| 2011-04-01 | @ FLO | 1 | L 2-6 | 0-1 | 4 | 41,237 | Mike Pelfrey | Josh Johnson | Josh Johnson | Mike Pelfrey | | 2 | 6 | -4 |
| 2011-04-02 | @ FLO | 2 | W 6-4 | 1-1 | 4 | 32,495 | Jonathon Niese | Ricky Nolasco | Francisco Rodriguez | Ryan Webb | Blaine Boyer | 8 | 10 | -2 |
| 2011-04-03 | @ FLO | 3 | W 9-2 | 2-1 | 3 | 18,936 | R.A. Dickey | Javier Vazquez | R.A. Dickey | Javier Vazquez | | 17 | 12 | 5 |
| 2011-04-05 | @ PHI | 4 | W 7-1 | 3-1 | 1 | 45,365 | Chris Young | Cole Hamels | Chris Young | Cole Hamels | | 24 | 13 | 11 |
| 2011-04-06 | @ PHI | 5 | L 7-10 | 3-2 | 3 | 45,061 | Mike Pelfrey | Joe Blanton | Antonio Bastardo | Blaine Boyer | Jose Contreras | 31 | 23 | 8 |
| 2011-04-07 | @ PHI | 6 | L 0-11 | 3-3 | 3 | 45,468 | Jonathon Niese | Roy Halladay | Roy Halladay | Jonathon Niese | | 31 | 34 | -3 |
| 2011-04-08 | vs WAS | 7 | L 2-6 | 3-4 | 4 | 41,075 | R.A. Dickey | Jordan Zimmermann | Jordan Zimmermann | R.A. Dickey | | 33 | 40 | -7 |
| 2011-04-09 | vs WAS | 8 | W 8-4 | 4-4 | 3 | 31,696 | Chris Capuano | Tom Gorzelanny | Chris Capuano | Tom Gorzelanny | Francisco Rodriguez | 41 | 44 | -3 |
| 2011-04-10 | vs WAS | 9 | L 3-7 | 4-5 | 3 | 35,157 | Chris Young | Jason Marquis | Drew Storen | Blaine Boyer | | 44 | 51 | -7 |
| 2011-04-11 | vs COL | 10 | L 6-7 | 4-6 | 4 | 24,865 | Mike Pelfrey | Jason Hammel | Matt Belisle | Bobby Parnell | Huston Street | 50 | 58 | -8 |
| 2011-04-13 | vs COL | 11 | L 4-5 | 4-7 | 5 | 25,878 | Jonathon Niese | Esmil Rogers | Esmil Rogers | Jonathon Niese | Huston Street | 54 | 63 | -9 |
| 2011-04-14 | vs COL | 12 | L 5-6 | 4-9 | 6 | 0 | R.A. Dickey | Greg Reynolds | Greg Reynolds | R.A. Dickey | Matt Lindstrom | 59 | 69 | -10 |
| 2011-04-14 | vs COL | 13 | L 4-9 | 4-9 | 6 | 25,758 | Chris Capuano | Jorge de la Rosa | Jorge de la Rosa | Chris Capuano | | 63 | 78 | -15 |
| 2011-04-16 | @ ATL | 14 | L 2-4 | 4-11 | 7 | 0 | D.J. Carrasco | Derek Lowe | Derek Lowe | D.J. Carrasco | Craig Kimbrel | 65 | 82 | -17 |
| 2011-04-16 | @ ATL | 15 | L 0-4 | 4-11 | 7 | 31,383 | Mike Pelfrey | Jair Jurrjens | Jair Jurrjens | Mike Pelfrey | | 65 | 86 | -21 |
| 2011-04-17 | @ ATL | 16 | W 3-2 | 5-11 | 6 | 29,625 | Dillon Gee | Tommy Hanson | Dillon Gee | Tommy Hanson | Francisco Rodriguez | 68 | 88 | -20 |
| 2011-04-19 | vs HOU | 17 | L 1-6 | 5-12 | 5 | 27,032 | Jonathon Niese | Wandy Rodriguez | Wandy Rodriguez | Jonathon Niese | | 69 | 94 | -25 |
| 2011-04-20 | vs HOU | 18 | L 3-4 | 5-13 | 6 | 27,380 | R.A. Dickey | Bud Norris | Mark Melancon | R.A. Dickey | Brandon Lyon | 72 | 98 | -26 |
| 2011-04-21 | vs HOU | 19 | W 9-1 | 6-13 | 5 | 32,819 | Chris Capuano | J.A. Happ | Chris Capuano | J.A. Happ | | 81 | 99 | -18 |
| 2011-04-22 | vs ARI | 20 | W 4-1 | 7-13 | 5 | 26,546 | Mike Pelfrey | Joe Saunders | Mike Pelfrey | Esmerling Vasquez | Francisco Rodriguez | 85 | 100 | -15 |
| 2011-04-23 | vs ARI | 21 | W 6-4 | 8-13 | 5 | 25,581 | Dillon Gee | Barry Enright | Dillon Gee | Barry Enright | Francisco Rodriguez | 91 | 104 | -13 |
| 2011-04-24 | vs ARI | 22 | W 8-4 | 9-13 | 5 | 22,232 | Jonathon Niese | Armando Galarraga | Jonathon Niese | Armando Galarraga | | 99 | 108 | -9 |
| 2011-04-26 | @ WAS | 23 | W 6-4 | 10-13 | 5 | 14,603 | Chris Young | Jordan Zimmermann | Ryota Igarashi | Jordan Zimmermann | Francisco Rodriguez | 105 | 112 | -7 |
| 2011-04-27 | @ WAS | 24 | W 6-3 | 11-13 | 4 | 13,568 | R.A. Dickey | Tom Gorzelanny | Pedro Beato | Sean Burnett | Francisco Rodriguez | 111 | 115 | -4 |
| 2011-04-28 | @ WAS | 25 | L 3-4 | 11-14 | 5 | 15,142 | Chris Capuano | Livan Hernandez | Livan Hernandez | Chris Capuano | Drew Storen | 114 | 119 | -5 |
| 2011-04-29 | @ PHI | 26 | L 3-10 | 11-15 | 5 | 45,613 | Mike Pelfrey | Vance Worley | Vance Worley | Mike Pelfrey | | 117 | 129 | -12 |
| 2011-04-30 | @ PHI | 27 | L 1-2 | 11-16 | 5 | 45,598 | Jonathon Niese | Roy Halladay | Roy Halladay | Jonathon Niese | | 118 | 131 | -13 |
| 2011-05-01 | @ PHI | 28 | W 2-1 | 12-16 | 5 | 45,713 | Chris Young | Cliff Lee | Taylor Buchholz | Kyle Kendrick | | 120 | 132 | -12 |
| 2011-05-03 | vs SFN | 29 | L 6-7 | 12-17 | 5 | 32,288 | R.A. Dickey | Ryan Vogelsong | Javier Lopez | Taylor Buchholz | Brian Wilson | 126 | 139 | -13 |
| 2011-05-04 | vs SFN | 30 | L 0-2 | 12-18 | 6 | 29,333 | Chris Capuano | Tim Lincecum | Tim Lincecum | Chris Capuano | Brian Wilson | 126 | 141 | -15 |
| 2011-05-05 | vs SFN | 31 | W 5-2 | 13-18 | 5 | 23,433 | Mike Pelfrey | Jonathan Sanchez | Mike Pelfrey | Jonathan Sanchez | Francisco Rodriguez | 131 | 143 | -12 |
| 2011-05-06 | vs LAN | 32 | W 6-3 | 14-18 | 5 | 35,948 | Jonathon Niese | Hiroki Kuroda | Ryota Igarashi | Hiroki Kuroda | Francisco Rodriguez | 137 | 146 | -9 |
| 2011-05-07 | vs LAN | 33 | W 4-2 | 15-18 | 5 | 31,464 | Dillon Gee | Jon Garland | Tim Byrdak | Mike MacDougal | Francisco Rodriguez | 141 | 148 | -7 |
| 2011-05-08 | vs LAN | 34 | L 2-4 | 15-19 | 5 | 26,312 | R.A. Dickey | Clayton Kershaw | Clayton Kershaw | R.A. Dickey | Vicente Padilla | 143 | 152 | -9 |
| 2011-05-09 | @ COL | 35 | L 1-2 | 15-20 | 5 | 31,885 | Chris Capuano | Jhoulis Chacin | Matt Belisle | Chris Capuano | Huston Street | 144 | 154 | -10 |
| 2011-05-10 | @ COL | 36 | W 4-3 | 16-20 | 5 | 31,007 | Mike Pelfrey | Jason Hammel | Mike Pelfrey | Jason Hammel | Francisco Rodriguez | 148 | 157 | -9 |
| 2011-05-12 | @ COL | 37 | W 9-5 | 17-20 | 5 | 21,422 | Jonathon Niese | Ubaldo Jimenez | Jonathon Niese | Ubaldo Jimenez | | 157 | 162 | -5 |
| 2011-05-13 | @ HOU | 38 | W 6-4 | 18-20 | 4 | 28,791 | Dillon Gee | Bud Norris | Pat Misch | Jeff Fulchino | Francisco Rodriguez | 163 | 166 | -3 |
| 2011-05-14 | @ HOU | 39 | L 3-7 | 18-21 | 4 | 31,140 | R.A. Dickey | J.A. Happ | J.A. Happ | R.A. Dickey | | 166 | 173 | -7 |
| 2011-05-15 | @ HOU | 40 | W 7-4 | 19-21 | 4 | 28,406 | Chris Capuano | Aneury Rodriguez | Chris Capuano | Aneury Rodriguez | Francisco Rodriguez | 173 | 177 | -4 |
| 2011-05-16 | vs FLO | 41 | L 1-2 | 19-22 | 5 | 23,721 | Mike Pelfrey | Josh Johnson | Burke Badenhop | Ryota Igarashi | Leo Nunez | 174 | 179 | -5 |
| 2011-05-18 | vs WAS | 42 | W 3-0 | 20-22 | 4 | 24,527 | Jonathon Niese | Tom Gorzelanny | Jonathon Niese | Tom Gorzelanny | Francisco Rodriguez | 177 | 179 | -2 |
| 2011-05-19 | vs WAS | 43 | W 1-0 | 21-22 | 4 | 26,835 | Dillon Gee | Livan Hernandez | Dillon Gee | Livan Hernandez | Francisco Rodriguez | 178 | 179 | -1 |
| 2011-05-20 | @ NYA | 44 | W 2-1 | 22-22 | 4 | 47,874 | R.A. Dickey | Freddy Garcia | R.A. Dickey | Freddy Garcia | Francisco Rodriguez | 180 | 180 | 0 |
| 2011-05-21 | @ NYA | 45 | L 3-7 | 22-23 | 4 | 48,286 | Chris Capuano | A.J. Burnett | A.J. Burnett | Chris Capuano | | 183 | 187 | -4 |
| 2011-05-22 | @ NYA | 46 | L 3-9 | 22-24 | 4 | 48,293 | Mike Pelfrey | Ivan Nova | Luis Ayala | Mike Pelfrey | | 186 | 196 | -10 |
| 2011-05-24 | @ CHN | 47 | L 1-11 | 22-25 | 4 | 35,707 | Jonathon Niese | Ryan Dempster | Ryan Dempster | Jonathon Niese | | 187 | 207 | -20 |
| 2011-05-25 | @ CHN | 48 | W 7-4 | 23-25 | 4 | 36,666 | Dillon Gee | Casey Coleman | Dillon Gee | Casey Coleman | | 194 | 211 | -17 |
| 2011-05-26 | @ CHN | 49 | L 3-9 | 23-26 | 4 | 33,378 | R.A. Dickey | Carlos Zambrano | Carlos Zambrano | Pedro Beato | | 197 | 220 | -23 |
| 2011-05-27 | vs PHI | 50 | L 4-6 | 23-27 | 4 | 33,882 | Chris Capuano | Roy Oswalt | Antonio Bastardo | Francisco Rodriguez | Ryan Madson | 201 | 226 | -25 |
| 2011-05-28 | vs PHI | 51 | L 2-5 | 23-28 | 4 | 29,337 | Mike Pelfrey | Cole Hamels | Cole Hamels | Mike O'Connor | Ryan Madson | 203 | 231 | -28 |
| 2011-05-29 | vs PHI | 52 | W 9-5 | 24-28 | 4 | 30,791 | Jonathon Niese | Vance Worley | Jonathon Niese | Vance Worley | | 212 | 236 | -24 |
| 2011-05-30 | vs PIT | 53 | W 7-3 | 25-28 | 4 | 24,490 | Dillon Gee | Charlie Morton | Dillon Gee | Daniel McCutchen | | 219 | 239 | -20 |
| 2011-05-31 | vs PIT | 54 | L 1-5 | 25-29 | 4 | 26,198 | R.A. Dickey | James McDonald | Evan Meek | R.A. Dickey | | 220 | 244 | -24 |
| 2011-06-01 | vs PIT | 55 | L 3-9 | 25-30 | 4 | 25,234 | Chris Capuano | Kevin Correia | Kevin Correia | Chris Capuano | | 223 | 253 | -30 |
| 2011-06-02 | vs PIT | 56 | W 9-8 | 26-30 | 4 | 30,074 | Mike Pelfrey | Paul Maholm | Jason Isringhausen | Jose Veras | Francisco Rodriguez | 232 | 261 | -29 |
| 2011-06-03 | vs ATL | 57 | L 3-6 | 26-31 | 4 | 28,301 | Jonathon Niese | Derek Lowe | Jonny Venters | Francisco Rodriguez | Craig Kimbrel | 235 | 267 | -32 |
| 2011-06-04 | vs ATL | 58 | W 5-0 | 27-31 | 4 | 28,114 | Dillon Gee | Jair Jurrjens | Dillon Gee | Jair Jurrjens | | 240 | 267 | -27 |
| 2011-06-05 | vs ATL | 59 | W 6-4 | 28-31 | 4 | 21,015 | R.A. Dickey | Tim Hudson | R.A. Dickey | Tim Hudson | | 246 | 271 | -25 |
| 2011-06-07 | @ MIL | 60 | W 2-1 | 29-31 | 4 | 27,064 | Chris Capuano | Shaun Marcum | Chris Capuano | Marco Estrada | Francisco Rodriguez | 248 | 272 | -24 |
| 2011-06-08 | @ MIL | 61 | L 6-7 | 29-32 | 4 | 26,114 | Mike Pelfrey | Randy Wolf | John Axford | Dale Thayer | | 254 | 279 | -25 |
| 2011-06-09 | @ MIL | 62 | W 4-1 | 30-32 | 4 | 30,632 | Jonathon Niese | Yovani Gallardo | Jonathon Niese | Yovani Gallardo | Francisco Rodriguez | 258 | 280 | -22 |
| 2011-06-10 | @ PIT | 63 | W 8-1 | 31-32 | 4 | 24,653 | Dillon Gee | Charlie Morton | Dillon Gee | Charlie Morton | | 266 | 281 | -15 |
| 2011-06-11 | @ PIT | 64 | L 2-3 | 31-33 | 4 | 39,273 | R.A. Dickey | James McDonald | James McDonald | R.A. Dickey | Joel Hanrahan | 268 | 284 | -16 |
| 2011-06-12 | @ PIT | 65 | W 7-0 | 32-33 | 4 | 26,452 | Chris Capuano | Kevin Correia | Chris Capuano | Kevin Correia | | 275 | 284 | -9 |
| 2011-06-13 | @ PIT | 66 | L 1-3 | 32-34 | 4 | 15,555 | Mike Pelfrey | Paul Maholm | Paul Maholm | Mike Pelfrey | Joel Hanrahan | 276 | 287 | -11 |
| 2011-06-14 | @ ATL | 67 | W 4-3 | 33-34 | 3 | 32,161 | Jonathon Niese | Jair Jurrjens | Jonathon Niese | Jair Jurrjens | Francisco Rodriguez | 280 | 290 | -10 |
| 2011-06-15 | @ ATL | 68 | W 4-0 | 34-34 | 4 | 31,161 | Dillon Gee | Tim Hudson | Bobby Parnell | Tim Hudson | | 284 | 290 | -6 |
| 2011-06-16 | @ ATL | 69 | L 8-9 | 34-35 | 3 | 26,077 | R.A. Dickey | Mike Minor | Scott Linebrink | D.J. Carrasco | | 292 | 299 | -7 |
| 2011-06-17 | vs ANA | 70 | L 3-4 | 34-36 | 3 | 29,513 | Chris Capuano | Joel Pineiro | Joel Pineiro | Chris Capuano | Jordan Walden | 295 | 303 | -8 |
| 2011-06-18 | vs ANA | 71 | W 6-1 | 35-36 | 3 | 31,538 | Mike Pelfrey | Dan Haren | Mike Pelfrey | Dan Haren | | 301 | 304 | -3 |
| 2011-06-19 | vs ANA | 72 | L 3-7 | 35-37 | 3 | 36,213 | Jonathon Niese | Tyler Chatwood | Tyler Chatwood | Jonathon Niese | | 304 | 311 | -7 |
| 2011-06-21 | vs OAK | 73 | L 3-7 | 35-38 | 4 | 37,019 | Dillon Gee | Josh Outman | Josh Outman | Dillon Gee | Grant Balfour | 307 | 318 | -11 |
| 2011-06-22 | vs OAK | 74 | W 3-2 | 36-38 | 4 | 38,813 | R.A. Dickey | Gio Gonzalez | Bobby Parnell | Brad Ziegler | | 310 | 320 | -10 |
| 2011-06-23 | vs OAK | 75 | W 4-1 | 37-38 | 4 | 30,168 | Chris Capuano | Graham Godfrey | Chris Capuano | Graham Godfrey | Francisco Rodriguez | 314 | 321 | -7 |
| 2011-06-24 | @ TEX | 76 | L 1-8 | 37-39 | 4 | 46,092 | Mike Pelfrey | Matt Harrison | Matt Harrison | Mike Pelfrey | | 315 | 329 | -14 |
| 2011-06-25 | @ TEX | 77 | W 14-5 | 38-39 | 4 | 37,292 | Jonathon Niese | Alexi Ogando | Jonathon Niese | Alexi Ogando | | 329 | 334 | -5 |
| 2011-06-26 | @ TEX | 78 | W 8-5 | 39-39 | 4 | 37,879 | Dillon Gee | Derek Holland | Dillon Gee | Derek Holland | | 337 | 339 | -2 |
| 2011-06-28 | @ DET | 79 | W 14-3 | 40-39 | 3 | 28,480 | R.A. Dickey | Rick Porcello | R.A. Dickey | Rick Porcello | | 351 | 342 | 9 |
| 2011-06-29 | @ DET | 80 | W 16-9 | 41-39 | 3 | 26,338 | Chris Capuano | Phil Coke | Chris Capuano | Phil Coke | | 367 | 351 | 16 |
| 2011-06-30 | @ DET | 81 | L 2-5 | 41-40 | 3 | 31,861 | Mike Pelfrey | Justin Verlander | Justin Verlander | Mike Pelfrey | Jose Valverde | 369 | 356 | 13 |
| 2011-07-01 | vs NYA | 82 | L 1-5 | 41-41 | 3 | 42,020 | Jonathon Niese | Ivan Nova | Ivan Nova | Jonathon Niese | | 370 | 361 | 9 |
| 2011-07-02 | vs NYA | 83 | L 2-5 | 41-42 | 4 | 42,042 | Dillon Gee | Bartolo Colon | Bartolo Colon | Dillon Gee | | 372 | 366 | 6 |
| 2011-07-03 | vs NYA | 84 | W 3-2 | 42-42 | 3 | 41,513 | R.A. Dickey | Freddy Garcia | Francisco Rodriguez | Luis Ayala | | 375 | 368 | 7 |
| 2011-07-04 | @ LAN | 85 | W 5-2 | 43-42 | 3 | 56,000 | Chris Capuano | Rubby de la Rosa | Chris Capuano | Rubby de la Rosa | Francisco Rodriguez | 380 | 370 | 10 |
| 2011-07-05 | @ LAN | 86 | W 6-0 | 44-42 | 3 | 32,329 | Mike Pelfrey | Ted Lilly | Mike Pelfrey | Ted Lilly | | 386 | 370 | 16 |
| 2011-07-06 | @ LAN | 87 | W 5-3 | 45-42 | 3 | 31,005 | Jonathon Niese | Hiroki Kuroda | Jonathon Niese | Hiroki Kuroda | Francisco Rodriguez | 391 | 373 | 18 |
| 2011-07-07 | @ LAN | 88 | L 0-6 | 45-43 | 3 | 56,000 | Dillon Gee | Clayton Kershaw | Clayton Kershaw | Dillon Gee | | 391 | 379 | 12 |
| 2011-07-08 | @ SFN | 89 | W 5-2 | 46-43 | 3 | 41,028 | R.A. Dickey | Ryan Vogelsong | Pedro Beato | Brian Wilson | Francisco Rodriguez | 396 | 381 | 15 |
| 2011-07-09 | @ SFN | 90 | L 1-3 | 46-44 | 3 | 42,117 | Chris Capuano | Tim Lincecum | Tim Lincecum | Chris Capuano | Sergio Romo | 397 | 384 | 13 |
| 2011-07-10 | @ SFN | 91 | L 2-4 | 46-45 | 3 | 42,123 | Mike Pelfrey | Matt Cain | Matt Cain | Mike Pelfrey | Brian Wilson | 399 | 388 | 11 |
| 2011-07-15 | vs PHI | 92 | L 2-7 | 46-46 | 3 | 37,304 | R.A. Dickey | Vance Worley | Vance Worley | R.A. Dickey | | 401 | 395 | 6 |
| 2011-07-16 | vs PHI | 93 | W 11-2 | 47-46 | 3 | 41,166 | Jonathon Niese | Cole Hamels | Jonathon Niese | Cole Hamels | | 412 | 397 | 15 |
| 2011-07-17 | vs PHI | 94 | L 5-8 | 47-47 | 3 | 34,695 | Mike Pelfrey | Kyle Kendrick | Kyle Kendrick | Mike Pelfrey | Antonio Bastardo | 417 | 405 | 12 |
| 2011-07-18 | vs FLO | 95 | L 1-4 | 47-48 | 4 | 32,411 | Chris Capuano | Clay Hensley | Clay Hensley | Chris Capuano | Leo Nunez | 418 | 409 | 9 |
| 2011-07-19 | vs SLN | 96 | W 4-2 | 48-48 | 3 | 35,448 | Dillon Gee | Kyle Lohse | Dillon Gee | Kyle Lohse | Jason Isringhausen | 422 | 411 | 11 |
| 2011-07-20 | vs SLN | 97 | W 6-5 | 49-48 | 3 | 30,770 | R.A. Dickey | Kyle McClellan | Jason Isringhausen | Fernando Salas | | 428 | 416 | 12 |
| 2011-07-21 | vs SLN | 98 | L 2-6 | 49-49 | 3 | 37,416 | Jonathon Niese | Jake Westbrook | Jake Westbrook | Jonathon Niese | | 430 | 422 | 8 |
| 2011-07-22 | @ FLO | 99 | W 7-6 | 50-49 | 3 | 21,304 | Mike Pelfrey | Chris Volstad | Bobby Parnell | Edward Mujica | Jason Isringhausen | 437 | 428 | 9 |
| 2011-07-23 | @ FLO | 100 | L 5-8 | 50-50 | 3 | 26,345 | Chris Capuano | Clay Hensley | Burke Badenhop | Chris Capuano | | 442 | 436 | 6 |
| 2011-07-24 | @ FLO | 101 | L 4-5 | 50-51 | 3 | 20,416 | Dillon Gee | Anibal Sanchez | Randy Choate | Bobby Parnell | Leo Nunez | 446 | 441 | 5 |
| 2011-07-25 | @ CIN | 102 | W 4-2 | 51-51 | 3 | 25,480 | R.A. Dickey | Mike Leake | R.A. Dickey | Mike Leake | Jason Isringhausen | 450 | 443 | 7 |
| 2011-07-26 | @ CIN | 103 | W 8-6 | 52-51 | 3 | 27,552 | Jonathon Niese | Johnny Cueto | Jonathon Niese | Johnny Cueto | Tim Byrdak | 458 | 449 | 9 |
| 2011-07-27 | @ CIN | 104 | W 8-2 | 53-51 | 3 | 23,616 | Mike Pelfrey | Bronson Arroyo | Mike Pelfrey | Bronson Arroyo | | 466 | 451 | 15 |
| 2011-07-28 | @ CIN | 105 | W 10-9 | 54-51 | 3 | 25,400 | Chris Capuano | Homer Bailey | Chris Capuano | Homer Bailey | Jason Isringhausen | 476 | 460 | 16 |
| 2011-07-29 | @ WAS | 106 | W 8-5 | 55-51 | 3 | 30,114 | Dillon Gee | Chien-Ming Wang | Dillon Gee | Chien-Ming Wang | Jason Isringhausen | 484 | 465 | 19 |
| 2011-07-30 | @ WAS | 107 | L 0-3 | 55-52 | 3 | 35,414 | R.A. Dickey | Yuniesky Maya | Yuniesky Maya | R.A. Dickey | Drew Storen | 484 | 468 | 16 |
| 2011-07-31 | @ WAS | 108 | L 2-3 | 55-53 | 3 | 25,307 | Jonathon Niese | Jordan Zimmermann | Drew Storen | Bobby Parnell | | 486 | 471 | 15 |
| 2011-08-01 | vs FLO | 109 | L 3-7 | 55-54 | 3 | 28,862 | Mike Pelfrey | Javier Vazquez | Leo Nunez | Jason Isringhausen | | 489 | 478 | 11 |
| 2011-08-02 | vs FLO | 110 | L 3-4 | 55-55 | 4 | 33,297 | Chris Capuano | Brad Hand | Steve Cishek | Jason Isringhausen | Leo Nunez | 492 | 482 | 10 |
| 2011-08-05 | vs ATL | 111 | L 1-4 | 55-56 | 3 | 30,607 | R.A. Dickey | Tim Hudson | Tim Hudson | R.A. Dickey | Craig Kimbrel | 493 | 486 | 7 |
| 2011-08-06 | vs ATL | 112 | W 11-7 | 56-56 | 3 | 33,556 | Jonathon Niese | Tommy Hanson | Jonathon Niese | Tommy Hanson | | 504 | 493 | 11 |
| 2011-08-07 | vs ATL | 113 | L 5-6 | 56-57 | 3 | 29,853 | Dillon Gee | Mike Minor | Jonny Venters | Bobby Parnell | Craig Kimbrel | 509 | 499 | 10 |
| 2011-08-08 | vs SDN | 114 | W 9-8 | 57-57 | 3 | 21,814 | Mike Pelfrey | Tim Stauffer | Jason Isringhausen | Heath Bell | | 518 | 507 | 11 |
| 2011-08-09 | vs SDN | 115 | W 5-4 | 58-57 | 3 | 24,619 | Chris Capuano | Wade LeBlanc | D.J. Carrasco | Chad Qualls | Jason Isringhausen | 523 | 511 | 12 |
| 2011-08-10 | vs SDN | 116 | L 5-9 | 58-58 | 3 | 39,589 | R.A. Dickey | Aaron Harang | Aaron Harang | R.A. Dickey | | 528 | 520 | 8 |
| 2011-08-11 | vs SDN | 117 | L 2-3 | 58-59 | 3 | 32,348 | Jonathon Niese | Cory Luebke | Chad Qualls | Jonathon Niese | Heath Bell | 530 | 523 | 7 |
| 2011-08-12 | @ ARI | 118 | L 3-4 | 58-60 | 3 | 25,701 | Dillon Gee | Ian Kennedy | Ian Kennedy | Dillon Gee | J.J. Putz | 533 | 527 | 6 |
| 2011-08-13 | @ ARI | 119 | L 4-6 | 58-61 | 3 | 33,552 | Mike Pelfrey | Daniel Hudson | Daniel Hudson | D.J. Carrasco | J.J. Putz | 537 | 533 | 4 |
| 2011-08-14 | @ ARI | 120 | L 3-5 | 58-62 | 3 | 30,148 | Chris Capuano | Jason Marquis | Zach Duke | Chris Capuano | David Hernandez | 540 | 538 | 2 |
| 2011-08-15 | @ SDN | 121 | W 5-4 | 59-62 | 3 | 30,094 | R.A. Dickey | Aaron Harang | Manny Acosta | Josh Spence | Jason Isringhausen | 545 | 542 | 3 |
| 2011-08-16 | @ SDN | 122 | L 1-6 | 59-63 | 3 | 24,212 | Jonathon Niese | Cory Luebke | Cory Luebke | Jonathon Niese | | 546 | 548 | -2 |
| 2011-08-17 | @ SDN | 123 | W 7-3 | 60-63 | 3 | 22,089 | Dillon Gee | Mat Latos | Dillon Gee | Mat Latos | | 553 | 551 | 2 |
| 2011-08-19 | vs MIL | 124 | L 1-6 | 60-64 | 4 | 24,470 | Mike Pelfrey | Shaun Marcum | Shaun Marcum | Mike Pelfrey | | 554 | 557 | -3 |
| 2011-08-20 | vs MIL | 125 | L 9-11 | 60-65 | 4 | 28,234 | Chris Capuano | Randy Wolf | Francisco Rodriguez | Jason Isringhausen | John Axford | 563 | 568 | -5 |
| 2011-08-21 | vs MIL | 126 | L 2-6 | 60-66 | 4 | 25,949 | R.A. Dickey | Yovani Gallardo | Yovani Gallardo | Manny Acosta | | 565 | 574 | -9 |
| 2011-08-22 | @ PHI | 127 | L 0-10 | 60-67 | 4 | 45,783 | Dillon Gee | Cliff Lee | Cliff Lee | Dillon Gee | | 565 | 584 | -19 |
| 2011-08-23 | @ PHI | 128 | L 4-9 | 60-68 | 4 | 45,770 | Jonathon Niese | Vance Worley | Vance Worley | Jonathon Niese | | 569 | 593 | -24 |
| 2011-08-24 | @ PHI | 129 | W 7-4 | 61-68 | 4 | 45,689 | Mike Pelfrey | Kyle Kendrick | Mike Pelfrey | Kyle Kendrick | Bobby Parnell | 576 | 597 | -21 |
| 2011-08-26 | vs ATL | 130 | W 6-0 | 62-68 | 3 | 22,736 | Chris Capuano | Tim Hudson | Chris Capuano | Tim Hudson | | 582 | 597 | -15 |
| 2011-08-29 | vs FLO | 131 | W 2-1 | 63-68 | 4 | 0 | R.A. Dickey | Anibal Sanchez | R.A. Dickey | Anibal Sanchez | Bobby Parnell | 584 | 598 | -14 |
| 2011-08-29 | vs FLO | 132 | W 5-1 | 63-68 | 4 | 29,335 | Dillon Gee | Ricky Nolasco | Dillon Gee | Ricky Nolasco | | 589 | 599 | -10 |
| 2011-08-30 | vs FLO | 133 | L 0-6 | 64-69 | 3 | 30,806 | Mike Pelfrey | Javier Vazquez | Javier Vazquez | Mike Pelfrey | | 589 | 605 | -16 |
| 2011-08-31 | vs FLO | 134 | W 3-2 | 65-69 | 3 | 27,905 | Chris Capuano | Chris Volstad | Manny Acosta | Chris Volstad | Bobby Parnell | 592 | 607 | -15 |
| 2011-09-01 | vs FLO | 135 | W 7-5 | 66-69 | 3 | 27,562 | Miguel Batista | Clay Hensley | Miguel Batista | Clay Hensley | Bobby Parnell | 599 | 612 | -13 |
| 2011-09-02 | @ WAS | 136 | W 7-3 | 67-69 | 3 | 27,907 | R.A. Dickey | Ross Detwiler | R.A. Dickey | Ross Detwiler | | 606 | 615 | -9 |
| 2011-09-03 | @ WAS | 137 | L 7-8 | 67-70 | 3 | 34,821 | Dillon Gee | Tom Milone | Sean Burnett | Bobby Parnell | | 613 | 623 | -10 |
| 2011-09-04 | @ WAS | 138 | W 6-3 | 68-70 | 3 | 29,679 | Mike Pelfrey | Livan Hernandez | Ryota Igarashi | Livan Hernandez | Bobby Parnell | 619 | 626 | -7 |
| 2011-09-05 | @ FLO | 139 | L 3-9 | 68-71 | 3 | 21,112 | Chris Capuano | Javier Vazquez | Javier Vazquez | Chris Capuano | | 622 | 635 | -13 |
| 2011-09-06 | @ FLO | 140 | W 7-4 | 69-71 | 3 | 22,318 | Miguel Batista | Chris Volstad | Ryota Igarashi | Jose Ceda | Josh Stinson | 629 | 639 | -10 |
| 2011-09-07 | @ FLO | 141 | W 1-0 | 70-71 | 3 | 21,303 | R.A. Dickey | Brad Hand | R.A. Dickey | Brad Hand | Manny Acosta | 630 | 639 | -9 |
| 2011-09-08 | vs ATL | 142 | L 5-6 | 70-73 | 5 | 0 | Chris Schwinden | Mike Minor | Mike Minor | Chris Schwinden | Craig Kimbrel | 635 | 645 | -10 |
| 2011-09-08 | vs ATL | 143 | L 1-5 | 70-73 | 5 | 25,953 | Dillon Gee | Julio Teheran | Julio Teheran | Dillon Gee | | 636 | 650 | -14 |
| 2011-09-09 | vs CHN | 144 | W 5-4 | 71-73 | 3 | 27,639 | Mike Pelfrey | Casey Coleman | Manny Acosta | Sean Marshall | | 641 | 654 | -13 |
| 2011-09-10 | vs CHN | 145 | L 4-5 | 71-74 | 3 | 30,443 | Chris Capuano | Randy Wells | Kerry Wood | Bobby Parnell | Carlos Marmol | 645 | 659 | -14 |
| 2011-09-11 | vs CHN | 146 | L 6-10 | 71-75 | 3 | 33,502 | Miguel Batista | Matt Garza | Ramon Ortiz | Josh Stinson | | 651 | 669 | -18 |
| 2011-09-12 | vs WAS | 147 | L 2-3 | 71-76 | 3 | 27,015 | R.A. Dickey | Ross Detwiler | Todd Coffey | R.A. Dickey | Drew Storen | 653 | 672 | -19 |
| 2011-09-13 | vs WAS | 148 | L 2-3 | 71-77 | 3 | 25,359 | Dillon Gee | Chien-Ming Wang | Craig Stammen | Dale Thayer | Drew Storen | 655 | 675 | -20 |
| 2011-09-14 | vs WAS | 149 | L 0-2 | 71-78 | 3 | 26,885 | Mike Pelfrey | Brad Peacock | Brad Peacock | Mike Pelfrey | Drew Storen | 655 | 677 | -22 |
| 2011-09-15 | vs WAS | 150 | L 1-10 | 71-79 | 5 | 22,205 | Chris Schwinden | Tom Milone | Tom Milone | Chris Schwinden | | 656 | 687 | -31 |
| 2011-09-16 | @ ATL | 151 | W 12-2 | 72-79 | 3 | 43,901 | Chris Capuano | Derek Lowe | Chris Capuano | Derek Lowe | | 668 | 689 | -21 |
| 2011-09-17 | @ ATL | 152 | L 0-1 | 72-80 | 3 | 46,763 | R.A. Dickey | Tim Hudson | Tim Hudson | R.A. Dickey | Craig Kimbrel | 668 | 690 | -22 |
| 2011-09-18 | @ ATL | 153 | W 7-5 | 73-80 | 3 | 39,862 | Dillon Gee | Brandon Beachy | Tim Byrdak | Jonny Venters | Manny Acosta | 675 | 695 | -20 |
| 2011-09-20 | @ SLN | 154 | L 6-11 | 73-81 | 6 | 37,746 | Mike Pelfrey | Edwin Jackson | Octavio Dotel | Josh Stinson | | 681 | 706 | -25 |
| 2011-09-21 | @ SLN | 155 | L 5-6 | 73-82 | 4 | 40,658 | Chris Schwinden | Jaime Garcia | Jaime Garcia | Danny Herrera | Jason Motte | 686 | 712 | -26 |
| 2011-09-22 | @ SLN | 156 | W 8-6 | 74-82 | 4 | 35,992 | Chris Capuano | Jake Westbrook | Manny Acosta | Marc Rzepczynski | Bobby Parnell | 694 | 718 | -24 |
| 2011-09-24 | vs PHI | 157 | W 2-1 | 75-82 | 6 | 33,961 | R.A. Dickey | Cole Hamels | Bobby Parnell | Brad Lidge | Manny Acosta | 696 | 719 | -23 |
| 2011-09-24 | vs PHI | 158 | W 6-3 | 75-82 | 6 | 32,437 | Dillon Gee | Joe Blanton | Dillon Gee | David Herndon | Manny Acosta | 702 | 722 | -20 |
| 2011-09-25 | vs PHI | 159 | L 4-9 | 76-83 | 4 | 32,796 | Mike Pelfrey | Roy Halladay | Roy Halladay | Mike Pelfrey | | 706 | 731 | -25 |
| 2011-09-26 | vs CIN | 160 | L 5-6 | 76-84 | 4 | 28,651 | Chris Schwinden | Homer Bailey | Logan Ondrusek | Tim Byrdak | Francisco Cordero | 711 | 737 | -26 |
| 2011-09-27 | vs CIN | 161 | L 4-5 | 76-85 | 4 | 30,027 | Chris Capuano | Bronson Arroyo | Sam LeCure | Dale Thayer | Francisco Cordero | 715 | 742 | -27 |
| 2011-09-28 | vs CIN | 162 | W 3-0 | 77-85 | 4 | 28,816 | Miguel Batista | Edinson Volquez | Miguel Batista | Edinson Volquez | | 718 | 742 | -24 |