| 2011-04-01 | @ TOR | 1 | L 3-13 | 0-1 | 4 | 47,984 | Carl Pavano | Ricky Romero | Ricky Romero | Carl Pavano | | 3 | 13 | -10 |
| 2011-04-02 | @ TOR | 2 | L 1-6 | 0-2 | 5 | 27,194 | Francisco Liriano | Kyle Drabek | Kyle Drabek | Francisco Liriano | | 4 | 19 | -15 |
| 2011-04-03 | @ TOR | 3 | W 4-3 | 1-2 | 5 | 35,505 | Nick Blackburn | Brett Cecil | Nick Blackburn | Brett Cecil | Joe Nathan | 8 | 22 | -14 |
| 2011-04-04 | @ NYA | 4 | L 3-4 | 1-3 | 5 | 40,311 | Scott Baker | Ivan Nova | Ivan Nova | Scott Baker | Mariano Rivera | 11 | 26 | -15 |
| 2011-04-05 | @ NYA | 5 | W 5-4 | 2-3 | 4 | 40,267 | Brian Duensing | CC Sabathia | Matt Capps | Boone Logan | Joe Nathan | 16 | 30 | -14 |
| 2011-04-07 | @ NYA | 6 | L 3-4 | 2-4 | 5 | 41,512 | Francisco Liriano | A.J. Burnett | A.J. Burnett | Francisco Liriano | Mariano Rivera | 19 | 34 | -15 |
| 2011-04-08 | vs OAK | 7 | W 2-1 | 3-4 | 5 | 40,714 | Carl Pavano | Brett Anderson | Carl Pavano | Brett Anderson | Joe Nathan | 21 | 35 | -14 |
| 2011-04-09 | vs OAK | 8 | L 0-1 | 3-5 | 5 | 39,936 | Nick Blackburn | Gio Gonzalez | Gio Gonzalez | Nick Blackburn | Brian Fuentes | 21 | 36 | -15 |
| 2011-04-10 | vs OAK | 9 | L 3-5 | 3-6 | 5 | 38,484 | Scott Baker | Brandon McCarthy | Brandon McCarthy | Scott Baker | Brian Fuentes | 24 | 41 | -17 |
| 2011-04-12 | vs KCA | 10 | W 4-3 | 4-6 | 4 | 38,154 | Brian Duensing | Jeff Francis | Dusty Hughes | Rob Tejeda | | 28 | 44 | -16 |
| 2011-04-13 | vs KCA | 11 | L 5-10 | 4-7 | 5 | 36,286 | Francisco Liriano | Kyle Davies | Kyle Davies | Francisco Liriano | Jeremy Jeffress | 33 | 54 | -21 |
| 2011-04-14 | @ TBA | 12 | L 3-4 | 4-8 | 5 | 10,042 | Carl Pavano | James Shields | Kyle Farnsworth | Matt Capps | | 36 | 58 | -22 |
| 2011-04-15 | @ TBA | 13 | L 2-5 | 4-9 | 5 | 15,342 | Nick Blackburn | Wade Davis | Wade Davis | Nick Blackburn | Kyle Farnsworth | 38 | 63 | -25 |
| 2011-04-16 | @ TBA | 14 | L 3-4 | 4-10 | 5 | 16,428 | Scott Baker | Jeff Niemann | Juan Cruz | Joe Nathan | | 41 | 67 | -26 |
| 2011-04-17 | @ TBA | 15 | W 4-2 | 5-10 | 5 | 22,426 | Brian Duensing | Jeremy Hellickson | Brian Duensing | Jeremy Hellickson | Matt Capps | 45 | 69 | -24 |
| 2011-04-18 | @ BAL | 16 | W 5-3 | 6-10 | 5 | 13,138 | Francisco Liriano | Chris Tillman | Francisco Liriano | Chris Tillman | Matt Capps | 50 | 72 | -22 |
| 2011-04-19 | @ BAL | 17 | L 0-11 | 6-11 | 5 | 12,045 | Carl Pavano | Jake Arrieta | Jake Arrieta | Carl Pavano | | 50 | 83 | -33 |
| 2011-04-20 | @ BAL | 18 | L 4-5 | 6-12 | 5 | 13,825 | Nick Blackburn | Zachary Britton | Zachary Britton | Nick Blackburn | Kevin Gregg | 54 | 88 | -34 |
| 2011-04-21 | @ BAL | 19 | W 3-1 | 7-12 | 5 | 16,769 | Scott Baker | Jeremy Guthrie | Scott Baker | Jeremy Guthrie | Matt Capps | 57 | 89 | -32 |
| 2011-04-23 | vs CLE | 20 | W 10-3 | 8-12 | 4 | 39,459 | Brian Duensing | Fausto Carmona | Brian Duensing | Fausto Carmona | | 67 | 92 | -25 |
| 2011-04-24 | vs CLE | 21 | W 4-3 | 9-12 | 4 | 39,388 | Carl Pavano | Carlos Carrasco | Carl Pavano | Rafael Perez | Matt Capps | 71 | 95 | -24 |
| 2011-04-27 | vs TBA | 22 | L 2-8 | 9-13 | 4 | 36,714 | Francisco Liriano | Wade Davis | Wade Davis | Francisco Liriano | | 73 | 103 | -30 |
| 2011-04-28 | vs TBA | 23 | L 3-15 | 9-15 | 6 | 38,215 | Nick Blackburn | Jeremy Hellickson | Jeremy Hellickson | Nick Blackburn | | 76 | 118 | -42 |
| 2011-04-28 | vs TBA | 24 | L 1-6 | 9-15 | 6 | 36,456 | Anthony Swarzak | Jeff Niemann | Jeff Niemann | Anthony Swarzak | | 77 | 124 | -47 |
| 2011-04-29 | @ KCA | 25 | L 3-4 | 9-16 | 5 | 31,407 | Scott Baker | Bruce Chen | Blake Wood | Alex Burnett | Joakim Soria | 80 | 128 | -48 |
| 2011-04-30 | @ KCA | 26 | L 2-11 | 9-17 | 5 | 22,099 | Brian Duensing | Sean O'Sullivan | Nathan Adcock | Brian Duensing | | 82 | 139 | -57 |
| 2011-05-01 | @ KCA | 27 | L 3-10 | 9-18 | 5 | 18,108 | Carl Pavano | Luke Hochevar | Luke Hochevar | Carl Pavano | | 85 | 149 | -64 |
| 2011-05-03 | @ CHA | 28 | W 1-0 | 10-18 | 4 | 20,901 | Francisco Liriano | Edwin Jackson | Francisco Liriano | Edwin Jackson | | 86 | 149 | -63 |
| 2011-05-04 | @ CHA | 29 | W 3-2 | 11-18 | 4 | 18,028 | Nick Blackburn | John Danks | Nick Blackburn | John Danks | Matt Capps | 89 | 151 | -62 |
| 2011-05-06 | @ BOS | 30 | W 9-2 | 12-18 | 4 | 37,798 | Scott Baker | Tim Wakefield | Scott Baker | Tim Wakefield | | 98 | 153 | -55 |
| 2011-05-07 | @ BOS | 31 | L 0-4 | 12-19 | 4 | 37,234 | Brian Duensing | Clay Buchholz | Clay Buchholz | Brian Duensing | | 98 | 157 | -59 |
| 2011-05-08 | @ BOS | 32 | L 5-9 | 12-20 | 4 | 37,526 | Carl Pavano | Daisuke Matsuzaka | Daisuke Matsuzaka | Carl Pavano | | 103 | 166 | -63 |
| 2011-05-09 | @ BOS | 33 | L 1-2 | 12-21 | 5 | 37,276 | Nick Blackburn | Josh Beckett | Hideki Okajima | Jim Hoey | | 104 | 168 | -64 |
| 2011-05-10 | vs DET | 34 | L 2-10 | 12-22 | 5 | 38,949 | Francisco Liriano | Rick Porcello | Rick Porcello | Francisco Liriano | | 106 | 178 | -72 |
| 2011-05-11 | vs DET | 35 | L 7-9 | 12-23 | 5 | 38,938 | Scott Baker | Phil Coke | Joaquin Benoit | Matt Capps | Jose Valverde | 113 | 187 | -74 |
| 2011-05-13 | vs TOR | 36 | L 0-2 | 12-24 | 5 | 38,809 | Carl Pavano | Ricky Romero | Ricky Romero | Alex Burnett | Frank Francisco | 113 | 189 | -76 |
| 2011-05-14 | vs TOR | 37 | L 3-9 | 12-25 | 5 | 39,934 | Nick Blackburn | Jo-Jo Reyes | Jon Rauch | Glen Perkins | | 116 | 198 | -82 |
| 2011-05-15 | vs TOR | 38 | L 3-11 | 12-26 | 5 | 39,301 | Brian Duensing | Brandon Morrow | Brandon Morrow | Brian Duensing | | 119 | 209 | -90 |
| 2011-05-16 | @ SEA | 39 | L 2-5 | 12-27 | 5 | 14,859 | Scott Baker | Michael Pineda | Michael Pineda | Scott Baker | | 121 | 214 | -93 |
| 2011-05-17 | @ SEA | 40 | W 2-1 | 13-27 | 5 | 16,015 | Francisco Liriano | Felix Hernandez | Francisco Liriano | Felix Hernandez | Matt Capps | 123 | 215 | -92 |
| 2011-05-18 | @ OAK | 41 | W 4-3 | 14-27 | 5 | 15,355 | Carl Pavano | Brandon McCarthy | Joe Nathan | Brian Fuentes | Matt Capps | 127 | 218 | -91 |
| 2011-05-19 | @ OAK | 42 | W 11-1 | 15-27 | 5 | 22,320 | Nick Blackburn | Tyson Ross | Nick Blackburn | Tyson Ross | | 138 | 219 | -81 |
| 2011-05-20 | @ ARI | 43 | L 7-8 | 15-28 | 5 | 27,450 | Brian Duensing | Ian Kennedy | Ian Kennedy | Brian Duensing | Joe Paterson | 145 | 227 | -82 |
| 2011-05-21 | @ ARI | 44 | L 6-9 | 15-29 | 5 | 39,776 | Scott Baker | Micah Owings | Aaron Heilman | Matt Capps | J.J. Putz | 151 | 236 | -85 |
| 2011-05-22 | @ ARI | 45 | L 2-3 | 15-30 | 5 | 31,017 | Francisco Liriano | Daniel Hudson | Daniel Hudson | Alex Burnett | J.J. Putz | 153 | 239 | -86 |
| 2011-05-23 | vs SEA | 46 | L 7-8 | 15-31 | 5 | 37,498 | Carl Pavano | Jason Vargas | Jamey Wright | Anthony Swarzak | Brandon League | 160 | 247 | -87 |
| 2011-05-24 | vs SEA | 47 | W 4-2 | 16-31 | 5 | 37,691 | Nick Blackburn | Doug Fister | Nick Blackburn | Doug Fister | | 164 | 249 | -85 |
| 2011-05-25 | vs SEA | 48 | L 0-3 | 16-32 | 5 | 38,860 | Brian Duensing | Erik Bedard | Erik Bedard | Brian Duensing | Brandon League | 164 | 252 | -88 |
| 2011-05-27 | vs ANA | 49 | L 5-6 | 16-33 | 5 | 38,976 | Scott Baker | Tyler Chatwood | Scott Downs | Jim Hoey | Jordan Walden | 169 | 258 | -89 |
| 2011-05-28 | vs ANA | 50 | W 1-0 | 17-33 | 5 | 39,824 | Anthony Swarzak | Jered Weaver | Alex Burnett | Hisanori Takahashi | | 170 | 258 | -88 |
| 2011-05-29 | vs ANA | 51 | L 5-6 | 17-34 | 6 | 39,867 | Carl Pavano | Dan Haren | Dan Haren | Carl Pavano | Jordan Walden | 175 | 264 | -89 |
| 2011-05-30 | @ DET | 52 | L 5-6 | 17-35 | 5 | 30,198 | Nick Blackburn | Brad Penny | Al Alburquerque | Alex Burnett | Jose Valverde | 180 | 270 | -90 |
| 2011-05-31 | @ DET | 53 | L 7-8 | 17-36 | 5 | 22,649 | Brian Duensing | Max Scherzer | Al Alburquerque | Phil Dumatrait | Joaquin Benoit | 187 | 278 | -91 |
| 2011-06-01 | @ DET | 54 | L 2-4 | 17-37 | 5 | 24,363 | Scott Baker | Rick Porcello | Rick Porcello | Scott Baker | Jose Valverde | 189 | 282 | -93 |
| 2011-06-02 | @ KCA | 55 | W 8-2 | 18-37 | 5 | 14,584 | Anthony Swarzak | Sean O'Sullivan | Anthony Swarzak | Sean O'Sullivan | | 197 | 284 | -87 |
| 2011-06-03 | @ KCA | 56 | W 5-2 | 19-37 | 5 | 32,443 | Carl Pavano | Danny Duffy | Carl Pavano | Danny Duffy | | 202 | 286 | -84 |
| 2011-06-04 | @ KCA | 57 | W 7-2 | 20-37 | 5 | 27,861 | Nick Blackburn | Luke Hochevar | Nick Blackburn | Luke Hochevar | | 209 | 288 | -79 |
| 2011-06-05 | @ KCA | 58 | W 6-0 | 21-37 | 5 | 21,704 | Brian Duensing | Jeff Francis | Brian Duensing | Jeff Francis | | 215 | 288 | -73 |
| 2011-06-06 | @ CLE | 59 | W 6-4 | 22-37 | 5 | 15,278 | Scott Baker | Josh Tomlin | Scott Baker | Josh Tomlin | Matt Capps | 221 | 292 | -71 |
| 2011-06-07 | @ CLE | 60 | L 0-1 | 22-38 | 5 | 15,498 | Francisco Liriano | Carlos Carrasco | Carlos Carrasco | Francisco Liriano | Chris Perez | 221 | 293 | -72 |
| 2011-06-08 | @ CLE | 61 | W 3-2 | 23-38 | 5 | 15,849 | Carl Pavano | Justin Masterson | Matt Capps | Chris Perez | Phil Dumatrait | 224 | 295 | -71 |
| 2011-06-09 | vs TEX | 62 | W 5-4 | 24-38 | 5 | 38,761 | Nick Blackburn | Derek Holland | Jim Hoey | Mark Lowe | | 229 | 299 | -70 |
| 2011-06-10 | vs TEX | 63 | L 3-9 | 24-39 | 5 | 38,907 | Brian Duensing | C.J. Wilson | C.J. Wilson | Brian Duensing | | 232 | 308 | -76 |
| 2011-06-11 | vs TEX | 64 | W 8-1 | 25-39 | 5 | 40,420 | Scott Baker | Colby Lewis | Scott Baker | Colby Lewis | | 240 | 309 | -69 |
| 2011-06-12 | vs TEX | 65 | W 6-1 | 26-39 | 5 | 39,281 | Francisco Liriano | Matt Harrison | Francisco Liriano | Matt Harrison | | 246 | 310 | -64 |
| 2011-06-15 | vs CHA | 66 | W 4-1 | 27-39 | 5 | 37,437 | Carl Pavano | Gavin Floyd | Carl Pavano | Gavin Floyd | | 250 | 311 | -61 |
| 2011-06-16 | vs CHA | 67 | W 1-0 | 28-39 | 5 | 39,484 | Nick Blackburn | Mark Buehrle | Nick Blackburn | Mark Buehrle | Matt Capps | 251 | 311 | -60 |
| 2011-06-17 | vs SDN | 68 | W 6-5 | 29-39 | 5 | 39,205 | Brian Duensing | Clayton Richard | Brian Duensing | Clayton Richard | Matt Capps | 257 | 316 | -59 |
| 2011-06-18 | vs SDN | 69 | W 1-0 | 30-39 | 5 | 40,225 | Scott Baker | Tim Stauffer | Scott Baker | Tim Stauffer | Matt Capps | 258 | 316 | -58 |
| 2011-06-19 | vs SDN | 70 | W 5-4 | 31-39 | 4 | 40,655 | Francisco Liriano | Dustin Moseley | Alex Burnett | Chad Qualls | | 263 | 320 | -57 |
| 2011-06-21 | @ SFN | 71 | W 9-2 | 32-39 | 4 | 41,958 | Carl Pavano | Madison Bumgarner | Carl Pavano | Madison Bumgarner | | 272 | 322 | -50 |
| 2011-06-22 | @ SFN | 72 | L 1-5 | 32-40 | 4 | 41,886 | Nick Blackburn | Ryan Vogelsong | Ryan Vogelsong | Nick Blackburn | | 273 | 327 | -54 |
| 2011-06-23 | @ SFN | 73 | L 1-2 | 32-41 | 4 | 42,481 | Brian Duensing | Tim Lincecum | Tim Lincecum | Brian Duensing | Brian Wilson | 274 | 329 | -55 |
| 2011-06-24 | @ MIL | 74 | L 3-4 | 32-42 | 4 | 39,819 | Scott Baker | Randy Wolf | Randy Wolf | Scott Baker | John Axford | 277 | 333 | -56 |
| 2011-06-25 | @ MIL | 75 | L 1-11 | 32-43 | 4 | 43,980 | Francisco Liriano | Yovani Gallardo | Yovani Gallardo | Francisco Liriano | | 278 | 344 | -66 |
| 2011-06-26 | @ MIL | 76 | L 2-6 | 32-44 | 5 | 41,624 | Carl Pavano | Chris Narveson | Chris Narveson | Carl Pavano | | 280 | 350 | -70 |
| 2011-06-27 | vs LAN | 77 | L 0-15 | 32-45 | 5 | 39,487 | Nick Blackburn | Chad Billingsley | Chad Billingsley | Nick Blackburn | | 280 | 365 | -85 |
| 2011-06-28 | vs LAN | 78 | W 6-4 | 33-45 | 4 | 39,755 | Brian Duensing | Ted Lilly | Brian Duensing | Ted Lilly | Matt Capps | 286 | 369 | -83 |
| 2011-06-29 | vs LAN | 79 | W 1-0 | 34-45 | 4 | 39,655 | Scott Baker | Rubby de la Rosa | Scott Baker | Rubby de la Rosa | Matt Capps | 287 | 369 | -82 |
| 2011-07-01 | vs MIL | 80 | W 6-2 | 35-45 | 4 | 40,812 | Francisco Liriano | Yovani Gallardo | Francisco Liriano | Yovani Gallardo | | 293 | 371 | -78 |
| 2011-07-02 | vs MIL | 81 | L 7-8 | 35-46 | 4 | 41,378 | Carl Pavano | Chris Narveson | Takashi Saito | Matt Capps | John Axford | 300 | 379 | -79 |
| 2011-07-03 | vs MIL | 82 | W 9-7 | 36-46 | 4 | 41,195 | Nick Blackburn | Zack Greinke | Phil Dumatrait | Kameron Loe | Glen Perkins | 309 | 386 | -77 |
| 2011-07-04 | vs TBA | 83 | W 7-0 | 37-46 | 4 | 39,528 | Brian Duensing | David Price | Brian Duensing | David Price | | 316 | 386 | -70 |
| 2011-07-05 | vs TBA | 84 | W 3-2 | 38-46 | 4 | 38,613 | Scott Baker | James Shields | Scott Baker | James Shields | Glen Perkins | 319 | 388 | -69 |
| 2011-07-06 | vs TBA | 85 | L 5-12 | 38-47 | 4 | 39,841 | Francisco Liriano | Wade Davis | J.P. Howell | Alex Burnett | | 324 | 400 | -76 |
| 2011-07-07 | @ CHA | 86 | W 6-2 | 39-47 | 4 | 26,395 | Carl Pavano | Philip Humber | Carl Pavano | Philip Humber | | 330 | 402 | -72 |
| 2011-07-08 | @ CHA | 87 | W 8-5 | 40-47 | 4 | 27,737 | Nick Blackburn | Gavin Floyd | Nick Blackburn | Gavin Floyd | Matt Capps | 338 | 407 | -69 |
| 2011-07-09 | @ CHA | 88 | L 3-4 | 40-48 | 4 | 30,055 | Brian Duensing | Mark Buehrle | Jesse Crain | Jose Mijares | | 341 | 411 | -70 |
| 2011-07-10 | @ CHA | 89 | W 6-3 | 41-48 | 4 | 30,042 | Anthony Swarzak | Jake Peavy | Anthony Swarzak | Jake Peavy | Matt Capps | 347 | 414 | -67 |
| 2011-07-14 | vs KCA | 90 | W 8-4 | 42-48 | 4 | 39,584 | Francisco Liriano | Bruce Chen | Francisco Liriano | Bruce Chen | | 355 | 418 | -63 |
| 2011-07-15 | vs KCA | 91 | L 1-2 | 42-49 | 4 | 39,177 | Nick Blackburn | Luke Hochevar | Tim Collins | Matt Capps | Joakim Soria | 356 | 420 | -64 |
| 2011-07-16 | vs KCA | 92 | W 4-3 | 43-49 | 4 | 41,295 | Carl Pavano | Jeff Francis | Glen Perkins | Jeff Francis | Joe Nathan | 360 | 423 | -63 |
| 2011-07-17 | vs KCA | 93 | W 4-3 | 44-49 | 4 | 38,786 | Brian Duensing | Felipe Paulino | Brian Duensing | Felipe Paulino | Joe Nathan | 364 | 426 | -62 |
| 2011-07-18 | vs CLE | 94 | L 2-5 | 44-51 | 6 | 39,768 | Anthony Swarzak | David Huff | David Huff | Anthony Swarzak | Vinnie Pestano | 366 | 431 | -65 |
| 2011-07-18 | vs CLE | 95 | L 3-6 | 44-51 | 6 | 38,491 | Scott Diamond | Fausto Carmona | Fausto Carmona | Scott Diamond | | 369 | 437 | -68 |
| 2011-07-19 | vs CLE | 96 | W 2-1 | 45-51 | 4 | 38,473 | Francisco Liriano | Justin Masterson | Glen Perkins | Chris Perez | | 371 | 438 | -67 |
| 2011-07-20 | vs CLE | 97 | W 7-5 | 46-51 | 4 | 39,167 | Nick Blackburn | Josh Tomlin | Matt Capps | Tony Sipp | Joe Nathan | 378 | 443 | -65 |
| 2011-07-21 | vs DET | 98 | L 2-6 | 46-52 | 4 | 40,149 | Carl Pavano | Justin Verlander | Justin Verlander | Carl Pavano | | 380 | 449 | -69 |
| 2011-07-22 | vs DET | 99 | L 2-8 | 46-53 | 4 | 40,691 | Brian Duensing | Max Scherzer | Max Scherzer | Brian Duensing | | 382 | 457 | -75 |
| 2011-07-23 | vs DET | 100 | W 4-1 | 47-53 | 4 | 40,764 | Scott Baker | Brad Penny | Scott Baker | Brad Penny | Joe Nathan | 386 | 458 | -72 |
| 2011-07-24 | vs DET | 101 | L 2-5 | 47-54 | 4 | 40,789 | Francisco Liriano | Rick Porcello | Rick Porcello | Francisco Liriano | Jose Valverde | 388 | 463 | -75 |
| 2011-07-25 | @ TEX | 102 | L 6-20 | 47-55 | 4 | 35,573 | Nick Blackburn | Derek Holland | Derek Holland | Nick Blackburn | | 394 | 483 | -89 |
| 2011-07-26 | @ TEX | 103 | W 9-8 | 48-55 | 4 | 30,581 | Carl Pavano | C.J. Wilson | Glen Perkins | Neftali Feliz | Joe Nathan | 403 | 491 | -88 |
| 2011-07-27 | @ TEX | 104 | W 7-2 | 49-55 | 4 | 35,950 | Brian Duensing | Colby Lewis | Brian Duensing | Colby Lewis | | 410 | 493 | -83 |
| 2011-07-28 | @ TEX | 105 | L 1-4 | 49-56 | 4 | 30,406 | Scott Baker | Matt Harrison | Matt Harrison | Scott Baker | Neftali Feliz | 411 | 497 | -86 |
| 2011-07-29 | @ OAK | 106 | W 9-5 | 50-56 | 4 | 25,656 | Francisco Liriano | Gio Gonzalez | Francisco Liriano | Gio Gonzalez | | 420 | 502 | -82 |
| 2011-07-30 | @ OAK | 107 | L 3-8 | 50-57 | 4 | 19,605 | Nick Blackburn | Guillermo Moscoso | Guillermo Moscoso | Nick Blackburn | | 423 | 510 | -87 |
| 2011-07-31 | @ OAK | 108 | L 3-7 | 50-58 | 4 | 22,452 | Carl Pavano | Brandon McCarthy | Brandon McCarthy | Carl Pavano | | 426 | 517 | -91 |
| 2011-08-02 | @ ANA | 109 | L 1-5 | 50-59 | 4 | 37,565 | Brian Duensing | Ervin Santana | Ervin Santana | Brian Duensing | | 427 | 522 | -95 |
| 2011-08-03 | @ ANA | 110 | W 11-4 | 51-59 | 4 | 35,555 | Scott Baker | Joel Pineiro | Anthony Swarzak | Joel Pineiro | | 438 | 526 | -88 |
| 2011-08-04 | @ ANA | 111 | L 1-7 | 51-60 | 4 | 40,365 | Francisco Liriano | Dan Haren | Dan Haren | Francisco Liriano | | 439 | 533 | -94 |
| 2011-08-05 | vs CHA | 112 | L 3-5 | 51-61 | 4 | 41,364 | Nick Blackburn | Mark Buehrle | Mark Buehrle | Nick Blackburn | Chris Sale | 442 | 538 | -96 |
| 2011-08-06 | vs CHA | 113 | L 1-6 | 51-62 | 4 | 41,030 | Carl Pavano | Zach Stewart | Zach Stewart | Carl Pavano | | 443 | 544 | -101 |
| 2011-08-07 | vs CHA | 114 | L 0-7 | 51-63 | 4 | 39,353 | Brian Duensing | Jake Peavy | Jake Peavy | Brian Duensing | | 443 | 551 | -108 |
| 2011-08-08 | vs BOS | 115 | L 6-8 | 51-64 | 4 | 40,080 | Scott Baker | Tim Wakefield | Alfredo Aceves | Glen Perkins | Jonathan Papelbon | 449 | 559 | -110 |
| 2011-08-09 | vs BOS | 116 | L 3-4 | 51-65 | 4 | 39,974 | Francisco Liriano | Erik Bedard | Matt Albers | Matt Capps | Jonathan Papelbon | 452 | 563 | -111 |
| 2011-08-10 | vs BOS | 117 | W 5-2 | 52-65 | 4 | 40,491 | Nick Blackburn | Jon Lester | Glen Perkins | Jon Lester | Joe Nathan | 457 | 565 | -108 |
| 2011-08-12 | @ CLE | 118 | L 2-3 | 52-66 | 4 | 31,364 | Carl Pavano | Justin Masterson | Rafael Perez | Glen Perkins | Chris Perez | 459 | 568 | -109 |
| 2011-08-13 | @ CLE | 119 | L 1-3 | 52-67 | 4 | 30,619 | Brian Duensing | Josh Tomlin | Josh Tomlin | Brian Duensing | Chris Perez | 460 | 571 | -111 |
| 2011-08-15 | @ DET | 120 | W 9-6 | 53-67 | 4 | 36,211 | Francisco Liriano | Rick Porcello | Francisco Liriano | Rick Porcello | Joe Nathan | 469 | 577 | -108 |
| 2011-08-16 | @ DET | 121 | L 1-7 | 53-68 | 4 | 40,589 | Nick Blackburn | Justin Verlander | Justin Verlander | Nick Blackburn | | 470 | 584 | -114 |
| 2011-08-17 | @ DET | 122 | W 6-5 | 54-68 | 4 | 34,835 | Carl Pavano | Brad Penny | Matt Capps | Jose Valverde | Joe Nathan | 476 | 589 | -113 |
| 2011-08-18 | vs NYA | 123 | L 4-8 | 54-69 | 4 | 41,126 | Brian Duensing | CC Sabathia | CC Sabathia | Brian Duensing | | 480 | 597 | -117 |
| 2011-08-19 | vs NYA | 124 | L 1-8 | 54-70 | 4 | 41,328 | Kevin Slowey | Phil Hughes | Phil Hughes | Kevin Slowey | | 481 | 605 | -124 |
| 2011-08-20 | vs NYA | 125 | W 9-4 | 55-70 | 4 | 41,254 | Francisco Liriano | A.J. Burnett | Francisco Liriano | A.J. Burnett | | 490 | 609 | -119 |
| 2011-08-21 | vs NYA | 126 | L 0-3 | 55-71 | 4 | 41,242 | Nick Blackburn | Ivan Nova | Ivan Nova | Phil Dumatrait | Mariano Rivera | 490 | 612 | -122 |
| 2011-08-22 | vs BAL | 127 | L 1-4 | 55-72 | 4 | 38,986 | Carl Pavano | Zachary Britton | Zachary Britton | Carl Pavano | Kevin Gregg | 491 | 616 | -125 |
| 2011-08-23 | vs BAL | 128 | L 1-8 | 55-73 | 5 | 38,786 | Brian Duensing | Alfredo Simon | Alfredo Simon | Brian Duensing | | 492 | 624 | -132 |
| 2011-08-24 | vs BAL | 129 | L 1-6 | 55-74 | 4 | 37,778 | Kevin Slowey | Jeremy Guthrie | Jeremy Guthrie | Kevin Slowey | | 493 | 630 | -137 |
| 2011-08-25 | vs BAL | 130 | L 1-6 | 55-75 | 4 | 38,406 | Francisco Liriano | Jo-Jo Reyes | Jo-Jo Reyes | Anthony Swarzak | | 494 | 636 | -142 |
| 2011-08-26 | vs DET | 131 | L 1-8 | 55-76 | 4 | 38,918 | Scott Diamond | Rick Porcello | Rick Porcello | Scott Diamond | | 495 | 644 | -149 |
| 2011-08-27 | vs DET | 132 | L 4-6 | 55-77 | 4 | 40,179 | Carl Pavano | Justin Verlander | Justin Verlander | Carl Pavano | Jose Valverde | 499 | 650 | -151 |
| 2011-08-28 | vs DET | 133 | W 11-4 | 56-77 | 4 | 39,130 | Brian Duensing | Brad Penny | Brian Duensing | Brad Penny | | 510 | 654 | -144 |
| 2011-08-29 | @ CHA | 134 | L 0-3 | 56-78 | 4 | 24,120 | Kevin Slowey | Mark Buehrle | Mark Buehrle | Kevin Slowey | Sergio Santos | 510 | 657 | -147 |
| 2011-08-30 | @ CHA | 135 | L 6-8 | 56-79 | 4 | 21,632 | Anthony Swarzak | Zach Stewart | Will Ohman | Anthony Swarzak | Sergio Santos | 516 | 665 | -149 |
| 2011-08-31 | @ CHA | 136 | W 7-6 | 57-79 | 4 | 20,346 | Scott Diamond | Jake Peavy | Scott Diamond | Jake Peavy | Joe Nathan | 523 | 671 | -148 |
| 2011-09-02 | @ ANA | 137 | W 13-5 | 58-79 | 4 | 37,198 | Carl Pavano | Tyler Chatwood | Carl Pavano | Tyler Chatwood | | 536 | 676 | -140 |
| 2011-09-03 | @ ANA | 138 | L 6-10 | 58-80 | 4 | 39,102 | Brian Duensing | Jered Weaver | Jered Weaver | Phil Dumatrait | | 542 | 686 | -144 |
| 2011-09-04 | @ ANA | 139 | L 1-4 | 58-81 | 4 | 36,638 | Kevin Slowey | Joel Pineiro | Joel Pineiro | Kevin Slowey | Jordan Walden | 543 | 690 | -147 |
| 2011-09-05 | vs CHA | 140 | L 1-2 | 58-83 | 7 | 40,252 | Anthony Swarzak | Philip Humber | Philip Humber | Anthony Swarzak | Chris Sale | 544 | 692 | -148 |
| 2011-09-05 | vs CHA | 141 | L 0-4 | 58-83 | 7 | 39,849 | Scott Diamond | Zach Stewart | Zach Stewart | Scott Diamond | | 544 | 696 | -152 |
| 2011-09-06 | vs CHA | 142 | L 0-3 | 58-84 | 5 | 36,959 | Liam Hendriks | Jake Peavy | Jake Peavy | Liam Hendriks | Sergio Santos | 544 | 699 | -155 |
| 2011-09-07 | vs CHA | 143 | W 5-4 | 59-84 | 5 | 38,359 | Carl Pavano | John Danks | Carl Pavano | John Danks | Joe Nathan | 549 | 703 | -154 |
| 2011-09-09 | @ DET | 144 | L 4-8 | 59-85 | 5 | 35,996 | Kevin Slowey | Brad Penny | Brad Penny | Kevin Slowey | | 553 | 711 | -158 |
| 2011-09-10 | @ DET | 145 | L 2-3 | 59-86 | 5 | 38,567 | Anthony Swarzak | Max Scherzer | Al Alburquerque | Glen Perkins | | 555 | 714 | -159 |
| 2011-09-11 | @ DET | 146 | L 1-2 | 59-87 | 5 | 36,972 | Scott Diamond | Doug Fister | Doug Fister | Scott Diamond | Jose Valverde | 556 | 716 | -160 |
| 2011-09-13 | @ KCA | 147 | L 0-4 | 59-88 | 5 | 25,253 | Carl Pavano | Bruce Chen | Bruce Chen | Carl Pavano | | 556 | 720 | -164 |
| 2011-09-14 | @ KCA | 148 | L 3-7 | 59-89 | 5 | 19,076 | Liam Hendriks | Luke Hochevar | Luke Hochevar | Liam Hendriks | Greg Holland | 559 | 727 | -168 |
| 2011-09-16 | vs CLE | 149 | L 6-7 | 59-90 | 5 | 37,942 | Kevin Slowey | Ubaldo Jimenez | Ubaldo Jimenez | Kevin Slowey | Chris Perez | 565 | 734 | -169 |
| 2011-09-17 | vs CLE | 150 | L 4-10 | 59-91 | 5 | 38,805 | Anthony Swarzak | Jeanmar Gomez | Jeanmar Gomez | Anthony Swarzak | | 569 | 744 | -175 |
| 2011-09-18 | vs CLE | 151 | L 5-6 | 59-92 | 5 | 37,012 | Carl Pavano | Justin Masterson | Justin Masterson | Carl Pavano | Chris Perez | 574 | 750 | -176 |
| 2011-09-19 | @ NYA | 152 | L 4-6 | 59-93 | 5 | 40,045 | Scott Diamond | A.J. Burnett | Cory Wade | Scott Diamond | Mariano Rivera | 578 | 756 | -178 |
| 2011-09-20 | vs SEA | 153 | L 4-5 | 59-94 | 7 | 35,995 | Liam Hendriks | Jason Vargas | Jason Vargas | Brian Duensing | Brandon League | 582 | 761 | -179 |
| 2011-09-21 | vs SEA | 154 | L 4-5 | 59-95 | 5 | 36,263 | Kevin Slowey | Michael Pineda | Cesar Jimenez | Kevin Slowey | Brandon League | 586 | 766 | -180 |
| 2011-09-22 | vs SEA | 155 | W 3-2 | 60-95 | 5 | 37,466 | Anthony Swarzak | Blake Beavan | Joe Nathan | Steve Delabar | | 589 | 768 | -179 |
| 2011-09-23 | @ CLE | 156 | L 5-6 | 60-96 | 5 | 36,807 | Carl Pavano | Justin Masterson | Chris Perez | Matt Capps | | 594 | 774 | -180 |
| 2011-09-24 | @ CLE | 157 | L 2-8 | 60-98 | 7 | 26,197 | Brian Duensing | David Huff | Zach Putnam | Francisco Liriano | | 596 | 782 | -186 |
| 2011-09-24 | @ CLE | 158 | L 6-7 | 60-98 | 7 | 30,748 | Scott Diamond | Mitch Talbot | Nick Hagadone | Jose Mijares | Chris Perez | 602 | 789 | -187 |
| 2011-09-25 | @ CLE | 159 | W 6-4 | 61-98 | 5 | 22,539 | Liam Hendriks | Fausto Carmona | Kyle Waldrop | Tony Sipp | Joe Nathan | 608 | 793 | -185 |
| 2011-09-26 | vs KCA | 160 | L 3-7 | 61-99 | 5 | 34,847 | Kevin Slowey | Felipe Paulino | Felipe Paulino | Kevin Slowey | | 611 | 800 | -189 |
| 2011-09-27 | vs KCA | 161 | W 7-4 | 62-99 | 5 | 34,228 | Anthony Swarzak | Sean O'Sullivan | Anthony Swarzak | Sean O'Sullivan | | 618 | 804 | -186 |
| 2011-09-28 | vs KCA | 162 | W 1-0 | 63-99 | 5 | 36,488 | Carl Pavano | Bruce Chen | Carl Pavano | Blake Wood | | 619 | 804 | -185 |