| 2011-03-31 | vs DET | 1 | W 6-3 | 1-0 | 1 | 48,226 | CC Sabathia | Justin Verlander | Joba Chamberlain | Phil Coke | Mariano Rivera | 6 | 3 | 3 |
| 2011-04-02 | vs DET | 2 | W 10-6 | 2-0 | 2 | 41,462 | A.J. Burnett | Brad Penny | A.J. Burnett | Brad Penny | Mariano Rivera | 16 | 9 | 7 |
| 2011-04-03 | vs DET | 3 | L 7-10 | 2-1 | 2 | 40,574 | Phil Hughes | Max Scherzer | Max Scherzer | Phil Hughes | Jose Valverde | 23 | 19 | 4 |
| 2011-04-04 | vs MIN | 4 | W 4-3 | 3-1 | 2 | 40,311 | Ivan Nova | Scott Baker | Ivan Nova | Scott Baker | Mariano Rivera | 27 | 22 | 5 |
| 2011-04-05 | vs MIN | 5 | L 4-5 | 3-2 | 3 | 40,267 | CC Sabathia | Brian Duensing | Matt Capps | Boone Logan | Joe Nathan | 31 | 27 | 4 |
| 2011-04-07 | vs MIN | 6 | W 4-3 | 4-2 | 2 | 41,512 | A.J. Burnett | Francisco Liriano | A.J. Burnett | Francisco Liriano | Mariano Rivera | 35 | 30 | 5 |
| 2011-04-08 | @ BOS | 7 | L 6-9 | 4-3 | 3 | 37,178 | Phil Hughes | John Lackey | John Lackey | Bartolo Colon | Jonathan Papelbon | 41 | 39 | 2 |
| 2011-04-09 | @ BOS | 8 | W 9-4 | 5-3 | 3 | 37,488 | Ivan Nova | Clay Buchholz | David Robertson | Clay Buchholz | | 50 | 43 | 7 |
| 2011-04-10 | @ BOS | 9 | L 0-4 | 5-4 | 2 | 37,861 | CC Sabathia | Josh Beckett | Josh Beckett | CC Sabathia | | 50 | 47 | 3 |
| 2011-04-13 | vs BAL | 10 | W 7-4 | 6-4 | 2 | 42,171 | A.J. Burnett | Chris Tillman | A.J. Burnett | Chris Tillman | Mariano Rivera | 57 | 51 | 6 |
| 2011-04-14 | vs BAL | 11 | W 6-5 | 7-4 | 1 | 40,517 | Phil Hughes | Jake Arrieta | Mariano Rivera | Mike Gonzalez | | 63 | 56 | 7 |
| 2011-04-15 | vs TEX | 12 | L 3-5 | 7-5 | 1 | 40,814 | Ivan Nova | Matt Harrison | Matt Harrison | Ivan Nova | Neftali Feliz | 66 | 61 | 5 |
| 2011-04-16 | vs TEX | 13 | W 5-2 | 8-5 | 1 | 41,876 | Freddy Garcia | Derek Holland | Freddy Garcia | Derek Holland | Mariano Rivera | 71 | 63 | 8 |
| 2011-04-17 | vs TEX | 14 | W 6-5 | 9-5 | 1 | 40,811 | CC Sabathia | Alexi Ogando | Rafael Soriano | Arthur Rhodes | Mariano Rivera | 77 | 68 | 9 |
| 2011-04-19 | @ TOR | 15 | L 5-6 | 9-6 | 1 | 25,250 | A.J. Burnett | Kyle Drabek | Jon Rauch | Ivan Nova | | 82 | 74 | 8 |
| 2011-04-20 | @ TOR | 16 | W 6-2 | 10-6 | 1 | 26,062 | Bartolo Colon | Brett Cecil | Bartolo Colon | Brett Cecil | Rafael Soriano | 88 | 76 | 12 |
| 2011-04-23 | @ BAL | 17 | W 15-3 | 11-6 | 1 | 39,054 | CC Sabathia | Brad Bergesen | CC Sabathia | Brad Bergesen | | 103 | 79 | 24 |
| 2011-04-24 | @ BAL | 18 | W 6-3 | 12-6 | 1 | 25,051 | Freddy Garcia | Jake Arrieta | Boone Logan | Jason Berken | | 109 | 82 | 27 |
| 2011-04-25 | vs CHA | 19 | L 0-2 | 12-7 | 1 | 40,506 | A.J. Burnett | Philip Humber | Philip Humber | A.J. Burnett | Sergio Santos | 109 | 84 | 25 |
| 2011-04-26 | vs CHA | 20 | L 2-3 | 12-8 | 1 | 40,785 | Ivan Nova | Gavin Floyd | Gavin Floyd | Rafael Soriano | Sergio Santos | 111 | 87 | 24 |
| 2011-04-27 | vs CHA | 21 | W 3-1 | 13-8 | 1 | 40,586 | Bartolo Colon | Mark Buehrle | Bartolo Colon | Mark Buehrle | Mariano Rivera | 114 | 88 | 26 |
| 2011-04-28 | vs CHA | 22 | W 12-3 | 14-8 | 1 | 40,081 | CC Sabathia | Edwin Jackson | CC Sabathia | Edwin Jackson | | 126 | 91 | 35 |
| 2011-04-29 | vs TOR | 23 | L 3-5 | 14-9 | 1 | 40,830 | Freddy Garcia | Ricky Romero | Ricky Romero | Freddy Garcia | Jon Rauch | 129 | 96 | 33 |
| 2011-04-30 | vs TOR | 24 | W 5-4 | 15-9 | 1 | 42,460 | A.J. Burnett | Kyle Drabek | A.J. Burnett | Kyle Drabek | Mariano Rivera | 134 | 100 | 34 |
| 2011-05-01 | vs TOR | 25 | W 5-2 | 16-9 | 1 | 43,363 | Ivan Nova | Jesse Litsch | Ivan Nova | Jesse Litsch | Mariano Rivera | 139 | 102 | 37 |
| 2011-05-02 | @ DET | 26 | W 5-3 | 17-9 | 1 | 22,852 | Bartolo Colon | Justin Verlander | Joba Chamberlain | Jose Valverde | Mariano Rivera | 144 | 105 | 39 |
| 2011-05-03 | @ DET | 27 | L 2-4 | 17-10 | 1 | 23,551 | CC Sabathia | Brad Penny | Brad Penny | CC Sabathia | Jose Valverde | 146 | 109 | 37 |
| 2011-05-04 | @ DET | 28 | L 0-4 | 17-11 | 1 | 22,569 | Freddy Garcia | Max Scherzer | Max Scherzer | Freddy Garcia | | 146 | 113 | 33 |
| 2011-05-05 | @ DET | 29 | L 3-6 | 17-12 | 1 | 30,572 | A.J. Burnett | Rick Porcello | Rick Porcello | A.J. Burnett | | 149 | 119 | 30 |
| 2011-05-06 | @ TEX | 30 | W 4-1 | 18-12 | 1 | 49,069 | Ivan Nova | Matt Harrison | Ivan Nova | Matt Harrison | Mariano Rivera | 153 | 120 | 33 |
| 2011-05-07 | @ TEX | 31 | L 5-7 | 18-13 | 1 | 49,574 | Bartolo Colon | Derek Holland | Arthur Rhodes | Boone Logan | Neftali Feliz | 158 | 127 | 31 |
| 2011-05-08 | @ TEX | 32 | W 12-5 | 19-13 | 1 | 48,057 | CC Sabathia | David Bush | CC Sabathia | Arthur Rhodes | | 170 | 132 | 38 |
| 2011-05-10 | vs KCA | 33 | W 3-1 | 20-13 | 1 | 41,275 | Freddy Garcia | Kyle Davies | Freddy Garcia | Kyle Davies | Mariano Rivera | 173 | 133 | 40 |
| 2011-05-11 | vs KCA | 34 | L 3-4 | 20-14 | 1 | 40,164 | A.J. Burnett | Vin Mazzaro | Joakim Soria | Buddy Carlyle | Louis Coleman | 176 | 137 | 39 |
| 2011-05-12 | vs KCA | 35 | L 5-11 | 20-15 | 2 | 41,790 | Ivan Nova | Sean O'Sullivan | Sean O'Sullivan | Ivan Nova | | 181 | 148 | 33 |
| 2011-05-13 | vs BOS | 36 | L 4-5 | 20-16 | 2 | 48,254 | Bartolo Colon | Clay Buchholz | Clay Buchholz | Bartolo Colon | Jonathan Papelbon | 185 | 153 | 32 |
| 2011-05-14 | vs BOS | 37 | L 0-6 | 20-17 | 2 | 48,790 | CC Sabathia | Josh Beckett | Josh Beckett | CC Sabathia | | 185 | 159 | 26 |
| 2011-05-15 | vs BOS | 38 | L 5-7 | 20-18 | 2 | 46,945 | Freddy Garcia | Jon Lester | Jon Lester | Freddy Garcia | Jonathan Papelbon | 190 | 166 | 24 |
| 2011-05-16 | @ TBA | 39 | L 5-6 | 20-19 | 2 | 25,024 | A.J. Burnett | David Price | Juan Cruz | A.J. Burnett | Kyle Farnsworth | 195 | 172 | 23 |
| 2011-05-17 | @ TBA | 40 | W 6-2 | 21-19 | 2 | 27,123 | Ivan Nova | James Shields | Ivan Nova | James Shields | | 201 | 174 | 27 |
| 2011-05-18 | @ BAL | 41 | W 4-1 | 22-19 | 2 | 20,589 | Bartolo Colon | Zachary Britton | Hector Noesi | Jeremy Accardo | | 205 | 175 | 30 |
| 2011-05-19 | @ BAL | 42 | W 13-2 | 23-19 | 2 | 24,939 | CC Sabathia | Brad Bergesen | CC Sabathia | Brad Bergesen | | 218 | 177 | 41 |
| 2011-05-20 | vs NYN | 43 | L 1-2 | 23-20 | 3 | 47,874 | Freddy Garcia | R.A. Dickey | R.A. Dickey | Freddy Garcia | Francisco Rodriguez | 219 | 179 | 40 |
| 2011-05-21 | vs NYN | 44 | W 7-3 | 24-20 | 1 | 48,286 | A.J. Burnett | Chris Capuano | A.J. Burnett | Chris Capuano | | 226 | 182 | 44 |
| 2011-05-22 | vs NYN | 45 | W 9-3 | 25-20 | 1 | 48,293 | Ivan Nova | Mike Pelfrey | Luis Ayala | Mike Pelfrey | | 235 | 185 | 50 |
| 2011-05-23 | vs TOR | 46 | L 3-7 | 25-21 | 1 | 41,946 | Bartolo Colon | Carlos Villanueva | Carlos Villanueva | Bartolo Colon | | 238 | 192 | 46 |
| 2011-05-24 | vs TOR | 47 | W 5-4 | 26-21 | 1 | 41,519 | CC Sabathia | Ricky Romero | CC Sabathia | Frank Francisco | | 243 | 196 | 47 |
| 2011-05-25 | vs TOR | 48 | W 7-3 | 27-21 | 1 | 43,201 | Freddy Garcia | Jo-Jo Reyes | Freddy Garcia | Jo-Jo Reyes | | 250 | 199 | 51 |
| 2011-05-27 | @ SEA | 49 | L 3-4 | 27-22 | 2 | 33,715 | A.J. Burnett | Michael Pineda | David Pauley | Luis Ayala | Brandon League | 253 | 203 | 50 |
| 2011-05-28 | @ SEA | 50 | L 4-5 | 27-23 | 2 | 37,354 | Ivan Nova | Felix Hernandez | David Pauley | Mariano Rivera | | 257 | 208 | 49 |
| 2011-05-29 | @ SEA | 51 | W 7-1 | 28-23 | 3 | 37,290 | CC Sabathia | Jason Vargas | CC Sabathia | Jason Vargas | | 264 | 209 | 55 |
| 2011-05-30 | @ OAK | 52 | W 5-0 | 29-23 | 1 | 35,067 | Bartolo Colon | Trevor Cahill | Bartolo Colon | Trevor Cahill | | 269 | 209 | 60 |
| 2011-05-31 | @ OAK | 53 | W 10-3 | 30-23 | 1 | 22,581 | Freddy Garcia | Brett Anderson | Freddy Garcia | Brett Anderson | | 279 | 212 | 67 |
| 2011-06-01 | @ OAK | 54 | W 4-2 | 31-23 | 1 | 25,469 | A.J. Burnett | Gio Gonzalez | A.J. Burnett | Gio Gonzalez | Mariano Rivera | 283 | 214 | 69 |
| 2011-06-03 | @ ANA | 55 | L 2-3 | 31-24 | 1 | 42,521 | Ivan Nova | Jered Weaver | Jered Weaver | Ivan Nova | Jordan Walden | 285 | 217 | 68 |
| 2011-06-04 | @ ANA | 56 | W 3-2 | 32-24 | 1 | 43,619 | CC Sabathia | Ervin Santana | CC Sabathia | Ervin Santana | Mariano Rivera | 288 | 219 | 69 |
| 2011-06-05 | @ ANA | 57 | W 5-3 | 33-24 | 1 | 43,524 | Bartolo Colon | Joel Pineiro | Bartolo Colon | Joel Pineiro | Mariano Rivera | 293 | 222 | 71 |
| 2011-06-07 | vs BOS | 58 | L 4-6 | 33-25 | 1 | 48,450 | Freddy Garcia | Jon Lester | Jon Lester | Freddy Garcia | Jonathan Papelbon | 297 | 228 | 69 |
| 2011-06-08 | vs BOS | 59 | L 6-11 | 33-26 | 2 | 47,863 | A.J. Burnett | Tim Wakefield | Tim Wakefield | A.J. Burnett | Alfredo Aceves | 303 | 239 | 64 |
| 2011-06-09 | vs BOS | 60 | L 3-8 | 33-27 | 2 | 48,845 | CC Sabathia | Josh Beckett | Josh Beckett | CC Sabathia | | 306 | 247 | 59 |
| 2011-06-10 | vs CLE | 61 | W 11-7 | 34-27 | 2 | 45,679 | Ivan Nova | Fausto Carmona | Ivan Nova | Fausto Carmona | | 317 | 254 | 63 |
| 2011-06-11 | vs CLE | 62 | W 4-0 | 35-27 | 2 | 47,048 | Bartolo Colon | Mitch Talbot | Bartolo Colon | Mitch Talbot | | 321 | 254 | 67 |
| 2011-06-12 | vs CLE | 63 | W 9-1 | 36-27 | 2 | 46,791 | Freddy Garcia | Josh Tomlin | Freddy Garcia | Josh Tomlin | | 330 | 255 | 75 |
| 2011-06-13 | vs CLE | 64 | L 0-1 | 36-28 | 2 | 43,551 | A.J. Burnett | Carlos Carrasco | Carlos Carrasco | A.J. Burnett | Chris Perez | 330 | 256 | 74 |
| 2011-06-14 | vs TEX | 65 | W 12-4 | 37-28 | 2 | 43,457 | CC Sabathia | Alexi Ogando | CC Sabathia | Alexi Ogando | | 342 | 260 | 82 |
| 2011-06-15 | vs TEX | 66 | W 12-4 | 38-28 | 2 | 45,969 | Ivan Nova | Derek Holland | Ivan Nova | Derek Holland | | 354 | 264 | 90 |
| 2011-06-16 | vs TEX | 67 | W 3-2 | 39-28 | 2 | 47,487 | Brian Gordon | C.J. Wilson | Cory Wade | Michael Kirkman | | 357 | 266 | 91 |
| 2011-06-17 | @ CHN | 68 | L 1-3 | 39-29 | 2 | 42,219 | Freddy Garcia | Doug Davis | Doug Davis | Freddy Garcia | Carlos Marmol | 358 | 269 | 89 |
| 2011-06-18 | @ CHN | 69 | W 4-3 | 40-29 | 2 | 42,236 | A.J. Burnett | Ryan Dempster | A.J. Burnett | Ryan Dempster | Mariano Rivera | 362 | 272 | 90 |
| 2011-06-19 | @ CHN | 70 | W 10-4 | 41-29 | 2 | 41,828 | CC Sabathia | Randy Wells | CC Sabathia | Sean Marshall | | 372 | 276 | 96 |
| 2011-06-20 | @ CIN | 71 | W 5-3 | 42-29 | 2 | 41,173 | Ivan Nova | Travis Wood | Ivan Nova | Travis Wood | Mariano Rivera | 377 | 279 | 98 |
| 2011-06-22 | @ CIN | 72 | W 4-2 | 43-30 | 3 | 40,010 | Freddy Garcia | Mike Leake | Freddy Garcia | Mike Leake | Mariano Rivera | 381 | 281 | 100 |
| 2011-06-22 | @ CIN | 73 | L 2-10 | 43-30 | 3 | 41,367 | Brian Gordon | Johnny Cueto | Johnny Cueto | Brian Gordon | | 383 | 291 | 92 |
| 2011-06-24 | vs COL | 74 | L 2-4 | 43-31 | 2 | 46,028 | A.J. Burnett | Ubaldo Jimenez | Ubaldo Jimenez | A.J. Burnett | Huston Street | 385 | 295 | 90 |
| 2011-06-25 | vs COL | 75 | W 8-3 | 44-31 | 1 | 46,900 | CC Sabathia | Aaron Cook | CC Sabathia | Aaron Cook | | 393 | 298 | 95 |
| 2011-06-26 | vs COL | 76 | W 6-4 | 45-31 | 1 | 47,894 | Ivan Nova | Juan Nicasio | Boone Logan | Matt Belisle | Mariano Rivera | 399 | 302 | 97 |
| 2011-06-28 | vs MIL | 77 | W 12-2 | 46-31 | 1 | 45,575 | Freddy Garcia | Zack Greinke | Freddy Garcia | Zack Greinke | | 411 | 304 | 107 |
| 2011-06-29 | vs MIL | 78 | W 5-2 | 47-31 | 1 | 46,450 | A.J. Burnett | Shaun Marcum | A.J. Burnett | Shaun Marcum | Mariano Rivera | 416 | 306 | 110 |
| 2011-06-30 | vs MIL | 79 | W 5-0 | 48-31 | 1 | 46,903 | CC Sabathia | Randy Wolf | CC Sabathia | Randy Wolf | | 421 | 306 | 115 |
| 2011-07-01 | @ NYN | 80 | W 5-1 | 49-31 | 1 | 42,020 | Ivan Nova | Jonathon Niese | Ivan Nova | Jonathon Niese | | 426 | 307 | 119 |
| 2011-07-02 | @ NYN | 81 | W 5-2 | 50-31 | 1 | 42,042 | Bartolo Colon | Dillon Gee | Bartolo Colon | Dillon Gee | | 431 | 309 | 122 |
| 2011-07-03 | @ NYN | 82 | L 2-3 | 50-32 | 1 | 41,513 | Freddy Garcia | R.A. Dickey | Francisco Rodriguez | Luis Ayala | | 433 | 312 | 121 |
| 2011-07-04 | @ CLE | 83 | L 3-6 | 50-33 | 1 | 40,676 | A.J. Burnett | Josh Tomlin | Josh Tomlin | A.J. Burnett | Chris Perez | 436 | 318 | 118 |
| 2011-07-05 | @ CLE | 84 | W 9-2 | 51-33 | 1 | 30,100 | CC Sabathia | Carlos Carrasco | CC Sabathia | Carlos Carrasco | | 445 | 320 | 125 |
| 2011-07-06 | @ CLE | 85 | L 3-5 | 51-34 | 1 | 31,926 | Phil Hughes | Justin Masterson | Justin Masterson | Phil Hughes | Chris Perez | 448 | 325 | 123 |
| 2011-07-07 | vs TBA | 86 | L 1-5 | 51-35 | 2 | 47,787 | Bartolo Colon | Jeff Niemann | Jeff Niemann | Bartolo Colon | | 449 | 330 | 119 |
| 2011-07-09 | vs TBA | 87 | W 5-4 | 52-35 | 2 | 48,103 | A.J. Burnett | David Price | David Robertson | Joel Peralta | Mariano Rivera | 454 | 334 | 120 |
| 2011-07-10 | vs TBA | 88 | W 1-0 | 53-35 | 2 | 47,350 | CC Sabathia | James Shields | CC Sabathia | James Shields | | 455 | 334 | 121 |
| 2011-07-14 | @ TOR | 89 | L 7-16 | 53-36 | 2 | 37,342 | Bartolo Colon | Jo-Jo Reyes | Jo-Jo Reyes | Bartolo Colon | | 462 | 350 | 112 |
| 2011-07-15 | @ TOR | 90 | L 1-7 | 53-37 | 2 | 33,525 | Freddy Garcia | Brandon Morrow | Brandon Morrow | Freddy Garcia | | 463 | 357 | 106 |
| 2011-07-16 | @ TOR | 91 | W 4-1 | 54-37 | 2 | 45,606 | CC Sabathia | Ricky Romero | CC Sabathia | Ricky Romero | Mariano Rivera | 467 | 358 | 109 |
| 2011-07-17 | @ TOR | 92 | W 7-2 | 55-37 | 2 | 36,586 | Phil Hughes | Carlos Villanueva | Phil Hughes | Carlos Villanueva | | 474 | 360 | 114 |
| 2011-07-18 | @ TBA | 93 | W 5-4 | 56-37 | 2 | 22,471 | A.J. Burnett | Alex Cobb | David Robertson | Alexander Torres | Mariano Rivera | 479 | 364 | 115 |
| 2011-07-19 | @ TBA | 94 | L 2-3 | 56-38 | 2 | 22,780 | Bartolo Colon | Jeremy Hellickson | Jeremy Hellickson | Bartolo Colon | Joel Peralta | 481 | 367 | 114 |
| 2011-07-20 | @ TBA | 95 | W 4-0 | 57-38 | 2 | 21,505 | Freddy Garcia | David Price | Freddy Garcia | David Price | | 485 | 367 | 118 |
| 2011-07-21 | @ TBA | 96 | L 1-2 | 57-39 | 2 | 29,279 | CC Sabathia | James Shields | James Shields | CC Sabathia | Kyle Farnsworth | 486 | 369 | 117 |
| 2011-07-22 | vs OAK | 97 | W 17-7 | 58-39 | 2 | 46,921 | Phil Hughes | Trevor Cahill | Hector Noesi | Trevor Cahill | | 503 | 376 | 127 |
| 2011-07-23 | vs OAK | 98 | L 3-4 | 58-40 | 2 | 46,188 | A.J. Burnett | Rich Harden | Rich Harden | A.J. Burnett | Andrew Bailey | 506 | 380 | 126 |
| 2011-07-24 | vs OAK | 99 | W 7-5 | 59-40 | 2 | 45,586 | Bartolo Colon | Gio Gonzalez | Bartolo Colon | Gio Gonzalez | Mariano Rivera | 513 | 385 | 128 |
| 2011-07-25 | vs SEA | 100 | W 10-3 | 60-40 | 2 | 44,365 | Freddy Garcia | Jason Vargas | Freddy Garcia | Jason Vargas | | 523 | 388 | 135 |
| 2011-07-26 | vs SEA | 101 | W 4-1 | 61-40 | 2 | 46,132 | CC Sabathia | Doug Fister | CC Sabathia | Doug Fister | Mariano Rivera | 527 | 389 | 138 |
| 2011-07-27 | vs SEA | 102 | L 2-9 | 61-41 | 2 | 47,090 | Phil Hughes | Felix Hernandez | Felix Hernandez | Phil Hughes | | 529 | 398 | 131 |
| 2011-07-29 | vs BAL | 103 | L 2-4 | 61-42 | 2 | 46,499 | A.J. Burnett | Jeremy Guthrie | Jeremy Guthrie | A.J. Burnett | Kevin Gregg | 531 | 402 | 129 |
| 2011-07-30 | vs BAL | 104 | W 8-3 | 62-42 | 3 | 46,469 | Bartolo Colon | Chris Tillman | Bartolo Colon | Chris Tillman | | 539 | 405 | 134 |
| 2011-07-30 | vs BAL | 105 | W 17-3 | 62-42 | 3 | 43,190 | Ivan Nova | Zachary Britton | Ivan Nova | Zachary Britton | | 556 | 408 | 148 |
| 2011-07-31 | vs BAL | 106 | W 4-2 | 64-42 | 2 | 46,913 | Freddy Garcia | Jake Arrieta | Freddy Garcia | Jake Arrieta | Mariano Rivera | 560 | 410 | 150 |
| 2011-08-01 | @ CHA | 107 | W 3-2 | 65-42 | 2 | 24,142 | CC Sabathia | Jake Peavy | CC Sabathia | Jake Peavy | Mariano Rivera | 563 | 412 | 151 |
| 2011-08-02 | @ CHA | 108 | W 6-0 | 66-42 | 2 | 21,661 | Phil Hughes | John Danks | Phil Hughes | John Danks | | 569 | 412 | 157 |
| 2011-08-03 | @ CHA | 109 | W 18-7 | 67-42 | 2 | 23,873 | A.J. Burnett | Gavin Floyd | Cory Wade | Gavin Floyd | | 587 | 419 | 168 |
| 2011-08-04 | @ CHA | 110 | W 7-2 | 68-42 | 2 | 28,088 | Ivan Nova | Philip Humber | Ivan Nova | Philip Humber | | 594 | 421 | 173 |
| 2011-08-05 | @ BOS | 111 | W 3-2 | 69-42 | 1 | 38,006 | Bartolo Colon | Jon Lester | Boone Logan | Jon Lester | Mariano Rivera | 597 | 423 | 174 |
| 2011-08-06 | @ BOS | 112 | L 4-10 | 69-43 | 2 | 37,416 | CC Sabathia | John Lackey | John Lackey | CC Sabathia | | 601 | 433 | 168 |
| 2011-08-07 | @ BOS | 113 | L 2-3 | 69-44 | 2 | 38,189 | Freddy Garcia | Josh Beckett | Daniel Bard | Phil Hughes | | 603 | 436 | 167 |
| 2011-08-09 | vs ANA | 114 | L 4-6 | 69-45 | 2 | 46,466 | A.J. Burnett | Dan Haren | Scott Downs | Mariano Rivera | Jordan Walden | 607 | 442 | 165 |
| 2011-08-10 | vs ANA | 115 | W 9-3 | 70-45 | 2 | 46,967 | Ivan Nova | Garrett Richards | Ivan Nova | Garrett Richards | | 616 | 445 | 171 |
| 2011-08-11 | vs ANA | 116 | W 6-5 | 71-45 | 2 | 47,431 | Bartolo Colon | Tyler Chatwood | Rafael Soriano | Fernando Rodney | Mariano Rivera | 622 | 450 | 172 |
| 2011-08-12 | vs TBA | 117 | L 1-5 | 71-46 | 2 | 47,894 | CC Sabathia | David Price | David Price | CC Sabathia | | 623 | 455 | 168 |
| 2011-08-13 | vs TBA | 118 | W 9-2 | 72-46 | 2 | 47,804 | Phil Hughes | Jeremy Hellickson | Phil Hughes | Jeremy Hellickson | | 632 | 457 | 175 |
| 2011-08-15 | @ KCA | 119 | W 7-4 | 73-46 | 1 | 24,879 | A.J. Burnett | Felipe Paulino | A.J. Burnett | Felipe Paulino | Mariano Rivera | 639 | 461 | 178 |
| 2011-08-16 | @ KCA | 120 | W 9-7 | 74-46 | 2 | 22,258 | Ivan Nova | Danny Duffy | Ivan Nova | Danny Duffy | Mariano Rivera | 648 | 468 | 180 |
| 2011-08-17 | @ KCA | 121 | L 4-5 | 74-47 | 1 | 22,435 | Bartolo Colon | Bruce Chen | Bruce Chen | Bartolo Colon | Joakim Soria | 652 | 473 | 179 |
| 2011-08-18 | @ MIN | 122 | W 8-4 | 75-47 | 1 | 41,126 | CC Sabathia | Brian Duensing | CC Sabathia | Brian Duensing | | 660 | 477 | 183 |
| 2011-08-19 | @ MIN | 123 | W 8-1 | 76-47 | 1 | 41,328 | Phil Hughes | Kevin Slowey | Phil Hughes | Kevin Slowey | | 668 | 478 | 190 |
| 2011-08-20 | @ MIN | 124 | L 4-9 | 76-48 | 1 | 41,254 | A.J. Burnett | Francisco Liriano | Francisco Liriano | A.J. Burnett | | 672 | 487 | 185 |
| 2011-08-21 | @ MIN | 125 | W 3-0 | 77-48 | 1 | 41,242 | Ivan Nova | Nick Blackburn | Ivan Nova | Phil Dumatrait | Mariano Rivera | 675 | 487 | 188 |
| 2011-08-23 | vs OAK | 126 | L 5-6 | 77-49 | 1 | 47,343 | Bartolo Colon | Brandon McCarthy | Brandon McCarthy | Bartolo Colon | Andrew Bailey | 680 | 493 | 187 |
| 2011-08-24 | vs OAK | 127 | L 4-6 | 77-50 | 2 | 47,271 | CC Sabathia | Trevor Cahill | Fautino de los Santos | Rafael Soriano | Andrew Bailey | 684 | 499 | 185 |
| 2011-08-25 | vs OAK | 128 | W 22-9 | 78-50 | 2 | 46,369 | Phil Hughes | Rich Harden | Boone Logan | Fautino de los Santos | | 706 | 508 | 198 |
| 2011-08-26 | @ BAL | 129 | L 5-12 | 78-51 | 2 | 32,762 | A.J. Burnett | Tommy Hunter | Tommy Hunter | A.J. Burnett | | 711 | 520 | 191 |
| 2011-08-28 | @ BAL | 130 | L 0-2 | 78-52 | 3 | 28,751 | Bartolo Colon | Zachary Britton | Zachary Britton | Bartolo Colon | Kevin Gregg | 711 | 522 | 189 |
| 2011-08-28 | @ BAL | 131 | W 8-3 | 78-52 | 3 | 37,528 | Ivan Nova | Brian Matusz | Ivan Nova | Brian Matusz | | 719 | 525 | 194 |
| 2011-08-29 | @ BAL | 132 | W 3-2 | 80-52 | 2 | 18,223 | Freddy Garcia | Alfredo Simon | Freddy Garcia | Alfredo Simon | Mariano Rivera | 722 | 527 | 195 |
| 2011-08-30 | @ BOS | 133 | W 5-2 | 81-52 | 2 | 37,773 | CC Sabathia | John Lackey | CC Sabathia | John Lackey | Mariano Rivera | 727 | 529 | 198 |
| 2011-08-31 | @ BOS | 134 | L 5-9 | 81-53 | 2 | 38,021 | Phil Hughes | Josh Beckett | Josh Beckett | Phil Hughes | | 732 | 538 | 194 |
| 2011-09-01 | @ BOS | 135 | W 4-2 | 82-53 | 2 | 38,074 | A.J. Burnett | Jon Lester | Cory Wade | Alfredo Aceves | Mariano Rivera | 736 | 540 | 196 |
| 2011-09-02 | vs TOR | 136 | W 3-2 | 83-53 | 1 | 47,240 | Ivan Nova | Brandon Morrow | Ivan Nova | Brandon Morrow | Mariano Rivera | 739 | 542 | 197 |
| 2011-09-03 | vs TOR | 137 | W 6-4 | 84-53 | 1 | 47,744 | Bartolo Colon | Ricky Romero | Boone Logan | Ricky Romero | David Robertson | 745 | 546 | 199 |
| 2011-09-04 | vs TOR | 138 | W 9-3 | 85-53 | 1 | 47,464 | CC Sabathia | Brett Cecil | CC Sabathia | Brett Cecil | | 754 | 549 | 205 |
| 2011-09-05 | vs BAL | 139 | W 11-10 | 86-53 | 1 | 45,069 | Freddy Garcia | Brian Matusz | Aaron Laffey | Jim Johnson | Mariano Rivera | 765 | 559 | 206 |
| 2011-09-06 | vs BAL | 140 | W 5-3 | 87-53 | 1 | 44,573 | Phil Hughes | Tommy Hunter | Cory Wade | Tommy Hunter | Mariano Rivera | 770 | 562 | 208 |
| 2011-09-07 | vs BAL | 141 | L 4-5 | 87-54 | 1 | 40,104 | A.J. Burnett | Zachary Britton | Pedro Strop | Hector Noesi | Jim Johnson | 774 | 567 | 207 |
| 2011-09-08 | @ BAL | 142 | L 4-5 | 87-55 | 1 | 33,841 | Ivan Nova | Alfredo Simon | Clay Rapada | Scott Proctor | | 778 | 572 | 206 |
| 2011-09-09 | @ ANA | 143 | L 1-2 | 87-56 | 1 | 41,014 | Bartolo Colon | Jered Weaver | Jordan Walden | Aaron Laffey | | 779 | 574 | 205 |
| 2011-09-10 | @ ANA | 144 | L 0-6 | 87-57 | 1 | 42,774 | CC Sabathia | Dan Haren | Dan Haren | CC Sabathia | | 779 | 580 | 199 |
| 2011-09-11 | @ ANA | 145 | W 6-5 | 88-57 | 1 | 42,581 | Freddy Garcia | Ervin Santana | Cory Wade | Ervin Santana | Mariano Rivera | 785 | 585 | 200 |
| 2011-09-12 | @ SEA | 146 | W 9-3 | 89-57 | 1 | 22,029 | Phil Hughes | Felix Hernandez | Phil Hughes | Felix Hernandez | | 794 | 588 | 206 |
| 2011-09-13 | @ SEA | 147 | W 3-2 | 90-57 | 1 | 18,306 | A.J. Burnett | Charlie Furbush | A.J. Burnett | Charlie Furbush | Mariano Rivera | 797 | 590 | 207 |
| 2011-09-14 | @ SEA | 148 | L 1-2 | 90-58 | 1 | 20,327 | Ivan Nova | Jason Vargas | Steve Delabar | Cory Wade | | 798 | 592 | 206 |
| 2011-09-16 | @ TOR | 149 | L 4-5 | 90-59 | 1 | 29,323 | CC Sabathia | Dustin McGowan | Casey Janssen | Boone Logan | | 802 | 597 | 205 |
| 2011-09-17 | @ TOR | 150 | W 7-6 | 91-59 | 1 | 39,288 | Bartolo Colon | Henderson Alvarez | Aaron Laffey | Carlos Villanueva | Mariano Rivera | 809 | 603 | 206 |
| 2011-09-18 | @ TOR | 151 | L 0-3 | 91-60 | 1 | 34,657 | Freddy Garcia | Brandon Morrow | Brandon Morrow | Freddy Garcia | Frank Francisco | 809 | 606 | 203 |
| 2011-09-19 | vs MIN | 152 | W 6-4 | 92-60 | 1 | 40,045 | A.J. Burnett | Scott Diamond | Cory Wade | Scott Diamond | Mariano Rivera | 815 | 610 | 205 |
| 2011-09-20 | vs TBA | 153 | W 5-0 | 93-60 | 1 | 46,944 | Ivan Nova | Wade Davis | Ivan Nova | Wade Davis | | 820 | 610 | 210 |
| 2011-09-21 | vs TBA | 154 | W 4-2 | 94-60 | 2 | 42,755 | Hector Noesi | James Shields | Luis Ayala | James Shields | Mariano Rivera | 824 | 612 | 212 |
| 2011-09-21 | vs TBA | 155 | W 4-2 | 94-60 | 2 | 45,586 | CC Sabathia | Jeremy Hellickson | David Robertson | Jake McGee | Rafael Soriano | 828 | 614 | 214 |
| 2011-09-22 | vs TBA | 156 | L 8-15 | 95-61 | 1 | 47,470 | Bartolo Colon | Matt Moore | Matt Moore | Bartolo Colon | | 836 | 629 | 207 |
| 2011-09-24 | vs BOS | 157 | W 9-1 | 96-61 | 1 | 49,556 | Freddy Garcia | Jon Lester | Freddy Garcia | Jon Lester | | 845 | 630 | 215 |
| 2011-09-25 | vs BOS | 158 | W 6-2 | 97-62 | 2 | 49,541 | A.J. Burnett | Tim Wakefield | A.J. Burnett | Tim Wakefield | | 851 | 632 | 219 |
| 2011-09-25 | vs BOS | 159 | L 4-7 | 97-62 | 2 | 49,072 | Ivan Nova | John Lackey | Franklin Morales | Scott Proctor | Felix Doubront | 855 | 639 | 216 |
| 2011-09-26 | @ TBA | 160 | L 2-5 | 97-63 | 1 | 18,772 | Hector Noesi | James Shields | James Shields | Hector Noesi | Kyle Farnsworth | 857 | 644 | 213 |
| 2011-09-27 | @ TBA | 161 | L 3-5 | 97-64 | 1 | 22,820 | Bartolo Colon | Jeremy Hellickson | Jake McGee | Rafael Soriano | Kyle Farnsworth | 860 | 649 | 211 |
| 2011-09-28 | @ TBA | 162 | L 7-8 | 97-65 | 1 | 29,518 | Dellin Betances | David Price | Jake McGee | Scott Proctor | | 867 | 657 | 210 |