| 2010-04-05 | vs PHI | 1 | L 1-11 | 0-1 | 5 | 41,290 | John Lannan | Roy Halladay | Roy Halladay | John Lannan | | 1 | 11 | -10 |
| 2010-04-07 | vs PHI | 2 | L 4-8 | 0-2 | 5 | 27,240 | Jason Marquis | Cole Hamels | Cole Hamels | Jason Marquis | Ryan Madson | 5 | 19 | -14 |
| 2010-04-08 | vs PHI | 3 | W 6-5 | 1-2 | 5 | 20,217 | Craig Stammen | Kyle Kendrick | Tyler Clippard | Nelson Figueroa | Matt Capps | 11 | 24 | -13 |
| 2010-04-09 | @ NYN | 4 | L 2-8 | 1-3 | 5 | 28,055 | Garrett Mock | Mike Pelfrey | Mike Pelfrey | Miguel Batista | | 13 | 32 | -19 |
| 2010-04-10 | @ NYN | 5 | W 4-3 | 2-3 | 5 | 33,044 | John Lannan | Oliver Perez | John Lannan | Oliver Perez | Matt Capps | 17 | 35 | -18 |
| 2010-04-11 | @ NYN | 6 | W 5-2 | 3-3 | 3 | 33,672 | Livan Hernandez | Johan Santana | Livan Hernandez | Johan Santana | Matt Capps | 22 | 37 | -15 |
| 2010-04-12 | @ PHI | 7 | L 4-7 | 3-4 | 4 | 44,791 | Jason Marquis | Cole Hamels | Cole Hamels | Jason Marquis | Ryan Madson | 26 | 44 | -18 |
| 2010-04-14 | @ PHI | 8 | L 7-14 | 4-4 | 4 | 45,438 | Craig Stammen | Kyle Kendrick | Nelson Figueroa | Jason Bergmann | | 33 | 58 | -25 |
| 2010-04-15 | @ PHI | 9 | W 7-5 | 5-4 | 4 | 44,157 | Scott Olsen | J.A. Happ | Tyler Clippard | Danys Baez | Matt Capps | 40 | 63 | -23 |
| 2010-04-16 | vs MIL | 10 | W 5-3 | 6-4 | 3 | 17,234 | John Lannan | Yovani Gallardo | Brian Bruney | LaTroy Hawkins | Matt Capps | 45 | 66 | -21 |
| 2010-04-17 | vs MIL | 11 | W 8-0 | 7-4 | 2 | 18,673 | Livan Hernandez | Randy Wolf | Livan Hernandez | Randy Wolf | | 53 | 66 | -13 |
| 2010-04-18 | vs MIL | 12 | L 7-11 | 8-4 | 1 | 18,789 | Jason Marquis | Doug Davis | Claudio Vargas | Jason Marquis | | 60 | 77 | -17 |
| 2010-04-19 | vs COL | 13 | W 5-2 | 9-4 | 1 | 11,623 | Craig Stammen | Aaron Cook | Craig Stammen | Aaron Cook | Matt Capps | 65 | 79 | -14 |
| 2010-04-20 | vs COL | 14 | L 4-10 | 10-4 | 1 | 15,037 | Scott Olsen | Jorge de la Rosa | Jorge de la Rosa | Scott Olsen | | 69 | 89 | -20 |
| 2010-04-21 | vs COL | 15 | W 6-4 | 11-4 | 1 | 11,191 | John Lannan | Jason Hammel | Tyler Clippard | Rafael Betancourt | Matt Capps | 75 | 93 | -18 |
| 2010-04-22 | vs COL | 16 | L 0-2 | 11-5 | 1 | 15,518 | Livan Hernandez | Ubaldo Jimenez | Ubaldo Jimenez | Livan Hernandez | Franklin Morales | 75 | 95 | -20 |
| 2010-04-23 | vs LAN | 17 | W 5-1 | 12-5 | 1 | 23,859 | Luis Atilano | Charlie Haeger | Luis Atilano | Charlie Haeger | | 80 | 96 | -16 |
| 2010-04-24 | vs LAN | 18 | L 3-4 | 12-6 | 1 | 18,039 | Craig Stammen | Clayton Kershaw | Carlos Monasterios | Miguel Batista | | 83 | 100 | -17 |
| 2010-04-25 | vs LAN | 19 | W 1-0 | 13-6 | 1 | 18,395 | Scott Olsen | Chad Billingsley | Scott Olsen | Chad Billingsley | Matt Capps | 84 | 100 | -16 |
| 2010-04-26 | @ CHN | 20 | L 3-4 | 13-7 | 1 | 37,850 | John Lannan | Carlos Silva | Carlos Marmol | Brian Bruney | | 87 | 104 | -17 |
| 2010-04-27 | @ CHN | 21 | W 3-1 | 14-7 | 1 | 37,440 | Livan Hernandez | Tom Gorzelanny | Livan Hernandez | Tom Gorzelanny | Matt Capps | 90 | 105 | -15 |
| 2010-04-28 | @ CHN | 22 | W 3-2 | 15-7 | 1 | 36,660 | Luis Atilano | Ryan Dempster | Luis Atilano | Ryan Dempster | Matt Capps | 93 | 107 | -14 |
| 2010-04-30 | @ FLO | 23 | W 7-1 | 16-7 | 1 | 20,856 | Scott Olsen | Ricky Nolasco | Scott Olsen | Ricky Nolasco | | 100 | 108 | -8 |
| 2010-05-01 | @ FLO | 24 | L 1-7 | 16-8 | 1 | 34,886 | Craig Stammen | Chris Volstad | Chris Volstad | Craig Stammen | | 101 | 115 | -14 |
| 2010-05-02 | @ FLO | 25 | L 3-9 | 16-9 | 1 | 13,169 | John Lannan | Josh Johnson | Josh Johnson | John Lannan | | 104 | 124 | -20 |
| 2010-05-04 | vs ATL | 26 | W 6-3 | 17-9 | 1 | 17,098 | Livan Hernandez | Kenshin Kawakami | Livan Hernandez | Kenshin Kawakami | Matt Capps | 110 | 127 | -17 |
| 2010-05-05 | vs ATL | 27 | L 6-7 | 17-10 | 1 | 15,616 | Luis Atilano | Tommy Hanson | Kris Medlen | Matt Capps | Billy Wagner | 116 | 134 | -18 |
| 2010-05-06 | vs ATL | 28 | W 3-2 | 18-10 | 1 | 17,131 | Scott Olsen | Tim Hudson | Tyler Clippard | Eric O'Flaherty | | 119 | 136 | -17 |
| 2010-05-07 | vs FLO | 29 | L 2-4 | 18-11 | 1 | 20,161 | Craig Stammen | Chris Volstad | Chris Volstad | Brian Bruney | Leo Nunez | 121 | 140 | -19 |
| 2010-05-08 | vs FLO | 30 | W 5-4 | 19-11 | 1 | 21,633 | Matt Chico | Josh Johnson | Tyler Clippard | Burke Badenhop | Matt Capps | 126 | 144 | -18 |
| 2010-05-09 | vs FLO | 31 | W 3-2 | 20-11 | 1 | 21,299 | Livan Hernandez | Anibal Sanchez | Tyler Clippard | Clay Hensley | Matt Capps | 129 | 146 | -17 |
| 2010-05-10 | @ NYN | 32 | W 3-2 | 21-11 | 1 | 29,313 | Luis Atilano | John Maine | Luis Atilano | John Maine | Miguel Batista | 132 | 148 | -16 |
| 2010-05-11 | @ NYN | 33 | L 6-8 | 21-12 | 1 | 31,606 | Scott Olsen | Jonathon Niese | Raul Valdes | Tyler Clippard | Francisco Rodriguez | 138 | 156 | -18 |
| 2010-05-12 | @ NYN | 34 | W 6-4 | 22-12 | 1 | 33,024 | Craig Stammen | Mike Pelfrey | Tyler Clippard | Francisco Rodriguez | Matt Capps | 144 | 160 | -16 |
| 2010-05-13 | @ COL | 35 | W 14-6 | 22-13 | 1 | 20,795 | John Lannan | Jhoulis Chacin | Doug Slaten | Jhoulis Chacin | | 158 | 166 | -8 |
| 2010-05-15 | @ COL | 36 | L 2-6 | 22-15 | 2 | 29,111 | Livan Hernandez | Ubaldo Jimenez | Ubaldo Jimenez | Livan Hernandez | | 160 | 172 | -12 |
| 2010-05-15 | @ COL | 37 | L 3-4 | 22-15 | 2 | 35,258 | Luis Atilano | Jason Hammel | Jason Hammel | Sean Burnett | Manuel Corpas | 163 | 176 | -13 |
| 2010-05-16 | @ COL | 38 | L 1-2 | 22-16 | 1 | 42,874 | Scott Olsen | Jeff Francis | Matt Belisle | Tyler Clippard | Manuel Corpas | 164 | 178 | -14 |
| 2010-05-17 | @ SLN | 39 | L 2-6 | 22-17 | 1 | 38,005 | Craig Stammen | Kyle Lohse | Kyle Lohse | Craig Stammen | | 166 | 184 | -18 |
| 2010-05-18 | @ SLN | 40 | L 2-3 | 22-18 | 1 | 36,345 | John Lannan | Chris Carpenter | Chris Carpenter | Tyler Clippard | Ryan Franklin | 168 | 187 | -19 |
| 2010-05-19 | vs NYN | 41 | W 5-3 | 23-18 | 1 | 19,384 | Livan Hernandez | R.A. Dickey | Drew Storen | Raul Valdes | Matt Capps | 173 | 190 | -17 |
| 2010-05-20 | vs NYN | 42 | L 7-10 | 24-18 | 1 | 23,612 | Luis Atilano | John Maine | Raul Valdes | Luis Atilano | | 180 | 200 | -20 |
| 2010-05-21 | vs BAL | 43 | L 3-5 | 24-19 | 1 | 27,378 | Scott Olsen | David Hernandez | David Hernandez | Scott Olsen | Alfredo Simon | 183 | 205 | -22 |
| 2010-05-22 | vs BAL | 44 | W 7-6 | 25-19 | 1 | 30,290 | Craig Stammen | Brad Bergesen | Tyler Walker | Mark Hendrickson | Matt Capps | 190 | 211 | -21 |
| 2010-05-23 | vs BAL | 45 | W 4-3 | 26-19 | 1 | 27,535 | John Lannan | Kevin Millwood | Doug Slaten | Cla Meredith | | 194 | 214 | -20 |
| 2010-05-25 | @ SFN | 46 | L 2-4 | 26-20 | 1 | 27,981 | Livan Hernandez | Todd Wellemeyer | Todd Wellemeyer | Livan Hernandez | Brian Wilson | 196 | 218 | -22 |
| 2010-05-26 | @ SFN | 47 | W 7-3 | 27-20 | 1 | 30,230 | Luis Atilano | Tim Lincecum | Luis Atilano | Tim Lincecum | | 203 | 221 | -18 |
| 2010-05-27 | @ SFN | 48 | L 4-5 | 27-21 | 1 | 28,251 | Craig Stammen | Barry Zito | Santiago Casilla | Sean Burnett | Brian Wilson | 207 | 226 | -19 |
| 2010-05-28 | @ SDN | 49 | W 5-3 | 28-21 | 1 | 23,468 | John Lannan | Clayton Richard | John Lannan | Clayton Richard | Matt Capps | 212 | 229 | -17 |
| 2010-05-29 | @ SDN | 50 | L 2-4 | 28-22 | 1 | 25,956 | J.D. Martin | Mat Latos | Mat Latos | J.D. Martin | Heath Bell | 214 | 233 | -19 |
| 2010-05-30 | @ SDN | 51 | L 2-3 | 28-23 | 1 | 28,591 | Livan Hernandez | Jon Garland | Luke Gregerson | Sean Burnett | | 216 | 236 | -20 |
| 2010-05-31 | @ HOU | 52 | W 14-4 | 28-24 | 2 | 34,704 | Luis Atilano | Roy Oswalt | Luis Atilano | Roy Oswalt | | 230 | 240 | -10 |
| 2010-06-01 | @ HOU | 53 | L 7-8 | 28-25 | 3 | 25,249 | Craig Stammen | Brett Myers | Wilton Lopez | Matt Capps | | 237 | 248 | -11 |
| 2010-06-02 | @ HOU | 54 | L 1-5 | 28-26 | 3 | 26,736 | John Lannan | Wandy Rodriguez | Wandy Rodriguez | John Lannan | | 238 | 253 | -15 |
| 2010-06-03 | @ HOU | 55 | L 4-6 | 28-27 | 3 | 21,814 | J.D. Martin | Brian Moehler | Matt Lindstrom | Matt Capps | | 242 | 259 | -17 |
| 2010-06-04 | vs CIN | 56 | W 4-2 | 29-27 | 3 | 33,774 | Livan Hernandez | Aaron Harang | Tyler Clippard | Enerio Del Rosario | Matt Capps | 246 | 261 | -15 |
| 2010-06-05 | vs CIN | 57 | L 1-5 | 29-28 | 3 | 22,896 | Luis Atilano | Mike Leake | Mike Leake | Luis Atilano | | 247 | 266 | -19 |
| 2010-06-06 | vs CIN | 58 | L 4-5 | 29-29 | 3 | 27,202 | Craig Stammen | Bronson Arroyo | Francisco Cordero | Doug Slaten | Nick Masset | 251 | 271 | -20 |
| 2010-06-08 | vs PIT | 59 | W 5-2 | 30-29 | 3 | 40,315 | Stephen Strasburg | Jeff Karstens | Stephen Strasburg | Jeff Karstens | Matt Capps | 256 | 273 | -17 |
| 2010-06-09 | vs PIT | 60 | W 7-5 | 31-29 | 3 | 18,876 | John Lannan | Brad Lincoln | Drew Storen | D.J. Carrasco | Matt Capps | 263 | 278 | -15 |
| 2010-06-10 | vs PIT | 61 | W 4-2 | 32-29 | 4 | 21,767 | Livan Hernandez | Zach Duke | Livan Hernandez | Zach Duke | Tyler Clippard | 267 | 280 | -13 |
| 2010-06-11 | @ CLE | 62 | L 2-7 | 32-30 | 3 | 22,041 | Luis Atilano | Jake Westbrook | Jake Westbrook | Luis Atilano | Chris Perez | 269 | 287 | -18 |
| 2010-06-12 | @ CLE | 63 | L 1-7 | 32-31 | 3 | 19,484 | J.D. Martin | Fausto Carmona | Fausto Carmona | J.D. Martin | | 270 | 294 | -24 |
| 2010-06-13 | @ CLE | 64 | W 9-4 | 33-31 | 3 | 32,876 | Stephen Strasburg | David Huff | Stephen Strasburg | David Huff | | 279 | 298 | -19 |
| 2010-06-15 | @ DET | 65 | L 4-7 | 33-32 | 3 | 24,821 | John Lannan | Max Scherzer | Max Scherzer | John Lannan | Jose Valverde | 283 | 305 | -22 |
| 2010-06-16 | @ DET | 66 | L 3-8 | 33-33 | 3 | 24,767 | Livan Hernandez | Justin Verlander | Justin Verlander | Livan Hernandez | | 286 | 313 | -27 |
| 2010-06-17 | @ DET | 67 | L 3-8 | 33-34 | 3 | 33,630 | Luis Atilano | Jeremy Bonderman | Jeremy Bonderman | Luis Atilano | | 289 | 321 | -32 |
| 2010-06-18 | vs CHA | 68 | L 1-2 | 33-35 | 4 | 40,325 | Stephen Strasburg | Gavin Floyd | J.J. Putz | Drew Storen | Bobby Jenks | 290 | 323 | -33 |
| 2010-06-19 | vs CHA | 69 | L 0-1 | 33-36 | 4 | 36,487 | J.D. Martin | Jake Peavy | Jake Peavy | J.D. Martin | | 290 | 324 | -34 |
| 2010-06-20 | vs CHA | 70 | L 3-6 | 33-37 | 4 | 31,763 | John Lannan | Freddy Garcia | Freddy Garcia | John Lannan | J.J. Putz | 293 | 330 | -37 |
| 2010-06-21 | vs KCA | 71 | W 2-1 | 34-37 | 3 | 13,592 | Livan Hernandez | Bruce Chen | Livan Hernandez | Bruce Chen | Matt Capps | 295 | 331 | -36 |
| 2010-06-22 | vs KCA | 72 | W 4-3 | 35-37 | 3 | 21,168 | Luis Atilano | Anthony Lerew | Luis Atilano | Anthony Lerew | Matt Capps | 299 | 334 | -35 |
| 2010-06-23 | vs KCA | 73 | L 0-1 | 35-38 | 4 | 31,913 | Stephen Strasburg | Brian Bannister | Brian Bannister | Stephen Strasburg | Joakim Soria | 299 | 335 | -36 |
| 2010-06-25 | @ BAL | 74 | L 6-7 | 35-39 | 4 | 43,484 | J.D. Martin | Jake Arrieta | Alfredo Simon | Tyler Clippard | | 305 | 342 | -37 |
| 2010-06-26 | @ BAL | 75 | L 5-6 | 35-40 | 4 | 28,635 | Livan Hernandez | Brad Bergesen | Jason Berken | Sean Burnett | Alfredo Simon | 310 | 348 | -38 |
| 2010-06-27 | @ BAL | 76 | L 3-4 | 35-41 | 4 | 22,951 | Luis Atilano | Jeremy Guthrie | David Hernandez | Tyler Clippard | Alfredo Simon | 313 | 352 | -39 |
| 2010-06-28 | @ ATL | 77 | L 0-5 | 35-42 | 4 | 42,889 | Stephen Strasburg | Tim Hudson | Tim Hudson | Stephen Strasburg | | 313 | 357 | -44 |
| 2010-06-29 | @ ATL | 78 | W 7-2 | 36-42 | 4 | 19,045 | Craig Stammen | Derek Lowe | Craig Stammen | Derek Lowe | | 320 | 359 | -39 |
| 2010-06-30 | @ ATL | 79 | L 1-4 | 36-43 | 4 | 20,091 | J.D. Martin | Jair Jurrjens | Jair Jurrjens | J.D. Martin | Billy Wagner | 321 | 363 | -42 |
| 2010-07-01 | vs NYN | 80 | W 2-1 | 37-43 | 4 | 20,167 | Livan Hernandez | Johan Santana | Matt Capps | Pedro Feliciano | | 323 | 364 | -41 |
| 2010-07-02 | vs NYN | 81 | L 3-5 | 37-44 | 4 | 24,410 | Luis Atilano | Jonathon Niese | Jonathon Niese | Luis Atilano | Francisco Rodriguez | 326 | 369 | -43 |
| 2010-07-03 | vs NYN | 82 | W 6-5 | 38-44 | 3 | 39,214 | Stephen Strasburg | R.A. Dickey | Matt Capps | Francisco Rodriguez | | 332 | 374 | -42 |
| 2010-07-04 | vs NYN | 83 | L 5-9 | 38-45 | 3 | 29,234 | Craig Stammen | Hisanori Takahashi | Hisanori Takahashi | Craig Stammen | Francisco Rodriguez | 337 | 383 | -46 |
| 2010-07-06 | vs SDN | 84 | W 6-5 | 39-45 | 3 | 14,039 | Livan Hernandez | Clayton Richard | Matt Capps | Luke Gregerson | | 343 | 388 | -45 |
| 2010-07-07 | vs SDN | 85 | W 7-6 | 40-45 | 3 | 13,762 | J.D. Martin | Jon Garland | J.D. Martin | Jon Garland | Matt Capps | 350 | 394 | -44 |
| 2010-07-08 | vs SDN | 86 | L 1-7 | 40-46 | 3 | 17,364 | Luis Atilano | Mat Latos | Mat Latos | Luis Atilano | | 351 | 401 | -50 |
| 2010-07-09 | vs SFN | 87 | W 8-1 | 41-46 | 3 | 34,723 | Stephen Strasburg | Matt Cain | Stephen Strasburg | Matt Cain | | 359 | 402 | -43 |
| 2010-07-10 | vs SFN | 88 | L 5-10 | 42-46 | 3 | 23,977 | Craig Stammen | Jonathan Sanchez | Santiago Casilla | Tyler Clippard | | 364 | 412 | -48 |
| 2010-07-11 | vs SFN | 89 | L 2-6 | 42-47 | 3 | 22,403 | Livan Hernandez | Madison Bumgarner | Madison Bumgarner | Livan Hernandez | Brian Wilson | 366 | 418 | -52 |
| 2010-07-16 | @ FLO | 90 | W 4-0 | 43-47 | 3 | 27,037 | Stephen Strasburg | Ricky Nolasco | Stephen Strasburg | Ricky Nolasco | | 370 | 418 | -48 |
| 2010-07-17 | @ FLO | 91 | L 0-2 | 43-48 | 4 | 23,005 | Livan Hernandez | Josh Johnson | Josh Johnson | Livan Hernandez | Leo Nunez | 370 | 420 | -50 |
| 2010-07-18 | @ FLO | 92 | L 0-1 | 43-49 | 4 | 21,057 | Craig Stammen | Alejandro Sanabia | Alejandro Sanabia | Craig Stammen | Leo Nunez | 370 | 421 | -51 |
| 2010-07-19 | @ CIN | 93 | L 2-7 | 43-50 | 5 | 21,243 | J.D. Martin | Johnny Cueto | Johnny Cueto | J.D. Martin | | 372 | 428 | -56 |
| 2010-07-20 | @ CIN | 94 | L 7-8 | 43-51 | 5 | 22,876 | Luis Atilano | Mike Leake | Mike Leake | Luis Atilano | Francisco Cordero | 379 | 436 | -57 |
| 2010-07-21 | @ CIN | 95 | W 8-5 | 44-51 | 5 | 37,868 | Stephen Strasburg | Bronson Arroyo | Stephen Strasburg | Bronson Arroyo | Matt Capps | 387 | 441 | -54 |
| 2010-07-22 | @ CIN | 96 | W 7-1 | 45-51 | 5 | 23,115 | Livan Hernandez | Edinson Volquez | Livan Hernandez | Edinson Volquez | | 394 | 442 | -48 |
| 2010-07-23 | @ MIL | 97 | L 5-7 | 45-52 | 5 | 34,822 | Craig Stammen | Chris Narveson | Kameron Loe | Sean Burnett | John Axford | 399 | 449 | -50 |
| 2010-07-24 | @ MIL | 98 | L 3-4 | 45-53 | 5 | 41,987 | J.D. Martin | Manny Parra | John Axford | Drew Storen | | 402 | 453 | -51 |
| 2010-07-25 | @ MIL | 99 | L 3-8 | 45-54 | 5 | 42,414 | Ross Detwiler | David Bush | David Bush | Ross Detwiler | | 405 | 461 | -56 |
| 2010-07-27 | vs ATL | 100 | W 3-0 | 46-54 | 5 | 40,043 | Miguel Batista | Tommy Hanson | Miguel Batista | Tommy Hanson | Matt Capps | 408 | 461 | -53 |
| 2010-07-28 | vs ATL | 101 | L 1-3 | 46-55 | 5 | 24,263 | Livan Hernandez | Tim Hudson | Tim Hudson | Livan Hernandez | Billy Wagner | 409 | 464 | -55 |
| 2010-07-29 | vs ATL | 102 | W 5-3 | 47-55 | 5 | 30,263 | Scott Olsen | Derek Lowe | Scott Olsen | Derek Lowe | Matt Capps | 414 | 467 | -53 |
| 2010-07-30 | vs PHI | 103 | W 8-1 | 48-55 | 5 | 32,590 | Craig Stammen | Roy Oswalt | Craig Stammen | Roy Oswalt | | 422 | 468 | -46 |
| 2010-07-31 | vs PHI | 104 | W 7-5 | 49-55 | 5 | 38,049 | Ross Detwiler | Joe Blanton | Drew Storen | Brad Lidge | | 429 | 473 | -44 |
| 2010-08-01 | vs PHI | 105 | L 4-6 | 49-56 | 5 | 35,807 | John Lannan | Cole Hamels | Jose Contreras | Collin Balester | Brad Lidge | 433 | 479 | -46 |
| 2010-08-02 | @ ARI | 106 | W 3-1 | 50-56 | 5 | 16,793 | Livan Hernandez | Rodrigo Lopez | Livan Hernandez | Rodrigo Lopez | Sean Burnett | 436 | 480 | -44 |
| 2010-08-03 | @ ARI | 107 | L 1-6 | 50-57 | 5 | 17,164 | Scott Olsen | Joe Saunders | Joe Saunders | Scott Olsen | | 437 | 486 | -49 |
| 2010-08-04 | @ ARI | 108 | W 7-2 | 51-57 | 5 | 15,670 | Craig Stammen | Ian Kennedy | Craig Stammen | Ian Kennedy | | 444 | 488 | -44 |
| 2010-08-05 | @ ARI | 109 | L 4-8 | 51-58 | 5 | 16,638 | Ross Detwiler | Barry Enright | Barry Enright | Ross Detwiler | | 448 | 496 | -48 |
| 2010-08-06 | @ LAN | 110 | W 6-3 | 52-58 | 5 | 39,153 | John Lannan | Clayton Kershaw | John Lannan | Clayton Kershaw | Drew Storen | 454 | 499 | -45 |
| 2010-08-07 | @ LAN | 111 | L 2-3 | 52-59 | 5 | 44,896 | Livan Hernandez | Hiroki Kuroda | Jonathan Broxton | Sean Burnett | | 456 | 502 | -46 |
| 2010-08-08 | @ LAN | 112 | L 3-8 | 52-60 | 5 | 43,639 | Jason Marquis | Ted Lilly | Ted Lilly | Jason Marquis | | 459 | 510 | -51 |
| 2010-08-10 | vs FLO | 113 | L 2-8 | 52-61 | 5 | 25,939 | Stephen Strasburg | Anibal Sanchez | Anibal Sanchez | Stephen Strasburg | | 461 | 518 | -57 |
| 2010-08-11 | vs FLO | 114 | L 5-9 | 52-62 | 5 | 15,061 | Scott Olsen | Chris Volstad | Chris Volstad | Scott Olsen | | 466 | 527 | -61 |
| 2010-08-12 | vs FLO | 115 | L 0-5 | 52-63 | 5 | 16,496 | Livan Hernandez | Ricky Nolasco | Ricky Nolasco | Livan Hernandez | | 466 | 532 | -66 |
| 2010-08-13 | vs ARI | 116 | W 4-2 | 53-63 | 5 | 19,549 | John Lannan | Joe Saunders | John Lannan | Joe Saunders | Sean Burnett | 470 | 534 | -64 |
| 2010-08-14 | vs ARI | 117 | L 2-9 | 53-64 | 5 | 22,400 | Jason Marquis | Ian Kennedy | Ian Kennedy | Jason Marquis | | 472 | 543 | -71 |
| 2010-08-15 | vs ARI | 118 | W 5-3 | 54-64 | 5 | 21,695 | Stephen Strasburg | Barry Enright | Tyler Clippard | Jordan Norberto | Drew Storen | 477 | 546 | -69 |
| 2010-08-17 | @ ATL | 119 | L 2-10 | 55-64 | 5 | 16,911 | Scott Olsen | Mike Minor | Mike Minor | Scott Olsen | | 479 | 556 | -77 |
| 2010-08-18 | @ ATL | 120 | L 2-3 | 55-65 | 5 | 18,105 | Livan Hernandez | Tim Hudson | Billy Wagner | Sean Burnett | | 481 | 559 | -78 |
| 2010-08-19 | @ ATL | 121 | W 6-2 | 56-65 | 5 | 15,593 | John Lannan | Derek Lowe | John Lannan | Derek Lowe | | 487 | 561 | -74 |
| 2010-08-20 | @ PHI | 122 | L 0-1 | 56-66 | 5 | 45,093 | Jason Marquis | Roy Halladay | Roy Halladay | Jason Marquis | Brad Lidge | 487 | 562 | -75 |
| 2010-08-21 | @ PHI | 123 | W 8-1 | 57-66 | 5 | 45,266 | Stephen Strasburg | Kyle Kendrick | Doug Slaten | Kyle Kendrick | | 495 | 563 | -68 |
| 2010-08-22 | @ PHI | 124 | L 0-6 | 57-67 | 5 | 44,539 | Scott Olsen | Roy Oswalt | Roy Oswalt | Scott Olsen | | 495 | 569 | -74 |
| 2010-08-23 | vs CHN | 125 | L 1-9 | 57-68 | 5 | 17,921 | Livan Hernandez | Casey Coleman | Casey Coleman | Livan Hernandez | | 496 | 578 | -82 |
| 2010-08-24 | vs CHN | 126 | L 4-5 | 57-69 | 5 | 18,250 | John Lannan | Carlos Zambrano | Carlos Zambrano | John Lannan | Carlos Marmol | 500 | 583 | -83 |
| 2010-08-25 | vs CHN | 127 | L 0-4 | 57-70 | 5 | 18,344 | Jason Marquis | Ryan Dempster | Ryan Dempster | Jason Marquis | | 500 | 587 | -87 |
| 2010-08-26 | vs SLN | 128 | W 11-10 | 58-70 | 5 | 22,317 | Jordan Zimmermann | Chris Carpenter | Doug Slaten | Blake Hawksworth | | 511 | 597 | -86 |
| 2010-08-27 | vs SLN | 129 | L 2-4 | 58-71 | 5 | 22,871 | Scott Olsen | Jaime Garcia | Jaime Garcia | Scott Olsen | Ryan Franklin | 513 | 601 | -88 |
| 2010-08-28 | vs SLN | 130 | W 14-5 | 58-72 | 5 | 30,688 | Livan Hernandez | Kyle Lohse | Livan Hernandez | Kyle Lohse | | 527 | 606 | -79 |
| 2010-08-29 | vs SLN | 131 | W 4-2 | 59-72 | 5 | 24,782 | John Lannan | Adam Wainwright | John Lannan | Adam Wainwright | Drew Storen | 531 | 608 | -77 |
| 2010-08-30 | @ FLO | 132 | W 9-3 | 60-72 | 5 | 18,326 | Jason Marquis | Alejandro Sanabia | Jason Marquis | Alejandro Sanabia | | 540 | 611 | -71 |
| 2010-08-31 | @ FLO | 133 | L 0-1 | 60-73 | 5 | 18,506 | Jordan Zimmermann | Anibal Sanchez | Clay Hensley | Drew Storen | | 540 | 612 | -72 |
| 2010-09-01 | @ FLO | 134 | L 10-16 | 60-74 | 5 | 18,045 | Scott Olsen | Chris Volstad | Chris Volstad | Scott Olsen | | 550 | 628 | -78 |
| 2010-09-03 | @ PIT | 135 | L 5-8 | 60-75 | 5 | 19,734 | Livan Hernandez | Zach Duke | Zach Duke | Livan Hernandez | Joel Hanrahan | 555 | 636 | -81 |
| 2010-09-04 | @ PIT | 136 | W 9-2 | 61-75 | 5 | 30,263 | John Lannan | Paul Maholm | John Lannan | Paul Maholm | | 564 | 638 | -74 |
| 2010-09-05 | @ PIT | 137 | W 8-1 | 62-75 | 5 | 18,057 | Jason Marquis | Charlie Morton | Jason Marquis | Charlie Morton | | 572 | 639 | -67 |
| 2010-09-06 | vs NYN | 138 | W 13-3 | 62-76 | 7 | 20,224 | Jordan Zimmermann | Mike Pelfrey | Scott Olsen | Mike Pelfrey | | 585 | 642 | -57 |
| 2010-09-07 | vs NYN | 139 | L 1-4 | 62-77 | 5 | 13,835 | Yuniesky Maya | Dillon Gee | Dillon Gee | Yuniesky Maya | Hisanori Takahashi | 586 | 646 | -60 |
| 2010-09-08 | vs NYN | 140 | L 2-3 | 62-78 | 5 | 16,002 | Livan Hernandez | R.A. Dickey | R.A. Dickey | Livan Hernandez | Hisanori Takahashi | 588 | 649 | -61 |
| 2010-09-10 | vs FLO | 141 | L 1-3 | 62-79 | 5 | 17,180 | John Lannan | Alejandro Sanabia | Alejandro Sanabia | John Lannan | Clay Hensley | 589 | 652 | -63 |
| 2010-09-11 | vs FLO | 142 | L 1-4 | 62-80 | 5 | 17,941 | Jason Marquis | Anibal Sanchez | Anibal Sanchez | Jason Marquis | Clay Hensley | 590 | 656 | -66 |
| 2010-09-12 | vs FLO | 143 | L 5-6 | 62-81 | 5 | 16,788 | Jordan Zimmermann | Chris Volstad | Brian Sanches | Jordan Zimmermann | Clay Hensley | 595 | 662 | -67 |
| 2010-09-13 | @ ATL | 144 | L 0-4 | 62-82 | 5 | 18,647 | Yuniesky Maya | Derek Lowe | Derek Lowe | Yuniesky Maya | | 595 | 666 | -71 |
| 2010-09-14 | @ ATL | 145 | W 6-0 | 63-82 | 5 | 26,954 | Livan Hernandez | Jair Jurrjens | Livan Hernandez | Jair Jurrjens | | 601 | 666 | -65 |
| 2010-09-15 | @ ATL | 146 | W 4-2 | 64-82 | 5 | 19,237 | John Lannan | Mike Minor | John Lannan | Mike Minor | Drew Storen | 605 | 668 | -63 |
| 2010-09-17 | @ PHI | 147 | L 1-9 | 64-83 | 5 | 45,338 | Jason Marquis | Roy Oswalt | Roy Oswalt | Jason Marquis | | 606 | 677 | -71 |
| 2010-09-18 | @ PHI | 148 | L 2-5 | 64-84 | 5 | 45,222 | Jordan Zimmermann | Kyle Kendrick | Kyle Kendrick | Jordan Zimmermann | Brad Lidge | 608 | 682 | -74 |
| 2010-09-19 | @ PHI | 149 | L 6-7 | 64-85 | 5 | 44,936 | Yuniesky Maya | Joe Blanton | Vance Worley | Drew Storen | | 614 | 689 | -75 |
| 2010-09-20 | vs HOU | 150 | L 2-8 | 64-86 | 5 | 10,999 | Livan Hernandez | Bud Norris | Bud Norris | Livan Hernandez | | 616 | 697 | -81 |
| 2010-09-21 | vs HOU | 151 | W 8-4 | 65-86 | 5 | 11,893 | John Lannan | J.A. Happ | Tyler Clippard | Felipe Paulino | | 624 | 701 | -77 |
| 2010-09-22 | vs HOU | 152 | W 4-3 | 66-86 | 5 | 12,213 | Jason Marquis | Wandy Rodriguez | Tyler Clippard | Jeff Fulchino | Sean Burnett | 628 | 704 | -76 |
| 2010-09-23 | vs HOU | 153 | W 7-2 | 67-86 | 5 | 14,633 | Ross Detwiler | Nelson Figueroa | Ross Detwiler | Nelson Figueroa | | 635 | 706 | -71 |
| 2010-09-24 | vs ATL | 154 | W 8-3 | 68-86 | 5 | 22,515 | Jordan Zimmermann | Tim Hudson | Jordan Zimmermann | Tim Hudson | | 643 | 709 | -66 |
| 2010-09-25 | vs ATL | 155 | L 0-5 | 68-87 | 5 | 23,824 | Yuniesky Maya | Derek Lowe | Derek Lowe | Yuniesky Maya | | 643 | 714 | -71 |
| 2010-09-26 | vs ATL | 156 | W 4-2 | 69-87 | 5 | 21,625 | Livan Hernandez | Brandon Beachy | Sean Burnett | Kyle Farnsworth | Drew Storen | 647 | 716 | -69 |
| 2010-09-27 | vs PHI | 157 | L 0-8 | 69-88 | 5 | 14,309 | John Lannan | Roy Halladay | Roy Halladay | John Lannan | | 647 | 724 | -77 |
| 2010-09-28 | vs PHI | 158 | W 2-1 | 70-88 | 5 | 19,117 | Jason Marquis | Roy Oswalt | Drew Storen | Jose Contreras | | 649 | 725 | -76 |
| 2010-09-29 | vs PHI | 159 | L 1-7 | 70-89 | 6 | 20,026 | Ross Detwiler | Joe Blanton | Joe Blanton | Ross Detwiler | | 650 | 732 | -82 |
| 2010-10-01 | @ NYN | 160 | L 1-2 | 70-90 | 5 | 29,424 | Jordan Zimmermann | Pat Misch | Hisanori Takahashi | Tyler Clippard | | 651 | 734 | -83 |
| 2010-10-02 | @ NYN | 161 | L 2-7 | 70-91 | 5 | 30,386 | Yuniesky Maya | Raul Valdes | Ryota Igarashi | Tyler Clippard | | 653 | 741 | -88 |
| 2010-10-03 | @ NYN | 162 | W 2-1 | 71-91 | 5 | 30,849 | Livan Hernandez | Mike Pelfrey | Joel Peralta | Oliver Perez | Miguel Batista | 655 | 742 | -87 |