| 2011-03-31 | vs ANA | 1 | L 2-4 | 0-1 | 2 | 40,055 | Luke Hochevar | Jered Weaver | Jered Weaver | Luke Hochevar | Fernando Rodney | 2 | 4 | -2 |
| 2011-04-01 | vs ANA | 2 | W 2-1 | 1-1 | 2 | 13,302 | Jeff Francis | Dan Haren | Joakim Soria | Michael Kohn | | 4 | 5 | -1 |
| 2011-04-02 | vs ANA | 3 | W 5-4 | 2-1 | 2 | 17,328 | Kyle Davies | Ervin Santana | Aaron Crow | Kevin Jepsen | Joakim Soria | 9 | 9 | 0 |
| 2011-04-03 | vs ANA | 4 | W 12-9 | 3-1 | 1 | 14,085 | Bruce Chen | Scott Kazmir | Tim Collins | Jason Bulger | | 21 | 18 | 3 |
| 2011-04-05 | vs CHA | 5 | W 7-6 | 4-1 | 1 | 12,641 | Luke Hochevar | Gavin Floyd | Jeremy Jeffress | Tony Pena | | 28 | 24 | 4 |
| 2011-04-06 | vs CHA | 6 | L 7-10 | 4-2 | 1 | 13,360 | Jeff Francis | Mark Buehrle | Chris Sale | Sean O'Sullivan | | 35 | 34 | 1 |
| 2011-04-08 | @ DET | 7 | L 2-5 | 4-3 | 3 | 44,799 | Kyle Davies | Max Scherzer | Max Scherzer | Kyle Davies | Jose Valverde | 37 | 39 | -2 |
| 2011-04-09 | @ DET | 8 | W 3-1 | 5-3 | 3 | 33,810 | Bruce Chen | Phil Coke | Bruce Chen | Phil Coke | Joakim Soria | 40 | 40 | 0 |
| 2011-04-10 | @ DET | 9 | W 9-5 | 6-3 | 3 | 28,984 | Luke Hochevar | Rick Porcello | Luke Hochevar | Rick Porcello | Joakim Soria | 49 | 45 | 4 |
| 2011-04-12 | @ MIN | 10 | L 3-4 | 6-4 | 3 | 38,154 | Jeff Francis | Brian Duensing | Dusty Hughes | Rob Tejeda | | 52 | 49 | 3 |
| 2011-04-13 | @ MIN | 11 | W 10-5 | 7-4 | 2 | 36,286 | Kyle Davies | Francisco Liriano | Kyle Davies | Francisco Liriano | Jeremy Jeffress | 62 | 54 | 8 |
| 2011-04-14 | vs SEA | 12 | W 5-1 | 8-4 | 1 | 8,811 | Bruce Chen | Doug Fister | Bruce Chen | Doug Fister | | 67 | 55 | 12 |
| 2011-04-15 | vs SEA | 13 | W 6-5 | 9-4 | 2 | 13,686 | Luke Hochevar | Erik Bedard | Luke Hochevar | Erik Bedard | Joakim Soria | 73 | 60 | 13 |
| 2011-04-16 | vs SEA | 14 | W 7-0 | 10-4 | 2 | 22,364 | Sean O'Sullivan | Felix Hernandez | Sean O'Sullivan | Felix Hernandez | | 80 | 60 | 20 |
| 2011-04-17 | vs SEA | 15 | L 2-3 | 10-5 | 2 | 19,424 | Jeff Francis | Michael Pineda | Michael Pineda | Jeff Francis | Brandon League | 82 | 63 | 19 |
| 2011-04-18 | vs CLE | 16 | L 3-7 | 10-6 | 2 | 12,214 | Kyle Davies | Carlos Carrasco | Joe Smith | Tim Collins | | 85 | 70 | 15 |
| 2011-04-19 | vs CLE | 17 | W 5-4 | 11-6 | 2 | 10,506 | Bruce Chen | Jeanmar Gomez | Bruce Chen | Jeanmar Gomez | Joakim Soria | 90 | 74 | 16 |
| 2011-04-20 | vs CLE | 18 | L 5-7 | 11-7 | 2 | 10,080 | Luke Hochevar | Justin Masterson | Justin Masterson | Luke Hochevar | Chris Perez | 95 | 81 | 14 |
| 2011-04-21 | vs CLE | 19 | W 3-2 | 12-7 | 2 | 9,279 | Sean O'Sullivan | Josh Tomlin | Aaron Crow | Chris Perez | | 98 | 83 | 15 |
| 2011-04-22 | @ TEX | 20 | L 6-11 | 12-8 | 2 | 45,769 | Jeff Francis | Derek Holland | Derek Holland | Jeff Francis | | 104 | 94 | 10 |
| 2011-04-23 | @ TEX | 21 | L 1-3 | 12-9 | 2 | 45,506 | Kyle Davies | Alexi Ogando | Alexi Ogando | Kyle Davies | Darren Oliver | 105 | 97 | 8 |
| 2011-04-24 | @ TEX | 22 | L 7-8 | 12-10 | 3 | 28,284 | Bruce Chen | C.J. Wilson | C.J. Wilson | Bruce Chen | Arthur Rhodes | 112 | 105 | 7 |
| 2011-04-26 | @ CLE | 23 | L 4-9 | 12-11 | 3 | 9,650 | Luke Hochevar | Justin Masterson | Justin Masterson | Luke Hochevar | | 116 | 114 | 2 |
| 2011-04-27 | @ CLE | 24 | L 2-7 | 12-12 | 3 | 9,722 | Jeff Francis | Josh Tomlin | Josh Tomlin | Jeff Francis | | 118 | 121 | -3 |
| 2011-04-28 | @ CLE | 25 | L 2-8 | 12-13 | 3 | 9,076 | Kyle Davies | Fausto Carmona | Fausto Carmona | Kyle Davies | | 120 | 129 | -9 |
| 2011-04-29 | vs MIN | 26 | W 4-3 | 13-13 | 2 | 31,407 | Bruce Chen | Scott Baker | Blake Wood | Alex Burnett | Joakim Soria | 124 | 132 | -8 |
| 2011-04-30 | vs MIN | 27 | W 11-2 | 14-13 | 2 | 22,099 | Sean O'Sullivan | Brian Duensing | Nathan Adcock | Brian Duensing | | 135 | 134 | 1 |
| 2011-05-01 | vs MIN | 28 | W 10-3 | 15-13 | 2 | 18,108 | Luke Hochevar | Carl Pavano | Luke Hochevar | Carl Pavano | | 145 | 137 | 8 |
| 2011-05-03 | vs BAL | 29 | W 6-5 | 16-13 | 2 | 11,986 | Jeff Francis | Brad Bergesen | Tim Collins | Jason Berken | | 151 | 142 | 9 |
| 2011-05-04 | vs BAL | 30 | L 2-3 | 16-14 | 2 | 11,130 | Kyle Davies | Jake Arrieta | Jake Arrieta | Kyle Davies | Kevin Gregg | 153 | 145 | 8 |
| 2011-05-05 | vs BAL | 31 | W 9-1 | 17-14 | 2 | 29,927 | Bruce Chen | Chris Tillman | Bruce Chen | Chris Tillman | | 162 | 146 | 16 |
| 2011-05-06 | vs OAK | 32 | L 2-3 | 17-15 | 2 | 30,690 | Sean O'Sullivan | Gio Gonzalez | Gio Gonzalez | Sean O'Sullivan | Brian Fuentes | 164 | 149 | 15 |
| 2011-05-07 | vs OAK | 33 | W 4-3 | 18-15 | 2 | 25,828 | Luke Hochevar | Brandon McCarthy | Joakim Soria | Brandon McCarthy | | 168 | 152 | 16 |
| 2011-05-08 | vs OAK | 34 | L 2-5 | 18-16 | 2 | 22,435 | Jeff Francis | Tyson Ross | Tyson Ross | Jeff Francis | Brian Fuentes | 170 | 157 | 13 |
| 2011-05-10 | @ NYA | 35 | L 1-3 | 18-17 | 2 | 41,275 | Kyle Davies | Freddy Garcia | Freddy Garcia | Kyle Davies | Mariano Rivera | 171 | 160 | 11 |
| 2011-05-11 | @ NYA | 36 | W 4-3 | 19-17 | 2 | 40,164 | Vin Mazzaro | A.J. Burnett | Joakim Soria | Buddy Carlyle | Louis Coleman | 175 | 163 | 12 |
| 2011-05-12 | @ NYA | 37 | W 11-5 | 20-17 | 2 | 41,790 | Sean O'Sullivan | Ivan Nova | Sean O'Sullivan | Ivan Nova | | 186 | 168 | 18 |
| 2011-05-13 | @ DET | 38 | L 1-3 | 20-18 | 3 | 33,641 | Luke Hochevar | Justin Verlander | Justin Verlander | Luke Hochevar | Jose Valverde | 187 | 171 | 16 |
| 2011-05-14 | @ DET | 39 | L 0-3 | 20-19 | 3 | 37,647 | Jeff Francis | Brad Penny | Brad Penny | Jeff Francis | Jose Valverde | 187 | 174 | 13 |
| 2011-05-16 | vs CLE | 40 | L 1-19 | 20-20 | 3 | 12,242 | Kyle Davies | Josh Tomlin | Josh Tomlin | Kyle Davies | | 188 | 193 | -5 |
| 2011-05-17 | vs CLE | 41 | L 3-7 | 20-21 | 3 | 17,712 | Sean O'Sullivan | Carlos Carrasco | Carlos Carrasco | Sean O'Sullivan | | 191 | 200 | -9 |
| 2011-05-18 | vs TEX | 42 | L 4-5 | 20-22 | 3 | 13,789 | Danny Duffy | Alexi Ogando | Arthur Rhodes | Jeremy Jeffress | Mark Lowe | 195 | 205 | -10 |
| 2011-05-19 | vs TEX | 43 | W 2-1 | 21-22 | 3 | 12,355 | Luke Hochevar | Derek Holland | Greg Holland | Darren Oliver | | 197 | 206 | -9 |
| 2011-05-20 | vs SLN | 44 | W 3-0 | 22-22 | 3 | 26,816 | Jeff Francis | Chris Carpenter | Jeff Francis | Chris Carpenter | Joakim Soria | 200 | 206 | -6 |
| 2011-05-21 | vs SLN | 45 | L 0-3 | 22-23 | 3 | 32,229 | Nathan Adcock | Jake Westbrook | Jake Westbrook | Tim Collins | Fernando Salas | 200 | 209 | -9 |
| 2011-05-22 | vs SLN | 46 | L 8-9 | 22-24 | 3 | 28,195 | Sean O'Sullivan | Jaime Garcia | Jason Motte | Louis Coleman | Fernando Salas | 208 | 218 | -10 |
| 2011-05-24 | @ BAL | 47 | L 3-5 | 22-25 | 3 | 14,077 | Danny Duffy | Zachary Britton | Alfredo Simon | Joakim Soria | | 211 | 223 | -12 |
| 2011-05-25 | @ BAL | 48 | L 2-9 | 22-26 | 3 | 15,740 | Luke Hochevar | Jake Arrieta | Jake Arrieta | Luke Hochevar | | 213 | 232 | -19 |
| 2011-05-26 | @ BAL | 49 | L 5-6 | 22-27 | 4 | 22,720 | Jeff Francis | Jeremy Guthrie | Jeremy Accardo | Louis Coleman | | 218 | 238 | -20 |
| 2011-05-27 | @ TEX | 50 | W 12-7 | 23-27 | 3 | 39,390 | Nathan Adcock | Colby Lewis | Blake Wood | David Bush | | 230 | 245 | -15 |
| 2011-05-28 | @ TEX | 51 | L 1-10 | 23-28 | 3 | 40,240 | Sean O'Sullivan | Matt Harrison | Matt Harrison | Sean O'Sullivan | Yoshinori Tateyama | 231 | 255 | -24 |
| 2011-05-29 | @ TEX | 52 | L 6-7 | 23-29 | 4 | 45,011 | Danny Duffy | Alexi Ogando | Arthur Rhodes | Joakim Soria | | 237 | 262 | -25 |
| 2011-05-30 | vs ANA | 53 | L 8-10 | 23-30 | 4 | 24,406 | Luke Hochevar | Ervin Santana | Kevin Jepsen | Joakim Soria | Fernando Rodney | 245 | 272 | -27 |
| 2011-05-31 | vs ANA | 54 | W 7-3 | 24-30 | 4 | 14,174 | Jeff Francis | Joel Pineiro | Jeff Francis | Joel Pineiro | | 252 | 275 | -23 |
| 2011-06-01 | vs ANA | 55 | W 2-0 | 25-30 | 4 | 12,022 | Felipe Paulino | Tyler Chatwood | Tim Collins | Scott Downs | | 254 | 275 | -21 |
| 2011-06-02 | vs MIN | 56 | L 2-8 | 25-31 | 4 | 14,584 | Sean O'Sullivan | Anthony Swarzak | Anthony Swarzak | Sean O'Sullivan | | 256 | 283 | -27 |
| 2011-06-03 | vs MIN | 57 | L 2-5 | 25-32 | 4 | 32,443 | Danny Duffy | Carl Pavano | Carl Pavano | Danny Duffy | | 258 | 288 | -30 |
| 2011-06-04 | vs MIN | 58 | L 2-7 | 25-33 | 4 | 27,861 | Luke Hochevar | Nick Blackburn | Nick Blackburn | Luke Hochevar | | 260 | 295 | -35 |
| 2011-06-05 | vs MIN | 59 | L 0-6 | 25-34 | 4 | 21,704 | Jeff Francis | Brian Duensing | Brian Duensing | Jeff Francis | | 260 | 301 | -41 |
| 2011-06-06 | vs TOR | 60 | W 3-2 | 26-34 | 4 | 12,194 | Felipe Paulino | Brandon Morrow | Joakim Soria | Frank Francisco | | 263 | 303 | -40 |
| 2011-06-07 | vs TOR | 61 | L 5-8 | 26-35 | 4 | 16,539 | Vin Mazzaro | Kyle Drabek | Kyle Drabek | Vin Mazzaro | Jon Rauch | 268 | 311 | -43 |
| 2011-06-08 | vs TOR | 62 | L 8-9 | 26-36 | 4 | 12,152 | Danny Duffy | Carlos Villanueva | Carlos Villanueva | Danny Duffy | Casey Janssen | 276 | 320 | -44 |
| 2011-06-09 | vs TOR | 63 | W 3-2 | 27-36 | 4 | 13,941 | Luke Hochevar | Ricky Romero | Luke Hochevar | Ricky Romero | Joakim Soria | 279 | 322 | -43 |
| 2011-06-10 | @ ANA | 64 | W 4-2 | 28-36 | 4 | 38,254 | Jeff Francis | Ervin Santana | Jeff Francis | Ervin Santana | Joakim Soria | 283 | 324 | -41 |
| 2011-06-11 | @ ANA | 65 | L 5-7 | 28-37 | 4 | 38,911 | Felipe Paulino | Joel Pineiro | Scott Downs | Tim Collins | Jordan Walden | 288 | 331 | -43 |
| 2011-06-12 | @ ANA | 66 | W 9-0 | 29-37 | 4 | 39,114 | Vin Mazzaro | Tyler Chatwood | Vin Mazzaro | Tyler Chatwood | | 297 | 331 | -34 |
| 2011-06-14 | @ OAK | 67 | W 7-4 | 30-37 | 4 | 11,439 | Danny Duffy | Trevor Cahill | Danny Duffy | Trevor Cahill | Joakim Soria | 304 | 335 | -31 |
| 2011-06-15 | @ OAK | 68 | L 1-2 | 30-38 | 4 | 16,392 | Luke Hochevar | Josh Outman | Josh Outman | Luke Hochevar | Andrew Bailey | 305 | 337 | -32 |
| 2011-06-16 | @ OAK | 69 | L 4-8 | 30-39 | 4 | 11,775 | Jeff Francis | Gio Gonzalez | Gio Gonzalez | Jeff Francis | | 309 | 345 | -36 |
| 2011-06-17 | @ SLN | 70 | W 5-4 | 31-39 | 4 | 40,674 | Felipe Paulino | Chris Carpenter | Blake Wood | Chris Carpenter | Joakim Soria | 314 | 349 | -35 |
| 2011-06-18 | @ SLN | 71 | L 4-5 | 31-40 | 4 | 43,102 | Vin Mazzaro | Jake Westbrook | Jason Motte | Greg Holland | Fernando Salas | 318 | 354 | -36 |
| 2011-06-19 | @ SLN | 72 | L 4-5 | 31-41 | 5 | 41,660 | Danny Duffy | Jaime Garcia | Fernando Salas | Tim Collins | | 322 | 359 | -37 |
| 2011-06-21 | vs ARI | 73 | L 2-7 | 31-42 | 5 | 19,305 | Luke Hochevar | Joe Saunders | Joe Saunders | Luke Hochevar | | 324 | 366 | -42 |
| 2011-06-22 | vs ARI | 74 | L 2-3 | 31-43 | 5 | 14,265 | Jeff Francis | Ian Kennedy | Ian Kennedy | Jeff Francis | J.J. Putz | 326 | 369 | -43 |
| 2011-06-23 | vs ARI | 75 | L 3-5 | 31-44 | 5 | 23,610 | Felipe Paulino | Daniel Hudson | Daniel Hudson | Felipe Paulino | J.J. Putz | 329 | 374 | -45 |
| 2011-06-24 | vs CHN | 76 | L 4-6 | 31-45 | 5 | 32,921 | Bruce Chen | Ryan Dempster | Sean Marshall | Aaron Crow | Carlos Marmol | 333 | 380 | -47 |
| 2011-06-25 | vs CHN | 77 | W 3-2 | 32-45 | 5 | 38,744 | Danny Duffy | Carlos Zambrano | Greg Holland | Jeff Samardzija | Joakim Soria | 336 | 382 | -46 |
| 2011-06-26 | vs CHN | 78 | W 6-3 | 33-45 | 4 | 28,401 | Luke Hochevar | Randy Wells | Luke Hochevar | Randy Wells | Joakim Soria | 342 | 385 | -43 |
| 2011-06-27 | @ SDN | 79 | L 3-4 | 33-46 | 4 | 23,635 | Jeff Francis | Mat Latos | Mat Latos | Jeff Francis | Heath Bell | 345 | 389 | -44 |
| 2011-06-28 | @ SDN | 80 | L 2-4 | 33-47 | 5 | 20,250 | Felipe Paulino | Clayton Richard | Clayton Richard | Felipe Paulino | Heath Bell | 347 | 393 | -46 |
| 2011-06-29 | @ SDN | 81 | L 1-4 | 33-48 | 5 | 24,461 | Bruce Chen | Tim Stauffer | Tim Stauffer | Bruce Chen | Heath Bell | 348 | 397 | -49 |
| 2011-07-01 | @ COL | 82 | L 0-9 | 33-49 | 5 | 48,282 | Danny Duffy | Juan Nicasio | Juan Nicasio | Danny Duffy | | 348 | 406 | -58 |
| 2011-07-02 | @ COL | 83 | L 6-9 | 33-50 | 5 | 49,227 | Kyle Davies | Greg Reynolds | Greg Reynolds | Kyle Davies | Huston Street | 354 | 415 | -61 |
| 2011-07-03 | @ COL | 84 | W 16-8 | 34-50 | 5 | 40,269 | Luke Hochevar | Jason Hammel | Blake Wood | Jason Hammel | | 370 | 423 | -53 |
| 2011-07-04 | @ CHA | 85 | L 4-5 | 34-51 | 5 | 31,077 | Jeff Francis | Mark Buehrle | Sergio Santos | Aaron Crow | | 374 | 428 | -54 |
| 2011-07-05 | @ CHA | 86 | W 5-3 | 35-51 | 5 | 20,695 | Felipe Paulino | Jake Peavy | Felipe Paulino | Jake Peavy | Joakim Soria | 379 | 431 | -52 |
| 2011-07-06 | @ CHA | 87 | W 4-1 | 36-51 | 5 | 27,233 | Bruce Chen | Edwin Jackson | Bruce Chen | Edwin Jackson | Joakim Soria | 383 | 432 | -49 |
| 2011-07-07 | vs DET | 88 | L 1-3 | 36-52 | 5 | 16,355 | Danny Duffy | Max Scherzer | Max Scherzer | Danny Duffy | Jose Valverde | 384 | 435 | -51 |
| 2011-07-08 | vs DET | 89 | L 4-6 | 36-53 | 5 | 34,563 | Kyle Davies | Rick Porcello | Rick Porcello | Kyle Davies | Jose Valverde | 388 | 441 | -53 |
| 2011-07-09 | vs DET | 90 | W 13-6 | 37-53 | 5 | 25,941 | Luke Hochevar | Charlie Furbush | Greg Holland | Charlie Furbush | Everett Teaford | 401 | 447 | -46 |
| 2011-07-10 | vs DET | 91 | L 1-2 | 37-54 | 5 | 18,373 | Jeff Francis | Justin Verlander | Justin Verlander | Jeff Francis | Jose Valverde | 402 | 449 | -47 |
| 2011-07-14 | @ MIN | 92 | L 4-8 | 37-55 | 5 | 39,584 | Bruce Chen | Francisco Liriano | Francisco Liriano | Bruce Chen | | 406 | 457 | -51 |
| 2011-07-15 | @ MIN | 93 | W 2-1 | 38-55 | 5 | 39,177 | Luke Hochevar | Nick Blackburn | Tim Collins | Matt Capps | Joakim Soria | 408 | 458 | -50 |
| 2011-07-16 | @ MIN | 94 | L 3-4 | 38-56 | 5 | 41,295 | Jeff Francis | Carl Pavano | Glen Perkins | Jeff Francis | Joe Nathan | 411 | 462 | -51 |
| 2011-07-17 | @ MIN | 95 | L 3-4 | 38-57 | 5 | 38,786 | Felipe Paulino | Brian Duensing | Brian Duensing | Felipe Paulino | Joe Nathan | 414 | 466 | -52 |
| 2011-07-18 | vs CHA | 96 | L 2-5 | 38-58 | 7 | 17,190 | Kyle Davies | Mark Buehrle | Mark Buehrle | Kyle Davies | | 416 | 471 | -55 |
| 2011-07-19 | vs CHA | 97 | W 4-2 | 39-58 | 5 | 20,126 | Danny Duffy | Jake Peavy | Danny Duffy | Jake Peavy | Joakim Soria | 420 | 473 | -53 |
| 2011-07-20 | vs CHA | 98 | W 2-1 | 40-58 | 5 | 13,831 | Bruce Chen | John Danks | Aaron Crow | Chris Sale | | 422 | 474 | -52 |
| 2011-07-22 | vs TBA | 99 | W 10-4 | 41-58 | 5 | 27,824 | Luke Hochevar | Wade Davis | Luke Hochevar | Wade Davis | | 432 | 478 | -46 |
| 2011-07-23 | vs TBA | 100 | W 5-4 | 42-58 | 5 | 27,643 | Jeff Francis | Jeff Niemann | Joakim Soria | Brandon Gomes | | 437 | 482 | -45 |
| 2011-07-24 | vs TBA | 101 | L 0-5 | 42-59 | 5 | 23,735 | Felipe Paulino | Alex Cobb | Alex Cobb | Felipe Paulino | | 437 | 487 | -50 |
| 2011-07-25 | @ BOS | 102 | W 3-1 | 43-59 | 5 | 37,727 | Kyle Davies | Jon Lester | Louis Coleman | Randy Williams | Joakim Soria | 440 | 488 | -48 |
| 2011-07-26 | @ BOS | 103 | L 9-13 | 43-60 | 5 | 37,460 | Danny Duffy | Andrew Miller | Alfredo Aceves | Nathan Adcock | | 449 | 501 | -52 |
| 2011-07-27 | @ BOS | 104 | L 5-12 | 43-61 | 5 | 38,329 | Bruce Chen | John Lackey | John Lackey | Bruce Chen | | 454 | 513 | -59 |
| 2011-07-28 | @ BOS | 105 | W 4-3 | 44-61 | 5 | 37,822 | Luke Hochevar | Josh Beckett | Luke Hochevar | Josh Beckett | Joakim Soria | 458 | 516 | -58 |
| 2011-07-29 | @ CLE | 106 | W 12-0 | 45-61 | 5 | 35,390 | Jeff Francis | Carlos Carrasco | Jeff Francis | Carlos Carrasco | | 470 | 516 | -46 |
| 2011-07-30 | @ CLE | 107 | L 2-5 | 45-62 | 5 | 31,436 | Felipe Paulino | Justin Masterson | Tony Sipp | Joakim Soria | | 472 | 521 | -49 |
| 2011-07-31 | @ CLE | 108 | W 5-3 | 46-62 | 5 | 21,101 | Danny Duffy | Fausto Carmona | Danny Duffy | Fausto Carmona | Joakim Soria | 477 | 524 | -47 |
| 2011-08-02 | vs BAL | 109 | L 2-8 | 46-63 | 5 | 17,116 | Bruce Chen | Alfredo Simon | Alfredo Simon | Bruce Chen | | 479 | 532 | -53 |
| 2011-08-03 | vs BAL | 110 | W 6-2 | 47-63 | 5 | 14,187 | Luke Hochevar | Jeremy Guthrie | Luke Hochevar | Jeremy Guthrie | Greg Holland | 485 | 534 | -49 |
| 2011-08-04 | vs BAL | 111 | W 9-4 | 48-63 | 5 | 12,161 | Jeff Francis | Zachary Britton | Blake Wood | Zachary Britton | | 494 | 538 | -44 |
| 2011-08-05 | vs DET | 112 | L 3-4 | 48-64 | 5 | 28,565 | Felipe Paulino | Rick Porcello | Daniel Schlereth | Aaron Crow | Jose Valverde | 497 | 542 | -45 |
| 2011-08-06 | vs DET | 113 | L 3-4 | 48-65 | 5 | 25,818 | Danny Duffy | Justin Verlander | Justin Verlander | Danny Duffy | Jose Valverde | 500 | 546 | -46 |
| 2011-08-07 | vs DET | 114 | W 4-3 | 49-65 | 5 | 20,132 | Bruce Chen | Max Scherzer | Bruce Chen | Max Scherzer | Joakim Soria | 504 | 549 | -45 |
| 2011-08-08 | @ TBA | 115 | L 1-2 | 49-66 | 5 | 10,742 | Luke Hochevar | Jeremy Hellickson | Kyle Farnsworth | Blake Wood | | 505 | 551 | -46 |
| 2011-08-09 | @ TBA | 116 | L 0-4 | 49-67 | 5 | 10,124 | Jeff Francis | James Shields | James Shields | Jeff Francis | | 505 | 555 | -50 |
| 2011-08-10 | @ TBA | 117 | L 7-8 | 49-68 | 5 | 11,706 | Felipe Paulino | Wade Davis | Jake McGee | Joakim Soria | | 512 | 563 | -51 |
| 2011-08-11 | @ TBA | 118 | L 1-4 | 49-69 | 5 | 13,942 | Danny Duffy | Jeff Niemann | Jeff Niemann | Danny Duffy | Kyle Farnsworth | 513 | 567 | -54 |
| 2011-08-12 | @ CHA | 119 | W 5-1 | 50-69 | 5 | 23,130 | Bruce Chen | Zach Stewart | Bruce Chen | Zach Stewart | Greg Holland | 518 | 568 | -50 |
| 2011-08-13 | @ CHA | 120 | L 4-5 | 50-70 | 5 | 24,854 | Luke Hochevar | Jake Peavy | Jesse Crain | Luke Hochevar | Chris Sale | 522 | 573 | -51 |
| 2011-08-14 | @ CHA | 121 | L 2-6 | 50-71 | 5 | 25,517 | Jeff Francis | John Danks | John Danks | Jeff Francis | | 524 | 579 | -55 |
| 2011-08-15 | vs NYA | 122 | L 4-7 | 50-72 | 5 | 24,879 | Felipe Paulino | A.J. Burnett | A.J. Burnett | Felipe Paulino | Mariano Rivera | 528 | 586 | -58 |
| 2011-08-16 | vs NYA | 123 | L 7-9 | 50-73 | 5 | 22,258 | Danny Duffy | Ivan Nova | Ivan Nova | Danny Duffy | Mariano Rivera | 535 | 595 | -60 |
| 2011-08-17 | vs NYA | 124 | W 5-4 | 51-73 | 5 | 22,435 | Bruce Chen | Bartolo Colon | Bruce Chen | Bartolo Colon | Joakim Soria | 540 | 599 | -59 |
| 2011-08-18 | vs BOS | 125 | L 3-4 | 51-74 | 5 | 20,547 | Luke Hochevar | Josh Beckett | Josh Beckett | Luke Hochevar | Jonathan Papelbon | 543 | 603 | -60 |
| 2011-08-19 | vs BOS | 126 | L 1-7 | 51-75 | 5 | 21,262 | Jeff Francis | Andrew Miller | Andrew Miller | Jeff Francis | Alfredo Aceves | 544 | 610 | -66 |
| 2011-08-20 | vs BOS | 127 | W 9-4 | 52-75 | 5 | 28,588 | Felipe Paulino | Tim Wakefield | Felipe Paulino | Matt Albers | | 553 | 614 | -61 |
| 2011-08-21 | vs BOS | 128 | L 1-6 | 52-76 | 5 | 25,723 | Danny Duffy | Jon Lester | Jon Lester | Danny Duffy | | 554 | 620 | -66 |
| 2011-08-23 | @ TOR | 129 | W 6-4 | 53-76 | 6 | 20,009 | Bruce Chen | Brandon Morrow | Bruce Chen | Brandon Morrow | Joakim Soria | 560 | 624 | -64 |
| 2011-08-24 | @ TOR | 130 | L 3-4 | 53-77 | 5 | 18,292 | Luke Hochevar | Ricky Romero | Jesse Litsch | Louis Coleman | Frank Francisco | 563 | 628 | -65 |
| 2011-08-25 | @ TOR | 131 | W 9-6 | 54-77 | 5 | 17,355 | Jeff Francis | Brett Cecil | Jeff Francis | Brett Cecil | | 572 | 634 | -62 |
| 2011-08-26 | @ CLE | 132 | L 1-2 | 54-78 | 5 | 41,337 | Felipe Paulino | Ubaldo Jimenez | Ubaldo Jimenez | Felipe Paulino | Chris Perez | 573 | 636 | -63 |
| 2011-08-27 | @ CLE | 133 | L 7-8 | 54-79 | 5 | 35,370 | Danny Duffy | Fausto Carmona | Joe Smith | Louis Coleman | Chris Perez | 580 | 644 | -64 |
| 2011-08-28 | @ CLE | 134 | W 2-1 | 55-79 | 5 | 27,908 | Bruce Chen | Justin Masterson | Bruce Chen | Justin Masterson | Joakim Soria | 582 | 645 | -63 |
| 2011-08-29 | @ DET | 135 | W 9-5 | 56-79 | 5 | 32,423 | Luke Hochevar | Max Scherzer | Luke Hochevar | Max Scherzer | Blake Wood | 591 | 650 | -59 |
| 2011-08-30 | @ DET | 136 | L 1-2 | 56-80 | 5 | 34,866 | Jeff Francis | Doug Fister | Joaquin Benoit | Aaron Crow | | 592 | 652 | -60 |
| 2011-08-31 | @ DET | 137 | L 4-5 | 56-81 | 5 | 33,572 | Nathan Adcock | Rick Porcello | Daniel Schlereth | Blake Wood | Jose Valverde | 596 | 657 | -61 |
| 2011-09-01 | @ DET | 138 | W 11-8 | 57-81 | 5 | 39,084 | Danny Duffy | Jacob Turner | Aaron Crow | Phil Coke | Joakim Soria | 607 | 665 | -58 |
| 2011-09-02 | vs CLE | 139 | L 4-5 | 57-82 | 5 | 27,251 | Bruce Chen | Justin Masterson | Justin Masterson | Bruce Chen | Chris Perez | 611 | 670 | -59 |
| 2011-09-03 | vs CLE | 140 | W 5-1 | 58-82 | 5 | 27,126 | Luke Hochevar | David Huff | Luke Hochevar | David Huff | | 616 | 671 | -55 |
| 2011-09-04 | vs CLE | 141 | L 6-9 | 58-83 | 5 | 34,015 | Jeff Francis | Jeanmar Gomez | Jeanmar Gomez | Jeff Francis | Chris Perez | 622 | 680 | -58 |
| 2011-09-05 | @ OAK | 142 | W 11-6 | 59-83 | 5 | 14,577 | Felipe Paulino | Rich Harden | Greg Holland | Andrew Bailey | | 633 | 686 | -53 |
| 2011-09-06 | @ OAK | 143 | W 7-4 | 60-83 | 4 | 12,064 | Danny Duffy | Gio Gonzalez | Danny Duffy | Gio Gonzalez | Joakim Soria | 640 | 690 | -50 |
| 2011-09-07 | @ OAK | 144 | L 0-7 | 60-84 | 4 | 13,132 | Bruce Chen | Guillermo Moscoso | Guillermo Moscoso | Bruce Chen | | 640 | 697 | -57 |
| 2011-09-08 | @ SEA | 145 | L 1-4 | 60-85 | 4 | 14,377 | Luke Hochevar | Jason Vargas | Jason Vargas | Luke Hochevar | Brandon League | 641 | 701 | -60 |
| 2011-09-09 | @ SEA | 146 | L 3-7 | 60-86 | 4 | 14,805 | Jeff Francis | Blake Beavan | Blake Beavan | Jeff Francis | | 644 | 708 | -64 |
| 2011-09-10 | @ SEA | 147 | W 4-2 | 61-86 | 4 | 17,884 | Felipe Paulino | Michael Pineda | Felipe Paulino | Michael Pineda | Joakim Soria | 648 | 710 | -62 |
| 2011-09-11 | @ SEA | 148 | W 2-1 | 62-86 | 4 | 20,951 | Everett Teaford | Anthony Vasquez | Everett Teaford | Anthony Vasquez | Joakim Soria | 650 | 711 | -61 |
| 2011-09-13 | vs MIN | 149 | W 4-0 | 63-86 | 4 | 25,253 | Bruce Chen | Carl Pavano | Bruce Chen | Carl Pavano | | 654 | 711 | -57 |
| 2011-09-14 | vs MIN | 150 | W 7-3 | 64-86 | 4 | 19,076 | Luke Hochevar | Liam Hendriks | Luke Hochevar | Liam Hendriks | Greg Holland | 661 | 714 | -53 |
| 2011-09-15 | vs CHA | 151 | W 7-2 | 65-86 | 4 | 17,737 | Jeff Francis | Mark Buehrle | Jeff Francis | Mark Buehrle | | 668 | 716 | -48 |
| 2011-09-16 | vs CHA | 152 | W 7-6 | 66-86 | 4 | 24,918 | Felipe Paulino | Philip Humber | Greg Holland | Matt Thornton | | 675 | 722 | -47 |
| 2011-09-17 | vs CHA | 153 | W 10-3 | 67-86 | 4 | 31,264 | Everett Teaford | Zach Stewart | Everett Teaford | Zach Stewart | Nathan Adcock | 685 | 725 | -40 |
| 2011-09-18 | vs CHA | 154 | L 5-10 | 67-87 | 4 | 29,480 | Bruce Chen | John Danks | John Danks | Bruce Chen | | 690 | 735 | -45 |
| 2011-09-20 | vs DET | 155 | W 10-2 | 68-87 | 6 | 26,953 | Luis Mendoza | Brad Penny | Luis Mendoza | Brad Penny | | 700 | 737 | -37 |
| 2011-09-21 | vs DET | 156 | L 3-6 | 68-88 | 4 | 28,776 | Felipe Paulino | Max Scherzer | Doug Fister | Kelvin Herrera | Jose Valverde | 703 | 743 | -40 |
| 2011-09-23 | @ CHA | 157 | W 11-1 | 69-88 | 4 | 21,744 | Bruce Chen | Zach Stewart | Bruce Chen | Zach Stewart | | 714 | 744 | -30 |
| 2011-09-24 | @ CHA | 158 | L 3-6 | 69-89 | 5 | 26,249 | Everett Teaford | John Danks | John Danks | Everett Teaford | | 717 | 750 | -33 |
| 2011-09-25 | @ CHA | 159 | W 2-1 | 70-89 | 4 | 22,018 | Luis Mendoza | Gavin Floyd | Luis Mendoza | Gavin Floyd | Greg Holland | 719 | 751 | -32 |
| 2011-09-26 | @ MIN | 160 | W 7-3 | 71-89 | 4 | 34,847 | Felipe Paulino | Kevin Slowey | Felipe Paulino | Kevin Slowey | | 726 | 754 | -28 |
| 2011-09-27 | @ MIN | 161 | L 4-7 | 71-90 | 4 | 34,228 | Sean O'Sullivan | Anthony Swarzak | Anthony Swarzak | Sean O'Sullivan | | 730 | 761 | -31 |
| 2011-09-28 | @ MIN | 162 | L 0-1 | 71-91 | 4 | 36,488 | Bruce Chen | Carl Pavano | Carl Pavano | Blake Wood | | 730 | 762 | -32 |