| 2011-04-01 | vs SEA | 1 | L 2-6 | 0-1 | 4 | 36,067 | Trevor Cahill | Felix Hernandez | Felix Hernandez | Craig Breslow | | 2 | 6 | -4 |
| 2011-04-02 | vs SEA | 2 | L 2-5 | 0-2 | 4 | 15,088 | Brett Anderson | Jason Vargas | Chris Ray | Brian Fuentes | Brandon League | 4 | 11 | -7 |
| 2011-04-03 | vs SEA | 3 | W 7-1 | 1-2 | 3 | 22,292 | Gio Gonzalez | Doug Fister | Gio Gonzalez | Doug Fister | | 11 | 12 | -1 |
| 2011-04-05 | @ TOR | 4 | L 6-7 | 1-3 | 4 | 11,077 | Brandon McCarthy | Jo-Jo Reyes | Jason Frasor | Grant Balfour | | 17 | 19 | -2 |
| 2011-04-06 | @ TOR | 5 | L 3-5 | 1-4 | 4 | 11,684 | Dallas Braden | Jesse Litsch | Jesse Litsch | Dallas Braden | Jon Rauch | 20 | 24 | -4 |
| 2011-04-07 | @ TOR | 6 | W 2-1 | 2-4 | 3 | 19,528 | Trevor Cahill | Ricky Romero | Trevor Cahill | Jason Frasor | Brian Fuentes | 22 | 25 | -3 |
| 2011-04-08 | @ MIN | 7 | L 1-2 | 2-5 | 3 | 40,714 | Brett Anderson | Carl Pavano | Carl Pavano | Brett Anderson | Joe Nathan | 23 | 27 | -4 |
| 2011-04-09 | @ MIN | 8 | W 1-0 | 3-5 | 4 | 39,936 | Gio Gonzalez | Nick Blackburn | Gio Gonzalez | Nick Blackburn | Brian Fuentes | 24 | 27 | -3 |
| 2011-04-10 | @ MIN | 9 | W 5-3 | 4-5 | 3 | 38,484 | Brandon McCarthy | Scott Baker | Brandon McCarthy | Scott Baker | Brian Fuentes | 29 | 30 | -1 |
| 2011-04-11 | @ CHA | 10 | W 2-1 | 5-5 | 3 | 20,057 | Dallas Braden | Mark Buehrle | Tyson Ross | Jesse Crain | Brian Fuentes | 31 | 31 | 0 |
| 2011-04-12 | @ CHA | 11 | L 5-6 | 5-6 | 3 | 18,020 | Trevor Cahill | Edwin Jackson | Chris Sale | Bobby Cramer | | 36 | 37 | -1 |
| 2011-04-13 | @ CHA | 12 | W 7-4 | 6-6 | 3 | 16,523 | Brett Anderson | John Danks | Grant Balfour | Matt Thornton | Brian Fuentes | 43 | 41 | 2 |
| 2011-04-14 | vs DET | 13 | L 0-3 | 6-7 | 3 | 11,129 | Gio Gonzalez | Phil Coke | Phil Coke | Tyson Ross | Jose Valverde | 43 | 44 | -1 |
| 2011-04-15 | vs DET | 14 | L 4-8 | 6-8 | 3 | 21,853 | Brandon McCarthy | Rick Porcello | Brayan Villarreal | Brian Fuentes | | 47 | 52 | -5 |
| 2011-04-16 | vs DET | 15 | W 6-2 | 7-8 | 3 | 16,265 | Dallas Braden | Justin Verlander | Dallas Braden | Justin Verlander | | 53 | 54 | -1 |
| 2011-04-17 | vs DET | 16 | W 5-1 | 8-8 | 3 | 16,460 | Trevor Cahill | Brad Penny | Trevor Cahill | Brad Penny | | 58 | 55 | 3 |
| 2011-04-19 | vs BOS | 17 | W 5-0 | 9-8 | 3 | 25,230 | Brett Anderson | John Lackey | Brett Anderson | John Lackey | | 63 | 55 | 8 |
| 2011-04-20 | vs BOS | 18 | L 3-5 | 9-9 | 3 | 29,045 | Gio Gonzalez | Clay Buchholz | Clay Buchholz | Gio Gonzalez | Jonathan Papelbon | 66 | 60 | 6 |
| 2011-04-21 | @ SEA | 19 | L 0-1 | 9-10 | 3 | 12,770 | Brandon McCarthy | Felix Hernandez | Felix Hernandez | Brandon McCarthy | Brandon League | 66 | 61 | 5 |
| 2011-04-22 | @ SEA | 20 | L 0-4 | 9-11 | 3 | 17,798 | Tyson Ross | Michael Pineda | Michael Pineda | Tyson Ross | Brandon League | 66 | 65 | 1 |
| 2011-04-23 | @ SEA | 21 | W 9-1 | 10-11 | 3 | 25,355 | Trevor Cahill | Jason Vargas | Trevor Cahill | Jason Vargas | | 75 | 66 | 9 |
| 2011-04-24 | @ SEA | 22 | W 5-2 | 11-11 | 3 | 16,530 | Brett Anderson | Doug Fister | Brett Anderson | Aaron Laffey | Brian Fuentes | 80 | 68 | 12 |
| 2011-04-25 | @ ANA | 23 | L 0-5 | 11-12 | 3 | 37,115 | Gio Gonzalez | Jered Weaver | Jered Weaver | Gio Gonzalez | | 80 | 73 | 7 |
| 2011-04-26 | @ ANA | 24 | L 3-8 | 11-13 | 3 | 37,228 | Brandon McCarthy | Tyler Chatwood | Tyler Chatwood | Brandon McCarthy | | 83 | 81 | 2 |
| 2011-04-27 | @ ANA | 25 | W 2-1 | 12-13 | 3 | 37,247 | Tyson Ross | Dan Haren | Brian Fuentes | Jordan Walden | Brad Ziegler | 85 | 82 | 3 |
| 2011-04-29 | vs TEX | 26 | W 3-1 | 13-13 | 3 | 17,226 | Trevor Cahill | C.J. Wilson | Trevor Cahill | C.J. Wilson | Brian Fuentes | 88 | 83 | 5 |
| 2011-04-30 | vs TEX | 27 | L 2-11 | 13-14 | 3 | 27,285 | Brett Anderson | Colby Lewis | Colby Lewis | Brett Anderson | | 90 | 94 | -4 |
| 2011-05-01 | vs TEX | 28 | W 7-2 | 14-14 | 3 | 15,178 | Gio Gonzalez | Matt Harrison | Gio Gonzalez | Matt Harrison | | 97 | 96 | 1 |
| 2011-05-02 | vs TEX | 29 | W 5-4 | 15-14 | 3 | 9,193 | Brandon McCarthy | Derek Holland | Grant Balfour | Darren Oliver | | 102 | 100 | 2 |
| 2011-05-03 | vs CLE | 30 | L 1-4 | 15-15 | 3 | 10,135 | Tyson Ross | Fausto Carmona | Fausto Carmona | Brian Fuentes | Chris Perez | 103 | 104 | -1 |
| 2011-05-04 | vs CLE | 31 | W 3-1 | 16-15 | 3 | 13,872 | Trevor Cahill | Josh Tomlin | Trevor Cahill | Josh Tomlin | Grant Balfour | 106 | 105 | 1 |
| 2011-05-05 | vs CLE | 32 | L 3-4 | 16-16 | 3 | 14,353 | Brett Anderson | Jeanmar Gomez | Chad Durbin | Craig Breslow | Chris Perez | 109 | 109 | 0 |
| 2011-05-06 | @ KCA | 33 | W 3-2 | 17-16 | 2 | 30,690 | Gio Gonzalez | Sean O'Sullivan | Gio Gonzalez | Sean O'Sullivan | Brian Fuentes | 112 | 111 | 1 |
| 2011-05-07 | @ KCA | 34 | L 3-4 | 17-17 | 3 | 25,828 | Brandon McCarthy | Luke Hochevar | Joakim Soria | Brandon McCarthy | | 115 | 115 | 0 |
| 2011-05-08 | @ KCA | 35 | W 5-2 | 18-17 | 2 | 22,435 | Tyson Ross | Jeff Francis | Tyson Ross | Jeff Francis | Brian Fuentes | 120 | 117 | 3 |
| 2011-05-09 | @ TEX | 36 | W 7-2 | 19-17 | 2 | 24,375 | Trevor Cahill | C.J. Wilson | Trevor Cahill | C.J. Wilson | | 127 | 119 | 8 |
| 2011-05-10 | @ TEX | 37 | L 2-7 | 19-18 | 2 | 31,655 | Brett Anderson | Colby Lewis | Colby Lewis | Brett Anderson | | 129 | 126 | 3 |
| 2011-05-13 | vs CHA | 38 | L 3-4 | 19-19 | 3 | 12,690 | Brandon McCarthy | Philip Humber | Philip Humber | Brandon McCarthy | Sergio Santos | 132 | 130 | 2 |
| 2011-05-14 | vs CHA | 39 | W 6-2 | 20-19 | 2 | 17,291 | Tyson Ross | Gavin Floyd | Tyson Ross | Gavin Floyd | | 138 | 132 | 6 |
| 2011-05-15 | vs CHA | 40 | L 3-4 | 20-20 | 3 | 19,018 | Trevor Cahill | Mark Buehrle | Mark Buehrle | Trevor Cahill | Sergio Santos | 141 | 136 | 5 |
| 2011-05-16 | vs ANA | 41 | W 5-4 | 21-20 | 3 | 11,061 | Brett Anderson | Joel Pineiro | Grant Balfour | Fernando Rodney | | 146 | 140 | 6 |
| 2011-05-17 | vs ANA | 42 | W 14-0 | 22-20 | 1 | 12,190 | Gio Gonzalez | Tyler Chatwood | Gio Gonzalez | Tyler Chatwood | | 160 | 140 | 20 |
| 2011-05-18 | vs MIN | 43 | L 3-4 | 22-21 | 2 | 15,355 | Brandon McCarthy | Carl Pavano | Joe Nathan | Brian Fuentes | Matt Capps | 163 | 144 | 19 |
| 2011-05-19 | vs MIN | 44 | L 1-11 | 22-22 | 2 | 22,320 | Tyson Ross | Nick Blackburn | Nick Blackburn | Tyson Ross | | 164 | 155 | 9 |
| 2011-05-20 | @ SFN | 45 | L 1-2 | 22-23 | 3 | 42,224 | Trevor Cahill | Ryan Vogelsong | Javier Lopez | Brian Fuentes | | 165 | 157 | 8 |
| 2011-05-21 | @ SFN | 46 | L 0-3 | 22-24 | 3 | 42,152 | Brett Anderson | Tim Lincecum | Tim Lincecum | Brett Anderson | | 165 | 160 | 5 |
| 2011-05-22 | @ SFN | 47 | L 4-5 | 22-25 | 4 | 42,288 | Gio Gonzalez | Jonathan Sanchez | Sergio Romo | Brian Fuentes | | 169 | 165 | 4 |
| 2011-05-23 | @ ANA | 48 | L 1-4 | 22-26 | 4 | 36,215 | Josh Outman | Jered Weaver | Scott Downs | Brian Fuentes | Jordan Walden | 170 | 169 | 1 |
| 2011-05-24 | @ ANA | 49 | W 6-1 | 23-26 | 4 | 39,117 | Guillermo Moscoso | Dan Haren | Guillermo Moscoso | Dan Haren | | 176 | 170 | 6 |
| 2011-05-25 | @ ANA | 50 | L 1-4 | 23-27 | 4 | 40,253 | Trevor Cahill | Ervin Santana | Ervin Santana | Trevor Cahill | Jordan Walden | 177 | 174 | 3 |
| 2011-05-26 | @ ANA | 51 | W 4-3 | 24-27 | 4 | 33,412 | Brett Anderson | Joel Pineiro | Brett Anderson | Joel Pineiro | | 181 | 177 | 4 |
| 2011-05-27 | vs BAL | 52 | W 6-2 | 25-27 | 4 | 12,110 | Gio Gonzalez | Chris Tillman | Brad Ziegler | Alfredo Simon | | 187 | 179 | 8 |
| 2011-05-28 | vs BAL | 53 | W 4-2 | 26-27 | 4 | 23,795 | Josh Outman | Brad Bergesen | Josh Outman | Brad Bergesen | Brian Fuentes | 191 | 181 | 10 |
| 2011-05-29 | vs BAL | 54 | W 6-4 | 27-27 | 3 | 15,373 | Guillermo Moscoso | Zachary Britton | Guillermo Moscoso | Zachary Britton | Brian Fuentes | 197 | 185 | 12 |
| 2011-05-30 | vs NYA | 55 | L 0-5 | 27-28 | 4 | 35,067 | Trevor Cahill | Bartolo Colon | Bartolo Colon | Trevor Cahill | | 197 | 190 | 7 |
| 2011-05-31 | vs NYA | 56 | L 3-10 | 27-29 | 4 | 22,581 | Brett Anderson | Freddy Garcia | Freddy Garcia | Brett Anderson | | 200 | 200 | 0 |
| 2011-06-01 | vs NYA | 57 | L 2-4 | 27-30 | 4 | 25,469 | Gio Gonzalez | A.J. Burnett | A.J. Burnett | Gio Gonzalez | Mariano Rivera | 202 | 204 | -2 |
| 2011-06-03 | @ BOS | 58 | L 6-8 | 27-31 | 4 | 37,808 | Josh Outman | Clay Buchholz | Bobby Jenks | Joey Devine | Jonathan Papelbon | 208 | 212 | -4 |
| 2011-06-04 | @ BOS | 59 | L 8-9 | 27-32 | 4 | 37,485 | Trevor Cahill | Josh Beckett | Alfredo Aceves | Guillermo Moscoso | | 216 | 221 | -5 |
| 2011-06-05 | @ BOS | 60 | L 3-6 | 27-33 | 4 | 37,796 | Brett Anderson | John Lackey | John Lackey | Brett Anderson | Daniel Bard | 219 | 227 | -8 |
| 2011-06-06 | @ BAL | 61 | L 2-4 | 27-34 | 4 | 10,556 | Gio Gonzalez | Brian Matusz | Brian Matusz | Gio Gonzalez | Kevin Gregg | 221 | 231 | -10 |
| 2011-06-07 | @ BAL | 62 | L 0-4 | 27-35 | 4 | 13,652 | Guillermo Moscoso | Chris Jakubauskas | Chris Jakubauskas | Guillermo Moscoso | | 221 | 235 | -14 |
| 2011-06-08 | @ BAL | 63 | L 2-3 | 27-36 | 4 | 11,760 | Josh Outman | Zachary Britton | Zachary Britton | Josh Outman | Kevin Gregg | 223 | 238 | -15 |
| 2011-06-09 | @ CHA | 64 | L 4-9 | 27-37 | 4 | 22,170 | Trevor Cahill | Mark Buehrle | Mark Buehrle | Trevor Cahill | | 227 | 247 | -20 |
| 2011-06-10 | @ CHA | 65 | W 7-5 | 28-37 | 4 | 20,166 | Graham Godfrey | Edwin Jackson | Grant Balfour | Sergio Santos | Andrew Bailey | 234 | 252 | -18 |
| 2011-06-11 | @ CHA | 66 | L 2-3 | 28-38 | 4 | 24,391 | Gio Gonzalez | John Danks | John Danks | Gio Gonzalez | Jesse Crain | 236 | 255 | -19 |
| 2011-06-12 | @ CHA | 67 | L 4-5 | 28-39 | 4 | 22,144 | Guillermo Moscoso | Philip Humber | Philip Humber | Guillermo Moscoso | Sergio Santos | 240 | 260 | -20 |
| 2011-06-14 | vs KCA | 68 | L 4-7 | 28-40 | 4 | 11,439 | Trevor Cahill | Danny Duffy | Danny Duffy | Trevor Cahill | Joakim Soria | 244 | 267 | -23 |
| 2011-06-15 | vs KCA | 69 | W 2-1 | 29-40 | 4 | 16,392 | Josh Outman | Luke Hochevar | Josh Outman | Luke Hochevar | Andrew Bailey | 246 | 268 | -22 |
| 2011-06-16 | vs KCA | 70 | W 8-4 | 30-40 | 4 | 11,775 | Gio Gonzalez | Jeff Francis | Gio Gonzalez | Jeff Francis | | 254 | 272 | -18 |
| 2011-06-17 | vs SFN | 71 | W 5-2 | 31-40 | 4 | 36,067 | Graham Godfrey | Tim Lincecum | Graham Godfrey | Tim Lincecum | Andrew Bailey | 259 | 274 | -15 |
| 2011-06-18 | vs SFN | 72 | W 4-2 | 32-40 | 4 | 36,067 | Guillermo Moscoso | Jonathan Sanchez | Brad Ziegler | Jonathan Sanchez | Andrew Bailey | 263 | 276 | -13 |
| 2011-06-19 | vs SFN | 73 | W 2-1 | 33-40 | 4 | 36,067 | Trevor Cahill | Matt Cain | Trevor Cahill | Jeremy Affeldt | Brian Fuentes | 265 | 277 | -12 |
| 2011-06-21 | @ NYN | 74 | W 7-3 | 34-40 | 4 | 37,019 | Josh Outman | Dillon Gee | Josh Outman | Dillon Gee | Grant Balfour | 272 | 280 | -8 |
| 2011-06-22 | @ NYN | 75 | L 2-3 | 34-41 | 4 | 38,813 | Gio Gonzalez | R.A. Dickey | Bobby Parnell | Brad Ziegler | | 274 | 283 | -9 |
| 2011-06-23 | @ NYN | 76 | L 1-4 | 34-42 | 4 | 30,168 | Graham Godfrey | Chris Capuano | Chris Capuano | Graham Godfrey | Francisco Rodriguez | 275 | 287 | -12 |
| 2011-06-24 | @ PHI | 77 | L 0-1 | 34-43 | 4 | 45,685 | Guillermo Moscoso | Vance Worley | Michael Stutes | Brian Fuentes | | 275 | 288 | -13 |
| 2011-06-25 | @ PHI | 78 | W 4-1 | 35-43 | 4 | 45,785 | Trevor Cahill | Cole Hamels | Trevor Cahill | Cole Hamels | Andrew Bailey | 279 | 289 | -10 |
| 2011-06-26 | @ PHI | 79 | L 1-3 | 35-44 | 4 | 45,863 | Josh Outman | Roy Halladay | Roy Halladay | Josh Outman | | 280 | 292 | -12 |
| 2011-06-28 | vs FLO | 80 | W 1-0 | 36-44 | 4 | 12,124 | Gio Gonzalez | Javier Vazquez | Gio Gonzalez | Javier Vazquez | Andrew Bailey | 281 | 292 | -11 |
| 2011-06-29 | vs FLO | 81 | L 0-3 | 36-45 | 4 | 17,006 | Guillermo Moscoso | Ricky Nolasco | Ricky Nolasco | Guillermo Moscoso | | 281 | 295 | -14 |
| 2011-06-30 | vs FLO | 82 | L 4-5 | 36-46 | 4 | 18,395 | Trevor Cahill | Chris Volstad | Chris Volstad | Trevor Cahill | Leo Nunez | 285 | 300 | -15 |
| 2011-07-01 | vs ARI | 83 | W 5-4 | 37-46 | 4 | 12,216 | Rich Harden | Josh Collmenter | Rich Harden | Josh Collmenter | Andrew Bailey | 290 | 304 | -14 |
| 2011-07-02 | vs ARI | 84 | L 2-4 | 37-47 | 4 | 30,338 | Josh Outman | Joe Saunders | Joe Saunders | Josh Outman | David Hernandez | 292 | 308 | -16 |
| 2011-07-03 | vs ARI | 85 | W 7-2 | 38-47 | 4 | 13,822 | Gio Gonzalez | Ian Kennedy | Gio Gonzalez | Ian Kennedy | | 299 | 310 | -11 |
| 2011-07-04 | vs SEA | 86 | L 1-2 | 38-48 | 4 | 15,566 | Brandon McCarthy | Michael Pineda | Michael Pineda | Brandon McCarthy | Brandon League | 300 | 312 | -12 |
| 2011-07-05 | vs SEA | 87 | L 2-4 | 38-49 | 4 | 11,153 | Trevor Cahill | Felix Hernandez | Brandon League | Andrew Bailey | Jamey Wright | 302 | 316 | -14 |
| 2011-07-06 | vs SEA | 88 | W 2-0 | 39-49 | 4 | 19,491 | Guillermo Moscoso | Jason Vargas | Guillermo Moscoso | Jason Vargas | Andrew Bailey | 304 | 316 | -12 |
| 2011-07-07 | @ TEX | 89 | L 0-6 | 39-50 | 4 | 35,041 | Rich Harden | Derek Holland | Derek Holland | Rich Harden | | 304 | 322 | -18 |
| 2011-07-08 | @ TEX | 90 | L 5-8 | 39-51 | 4 | 37,858 | Gio Gonzalez | C.J. Wilson | C.J. Wilson | Gio Gonzalez | | 309 | 330 | -21 |
| 2011-07-09 | @ TEX | 91 | L 6-7 | 39-52 | 4 | 34,066 | Brandon McCarthy | Colby Lewis | Darren Oliver | Andrew Bailey | | 315 | 337 | -22 |
| 2011-07-10 | @ TEX | 92 | L 0-2 | 39-53 | 4 | 33,834 | Trevor Cahill | Matt Harrison | Matt Harrison | Trevor Cahill | Neftali Feliz | 315 | 339 | -24 |
| 2011-07-15 | vs ANA | 93 | W 5-3 | 40-53 | 4 | 18,470 | Brandon McCarthy | Dan Haren | Brandon McCarthy | Dan Haren | Andrew Bailey | 320 | 342 | -22 |
| 2011-07-16 | vs ANA | 94 | L 2-4 | 40-54 | 6 | 0 | Trevor Cahill | Jered Weaver | Jered Weaver | Trevor Cahill | Jordan Walden | 322 | 346 | -24 |
| 2011-07-16 | vs ANA | 95 | W 4-3 | 40-54 | 6 | 27,379 | Rich Harden | Ervin Santana | Brad Ziegler | Rich Thompson | | 326 | 349 | -23 |
| 2011-07-17 | vs ANA | 96 | W 9-1 | 42-54 | 4 | 26,115 | Gio Gonzalez | Joel Pineiro | Gio Gonzalez | Joel Pineiro | | 335 | 350 | -15 |
| 2011-07-19 | @ DET | 97 | L 3-8 | 42-55 | 4 | 31,980 | Guillermo Moscoso | Rick Porcello | Rick Porcello | Guillermo Moscoso | | 338 | 358 | -20 |
| 2011-07-20 | @ DET | 98 | W 7-5 | 43-55 | 4 | 31,975 | Brandon McCarthy | Duane Below | Joey Devine | David Purcey | Andrew Bailey | 345 | 363 | -18 |
| 2011-07-22 | @ NYA | 99 | L 7-17 | 43-56 | 3 | 46,921 | Trevor Cahill | Phil Hughes | Hector Noesi | Trevor Cahill | | 352 | 380 | -28 |
| 2011-07-23 | @ NYA | 100 | W 4-3 | 44-56 | 3 | 46,188 | Rich Harden | A.J. Burnett | Rich Harden | A.J. Burnett | Andrew Bailey | 356 | 383 | -27 |
| 2011-07-24 | @ NYA | 101 | L 5-7 | 44-57 | 3 | 45,586 | Gio Gonzalez | Bartolo Colon | Bartolo Colon | Gio Gonzalez | Mariano Rivera | 361 | 390 | -29 |
| 2011-07-25 | vs TBA | 102 | W 7-5 | 45-57 | 3 | 11,053 | Guillermo Moscoso | Jeremy Hellickson | Brian Fuentes | J.P. Howell | Andrew Bailey | 368 | 395 | -27 |
| 2011-07-26 | vs TBA | 103 | W 6-1 | 46-57 | 3 | 12,166 | Brandon McCarthy | David Price | Brandon McCarthy | David Price | | 374 | 396 | -22 |
| 2011-07-27 | vs TBA | 104 | W 13-4 | 47-57 | 3 | 18,640 | Trevor Cahill | James Shields | Trevor Cahill | James Shields | | 387 | 400 | -13 |
| 2011-07-28 | vs TBA | 105 | L 8-10 | 47-58 | 3 | 16,466 | Rich Harden | Wade Davis | Wade Davis | Brad Ziegler | Kyle Farnsworth | 395 | 410 | -15 |
| 2011-07-29 | vs MIN | 106 | L 5-9 | 47-59 | 3 | 25,656 | Gio Gonzalez | Francisco Liriano | Francisco Liriano | Gio Gonzalez | | 400 | 419 | -19 |
| 2011-07-30 | vs MIN | 107 | W 8-3 | 48-59 | 3 | 19,605 | Guillermo Moscoso | Nick Blackburn | Guillermo Moscoso | Nick Blackburn | | 408 | 422 | -14 |
| 2011-07-31 | vs MIN | 108 | W 7-3 | 49-59 | 3 | 22,452 | Brandon McCarthy | Carl Pavano | Brandon McCarthy | Carl Pavano | | 415 | 425 | -10 |
| 2011-08-01 | @ SEA | 109 | L 4-8 | 49-60 | 3 | 23,335 | Trevor Cahill | Blake Beavan | Blake Beavan | Trevor Cahill | | 419 | 433 | -14 |
| 2011-08-02 | @ SEA | 110 | L 2-4 | 49-61 | 3 | 22,576 | Rich Harden | Felix Hernandez | Felix Hernandez | Rich Harden | Brandon League | 421 | 437 | -16 |
| 2011-08-03 | @ SEA | 111 | L 4-7 | 49-62 | 3 | 29,691 | Gio Gonzalez | Charlie Furbush | Charlie Furbush | Gio Gonzalez | Brandon League | 425 | 444 | -19 |
| 2011-08-05 | @ TBA | 112 | L 4-8 | 49-63 | 3 | 15,168 | Guillermo Moscoso | Jeff Niemann | Jeff Niemann | Guillermo Moscoso | | 429 | 452 | -23 |
| 2011-08-06 | @ TBA | 113 | W 8-0 | 50-63 | 3 | 24,939 | Brandon McCarthy | Alex Cobb | Brandon McCarthy | Alex Cobb | | 437 | 452 | -15 |
| 2011-08-07 | @ TBA | 114 | W 5-4 | 51-63 | 3 | 21,425 | Trevor Cahill | David Price | Fautino de los Santos | Jake McGee | Andrew Bailey | 442 | 456 | -14 |
| 2011-08-09 | @ TOR | 115 | W 4-1 | 52-63 | 3 | 20,521 | Rich Harden | Brett Cecil | Rich Harden | Brett Cecil | Andrew Bailey | 446 | 457 | -11 |
| 2011-08-10 | @ TOR | 116 | L 4-8 | 52-64 | 3 | 19,541 | Gio Gonzalez | Henderson Alvarez | Casey Janssen | Gio Gonzalez | Jesse Litsch | 450 | 465 | -15 |
| 2011-08-11 | @ TOR | 117 | W 10-3 | 53-64 | 3 | 27,918 | Guillermo Moscoso | Brad Mills | Guillermo Moscoso | Brad Mills | | 460 | 468 | -8 |
| 2011-08-12 | vs TEX | 118 | L 1-9 | 53-65 | 3 | 20,288 | Brandon McCarthy | C.J. Wilson | C.J. Wilson | Brandon McCarthy | | 461 | 477 | -16 |
| 2011-08-13 | vs TEX | 119 | L 1-7 | 53-66 | 3 | 25,160 | Trevor Cahill | Colby Lewis | Colby Lewis | Trevor Cahill | | 462 | 484 | -22 |
| 2011-08-14 | vs TEX | 120 | L 6-7 | 53-67 | 3 | 15,107 | Rich Harden | Matt Harrison | Mike Adams | Andrew Bailey | Neftali Feliz | 468 | 491 | -23 |
| 2011-08-15 | vs BAL | 121 | L 2-6 | 53-68 | 4 | 10,122 | Gio Gonzalez | Tommy Hunter | Tommy Hunter | Gio Gonzalez | | 470 | 497 | -27 |
| 2011-08-16 | vs BAL | 122 | W 8-4 | 54-68 | 3 | 12,325 | Guillermo Moscoso | Brian Matusz | Guillermo Moscoso | Brian Matusz | | 478 | 501 | -23 |
| 2011-08-17 | vs BAL | 123 | W 6-5 | 55-68 | 3 | 20,448 | Brandon McCarthy | Alfredo Simon | Brandon McCarthy | Alfredo Simon | Andrew Bailey | 484 | 506 | -22 |
| 2011-08-18 | vs TOR | 124 | L 0-7 | 55-69 | 3 | 12,220 | Trevor Cahill | Ricky Romero | Ricky Romero | Trevor Cahill | | 484 | 513 | -29 |
| 2011-08-19 | vs TOR | 125 | W 2-0 | 56-69 | 3 | 13,174 | Rich Harden | Brett Cecil | Rich Harden | Brett Cecil | Andrew Bailey | 486 | 513 | -27 |
| 2011-08-20 | vs TOR | 126 | W 5-1 | 57-69 | 3 | 28,434 | Gio Gonzalez | Henderson Alvarez | Gio Gonzalez | Henderson Alvarez | | 491 | 514 | -23 |
| 2011-08-21 | vs TOR | 127 | L 0-1 | 57-70 | 3 | 16,811 | Guillermo Moscoso | Luis Perez | Luis Perez | Guillermo Moscoso | Casey Janssen | 491 | 515 | -24 |
| 2011-08-23 | @ NYA | 128 | W 6-5 | 58-70 | 3 | 47,343 | Brandon McCarthy | Bartolo Colon | Brandon McCarthy | Bartolo Colon | Andrew Bailey | 497 | 520 | -23 |
| 2011-08-24 | @ NYA | 129 | W 6-4 | 59-70 | 3 | 47,271 | Trevor Cahill | CC Sabathia | Fautino de los Santos | Rafael Soriano | Andrew Bailey | 503 | 524 | -21 |
| 2011-08-25 | @ NYA | 130 | L 9-22 | 59-71 | 3 | 46,369 | Rich Harden | Phil Hughes | Boone Logan | Fautino de los Santos | | 512 | 546 | -34 |
| 2011-08-26 | @ BOS | 131 | W 15-5 | 60-71 | 3 | 38,239 | Gio Gonzalez | Tim Wakefield | Gio Gonzalez | Tim Wakefield | | 527 | 551 | -24 |
| 2011-08-27 | @ BOS | 132 | L 3-9 | 60-73 | 4 | 37,314 | Guillermo Moscoso | Jon Lester | Jon Lester | Guillermo Moscoso | | 530 | 560 | -30 |
| 2011-08-27 | @ BOS | 133 | L 0-4 | 60-73 | 4 | 37,039 | Graham Godfrey | Erik Bedard | Alfredo Aceves | Graham Godfrey | | 530 | 564 | -34 |
| 2011-08-29 | @ CLE | 134 | L 1-2 | 60-74 | 3 | 18,201 | Brandon McCarthy | David Huff | David Huff | Brandon McCarthy | Chris Perez | 531 | 566 | -35 |
| 2011-08-30 | @ CLE | 135 | L 2-6 | 60-75 | 3 | 20,372 | Trevor Cahill | Jeanmar Gomez | Jeanmar Gomez | Trevor Cahill | | 533 | 572 | -39 |
| 2011-08-31 | @ CLE | 136 | L 3-4 | 60-76 | 3 | 15,202 | Rich Harden | Ubaldo Jimenez | Frank Herrmann | Josh Outman | | 536 | 576 | -40 |
| 2011-09-01 | @ CLE | 137 | W 7-0 | 61-76 | 3 | 14,192 | Gio Gonzalez | Fausto Carmona | Gio Gonzalez | Fausto Carmona | | 543 | 576 | -33 |
| 2011-09-02 | vs SEA | 138 | W 9-2 | 62-76 | 3 | 14,972 | Guillermo Moscoso | Jason Vargas | Guillermo Moscoso | Jason Vargas | | 552 | 578 | -26 |
| 2011-09-03 | vs SEA | 139 | W 3-0 | 63-76 | 3 | 19,732 | Brandon McCarthy | Michael Pineda | Brandon McCarthy | Michael Pineda | | 555 | 578 | -23 |
| 2011-09-04 | vs SEA | 140 | W 8-5 | 64-76 | 3 | 19,384 | Trevor Cahill | Blake Beavan | Trevor Cahill | Blake Beavan | Andrew Bailey | 563 | 583 | -20 |
| 2011-09-05 | vs KCA | 141 | L 6-11 | 64-77 | 3 | 14,577 | Rich Harden | Felipe Paulino | Greg Holland | Andrew Bailey | | 569 | 594 | -25 |
| 2011-09-06 | vs KCA | 142 | L 4-7 | 64-78 | 3 | 12,064 | Gio Gonzalez | Danny Duffy | Danny Duffy | Gio Gonzalez | Joakim Soria | 573 | 601 | -28 |
| 2011-09-07 | vs KCA | 143 | W 7-0 | 65-78 | 3 | 13,132 | Guillermo Moscoso | Bruce Chen | Guillermo Moscoso | Bruce Chen | | 580 | 601 | -21 |
| 2011-09-09 | @ TEX | 144 | L 4-13 | 65-79 | 3 | 36,706 | Brandon McCarthy | Colby Lewis | Colby Lewis | Brandon McCarthy | | 584 | 614 | -30 |
| 2011-09-10 | @ TEX | 145 | W 8-7 | 66-79 | 3 | 46,151 | Trevor Cahill | Alexi Ogando | Trevor Cahill | Alexi Ogando | Andrew Bailey | 592 | 621 | -29 |
| 2011-09-11 | @ TEX | 146 | L 1-8 | 66-80 | 3 | 46,727 | Josh Outman | C.J. Wilson | C.J. Wilson | Josh Outman | | 593 | 629 | -36 |
| 2011-09-12 | vs ANA | 147 | W 6-3 | 67-80 | 3 | 12,858 | Gio Gonzalez | Joel Pineiro | Gio Gonzalez | Joel Pineiro | | 599 | 632 | -33 |
| 2011-09-13 | vs ANA | 148 | L 3-6 | 67-81 | 3 | 13,212 | Guillermo Moscoso | Jerome Williams | Hisanori Takahashi | Fautino de los Santos | Jordan Walden | 602 | 638 | -36 |
| 2011-09-14 | vs ANA | 149 | L 1-4 | 67-82 | 3 | 14,743 | Rich Harden | Jered Weaver | Jered Weaver | Rich Harden | Jordan Walden | 603 | 642 | -39 |
| 2011-09-15 | vs DET | 150 | W 6-1 | 68-82 | 3 | 10,925 | Brandon McCarthy | Max Scherzer | Brandon McCarthy | Max Scherzer | | 609 | 643 | -34 |
| 2011-09-16 | vs DET | 151 | L 1-3 | 68-83 | 3 | 31,022 | Trevor Cahill | Doug Fister | Doug Fister | Trevor Cahill | Jose Valverde | 610 | 646 | -36 |
| 2011-09-17 | vs DET | 152 | W 5-3 | 69-83 | 3 | 19,451 | Gio Gonzalez | Rick Porcello | Gio Gonzalez | Rick Porcello | | 615 | 649 | -34 |
| 2011-09-18 | vs DET | 153 | L 0-3 | 69-84 | 3 | 18,405 | Guillermo Moscoso | Justin Verlander | Justin Verlander | Guillermo Moscoso | Jose Valverde | 615 | 652 | -37 |
| 2011-09-20 | vs TEX | 154 | L 2-7 | 69-85 | 3 | 13,635 | Rich Harden | Derek Holland | Derek Holland | Rich Harden | | 617 | 659 | -42 |
| 2011-09-21 | vs TEX | 155 | L 2-3 | 69-86 | 3 | 19,589 | Brandon McCarthy | C.J. Wilson | Koji Uehara | Grant Balfour | Neftali Feliz | 619 | 662 | -43 |
| 2011-09-22 | vs TEX | 156 | W 4-3 | 70-86 | 3 | 14,090 | Trevor Cahill | Colby Lewis | Grant Balfour | Mike Adams | Andrew Bailey | 623 | 665 | -42 |
| 2011-09-23 | @ ANA | 157 | W 3-1 | 71-86 | 3 | 39,217 | Gio Gonzalez | Jered Weaver | Gio Gonzalez | Jered Weaver | Andrew Bailey | 626 | 666 | -40 |
| 2011-09-24 | @ ANA | 158 | L 2-4 | 71-87 | 3 | 41,113 | Guillermo Moscoso | Jerome Williams | Jerome Williams | Guillermo Moscoso | Jordan Walden | 628 | 670 | -42 |
| 2011-09-25 | @ ANA | 159 | W 6-5 | 72-87 | 3 | 40,794 | Rich Harden | Joel Pineiro | Fautino de los Santos | Jordan Walden | Andrew Bailey | 634 | 675 | -41 |
| 2011-09-26 | @ SEA | 160 | L 2-4 | 72-88 | 3 | 17,057 | Brandon McCarthy | Jason Vargas | Jason Vargas | Brandon McCarthy | Brandon League | 636 | 679 | -43 |
| 2011-09-27 | @ SEA | 161 | W 7-0 | 73-88 | 3 | 18,600 | Trevor Cahill | Blake Beavan | Trevor Cahill | Blake Beavan | | 643 | 679 | -36 |
| 2011-09-28 | @ SEA | 162 | W 2-0 | 74-88 | 3 | 20,173 | Gio Gonzalez | Anthony Vasquez | Gio Gonzalez | Anthony Vasquez | Andrew Bailey | 645 | 679 | -34 |