cain | Javier Lopez | Chad Qualls | Brian Wilson | 321 | 357 | -36 |
| 2011-07-19 | @ FLO | 97 | W 4-0 | 42-55 | 5 | 17,101 | Tim Stauffer | Anibal Sanchez | Tim Stauffer | Anibal Sanchez | Heath Bell | 325 | 357 | -32 |
| 2011-07-20 | @ FLO | 98 | W 14-3 | 43-55 | 5 | 19,142 | Aaron Harang | Ricky Nolasco | Aaron Harang | Ricky Nolasco | | 339 | 360 | -21 |
| 2011-07-21 | @ FLO | 99 | W 5-3 | 44-55 | 4 | 27,143 | Dustin Moseley | Javier Vazquez | Dustin Moseley | Javier Vazquez | Heath Bell | 344 | 363 | -19 |
| 2011-07-22 | @ PHI | 100 | L 1-3 | 44-56 | 4 | 45,383 | Cory Luebke | Cole Hamels | Cole Hamels | Cory Luebke | Ryan Madson | 345 | 366 | -21 |
| 2011-07-23 | @ PHI | 101 | L 6-8 | 44-57 | 5 | 45,072 | Mat Latos | Kyle Kendrick | Michael Stutes | Chad Qualls | Ryan Madson | 351 | 374 | -23 |
| 2011-07-24 | @ PHI | 102 | L 3-5 | 44-58 | 5 | 45,241 | Tim Stauffer | Roy Halladay | Roy Halladay | Tim Stauffer | Antonio Bastardo | 354 | 379 | -25 |
| 2011-07-25 | @ PHI | 103 | W 5-4 | 45-58 | 5 | 45,640 | Aaron Harang | Cliff Lee | Aaron Harang | Cliff Lee | Heath Bell | 359 | 383 | -24 |
| 2011-07-26 | vs ARI | 104 | L 1-6 | 45-59 | 5 | 22,679 | Dustin Moseley | Joe Saunders | Joe Saunders | Dustin Moseley | | 360 | 389 | -29 |
| 2011-07-27 | vs ARI | 105 | L 3-4 | 45-60 | 5 | 28,377 | Cory Luebke | Ian Kennedy | Ian Kennedy | Cory Luebke | J.J. Putz | 363 | 393 | -30 |
| 2011-07-28 | vs ARI | 106 | W 4-3 | 46-60 | 5 | 23,348 | Mat Latos | Daniel Hudson | Luke Gregerson | Daniel Hudson | Heath Bell | 367 | 396 | -29 |
| 2011-07-29 | vs COL | 107 | L 2-3 | 46-61 | 5 | 27,612 | Tim Stauffer | Jason Hammel | Jason Hammel | Tim Stauffer | Huston Street | 369 | 399 | -30 |
| 2011-07-30 | vs COL | 108 | L 6-10 | 46-62 | 5 | 37,034 | Aaron Harang | Ubaldo Jimenez | Esmil Rogers | Aaron Harang | | 375 | 409 | -34 |
| 2011-07-31 | vs COL | 109 | W 8-3 | 47-62 | 5 | 22,516 | Wade LeBlanc | Juan Nicasio | Chad Qualls | Rex Brothers | | 383 | 412 | -29 |
| 2011-08-01 | vs LAN | 110 | L 2-6 | 47-63 | 5 | 22,417 | Cory Luebke | Clayton Kershaw | Clayton Kershaw | Cory Luebke | | 385 | 418 | -33 |
| 2011-08-02 | vs LAN | 111 | L 0-1 | 47-64 | 5 | 22,543 | Mat Latos | Hiroki Kuroda | Hiroki Kuroda | Mat Latos | Javy Guerra | 385 | 419 | -34 |
| 2011-08-03 | vs LAN | 112 | W 3-0 | 48-64 | 5 | 25,371 | Tim Stauffer | Ted Lilly | Tim Stauffer | Ted Lilly | Heath Bell | 388 | 419 | -31 |
| 2011-08-05 | @ PIT | 113 | W 15-5 | 49-64 | 5 | 37,766 | Aaron Harang | Jeff Karstens | Aaron Harang | Jeff Karstens | | 403 | 424 | -21 |
| 2011-08-06 | @ PIT | 114 | W 13-2 | 50-64 | 5 | 39,251 | Cory Luebke | Paul Maholm | Cory Luebke | Paul Maholm | | 416 | 426 | -10 |
| 2011-08-07 | @ PIT | 115 | W 7-3 | 51-64 | 5 | 35,601 | Mat Latos | Kevin Correia | Mat Latos | Kevin Correia | | 423 | 429 | -6 |
| 2011-08-08 | @ NYN | 116 | L 8-9 | 51-65 | 5 | 21,814 | Tim Stauffer | Mike Pelfrey | Jason Isringhausen | Heath Bell | | 431 | 438 | -7 |
| 2011-08-09 | @ NYN | 117 | L 4-5 | 51-66 | 5 | 24,619 | Wade LeBlanc | Chris Capuano | D.J. Carrasco | Chad Qualls | Jason Isringhausen | 435 | 443 | -8 |
| 2011-08-10 | @ NYN | 118 | W 9-5 | 52-66 | 5 | 39,589 | Aaron Harang | R.A. Dickey | Aaron Harang | R.A. Dickey | | 444 | 448 | -4 |
| 2011-08-11 | @ NYN | 119 | W 3-2 | 53-66 | 5 | 32,348 | Cory Luebke | Jonathon Niese | Chad Qualls | Jonathon Niese | Heath Bell | 447 | 450 | -3 |
| 2011-08-12 | @ CIN | 120 | L 3-5 | 53-67 | 5 | 28,346 | Mat Latos | Bronson Arroyo | Bill Bray | Josh Spence | Francisco Cordero | 450 | 455 | -5 |
| 2011-08-13 | @ CIN | 121 | L 1-13 | 53-68 | 5 | 31,374 | Tim Stauffer | Homer Bailey | Homer Bailey | Tim Stauffer | | 451 | 468 | -17 |
| 2011-08-14 | @ CIN | 122 | W 7-3 | 54-68 | 5 | 35,286 | Wade LeBlanc | Dontrelle Willis | Wade LeBlanc | Dontrelle Willis | | 458 | 471 | -13 |
| 2011-08-15 | vs NYN | 123 | L 4-5 | 54-69 | 5 | 30,094 | Aaron Harang | R.A. Dickey | Manny Acosta | Josh Spence | Jason Isringhausen | 462 | 476 | -14 |
| 2011-08-16 | vs NYN | 124 | W 6-1 | 55-69 | 5 | 24,212 | Cory Luebke | Jonathon Niese | Cory Luebke | Jonathon Niese | | 468 | 477 | -9 |
| 2011-08-17 | vs NYN | 125 | L 3-7 | 55-70 | 5 | 22,089 | Mat Latos | Dillon Gee | Dillon Gee | Mat Latos | | 471 | 484 | -13 |
| 2011-08-18 | vs FLO | 126 | W 3-1 | 56-70 | 5 | 18,403 | Tim Stauffer | Javier Vazquez | Tim Stauffer | Javier Vazquez | Heath Bell | 474 | 485 | -11 |
| 2011-08-19 | vs FLO | 127 | W 4-3 | 57-70 | 5 | 26,065 | Wade LeBlanc | Chris Volstad | Wade LeBlanc | Chris Volstad | Heath Bell | 478 | 488 | -10 |
| 2011-08-20 | vs FLO | 128 | W 14-1 | 58-70 | 5 | 37,268 | Aaron Harang | Clay Hensley | Aaron Harang | Clay Hensley | | 492 | 489 | 3 |
| 2011-08-21 | vs FLO | 129 | W 4-3 | 59-70 | 4 | 40,065 | Cory Luebke | Anibal Sanchez | Heath Bell | Edward Mujica | | 496 | 492 | 4 |
| 2011-08-23 | @ SFN | 130 | W 7-5 | 60-70 | 4 | 41,288 | Mat Latos | Matt Cain | Erik Hamren | Ramon Ramirez | Heath Bell | 503 | 497 | 6 |
| 2011-08-24 | @ SFN | 131 | L 1-2 | 60-71 | 5 | 41,542 | Tim Stauffer | Tim Lincecum | Tim Lincecum | Tim Stauffer | Santiago Casilla | 504 | 499 | 5 |
| 2011-08-26 | @ ARI | 132 | L 0-5 | 60-72 | 5 | 34,074 | Wade LeBlanc | Josh Collmenter | Josh Collmenter | Wade LeBlanc | | 504 | 504 | 0 |
| 2011-08-27 | @ ARI | 133 | L 1-3 | 60-73 | 5 | 35,603 | Aaron Harang | Joe Saunders | Joe Saunders | Aaron Harang | J.J. Putz | 505 | 507 | -2 |
| 2011-08-28 | @ ARI | 134 | L 1-6 | 60-74 | 5 | 27,564 | Cory Luebke | Ian Kennedy | Ian Kennedy | Cory Luebke | | 506 | 513 | -7 |
| 2011-08-29 | @ LAN | 135 | L 1-4 | 60-75 | 5 | 29,764 | Mat Latos | Clayton Kershaw | Clayton Kershaw | Mat Latos | | 507 | 517 | -10 |
| 2011-08-30 | @ LAN | 136 | L 5-8 | 60-76 | 5 | 36,589 | Tim Stauffer | Hiroki Kuroda | Hiroki Kuroda | Tim Stauffer | Javy Guerra | 512 | 525 | -13 |
| 2011-08-31 | @ LAN | 137 | L 2-4 | 60-77 | 5 | 27,767 | Wade LeBlanc | Ted Lilly | Ted Lilly | Wade LeBlanc | Javy Guerra | 514 | 529 | -15 |
| 2011-09-02 | vs COL | 138 | L 0-3 | 60-78 | 5 | 22,070 | Aaron Harang | Kevin Millwood | Kevin Millwood | Aaron Harang | Rafael Betancourt | 514 | 532 | -18 |
| 2011-09-03 | vs COL | 139 | L 4-5 | 60-79 | 5 | 23,974 | Cory Luebke | Alex White | Alex White | Cory Luebke | Rafael Betancourt | 518 | 537 | -19 |
| 2011-09-04 | vs COL | 140 | W 7-2 | 61-79 | 5 | 24,661 | Mat Latos | Aaron Cook | Mat Latos | Aaron Cook | | 525 | 539 | -14 |
| 2011-09-05 | vs SFN | 141 | L 2-7 | 61-80 | 5 | 25,066 | Tim Stauffer | Madison Bumgarner | Madison Bumgarner | Tim Stauffer | | 527 | 546 | -19 |
| 2011-09-06 | vs SFN | 142 | L 4-6 | 61-81 | 5 | 21,866 | Wade LeBlanc | Eric Surkamp | Eric Surkamp | Wade LeBlanc | Ramon Ramirez | 531 | 552 | -21 |
| 2011-09-07 | vs SFN | 143 | W 3-1 | 62-81 | 5 | 18,173 | Aaron Harang | Matt Cain | Aaron Harang | Matt Cain | Heath Bell | 534 | 553 | -19 |
| 2011-09-08 | @ ARI | 144 | L 1-4 | 62-82 | 5 | 21,402 | Cory Luebke | Ian Kennedy | Ian Kennedy | Cory Luebke | J.J. Putz | 535 | 557 | -22 |
| 2011-09-09 | @ ARI | 145 | L 2-3 | 62-83 | 5 | 29,639 | Mat Latos | Daniel Hudson | Daniel Hudson | Chad Qualls | | 537 | 560 | -23 |
| 2011-09-10 | @ ARI | 146 | L 5-6 | 62-84 | 5 | 48,017 | Tim Stauffer | Wade Miley | David Hernandez | Brad Brach | | 542 | 566 | -24 |
| 2011-09-11 | @ ARI | 147 | W 7-6 | 63-84 | 5 | 39,369 | Wade LeBlanc | Josh Collmenter | Wade LeBlanc | Josh Collmenter | Heath Bell | 549 | 572 | -23 |
| 2011-09-12 | @ SFN | 148 | L 3-8 | 63-85 | 5 | 41,069 | Aaron Harang | Eric Surkamp | Eric Surkamp | Aaron Harang | | 552 | 580 | -28 |
| 2011-09-13 | @ SFN | 149 | L 2-3 | 63-86 | 5 | 41,510 | Cory Luebke | Matt Cain | Ramon Ramirez | Brad Brach | | 554 | 583 | -29 |
| 2011-09-14 | @ SFN | 150 | L 1-3 | 63-87 | 5 | 41,209 | Mat Latos | Tim Lincecum | Tim Lincecum | Mat Latos | Santiago Casilla | 555 | 586 | -31 |
| 2011-09-16 | vs ARI | 151 | W 2-0 | 64-87 | 5 | 28,605 | Tim Stauffer | Wade Miley | Tim Stauffer | Wade Miley | Heath Bell | 557 | 586 | -29 |
| 2011-09-17 | vs ARI | 152 | W 3-1 | 65-87 | 5 | 36,242 | Wade LeBlanc | Josh Collmenter | Wade LeBlanc | Josh Collmenter | Heath Bell | 560 | 587 | -27 |
| 2011-09-18 | vs ARI | 153 | L 1-5 | 65-88 | 5 | 30,781 | Aaron Harang | Joe Saunders | Joe Saunders | Aaron Harang | J.J. Putz | 561 | 592 | -31 |
| 2011-09-19 | @ COL | 154 | W 8-2 | 66-88 | 5 | 27,450 | Cory Luebke | Kevin Millwood | Cory Luebke | Kevin Millwood | | 569 | 594 | -25 |
| 2011-09-20 | @ COL | 155 | W 2-1 | 67-88 | 5 | 32,465 | Mat Latos | Jhoulis Chacin | Mat Latos | Jhoulis Chacin | Heath Bell | 571 | 595 | -24 |
| 2011-09-21 | @ COL | 156 | W 4-0 | 68-88 | 5 | 31,457 | Anthony Bass | Aaron Cook | Anthony Bass | Aaron Cook | Heath Bell | 575 | 595 | -20 |
| 2011-09-23 | vs LAN | 157 | L 0-2 | 68-89 | 5 | 32,658 | Wade LeBlanc | Ted Lilly | Ted Lilly | Wade LeBlanc | Javy Guerra | 575 | 597 | -22 |
| 2011-09-24 | vs LAN | 158 | W 3-0 | 69-89 | 5 | 39,966 | Aaron Harang | Chad Billingsley | Aaron Harang | Chad Billingsley | Heath Bell | 578 | 597 | -19 |
| 2011-09-25 | vs LAN | 159 | L 2-6 | 69-90 | 5 | 32,387 | Cory Luebke | Clayton Kershaw | Clayton Kershaw | Cory Luebke | | 580 | 603 | -23 |
| 2011-09-26 | vs CHN | 160 | W 2-0 | 70-90 | 5 | 26,433 | Mat Latos | Casey Coleman | Mat Latos | Casey Coleman | Heath Bell | 582 | 603 | -21 |
| 2011-09-27 | vs CHN | 161 | L 2-6 | 70-91 | 5 | 39,058 | Anthony Bass | Matt Garza | Matt Garza | Chad Qualls | | 584 | 609 | -25 |
| 2011-09-28 | vs CHN | 162 | W 9-2 | 71-91 | 5 | 32,452 | Wade LeBlanc | Ryan Dempster | Wade LeBlanc | Ryan Dempster | | 593 | 611 | -18 |