| 2011-03-31 | @ KCA | 1 | W 4-2 | 1-0 | 1 | 40,055 | Jered Weaver | Luke Hochevar | Jered Weaver | Luke Hochevar | Fernando Rodney | 4 | 2 | 2 |
| 2011-04-01 | @ KCA | 2 | L 1-2 | 1-1 | 3 | 13,302 | Dan Haren | Jeff Francis | Joakim Soria | Michael Kohn | | 5 | 4 | 1 |
| 2011-04-02 | @ KCA | 3 | L 4-5 | 1-2 | 3 | 17,328 | Ervin Santana | Kyle Davies | Aaron Crow | Kevin Jepsen | Joakim Soria | 9 | 9 | 0 |
| 2011-04-03 | @ KCA | 4 | L 9-12 | 1-3 | 4 | 14,085 | Scott Kazmir | Bruce Chen | Tim Collins | Jason Bulger | | 18 | 21 | -3 |
| 2011-04-05 | @ TBA | 5 | W 5-3 | 2-3 | 2 | 13,173 | Jered Weaver | Jeff Niemann | Jered Weaver | Jeff Niemann | Jordan Walden | 23 | 24 | -1 |
| 2011-04-06 | @ TBA | 6 | W 5-1 | 3-3 | 2 | 11,836 | Dan Haren | Jeremy Hellickson | Dan Haren | Jeremy Hellickson | | 28 | 25 | 3 |
| 2011-04-08 | vs TOR | 7 | L 2-3 | 3-4 | 2 | 43,853 | Ervin Santana | Kyle Drabek | Octavio Dotel | Ervin Santana | Jon Rauch | 30 | 28 | 2 |
| 2011-04-09 | vs TOR | 8 | W 6-5 | 4-4 | 3 | 43,513 | Matt Palmer | Brett Cecil | Dan Haren | Jon Rauch | | 36 | 33 | 3 |
| 2011-04-10 | vs TOR | 9 | W 3-1 | 5-4 | 2 | 43,525 | Jered Weaver | Jo-Jo Reyes | Jered Weaver | Jo-Jo Reyes | Fernando Rodney | 39 | 34 | 5 |
| 2011-04-11 | vs CLE | 10 | L 0-4 | 5-5 | 2 | 32,864 | Tyler Chatwood | Mitch Talbot | Mitch Talbot | Tyler Chatwood | | 39 | 38 | 1 |
| 2011-04-12 | vs CLE | 11 | W 2-0 | 6-5 | 2 | 43,529 | Dan Haren | Fausto Carmona | Dan Haren | Fausto Carmona | | 41 | 38 | 3 |
| 2011-04-13 | vs CLE | 12 | W 4-3 | 7-5 | 2 | 31,049 | Ervin Santana | Carlos Carrasco | Hisanori Takahashi | Chad Durbin | | 45 | 41 | 4 |
| 2011-04-15 | @ CHA | 13 | W 4-3 | 8-5 | 2 | 20,103 | Jered Weaver | Philip Humber | Jered Weaver | Philip Humber | Jordan Walden | 49 | 44 | 5 |
| 2011-04-16 | @ CHA | 14 | W 7-2 | 9-5 | 2 | 21,250 | Tyler Chatwood | Gavin Floyd | Tyler Chatwood | Gavin Floyd | | 56 | 46 | 10 |
| 2011-04-17 | @ CHA | 15 | W 4-2 | 10-5 | 1 | 23,458 | Dan Haren | Mark Buehrle | Dan Haren | Mark Buehrle | Jordan Walden | 60 | 48 | 12 |
| 2011-04-18 | @ TEX | 16 | L 1-7 | 10-6 | 2 | 30,799 | Ervin Santana | C.J. Wilson | C.J. Wilson | Ervin Santana | | 61 | 55 | 6 |
| 2011-04-19 | @ TEX | 17 | W 15-4 | 11-6 | 1 | 22,450 | Matt Palmer | Colby Lewis | Matt Palmer | Colby Lewis | | 76 | 59 | 17 |
| 2011-04-20 | @ TEX | 18 | W 4-1 | 12-6 | 1 | 31,967 | Jered Weaver | Matt Harrison | Jered Weaver | Matt Harrison | | 80 | 60 | 20 |
| 2011-04-21 | vs BOS | 19 | L 2-4 | 12-7 | 1 | 37,003 | Tyler Chatwood | Josh Beckett | Bobby Jenks | Rich Thompson | Jonathan Papelbon | 82 | 64 | 18 |
| 2011-04-22 | vs BOS | 20 | L 3-4 | 12-8 | 2 | 39,005 | Dan Haren | Jon Lester | Jon Lester | Dan Haren | Jonathan Papelbon | 85 | 68 | 17 |
| 2011-04-23 | vs BOS | 21 | L 0-5 | 12-9 | 2 | 40,025 | Ervin Santana | Daisuke Matsuzaka | Daisuke Matsuzaka | Ervin Santana | | 85 | 73 | 12 |
| 2011-04-24 | vs BOS | 22 | L 0-7 | 12-10 | 2 | 35,107 | Matt Palmer | John Lackey | John Lackey | Matt Palmer | | 85 | 80 | 5 |
| 2011-04-25 | vs OAK | 23 | W 5-0 | 13-10 | 2 | 37,115 | Jered Weaver | Gio Gonzalez | Jered Weaver | Gio Gonzalez | | 90 | 80 | 10 |
| 2011-04-26 | vs OAK | 24 | W 8-3 | 14-10 | 2 | 37,228 | Tyler Chatwood | Brandon McCarthy | Tyler Chatwood | Brandon McCarthy | | 98 | 83 | 15 |
| 2011-04-27 | vs OAK | 25 | L 1-2 | 14-11 | 2 | 37,247 | Dan Haren | Tyson Ross | Brian Fuentes | Jordan Walden | Brad Ziegler | 99 | 85 | 14 |
| 2011-04-29 | @ TBA | 26 | W 8-5 | 15-11 | 1 | 21,791 | Ervin Santana | David Price | Ervin Santana | David Price | Jordan Walden | 107 | 90 | 17 |
| 2011-04-30 | @ TBA | 27 | L 1-2 | 15-12 | 2 | 20,245 | Joel Pineiro | James Shields | Joel Peralta | Fernando Rodney | | 108 | 92 | 16 |
| 2011-05-01 | @ TBA | 28 | W 6-5 | 16-12 | 1 | 16,248 | Tyler Chatwood | Alex Cobb | Rich Thompson | Joel Peralta | Jordan Walden | 114 | 97 | 17 |
| 2011-05-02 | @ BOS | 29 | L 5-9 | 16-13 | 1 | 37,017 | Jered Weaver | Clay Buchholz | Clay Buchholz | Jered Weaver | | 119 | 106 | 13 |
| 2011-05-03 | @ BOS | 30 | L 3-7 | 16-14 | 1 | 37,043 | Dan Haren | Jon Lester | Jon Lester | Dan Haren | | 122 | 113 | 9 |
| 2011-05-04 | @ BOS | 31 | W 5-3 | 17-14 | 1 | 37,037 | Ervin Santana | Josh Beckett | Trevor Bell | Daisuke Matsuzaka | | 127 | 116 | 11 |
| 2011-05-05 | @ BOS | 32 | W 11-0 | 18-14 | 1 | 37,013 | Joel Pineiro | John Lackey | Joel Pineiro | John Lackey | | 138 | 116 | 22 |
| 2011-05-06 | vs CLE | 33 | W 2-1 | 19-14 | 1 | 36,447 | Tyler Chatwood | Justin Masterson | Fernando Rodney | Justin Germano | | 140 | 117 | 23 |
| 2011-05-07 | vs CLE | 34 | L 3-4 | 19-15 | 1 | 37,684 | Jered Weaver | Alex White | Alex White | Jered Weaver | Chris Perez | 143 | 121 | 22 |
| 2011-05-08 | vs CLE | 35 | W 6-5 | 20-15 | 1 | 40,124 | Dan Haren | Fausto Carmona | Fernando Rodney | Joe Smith | Jordan Walden | 149 | 126 | 23 |
| 2011-05-09 | vs CHA | 36 | L 0-8 | 20-16 | 1 | 38,561 | Ervin Santana | Edwin Jackson | Edwin Jackson | Ervin Santana | | 149 | 134 | 15 |
| 2011-05-10 | vs CHA | 37 | W 6-2 | 21-16 | 1 | 40,128 | Joel Pineiro | John Danks | Joel Pineiro | John Danks | | 155 | 136 | 19 |
| 2011-05-11 | vs CHA | 38 | L 4-6 | 21-17 | 1 | 39,151 | Tyler Chatwood | Jake Peavy | Sergio Santos | Kevin Jepsen | Matt Thornton | 159 | 142 | 17 |
| 2011-05-13 | @ TEX | 39 | L 1-4 | 21-18 | 1 | 45,995 | Jered Weaver | Alexi Ogando | Alexi Ogando | Jered Weaver | Neftali Feliz | 160 | 146 | 14 |
| 2011-05-14 | @ TEX | 40 | W 3-2 | 22-18 | 1 | 47,663 | Dan Haren | Derek Holland | Scott Downs | Darren Oliver | Jordan Walden | 163 | 148 | 15 |
| 2011-05-15 | @ TEX | 41 | L 4-5 | 22-19 | 1 | 48,284 | Ervin Santana | C.J. Wilson | Mark Lowe | Rich Thompson | Neftali Feliz | 167 | 153 | 14 |
| 2011-05-16 | @ OAK | 42 | L 4-5 | 22-20 | 2 | 11,061 | Joel Pineiro | Brett Anderson | Grant Balfour | Fernando Rodney | | 171 | 158 | 13 |
| 2011-05-17 | @ OAK | 43 | L 0-14 | 22-21 | 3 | 12,190 | Tyler Chatwood | Gio Gonzalez | Gio Gonzalez | Tyler Chatwood | | 171 | 172 | -1 |
| 2011-05-18 | @ SEA | 44 | L 0-3 | 22-22 | 3 | 16,992 | Jered Weaver | Jason Vargas | Jason Vargas | Jered Weaver | Brandon League | 171 | 175 | -4 |
| 2011-05-19 | @ SEA | 45 | L 1-2 | 22-23 | 3 | 18,374 | Dan Haren | Doug Fister | David Pauley | Scott Downs | | 172 | 177 | -5 |
| 2011-05-20 | vs ATL | 46 | W 9-0 | 23-23 | 2 | 40,211 | Ervin Santana | Tim Hudson | Ervin Santana | Tim Hudson | | 181 | 177 | 4 |
| 2011-05-21 | vs ATL | 47 | L 4-5 | 23-24 | 2 | 43,511 | Joel Pineiro | Tommy Hanson | Scott Proctor | Trevor Bell | Craig Kimbrel | 185 | 182 | 3 |
| 2011-05-22 | vs ATL | 48 | W 4-1 | 24-24 | 2 | 40,098 | Tyler Chatwood | Derek Lowe | Tyler Chatwood | Derek Lowe | Jordan Walden | 189 | 183 | 6 |
| 2011-05-23 | vs OAK | 49 | W 4-1 | 25-24 | 2 | 36,215 | Jered Weaver | Josh Outman | Scott Downs | Brian Fuentes | Jordan Walden | 193 | 184 | 9 |
| 2011-05-24 | vs OAK | 50 | L 1-6 | 25-25 | 2 | 39,117 | Dan Haren | Guillermo Moscoso | Guillermo Moscoso | Dan Haren | | 194 | 190 | 4 |
| 2011-05-25 | vs OAK | 51 | W 4-1 | 26-25 | 2 | 40,253 | Ervin Santana | Trevor Cahill | Ervin Santana | Trevor Cahill | Jordan Walden | 198 | 191 | 7 |
| 2011-05-26 | vs OAK | 52 | L 3-4 | 26-26 | 2 | 33,412 | Joel Pineiro | Brett Anderson | Brett Anderson | Joel Pineiro | | 201 | 195 | 6 |
| 2011-05-27 | @ MIN | 53 | W 6-5 | 27-26 | 2 | 38,976 | Tyler Chatwood | Scott Baker | Scott Downs | Jim Hoey | Jordan Walden | 207 | 200 | 7 |
| 2011-05-28 | @ MIN | 54 | L 0-1 | 27-27 | 3 | 39,824 | Jered Weaver | Anthony Swarzak | Alex Burnett | Hisanori Takahashi | | 207 | 201 | 6 |
| 2011-05-29 | @ MIN | 55 | W 6-5 | 28-27 | 2 | 39,867 | Dan Haren | Carl Pavano | Dan Haren | Carl Pavano | Jordan Walden | 213 | 206 | 7 |
| 2011-05-30 | @ KCA | 56 | W 10-8 | 29-27 | 2 | 24,406 | Ervin Santana | Luke Hochevar | Kevin Jepsen | Joakim Soria | Fernando Rodney | 223 | 214 | 9 |
| 2011-05-31 | @ KCA | 57 | L 3-7 | 29-28 | 3 | 14,174 | Joel Pineiro | Jeff Francis | Jeff Francis | Joel Pineiro | | 226 | 221 | 5 |
| 2011-06-01 | @ KCA | 58 | L 0-2 | 29-29 | 3 | 12,022 | Tyler Chatwood | Felipe Paulino | Tim Collins | Scott Downs | | 226 | 223 | 3 |
| 2011-06-03 | vs NYA | 59 | W 3-2 | 30-29 | 3 | 42,521 | Jered Weaver | Ivan Nova | Jered Weaver | Ivan Nova | Jordan Walden | 229 | 225 | 4 |
| 2011-06-04 | vs NYA | 60 | L 2-3 | 30-30 | 3 | 43,619 | Ervin Santana | CC Sabathia | CC Sabathia | Ervin Santana | Mariano Rivera | 231 | 228 | 3 |
| 2011-06-05 | vs NYA | 61 | L 3-5 | 30-31 | 3 | 43,524 | Joel Pineiro | Bartolo Colon | Bartolo Colon | Joel Pineiro | Mariano Rivera | 234 | 233 | 1 |
| 2011-06-06 | vs TBA | 62 | L 1-5 | 30-32 | 3 | 32,287 | Tyler Chatwood | David Price | David Price | Tyler Chatwood | | 235 | 238 | -3 |
| 2011-06-07 | vs TBA | 63 | L 1-4 | 30-33 | 3 | 38,833 | Dan Haren | Alex Cobb | Alex Cobb | Dan Haren | Kyle Farnsworth | 236 | 242 | -6 |
| 2011-06-08 | vs TBA | 64 | L 3-4 | 30-34 | 3 | 33,157 | Jered Weaver | James Shields | Juan Cruz | Fernando Rodney | Kyle Farnsworth | 239 | 246 | -7 |
| 2011-06-10 | vs KCA | 65 | L 2-4 | 30-35 | 3 | 38,254 | Ervin Santana | Jeff Francis | Jeff Francis | Ervin Santana | Joakim Soria | 241 | 250 | -9 |
| 2011-06-11 | vs KCA | 66 | W 7-5 | 31-35 | 3 | 38,911 | Joel Pineiro | Felipe Paulino | Scott Downs | Tim Collins | Jordan Walden | 248 | 255 | -7 |
| 2011-06-12 | vs KCA | 67 | L 0-9 | 31-36 | 3 | 39,114 | Tyler Chatwood | Vin Mazzaro | Vin Mazzaro | Tyler Chatwood | | 248 | 264 | -16 |
| 2011-06-13 | @ SEA | 68 | W 6-3 | 32-36 | 3 | 20,238 | Dan Haren | Jason Vargas | Dan Haren | Jason Vargas | Jordan Walden | 254 | 267 | -13 |
| 2011-06-14 | @ SEA | 69 | W 4-0 | 33-36 | 3 | 17,634 | Jered Weaver | Doug Fister | Jered Weaver | Doug Fister | | 258 | 267 | -9 |
| 2011-06-15 | @ SEA | 70 | L 1-3 | 33-37 | 3 | 19,321 | Ervin Santana | Erik Bedard | Erik Bedard | Ervin Santana | Brandon League | 259 | 270 | -11 |
| 2011-06-17 | @ NYN | 71 | W 4-3 | 34-37 | 3 | 29,513 | Joel Pineiro | Chris Capuano | Joel Pineiro | Chris Capuano | Jordan Walden | 263 | 273 | -10 |
| 2011-06-18 | @ NYN | 72 | L 1-6 | 34-38 | 3 | 31,538 | Dan Haren | Mike Pelfrey | Mike Pelfrey | Dan Haren | | 264 | 279 | -15 |
| 2011-06-19 | @ NYN | 73 | W 7-3 | 35-38 | 3 | 36,213 | Tyler Chatwood | Jonathon Niese | Tyler Chatwood | Jonathon Niese | | 271 | 282 | -11 |
| 2011-06-20 | @ FLO | 74 | W 2-1 | 36-38 | 3 | 16,984 | Jered Weaver | Anibal Sanchez | Jered Weaver | Steve Cishek | Jordan Walden | 273 | 283 | -10 |
| 2011-06-21 | @ FLO | 75 | L 2-5 | 36-39 | 3 | 17,344 | Ervin Santana | Javier Vazquez | Javier Vazquez | Ervin Santana | Leo Nunez | 275 | 288 | -13 |
| 2011-06-22 | @ FLO | 76 | W 6-5 | 37-39 | 3 | 19,721 | Joel Pineiro | Brian Sanches | Jordan Walden | Burke Badenhop | Michael Kohn | 281 | 293 | -12 |
| 2011-06-24 | @ LAN | 77 | W 8-3 | 38-39 | 3 | 43,640 | Dan Haren | Rubby de la Rosa | Dan Haren | Rubby de la Rosa | | 289 | 296 | -7 |
| 2011-06-25 | @ LAN | 78 | W 6-1 | 39-39 | 2 | 41,108 | Tyler Chatwood | Hiroki Kuroda | Tyler Chatwood | Hiroki Kuroda | | 295 | 297 | -2 |
| 2011-06-26 | @ LAN | 79 | L 2-3 | 39-40 | 3 | 43,104 | Jered Weaver | Clayton Kershaw | Clayton Kershaw | Jordan Walden | | 297 | 300 | -3 |
| 2011-06-27 | vs WAS | 80 | W 4-3 | 40-40 | 2 | 35,032 | Ervin Santana | John Lannan | Scott Downs | Sean Burnett | | 301 | 303 | -2 |
| 2011-06-28 | vs WAS | 81 | W 11-5 | 41-40 | 2 | 41,029 | Joel Pineiro | Jason Marquis | Hisanori Takahashi | Collin Balester | | 312 | 308 | 4 |
| 2011-06-29 | vs WAS | 82 | W 1-0 | 42-40 | 2 | 35,257 | Dan Haren | Jordan Zimmermann | Dan Haren | Jordan Zimmermann | Jordan Walden | 313 | 308 | 5 |
| 2011-07-01 | vs LAN | 83 | L 0-5 | 42-41 | 2 | 41,253 | Tyler Chatwood | Hiroki Kuroda | Hiroki Kuroda | Tyler Chatwood | | 313 | 313 | 0 |
| 2011-07-02 | vs LAN | 84 | W 7-1 | 43-41 | 2 | 42,232 | Jered Weaver | Clayton Kershaw | Jered Weaver | Clayton Kershaw | | 320 | 314 | 6 |
| 2011-07-03 | vs LAN | 85 | W 3-1 | 44-41 | 1 | 42,536 | Ervin Santana | Chad Billingsley | Ervin Santana | Chad Billingsley | Jordan Walden | 323 | 315 | 8 |
| 2011-07-04 | vs DET | 86 | W 5-1 | 45-41 | 1 | 43,012 | Joel Pineiro | Charlie Furbush | Joel Pineiro | Charlie Furbush | | 328 | 316 | 12 |
| 2011-07-05 | vs DET | 87 | W 1-0 | 46-41 | 1 | 39,006 | Dan Haren | Justin Verlander | Dan Haren | Justin Verlander | | 329 | 316 | 13 |
| 2011-07-06 | vs DET | 88 | L 4-5 | 46-42 | 2 | 31,549 | Tyler Chatwood | Brad Penny | Brad Penny | Hisanori Takahashi | Jose Valverde | 333 | 321 | 12 |
| 2011-07-07 | vs SEA | 89 | W 5-1 | 47-42 | 2 | 41,223 | Jered Weaver | Doug Fister | Jered Weaver | Doug Fister | | 338 | 322 | 16 |
| 2011-07-08 | vs SEA | 90 | W 4-3 | 48-42 | 2 | 40,161 | Ervin Santana | Blake Beavan | Jordan Walden | David Pauley | | 342 | 325 | 17 |
| 2011-07-09 | vs SEA | 91 | W 9-3 | 49-42 | 2 | 44,111 | Joel Pineiro | Michael Pineda | Joel Pineiro | Michael Pineda | | 351 | 328 | 23 |
| 2011-07-10 | vs SEA | 92 | W 4-2 | 50-42 | 2 | 39,505 | Dan Haren | Felix Hernandez | Dan Haren | David Pauley | Jordan Walden | 355 | 330 | 25 |
| 2011-07-15 | @ OAK | 93 | L 3-5 | 50-43 | 2 | 18,470 | Dan Haren | Brandon McCarthy | Brandon McCarthy | Dan Haren | Andrew Bailey | 358 | 335 | 23 |
| 2011-07-16 | @ OAK | 94 | W 4-2 | 51-44 | 3 | 0 | Jered Weaver | Trevor Cahill | Jered Weaver | Trevor Cahill | Jordan Walden | 362 | 337 | 25 |
| 2011-07-16 | @ OAK | 95 | L 3-4 | 51-44 | 3 | 27,379 | Ervin Santana | Rich Harden | Brad Ziegler | Rich Thompson | | 365 | 341 | 24 |
| 2011-07-17 | @ OAK | 96 | L 1-9 | 51-45 | 2 | 26,115 | Joel Pineiro | Gio Gonzalez | Gio Gonzalez | Joel Pineiro | | 366 | 350 | 16 |
| 2011-07-19 | vs TEX | 97 | L 0-7 | 51-46 | 2 | 43,103 | Tyler Chatwood | Alexi Ogando | Alexi Ogando | Tyler Chatwood | | 366 | 357 | 9 |
| 2011-07-20 | vs TEX | 98 | W 9-8 | 52-46 | 2 | 40,052 | Dan Haren | Derek Holland | Hisanori Takahashi | Tommy Hunter | Jordan Walden | 375 | 365 | 10 |
| 2011-07-21 | vs TEX | 99 | W 1-0 | 53-46 | 2 | 38,315 | Jered Weaver | C.J. Wilson | Jered Weaver | C.J. Wilson | Jordan Walden | 376 | 365 | 11 |
| 2011-07-22 | @ BAL | 100 | W 6-1 | 54-46 | 2 | 24,823 | Ervin Santana | Alfredo Simon | Ervin Santana | Alfredo Simon | Hisanori Takahashi | 382 | 366 | 16 |
| 2011-07-23 | @ BAL | 101 | L 2-3 | 54-47 | 2 | 20,311 | Joel Pineiro | Brad Bergesen | Brad Bergesen | Joel Pineiro | Kevin Gregg | 384 | 369 | 15 |
| 2011-07-24 | @ BAL | 102 | W 9-3 | 55-47 | 2 | 15,676 | Tyler Chatwood | Jeremy Guthrie | Tyler Chatwood | Jeremy Guthrie | | 393 | 372 | 21 |
| 2011-07-25 | @ CLE | 103 | L 2-3 | 55-48 | 2 | 19,384 | Dan Haren | Fausto Carmona | Tony Sipp | Jordan Walden | | 395 | 375 | 20 |
| 2011-07-26 | @ CLE | 104 | W 2-1 | 56-48 | 2 | 19,430 | Jered Weaver | Josh Tomlin | Jered Weaver | Josh Tomlin | Jordan Walden | 397 | 376 | 21 |
| 2011-07-27 | @ CLE | 105 | W 3-1 | 57-48 | 2 | 21,546 | Ervin Santana | David Huff | Ervin Santana | David Huff | | 400 | 377 | 23 |
| 2011-07-28 | @ DET | 106 | W 12-7 | 58-48 | 2 | 33,489 | Joel Pineiro | Brad Penny | Bobby Cassevah | Brad Penny | | 412 | 384 | 28 |
| 2011-07-29 | @ DET | 107 | L 2-12 | 58-49 | 2 | 40,551 | Tyler Chatwood | Rick Porcello | Rick Porcello | Tyler Chatwood | | 414 | 396 | 18 |
| 2011-07-30 | @ DET | 108 | W 5-1 | 59-49 | 2 | 40,753 | Dan Haren | Jacob Turner | Dan Haren | Jacob Turner | | 419 | 397 | 22 |
| 2011-07-31 | @ DET | 109 | L 2-3 | 59-50 | 2 | 36,878 | Jered Weaver | Justin Verlander | Justin Verlander | Jered Weaver | Jose Valverde | 421 | 400 | 21 |
| 2011-08-02 | vs MIN | 110 | W 5-1 | 60-50 | 2 | 37,565 | Ervin Santana | Brian Duensing | Ervin Santana | Brian Duensing | | 426 | 401 | 25 |
| 2011-08-03 | vs MIN | 111 | L 4-11 | 60-51 | 2 | 35,555 | Joel Pineiro | Scott Baker | Anthony Swarzak | Joel Pineiro | | 430 | 412 | 18 |
| 2011-08-04 | vs MIN | 112 | W 7-1 | 61-51 | 2 | 40,365 | Dan Haren | Francisco Liriano | Dan Haren | Francisco Liriano | | 437 | 413 | 24 |
| 2011-08-05 | vs SEA | 113 | W 1-0 | 62-51 | 2 | 38,727 | Jered Weaver | Jason Vargas | Jordan Walden | Dan Cortes | | 438 | 413 | 25 |
| 2011-08-06 | vs SEA | 114 | L 1-5 | 62-52 | 2 | 42,017 | Tyler Chatwood | Blake Beavan | Blake Beavan | Tyler Chatwood | | 439 | 418 | 21 |
| 2011-08-07 | vs SEA | 115 | W 2-1 | 63-52 | 2 | 38,823 | Ervin Santana | Felix Hernandez | Ervin Santana | Felix Hernandez | Jordan Walden | 441 | 419 | 22 |
| 2011-08-09 | @ NYA | 116 | W 6-4 | 64-52 | 2 | 46,466 | Dan Haren | A.J. Burnett | Scott Downs | Mariano Rivera | Jordan Walden | 447 | 423 | 24 |
| 2011-08-10 | @ NYA | 117 | L 3-9 | 64-53 | 2 | 46,967 | Garrett Richards | Ivan Nova | Ivan Nova | Garrett Richards | | 450 | 432 | 18 |
| 2011-08-11 | @ NYA | 118 | L 5-6 | 64-54 | 2 | 47,431 | Tyler Chatwood | Bartolo Colon | Rafael Soriano | Fernando Rodney | Mariano Rivera | 455 | 438 | 17 |
| 2011-08-12 | @ TOR | 119 | W 5-1 | 65-54 | 2 | 24,731 | Ervin Santana | Brandon Morrow | Ervin Santana | Brandon Morrow | | 460 | 439 | 21 |
| 2011-08-13 | @ TOR | 120 | L 2-11 | 65-55 | 2 | 27,185 | Jered Weaver | Ricky Romero | Ricky Romero | Jered Weaver | | 462 | 450 | 12 |
| 2011-08-14 | @ TOR | 121 | L 4-5 | 65-56 | 2 | 23,355 | Dan Haren | Brett Cecil | Jon Rauch | Fernando Rodney | | 466 | 455 | 11 |
| 2011-08-15 | vs TEX | 122 | L 4-8 | 65-57 | 2 | 36,663 | Garrett Richards | Alexi Ogando | Alexi Ogando | Bobby Cassevah | | 470 | 463 | 7 |
| 2011-08-16 | vs TEX | 123 | L 3-7 | 65-58 | 2 | 43,711 | Tyler Chatwood | Derek Holland | Derek Holland | Tyler Chatwood | | 473 | 470 | 3 |
| 2011-08-17 | vs TEX | 124 | L 3-4 | 65-59 | 2 | 36,581 | Ervin Santana | C.J. Wilson | C.J. Wilson | Ervin Santana | Neftali Feliz | 476 | 474 | 2 |
| 2011-08-18 | vs TEX | 125 | W 2-1 | 66-59 | 2 | 41,123 | Jered Weaver | Colby Lewis | Horacio Ramirez | Mike Adams | | 478 | 475 | 3 |
| 2011-08-19 | vs BAL | 126 | W 8-3 | 67-59 | 2 | 38,156 | Dan Haren | Jo-Jo Reyes | Dan Haren | Jo-Jo Reyes | | 486 | 478 | 8 |
| 2011-08-20 | vs BAL | 127 | W 9-8 | 68-59 | 2 | 43,201 | Joel Pineiro | Tommy Hunter | Fernando Rodney | Kevin Gregg | | 495 | 486 | 9 |
| 2011-08-21 | vs BAL | 128 | W 7-1 | 69-59 | 2 | 37,148 | Jerome Williams | Brian Matusz | Jerome Williams | Brian Matusz | | 502 | 487 | 15 |
| 2011-08-23 | vs CHA | 129 | W 5-4 | 70-59 | 2 | 37,728 | Ervin Santana | Mark Buehrle | Jordan Walden | Jason Frasor | | 507 | 491 | 16 |
| 2011-08-24 | vs CHA | 130 | W 8-0 | 71-59 | 2 | 36,610 | Jered Weaver | Zach Stewart | Jered Weaver | Zach Stewart | | 515 | 491 | 24 |
| 2011-08-26 | @ TEX | 131 | L 7-11 | 71-60 | 2 | 38,256 | Dan Haren | Derek Holland | Derek Holland | Dan Haren | | 522 | 502 | 20 |
| 2011-08-27 | @ TEX | 132 | W 8-4 | 72-60 | 2 | 48,453 | Ervin Santana | C.J. Wilson | Ervin Santana | C.J. Wilson | Hisanori Takahashi | 530 | 506 | 24 |
| 2011-08-28 | @ TEX | 133 | L 5-9 | 72-61 | 2 | 40,018 | Jered Weaver | Colby Lewis | Darren Oliver | Jered Weaver | | 535 | 515 | 20 |
| 2011-08-29 | @ SEA | 134 | L 3-5 | 72-62 | 2 | 16,990 | Joel Pineiro | Blake Beavan | Tom Wilhelmsen | Hisanori Takahashi | Brandon League | 538 | 520 | 18 |
| 2011-08-30 | @ SEA | 135 | W 13-6 | 73-62 | 2 | 15,536 | Jerome Williams | Anthony Vasquez | Jerome Williams | Anthony Vasquez | | 551 | 526 | 25 |
| 2011-08-31 | @ SEA | 136 | L 1-2 | 73-63 | 2 | 18,520 | Dan Haren | Felix Hernandez | Felix Hernandez | Dan Haren | | 552 | 528 | 24 |
| 2011-09-01 | @ SEA | 137 | W 4-3 | 74-63 | 2 | 19,453 | Ervin Santana | Charlie Furbush | Ervin Santana | Charlie Furbush | Jordan Walden | 556 | 531 | 25 |
| 2011-09-02 | vs MIN | 138 | L 5-13 | 74-64 | 2 | 37,198 | Tyler Chatwood | Carl Pavano | Carl Pavano | Tyler Chatwood | | 561 | 544 | 17 |
| 2011-09-03 | vs MIN | 139 | W 10-6 | 75-64 | 2 | 39,102 | Jered Weaver | Brian Duensing | Jered Weaver | Phil Dumatrait | | 571 | 550 | 21 |
| 2011-09-04 | vs MIN | 140 | W 4-1 | 76-64 | 2 | 36,638 | Joel Pineiro | Kevin Slowey | Joel Pineiro | Kevin Slowey | Jordan Walden | 575 | 551 | 24 |
| 2011-09-05 | vs SEA | 141 | W 7-3 | 77-64 | 2 | 35,497 | Dan Haren | Anthony Vasquez | Dan Haren | Anthony Vasquez | | 582 | 554 | 28 |
| 2011-09-06 | vs SEA | 142 | L 1-2 | 77-65 | 2 | 36,533 | Ervin Santana | Felix Hernandez | Felix Hernandez | Ervin Santana | Brandon League | 583 | 556 | 27 |
| 2011-09-07 | vs SEA | 143 | W 3-1 | 78-65 | 2 | 37,459 | Jerome Williams | Charlie Furbush | Jerome Williams | Charlie Furbush | Jordan Walden | 586 | 557 | 29 |
| 2011-09-09 | vs NYA | 144 | W 2-1 | 79-65 | 2 | 41,014 | Jered Weaver | Bartolo Colon | Jordan Walden | Aaron Laffey | | 588 | 558 | 30 |
| 2011-09-10 | vs NYA | 145 | W 6-0 | 80-65 | 2 | 42,774 | Dan Haren | CC Sabathia | Dan Haren | CC Sabathia | | 594 | 558 | 36 |
| 2011-09-11 | vs NYA | 146 | L 5-6 | 80-66 | 2 | 42,581 | Ervin Santana | Freddy Garcia | Cory Wade | Ervin Santana | Mariano Rivera | 599 | 564 | 35 |
| 2011-09-12 | @ OAK | 147 | L 3-6 | 80-67 | 2 | 12,858 | Joel Pineiro | Gio Gonzalez | Gio Gonzalez | Joel Pineiro | | 602 | 570 | 32 |
| 2011-09-13 | @ OAK | 148 | W 6-3 | 81-67 | 2 | 13,212 | Jerome Williams | Guillermo Moscoso | Hisanori Takahashi | Fautino de los Santos | Jordan Walden | 608 | 573 | 35 |
| 2011-09-14 | @ OAK | 149 | W 4-1 | 82-67 | 2 | 14,743 | Jered Weaver | Rich Harden | Jered Weaver | Rich Harden | Jordan Walden | 612 | 574 | 38 |
| 2011-09-16 | @ BAL | 150 | L 3-8 | 82-68 | 2 | 24,022 | Dan Haren | Tommy Hunter | Tommy Hunter | Dan Haren | | 615 | 582 | 33 |
| 2011-09-17 | @ BAL | 151 | L 2-6 | 82-69 | 2 | 31,099 | Ervin Santana | Zachary Britton | Zachary Britton | Ervin Santana | | 617 | 588 | 29 |
| 2011-09-18 | @ BAL | 152 | W 11-2 | 83-69 | 2 | 27,471 | Jered Weaver | Alfredo Simon | Jered Weaver | Alfredo Simon | | 628 | 590 | 38 |
| 2011-09-19 | @ TOR | 153 | L 2-3 | 83-70 | 2 | 11,178 | Jerome Williams | Ricky Romero | Casey Janssen | Scott Downs | | 630 | 593 | 37 |
| 2011-09-20 | @ TOR | 154 | W 10-6 | 84-70 | 2 | 13,514 | Joel Pineiro | Brett Cecil | Joel Pineiro | Brett Cecil | Scott Downs | 640 | 599 | 41 |
| 2011-09-21 | @ TOR | 155 | W 7-2 | 85-70 | 2 | 14,784 | Dan Haren | Dustin McGowan | Dan Haren | Dustin McGowan | | 647 | 601 | 46 |
| 2011-09-22 | @ TOR | 156 | L 3-4 | 85-71 | 2 | 22,769 | Ervin Santana | Henderson Alvarez | Shawn Camp | Garrett Richards | | 650 | 605 | 45 |
| 2011-09-23 | vs OAK | 157 | L 1-3 | 85-72 | 2 | 39,217 | Jered Weaver | Gio Gonzalez | Gio Gonzalez | Jered Weaver | Andrew Bailey | 651 | 608 | 43 |
| 2011-09-24 | vs OAK | 158 | W 4-2 | 86-72 | 2 | 41,113 | Jerome Williams | Guillermo Moscoso | Jerome Williams | Guillermo Moscoso | Jordan Walden | 655 | 610 | 45 |
| 2011-09-25 | vs OAK | 159 | L 5-6 | 86-73 | 2 | 40,794 | Joel Pineiro | Rich Harden | Fautino de los Santos | Jordan Walden | Andrew Bailey | 660 | 616 | 44 |
| 2011-09-26 | vs TEX | 160 | L 3-4 | 86-74 | 2 | 39,716 | Dan Haren | C.J. Wilson | Mark Hamburger | Dan Haren | Neftali Feliz | 663 | 620 | 43 |
| 2011-09-27 | vs TEX | 161 | L 3-10 | 86-75 | 2 | 39,529 | Tyler Chatwood | Colby Lewis | Colby Lewis | Tyler Chatwood | | 666 | 630 | 36 |
| 2011-09-28 | vs TEX | 162 | L 1-3 | 86-76 | 2 | 39,612 | Garrett Richards | Matt Harrison | Mike Adams | Jordan Walden | Neftali Feliz | 667 | 633 | 34 |